FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0692, 402 aa 1>>>pF1KE0692 402 - 402 aa - 402 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.4082+/-0.00081; mu= 8.4050+/- 0.049 mean_var=153.4582+/-32.433, 0's: 0 Z-trim(113.4): 135 B-trim: 353 in 1/52 Lambda= 0.103533 statistics sampled from 13911 (14073) to 13911 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.772), E-opt: 0.2 (0.432), width: 16 Scan time: 3.260 The best scores are: opt bits E(32554) CCDS2662.1 STAC gene_id:6769|Hs108|chr3 ( 402) 2737 420.3 1.6e-117 CCDS77722.1 STAC gene_id:6769|Hs108|chr3 ( 341) 1451 228.1 9.5e-60 CCDS11335.1 STAC2 gene_id:342667|Hs108|chr17 ( 411) 979 157.7 1.8e-38 CCDS66405.1 STAC3 gene_id:246329|Hs108|chr12 ( 178) 431 75.6 4.2e-14 CCDS66406.1 STAC3 gene_id:246329|Hs108|chr12 ( 325) 431 75.8 6.6e-14 CCDS8936.1 STAC3 gene_id:246329|Hs108|chr12 ( 364) 431 75.8 7.3e-14 >>CCDS2662.1 STAC gene_id:6769|Hs108|chr3 (402 aa) initn: 2737 init1: 2737 opt: 2737 Z-score: 2223.3 bits: 420.3 E(32554): 1.6e-117 Smith-Waterman score: 2737; 99.8% identity (100.0% similar) in 402 aa overlap (1-402:1-402) 10 20 30 40 50 60 pF1KE0 MIPPSSPREDGVDGLPKEAVGAEQPPSPASTSSQESKLQKLKRSLSFKTKSLRSKSADNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS26 MIPPSSPREDGVDGLPKEAVGAEQPPSPASTSSQESKLQKLKRSLSFKTKSLRSKSADNF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 FQRTNSEDMKLQAHMVAEISPSSSPLPAPGSLTSTPARAGLHPGGKAHAFHEYIFKKPTF ::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::: CCDS26 FQRTNSEDMKLQAHMVAEISPSSSPLPAPGSLTSTPARAGLHPGGKAHAFQEYIFKKPTF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 CDVCNHMIVGTNAKHGLRCKACKMSIHHKCTDGLAPQRCMGKLPKGFRRYYSSPLLIHEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS26 CDVCNHMIVGTNAKHGLRCKACKMSIHHKCTDGLAPQRCMGKLPKGFRRYYSSPLLIHEQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 FGCIKEVMPIACGNKVDPVYETLRFGTSLAQRTKKGSSGSGSDSPHRTSTSDLVEVPEEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS26 FGCIKEVMPIACGNKVDPVYETLRFGTSLAQRTKKGSSGSGSDSPHRTSTSDLVEVPEEA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 NGPGGGYDLRKRSNSVFTYPENGTDDFRDPAKNINHQGSLSKDPLQMNTYVALYKFVPQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS26 NGPGGGYDLRKRSNSVFTYPENGTDDFRDPAKNINHQGSLSKDPLQMNTYVALYKFVPQE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 NEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQQNEKIFRCVRTFIGCKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS26 NEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQQNEKIFRCVRTFIGCKE 310 320 330 340 350 360 370 380 390 400 pF1KE0 QGQITLKENQICVSSEEEQDGFIRVLSGKKKGLIPLDVLENI :::::::::::::::::::::::::::::::::::::::::: CCDS26 QGQITLKENQICVSSEEEQDGFIRVLSGKKKGLIPLDVLENI 