Result of FASTA (omim) for
pF1KE0736
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0736, 423 aa
1>>>pF1KE0736 423 - 423 aa - 423 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.6365+/-0.00036; mu= -1.2964+/- 0.023
mean_var=274.3993+/-57.481, 0's: 0 Z-trim(122.7): 65 B-trim: 2 in 1/54
Lambda= 0.077425
statistics sampled from 41114 (41213) to 41114 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.801), E-opt: 0.2 (0.483), width: 16
Scan time: 7.780
The best scores are: opt bits E(85289)
NP_003019 (OMIM: 600314) SH2 domain-containing ada ( 509) 708 92.1 3.4e-18
NP_001010846 (OMIM: 610482) SH2 domain-containing ( 495) 544 73.8 1.1e-12
XP_011507465 (OMIM: 610482) PREDICTED: SH2 domain- ( 495) 544 73.8 1.1e-12
NP_064594 (OMIM: 610481) SH2 domain-containing ada ( 340) 535 72.6 1.7e-12
XP_005244948 (OMIM: 610482) PREDICTED: SH2 domain- ( 440) 309 47.5 8e-05
>>NP_003019 (OMIM: 600314) SH2 domain-containing adapter (509 aa)
initn: 740 init1: 436 opt: 708 Z-score: 447.6 bits: 92.1 E(85289): 3.4e-18
Smith-Waterman score: 961; 44.1% identity (65.7% similar) in 408 aa overlap (22-423:169-509)
10 20 30 40 50
pF1KE0 MQQEGGPVRSAPCRTGTLEGSRQGSPGHRKRASPKGSLSSAQPHSWMLTPS
: ..:.. . ::: : ... . . .
NP_003 CCCASSGAGAAASSSSSSGSPHLYRSSSERRPATPAEVRYISPKHRLIKVESAAGGGAGD
140 150 160 170 180 190
60 70 80 90 100 110
pF1KE0 PLNSHCAHREPISSSPQPVANGPKQKKKSNWRSTTRLRIIRLRDRLEPRPLAILEDYADP
::.. :: . : :.: : :. .. :... .:.. .: .::.::
NP_003 PLGGACAGGRTWS----PTACGGKKLLNKCAASAAEESGAGKKDKV-----TIADDYSDP
200 210 220 230 240
120 130 140 150 160
pF1KE0 FDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQP--LPLYDTPYE
::... ...:: . :. :::::::::..:.:.. .. . .: . :::::::
NP_003 FDAKNDLKSKAGKG-------ESAGYMEPYEAQRIMTEFQRQESVRSQHKGIQLYDTPYE
250 260 270 280 290 300
170 180 190 200 210 220
pF1KE0 PEEDGATPEGEG--APWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLP
:: ... ..:. .: :::.::.::.:: .::::::::.. :
NP_003 PEGQSVDSDSESTVSPRLRESKLPQDDDRPADEYDQPWEWNRVTI---------------
310 320 330 340
230 240 250 260 270 280
pF1KE0 WPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEK--SCLSPGREEKGRL
:.: .:::.: :: : ::.:... .:
NP_003 -----------PAL----------------------AAQFNGNEKRQSSPSPSRDRRRQL
350 360 370
290 300 310 320 330 340
pF1KE0 PPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASY
: .:. : : : : . ::: .:::.:::.:.:::::::: ::::::::::: ::
NP_003 --RAPGGGFKPIKHGSPEFCGILGERVDPAVPLEKQIWYHGAISRGDAENLLRLCKECSY
380 390 400 410 420 430
350 360 370 380 390 400
pF1KE0 LVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLP
:::::.:::.:.::::.:.::::::::..::: :::::::::::.::::..:.:..::::
NP_003 LVRNSQTSKHDYSLSLRSNQGFMHMKLAKTKE-KYVLGQNSPPFDSVPEVIHYYTTRKLP
440 450 460 470 480 490
410 420
pF1KE0 IKGAEHMSLLYPVAIRTL
::::::.:::::::.:::
NP_003 IKGAEHLSLLYPVAVRTL
500
>>NP_001010846 (OMIM: 610482) SH2 domain-containing adap (495 aa)
initn: 885 init1: 468 opt: 544 Z-score: 348.8 bits: 73.8 E(85289): 1.1e-12
Smith-Waterman score: 781; 40.3% identity (58.2% similar) in 404 aa overlap (50-418:162-490)
20 30 40 50 60 70
pF1KE0 GSRQGSPGHRKRASPKGSLSSAQPHSWMLTPSPLNSHCAHREPISSSPQPVANGPKQKKK
:: .: . ::::. . ::. :
NP_001 RGATKSSGCSTYINRLIKVDTQEKNGKSNYPSSSSSSSSSSSSASSSPSSL--GPELDKG
140 150 160 170 180
80 90 100 110 120 130
pF1KE0 SNWRSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYME
.::. .. . ::::::::.:...: .:. : :.: :::::::
NP_001 ---------KIIKQQETV-----IILEDYADPYDAKRT-KGQRDA----ERVGENDGYME
190 200 210 220 230
140 150 160
pF1KE0 PYEAQKMMAEIR--GSKET---ATQ------------------------------PLPLY
::.::.:..::: :::. : : : ::
NP_001 PYDAQQMITEIRRRGSKDPLVKALQLLDSPCEPADGGLKSETLAKRRSSKDLLGKPPQLY
240 250 260 270 280 290
170 180 190 200 210 220
pF1KE0 DTPYEPEEDGATPEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIK
:::::: : : :..:: : .:::::.:::: ::.::::::::.: .:..:
NP_001 DTPYEPAEGG--PRAEGKARPPDSRLPENDERPAAEYEQPWEWKKEQIVRALSV------
300 310 320 330 340
230 240 250 260 270 280
pF1KE0 DLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGR
:::: :. . ::: :
NP_001 -----------------------------------------QFEGAERPSF---REETVR
350
290 300 310 320 330 340
pF1KE0 LPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEAS
: .. . : :: . : :: .::.::::.: ::::::::..::. :. ::::.
