Result of FASTA (omim) for
pF1KE0690
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0690, 401 aa
1>>>pF1KE0690 401 - 401 aa - 401 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 14.2699+/-0.000572; mu= -27.3621+/- 0.034
mean_var=791.0379+/-183.230, 0's: 0 Z-trim(117.0): 63 B-trim: 1785 in 1/52
Lambda= 0.045601
statistics sampled from 28604 (28663) to 28604 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.679), E-opt: 0.2 (0.336), width: 16
Scan time: 9.350
The best scores are: opt bits E(85289)
NP_543026 (OMIM: 609370) serine/threonine-protein ( 534) 2668 191.5 4e-48
XP_005245800 (OMIM: 610785) PREDICTED: serine/thre ( 341) 1532 116.6 9.4e-26
NP_001230461 (OMIM: 610785) serine/threonine-prote ( 341) 1532 116.6 9.4e-26
NP_690048 (OMIM: 610785) serine/threonine-protein ( 341) 1532 116.6 9.4e-26
NP_001230462 (OMIM: 610785) serine/threonine-prote ( 341) 1532 116.6 9.4e-26
XP_011539094 (OMIM: 610785) PREDICTED: serine/thre ( 257) 1112 88.8 1.6e-17
XP_006710444 (OMIM: 610785) PREDICTED: serine/thre ( 263) 1099 88.0 3e-17
XP_011527476 (OMIM: 609370) PREDICTED: serine/thre ( 430) 1088 87.5 6.8e-17
>>NP_543026 (OMIM: 609370) serine/threonine-protein kina (534 aa)
initn: 2668 init1: 2668 opt: 2668 Z-score: 985.0 bits: 191.5 E(85289): 4e-48
Smith-Waterman score: 2668; 100.0% identity (100.0% similar) in 401 aa overlap (1-401:134-534)
10 20 30
pF1KE0 METGKDGARRGTQSPERKRRSPVPRAPSTK
::::::::::::::::::::::::::::::
NP_543 PAPPRPRAGRRDEAGGARAAPLLLPPPPAAMETGKDGARRGTQSPERKRRSPVPRAPSTK
110 120 130 140 150 160
40 50 60 70 80 90
pF1KE0 LRPAAAARAMDPVAAEAPGEAFLARRRPEGGGGSARPRYSLLAEIGRGSYGVVYEAVAGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_543 LRPAAAARAMDPVAAEAPGEAFLARRRPEGGGGSARPRYSLLAEIGRGSYGVVYEAVAGR
170 180 190 200 210 220
100 110 120 130 140 150
pF1KE0 SGARVAVKKIRCDAPENVELALAEFWALTSLKRRHQNVVQFEECVLQRNGLAQRMSHGNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_543 SGARVAVKKIRCDAPENVELALAEFWALTSLKRRHQNVVQFEECVLQRNGLAQRMSHGNK
230 240 250 260 270 280
160 170 180 190 200 210
pF1KE0 SSQLYLRLVETSLKGERILGYAEEPCYLWFVMEFCEGGDLNQYVLSRRPDPATNKSFMLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_543 SSQLYLRLVETSLKGERILGYAEEPCYLWFVMEFCEGGDLNQYVLSRRPDPATNKSFMLQ
290 300 310 320 330 340
220 230 240 250 260 270
pF1KE0 LTSAIAFLHKNHIVHRDLKPDNILITERSGTPILKVADFGLSKVCAGLAPRGKEGNQDNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_543 LTSAIAFLHKNHIVHRDLKPDNILITERSGTPILKVADFGLSKVCAGLAPRGKEGNQDNK
350 360 370 380 390 400
280 290 300 310 320 330
pF1KE0 NVNVNKYWLSSACGSDFYMAPEVWEGHYTAKADIFALGIIIWAMIERITFIDSETKKELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_543 NVNVNKYWLSSACGSDFYMAPEVWEGHYTAKADIFALGIIIWAMIERITFIDSETKKELL
410 420 430 440 450 460
340 350 360 370 380 390
pF1KE0 GTYIKQGTEIVPVGEALLENPKMELHIPQKRRTSMSEGIKQLLKDMLAANPQDRPDAFEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_543 GTYIKQGTEIVPVGEALLENPKMELHIPQKRRTSMSEGIKQLLKDMLAANPQDRPDAFEL
