FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0705, 295 aa 1>>>pF1KE0705 295 - 295 aa - 295 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.4290+/-0.000377; mu= 12.9983+/- 0.024 mean_var=198.2682+/-43.660, 0's: 0 Z-trim(118.8): 196 B-trim: 1878 in 1/57 Lambda= 0.091085 statistics sampled from 31937 (32178) to 31937 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.727), E-opt: 0.2 (0.377), width: 16 Scan time: 7.600 The best scores are: opt bits E(85289) NP_001342 (OMIM: 601486) deleted in azoospermia-li ( 295) 2013 276.7 3.9e-74 NP_001177740 (OMIM: 601486) deleted in azoospermia ( 315) 2006 275.8 7.6e-74 NP_001005786 (OMIM: 400026,415000) deleted in azoo ( 366) 1077 153.8 4.7e-37 NP_065097 (OMIM: 400027,415000) deleted in azoospe ( 438) 1077 153.9 5.2e-37 NP_001005785 (OMIM: 400026,415000) deleted in azoo ( 534) 1077 154.0 5.8e-37 NP_065096 (OMIM: 400026,415000) deleted in azoospe ( 558) 1077 154.0 6e-37 XP_011529785 (OMIM: 400003,415000) PREDICTED: dele ( 529) 1070 153.1 1.1e-36 XP_011529784 (OMIM: 400003,415000) PREDICTED: dele ( 694) 1070 153.3 1.3e-36 NP_004072 (OMIM: 400003,415000) deleted in azoospe ( 744) 1070 153.3 1.3e-36 NP_149019 (OMIM: 606165) protein boule-like isofor ( 283) 400 64.7 2.4e-10 NP_001271291 (OMIM: 606165) protein boule-like iso ( 289) 400 64.7 2.4e-10 NP_932074 (OMIM: 606165) protein boule-like isofor ( 295) 400 64.7 2.5e-10 XP_006712778 (OMIM: 606165) PREDICTED: protein bou ( 291) 396 64.2 3.5e-10 XP_016860262 (OMIM: 606165) PREDICTED: protein bou ( 220) 375 61.2 2e-09 XP_011509996 (OMIM: 606165) PREDICTED: protein bou ( 305) 375 61.4 2.5e-09 XP_011509995 (OMIM: 606165) PREDICTED: protein bou ( 313) 375 61.4 2.5e-09 XP_011509994 (OMIM: 606165) PREDICTED: protein bou ( 317) 375 61.5 2.5e-09 NP_001271290 (OMIM: 606165) protein boule-like iso ( 339) 375 61.5 2.6e-09 >>NP_001342 (OMIM: 601486) deleted in azoospermia-like i (295 aa) initn: 2013 init1: 2013 opt: 2013 Z-score: 1452.0 bits: 276.7 E(85289): 3.9e-74 Smith-Waterman score: 2013; 100.0% identity (100.0% similar) in 295 aa overlap (1-295:1-295) 10 20 30 40 50 60 pF1KE0 MSTANPETPNSTISREASTQSSSAATSQGYILPEGKIMPNTVFVGGIDVRMDETEIRSFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSTANPETPNSTISREASTQSSSAATSQGYILPEGKIMPNTVFVGGIDVRMDETEIRSFF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 