NP_001 QHHRQKSWTQKILKPALSDHSE--GEKVDPGLPLEKQPWYHGAISRAEAESRLQPCKEAG
360 370 380 390 400 410
350 360 370 380 390 400
pF1KE0 YLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKL
:::::::.... .:..::.::: .:. ...::..::.:.:.: :.:.::.::.:...::
NP_001 YLVRNSESGNSRYSIALKTSQGCVHIIVAQTKDNKYTLNQTSAVFDSIPEVVHYYSNEKL
420 430 440 450 460 470
410 420
pF1KE0 PIKGAEHMSLLYPVAIRTL
:.::::::.:::::
NP_001 PFKGAEHMTLLYPVHSKLH
480 490
>>XP_011507465 (OMIM: 610482) PREDICTED: SH2 domain-cont (495 aa)
initn: 885 init1: 468 opt: 544 Z-score: 348.8 bits: 73.8 E(85289): 1.1e-12
Smith-Waterman score: 781; 40.3% identity (58.2% similar) in 404 aa overlap (50-418:162-490)
20 30 40 50 60 70
pF1KE0 GSRQGSPGHRKRASPKGSLSSAQPHSWMLTPSPLNSHCAHREPISSSPQPVANGPKQKKK
:: .: . ::::. . ::. :
XP_011 RGATKSSGCSTYINRLIKVDTQEKNGKSNYPSSSSSSSSSSSSASSSPSSL--GPELDKG
140 150 160 170 180
80 90 100 110 120 130
pF1KE0 SNWRSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYME
.::. .. . ::::::::.:...: .:. : :.: :::::::
XP_011 ---------KIIKQQETV-----IILEDYADPYDAKRT-KGQRDA----ERVGENDGYME
190 200 210 220 230
140 150 160
pF1KE0 PYEAQKMMAEIR--GSKET---ATQ------------------------------PLPLY
::.::.:..::: :::. : : : ::
XP_011 PYDAQQMITEIRRRGSKDPLVKALQLLDSPCEPADGGLKSETLAKRRSSKDLLGKPPQLY
240 250 260 270 280 290
170 180 190 200 210 220
pF1KE0 DTPYEPEEDGATPEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIK
:::::: : : :..:: : .:::::.:::: ::.::::::::.: .:..:
XP_011 DTPYEPAEGG--PRAEGKARPPDSRLPENDERPAAEYEQPWEWKKEQIVRALSV------
300 310 320 330 340
230 240 250 260 270 280
pF1KE0 DLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGR
:::: :. . ::: :
XP_011 -----------------------------------------QFEGAERPSF---REETVR
350
290 300 310 320 330 340
pF1KE0 LPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEAS
: .. . : :: . : :: .::.::::.: ::::::::..::. :. ::::.
XP_011 QHHRQKSWTQKILKPALSDHSE--GEKVDPGLPLEKQPWYHGAISRAEAESRLQPCKEAG
360 370 380 390 400 410
350 360 370 380 390 400
pF1KE0 YLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKL
:::::::.... .:..::.::: .:. ...::..::.:.:.: :.:.::.::.:...::
XP_011 YLVRNSESGNSRYSIALKTSQGCVHIIVAQTKDNKYTLNQTSAVFDSIPEVVHYYSNEKL
420 430 440 450 460 470
410 420
pF1KE0 PIKGAEHMSLLYPVAIRTL
:.::::::.:::::
XP_011 PFKGAEHMTLLYPVHSKLH
480 490
>>NP_064594 (OMIM: 610481) SH2 domain-containing adapter (340 aa)
initn: 876 init1: 507 opt: 535 Z-score: 345.5 bits: 72.6 E(85289): 1.7e-12
Smith-Waterman score: 806; 40.9% identity (60.8% similar) in 367 aa overlap (67-422:55-339)
40 50 60 70 80 90
pF1KE0 SLSSAQPHSWMLTPSPLNSHCAHREPISSSPQPVANGPKQKKKSNWRSTTRLRIIRLRDR
:.:.. : ... . .. . :.:...