470 480 490 500 510 520
400
pF1KE0 ETRMDQVTCAA
:::::::::::
NP_543 ETRMDQVTCAA
530
>>XP_005245800 (OMIM: 610785) PREDICTED: serine/threonin (341 aa)
initn: 1491 init1: 527 opt: 1532 Z-score: 583.3 bits: 116.6 E(85289): 9.4e-26
Smith-Waterman score: 1532; 69.3% identity (87.0% similar) in 339 aa overlap (64-397:3-332)
40 50 60 70 80 90
pF1KE0 AAAARAMDPVAAEAPGEAFLARRRPEGGGGSARPRYSLLAEIGRGSYGVVYEAVAGRSGA
:..:.:.:. :.:::::::::::: ...:
XP_005 MVSSQPKYDLIREVGRGSYGVVYEAVIRKTSA
10 20 30
100 110 120 130 140 150
pF1KE0 RVAVKKIRCDAPENVELALAEFWALTSLKRRHQNVVQFEECVLQRNGLAQRMSHGNKSSQ
::::::::: ::::::::: :::::.:.: .: ::...:::.::..:..:.::::..::
XP_005 RVAVKKIRCHAPENVELALREFWALSSIKSQHPNVIHLEECILQKDGMVQKMSHGSNSS-
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE0 LYLRLVETSLKGERILGYAEEPCYLWFVMEFCEGGDLNQYVLSRRPDPATNKSFMLQLTS
:::.::::::::: : . ::::::.::.:::.:.:.:::.:. :: ::::::.:
XP_005 LYLQLVETSLKGE-IAFDPRSAYYLWFVMDFCDGGDMNEYLLSRKPNRKTNTSFMLQLSS
100 110 120 130 140 150
220 230 240 250 260
pF1KE0 AIAFLHKNHIVHRDLKPDNILITE-RSGT----PILKVADFGLSKVCAGLAPRGKEGNQD
:.::::::.:.:::::::::::.. : : : ::::::::::::.. :..
XP_005 ALAFLHKNQIIHRDLKPDNILISQTRLDTSDLEPTLKVADFGLSKVCSA------SGQNP
160 170 180 190 200
270 280 290 300 310 320
pF1KE0 NKNVNVNKYWLSSACGSDFYMAPEVWEGHYTAKADIFALGIIIWAMIERITFIDSETKKE
.. :.::: .::.:::.:::::::::::::::::::::::::::::.:::::::.:::::
XP_005 EEPVSVNKCFLSTACGTDFYMAPEVWEGHYTAKADIFALGIIIWAMLERITFIDTETKKE
210 220 230 240 250 260
330 340 350 360 370 380
pF1KE0 LLGTYIKQGTEIVPVGEALLENPKMELHIPQKRRTSMSEGIKQLLKDMLAANPQDRPDAF
:::.:.::::::::::::::::::::: :: :.. ::. .:::.:.:::::::::::::
XP_005 LLGSYVKQGTEIVPVGEALLENPKMELLIPVKKK-SMNGRMKQLIKEMLAANPQDRPDAF
270 280 290 300 310 320
390 400
pF1KE0 ELETRMDQVTCAA
::: :. :.
XP_005 ELELRLVQIAFKDSSWET
330 340
>>NP_001230461 (OMIM: 610785) serine/threonine-protein k (341 aa)
initn: 1491 init1: 527 opt: 1532 Z-score: 583.3 bits: 116.6 E(85289): 9.4e-26
Smith-Waterman score: 1532; 69.3% identity (87.0% similar) in 339 aa overlap (64-397:3-332)
40 50 60 70 80 90
pF1KE0 AAAARAMDPVAAEAPGEAFLARRRPEGGGGSARPRYSLLAEIGRGSYGVVYEAVAGRSGA
:..:.:.:. :.:::::::::::: ...:
NP_001 MVSSQPKYDLIREVGRGSYGVVYEAVIRKTSA
10 20 30
100 110 120 130 140 150
pF1KE0 RVAVKKIRCDAPENVELALAEFWALTSLKRRHQNVVQFEECVLQRNGLAQRMSHGNKSSQ
::::::::: ::::::::: :::::.:.: .: ::...:::.::..:..:.::::..::
NP_001 RVAVKKIRCHAPENVELALREFWALSSIKSQHPNVIHLEECILQKDGMVQKMSHGSNSS-
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE0 LYLRLVETSLKGERILGYAEEPCYLWFVMEFCEGGDLNQYVLSRRPDPATNKSFMLQLTS
:::.::::::::: : . ::::::.::.:::.:.:.:::.:. :: ::::::.:
NP_001 LYLQLVETSLKGE-IAFDPRSAYYLWFVMDFCDGGDMNEYLLSRKPNRKTNTSFMLQLSS
100 110 120 130 140 150
220 230 240 250 260
pF1KE0 AIAFLHKNHIVHRDLKPDNILITE-RSGT----PILKVADFGLSKVCAGLAPRGKEGNQD
:.::::::.:.:::::::::::.. : : : ::::::::::::.. :..
