FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0696, 404 aa 1>>>pF1KE0696 404 - 404 aa - 404 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.0274+/-0.000852; mu= 8.8987+/- 0.051 mean_var=98.8841+/-20.055, 0's: 0 Z-trim(109.4): 82 B-trim: 436 in 1/50 Lambda= 0.128977 statistics sampled from 10744 (10829) to 10744 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.697), E-opt: 0.2 (0.333), width: 16 Scan time: 2.720 The best scores are: opt bits E(32554) CCDS7629.1 PLEKHA1 gene_id:59338|Hs108|chr10 ( 404) 2703 513.2 1.7e-145 CCDS55730.1 PLEKHA1 gene_id:59338|Hs108|chr10 ( 334) 2023 386.6 1.8e-107 CCDS81517.1 PLEKHA1 gene_id:59338|Hs108|chr10 ( 383) 2022 386.5 2.3e-107 CCDS75732.1 PLEKHA2 gene_id:59339|Hs108|chr8 ( 425) 883 174.5 1.6e-43 >>CCDS7629.1 PLEKHA1 gene_id:59338|Hs108|chr10 (404 aa) initn: 2703 init1: 2703 opt: 2703 Z-score: 2725.4 bits: 513.2 E(32554): 1.7e-145 Smith-Waterman score: 2703; 100.0% identity (100.0% similar) in 404 aa overlap (1-404:1-404) 10 20 30 40 50 60 pF1KE0 MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 LTYISKVSDATKLRPKAEFCFVMNAGMRKYFLQANDQQDLVEWVNVLNKAIKITVPKQSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 LTYISKVSDATKLRPKAEFCFVMNAGMRKYFLQANDQQDLVEWVNVLNKAIKITVPKQSD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 SQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 SQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 YFTPKPPQDSAVIKAGYCVKQGAVMKNWKRRYFQLDENTIGYFKSELEKEPLRVIPLKEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 YFTPKPPQDSAVIKAGYCVKQGAVMKNWKRRYFQLDENTIGYFKSELEKEPLRVIPLKEV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 HKVQECKQSDIMMRDNLFEIVTTSRTFYVQADSPEEMHSWIKAVSGAIVAQRGPGRSASS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 HKVQECKQSDIMMRDNLFEIVTTSRTFYVQADSPEEMHSWIKAVSGAIVAQRGPGRSASS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 EHPPGPSESKHAFRPTNAATATSHSTASRSNSLVSTFTMEKRGFYESLAKVKPGNFKVQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 EHPPGPSESKHAFRPTNAATATSHSTASRSNSLVSTFTMEKRGFYESLAKVKPGNFKVQT 310 320 330 340 350 360 370 380 390 400 pF1KE0 VSPREPASKVTEQALLRPQSKNGPQEKDCDLVDLDDASLPVSDV :::::::::::::::::::::::::::::::::::::::::::: CCDS76 VSPREPASKVTEQALLRPQSKNGPQEKDCDLVDLDDASLPVSDV 370 380 390 400 >>CCDS55730.1 PLEKHA1 gene_id:59338|Hs108|chr10 (334 aa) initn: 2022 init1: 2022 opt: 2023 Z-score: 2042.9 bits: 386.6 E(32554): 1.8e-107 Smith-Waterman score: 2023; 92.4% identity (94.6% similar) in 331 aa overlap (1-331:1-331) 10 20 30 40 50 60 pF1KE0 MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 LTYISKVSDATKLRPKAEFCFVMNAGMRKYFLQANDQQDLVEWVNVLNKAIKITVPKQSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 LTYISKVSDATKLRPKAEFCFVMNAGMRKYFLQANDQQDLVEWVNVLNKAIKITVPKQSD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 SQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 SQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 YFTPKPPQDSAVIKAGYCVKQGAVMKNWKRRYFQLDENTIGYFKSELEKEPLRVIPLKEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 YFTPKPPQDSAVIKAGYCVKQGAVMKNWKRRYFQLDENTIGYFKSELEKEPLRVIPLKEV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 HKVQECKQSDIMMRDNLFEIVTTSRTFYVQADSPEEMHSWIKAVSGAIVAQRGPGRSASS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 HKVQECKQSDIMMRDNLFEIVTTSRTFYVQADSPEEMHSWIKAVSGAIVAQRGPGRSASS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 EHPPGPSESKHAFRPTNAATATSHSTASRSNSLVSTFTMEKRGFYESLAKVKPGNFKVQT . . : :. : : ..:..: CCDS55 MRQARRLSNPCIQRYTSRAGECSTYVGSHANVPS 