ARYGSVKEVKIITDRTGVSKGYGFVSFFNDVDVQKIVESQINFHGKKLKLGPAIRKQNLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ARYGSVKEVKIITDRTGVSKGYGFVSFFNDVDVQKIVESQINFHGKKLKLGPAIRKQNLC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 AYHVQPRPLVFNHPPPPQFQNVWTNPNTETYMQPTTTMNPITQYVQAYPTYPNSPVQVIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AYHVQPRPLVFNHPPPPQFQNVWTNPNTETYMQPTTTMNPITQYVQAYPTYPNSPVQVIT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 GYQLPVYNYQMPPQWPVGEQRSYVVPPAYSAVNYHCNEVDPGAEVVPNECSVHEATPPSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GYQLPVYNYQMPPQWPVGEQRSYVVPPAYSAVNYHCNEVDPGAEVVPNECSVHEATPPSG 190 200 210 220 230 240 250 260 270 280 290 pF1KE0 NGPQKKSVDRSIQTVVSCLFNPENRLRNSVVTQDDYFKDKRVHHFRRSRAMLKSV ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NGPQKKSVDRSIQTVVSCLFNPENRLRNSVVTQDDYFKDKRVHHFRRSRAMLKSV 250 260 270 280 290 >>NP_001177740 (OMIM: 601486) deleted in azoospermia-lik (315 aa) initn: 2006 init1: 2006 opt: 2006 Z-score: 1446.7 bits: 275.8 E(85289): 7.6e-74 Smith-Waterman score: 2006; 100.0% identity (100.0% similar) in 294 aa overlap (2-295:22-315) 10 20 30 40 pF1KE0 MSTANPETPNSTISREASTQSSSAATSQGYILPEGKIMPN ::::::::::::::::::::::::::::::::::::::: NP_001 MAAPSCGGDRKARLTPSLPHESTANPETPNSTISREASTQSSSAATSQGYILPEGKIMPN 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE0 TVFVGGIDVRMDETEIRSFFARYGSVKEVKIITDRTGVSKGYGFVSFFNDVDVQKIVESQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TVFVGGIDVRMDETEIRSFFARYGSVKEVKIITDRTGVSKGYGFVSFFNDVDVQKIVESQ 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE0 INFHGKKLKLGPAIRKQNLCAYHVQPRPLVFNHPPPPQFQNVWTNPNTETYMQPTTTMNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 INFHGKKLKLGPAIRKQNLCAYHVQPRPLVFNHPPPPQFQNVWTNPNTETYMQPTTTMNP 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE0 ITQYVQAYPTYPNSPVQVITGYQLPVYNYQMPPQWPVGEQRSYVVPPAYSAVNYHCNEVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ITQYVQAYPTYPNSPVQVITGYQLPVYNYQMPPQWPVGEQRSYVVPPAYSAVNYHCNEVD 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE0 PGAEVVPNECSVHEATPPSGNGPQKKSVDRSIQTVVSCLFNPENRLRNSVVTQDDYFKDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGAEVVPNECSVHEATPPSGNGPQKKSVDRSIQTVVSCLFNPENRLRNSVVTQDDYFKDK 250 260 270 280 290 300 290 pF1KE0 RVHHFRRSRAMLKSV ::::::::::::::: NP_001 RVHHFRRSRAMLKSV 310 >>NP_001005786 (OMIM: 400026,415000) deleted in azoosper (366 aa) initn: 1061 init1: 1061 opt: 1077 Z-score: 786.3 bits: 153.8 E(85289): 4.7e-37 Smith-Waterman score: 1077; 82.7% identity (90.8% similar) in 196 aa overlap (1-196:1-196) 