NP_001 ALAFLHKNQIIHRDLKPDNILISQTRLDTSDLEPTLKVADFGLSKVCSA------SGQNP
160 170 180 190 200
270 280 290 300 310 320
pF1KE0 NKNVNVNKYWLSSACGSDFYMAPEVWEGHYTAKADIFALGIIIWAMIERITFIDSETKKE
.. :.::: .::.:::.:::::::::::::::::::::::::::::.:::::::.:::::
NP_001 EEPVSVNKCFLSTACGTDFYMAPEVWEGHYTAKADIFALGIIIWAMLERITFIDTETKKE
210 220 230 240 250 260
330 340 350 360 370 380
pF1KE0 LLGTYIKQGTEIVPVGEALLENPKMELHIPQKRRTSMSEGIKQLLKDMLAANPQDRPDAF
:::.:.::::::::::::::::::::: :: :.. ::. .:::.:.:::::::::::::
NP_001 LLGSYVKQGTEIVPVGEALLENPKMELLIPVKKK-SMNGRMKQLIKEMLAANPQDRPDAF
270 280 290 300 310 320
390 400
pF1KE0 ELETRMDQVTCAA
::: :. :.
NP_001 ELELRLVQIAFKDSSWET
330 340
>>NP_690048 (OMIM: 610785) serine/threonine-protein kina (341 aa)
initn: 1491 init1: 527 opt: 1532 Z-score: 583.3 bits: 116.6 E(85289): 9.4e-26
Smith-Waterman score: 1532; 69.3% identity (87.0% similar) in 339 aa overlap (64-397:3-332)
40 50 60 70 80 90
pF1KE0 AAAARAMDPVAAEAPGEAFLARRRPEGGGGSARPRYSLLAEIGRGSYGVVYEAVAGRSGA
:..:.:.:. :.:::::::::::: ...:
NP_690 MVSSQPKYDLIREVGRGSYGVVYEAVIRKTSA
10 20 30
100 110 120 130 140 150
pF1KE0 RVAVKKIRCDAPENVELALAEFWALTSLKRRHQNVVQFEECVLQRNGLAQRMSHGNKSSQ
::::::::: ::::::::: :::::.:.: .: ::...:::.::..:..:.::::..::
NP_690 RVAVKKIRCHAPENVELALREFWALSSIKSQHPNVIHLEECILQKDGMVQKMSHGSNSS-
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE0 LYLRLVETSLKGERILGYAEEPCYLWFVMEFCEGGDLNQYVLSRRPDPATNKSFMLQLTS
:::.::::::::: : . ::::::.::.:::.:.:.:::.:. :: ::::::.:
NP_690 LYLQLVETSLKGE-IAFDPRSAYYLWFVMDFCDGGDMNEYLLSRKPNRKTNTSFMLQLSS
100 110 120 130 140 150
220 230 240 250 260
pF1KE0 AIAFLHKNHIVHRDLKPDNILITE-RSGT----PILKVADFGLSKVCAGLAPRGKEGNQD
:.::::::.:.:::::::::::.. : : : ::::::::::::.. :..
NP_690 ALAFLHKNQIIHRDLKPDNILISQTRLDTSDLEPTLKVADFGLSKVCSA------SGQNP
160 170 180 190 200
270 280 290 300 310 320
pF1KE0 NKNVNVNKYWLSSACGSDFYMAPEVWEGHYTAKADIFALGIIIWAMIERITFIDSETKKE
.. :.::: .::.:::.:::::::::::::::::::::::::::::.:::::::.:::::
NP_690 EEPVSVNKCFLSTACGTDFYMAPEVWEGHYTAKADIFALGIIIWAMLERITFIDTETKKE
210 220 230 240 250 260
330 340 350 360 370 380
pF1KE0 LLGTYIKQGTEIVPVGEALLENPKMELHIPQKRRTSMSEGIKQLLKDMLAANPQDRPDAF
:::.:.::::::::::::::::::::: :: :.. ::. .:::.:.:::::::::::::
NP_690 LLGSYVKQGTEIVPVGEALLENPKMELLIPVKKK-SMNGRMKQLIKEMLAANPQDRPDAF
270 280 290 300 310 320
390 400
pF1KE0 ELETRMDQVTCAA
::: :. :.
