FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0734, 422 aa 1>>>pF1KE0734 422 - 422 aa - 422 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.2961+/-0.000535; mu= -12.6903+/- 0.032 mean_var=631.2748+/-150.644, 0's: 0 Z-trim(114.9): 126 B-trim: 1122 in 1/53 Lambda= 0.051046 statistics sampled from 24920 (25031) to 24920 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.66), E-opt: 0.2 (0.293), width: 16 Scan time: 9.020 The best scores are: opt bits E(85289) NP_071331 (OMIM: 606274) casein kinase I isoform g ( 422) 2863 226.8 8.1e-59 NP_001316535 (OMIM: 606274) casein kinase I isofor ( 422) 2863 226.8 8.1e-59 NP_001316536 (OMIM: 606274) casein kinase I isofor ( 438) 2752 218.6 2.4e-56 NP_001316534 (OMIM: 606274) casein kinase I isofor ( 475) 2531 202.4 2e-51 XP_005271953 (OMIM: 604253) PREDICTED: casein kina ( 416) 2346 188.7 2.3e-47 XP_016864559 (OMIM: 604253) PREDICTED: casein kina ( 415) 2328 187.4 5.8e-47 NP_001257501 (OMIM: 604253) casein kinase I isofor ( 424) 2314 186.4 1.2e-46 XP_005271952 (OMIM: 604253) PREDICTED: casein kina ( 424) 2314 186.4 1.2e-46 XP_016864558 (OMIM: 604253) PREDICTED: casein kina ( 424) 2314 186.4 1.2e-46 NP_001026982 (OMIM: 604253) casein kinase I isofor ( 423) 2296 185.0 3e-46 NP_001310 (OMIM: 602214) casein kinase I isoform g ( 415) 2269 183.0 1.2e-45 XP_016864556 (OMIM: 604253) PREDICTED: casein kina ( 441) 2104 170.9 5.6e-42 XP_016864557 (OMIM: 604253) PREDICTED: casein kina ( 440) 2086 169.6 1.4e-41 XP_016864553 (OMIM: 604253) PREDICTED: casein kina ( 449) 2072 168.6 2.9e-41 XP_005271948 (OMIM: 604253) PREDICTED: casein kina ( 456) 2064 168.0 4.4e-41 XP_016864554 (OMIM: 604253) PREDICTED: casein kina ( 448) 2054 167.3 7.2e-41 XP_016864555 (OMIM: 604253) PREDICTED: casein kina ( 448) 2054 167.3 7.2e-41 XP_005271951 (OMIM: 604253) PREDICTED: casein kina ( 447) 2046 166.7 1.1e-40 NP_004375 (OMIM: 604253) casein kinase I isoform g ( 447) 2046 166.7 1.1e-40 XP_005271949 (OMIM: 604253) PREDICTED: casein kina ( 455) 2046 166.7 1.1e-40 NP_001038188 (OMIM: 604253) casein kinase I isofor ( 455) 2046 166.7 1.1e-40 XP_016881787 (OMIM: 602214) PREDICTED: casein kina ( 367) 2041 166.2 1.3e-40 XP_005259557 (OMIM: 602214) PREDICTED: casein kina ( 440) 2008 163.9 7.5e-40 NP_001257502 (OMIM: 604253) casein kinase I isofor ( 348) 1952 159.6 1.1e-38 XP_005259556 (OMIM: 602214) PREDICTED: casein kina ( 445) 1839 151.4 4.2e-36 XP_016881786 (OMIM: 602214) PREDICTED: casein kina ( 445) 1839 151.4 4.2e-36 XP_005259555 (OMIM: 602214) PREDICTED: casein kina ( 445) 1839 151.4 4.2e-36 XP_016864552 (OMIM: 604253) PREDICTED: casein kina ( 473) 1822 150.2 1e-35 XP_016864546 (OMIM: 604253) PREDICTED: casein kina ( 481) 1822 150.2 1e-35 XP_016864547 (OMIM: 604253) PREDICTED: casein kina ( 481) 1822 150.2 1e-35 XP_016864548 (OMIM: 604253) PREDICTED: casein kina ( 481) 1822 150.2 1e-35 XP_016864549 (OMIM: 604253) PREDICTED: casein kina ( 481) 1822 150.2 1e-35 XP_016864551 (OMIM: 604253) PREDICTED: casein kina ( 480) 1804 148.9 2.6e-35 XP_016864550 (OMIM: 604253) PREDICTED: casein kina ( 480) 1804 148.9 2.6e-35 XP_005259558 (OMIM: 602214) PREDICTED: casein kina ( 392) 1780 147.0 8e-35 NP_001257503 (OMIM: 604253) casein kinase I isofor ( 311) 1721 142.5 1.4e-33 NP_001885 (OMIM: 600863) casein kinase I isoform e ( 416) 1202 104.5 5.4e-22 NP_689407 (OMIM: 600863) casein kinase I isoform e ( 416) 1202 104.5 5.4e-22 NP_620693 (OMIM: 600864,615224) casein kinase I is ( 409) 1190 103.6 9.8e-22 NP_001884 (OMIM: 600864,615224) casein kinase I is ( 415) 1190 103.6 9.9e-22 XP_005256394 (OMIM: 600864,615224) PREDICTED: case ( 427) 1190 103.6 1e-21 XP_005256393 (OMIM: 600864,615224) PREDICTED: case ( 450) 1190 103.6 1e-21 NP_001258670 (OMIM: 600505) casein kinase I isofor ( 325) 1112 97.7 4.6e-20 NP_001883 (OMIM: 600505) casein