10 20 30 40 50 60 pF1KE0 MSTANPETPNSTISREASTQSSSAATSQGYILPEGKIMPNTVFVGGIDVRMDETEIRSFF ::.::::::::::::::::::::::.:::..::::::.::::::::::.::::::: : : NP_001 MSAANPETPNSTISREASTQSSSAAASQGWVLPEGKIVPNTVFVGGIDARMDETEIGSCF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 ARYGSVKEVKIITDRTGVSKGYGFVSFFNDVDVQKIVESQINFHGKKLKLGPAIRKQNLC .::::::::::::.::::::::::::: ::::::::: :::.:::::::::::::::.:: NP_001 GRYGSVKEVKIITNRTGVSKGYGFVSFVNDVDVQKIVGSQIHFHGKKLKLGPAIRKQKLC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 AYHVQPRPLVFNHPPPPQFQNVWTNPNTETYMQPTTTMNPITQYVQAYPTYPNSPVQVIT : :::::::: : :::::::::: :::::::.:: : ::.::.:::: .::.:: :::: NP_001 ARHVQPRPLVVNPPPPPQFQNVWRNPNTETYLQPQITPNPVTQHVQAYSAYPHSPGQVIT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 GYQLPVYNYQMPPQWPVGEQRSYVVPPAYSAVNYHCNEVDPGAEVVPNECSVHEATPPSG : :: ::::: : .: NP_001 GCQLLVYNYQEYPTYPDSAFQVTTGYQLPVYNYQPFPAYPSSPFQVTAGYQLPVYNYQAF 190 200 210 220 230 240 >>NP_065097 (OMIM: 400027,415000) deleted in azoospermia (438 aa) initn: 1061 init1: 1061 opt: 1077 Z-score: 785.5 bits: 153.9 E(85289): 5.2e-37 Smith-Waterman score: 1077; 82.7% identity (90.8% similar) in 196 aa overlap (1-196:1-196) 10 20 30 40 50 60 pF1KE0 MSTANPETPNSTISREASTQSSSAATSQGYILPEGKIMPNTVFVGGIDVRMDETEIRSFF ::.::::::::::::::::::::::.:::..::::::.::::::::::.::::::: : : NP_065 MSAANPETPNSTISREASTQSSSAAASQGWVLPEGKIVPNTVFVGGIDARMDETEIGSCF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 ARYGSVKEVKIITDRTGVSKGYGFVSFFNDVDVQKIVESQINFHGKKLKLGPAIRKQNLC .::::::::::::.::::::::::::: ::::::::: :::.:::::::::::::::.:: NP_065 GRYGSVKEVKIITNRTGVSKGYGFVSFVNDVDVQKIVGSQIHFHGKKLKLGPAIRKQKLC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 AYHVQPRPLVFNHPPPPQFQNVWTNPNTETYMQPTTTMNPITQYVQAYPTYPNSPVQVIT : :::::::: : :::::::::: :::::::.:: : ::.::.:::: .::.:: :::: NP_065 ARHVQPRPLVVNPPPPPQFQNVWRNPNTETYLQPQITPNPVTQHVQAYSAYPHSPGQVIT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 GYQLPVYNYQMPPQWPVGEQRSYVVPPAYSAVNYHCNEVDPGAEVVPNECSVHEATPPSG : :: ::::: : .: NP_065 GCQLLVYNYQEYPTYPDSAFQVTTGYQLPVYNYQPFPAYPRSPFQVTAGYQLPVYNYQAF 190 200 210 220 230 240 >>NP_001005785 (OMIM: 400026,415000) deleted in azoosper (534 aa) initn: 1061 init1: 1061 opt: 1077 Z-score: 784.6 bits: 154.0 E(85289): 5.8e-37 Smith-Waterman score: 1077; 82.7% identity (90.8% similar) in 196 aa overlap (1-196:1-196) 10 20 30 40 50 60 pF1KE0 MSTANPETPNSTISREASTQSSSAATSQGYILPEGKIMPNTVFVGGIDVRMDETEIRSFF ::.::::::::::::::::::::::.:::..::::::.::::::::::.::::::: : : NP_001 MSAANPETPNSTISREASTQSSSAAASQGWVLPEGKIVPNTVFVGGIDARMDETEIGSCF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 ARYGSVKEVKIITDRTGVSKGYGFVSFFNDVDVQKIVESQINFHGKKLKLGPAIRKQNLC .::::::::::::.::::::::::::: ::::::::: :::.:::::::::::::::.:: NP_001 GRYGSVKEVKIITNRTGVSKGYGFVSFVNDVDVQKIVGSQIHFHGKKLKLGPAIRKQKLC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 AYHVQPRPLVFNHPPPPQFQNVWTNPNTETYMQPTTTMNPITQYVQAYPTYPNSPVQVIT : :::::::: : :::::::::: :::::::.:: : ::.::.:::: .::.:: :::: NP_001 ARHVQPRPLVVNPPPPPQFQNVWRNPNTETYLQPQITPNPVTQHVQAYSAYPHSPGQVIT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 GYQLPVYNYQMPPQWPVGEQRSYVVPPAYSAVNYHCNEVDPGAEVVPNECSVHEATPPSG : :: ::::: : .: NP_001 GCQLLVYNYQEYPTYPDSAFQVTTGYQLPVYNYQPFPAYPRSPFQVTAGYQLPVYNYQAF 190 200 210 220 230 240 >>NP_065096 (OMIM: 400026,415000) deleted in azoospermia (558 aa) initn: 1061 init1: 1061 opt: 1077 Z-score: 784.4 bits: 154.0 E(85289): 6e-37 Smith-Waterman score: 1077; 82.7% identity (90.8% similar) in 196 aa overlap (1-196:1-196) 10 20 30 40 50 60 pF1KE0 MSTANPETPNSTISREASTQSSSAATSQGYILPEGKIMPNTVFVGGIDVRMDETEIRSFF ::.::::::::::::::::::::::.:::..::::::.::::::::::.::::::: : : NP_065 MSAANPETPNSTISREASTQSSSAAASQGWVLPEGKIVPNTVFVGGIDARMDETEIGSCF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 ARYGSVKEVKIITDRTGVSKGYGFVSFFNDVDVQKIVESQINFHGKKLKLGPAIRKQNLC .::::::::::::.::::::::::::: ::::::::: :::.:::::::::::::::.:: NP_065 GRYGSVKEVKIITNRTGVSKGYGFVSFVNDVDVQKIVGSQIHFHGKKLKLGPAIRKQKLC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 AYHVQPRPLVFNHPPPPQFQNVWTNPNTETYMQPTTTMNPITQYVQAYPTYPNSPVQVIT : :::::::: : :::::::::: :::::::.:: : ::.::.:::: .::.:: :::: NP_065 ARHVQPRPLVVNPPPPPQFQNVWRNPNTETYLQPQITPNPVTQHVQAYSAYPHSPGQVIT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 GYQLPVYNYQMPPQWPVGEQRSYVVPPAYSAVNYHCNEVDPGAEVVPNECSVHEATPPSG : :: ::::: : .: NP_065 GCQLLVYNYQEYPTYPDSAFQVTTGYQLPVYNYQPFPAYPRSPFQVTAGYQLPVYNYQAF 190 200 210 220 230 240 >>XP_011529785 (OMIM: 400003,415000) PREDICTED: deleted (529 aa) initn: 1054 init1: 1054 opt: 1070 Z-score: 779.6 bits: 153.1 E(85289): 1.1e-36 Smith-Waterman score: 1070; 82.6% identity (90.8% similar) in 195 aa overlap (2-196:117-311) 10 20 30 pF1KE0 MSTANPETPNSTISREASTQSSSAATSQGYI :.::::::::::::::::::::::.:::.. XP_011 PQFQNVWRNPNTETYLQPQITPNPVTQHVQSAANPETPNSTISREASTQSSSAAASQGWV 90 100 110 120 130 140 40 50 60 70 80 90 pF1KE0 