NP_690 ELELRLVQIAFKDSSWET
330 340
>>NP_001230462 (OMIM: 610785) serine/threonine-protein k (341 aa)
initn: 1491 init1: 527 opt: 1532 Z-score: 583.3 bits: 116.6 E(85289): 9.4e-26
Smith-Waterman score: 1532; 69.3% identity (87.0% similar) in 339 aa overlap (64-397:3-332)
40 50 60 70 80 90
pF1KE0 AAAARAMDPVAAEAPGEAFLARRRPEGGGGSARPRYSLLAEIGRGSYGVVYEAVAGRSGA
:..:.:.:. :.:::::::::::: ...:
NP_001 MVSSQPKYDLIREVGRGSYGVVYEAVIRKTSA
10 20 30
100 110 120 130 140 150
pF1KE0 RVAVKKIRCDAPENVELALAEFWALTSLKRRHQNVVQFEECVLQRNGLAQRMSHGNKSSQ
::::::::: ::::::::: :::::.:.: .: ::...:::.::..:..:.::::..::
NP_001 RVAVKKIRCHAPENVELALREFWALSSIKSQHPNVIHLEECILQKDGMVQKMSHGSNSS-
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE0 LYLRLVETSLKGERILGYAEEPCYLWFVMEFCEGGDLNQYVLSRRPDPATNKSFMLQLTS
:::.::::::::: : . ::::::.::.:::.:.:.:::.:. :: ::::::.:
NP_001 LYLQLVETSLKGE-IAFDPRSAYYLWFVMDFCDGGDMNEYLLSRKPNRKTNTSFMLQLSS
100 110 120 130 140 150
220 230 240 250 260
pF1KE0 AIAFLHKNHIVHRDLKPDNILITE-RSGT----PILKVADFGLSKVCAGLAPRGKEGNQD
:.::::::.:.:::::::::::.. : : : ::::::::::::.. :..
NP_001 ALAFLHKNQIIHRDLKPDNILISQTRLDTSDLEPTLKVADFGLSKVCSA------SGQNP
160 170 180 190 200
270 280 290 300 310 320
pF1KE0 NKNVNVNKYWLSSACGSDFYMAPEVWEGHYTAKADIFALGIIIWAMIERITFIDSETKKE
.. :.::: .::.:::.:::::::::::::::::::::::::::::.:::::::.:::::
NP_001 EEPVSVNKCFLSTACGTDFYMAPEVWEGHYTAKADIFALGIIIWAMLERITFIDTETKKE
210 220 230 240 250 260
330 340 350 360 370 380
pF1KE0 LLGTYIKQGTEIVPVGEALLENPKMELHIPQKRRTSMSEGIKQLLKDMLAANPQDRPDAF
:::.:.::::::::::::::::::::: :: :.. ::. .:::.:.:::::::::::::
NP_001 LLGSYVKQGTEIVPVGEALLENPKMELLIPVKKK-SMNGRMKQLIKEMLAANPQDRPDAF
270 280 290 300 310 320
390 400
pF1KE0 ELETRMDQVTCAA
::: :. :.
NP_001 ELELRLVQIAFKDSSWET
330 340
>>XP_011539094 (OMIM: 610785) PREDICTED: serine/threonin (257 aa)
initn: 1129 init1: 527 opt: 1112 Z-score: 435.4 bits: 88.8 E(85289): 1.6e-17
Smith-Waterman score: 1112; 69.2% identity (85.4% similar) in 253 aa overlap (150-397:4-248)
120 130 140 150 160 170
pF1KE0 SLKRRHQNVVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEEPCYLW
.:...: .::::::::: : . :::
XP_011 MRGRSGSVYPELVETSLKGE-IAFDPRSAYYLW
10 20 30
180 190 200 210 220 230
pF1KE0 FVMEFCEGGDLNQYVLSRRPDPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNILITE-R
:::.::.:::.:.:.:::.:. :: ::::::.::.::::::.:.:::::::::::.. :
XP_011 FVMDFCDGGDMNEYLLSRKPNRKTNTSFMLQLSSALAFLHKNQIIHRDLKPDNILISQTR
40 50 60 70 80 90
240 250 260 270 280 290
pF1KE0 SGT----PILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAPEVW
: : ::::::::::::.. :.. .. :.::: .::.:::.:::::::::
XP_011 LDTSDLEPTLKVADFGLSKVCSA------SGQNPEEPVSVNKCFLSTACGTDFYMAPEVW
100 110 120 130 140
300 310 320 330 340 350
pF1KE0 EGHYTAKADIFALGIIIWAMIERITFIDSETKKELLGTYIKQGTEIVPVGEALLENPKME
::::::::::::::::::::.:::::::.::::::::.:.::::::::::::::::::::
XP_011 EGHYTAKADIFALGIIIWAMLERITFIDTETKKELLGSYVKQGTEIVPVGEALLENPKME
150 160 170 180 190 200
360 370 380 390 400
pF1KE0 LHIPQKRRTSMSEGIKQLLKDMLAANPQDRPDAFELETRMDQVTCAA
: :: :.. ::. .:::.:.:::::::::::::::: :. :.