kinase I isoform a ( 337) 1112 97.7 4.7e-20 XP_016879688 (OMIM: 600864,615224) PREDICTED: case ( 393) 1003 89.8 1.3e-17 NP_001258671 (OMIM: 600505) casein kinase I isofor ( 276) 618 61.2 3.7e-09 NP_001020276 (OMIM: 600505) casein kinase I isofor ( 365) 618 61.4 4.4e-09 NP_775771 (OMIM: 604432,611695) tau-tubulin kinase (1244) 537 56.2 5.6e-07 XP_006720466 (OMIM: 604432,611695) PREDICTED: tau- (1175) 445 49.3 5.9e-05 XP_005254230 (OMIM: 604432,611695) PREDICTED: tau- (1175) 445 49.3 5.9e-05 >>NP_071331 (OMIM: 606274) casein kinase I isoform gamma (422 aa) initn: 2863 init1: 2863 opt: 2863 Z-score: 1176.9 bits: 226.8 E(85289): 8.1e-59 Smith-Waterman score: 2863; 100.0% identity (100.0% similar) in 422 aa overlap (1-422:1-422) 10 20 30 40 50 60 pF1KE0 MDHPSREKDERQRTTKPMAQRSAHCSRPSGSSSSSGVLMVGPNFRVGKKIGCGNFGELRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 MDHPSREKDERQRTTKPMAQRSAHCSRPSGSSSSSGVLMVGPNFRVGKKIGCGNFGELRL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 GKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGEGLPQVYYFGPCGKYNAMVLEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 GKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGEGLPQVYYFGPCGKYNAMVLEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 LGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 LGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 HVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 HVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 FMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEALCENFPEEMATYLRYVRRLDFFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 FMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEALCENFPEEMATYLRYVRRLDFFE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 KPDYEYLRTLFTDLFEKKGYTFDYAYDWVGRPIPTPVGSVHVDSGASAITRESHTHRDRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 KPDYEYLRTLFTDLFEKKGYTFDYAYDWVGRPIPTPVGSVHVDSGASAITRESHTHRDRP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 SQQQPLRNQVVSSTNGELNVDDPTGAHSNAPITAHAEVEVVEEAKCCCFFKRKRKKTAQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 SQQQPLRNQVVSSTNGELNVDDPTGAHSNAPITAHAEVEVVEEAKCCCFFKRKRKKTAQR 370 380 390 400 410 420 pF1KE0 HK :: NP_071 HK >>NP_001316535 (OMIM: 606274) casein kinase I isoform ga (422 aa) initn: 2863 init1: 2863 opt: 2863 Z-score: 1176.9 bits: 226.8 E(85289): 8.1e-59 Smith-Waterman score: 2863; 100.0% identity (100.0% similar) in 422 aa overlap (1-422:1-422) 10 20 30 40 50 60 pF1KE0 MDHPSREKDERQRTTKPMAQRSAHCSRPSGSSSSSGVLMVGPNFRVGKKIGCGNFGELRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDHPSREKDERQRTTKPMAQRSAHCSRPSGSSSSSGVLMVGPNFRVGKKIGCGNFGELRL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 GKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGEGLPQVYYFGPCGKYNAMVLEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGEGLPQVYYFGPCGKYNAMVLEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 LGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 HVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 FMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEALCENFPEEMATYLRYVRRLDFFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEALCENFPEEMATYLRYVRRLDFFE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 KPDYEYLRTLFTDLFEKKGYTFDYAYDWVGRPIPTPVGSVHVDSGASAITRESHTHRDRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KPDYEYLRTLFTDLFEKKGYTFDYAYDWVGRPIPTPVGSVHVDSGASAITRESHTHRDRP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 SQQQPLRNQVVSSTNGELNVDDPTGAHSNAPITAHAEVEVVEEAKCCCFFKRKRKKTAQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SQQQPLRNQVVSSTNGELNVDDPTGAHSNAPITAHAEVEVVEEAKCCCFFKRKRKKTAQR 370 380 390 400 410 420 pF1KE0 HK :: NP_001 HK >>NP_001316536 (OMIM: 606274) casein kinase I isoform ga (438 aa) initn: 2752 init1: 2752 opt: 2752 Z-score: 1132.6 bits: 218.6 E(85289): 2.4e-56 