LPEGKIMPNTVFVGGIDVRMDETEIRSFFARYGSVKEVKIITDRTGVSKGYGFVSFFNDV ::::::.::::::::::.::::::: : :.::::::::::::.::::::::::::: ::: XP_011 LPEGKIVPNTVFVGGIDARMDETEIGSCFGRYGSVKEVKIITNRTGVSKGYGFVSFVNDV 150 160 170 180 190 200 100 110 120 130 140 150 pF1KE0 DVQKIVESQINFHGKKLKLGPAIRKQNLCAYHVQPRPLVFNHPPPPQFQNVWTNPNTETY :::::: :::.:::::::::::::::.::: :::::::: : :::::::::: ::::::: XP_011 DVQKIVGSQIHFHGKKLKLGPAIRKQKLCARHVQPRPLVVNPPPPPQFQNVWRNPNTETY 210 220 230 240 250 260 160 170 180 190 200 210 pF1KE0 MQPTTTMNPITQYVQAYPTYPNSPVQVITGYQLPVYNYQMPPQWPVGEQRSYVVPPAYSA .:: : ::.::.:::: .::.:: ::::: :: ::::: : .: XP_011 LQPQITPNPVTQHVQAYSAYPHSPGQVITGCQLLVYNYQEYPTYPDSAFQVTTGYQLPVY 270 280 290 300 310 320 220 230 240 250 260 270 pF1KE0 VNYHCNEVDPGAEVVPNECSVHEATPPSGNGPQKKSVDRSIQTVVSCLFNPENRLRNSVV XP_011 NYQPFPAYPRSPFQVTAGYQLPVYNYQAFPAYPNSPFQVATGYQFPVYNYQPFPAYPSSP 330 340 350 360 370 380 >-- initn: 664 init1: 664 opt: 664 Z-score: 491.3 bits: 99.7 E(85289): 1.3e-20 Smith-Waterman score: 664; 84.5% identity (90.5% similar) in 116 aa overlap (51-166:1-116) 30 40 50 60 70 80 pF1KE0 SSSAATSQGYILPEGKIMPNTVFVGGIDVRMDETEIRSFFARYGSVKEVKIITDRTGVSK :::::: : :.::::::::::::.:::::: XP_011 MDETEIGSCFGRYGSVKEVKIITNRTGVSK 10 20 30 90 100 110 120 130 140 pF1KE0 GYGFVSFFNDVDVQKIVESQINFHGKKLKLGPAIRKQNLCAYHVQPRPLVFNHPPPPQFQ ::::::: ::::::::: :::.:::::::::::::::.::: :::::::: : ::::::: XP_011 GYGFVSFVNDVDVQKIVGSQIHFHGKKLKLGPAIRKQKLCARHVQPRPLVVNPPPPPQFQ 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE0 NVWTNPNTETYMQPTTTMNPITQYVQAYPTYPNSPVQVITGYQLPVYNYQMPPQWPVGEQ ::: :::::::.:: : ::.::.:: XP_011 NVWRNPNTETYLQPQITPNPVTQHVQSAANPETPNSTISREASTQSSSAAASQGWVLPEG 100 110 120 130 140 150 >>XP_011529784 (OMIM: 400003,415000) PREDICTED: deleted (694 aa) initn: 1589 init1: 1054 opt: 1070 Z-score: 778.4 bits: 153.3 E(85289): 1.3e-36 Smith-Waterman score: 1070; 82.6% identity (90.8% similar) in 195 aa overlap (2-196:282-476) 10 20 30 pF1KE0 MSTANPETPNSTISREASTQSSSAATSQGYI :.::::::::::::::::::::::.:::.. XP_011 PQFQNVWRNPNTETYLQPQITPNPVTQHVQSAANPETPNSTISREASTQSSSAAASQGWV 260 270 280 290 300 310 40 50 60 70 80 90 pF1KE0 LPEGKIMPNTVFVGGIDVRMDETEIRSFFARYGSVKEVKIITDRTGVSKGYGFVSFFNDV ::::::.::::::::::.::::::: : :.::::::::::::.::::::::::::: ::: XP_011 LPEGKIVPNTVFVGGIDARMDETEIGSCFGRYGSVKEVKIITNRTGVSKGYGFVSFVNDV 320 330 340 350 360 370 100 110 120 130 140 150 pF1KE0 DVQKIVESQINFHGKKLKLGPAIRKQNLCAYHVQPRPLVFNHPPPPQFQNVWTNPNTETY :::::: :::.:::::::::::::::.::: :::::::: : :::::::::: ::::::: XP_011 