370 380 390 400 >>CCDS77722.1 STAC gene_id:6769|Hs108|chr3 (341 aa) initn: 1442 init1: 1442 opt: 1451 Z-score: 1186.2 bits: 228.1 E(32554): 9.5e-60 Smith-Waterman score: 2158; 84.6% identity (84.8% similar) in 402 aa overlap (1-402:1-341) 10 20 30 40 50 60 pF1KE0 MIPPSSPREDGVDGLPKEAVGAEQPPSPASTSSQESKLQKLKRSLSFKTKSLRSKSADNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS77 MIPPSSPREDGVDGLPKEAVGAEQPPSPASTSSQESKLQKLKRSLSFKTKSLRSKSADNF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 FQRTNSEDMKLQAHMVAEISPSSSPLPAPGSLTSTPARAGLHPGGKAHAFHEYIFKKPTF ::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::: CCDS77 FQRTNSEDMKLQAHMVAEISPSSSPLPAPGSLTSTPARAGLHPGGKAHAFQEYIFKKPTF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 CDVCNHMIVGTNAKHGLRCKACKMSIHHKCTDGLAPQRCMGKLPKGFRRYYSSPLLIHEQ ::::::::: CCDS77 CDVCNHMIV--------------------------------------------------- 190 200 210 220 230 240 pF1KE0 FGCIKEVMPIACGNKVDPVYETLRFGTSLAQRTKKGSSGSGSDSPHRTSTSDLVEVPEEA :::::::::::::::::::::::::::::::::::::::::::::::::: CCDS77 ----------ACGNKVDPVYETLRFGTSLAQRTKKGSSGSGSDSPHRTSTSDLVEVPEEA 130 140 150 160 170 250 260 270 280 290 300 pF1KE0 NGPGGGYDLRKRSNSVFTYPENGTDDFRDPAKNINHQGSLSKDPLQMNTYVALYKFVPQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS77 NGPGGGYDLRKRSNSVFTYPENGTDDFRDPAKNINHQGSLSKDPLQMNTYVALYKFVPQE 180 190 200 210 220 230 310 320 330 340 350 360 pF1KE0 NEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQQNEKIFRCVRTFIGCKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS77 NEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQQNEKIFRCVRTFIGCKE 240 250 260 270 280 290 370 380 390 400 pF1KE0 QGQITLKENQICVSSEEEQDGFIRVLSGKKKGLIPLDVLENI :::::::::::::::::::::::::::::::::::::::::: CCDS77 QGQITLKENQICVSSEEEQDGFIRVLSGKKKGLIPLDVLENI 300 310 320 330 340 >>CCDS11335.1 STAC2 gene_id:342667|Hs108|chr17 (411 aa) initn: 961 init1: 452 opt: 979 Z-score: 804.1 bits: 157.7 E(32554): 1.8e-38 Smith-Waterman score: 1084; 46.1% identity (70.8% similar) in 414 aa overlap (16-402:11-411) 10 20 30 40 50 60 pF1KE0 MIPPSSPREDGVDGLPKEAVGAEQPPSPASTSSQESKLQKLKRSLSFKTKSLRSKSADNF : .:. ...::. .: . ::.:::..:::::.:: ::::: .:: CCDS11 MTEMSEKENEPDDAA-THSPPGTVS-ALQETKLQRFKRSLSLKTI-LRSKSLENF 10 20 30 40 50 70 80 90 100 pF1KE0 FQRTNSEDMKLQAH-MVAEISPSSSPLPAP-----GSLTSTPAR-------AGLHPGGKA : :..:: .: .. ... .: : : : : : .:. :.:.: . CCDS11 FLRSGSE-LKCPTEVLLTPPTPLPPPSPPPTASDRGLATPSPSPCPVPRPLAALKPV-RL 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE0 HAFHEYIFKKPTFCDVCNHMIVGTNAKHGLRCKACKMSIHHKCTDGLAPQRCMGKLPKGF :.:.:..::. . :..:...::: :.:.::::: ::.:.: :.. .. :.: :: .: CCDS11 HSFQEHVFKRASPCELCHQLIVG-NSKQGLRCKMCKVSVHLWCSEEISHQQCPGKTSTSF 120 130 140 150 160 170 180 190 200 