FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0688, 401 aa 1>>>pF1KE0688 401 - 401 aa - 401 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.2387+/-0.000346; mu= 5.0953+/- 0.022 mean_var=200.5886+/-42.141, 0's: 0 Z-trim(120.9): 26 B-trim: 667 in 2/56 Lambda= 0.090557 statistics sampled from 36844 (36870) to 36844 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.762), E-opt: 0.2 (0.432), width: 16 Scan time: 9.660 The best scores are: opt bits E(85289) NP_001139019 (OMIM: 606935) splicing factor 45 [Ho ( 401) 2645 357.8 2.7e-98 NP_116294 (OMIM: 606935) splicing factor 45 [Homo ( 401) 2645 357.8 2.7e-98 XP_016868729 (OMIM: 604819,615583) PREDICTED: poly ( 499) 236 43.1 0.0018 NP_001258029 (OMIM: 604819,615583) poly(U)-binding ( 499) 236 43.1 0.0018 NP_001258026 (OMIM: 604819,615583) poly(U)-binding ( 513) 236 43.1 0.0018 NP_001129505 (OMIM: 604819,615583) poly(U)-binding ( 516) 236 43.1 0.0018 XP_016868728 (OMIM: 604819,615583) PREDICTED: poly ( 516) 236 43.1 0.0018 NP_001258028 (OMIM: 604819,615583) poly(U)-binding ( 530) 236 43.2 0.0019 NP_001258025 (OMIM: 604819,615583) poly(U)-binding ( 541) 236 43.2 0.0019 NP_055096 (OMIM: 604819,615583) poly(U)-binding-sp ( 542) 236 43.2 0.0019 NP_001258027 (OMIM: 604819,615583) poly(U)-binding ( 558) 236 43.2 0.0019 NP_510965 (OMIM: 604819,615583) poly(U)-binding-sp ( 559) 236 43.2 0.0019 XP_016868725 (OMIM: 604819,615583) PREDICTED: poly ( 579) 236 43.2 0.002 XP_011515232 (OMIM: 604819,615583) PREDICTED: poly ( 579) 236 43.2 0.002 XP_016868724 (OMIM: 604819,615583) PREDICTED: poly ( 584) 236 43.2 0.002 XP_016868723 (OMIM: 604819,615583) PREDICTED: poly ( 596) 236 43.2 0.002 XP_016868727 (OMIM: 604819,615583) PREDICTED: poly ( 596) 236 43.2 0.002 XP_016868726 (OMIM: 604819,615583) PREDICTED: poly ( 596) 236 43.2 0.002 XP_011515231 (OMIM: 604819,615583) PREDICTED: poly ( 596) 236 43.2 0.002 >>NP_001139019 (OMIM: 606935) splicing factor 45 [Homo s (401 aa) initn: 2645 init1: 2645 opt: 2645 Z-score: 1885.6 bits: 357.8 E(85289): 2.7e-98 Smith-Waterman score: 2645; 100.0% identity (100.0% similar) in 401 aa overlap (1-401:1-401) 10 20 30 40 50 60 pF1KE0 MSLYDDLGVETSDSKTEGWSKNFKLLQSQLQVKKAALTQAKSQRTKQSTVLAPVIDLKRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSLYDDLGVETSDSKTEGWSKNFKLLQSQLQVKKAALTQAKSQRTKQSTVLAPVIDLKRG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 GSSDDRQIVDTPPHVAAGLKDPVPSGFSAGEVLIPLADEYDPMFPNDYEKVVKRQREERQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSSDDRQIVDTPPHVAAGLKDPVPSGFSAGEVLIPLADEYDPMFPNDYEKVVKRQREERQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 RQRELERQKEIEEREKRRKDRHEASGFARRPDPDSDEDEDYERERRKRSMGGAAIAPPTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RQRELERQKEIEEREKRRKDRHEASGFARRPDPDSDEDEDYERERRKRSMGGAAIAPPTS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 