XP_011 LLIPVKKK-SMNGRMKQLIKEMLAANPQDRPDAFELELRLVQIAFKDSSWET
210 220 230 240 250
>>XP_006710444 (OMIM: 610785) PREDICTED: serine/threonin (263 aa)
initn: 1116 init1: 527 opt: 1099 Z-score: 430.7 bits: 88.0 E(85289): 3e-17
Smith-Waterman score: 1099; 70.6% identity (85.3% similar) in 245 aa overlap (158-397:18-254)
130 140 150 160 170 180
pF1KE0 VVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEEPCYLWFVMEFCEG
::::::::: : . ::::::.::.:
XP_006 MHRAFHPSEPRTPARSSLVETSLKGE-IAFDPRSAYYLWFVMDFCDG
10 20 30 40
190 200 210 220 230 240
pF1KE0 GDLNQYVLSRRPDPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNILITE-RSGT----P
::.:.:.:::.:. :: ::::::.::.::::::.:.:::::::::::.. : : :
XP_006 GDMNEYLLSRKPNRKTNTSFMLQLSSALAFLHKNQIIHRDLKPDNILISQTRLDTSDLEP
50 60 70 80 90 100
250 260 270 280 290 300
pF1KE0 ILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAPEVWEGHYTAKA
::::::::::::.. :.. .. :.::: .::.:::.:::::::::::::::::
XP_006 TLKVADFGLSKVCSA------SGQNPEEPVSVNKCFLSTACGTDFYMAPEVWEGHYTAKA
110 120 130 140 150 160
310 320 330 340 350 360
pF1KE0 DIFALGIIIWAMIERITFIDSETKKELLGTYIKQGTEIVPVGEALLENPKMELHIPQKRR
::::::::::::.:::::::.::::::::.:.::::::::::::::::::::: :: :..
XP_006 DIFALGIIIWAMLERITFIDTETKKELLGSYVKQGTEIVPVGEALLENPKMELLIPVKKK
170 180 190 200 210 220
370 380 390 400
pF1KE0 TSMSEGIKQLLKDMLAANPQDRPDAFELETRMDQVTCAA
::. .:::.:.:::::::::::::::: :. :.
XP_006 -SMNGRMKQLIKEMLAANPQDRPDAFELELRLVQIAFKDSSWET
230 240 250 260
>>XP_011527476 (OMIM: 609370) PREDICTED: serine/threonin (430 aa)
initn: 1080 init1: 1080 opt: 1088 Z-score: 424.3 bits: 87.5 E(85289): 6.8e-17
Smith-Waterman score: 1088; 98.8% identity (99.4% similar) in 170 aa overlap (1-170:230-398)
10 20 30
pF1KE0 METGKDGARRGTQSPERKRRSPVPRAPSTK
::::::::::::::::::::::::::::::
XP_011 PAPPRPRAGRRDEAGGARAAPLLLPPPPAAMETGKDGARRGTQSPERKRRSPVPRAPSTK
200 210 220 230 240 250
40 50 60 70 80 90
pF1KE0 LRPAAAARAMDPVAAEAPGEAFLARRRPEGGGGSARPRYSLLAEIGRGSYGVVYEAVAGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRPAAAARAMDPVAAEAPGEAFLARRRPEGGGGSARPRYSLLAEIGRGSYGVVYEAVAGR
260 270 280 290 300 310
100 110 120 130 140 150
pF1KE0 SGARVAVKKIRCDAPENVELALAEFWALTSLKRRHQNVVQFEECVLQRNGLAQRMSHGNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGARVAVKKIRCDAPENVELALAEFWALTSLKRRHQNVVQFEECVLQRNGLAQRMSHGNK
320 330 340 350 360 370
160 170 180 190 200 210
pF1KE0 SSQLYLRLVETSLKGERILGYAEEPCYLWFVMEFCEGGDLNQYVLSRRPDPATNKSFMLQ
::::::::::::::: :.::
XP_011 SSQLYLRLVETSLKG-RFLGTHSLTTSPPEDGRGYRWWPGRLAISRQLDPAM
380 390 400 410 420 430
401 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 17:59:20 2016 done: Sat Nov 5 17:59:21 2016
Total Scan time: 9.350 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]