NP_064 YTESDILRAYRAQKNLDFEDPYEDAESRLEPDPAGPGDSKNPGDAKYGSPKHRLIKVEAA
30 40 50 60 70 80
100 110 120 130 140
pF1KE0 LEPRPLAIL----------EDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKM
: :.: .: ::::.: :. .: .:::::::.:: .
NP_064 DMARAKALLGGPGEELEADTEYLDPFDAQ------------PHPAPPDDGYMEPYDAQWV
90 100 110 120 130
150 160 170 180 190 200
pF1KE0 MAEIRGSKETATQPLPLYDTPYEPEEDGATPEGEGAPW-PRESRLPEDDERPPEEYDQPW
:.:. : . . ::::::: :.: : .: . ::.::.:..:::: .::::::
NP_064 MSELPG------RGVQLYDTPYE-EQDPETADGPPSGQKPRQSRMPQEDERPADEYDQPW
140 150 160 170 180
210 220 230 240 250 260
pF1KE0 EWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSA
::::..::.:::: :.:: :. .:
NP_064 EWKKDHISRAFAV---------------QFDS----PEWER-------------------
190 200
270 280 290 300 310 320
pF1KE0 QFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYH
.:: .. : :: :.: .: .: .:::::::.: :.:
NP_064 ----------TPGSAKELRRPP------PRSPQP---------AERVDPALPLEKQPWFH
210 220 230 240
330 340 350 360 370 380
pF1KE0 GAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQN
: ..:.:::.:: ::::.::::: :::. .: ::::.:::::.:.:..::.:.. ::::.
NP_064 GPLNRADAESLLSLCKEGSYLVRLSETNPQDCSLSLRSSQGFLHLKFARTRENQVVLGQH
250 260 270 280 290 300
390 400 410 420
pF1KE0 SPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL
: :: ::::.: ::.:: ::..::::..:::::. .:
NP_064 SGPFPSVPELVLHYSSRPLPVQGAEHLALLYPVVTQTP
310 320 330 340
>>XP_005244948 (OMIM: 610482) PREDICTED: SH2 domain-cont (440 aa)
initn: 650 init1: 233 opt: 309 Z-score: 207.6 bits: 47.5 E(85289): 8e-05
Smith-Waterman score: 546; 37.5% identity (52.7% similar) in 349 aa overlap (50-363:162-435)
20 30 40 50 60 70
pF1KE0 GSRQGSPGHRKRASPKGSLSSAQPHSWMLTPSPLNSHCAHREPISSSPQPVANGPKQKKK
:: .: . ::::. . ::. :
XP_005 RGATKSSGCSTYINRLIKVDTQEKNGKSNYPSSSSSSSSSSSSASSSPSSL--GPELDKG
140 150 160 170 180
80 90 100 110 120 130
pF1KE0 SNWRSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYME
.::. .. . ::::::::.:...: .:. : :.: :::::::
XP_005 ---------KIIKQQETV-----IILEDYADPYDAKRT-KGQRDA----ERVGENDGYME
190 200 210 220 230
140 150 160
pF1KE0 PYEAQKMMAEIR--GSKET---ATQ------------------------------PLPLY
::.::.:..::: :::. : : : ::
XP_005 PYDAQQMITEIRRRGSKDPLVKALQLLDSPCEPADGGLKSETLAKRRSSKDLLGKPPQLY
240 250 260 270 280 290
170 180 190 200 210 220
pF1KE0 DTPYEPEEDGATPEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIK
:::::: : : :..:: : .:::::.:::: ::.::::::::.: .:..:
XP_005 DTPYEPAEGG--PRAEGKARPPDSRLPENDERPAAEYEQPWEWKKEQIVRALSV------
300 310 320 330 340
230 240 250 260 270 280
pF1KE0 DLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGR
:::: :. . ::: :
XP_005 -----------------------------------------QFEGAERPSF---REETVR
350
290 300 310 320 330 340
pF1KE0 LPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEAS
: .. . : :: . : :: .::.::::.: ::::::::..::. :. ::::.
XP_005 QHHRQKSWTQKILKPALSDHSE--GEKVDPGLPLEKQPWYHGAISRAEAESRLQPCKEAG
360 370 380 390 400 410
350 360 370 380 390 400
pF1KE0 YLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKL
:::::::.... .:..::.
XP_005 YLVRNSESGNSRYSIALKNHHLLS
420 430 440
423 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 04:22:21 2016 done: Sat Nov 5 04:22:22 2016
Total Scan time: 7.780 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]