210 220 pF1KE0 RRYYSSPLLIHEQFG-CI--KEVMPIACGNKVDPVYETLRFGTSLAQRTKKGSSGSGSDS :: .:::::.:: : :: : . ..::::::::::.::::: ...: .: :.: CCDS11 RRNFSSPLLVHEPPPVCATSKESPPTGDSGKVDPVYETLRYGTSLAL-MNRSSFSSTSES 170 180 190 200 210 220 230 240 250 260 270 pF1KE0 PHRTSTSDLVEVPEEANGP------GGGYDLRKRSNSVFTYP---ENGTDDFRDPAKNIN : : : :. :. :...: : : .. ::: : :. . ..:.... CCDS11 PTR-SLSERDELTEDGEGSIRSSEEGPG----DSASPVFTAPAESEGPGPEEKSPGQQLP 230 240 250 260 270 280 280 290 300 310 320 330 pF1KE0 HQGSLSKDPLQMNTYVALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFP ...: :: : .:::::::.::::.:: ..::: : :..::::::::::: ::.:::: CCDS11 -KATLRKDVGPMYSYVALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFP 290 300 310 320 330 340 340 350 360 370 380 390 pF1KE0 ANFVQRLQQNEKIFRCVRTFIGCKEQGQITLKENQICVS--SEEEQDGFIRVLSGKKKGL ::::::.. .:...:: . : : :::: ..::::::::. .. :::::: ::::.:: CCDS11 ANFVQRVRPGENVWRCCQPFSGNKEQGYMSLKENQICVGVGRSKDADGFIRVSSGKKRGL 350 360 370 380 390 400 400 pF1KE0 IPLDVLENI .:.:.: .: CCDS11 VPVDALTEI 410 >>CCDS66405.1 STAC3 gene_id:246329|Hs108|chr12 (178 aa) initn: 417 init1: 417 opt: 431 Z-score: 366.7 bits: 75.6 E(32554): 4.2e-14 Smith-Waterman score: 431; 41.7% identity (76.4% similar) in 144 aa overlap (260-402:35-178) 230 240 250 260 270 280 pF1KE0 TSDLVEVPEEANGPGGGYDLRKRSNSVFTYPENGTDDFRDPAKNINHQGSLSKDPLQMNT :..:. . :.. . . . .. .:.. CCDS66 ERKKGQADKKNPVAAMMEEEPESARPEEGKPQDGNPEGDKKAEKKTPDDKHKQPGFQQSH 10 20 30 40 50 60 290 300 310 320 330 340 pF1KE0 Y-VALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQQNEKI : ::::.: :..::.. ::. ::...::::.::.::: ...:::: ::. :.. .:.. CCDS66 YFVALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNFIIRVRAGERV 70 80 90 100 110 120 350 360 370 380 390 400 pF1KE0 FRCVRTFIGCKEQGQITLKENQICVSSEEEQDGFIRVLSGKKKGLIPLDVLENI : .:.:.: .: ::::::..:: :.. .: :...: .:.: ::.: : ::.: CCDS66 HRVTRSFVGNREIGQITLKKDQIVVQKGDEAGGYVKVYTGRKVGLFPTDFLEEI 130 140 150 160 170 >>CCDS66406.1 STAC3 gene_id:246329|Hs108|chr12 (325 aa) initn: 692 init1: 417 opt: 431 Z-score: 363.1 bits: 75.8 E(32554): 6.6e-14 Smith-Waterman score: 797; 40.9% identity (69.8% similar) in 298 aa overlap (106-402:49-325) 80 90 100 110 120 130 pF1KE0 VAEISPSSSPLPAPGSLTSTPARAGLHPGGKAHAFHEYIFKKPTFCDVCNHMIVGTNAKH : : :....:::: ::::: .::: : : CCDS66 GPIYYIYEEEEEEEEEEEEPPPEPPKLVNDKPHKFKDHFFKKPKFCDVCARMIV-LNNKF 20 30 40 50 60 70 140 150 160 170 180 190 pF1KE0 GLRCKACKMSIHHKCTDGLAPQRCMGKLPKGFRRYYSSPLLIHEQFGCIKEVMPIACGNK ::::: :: .::..: . . :::.::.: ::.: ::::: ..:..:.:. .. .:. CCDS66 GLRCKNCKTNIHEHCQSYVEMQRCFGKIPPGFHRAYSSPLYSNQQYACVKD---LSAANR 80 90 100 110 120 130 200 210 220 230 240 250 pF1KE0 VDPVYETLRFGTSLAQRTKKGSSGSGSDSPHRTSTSDLVEVPEEANGPGGGYDLRKRSNS :::.:::: :. .:.. .: .:. . . .. . : :: : : : CCDS66 NDPVFETLRTGVIMANKERK----KGQADKKNPVAAMMEEEPESAR-PEEGK-------- 140 150 160 170 180 260 270 280 290 300 310 pF1KE0 VFTYPENGTDDFRDPAKNINHQGSLSKDPLQMNTY-VALYKFVPQENEDLEMRPGDIITL :..:. . :.. . . . .. .:.. : ::::.: :..::.. ::. ::. CCDS66 ----PQDGNPEGDKKAEKKTPDDKHKQPGFQQSHYFVALYRFKALEKDDLDFPPGEKITV 190 200 210 220 230 320 330 340 350 360 370 pF1KE0 LEDSNEDWWKGKIQDRIGFFPANFVQRLQQNEKIFRCVRTFIGCKEQGQITLKENQICVS ..::::.::.::: ...:::: ::. :.. .:.. : .:.:.: .: ::::::..:: :. CCDS66 IDDSNEEWWRGKIGEKVGFFPPNFIIRVRAGERVHRVTRSFVGNREIGQITLKKDQIVVQ 240 250 260 270 280 290 380 390 400 pF1KE0 SEEEQDGFIRVLSGKKKGLIPLDVLENI . .: :...: .:.: ::.: : ::.: CCDS66 KGDEAGGYVKVYTGRKVGLFPTDFLEEI 300 310 320 >>CCDS8936.1 STAC3 gene_id:246329|Hs108|chr12 (364 aa) initn: 692 init1: 417 opt: 431 Z-score: 362.4 bits: 75.8 E(32554): 7.3e-14 Smith-Waterman score: 807; 36.0% identity (63.2% similar) in 394 aa overlap (17-402:4-364) 10 20 30 40 50 pF1KE0 MIPPSSPREDGVDGLPKEAVGAEQPPSPASTSSQESKLQKLKRSL---SFKTKSLR---- ::.. . .: :: : ..: ::.::. : : :: .. CCDS89 MTEKEVLESPKPSFPAET--RQSGLQRLKQLLRKGSTGTKEMELPPE 10 20 30 40 60 70 80 90 100 110 pF1KE0 SKSADNFFQRTNSEDMKLQAHMVAEISPSSSPLPAPGSLTSTPARAGLHPGGKAHAFHEY .. . .. . . . : : : : .:.. : : :... CCDS89 PQANGEAVGAGGGPIYYIYEEEEEEEEEEEEPPPEPPKLVND----------KPHKFKDH 50 60 70 80 90 120 130 140 150 160 170 pF1KE0 IFKKPTFCDVCNHMIVGTNAKHGLRCKACKMSIHHKCTDGLAPQRCMGKLPKGFRRYYSS .:::: ::::: .::: : : ::::: :: .::..: . . :::.::.: ::.: ::: CCDS89 FFKKPKFCDVCARMIV-LNNKFGLRCKNCKTNIHEHCQSYVEMQRCFGKIPPGFHRAYSS 100 110 120 130 140 150 180 190 200 210 220 230 pF1KE0 PLLIHEQFGCIKEVMPIACGNKVDPVYETLRFGTSLAQRTKKGSSGSGSDSPHRTSTSDL :: ..:..:.:. .. .:. :::.:::: :. .:.. .: .:. . . .. . CCDS89 PLYSNQQYACVKD---LSAANRNDPVFETLRTGVIMANKERK----KGQADKKNPVAAMM 160 170 180 190 200 240 250 260 270 280 290 pF1KE0 VEVPEEANGPGGGYDLRKRSNSVFTYPENGTDDFRDPAKNINHQGSLSKDPLQMNTY-VA : :: : : : :..:. . :.. . . . .. .:.. : :: CCDS89 EEEPESAR-PEEGK------------PQDGNPEGDKKAEKKTPDDKHKQPGFQQSHYFVA 210 220 230 240 250 300 310 320 330 340 350 pF1KE0 LYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQQNEKIFRCV ::.: :..::.. ::. ::...::::.::.::: ...:::: ::. :.. .:.. : . CCDS89 LYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNFIIRVRAGERVHRVT 260 270 280 290 300 310 360 370 380 390 400 pF1KE0 RTFIGCKEQGQITLKENQICVSSEEEQDGFIRVLSGKKKGLIPLDVLENI :.:.: .: ::::::..:: :.. .: :...: .:.: ::.: : ::.: CCDS89 RSFVGNREIGQITLKKDQIVVQKGDEAGGYVKVYTGRKVGLFPTDFLEEI 320 330 340 350 360 402 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 08:03:25 2016 done: Sat Nov 5 08:03:26 2016 Total Scan time: 3.260 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]