DVQKIVGSQIHFHGKKLKLGPAIRKQKLCARHVQPRPLVVNPPPPPQFQNVWRNPNTETY 380 390 400 410 420 430 160 170 180 190 200 210 pF1KE0 MQPTTTMNPITQYVQAYPTYPNSPVQVITGYQLPVYNYQMPPQWPVGEQRSYVVPPAYSA .:: : ::.::.:::: .::.:: ::::: :: ::::: : .: XP_011 LQPQITPNPVTQHVQAYSAYPHSPGQVITGCQLLVYNYQEYPTYPDSAFQVTTGYQLPVY 440 450 460 470 480 490 220 230 240 250 260 270 pF1KE0 VNYHCNEVDPGAEVVPNECSVHEATPPSGNGPQKKSVDRSIQTVVSCLFNPENRLRNSVV XP_011 NYQPFPAYPRSPFQVTAGYQLPVYNYQAFPAYPNSPFQVATGYQFPVYNYQPFPAYPSSP 500 510 520 530 540 550 >-- initn: 942 init1: 942 opt: 942 Z-score: 687.5 bits: 136.4 E(85289): 1.5e-31 Smith-Waterman score: 942; 85.5% identity (93.3% similar) in 165 aa overlap (2-166:117-281) 10 20 30 pF1KE0 MSTANPETPNSTISREASTQSSSAATSQGYI :.::::::::::::::::::::::.:::.. XP_011 PQFQNVWRNPNTETYLQPQITPNPVTQHVQSAANPETPNSTISREASTQSSSAAASQGWV 90 100 110 120 130 140 40 50 60 70 80 90 pF1KE0 LPEGKIMPNTVFVGGIDVRMDETEIRSFFARYGSVKEVKIITDRTGVSKGYGFVSFFNDV ::::::.::::::::::.::::::: : :.::::::::::::.::::::::::::: ::: XP_011 LPEGKIVPNTVFVGGIDARMDETEIGSCFGRYGSVKEVKIITNRTGVSKGYGFVSFVNDV 150 160 170 180 190 200 100 110 120 130 140 150 pF1KE0 DVQKIVESQINFHGKKLKLGPAIRKQNLCAYHVQPRPLVFNHPPPPQFQNVWTNPNTETY :::::: :::.:::::::::::::::.::: :::::::: : :::::::::: ::::::: XP_011 DVQKIVGSQIHFHGKKLKLGPAIRKQKLCARHVQPRPLVVNPPPPPQFQNVWRNPNTETY 210 220 230 240 250 260 160 170 180 190 200 210 pF1KE0 MQPTTTMNPITQYVQAYPTYPNSPVQVITGYQLPVYNYQMPPQWPVGEQRSYVVPPAYSA .:: : ::.::.:: XP_011 LQPQITPNPVTQHVQSAANPETPNSTISREASTQSSSAAASQGWVLPEGKIVPNTVFVGG 270 280 290 300 310 320 >-- initn: 664 init1: 664 opt: 664 Z-score: 490.1 bits: 99.9 E(85289): 1.5e-20 Smith-Waterman score: 664; 84.5% identity (90.5% similar) in 116 aa overlap (51-166:1-116) 30 40 50 60 70 80 pF1KE0 SSSAATSQGYILPEGKIMPNTVFVGGIDVRMDETEIRSFFARYGSVKEVKIITDRTGVSK :::::: : :.::::::::::::.:::::: XP_011 MDETEIGSCFGRYGSVKEVKIITNRTGVSK 10 20 30 90 100 110 120 130 140 pF1KE0 GYGFVSFFNDVDVQKIVESQINFHGKKLKLGPAIRKQNLCAYHVQPRPLVFNHPPPPQFQ ::::::: ::::::::: :::.:::::::::::::::.::: :::::::: : ::::::: XP_011 GYGFVSFVNDVDVQKIVGSQIHFHGKKLKLGPAIRKQKLCARHVQPRPLVVNPPPPPQFQ 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE0 NVWTNPNTETYMQPTTTMNPITQYVQAYPTYPNSPVQVITGYQLPVYNYQMPPQWPVGEQ ::: :::::::.:: : ::.::.:: XP_011 NVWRNPNTETYLQPQITPNPVTQHVQSAANPETPNSTISREASTQSSSAAASQGWVLPEG 100 110 120 130 140 150 >>NP_004072 (OMIM: 400003,415000) deleted in azoospermia (744 aa) initn: 1874 init1: 1054 