FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0693, 282 aa 1>>>pF1KE0693 282 - 282 aa - 282 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.7764+/-0.000517; mu= 9.3667+/- 0.033 mean_var=428.4206+/-91.902, 0's: 0 Z-trim(119.9): 132 B-trim: 1660 in 1/55 Lambda= 0.061964 statistics sampled from 34244 (34413) to 34244 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.709), E-opt: 0.2 (0.403), width: 16 Scan time: 6.670 The best scores are: opt bits E(85289) NP_037425 (OMIM: 602718) transformer-2 protein hom ( 282) 1933 186.5 5e-47 XP_016867578 (OMIM: 602718) PREDICTED: transformer ( 181) 1268 126.7 3.2e-29 XP_016867579 (OMIM: 602718) PREDICTED: transformer ( 181) 1268 126.7 3.2e-29 NP_001269687 (OMIM: 602718) transformer-2 protein ( 181) 1268 126.7 3.2e-29 XP_005249782 (OMIM: 602718) PREDICTED: transformer ( 181) 1268 126.7 3.2e-29 NP_001269686 (OMIM: 602718) transformer-2 protein ( 181) 1268 126.7 3.2e-29 NP_001269688 (OMIM: 602718) transformer-2 protein ( 180) 1249 125.0 1e-28 NP_004584 (OMIM: 602719) transformer-2 protein hom ( 288) 1163 117.6 2.7e-26 NP_001230808 (OMIM: 602719) transformer-2 protein ( 188) 838 88.3 1.2e-17 XP_005247760 (OMIM: 602719) PREDICTED: transformer ( 188) 838 88.3 1.2e-17 XP_016862522 (OMIM: 602719) PREDICTED: transformer ( 188) 838 88.3 1.2e-17 XP_011511374 (OMIM: 602719) PREDICTED: transformer ( 188) 838 88.3 1.2e-17 XP_011513633 (OMIM: 602718) PREDICTED: transformer ( 219) 806 85.5 9.5e-17 NP_001287744 (OMIM: 602649) cold-inducible RNA-bin ( 168) 328 42.6 0.00061 XP_016881726 (OMIM: 602649) PREDICTED: cold-induci ( 168) 328 42.6 0.00061 NP_001271 (OMIM: 602649) cold-inducible RNA-bindin ( 172) 328 42.6 0.00061 XP_006722700 (OMIM: 602649) PREDICTED: cold-induci ( 172) 328 42.6 0.00061 XP_011525970 (OMIM: 602649) PREDICTED: cold-induci ( 202) 328 42.7 0.00066 NP_001287758 (OMIM: 602649) cold-inducible RNA-bin ( 297) 328 43.0 0.0008 NP_001287998 (OMIM: 180740) U1 small nuclear ribon ( 428) 328 43.3 0.00095 NP_003080 (OMIM: 180740) U1 small nuclear ribonucl ( 437) 320 42.6 0.0016 NP_006734 (OMIM: 300027) RNA-binding protein 3 [Ho ( 157) 302 40.2 0.0029 NP_003007 (OMIM: 600813) serine/arginine-rich spli ( 221) 286 39.0 0.0094 NP_001182356 (OMIM: 600813) serine/arginine-rich s ( 221) 286 39.0 0.0094 XP_016880431 (OMIM: 600813) PREDICTED: serine/argi ( 221) 286 39.0 0.0094 >>NP_037425 (OMIM: 602718) transformer-2 protein homolog (282 aa) initn: 1933 init1: 1933 opt: 1933 Z-score: 965.2 bits: 186.5 E(85289): 5e-47 Smith-Waterman score: 1933; 100.0% identity (100.0% similar) in 282 aa overlap (1-282:1-282) 10 20 30 40 50 60 pF1KE0 