FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0742, 424 aa 1>>>pF1KE0742 424 - 424 aa - 424 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.3349+/-0.000461; mu= 5.4541+/- 0.028 mean_var=498.5456+/-112.314, 0's: 0 Z-trim(119.6): 1841 B-trim: 0 in 0/58 Lambda= 0.057441 statistics sampled from 31402 (33876) to 31402 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.733), E-opt: 0.2 (0.397), width: 16 Scan time: 9.940 The best scores are: opt bits E(85289) NP_006733 (OMIM: 177015) serine/threonine-protein ( 424) 2807 247.6 4.5e-65 XP_006717546 (OMIM: 607957) PREDICTED: calcium/cal ( 355) 940 92.8 1.5e-18 NP_065130 (OMIM: 607957) calcium/calmodulin-depend ( 357) 940 92.8 1.5e-18 XP_006717545 (OMIM: 607957) PREDICTED: calcium/cal ( 362) 940 92.8 1.6e-18 NP_705718 (OMIM: 607957) calcium/calmodulin-depend ( 385) 940 92.8 1.6e-18 NP_003647 (OMIM: 604998) calcium/calmodulin-depend ( 370) 925 91.5 3.7e-18 XP_005265573 (OMIM: 604998) PREDICTED: calcium/cal ( 413) 925 91.6 3.9e-18 XP_006717544 (OMIM: 607957) PREDICTED: calcium/cal ( 366) 921 91.2 4.6e-18 XP_011517893 (OMIM: 607957) PREDICTED: calcium/cal ( 372) 921 91.2 4.7e-18 XP_016884766 (OMIM: 300680) PREDICTED: calcium/cal ( 426) 866 86.8 1.2e-16 NP_001034671 (OMIM: 300680) calcium/calmodulin-dep ( 426) 866 86.8 1.2e-16 XP_016884768 (OMIM: 300680) PREDICTED: calcium/cal ( 343) 861 86.2 1.4e-16 XP_005274708 (OMIM: 300680) PREDICTED: calcium/cal ( 343) 861 86.2 1.4e-16 XP_011529414 (OMIM: 300680) PREDICTED: calcium/cal ( 343) 861 86.2 1.4e-16 XP_006724872 (OMIM: 300680) PREDICTED: calcium/cal ( 343) 861 86.2 1.4e-16 XP_011529409 (OMIM: 300680) PREDICTED: calcium/cal ( 343) 861 86.2 1.4e-16 XP_011529413 (OMIM: 300680) PREDICTED: calcium/cal ( 343) 861 86.2 1.4e-16 XP_016884767 (OMIM: 300680) PREDICTED: calcium/cal ( 343) 861 86.2 1.4e-16 XP_011529412 (OMIM: 300680) PREDICTED: calcium/cal ( 343) 861 86.2 1.4e-16 NP_001129212 (OMIM: 300680) calcium/calmodulin-dep ( 360) 861 86.2 1.4e-16 XP_011529410 (OMIM: 300680) PREDICTED: calcium/cal ( 361) 861 86.2 1.4e-16 XP_011517895 (OMIM: 607957) PREDICTED: calcium/cal ( 311) 821 82.8 1.3e-15 XP_011517894 (OMIM: 607957) PREDICTED: calcium/cal ( 315) 821 82.8 1.4e-15 XP_016862843 (OMIM: 604998) PREDICTED: calcium/cal ( 326) 821 82.8 1.4e-15 XP_005265574 (OMIM: 604998) PREDICTED: calcium/cal ( 369) 821 82.9 1.5e-15 XP_016857355 (OMIM: 614994) PREDICTED: calcium/cal ( 476) 821 83.1 1.6e-15 NP_065172 (OMIM: 614994) calcium/calmodulin-depend ( 476) 821 83.1 1.6e-15 NP_001735 (OMIM: 114080) calcium/calmodulin-depend ( 473) 801 81.5 5.2e-15 NP_001310303 (OMIM: 114080) calcium/calmodulin-dep ( 473) 801 81.5 5.2e-15 NP_001310304 (OMIM: 114080) calcium/calmodulin-dep ( 473) 801 81.5 5.2e-15 XP_016871928 (OMIM: 607957) PREDICTED: calcium/cal ( 260) 754 77.1 5.8e-14 XP_011517897 (OMIM: 607957) PREDICTED: calcium/cal ( 288) 754 77.2 6.1e-14 XP_016871927 (OMIM: 607957) PREDICTED: calcium/cal ( 288) 754 77.2 6.1e-14 XP_016864166 (OMIM: 607708) PREDICTED: calcium/cal ( 491) 745 76.8 1.3e-13 NP_001308506 (OMIM: 607708) calcium/calmodulin-dep ( 491) 745 76.8 1.3e-13 XP_016864163 (OMIM: 607708) PREDICTED: calcium/cal ( 511) 745 76.9 1.3e-13 XP_016864162 (OMIM: 607708) PREDICTED: calcium/cal ( 512) 745 76.9 1.3e-13 XP_005263311 (OMIM: 607708) PREDICTED: calcium/cal ( 532) 745 76.9 1.4e-13 XP_006714393 (OMIM: 607708) PREDICTED: calcium/cal ( 478) 744 76.7 1.4e-13 NP_001308512 (OMIM: 607708) calcium/calmodulin-dep ( 492) 744 76.8 1.4e-13 NP_001308504 (OMIM: 607708) calcium/calmodulin-dep ( 492) 744 76.8 1.4e-13 NP_001308497 (OMIM: 607708) calcium/calmodulin-dep ( 503) 744 76.8 1.4e-13 XP_011530597 (OMIM: 607708) PREDICTED: calcium/cal ( 510) 744 76.8 1.4e-13 NP_001308501 (OMIM: 607708) calcium/calmodulin-dep ( 512) 744 76.8 1.4e-13 NP_001308496 (OMIM: 607708) calcium/calmodulin-dep ( 512) 744 76.8 1.4e-13 XP_016864161 (OMIM: 607708) PREDICTED: calcium/cal ( 513) 744 76.8 1.4e-13 NP_001308500 (OMIM: 607708) calcium/calmodulin-dep ( 533) 744 76.8 1.4e-13 NP_001305866 (OMIM: 601685) ribosomal protein S6 k ( 635) 744 76.9 1.6e-13 NP_001305867 (OMIM: 601685) ribosomal protein S6 k ( 644) 744 77.0 1.6e-13 NP_066958 (OMIM: 601685) ribosomal protein S6 kina ( 733) 744 77.1 1.7e-13 >>NP_006733 (OMIM: 177015) serine/threonine-protein kina (424 aa) initn: 2807 init1: 2807 opt: 2807 Z-score: 1289.3 bits: 247.6 E(85289): 4.5e-65 Smith-Waterman score: 2807; 100.0% identity (100.0% similar) in 424 aa overlap (1-424:1-424) 10 20 30 40 50 60 pF1KE0 MGCGTSKVLPEPPKDVQLDLVKKVEPFSGTKSDVYKHFITEVDSVGPVKAGFPAASQYAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MGCGTSKVLPEPPKDVQLDLVKKVEPFSGTKSDVYKHFITEVDSVGPVKAGFPAASQYAH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 PCPGPPTAGHTEPPSEPPRRARVAKYRAKFDPRVTAKYDIKALIGRGSFSRVVRVEHRAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 PCPGPPTAGHTEPPSEPPRRARVAKYRAKFDPRVTAKYDIKALIGRGSFSRVVRVEHRAT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 RQPYAIKMIETKYREGREVCESELRVLRRVRHANIIQLVEVFETQERVYMVMELATGGEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 RQPYAIKMIETKYREGREVCESELRVLRRVRHANIIQLVEVFETQERVYMVMELATGGEL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 FDRIIAKGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIITDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 FDRIIAKGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIITDF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 GLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 GLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 NRTRLYRQILRGKYSYSGEPWPSVSNLAKDFIDRLLTVDPGARMTALQALRHPWVVSMAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 NRTRLYRQILRGKYSYSGEPWPSVSNLAKDFIDRLLTVDPGARMTALQALRHPWVVSMAA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 SSSMKNLHRSISQNLLKRASSRCQSTKSAQSTRSSRSTRSNKSRRVRERELRELNLRYQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 SSSMKNLHRSISQNLLKRASSRCQSTKSAQSTRSSRSTRSNKSRRVRERELRELNLRYQQ 370 380 390 400 410 420 pF1KE0 QYNG :::: NP_006 QYNG >>XP_006717546 (OMIM: 607957) PREDICTED: calcium/calmodu (355 aa) initn: 867 init1: 437 opt: 940 Z-score: 453.8 bits: 92.8 E(85289): 1.5e-18 