LVEKDKELPRDFPYEEDSRPRSQSSKAAIPPPVYEEQDRPRSPTGPSNSFLANMGGTVAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVEKDKELPRDFPYEEDSRPRSQSSKAAIPPPVYEEQDRPRSPTGPSNSFLANMGGTVAH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 KIMQKYGFREGQGLGKHEQGLSTALSVEKTSKRGGKIIVGDATEKDASKKSDSNPLTEIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KIMQKYGFREGQGLGKHEQGLSTALSVEKTSKRGGKIIVGDATEKDASKKSDSNPLTEIL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 KCPTKVVLLRNMVGAGEVDEDLEVETKEECEKYGKVGKCVIFEIPGAPDDEAVRIFLEFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KCPTKVVLLRNMVGAGEVDEDLEVETKEECEKYGKVGKCVIFEIPGAPDDEAVRIFLEFE 310 320 330 340 350 360 370 380 390 400 pF1KE0 RVESAIKAVVDLNGRYFGGRVVKACFYNLDKFRVLDLAEQV ::::::::::::::::::::::::::::::::::::::::: NP_001 RVESAIKAVVDLNGRYFGGRVVKACFYNLDKFRVLDLAEQV 370 380 390 400 >>NP_116294 (OMIM: 606935) splicing factor 45 [Homo sapi (401 aa) initn: 2645 init1: 2645 opt: 2645 Z-score: 1885.6 bits: 357.8 E(85289): 2.7e-98 Smith-Waterman score: 2645; 100.0% identity (100.0% similar) in 401 aa overlap (1-401:1-401) 10 20 30 40 50 60 pF1KE0 MSLYDDLGVETSDSKTEGWSKNFKLLQSQLQVKKAALTQAKSQRTKQSTVLAPVIDLKRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 MSLYDDLGVETSDSKTEGWSKNFKLLQSQLQVKKAALTQAKSQRTKQSTVLAPVIDLKRG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 GSSDDRQIVDTPPHVAAGLKDPVPSGFSAGEVLIPLADEYDPMFPNDYEKVVKRQREERQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 GSSDDRQIVDTPPHVAAGLKDPVPSGFSAGEVLIPLADEYDPMFPNDYEKVVKRQREERQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 RQRELERQKEIEEREKRRKDRHEASGFARRPDPDSDEDEDYERERRKRSMGGAAIAPPTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 RQRELERQKEIEEREKRRKDRHEASGFARRPDPDSDEDEDYERERRKRSMGGAAIAPPTS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 LVEKDKELPRDFPYEEDSRPRSQSSKAAIPPPVYEEQDRPRSPTGPSNSFLANMGGTVAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 LVEKDKELPRDFPYEEDSRPRSQSSKAAIPPPVYEEQDRPRSPTGPSNSFLANMGGTVAH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 KIMQKYGFREGQGLGKHEQGLSTALSVEKTSKRGGKIIVGDATEKDASKKSDSNPLTEIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 KIMQKYGFREGQGLGKHEQGLSTALSVEKTSKRGGKIIVGDATEKDASKKSDSNPLTEIL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 KCPTKVVLLRNMVGAGEVDEDLEVETKEECEKYGKVGKCVIFEIPGAPDDEAVRIFLEFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 KCPTKVVLLRNMVGAGEVDEDLEVETKEECEKYGKVGKCVIFEIPGAPDDEAVRIFLEFE 310 320 330 340 350 360 370 380 390 400 pF1KE0 RVESAIKAVVDLNGRYFGGRVVKACFYNLDKFRVLDLAEQV ::::::::::::::::::::::::::::::::::::::::: NP_116 RVESAIKAVVDLNGRYFGGRVVKACFYNLDKFRVLDLAEQV 370 380 390 400 >>XP_016868729 (OMIM: 604819,615583) PREDICTED: poly(U)- (499 aa) initn: 239 init1: 124 opt: 236 Z-score: 183.4 bits: 43.1 E(85289): 0.0018 Smith-Waterman score: 236; 41.6% identity (65.3% similar) in 101 aa overlap (301-398:398-498) 280 290 300 310 320 330 pF1KE0 SKRGGKIIVGDATEKDASKKSDSNPLTEILKCPTKVVLLRNMVGAGEVDEDLEVETKEEC : . :..::::: ..:.::: :. ::: XP_016 