opt: 1070 Z-score: 778.1 bits: 153.3 E(85289): 1.3e-36 Smith-Waterman score: 1070; 82.6% identity (90.8% similar) in 195 aa overlap (2-196:332-526) 10 20 30 pF1KE0 MSTANPETPNSTISREASTQSSSAATSQGYI :.::::::::::::::::::::::.:::.. NP_004 PQFQNVWRNPNTETYLQPQITPNPVTQHVQSAANPETPNSTISREASTQSSSAAASQGWV 310 320 330 340 350 360 40 50 60 70 80 90 pF1KE0 LPEGKIMPNTVFVGGIDVRMDETEIRSFFARYGSVKEVKIITDRTGVSKGYGFVSFFNDV ::::::.::::::::::.::::::: : :.::::::::::::.::::::::::::: ::: NP_004 LPEGKIVPNTVFVGGIDARMDETEIGSCFGRYGSVKEVKIITNRTGVSKGYGFVSFVNDV 370 380 390 400 410 420 100 110 120 130 140 150 pF1KE0 DVQKIVESQINFHGKKLKLGPAIRKQNLCAYHVQPRPLVFNHPPPPQFQNVWTNPNTETY :::::: :::.:::::::::::::::.::: :::::::: : :::::::::: ::::::: NP_004 DVQKIVGSQIHFHGKKLKLGPAIRKQKLCARHVQPRPLVVNPPPPPQFQNVWRNPNTETY 430 440 450 460 470 480 160 170 180 190 200 210 pF1KE0 MQPTTTMNPITQYVQAYPTYPNSPVQVITGYQLPVYNYQMPPQWPVGEQRSYVVPPAYSA .:: : ::.::.:::: .::.:: ::::: :: ::::: : .: NP_004 LQPQITPNPVTQHVQAYSAYPHSPGQVITGCQLLVYNYQEYPTYPDSAFQVTTGYQLPVY 490 500 510 520 530 540 220 230 240 250 260 270 pF1KE0 VNYHCNEVDPGAEVVPNECSVHEATPPSGNGPQKKSVDRSIQTVVSCLFNPENRLRNSVV NP_004 NYQPFPAYPRSPFQVTAGYQLPVYNYQAFPAYPNSPFQVATGYQFPVYNYQPFPAYPSSP 550 560 570 580 590 600 >-- initn: 991 init1: 950 opt: 970 Z-score: 707.1 bits: 140.2 E(85289): 1.2e-32 Smith-Waterman score: 970; 82.6% identity (90.4% similar) in 178 aa overlap (1-176:1-178) 10 20 30 40 50 60 pF1KE0 MSTANPETPNSTISREASTQSSSAATSQGYILPEGKIMPNTVFVGGIDVRMDETEIRSFF ::.::::::::::::::::::::::.:::..::::::.::::::::::.::::::: : : NP_004 MSAANPETPNSTISREASTQSSSAAASQGWVLPEGKIVPNTVFVGGIDARMDETEIGSCF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 ARYGSVKEVKIITDRTGVSKGYGFVSFFNDVDVQKIVESQINFHGKKLKLGPAIRKQNLC .::::::::::::.::::::::::::: ::::::::: :::.:::::::::::::::.:: NP_004 GRYGSVKEVKIITNRTGVSKGYGFVSFVNDVDVQKIVGSQIHFHGKKLKLGPAIRKQKLC 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 AYHVQPRPLVFNHPPPPQFQNVWTNPNTETYMQPTTTMNPITQYVQ--AYPTYPNSPVQV : :::::::: : :::::::::: :::::::.:: : ::.::.:: : : ::: . NP_004 ARHVQPRPLVVNPPPPPQFQNVWRNPNTETYLQPQITPNPVTQHVQSAANPETPNSTISR 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE0 ITGYQLPVYNYQMPPQWPVGEQRSYVVPPAYSAVNYHCNEVDPGAEVVPNECSVHEATPP NP_004 EASTQSSSAAASQGWVLPEGKIVPNTVFVGGIDARMDETEIGSCFGRYGSVKEVKIITNR 190 200 210 220 230 240 >-- initn: 872 init1: 872 opt: 872 Z-score: 637.5 bits: 127.3 E(85289): 9.1e-29 Smith-Waterman score: 872; 85.0% identity (92.8% similar) in 