MSDVEENNFEGRESRSQSKSPTGTPARVKSESRSGSRSPSRVSKHSESHSRSRSKSRSRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 MSDVEENNFEGRESRSQSKSPTGTPARVKSESRSGSRSPSRVSKHSESHSRSRSKSRSRS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 RRHSHRRYTRSRSHSHSHRRRSRSRSYTPEYRRRRSRSHSPMSNRRRHTGSRANPDPNTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 RRHSHRRYTRSRSHSHSHRRRSRSRSYTPEYRRRRSRSHSPMSNRRRHTGSRANPDPNTC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 LGVFGLSLYTTERDLREVFSRYGPLSGVNVVYDQRTGRSRGFAFVYFERIDDSKEAMERA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 LGVFGLSLYTTERDLREVFSRYGPLSGVNVVYDQRTGRSRGFAFVYFERIDDSKEAMERA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 NGMELDGRRIRVDYSITKRAHTPTPGIYMGRPTHSGGGGGGGGGGGGGGGGRRRDSYYDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 NGMELDGRRIRVDYSITKRAHTPTPGIYMGRPTHSGGGGGGGGGGGGGGGGRRRDSYYDR 190 200 210 220 230 240 250 260 270 280 pF1KE0 GYDRGYDRYEDYDYRYRRRSPSPYYSRYRSRSRSRSYSPRRY :::::::::::::::::::::::::::::::::::::::::: NP_037 GYDRGYDRYEDYDYRYRRRSPSPYYSRYRSRSRSRSYSPRRY 250 260 270 280 >>XP_016867578 (OMIM: 602718) PREDICTED: transformer-2 p (181 aa) initn: 1268 init1: 1268 opt: 1268 Z-score: 645.6 bits: 126.7 E(85289): 3.2e-29 Smith-Waterman score: 1268; 100.0% identity (100.0% similar) in 181 aa overlap (102-282:1-181) 80 90 100 110 120 130 pF1KE0 RSHSHSHRRRSRSRSYTPEYRRRRSRSHSPMSNRRRHTGSRANPDPNTCLGVFGLSLYTT :::::::::::::::::::::::::::::: XP_016 MSNRRRHTGSRANPDPNTCLGVFGLSLYTT 10 20 30 140 150 160 170 180 190 pF1KE0 ERDLREVFSRYGPLSGVNVVYDQRTGRSRGFAFVYFERIDDSKEAMERANGMELDGRRIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ERDLREVFSRYGPLSGVNVVYDQRTGRSRGFAFVYFERIDDSKEAMERANGMELDGRRIR 40 50 60 70 80 90 200 210 220 230 240 250 pF1KE0 VDYSITKRAHTPTPGIYMGRPTHSGGGGGGGGGGGGGGGGRRRDSYYDRGYDRGYDRYED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VDYSITKRAHTPTPGIYMGRPTHSGGGGGGGGGGGGGGGGRRRDSYYDRGYDRGYDRYED 100 110 120 130 140 150 260 270 280 pF1KE0 YDYRYRRRSPSPYYSRYRSRSRSRSYSPRRY ::::::::::::::::::::::::::::::: XP_016 YDYRYRRRSPSPYYSRYRSRSRSRSYSPRRY 160 170 180 >>XP_016867579 (OMIM: 602718) PREDICTED: transformer-2 p (181 aa) initn: 1268 init1: 1268 opt: 1268 Z-score: 645.6 bits: 126.7 E(85289): 3.2e-29 Smith-Waterman score: 1268; 100.0% identity (100.0% similar) in 181 aa overlap (102-282:1-181) 80 90 100 110 120 130 pF1KE0 RSHSHSHRRRSRSRSYTPEYRRRRSRSHSPMSNRRRHTGSRANPDPNTCLGVFGLSLYTT :::::::::::::::::::::::::::::: XP_016 MSNRRRHTGSRANPDPNTCLGVFGLSLYTT 10 20 30 140 150 160 170 180 190 pF1KE0 ERDLREVFSRYGPLSGVNVVYDQRTGRSRGFAFVYFERIDDSKEAMERANGMELDGRRIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ERDLREVFSRYGPLSGVNVVYDQRTGRSRGFAFVYFERIDDSKEAMERANGMELDGRRIR 40 50 60 70 80 90 200 210 220 230 240 250 pF1KE0 