SERPEMLSEQEHMSISGSSARHMVMQKLLRKQESTVMVLRNMVDPKDIDDDLEGEVTEEC 370 380 390 400 410 420 340 350 360 370 380 pF1KE0 EKYGKVGKCVIF-EIPGAPDDEA--VRIFLEFERVESAIKAVVDLNGRYFGGRVVKACFY :.: :.. .:. : : .: :.::.:: . . ::. ::::.:.:: : : : XP_016 GKFGAVNRVIIYQEKQGEEEDAEIIVKIFVEFSIASETHKAIQALNGRWFAGRKVVAEVY 430 440 450 460 470 480 390 400 pF1KE0 NLDKFRVLDLAEQV . ..: ::. XP_016 DQERFDNSDLSA 490 >>NP_001258029 (OMIM: 604819,615583) poly(U)-binding-spl (499 aa) initn: 239 init1: 124 opt: 236 Z-score: 183.4 bits: 43.1 E(85289): 0.0018 Smith-Waterman score: 236; 41.6% identity (65.3% similar) in 101 aa overlap (301-398:398-498) 280 290 300 310 320 330 pF1KE0 SKRGGKIIVGDATEKDASKKSDSNPLTEILKCPTKVVLLRNMVGAGEVDEDLEVETKEEC : . :..::::: ..:.::: :. ::: NP_001 SERPEMLSEQEHMSISGSSARHMVMQKLLRKQESTVMVLRNMVDPKDIDDDLEGEVTEEC 370 380 390 400 410 420 340 350 360 370 380 pF1KE0 EKYGKVGKCVIF-EIPGAPDDEA--VRIFLEFERVESAIKAVVDLNGRYFGGRVVKACFY :.: :.. .:. : : .: :.::.:: . . ::. ::::.:.:: : : : NP_001 GKFGAVNRVIIYQEKQGEEEDAEIIVKIFVEFSIASETHKAIQALNGRWFAGRKVVAEVY 430 440 450 460 470 480 390 400 pF1KE0 NLDKFRVLDLAEQV . ..: ::. NP_001 DQERFDNSDLSA 490 >>NP_001258026 (OMIM: 604819,615583) poly(U)-binding-spl (513 aa) initn: 239 init1: 124 opt: 236 Z-score: 183.3 bits: 43.1 E(85289): 0.0018 Smith-Waterman score: 236; 41.6% identity (65.3% similar) in 101 aa overlap (301-398:412-512) 280 290 300 310 320 330 pF1KE0 SKRGGKIIVGDATEKDASKKSDSNPLTEILKCPTKVVLLRNMVGAGEVDEDLEVETKEEC : . :..::::: ..:.::: :. ::: NP_001 SERPEMLSEQEHMSISGSSARHMVMQKLLRKQESTVMVLRNMVDPKDIDDDLEGEVTEEC 390 400 410 420 430 440 340 350 360 370 380 pF1KE0 EKYGKVGKCVIF-EIPGAPDDEA--VRIFLEFERVESAIKAVVDLNGRYFGGRVVKACFY :.: :.. .:. : : .: :.::.:: . . ::. ::::.:.:: : : : NP_001 GKFGAVNRVIIYQEKQGEEEDAEIIVKIFVEFSIASETHKAIQALNGRWFAGRKVVAEVY 450 460 470 480 490 500 390 400 pF1KE0 NLDKFRVLDLAEQV . ..: ::. NP_001 DQERFDNSDLSA 510 >>NP_001129505 (OMIM: 604819,615583) poly(U)-binding-spl (516 aa) initn: 239 init1: 124 opt: 236 Z-score: 183.2 bits: 43.1 E(85289): 0.0018 Smith-Waterman score: 236; 41.6% identity (65.3% similar) in 101 aa overlap (301-398:415-515) 280 290 300 310 320 330 pF1KE0 SKRGGKIIVGDATEKDASKKSDSNPLTEILKCPTKVVLLRNMVGAGEVDEDLEVETKEEC : . :..::::: ..:.::: :. ::: NP_001 SERPEMLSEQEHMSISGSSARHMVMQKLLRKQESTVMVLRNMVDPKDIDDDLEGEVTEEC 390 400 410 420 430 440 340 350 360 370 380 pF1KE0 EKYGKVGKCVIF-EIPGAPDDEA--VRIFLEFERVESAIKAVVDLNGRYFGGRVVKACFY :.: :.. .:. : : .: :.::.:: . . ::. ::::.:.:: : : : NP_001 GKFGAVNRVIIYQEKQGEEEDAEIIVKIFVEFSIASETHKAIQALNGRWFAGRKVVAEVY 450 460 470 480 490 500 390 400 pF1KE0 NLDKFRVLDLAEQV . ..: ::. NP_001 DQERFDNSDLSA 510 >>XP_016868728 (OMIM: 604819,615583) PREDICTED: poly(U)- (516 aa) initn: 239 init1: 124 opt: 236 Z-score: 183.2 bits: 43.1 E(85289): 0.0018 Smith-Waterman score: 236; 41.6% identity (65.3% similar) in 101 aa overlap (301-398:415-515) 280 290 300 310 320 330 pF1KE0 