153 aa overlap (14-166:179-331) 10 20 30 40 pF1KE0 MSTANPETPNSTISREASTQSSSAATSQGYILPEGKIMPNTVF ::::::::::::.:::..::::::.::::: NP_004 ETYLQPQITPNPVTQHVQSAANPETPNSTISREASTQSSSAAASQGWVLPEGKIVPNTVF 150 160 170 180 190 200 50 60 70 80 90 100 pF1KE0 VGGIDVRMDETEIRSFFARYGSVKEVKIITDRTGVSKGYGFVSFFNDVDVQKIVESQINF :::::.::::::: : :.::::::::::::.::::::::::::: ::::::::: :::.: NP_004 VGGIDARMDETEIGSCFGRYGSVKEVKIITNRTGVSKGYGFVSFVNDVDVQKIVGSQIHF 210 220 230 240 250 260 110 120 130 140 150 160 pF1KE0 HGKKLKLGPAIRKQNLCAYHVQPRPLVFNHPPPPQFQNVWTNPNTETYMQPTTTMNPITQ ::::::::::::::.::: :::::::: : :::::::::: :::::::.:: : ::.:: NP_004 HGKKLKLGPAIRKQKLCARHVQPRPLVVNPPPPPQFQNVWRNPNTETYLQPQITPNPVTQ 270 280 290 300 310 320 170 180 190 200 210 220 pF1KE0 YVQAYPTYPNSPVQVITGYQLPVYNYQMPPQWPVGEQRSYVVPPAYSAVNYHCNEVDPGA .:: NP_004 HVQSAANPETPNSTISREASTQSSSAAASQGWVLPEGKIVPNTVFVGGIDARMDETEIGS 330 340 350 360 370 380 >>NP_149019 (OMIM: 606165) protein boule-like isoform 2 (283 aa) initn: 319 init1: 288 opt: 400 Z-score: 306.7 bits: 64.7 E(85289): 2.4e-10 Smith-Waterman score: 416; 33.6% identity (59.3% similar) in 268 aa overlap (35-285:28-283) 10 20 30 40 50 60 pF1KE0 NPETPNSTISREASTQSSSAATSQGYILPEGKIMPNTVFVGGIDVRMDETEIRSFFARYG : ..:: .:::::: . .:...:.::..:: NP_149 MQTDSLSPSPNPVSPVPLNNPTSAPRYGTVIPNRIFVGGIDFKTNESDLRKFFSQYG 10 20 30 40 50 70 80 90 100 110 120 pF1KE0 SVKEVKIITDRTGVSKGYGFVSFFNDVDVQKIVES--QINFHGKKLKLGPAIRKQNLCAY :::::::..::.:::::::::.: .. :.:::.. ..:.. :::..:::::::.. NP_149 SVKEVKIVNDRAGVSKGYGFVTFETQEDAQKILQEAEKLNYKDKKLNIGPAIRKQQVGI- 60 70 80 90 100 110 130 140 150 160 170 pF1KE0 HVQPRPLVFNHPPPPQFQNVWTNPNTETYMQPTTTMN-P-ITQYVQAYPTYP--NSPVQV :: .. : . . .. :: . .. .. : .:. .:. .:::.: NP_149 ---PRSSIM--PAAGTMYLTTSTGYPYTYHNGVAYFHTPEVTSVPPPWPSRSVCSSPVMV 120 130 140 150 160 170 180 190 200 210 220 pF1KE0 ITG-YQLPVYNYQ-----MPPQWP--VGEQRSYVVPPAY---SAVNYHCNEVDPGAEVVP :: :.:.:: .: :: : . . .: : : : :. :. . :: NP_149 AQPIYQQPAYHYQATTQYLPGQWQWSVPQPSASSAPFLYLQPSEVIYQPVEIAQDGGCVP 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE0 NECSVHEATPPSGNGPQKKSVDRSIQTVVSCLFNPENRLRNSVVTQDDYFKDKRVHHFRR :. :.. : : . :...:.. .. : . : : . .: :. NP_149 PPLSLMETSVPE---PYS---DHGVQATYHQVYAPSAITMPAPVMQPEPIKTVWSIHY 240 250 260 270 280 290 pF1KE0 SRAMLKSV 295 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 02:52:35 2016 done: Sat Nov 5 02:52:36 2016 Total Scan time: 7.600 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]