VDYSITKRAHTPTPGIYMGRPTHSGGGGGGGGGGGGGGGGRRRDSYYDRGYDRGYDRYED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VDYSITKRAHTPTPGIYMGRPTHSGGGGGGGGGGGGGGGGRRRDSYYDRGYDRGYDRYED 100 110 120 130 140 150 260 270 280 pF1KE0 YDYRYRRRSPSPYYSRYRSRSRSRSYSPRRY ::::::::::::::::::::::::::::::: XP_016 YDYRYRRRSPSPYYSRYRSRSRSRSYSPRRY 160 170 180 >>NP_001269687 (OMIM: 602718) transformer-2 protein homo (181 aa) initn: 1268 init1: 1268 opt: 1268 Z-score: 645.6 bits: 126.7 E(85289): 3.2e-29 Smith-Waterman score: 1268; 100.0% identity (100.0% similar) in 181 aa overlap (102-282:1-181) 80 90 100 110 120 130 pF1KE0 RSHSHSHRRRSRSRSYTPEYRRRRSRSHSPMSNRRRHTGSRANPDPNTCLGVFGLSLYTT :::::::::::::::::::::::::::::: NP_001 MSNRRRHTGSRANPDPNTCLGVFGLSLYTT 10 20 30 140 150 160 170 180 190 pF1KE0 ERDLREVFSRYGPLSGVNVVYDQRTGRSRGFAFVYFERIDDSKEAMERANGMELDGRRIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERDLREVFSRYGPLSGVNVVYDQRTGRSRGFAFVYFERIDDSKEAMERANGMELDGRRIR 40 50 60 70 80 90 200 210 220 230 240 250 pF1KE0 VDYSITKRAHTPTPGIYMGRPTHSGGGGGGGGGGGGGGGGRRRDSYYDRGYDRGYDRYED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VDYSITKRAHTPTPGIYMGRPTHSGGGGGGGGGGGGGGGGRRRDSYYDRGYDRGYDRYED 100 110 120 130 140 150 260 270 280 pF1KE0 YDYRYRRRSPSPYYSRYRSRSRSRSYSPRRY ::::::::::::::::::::::::::::::: NP_001 YDYRYRRRSPSPYYSRYRSRSRSRSYSPRRY 160 170 180 >>XP_005249782 (OMIM: 602718) PREDICTED: transformer-2 p (181 aa) initn: 1268 init1: 1268 opt: 1268 Z-score: 645.6 bits: 126.7 E(85289): 3.2e-29 Smith-Waterman score: 1268; 100.0% identity (100.0% similar) in 181 aa overlap (102-282:1-181) 80 90 100 110 120 130 pF1KE0 RSHSHSHRRRSRSRSYTPEYRRRRSRSHSPMSNRRRHTGSRANPDPNTCLGVFGLSLYTT :::::::::::::::::::::::::::::: XP_005 MSNRRRHTGSRANPDPNTCLGVFGLSLYTT 10 20 30 140 150 160 170 180 190 pF1KE0 ERDLREVFSRYGPLSGVNVVYDQRTGRSRGFAFVYFERIDDSKEAMERANGMELDGRRIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ERDLREVFSRYGPLSGVNVVYDQRTGRSRGFAFVYFERIDDSKEAMERANGMELDGRRIR 40 50 60 70 80 90 200 210 220 230 240 250 pF1KE0 VDYSITKRAHTPTPGIYMGRPTHSGGGGGGGGGGGGGGGGRRRDSYYDRGYDRGYDRYED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VDYSITKRAHTPTPGIYMGRPTHSGGGGGGGGGGGGGGGGRRRDSYYDRGYDRGYDRYED 100 110 120 130 140 150 260 270 280 pF1KE0 YDYRYRRRSPSPYYSRYRSRSRSRSYSPRRY ::::::::::::::::::::::::::::::: XP_005 YDYRYRRRSPSPYYSRYRSRSRSRSYSPRRY 160 170 180 >>NP_001269686 (OMIM: 602718) transformer-2 protein homo (181 aa) initn: 1268 init1: 1268 opt: 1268 Z-score: 645.6 bits: 126.7 E(85289): 3.2e-29 Smith-Waterman score: 1268; 100.0% identity (100.0% similar) in 181 aa overlap (102-282:1-181) 80 90 100 110 120 130 pF1KE0 RSHSHSHRRRSRSRSYTPEYRRRRSRSHSPMSNRRRHTGSRANPDPNTCLGVFGLSLYTT :::::::::::::::::::::::::::::: NP_001 