Smith-Waterman score: 2752; 99.3% identity (99.3% similar) in 411 aa overlap (1-411:1-411) 10 20 30 40 50 60 pF1KE0 MDHPSREKDERQRTTKPMAQRSAHCSRPSGSSSSSGVLMVGPNFRVGKKIGCGNFGELRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDHPSREKDERQRTTKPMAQRSAHCSRPSGSSSSSGVLMVGPNFRVGKKIGCGNFGELRL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 GKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGEGLPQVYYFGPCGKYNAMVLEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGEGLPQVYYFGPCGKYNAMVLEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 LGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 HVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 FMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEALCENFPEEMATYLRYVRRLDFFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEALCENFPEEMATYLRYVRRLDFFE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 KPDYEYLRTLFTDLFEKKGYTFDYAYDWVGRPIPTPVGSVHVDSGASAITRESHTHRDRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KPDYEYLRTLFTDLFEKKGYTFDYAYDWVGRPIPTPVGSVHVDSGASAITRESHTHRDRP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 SQQQPLRNQVVSSTNGELNVDDPTGAHSNAPITAHAEVEVVEEAKCCCFFKRKRKKTAQR :::::::::::::::::::::::::::::::::::::::::::::: : : NP_001 SQQQPLRNQVVSSTNGELNVDDPTGAHSNAPITAHAEVEVVEEAKCIMFHKPWHWSQSSA 370 380 390 400 410 420 pF1KE0 HK NP_001 VKMKFVVFLNMNVNFKCI 430 >>NP_001316534 (OMIM: 606274) casein kinase I isoform ga (475 aa) initn: 2757 init1: 2518 opt: 2531 Z-score: 1044.3 bits: 202.4 E(85289): 2e-51 Smith-Waterman score: 2668; 91.1% identity (91.1% similar) in 448 aa overlap (1-411:1-448) 10 20 30 40 50 60 pF1KE0 MDHPSREKDERQRTTKPMAQRSAHCSRPSGSSSSSGVLMVGPNFRVGKKIGCGNFGELRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDHPSREKDERQRTTKPMAQRSAHCSRPSGSSSSSGVLMVGPNFRVGKKIGCGNFGELRL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 GKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGEGLPQVYYFGPCGKYNAMVLEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGEGLPQVYYFGPCGKYNAMVLEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 LGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 HVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 FMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEALCENFPEEMATYLRYVRRLDFFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEALCENFPEEMATYLRYVRRLDFFE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 KPDYEYLRTLFTDLFEKKGYTFDYAYDWVGRPIPTPVGSVHVDSGASAITRESHTHRDRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KPDYEYLRTLFTDLFEKKGYTFDYAYDWVGRPIPTPVGSVHVDSGASAITRESHTHRDRP 310 320 330 340 350 360 370 380 pF1KE0 SQQQPLRNQ-------------------------------------VVSSTNGELNVDDP ::::::::: :::::::::::::: NP_001 SQQQPLRNQNVSSERRGEWEIQPSRQTNTSYLTSHLAADRHGGSVQVVSSTNGELNVDDP 370 380 390 400 410 420 390 400 410 420 pF1KE0 TGAHSNAPITAHAEVEVVEEAKCCCFFKRKRKKTAQRHK ::::::::::::::::::::::: : : NP_001 TGAHSNAPITAHAEVEVVEEAKCIMFHKPWHWSQSSAVKMKFVVFLNMNVNFKCI 430 440 450 460 470 >>XP_005271953 (OMIM: 604253) PREDICTED: casein kinase I (416 aa) initn: 1849 init1: 1558 opt: 2346 Z-score: 971.2 bits: 188.7 E(85289): 2.3e-47 Smith-Waterman score: 2346; 82.0% identity (93.4% similar) in 423 aa overlap (1-422:1-416) 10 20 30 40 50 pF1KE0 MDHPSREKDERQ-RTTKPMAQRSAHCSRPSGSSSSSGVLMVGPNFRVGKKIGCGNFGELR :.. ...::. . : ..: . ::.: .: .::::: :::::::::::::::::::::::: XP_005 MENKKKDKDKSDDRMARP-SGRSGHNTRGTGSSSS-GVLMVGPNFRVGKKIGCGNFGELR 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 LGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGEGLPQVYYFGPCGKYNAMVLE :::::::::::::::::.::::::::::::::::::: :.:.:::::::::::::::::: XP_005 LGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGS-GDGIPQVYYFGPCGKYNAMVLE 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 LLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKK :::::::::::::::::.:::::::::::.::::::::::::::::::::::::: ::: XP_005 LLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKT 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 EHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGH ..:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QQVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGH 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE0 MFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEALCENFPEEMATYLRYVRRLDFF :::::::::::::::::::::::::::::::: ::::.:::::::::::::::::::::: XP_005 MFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEEMATYLRYVRRLDFF 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE0 EKPDYEYLRTLFTDLFEKKGYTFDYAYDWVGRPIPTPVGSVHVDSGASAITRESHTHRDR :::::.::: ::::::..::: ::: :::.:. .:::::.:. : . :. .::.: :::. XP_005 EKPDYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSS-NREAHQHRDK 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE0 PSQQQPLRNQVVSSTNGELNVDDPTGAHSNAPITAHAEVEVVEEAKCCCFFKRKRKKTAQ .:. .::::::::::::.::::...::::::: .::::..:.::::::::...:: : XP_005 MQQS---KNQVVSSTNGELNTDDPTAGRSNAPITAPTEVEVMDETKCCCFFKRRKRKTIQ 360 370 380 390 400 410 420 pF1KE0 RHK ::: XP_005 RHK >>XP_016864559 (OMIM: 604253) PREDICTED: casein kinase I (415 aa) initn: 1503 init1: 1212 opt: 2328 Z-score: 964.1 bits: 187.4 E(85289): 5.8e-47 Smith-Waterman score: 2328; 81.8% identity (93.1% similar) in 423 aa overlap (1-422:1-415) 10 20 30 40 50 pF1KE0 MDHPSREKDERQ-RTTKPMAQRSAHCSRPSGSSSSSGVLMVGPNFRVGKKIGCGNFGELR :.. ...::. . : ..: . ::.: .: .::::: :::::::::::::::::::::::: XP_016 MENKKKDKDKSDDRMARP-SGRSGHNTRGTGSSSS-GVLMVGPNFRVGKKIGCGNFGELR 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 LGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGEGLPQVYYFGPCGKYNAMVLE :::::::::::::::::.::::::::::::::::::: :.:.:::::::::::::::::: XP_016 LGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGS-GDGIPQVYYFGPCGKYNAMVLE 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 LLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKK :::::::::::::::::.:::::::::::.::::::::::::::::::::::::: ::: XP_016 LLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKT 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 EHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGH ..:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGH 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE0 MFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEALCENFPEEMATYLRYVRRLDFF :::::::::::::::::::::::::::::::: ::::.::::::: :::::::::::::: XP_016 MFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPE-MATYLRYVRRLDFF 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE0 EKPDYEYLRTLFTDLFEKKGYTFDYAYDWVGRPIPTPVGSVHVDSGASAITRESHTHRDR :::::.::: ::::::..::: ::: :::.:. .:::::.:. : . :. .::.: :::. XP_016 EKPDYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSS-NREAHQHRDK 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE0 PSQQQPLRNQVVSSTNGELNVDDPTGAHSNAPITAHAEVEVVEEAKCCCFFKRKRKKTAQ .:. .::::::::::::.::::...::::::: .::::..:.::::::::...:: : XP_016 MQQS---KNQVVSSTNGELNTDDPTAGRSNAPITAPTEVEVMDETKCCCFFKRRKRKTIQ 360 370 380 390 400 410 420 pF1KE0 RHK ::: XP_016 RHK >>NP_001257501 (OMIM: 604253) casein kinase I isoform ga (424 aa) initn: 1877 init1: 1558 opt: 2314 Z-score: 958.4 bits: 186.4 E(85289): 1.2e-46 Smith-Waterman score: 2314; 80.3% identity (91.6% similar) in 431 aa overlap (1-422:1-424) 10 20 30 40 50 pF1KE0 MDHPSREKDERQ-RTTKPMAQRSAHCSRPSGSSSSSGVLMVGPNFRVGKKIGCGNFGELR :.. ...::. . : ..: . ::.: .: .::::: :::::::::::::::::::::::: NP_001 MENKKKDKDKSDDRMARP-SGRSGHNTRGTGSSSS-GVLMVGPNFRVGKKIGCGNFGELR 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 LGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGEGLPQVYYFGPCGKYNAMVLE :::::::::::::::::.::::::::::::::::::: :.:.:::::::::::::::::: NP_001 LGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGS-GDGIPQVYYFGPCGKYNAMVLE 