Smith-Waterman score: 940; 48.8% identity (79.4% similar) in 281 aa overlap (98-377:23-299) 70 80 90 100 110 120 pF1KE0 AGHTEPPSEPPRRARVAKYRAKFDPRVTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIK ...: .: :.::.:: .:..:: . .:.: XP_006 MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVK 10 20 30 40 50 130 140 150 160 170 180 pF1KE0 MIETKYREGREVC-ESELRVLRRVRHANIIQLVEVFETQERVYMVMELATGGELFDRIIA : : .:.: :.:. :::...: ::. : ...:. ...:.::.:..::::::::. XP_006 CIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVE 60 70 80 90 100 110 190 200 210 220 230 240 pF1KE0 KGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIITDFGLASAR :: .::.::. ....:::.: ::: .::.:::::::::::: .:::.:.::::.. . XP_006 KGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKME 120 130 140 150 160 170 250 260 270 280 290 300 pF1KE0 KKGDDCLMKTTCGTPEYIAPEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLY ::: .:.:.:::: :.:::::..:::...:: :..:::::::: : :: :.: ..:. XP_006 GKGD--VMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLF 180 190 200 210 220 230 310 320 330 340 350 360 pF1KE0 RQILRGKYSYSGEPWPSVSNLAKDFIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKN .:::...: ... : ..:. ::::: :. ::. :.: :: ::::... .: . :: XP_006 EQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALN--KN 240 250 260 270 280 370 380 390 400 410 420 pF1KE0 LHRSISQNLLKRASSRCQSTKSAQSTRSSRSTRSNKSRRVRERELRELNLRYQQQYNG .:.:.: .. : XP_006 IHESVSAQIRKNFAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQKDCA 290 300 310 320 330 340 >>NP_065130 (OMIM: 607957) calcium/calmodulin-dependent (357 aa) initn: 867 init1: 437 opt: 940 Z-score: 453.8 bits: 92.8 E(85289): 1.5e-18 Smith-Waterman score: 940; 48.8% identity (79.4% similar) in 281 aa overlap (98-377:23-299) 70 80 90 100 110 120 pF1KE0 AGHTEPPSEPPRRARVAKYRAKFDPRVTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIK ...: .: :.::.:: .:..:: . .:.: NP_065 MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVK 10 20 30 40 50 130 140 150 160 170 180 pF1KE0 MIETKYREGREVC-ESELRVLRRVRHANIIQLVEVFETQERVYMVMELATGGELFDRIIA : : .:.: :.:. :::...: ::. : ...:. ...:.::.:..::::::::. NP_065 CIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVE 60 70 80 90 100 110 190 200 210 220 230 240 pF1KE0 KGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIITDFGLASAR :: .::.::. ....:::.: ::: .::.:::::::::::: .:::.:.::::.. . NP_065 KGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKME 120 130 140 150 160 170 250 260 270 280 290 300 pF1KE0 KKGDDCLMKTTCGTPEYIAPEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLY ::: .:.:.:::: :.:::::..:::...:: :..:::::::: : :: :.: ..:. NP_065 GKGD--VMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLF 180 190 200 210 220 230 310 320 330 340 350 360 pF1KE0 RQILRGKYSYSGEPWPSVSNLAKDFIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKN .:::...: ... : ..:. ::::: :. ::. :.: :: ::::... .: . :: NP_065 EQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALN--KN 240 250 260 270 280 370 380 390 400 410 420 pF1KE0 LHRSISQNLLKRASSRCQSTKSAQSTRSSRSTRSNKSRRVRERELRELNLRYQQQYNG .:.:.: .. : NP_065 IHESVSAQIRKNFAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQKDCA 290 300 310 320 330 340 >>XP_006717545 (OMIM: 607957) PREDICTED: calcium/calmodu (362 aa) initn: 902 init1: 437 opt: 940 Z-score: 453.8 bits: 92.8 E(85289): 1.6e-18 Smith-Waterman score: 940; 48.8% identity (79.4% similar) in 281 aa overlap (98-377:23-299) 70 80 90 100 110 120 pF1KE0 AGHTEPPSEPPRRARVAKYRAKFDPRVTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIK ...: .: :.::.:: .:..:: . .:.: XP_006 MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVK 10 20 30 40 50 130 140 150 160 170 180 pF1KE0 MIETKYREGREVC-ESELRVLRRVRHANIIQLVEVFETQERVYMVMELATGGELFDRIIA : : .:.: :.:. :::...: ::. : ...:. ...:.::.:..::::::::. XP_006 CIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVE 60 70 80 90 100 110 190 200 210 220 230 240 pF1KE0 KGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIITDFGLASAR :: .::.::. ....:::.: ::: .::.:::::::::::: .:::.:.::::.. . XP_006 KGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKME 120 130 140 150 160 170 250 260 270 280 290 300 pF1KE0 KKGDDCLMKTTCGTPEYIAPEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLY ::: .:.:.:::: :.:::::..:::...:: :..:::::::: : :: :.: ..:. XP_006 GKGD--VMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLF 180 190 200 210 220 230 310 320 330 340 350 360 pF1KE0 RQILRGKYSYSGEPWPSVSNLAKDFIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKN .:::...: ... : ..:. ::::: :. ::. :.: :: ::::... .: . :: XP_006 EQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALN--KN 240 250 260 270 280 370 380 390 400 410 420 pF1KE0 LHRSISQNLLKRASSRCQSTKSAQSTRSSRSTRSNKSRRVRERELRELNLRYQQQYNG .:.:.: .. : XP_006 IHESVSAQIRKNFAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNVWHLPRSVVSFLLRRG 290 300 310 320 330 340 >>NP_705718 (OMIM: 607957) calcium/calmodulin-dependent (385 aa) initn: 888 init1: 437 opt: 940 Z-score: 453.5 bits: 92.8 E(85289): 1.6e-18 Smith-Waterman score: 940; 48.8% identity (79.4% similar) in 281 aa overlap (98-377:23-299) 70 80 90 100 110 120 pF1KE0 AGHTEPPSEPPRRARVAKYRAKFDPRVTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIK ...: .: :.::.:: .:..:: . .:.: NP_705 MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVK 10 20 30 40 50 130 140 150 160 170 180 pF1KE0 MIETKYREGREVC-ESELRVLRRVRHANIIQLVEVFETQERVYMVMELATGGELFDRIIA : : .:.: :.:. :::...: ::. : ...:. ...:.::.:..::::::::. NP_705 CIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVE 60 70 80 90 100 110 190 200 210 220 230 240 pF1KE0 KGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIITDFGLASAR :: .::.::. ....:::.: ::: .::.:::::::::::: .:::.:.::::.. . NP_705 KGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKME 120 130 140 150 160 170 250 260 270 280 290 300 pF1KE0 KKGDDCLMKTTCGTPEYIAPEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLY ::: .:.:.:::: :.:::::..:::...:: :..:::::::: : :: :.: ..:. NP_705 GKGD--VMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLF 180 190 200 210 220 230 310 320 330 340 350 360 pF1KE0 RQILRGKYSYSGEPWPSVSNLAKDFIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKN .:::...: ... : ..:. ::::: :. ::. :.: :: ::::... .: . :: NP_705 EQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALN--KN 240 250 260 270 280 370 380 390 400 410 420 pF1KE0 LHRSISQNLLKRASSRCQSTKSAQSTRSSRSTRSNKSRRVRERELRELNLRYQQQYNG .:.:.: .. : NP_705 IHESVSAQIRKNFAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQKDCL 290 300 310 320 330 340 >>NP_003647 (OMIM: 604998) calcium/calmodulin-dependent (370 aa) initn: 886 init1: 426 opt: 925 Z-score: 447.0 bits: 91.5 E(85289): 3.7e-18 Smith-Waterman score: 925; 45.9% identity (77.2% similar) in 303 aa overlap (98-399:20-317) 70 80 90 100 110 120 pF1KE0 AGHTEPPSEPPRRARVAKYRAKFDPRVTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIK ::.. ..: :.::.:. .: . :.. ::: NP_003 MLGAVEGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIK 10 20 30 40 130 140 150 160 170 180 pF1KE0 MIETKYREGRE-VCESELRVLRRVRHANIIQLVEVFETQERVYMVMELATGGELFDRIIA : . ::.: :.:. ::....: ::. : ...:. ..:..:.:..::::::::. NP_003 CIAKEALEGKEGSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVE 50 60 70 80 90 100 190 200 210 220 230 240 pF1KE0 KGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIITDFGLASAR :: .:::::.:.. .:::.:.::: :::.:::::::::::: ::::.:.::::.. . NP_003 KGFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKME 110 120 130 140 150 160 250 260 270 280 290 300 pF1KE0 KKGDDCLMKTTCGTPEYIAPEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLY :. ...:.:::: :.:::::..:::...:: :..:::::::: : :: :.: ..:. NP_003 DPGS--VLSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLF 170 180 190 200 210 220 310 320 330 340 350 360 pF1KE0 RQILRGKYSYSGEPWPSVSNLAKDFIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKN .:::...: ... : ..:. ::::: .:. :: :.: :::.:::... .: . :: NP_003 EQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALD--KN 230 240 250 260 270 280 370 380 390 400 410 420 pF1KE0 LHRSISQNLLKRASSRCQSTKSAQSTRSSRSTRSNKSRRVRERELRELNLRYQQQYNG .:.:.:... :. .. . .. ..: : : NP_003 IHQSVSEQI-KKNFAKSKWKQAFNATAVVRHMRKLQLGTSQEGQGQTASHGELLTPVAGG 290 300 310 320 330 340 NP_003 PAAGCCCRDCCVEPGTELSPTLPHQL 350 360 370 >>XP_005265573 (OMIM: 604998) PREDICTED: calcium/calmodu (413 aa) initn: 886 init1: 426 opt: 925 Z-score: 446.5 bits: 91.6 E(85289): 3.9e-18 Smith-Waterman score: 925; 45.9% identity (77.2% similar) in 303 aa overlap (98-399:20-317) 70 80 90 100 110 120 pF1KE0 AGHTEPPSEPPRRARVAKYRAKFDPRVTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIK ::.. ..: :.::.:. .: . :.. ::: XP_005 MLGAVEGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIK 10 20 30 40 130 140 150 160 170 180 pF1KE0 MIETKYREGRE-VCESELRVLRRVRHANIIQLVEVFETQERVYMVMELATGGELFDRIIA : . ::.: :.:. ::....: ::. : ...:. ..:..:.:..::::::::. XP_005 CIAKEALEGKEGSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVE 50 60 70 80 90 100 190 200 210 220 230 240 pF1KE0 KGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIITDFGLASAR :: .:::::.:.. .:::.:.::: :::.:::::::::::: ::::.:.::::.. . XP_005 KGFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKME 110 120 130 140 150 160 250 260 270 280 290 