MSNRRRHTGSRANPDPNTCLGVFGLSLYTT 10 20 30 140 150 160 170 180 190 pF1KE0 ERDLREVFSRYGPLSGVNVVYDQRTGRSRGFAFVYFERIDDSKEAMERANGMELDGRRIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERDLREVFSRYGPLSGVNVVYDQRTGRSRGFAFVYFERIDDSKEAMERANGMELDGRRIR 40 50 60 70 80 90 200 210 220 230 240 250 pF1KE0 VDYSITKRAHTPTPGIYMGRPTHSGGGGGGGGGGGGGGGGRRRDSYYDRGYDRGYDRYED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VDYSITKRAHTPTPGIYMGRPTHSGGGGGGGGGGGGGGGGRRRDSYYDRGYDRGYDRYED 100 110 120 130 140 150 260 270 280 pF1KE0 YDYRYRRRSPSPYYSRYRSRSRSRSYSPRRY ::::::::::::::::::::::::::::::: NP_001 YDYRYRRRSPSPYYSRYRSRSRSRSYSPRRY 160 170 180 >>NP_001269688 (OMIM: 602718) transformer-2 protein homo (180 aa) initn: 1236 init1: 1102 opt: 1249 Z-score: 636.5 bits: 125.0 E(85289): 1e-28 Smith-Waterman score: 1249; 99.4% identity (99.4% similar) in 181 aa overlap (102-282:1-180) 80 90 100 110 120 130 pF1KE0 RSHSHSHRRRSRSRSYTPEYRRRRSRSHSPMSNRRRHTGSRANPDPNTCLGVFGLSLYTT :::::::::::::::::::::::::::::: NP_001 MSNRRRHTGSRANPDPNTCLGVFGLSLYTT 10 20 30 140 150 160 170 180 190 pF1KE0 ERDLREVFSRYGPLSGVNVVYDQRTGRSRGFAFVYFERIDDSKEAMERANGMELDGRRIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERDLREVFSRYGPLSGVNVVYDQRTGRSRGFAFVYFERIDDSKEAMERANGMELDGRRIR 40 50 60 70 80 90 200 210 220 230 240 250 pF1KE0 VDYSITKRAHTPTPGIYMGRPTHSGGGGGGGGGGGGGGGGRRRDSYYDRGYDRGYDRYED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VDYSITKRAHTPTPGIYMGRPTHSGGGGGGGGGGGGGGGGRRRDSYYDRGYDRGYDRYED 100 110 120 130 140 150 260 270 280 pF1KE0 YDYRYRRRSPSPYYSRYRSRSRSRSYSPRRY ::::::: ::::::::::::::::::::::: NP_001 YDYRYRR-SPSPYYSRYRSRSRSRSYSPRRY 160 170 180 >>NP_004584 (OMIM: 602719) transformer-2 protein homolog (288 aa) initn: 986 init1: 800 opt: 1163 Z-score: 593.2 bits: 117.6 E(85289): 2.7e-26 Smith-Waterman score: 1189; 65.2% identity (78.7% similar) in 305 aa overlap (1-282:1-288) 10 20 30 40 50 pF1KE0 MSDVEENNFEGRESRSQSKSPTGTPARVKSESRSGSRSPSRV-SKHSESHSRSRSKSRSR ::: :.:. ::::: :.: .. . :: .. .:: :. :..:.:.:::::.:::: NP_004 MSDSGEQNYGERESRSASRSGSAHGSG-KSARHTPARSRSKEDSRRSRSKSRSRSESRSR 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 SRRHSHRRYTRSRSHSHSHRRRSRSRSYTPEYRRRRSRSHSPMSNRRRHTGSRANPDPNT ::: :.:.::::::.:.:::: ::::::. .::::.:.::::::.::::.:.::::::: NP_004 SRRSSRRHYTRSRSRSRSHRR-SRSRSYSRDYRRRHSHSHSPMSTRRRHVGNRANPDPNC 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 CLGVFGLSLYTTERDLREVFSRYGPLSGVNVVYDQRTGRSRGFAFVYFERIDDSKEAMER :::::::::::::::::::::.:::.. :..::::.. ::::::::::: .::.::: :: NP_004 CLGVFGLSLYTTERDLREVFSKYGPIADVSIVYDQQSRRSRGFAFVYFENVDDAKEAKER 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 ANGMELDGRRIRVDYSITKRAHTPTPGIYMGRPTHSGGGGGGGGGGGGGGGGRRRDSYYD ::::::::::::::.::::: :::::::::::::. :..:::: ::: NP_004 ANGMELDGRRIRVDFSITKRPHTPTPGIYMGRPTY--------------GSSRRRD-YYD 180 190 200 210 220 240 250 260 270 pF1KE0 RGYDRGYDRYEDYD--YR------------------YRRRSPSPYYSR--YRSRSRSRSY :::::::: . :. :: :::::::::::: :::::::::: NP_004 RGYDRGYDDRDYYSRSYRGGGGGGGGWRAAQDRDQIYRRRSPSPYYSRGGYRSRSRSRSY 230 240 250 260 270 280 280 pF1KE0 SPRRY ::::: NP_004 SPRRY >>NP_001230808 (OMIM: 602719) transformer-2 protein homo (188 aa) initn: 871 init1: 658 opt: 838 Z-score: 437.7 bits: 88.3 E(85289): 1.2e-17 Smith-Waterman score: 864; 68.5% identity (77.3% similar) in 203 aa overlap (102-282:1-188) 80 90 100 110 120 130 pF1KE0 RSHSHSHRRRSRSRSYTPEYRRRRSRSHSPMSNRRRHTGSRANPDPNTCLGVFGLSLYTT ::.::::.:.::::::: :::::::::::: NP_001 MSTRRRHVGNRANPDPNCCLGVFGLSLYTT 10 20 30 140 150 160 170 180 190 pF1KE0 ERDLREVFSRYGPLSGVNVVYDQRTGRSRGFAFVYFERIDDSKEAMERANGMELDGRRIR :::::::::.:::.. :..::::.. ::::::::::: .::.::: :::::::::::::: NP_001 ERDLREVFSKYGPIADVSIVYDQQSRRSRGFAFVYFENVDDAKEAKERANGMELDGRRIR 40 50 60 70 80 90 200 210 220 230 240 250 pF1KE0 VDYSITKRAHTPTPGIYMGRPTHSGGGGGGGGGGGGGGGGRRRDSYYDRGYDRGYDRYED ::.::::: :::::::::::::. :..:::: ::::::::::: . NP_001 VDFSITKRPHTPTPGIYMGRPTY--------------GSSRRRD-YYDRGYDRGYDDRDY 100 110 120 130 260 270 280 pF1KE0 YD--YR------------------YRRRSPSPYYSR--YRSRSRSRSYSPRRY :. :: :::::::::::: ::::::::::::::: NP_001 YSRSYRGGGGGGGGWRAAQDRDQIYRRRSPSPYYSRGGYRSRSRSRSYSPRRY 140 150 160 170 180 >>XP_005247760 (OMIM: 602719) PREDICTED: transformer-2 p (188 aa) initn: 871 init1: 658 opt: 838 Z-score: 437.7 bits: 88.3 E(85289): 1.2e-17 Smith-Waterman score: 864; 68.5% identity (77.3% similar) in 203 aa overlap (102-282:1-188) 80 90 100 110 120 130 pF1KE0 RSHSHSHRRRSRSRSYTPEYRRRRSRSHSPMSNRRRHTGSRANPDPNTCLGVFGLSLYTT ::.::::.:.::::::: :::::::::::: XP_005 MSTRRRHVGNRANPDPNCCLGVFGLSLYTT 10 20 30 140 150 160 170 180 190 pF1KE0 ERDLREVFSRYGPLSGVNVVYDQRTGRSRGFAFVYFERIDDSKEAMERANGMELDGRRIR :::::::::.:::.. :..::::.. ::::::::::: .::.::: :::::::::::::: XP_005 ERDLREVFSKYGPIADVSIVYDQQSRRSRGFAFVYFENVDDAKEAKERANGMELDGRRIR 40 50 60 70 80 90 200 210 220 230 240 250 pF1KE0 VDYSITKRAHTPTPGIYMGRPTHSGGGGGGGGGGGGGGGGRRRDSYYDRGYDRGYDRYED ::.::::: :::::::::::::. :..:::: ::::::::::: . XP_005 VDFSITKRPHTPTPGIYMGRPTY--------------GSSRRRD-YYDRGYDRGYDDRDY 100 110 120 130 260 270 280 pF1KE0 YD--YR------------------YRRRSPSPYYSR--YRSRSRSRSYSPRRY :. :: :::::::::::: ::::::::::::::: XP_005 YSRSYRGGGGGGGGWRAAQDRDQIYRRRSPSPYYSRGGYRSRSRSRSYSPRRY 140 150 160 170 180 282 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 02:48:37 2016 done: Sat Nov 5 02:48:38 2016 Total Scan time: 6.670 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]