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 LLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKK :::::::::::::::::.:::::::::::.::::::::::::::::::::::::: ::: NP_001 LLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKT 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 EHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGH ..:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QQVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGH 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE0 MFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEALCENFPEEMATYLRYVRRLDFF :::::::::::::::::::::::::::::::: ::::.:::::::::::::::::::::: NP_001 MFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEEMATYLRYVRRLDFF 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE0 EKPDYEYLRTLFTDLFEKKGYTFDYAYDWVGRPIPTPVGSVHVDSGASAITRESHTHRDR :::::.::: ::::::..::: ::: :::.:. .:::::.:. : . :. .::.: :::. NP_001 EKPDYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSS-NREAHQHRDK 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE0 PSQQQPLRNQVVSSTNGELNVDDPTGAHSNAPITAHAEVEVVEEAKC--------CCFFK .:. .::::::::::::.::::...::::::: .::::..:..: ::::: NP_001 MQQS---KNQVVSSTNGELNTDDPTAGRSNAPITAPTEVEVMDETNCQKVLNMWCCCFFK 360 370 380 390 400 410 420 pF1KE0 RKRKKTAQRHK :...:: :::: NP_001 RRKRKTIQRHK 420 >>XP_005271952 (OMIM: 604253) PREDICTED: casein kinase I (424 aa) initn: 1877 init1: 1558 opt: 2314 Z-score: 958.4 bits: 186.4 E(85289): 1.2e-46 Smith-Waterman score: 2314; 80.3% identity (91.6% similar) in 431 aa overlap (1-422:1-424) 10 20 30 40 50 pF1KE0 MDHPSREKDERQ-RTTKPMAQRSAHCSRPSGSSSSSGVLMVGPNFRVGKKIGCGNFGELR :.. ...::. . : ..: . ::.: .: .::::: :::::::::::::::::::::::: XP_005 MENKKKDKDKSDDRMARP-SGRSGHNTRGTGSSSS-GVLMVGPNFRVGKKIGCGNFGELR 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 LGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGEGLPQVYYFGPCGKYNAMVLE :::::::::::::::::.::::::::::::::::::: :.:.:::::::::::::::::: XP_005 LGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGS-GDGIPQVYYFGPCGKYNAMVLE 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 LLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKK :::::::::::::::::.:::::::::::.::::::::::::::::::::::::: ::: XP_005 LLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKT 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 EHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGH ..:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QQVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGH 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE0 MFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEALCENFPEEMATYLRYVRRLDFF :::::::::::::::::::::::::::::::: ::::.:::::::::::::::::::::: XP_005 MFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEEMATYLRYVRRLDFF 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE0 EKPDYEYLRTLFTDLFEKKGYTFDYAYDWVGRPIPTPVGSVHVDSGASAITRESHTHRDR :::::.::: ::::::..::: ::: :::.:. .:::::.:. : . :. .::.: :::. XP_005 EKPDYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSS-NREAHQHRDK 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE0 PSQQQPLRNQVVSSTNGELNVDDPTGAHSNAPITAHAEVEVVEEAKC--------CCFFK .:. .::::::::::::.::::...::::::: .::::..:..: ::::: XP_005 MQQS---KNQVVSSTNGELNTDDPTAGRSNAPITAPTEVEVMDETNCQKVLNMWCCCFFK 360 370 380 390 400 410 420 pF1KE0 RKRKKTAQRHK :...:: :::: XP_005 RRKRKTIQRHK 420 >>XP_016864558 (OMIM: 604253) PREDICTED: casein kinase I (424 aa) initn: 1877 init1: 1558 opt: 2314 Z-score: 958.4 bits: 186.4 E(85289): 1.2e-46 Smith-Waterman score: 2314; 80.3% identity (91.6% similar) in 431 aa overlap (1-422:1-424) 10 20 30 40 50 pF1KE0 MDHPSREKDERQ-RTTKPMAQRSAHCSRPSGSSSSSGVLMVGPNFRVGKKIGCGNFGELR :.. ...::. . : ..: . ::.: .: .::::: :::::::::::::::::::::::: XP_016 