300 pF1KE0 KKGDDCLMKTTCGTPEYIAPEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLY :. ...:.:::: :.:::::..:::...:: :..:::::::: : :: :.: ..:. XP_005 DPGS--VLSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLF 170 180 190 200 210 220 310 320 330 340 350 360 pF1KE0 RQILRGKYSYSGEPWPSVSNLAKDFIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKN .:::...: ... : ..:. ::::: .:. :: :.: :::.:::... .: . :: XP_005 EQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALD--KN 230 240 250 260 270 280 370 380 390 400 410 420 pF1KE0 LHRSISQNLLKRASSRCQSTKSAQSTRSSRSTRSNKSRRVRERELRELNLRYQQQYNG .:.:.:... :. .. . .. ..: : : XP_005 IHQSVSEQI-KKNFAKSKWKQAFNATAVVRHMRKLQLGTSQEGQGQTASHGELLTPVAGG 290 300 310 320 330 340 XP_005 EERALQKGMGGPQRCTRAGVEGLPLRPPLFCLPMQGRQLAVAVETAAWSRAQNCPPHCPT 350 360 370 380 390 400 >>XP_006717544 (OMIM: 607957) PREDICTED: calcium/calmodu (366 aa) initn: 869 init1: 437 opt: 921 Z-score: 445.2 bits: 91.2 E(85289): 4.6e-18 Smith-Waterman score: 921; 49.6% identity (79.8% similar) in 272 aa overlap (107-377:13-280) 80 90 100 110 120 130 pF1KE0 PPRRARVAKYRAKFDPRVTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREG :.::.:: .:..:: . .:.: : : .: XP_006 MNVDLLSCALWSGAFSEVVLAEEKATGKLFAVKCIPKKALKG 10 20 30 40 140 150 160 170 180 190 pF1KE0 REVC-ESELRVLRRVRHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDA .: :.:. :::...: ::. : ...:. ...:.::.:..::::::::. :: .::.:: XP_006 KESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDA 50 60 70 80 90 100 200 210 220 230 240 250 pF1KE0 TRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMK . ....:::.: ::: .::.:::::::::::: .:::.:.::::.. . ::: .:. XP_006 STLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGD--VMS 110 120 130 140 150 160 260 270 280 290 300 310 pF1KE0 TTCGTPEYIAPEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYS :.:::: :.:::::..:::...:: :..:::::::: : :: :.: ..:..:::...: XP_006 TACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYE 170 180 190 200 210 220 320 330 340 350 360 370 pF1KE0 YSGEPWPSVSNLAKDFIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNL ... : ..:. ::::: :. ::. :.: :: ::::... .: . ::.:.:.: .. XP_006 FDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALN--KNIHESVSAQI 230 240 250 260 270 380 390 400 410 420 pF1KE0 LKRASSRCQSTKSAQSTRSSRSTRSNKSRRVRERELRELNLRYQQQYNG : XP_006 RKNFAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQKDCLAPSTLCSFI 280 290 300 310 320 330 >>XP_011517893 (OMIM: 607957) PREDICTED: calcium/calmodu (372 aa) initn: 869 init1: 437 opt: 921 Z-score: 445.1 bits: 91.2 E(85289): 4.7e-18 Smith-Waterman score: 921; 49.6% identity (79.8% similar) in 272 aa overlap (107-377:19-286) 80 90 100 110 120 130 pF1KE0 PPRRARVAKYRAKFDPRVTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREG :.::.:: .:..:: . .:.: : : .: XP_011 METPPYSMEGPSCPICPSGAFSEVVLAEEKATGKLFAVKCIPKKALKG 10 20 30 40 140 150 160 170 180 190 pF1KE0 REVC-ESELRVLRRVRHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDA .: :.:. :::...: ::. : ...:. ...:.::.:..::::::::. :: .::.:: XP_011 KESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDA 50 60 70 80 90 100 200 210 220 230 240 250 pF1KE0 TRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMK . ....:::.: ::: .::.:::::::::::: .:::.:.::::.. . ::: .:. XP_011 STLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGD--VMS 110 120 130 140 150 160 260 270 280 290 300 310 pF1KE0 TTCGTPEYIAPEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYS :.:::: :.:::::..:::...:: :..:::::::: : :: :.: ..:..:::...: XP_011 TACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYE 170 180 190 200 210 220 320 330 340 350 360 370 pF1KE0 YSGEPWPSVSNLAKDFIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNL ... : ..:. ::::: :. ::. :.: :: ::::... .: . ::.:.:.: .. XP_011 FDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALN--KNIHESVSAQI 230 240 250 260 270 280 380 390 400 410 420 pF1KE0 LKRASSRCQSTKSAQSTRSSRSTRSNKSRRVRERELRELNLRYQQQYNG : XP_011 RKNFAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQKDCLAPSTLCSFI 290 300 310 320 330 340 >>XP_016884766 (OMIM: 300680) PREDICTED: calcium/calmodu (426 aa) initn: 766 init1: 413 opt: 866 Z-score: 420.0 bits: 86.8 E(85289): 1.2e-16 Smith-Waterman score: 866; 42.4% identity (69.1% similar) in 356 aa overlap (46-399:50-394) 20 30 40 50 60 70 pF1KE0 VQLDLVKKVEPFSGTKSDVYKHFITEVDSVGPVKAGFPAASQYAHPCPGPPTAGHTEPPS :: :: : . :. : .: . :: XP_016 GRDWKAESLADLWPKSSPGDSHRWCKGPGAGP--AG-PQLREAARASSG--LGGGGRHPS 20 30 40 50 60 70 80 90 100 110 120 130 pF1KE0 EPPRRA-RVAKYRAKFDPRVTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYR . : : . : ... :.:. .: :.::.:: ...:.. . :.: : : XP_016 RIPAIALQDMLLLKKHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKAL 80 90 100 110 120 130 140 150 160 170 180 190 pF1KE0 EGRE-VCESELRVLRRVRHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTER .:.: . :.:. ::::. : ::. : .: :. ..:..:::.:::::::::. .::.::. XP_016 RGKEALVENEIAVLRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEK 140 150 160 170 180 190 200 210 220 230 240 250 pF1KE0 DATRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCL ::.... .:: .: :::.:::.::::::::::: : ::::...:::: : . :. . XP_016 DASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGL-SKIQAGN--M 200 210 220 230 240 250 260 270 280 290 300 310 pF1KE0 MKTTCGTPEYIAPEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGK . :.:::: :.:::.: .::: ..::.::::::.:::: : :: :.. .:. ::::.. XP_016 LGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRAS 260 270 280 290 300 310 320 330 340 350 360 370 pF1KE0 YSYSGEPWPSVSNLAKDFIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQ : ... : ..:. ::::: .:: :: :.: ::::: :. . .: . ... :.:. XP_016 YEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALRHLWISGDTAFD--RDILGSVSE 320 330 340 350 360 380 390 400 410 420 pF1KE0 NLLKRASSRCQSTKSAQSTRSSRSTRSNKSRRVRERELRELNLRYQQQYNG .. .. .: . .. ..: : : XP_016 QI-RKNFARTHWKRAFNATSFLRHIRKLGQIPEGEGASEQGMARHSHSGLRAGQPPKW 370 380 390 400 410 420 424 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 03:03:08 2016 done: Sat Nov 5 03:03:10 2016 Total Scan time: 9.940 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]