SKRGGKIIVGDATEKDASKKSDSNPLTEILKCPTKVVLLRNMVGAGEVDEDLEVETKEEC : . :..::::: ..:.::: :. ::: XP_016 SERPEMLSEQEHMSISGSSARHMVMQKLLRKQESTVMVLRNMVDPKDIDDDLEGEVTEEC 390 400 410 420 430 440 340 350 360 370 380 pF1KE0 EKYGKVGKCVIF-EIPGAPDDEA--VRIFLEFERVESAIKAVVDLNGRYFGGRVVKACFY :.: :.. .:. : : .: :.::.:: . . ::. ::::.:.:: : : : XP_016 GKFGAVNRVIIYQEKQGEEEDAEIIVKIFVEFSIASETHKAIQALNGRWFAGRKVVAEVY 450 460 470 480 490 500 390 400 pF1KE0 NLDKFRVLDLAEQV . ..: ::. XP_016 DQERFDNSDLSA 510 >>NP_001258028 (OMIM: 604819,615583) poly(U)-binding-spl (530 aa) initn: 239 init1: 124 opt: 236 Z-score: 183.1 bits: 43.2 E(85289): 0.0019 Smith-Waterman score: 236; 41.6% identity (65.3% similar) in 101 aa overlap (301-398:429-529) 280 290 300 310 320 330 pF1KE0 SKRGGKIIVGDATEKDASKKSDSNPLTEILKCPTKVVLLRNMVGAGEVDEDLEVETKEEC : . :..::::: ..:.::: :. ::: NP_001 SERPEMLSEQEHMSISGSSARHMVMQKLLRKQESTVMVLRNMVDPKDIDDDLEGEVTEEC 400 410 420 430 440 450 340 350 360 370 380 pF1KE0 EKYGKVGKCVIF-EIPGAPDDEA--VRIFLEFERVESAIKAVVDLNGRYFGGRVVKACFY :.: :.. .:. : : .: :.::.:: . . ::. ::::.:.:: : : : NP_001 GKFGAVNRVIIYQEKQGEEEDAEIIVKIFVEFSIASETHKAIQALNGRWFAGRKVVAEVY 460 470 480 490 500 510 390 400 pF1KE0 NLDKFRVLDLAEQV . ..: ::. NP_001 DQERFDNSDLSA 520 530 >>NP_001258025 (OMIM: 604819,615583) poly(U)-binding-spl (541 aa) initn: 239 init1: 124 opt: 236 Z-score: 183.0 bits: 43.2 E(85289): 0.0019 Smith-Waterman score: 236; 41.6% identity (65.3% similar) in 101 aa overlap (301-398:440-540) 280 290 300 310 320 330 pF1KE0 SKRGGKIIVGDATEKDASKKSDSNPLTEILKCPTKVVLLRNMVGAGEVDEDLEVETKEEC : . :..::::: ..:.::: :. ::: NP_001 SERPEMLSEQEHMSISGSSARHMVMQKLLRKQESTVMVLRNMVDPKDIDDDLEGEVTEEC 410 420 430 440 450 460 340 350 360 370 380 pF1KE0 EKYGKVGKCVIF-EIPGAPDDEA--VRIFLEFERVESAIKAVVDLNGRYFGGRVVKACFY :.: :.. .:. : : .: :.::.:: . . ::. ::::.:.:: : : : NP_001 GKFGAVNRVIIYQEKQGEEEDAEIIVKIFVEFSIASETHKAIQALNGRWFAGRKVVAEVY 470 480 490 500 510 520 390 400 pF1KE0 NLDKFRVLDLAEQV . ..: ::. NP_001 DQERFDNSDLSA 530 540 >>NP_055096 (OMIM: 604819,615583) poly(U)-binding-splici (542 aa) initn: 239 init1: 124 opt: 236 Z-score: 183.0 bits: 43.2 E(85289): 0.0019 Smith-Waterman score: 236; 41.6% identity (65.3% similar) in 101 aa overlap (301-398:441-541) 280 290 300 310 320 330 pF1KE0 SKRGGKIIVGDATEKDASKKSDSNPLTEILKCPTKVVLLRNMVGAGEVDEDLEVETKEEC : . :..::::: ..:.::: :. ::: NP_055 SERPEMLSEQEHMSISGSSARHMVMQKLLRKQESTVMVLRNMVDPKDIDDDLEGEVTEEC 420 430 440 450 460 470 340 350 360 370 380 pF1KE0 EKYGKVGKCVIF-EIPGAPDDEA--VRIFLEFERVESAIKAVVDLNGRYFGGRVVKACFY :.: :.. .:. : : .: :.::.:: . . ::. ::::.:.:: : : : NP_055 GKFGAVNRVIIYQEKQGEEEDAEIIVKIFVEFSIASETHKAIQALNGRWFAGRKVVAEVY 480 490 500 510 520 530 390 400 pF1KE0 NLDKFRVLDLAEQV . ..: ::. NP_055 DQERFDNSDLSA 540 401 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 02:46:42 2016 done: Sat Nov 5 02:46:44 2016 Total Scan time: 9.660 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]