310 320 330 370 380 390 400 pF1KE0 VSPREPASKVTEQALLRPQSKNGPQEKDCDLVDLDDASLPVSDV >>CCDS81517.1 PLEKHA1 gene_id:59338|Hs108|chr10 (383 aa) initn: 2022 init1: 2022 opt: 2022 Z-score: 2041.0 bits: 386.5 E(32554): 2.3e-107 Smith-Waterman score: 2022; 100.0% identity (100.0% similar) in 300 aa overlap (1-300:1-300) 10 20 30 40 50 60 pF1KE0 MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 LTYISKVSDATKLRPKAEFCFVMNAGMRKYFLQANDQQDLVEWVNVLNKAIKITVPKQSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 LTYISKVSDATKLRPKAEFCFVMNAGMRKYFLQANDQQDLVEWVNVLNKAIKITVPKQSD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 SQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 SQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 YFTPKPPQDSAVIKAGYCVKQGAVMKNWKRRYFQLDENTIGYFKSELEKEPLRVIPLKEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 YFTPKPPQDSAVIKAGYCVKQGAVMKNWKRRYFQLDENTIGYFKSELEKEPLRVIPLKEV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 HKVQECKQSDIMMRDNLFEIVTTSRTFYVQADSPEEMHSWIKAVSGAIVAQRGPGRSASS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 HKVQECKQSDIMMRDNLFEIVTTSRTFYVQADSPEEMHSWIKAVSGAIVAQRGPGRSASS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 EHPPGPSESKHAFRPTNAATATSHSTASRSNSLVSTFTMEKRGFYESLAKVKPGNFKVQT CCDS81 MRQARRLSNPCIQRSIPPVLQNPNTLSVLPTQPPPPHIPQPLAATLWSQPLPWRSEDFTS 310 320 330 340 350 360 >>CCDS75732.1 PLEKHA2 gene_id:59339|Hs108|chr8 (425 aa) initn: 1119 init1: 382 opt: 883 Z-score: 894.8 bits: 174.5 E(32554): 1.6e-43 Smith-Waterman score: 1124; 47.0% identity (69.5% similar) in 430 aa overlap (1-404:1-425) 10 20 30 40 50 60 pF1KE0 MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIK ::::::::::::::::::.:::::::::::::::. . ..::::::::: :.. :::.. CCDS75 MPYVDRQNRICGFLDIEEHENSGKFLRRYFILDTQANCLLWYMDNPQNLAMGAGAVGALQ 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 LTYISKVSDAT-KLRPKAEFCFVMNAGMRKYFLQANDQQDLVEWVNVLNKAIKITVPKQS :::::::: :: : .::. ::::.:: ..::::::::.:. .::..::.: :::::: . CCDS75 LTYISKVSIATPKQKPKTPFCFVINALSQRYFLQANDQKDMKDWVEALNQASKITVPKGG 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 DSQPNSDNLSRHGE----CGKKQVSYRTDIVGGVPIITPTQKE--EVNECGESIDRNNLK ... :. . : ::.:.:.:.::: . :: ... . .: .: ... :. CCDS75 GLPMTTEVLKSLAAPPALEKKPQVAYKTEIIGGVVVHTPISQNGGDGQEGSEPGSHTILR 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE0 RSQSHLPYFTPKPPQDSAVIKAGYCVKQGAVMKNWKRRYFQLDENTIGYFKSELEKEPLR ::::..: . .::.::::::: : :.::::.: ::. :: ::: : ..:::: CCDS75 RSQSYIPTSGCRASTGPPLIKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDREPLR 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE0 VIPLKEVHKVQEC--KQSDIMMRDNLFEIVTTSRTFYVQADSPEEMHSWIKAVSGAIVAQ .: ::.: :..:: :..:..::::::::.:.::::::::::::.:::::: ...:. : CCDS75 TIFLKDVLKTHECLVKSGDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIKEIGAAVQAL 250 260 270 280 290 300 300 310 320 330 pF1KE0 R-GP-----GRSASSEHP------PGPSESKHAFRPTNAATATSHSTASRSNSLVSTFTM . : .:: : .: ::. :: . .. : ..: . CCDS75 KCHPRETSFSRSISLTRPGSSSLSSGPNSILCRGRPPLEEKKALCKAPSVASSWQPWTPV 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE0 EKRGFYESLAKVKPGNFKVQTV-SPRE---PASKVTEQALLRPQSK-NGPQEKDCDLVDL . : :.: . ::. . ... .:: : : .. .: .:. . :.:: . .: CCDS75 PQAG--EKL--LPPGDTSEDSLFTPRPGEGSAPGVLPSSRIRHRSEPQHPKEKPF-MFNL 370 380 390 400 410 400 pF1KE0 DDASLPVSDV :: .. .::: CCDS75 DDENIRTSDV 420 404 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 02:50:13 2016 done: Sat Nov 5 02:50:13 2016 Total Scan time: 2.720 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]