MENKKKDKDKSDDRMARP-SGRSGHNTRGTGSSSS-GVLMVGPNFRVGKKIGCGNFGELR 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 LGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGEGLPQVYYFGPCGKYNAMVLE :::::::::::::::::.::::::::::::::::::: :.:.:::::::::::::::::: XP_016 LGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGS-GDGIPQVYYFGPCGKYNAMVLE 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 LLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKK :::::::::::::::::.:::::::::::.::::::::::::::::::::::::: ::: XP_016 LLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKT 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 EHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGH ..:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGH 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE0 MFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEALCENFPEEMATYLRYVRRLDFF :::::::::::::::::::::::::::::::: ::::.:::::::::::::::::::::: XP_016 MFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEEMATYLRYVRRLDFF 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE0 EKPDYEYLRTLFTDLFEKKGYTFDYAYDWVGRPIPTPVGSVHVDSGASAITRESHTHRDR :::::.::: ::::::..::: ::: :::.:. .:::::.:. : . :. .::.: :::. XP_016 EKPDYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSS-NREAHQHRDK 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE0 PSQQQPLRNQVVSSTNGELNVDDPTGAHSNAPITAHAEVEVVEEAKC--------CCFFK .:. .::::::::::::.::::...::::::: .::::..:..: ::::: XP_016 MQQS---KNQVVSSTNGELNTDDPTAGRSNAPITAPTEVEVMDETNCQKVLNMWCCCFFK 360 370 380 390 400 410 420 pF1KE0 RKRKKTAQRHK :...:: :::: XP_016 RRKRKTIQRHK 420 >>NP_001026982 (OMIM: 604253) casein kinase I isoform ga (423 aa) initn: 1531 init1: 1212 opt: 2296 Z-score: 951.2 bits: 185.0 E(85289): 3e-46 Smith-Waterman score: 2296; 80.0% identity (91.4% similar) in 431 aa overlap (1-422:1-423) 10 20 30 40 50 pF1KE0 MDHPSREKDERQ-RTTKPMAQRSAHCSRPSGSSSSSGVLMVGPNFRVGKKIGCGNFGELR :.. ...::. . : ..: . ::.: .: .::::: :::::::::::::::::::::::: NP_001 MENKKKDKDKSDDRMARP-SGRSGHNTRGTGSSSS-GVLMVGPNFRVGKKIGCGNFGELR 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 LGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGEGLPQVYYFGPCGKYNAMVLE :::::::::::::::::.::::::::::::::::::: :.:.:::::::::::::::::: NP_001 LGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGS-GDGIPQVYYFGPCGKYNAMVLE 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 LLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKK :::::::::::::::::.:::::::::::.::::::::::::::::::::::::: ::: NP_001 LLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKT 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 EHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGH ..:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QQVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGH 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE0 MFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEALCENFPEEMATYLRYVRRLDFF :::::::::::::::::::::::::::::::: ::::.::::::: :::::::::::::: NP_001 MFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPE-MATYLRYVRRLDFF 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE0 EKPDYEYLRTLFTDLFEKKGYTFDYAYDWVGRPIPTPVGSVHVDSGASAITRESHTHRDR :::::.::: ::::::..::: ::: :::.:. .:::::.:. : . :. .::.: :::. NP_001 EKPDYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSS-NREAHQHRDK 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE0 PSQQQPLRNQVVSSTNGELNVDDPTGAHSNAPITAHAEVEVVEEAKC--------CCFFK .:. .::::::::::::.::::...::::::: .::::..:..: ::::: NP_001 MQQS---KNQVVSSTNGELNTDDPTAGRSNAPITAPTEVEVMDETNCQKVLNMWCCCFFK 360 370 380 390 400 410 420 pF1KE0 RKRKKTAQRHK :...:: :::: NP_001 RRKRKTIQRHK 420 422 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 03:01:39 2016 done: Sat Nov 5 03:01:41 2016 Total Scan time: 9.020 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]