FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0749, 326 aa 1>>>pF1KE0749 326 - 326 aa - 326 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 13.3751+/-0.000524; mu= -26.4202+/- 0.031 mean_var=689.3934+/-154.246, 0's: 0 Z-trim(117.2): 800 B-trim: 0 in 0/57 Lambda= 0.048847 statistics sampled from 27804 (28928) to 27804 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.705), E-opt: 0.2 (0.339), width: 16 Scan time: 7.620 The best scores are: opt bits E(85289) NP_001001852 (OMIM: 610580) serine/threonine-prote ( 326) 2224 172.2 1.3e-42 NP_002639 (OMIM: 164960) serine/threonine-protein ( 313) 1491 120.6 4.5e-27 NP_001230115 (OMIM: 164960) serine/threonine-prote ( 404) 1491 120.7 5.3e-27 NP_006866 (OMIM: 300295) serine/threonine-protein ( 311) 1197 99.8 7.7e-21 NP_115806 (OMIM: 609235) serine/threonine-protein ( 778) 527 53.1 2.3e-06 NP_003948 (OMIM: 609236) serine/threonine-protein ( 668) 476 49.4 2.5e-05 NP_001243558 (OMIM: 609236) serine/threonine-prote ( 674) 476 49.4 2.5e-05 XP_005253275 (OMIM: 609236) PREDICTED: serine/thre ( 720) 476 49.4 2.6e-05 NP_001243556 (OMIM: 609236) serine/threonine-prote ( 736) 476 49.4 2.7e-05 XP_006718437 (OMIM: 609236) PREDICTED: serine/thre ( 758) 476 49.5 2.7e-05 XP_016874025 (OMIM: 609236) PREDICTED: serine/thre ( 858) 476 49.5 2.9e-05 XP_016874022 (OMIM: 609236) PREDICTED: serine/thre ( 880) 476 49.5 3e-05 NP_055655 (OMIM: 608130) NUAK family SNF1-like kin ( 661) 468 48.8 3.7e-05 XP_005247048 (OMIM: 607505) PREDICTED: PAS domain- (1107) 471 49.3 4.4e-05 XP_011509134 (OMIM: 607505) PREDICTED: PAS domain- (1137) 471 49.3 4.5e-05 NP_001239051 (OMIM: 607505) PAS domain-containing (1288) 471 49.4 4.9e-05 XP_016859124 (OMIM: 607505) PREDICTED: PAS domain- (1323) 471 49.4 5e-05 NP_055963 (OMIM: 607505) PAS domain-containing ser (1323) 471 49.4 5e-05 XP_016859125 (OMIM: 607505) PREDICTED: PAS domain- (1323) 471 49.4 5e-05 NP_001239049 (OMIM: 607505) PAS domain-containing (1323) 471 49.4 5e-05 XP_016859123 (OMIM: 607505) PREDICTED: PAS domain- (1414) 471 49.4 5.2e-05 NP_112214 (OMIM: 608131) NUAK family SNF1-like kin ( 672) 461 48.3 5.2e-05 NP_056006 (OMIM: 608973) serine/threonine-protein ( 926) 465 48.8 5.3e-05 XP_005265302 (OMIM: 612760) PREDICTED: SNF-related ( 765) 460 48.3 6e-05 NP_060189 (OMIM: 612760) SNF-related serine/threon ( 765) 460 48.3 6e-05 NP_001094064 (OMIM: 612760) SNF-related serine/thr ( 765) 460 48.3 6e-05 XP_011516388 (OMIM: 607025) PREDICTED: maternal em ( 373) 446 47.0 7.4e-05 NP_001243559 (OMIM: 609236) serine/threonine-prote ( 766) 451 47.7 9.3e-05 XP_011527776 (OMIM: 605705,616341) PREDICTED: seri ( 734) 450 47.6 9.5e-05 NP_775490 (OMIM: 605705,616341) serine/threonine-p ( 783) 450 47.6 9.9e-05 XP_005259384 (OMIM: 609235) PREDICTED: serine/thre ( 688) 448 47.4 0.0001 XP_011509137 (OMIM: 607505) PREDICTED: PAS domain- ( 873) 451 47.8 0.0001 NP_001243614 (OMIM: 607025) maternal embryonic leu ( 610) 446 47.2 0.0001 XP_011516382 (OMIM: 607025) PREDICTED: maternal em ( 622) 446 47.3 0.0001 XP_011509136 (OMIM: 607505) PREDICTED: PAS domain- ( 944) 451 47.8 0.00011 NP_055606 (OMIM: 607025) maternal embryonic leucin ( 651) 446 47.3 0.00011 XP_011516380 (OMIM: 607025) PREDICTED: maternal em ( 651) 446 47.3 0.00011 XP_011516378 (OMIM: 607025) PREDICTED: maternal em ( 651) 446 47.3 0.00011 XP_011516379 (OMIM: 607025) PREDICTED: maternal em ( 651) 446 47.3 0.00011 XP_011516381 (OMIM: 607025) PREDICTED: maternal em ( 651) 446 47.3 0.00011 XP_011509135 (OMIM: 607505) PREDICTED: PAS domain- (1114) 451 47.9 0.00012 XP_011509133 (OMIM: 607505) PREDICTED: PAS domain- (1144) 451 47.9 0.00012 XP_011509131 (OMIM: 607505) PREDICTED: PAS domain- (1330) 451 48.0 0.00013 XP_011509132 (OMIM: 607505) PREDICTED: PAS domain- (1330) 451 48.0 0.00013 XP_011509130 (OMIM: 607505) PREDICTED: PAS domain- (1330) 451 48.0 0.00013 NP_001239048 (OMIM: 607505) PAS domain-containing (1330) 451 48.0 0.00013 NP_113605 (OMIM: 606495) MAP/microtubule affinity- ( 688) 442 47.0 0.00013 XP_011509128 (OMIM: 607505) PREDICTED: PAS domain- (1355) 451 48.0 0.00013 NP_001186796 (OMIM: 606495) MAP/microtubule affini ( 752) 442 47.1 0.00014 NP_001156769 (OMIM: 600526) serine/threonine-prote ( 709) 441 47.0 0.00014 >>NP_001001852 (OMIM: 610580) serine/threonine-protein k (326 aa) initn: 2224 init1: 2224 opt: 2224 Z-score: 886.0 bits: 172.2 E(85289): 1.3e-42 Smith-Waterman score: 2224; 100.0% identity (100.0% similar) in 326 aa overlap (1-326:1-326) 10 20 30 40 50 60 pF1KE0 MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 ADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 LVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 RSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 GDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGV 250 260 270 280 290 300 310 320 pF1KE0 PESCDLRLCTLDPDDVASTTSSSESL :::::::::::::::::::::::::: NP_001 PESCDLRLCTLDPDDVASTTSSSESL 310 320 >>NP_002639 (OMIM: 164960) serine/threonine-protein kina (313 aa) initn: 1421 init1: 1155 opt: 1491 Z-score: 607.1 bits: 120.6 E(85289): 4.5e-27 Smith-Waterman score: 1491; 69.5% identity (87.3% similar) in 315 aa overlap (1-313:1-309) 10 20 30 40 50 60 pF1KE0 MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRI :::::..::::: . : .: : :.: .:: .:. :::: .:::::::.::.: :. NP_002 MLLSKINSLAHLRAAPCNDLHATK-LAPGK-EKEPLESQYQVGPLLGSGGFGSVYSGIRV 10 20 30 40 50 70 80 90 100 110 pF1KE0 ADGLPVAVKHVVKERVTEWGSL-GGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGF .:.::::.::: :.:...:: : .:. ::.:::::.::.. : :::::::::::::.: NP_002 SDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSS--GFSGVIRLLDWFERPDSF 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 LLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVD .:.::::::.:::::::::::::.: ::: :: ::: ::::::.:::.::::::::.:.: NP_002 VLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILID 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 LRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMV : ::::::::::::::::::::::::::::::::::::::::::::.:::::.:::::: NP_002 LNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMV 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE0 CGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGG :::::::.::::.::...::.::: :::.::::::.::::.::....: :::: : NP_002 CGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM--QDVL 240 250 260 270 280 290 300 310 320 pF1KE0 VP-ESCDLRLCTLDPDDVASTTSSSESL .: :. ...: .:.: NP_002 LPQETAEIHLHSLSPGPSK 300 310 >>NP_001230115 (OMIM: 164960) serine/threonine-protein k (404 aa) initn: 1421 init1: 1155 opt: 1491 Z-score: 605.8 bits: 120.7 E(85289): 5.3e-27 Smith-Waterman score: 1491; 69.5% identity (87.3% similar) in 315 aa overlap (1-313:92-400) 10 20 30 pF1KE0 MLLSKFGSLAHLCGPGGVDHLPVKILQPAK :::::..::::: . : .: : :.: NP_001 PRHSLRHSPGSGSCGSSSGHRPCADILEVGMLLSKINSLAHLRAAPCNDLHATK-LAPGK 70 80 90 100 110 120 40 50 60 70 80 pF1KE0 ADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSL-GGATVPL .:: .:. :::: .:::::::.::.: :..:.::::.::: :.:...:: : .:. ::. NP_001 -EKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 130 140 150 160 170 90 100 110 120 130 140 pF1KE0 EVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARR :::::.::.. : :::::::::::::.:.:.::::::.:::::::::::::.: ::: NP_001 EVVLLKKVSS--GFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARS 180 190 200 210 220 230 150 160 170 180 190 200 pF1KE0 FFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRV :: ::: ::::::.:::.::::::::.:.:: ::::::::::::::::::::::::::: NP_001 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV 240 250 260 270 280 290 210 220 230 240 250 260 pF1KE0 YSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQL :::::::::::::::::.:::::.:::::::::::::.::::.::...::.::: :::.: NP_001 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHL 300 310 320 330 340 350 270 280 290 300 310 320 pF1KE0 IRWCLSLRPSERPSLDQIAAHPWMLGADGGVP-ESCDLRLCTLDPDDVASTTSSSESL :::::.::::.::....: :::: : .: :. ...: .:.: NP_001 IRWCLALRPSDRPTFEEIQNHPWM--QDVLLPQETAEIHLHSLSPGPSK 360 370 380 390 400 >>NP_006866 (OMIM: 300295) serine/threonine-protein kina (311 aa) initn: 1013 init1: 1013 opt: 1197 Z-score: 495.1 bits: 99.8 E(85289): 7.7e-21 Smith-Waterman score: 1197; 61.9% identity (78.0% similar) in 291 aa overlap (12-301:6-294) 10 20 30 40 50 60 pF1KE0 MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRI : :: . :. :. :.:.:: :..: .::.::::::.:: :. NP_006 MLTKPLQGPPAPPGTPTP--PPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRL 10 20 30 40 50 70 80 90 100 110 pF1KE0 ADGLPVAVKHVVKERVTEWGSLGGA-TVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGF .: : ::.: . ..:: :. :. . : ::::.:: ::::.:: :::::::::: .:: NP_006 TDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGF 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 LLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVD .:::::: :::::::.:::.: : : .: ::.::.::..:::: :::::::::::.:.: NP_006 MLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILID 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 LRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMV :: : :::::::::::.: :::::::::::::::: :.::. :::::::.:::::: NP_006 LRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMV 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE0 CGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGG :::::::.:.:::...: : .:::.: ::: ::. .:: ::::..: ::: NP_006 CGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAED 240 250 260 270 280 290 300 310 320 pF1KE0 VPESCDLRLCTLDPDDVASTTSSSESL :: NP_006 VPLNPSKGGPAPLAWSLLP 300 310 >>NP_115806 (OMIM: 609235) serine/threonine-protein kina (778 aa) initn: 406 init1: 279 opt: 527 Z-score: 235.3 bits: 53.1 E(85289): 2.3e-06 Smith-Waterman score: 532; 33.3% identity (61.0% similar) in 300 aa overlap (14-304:8-295) 10 20 30 40 50 pF1KE0 MLLSKFGSLAHLCGPGGVD--HLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGS : :: ::: .: .. .. :.. .::.: : : : NP_115 MSSGAKEGGGGSPAYHLPHP--HPHPPQHAQYVGPYRLEKTLGKGQTGLVKLGV 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 RIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDG . : ::.: : .:...: . : : :...:. . :..: : .: NP_115 HCITGQKVAIKIVNREKLSE-SVL--MKVEREIAILKLIEHPH----VLKLHDVYENKKY 60 70 80 90 100 120 130 140 150 160 170 pF1KE0 FLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLV . ::::. .. :::.....: : ::.:: :...:. ::: .. :::.: ::::. NP_115 LYLVLEHVSGGE-LFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLL 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE0 DLRSGELKLIDFGSGAL-LKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYD : ... ... ::: ..: . :.. :. :. :: :. ..: :: : .:: ::.:. NP_115 DEKNN-IRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFA 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE0 MVCGDIPFEQD------EEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHP .. : .::..: :.. :: . . . . :.::.:.: . ..: .: ::.:: :: NP_115 LLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQKHP 230 240 250 260 270 280 300 310 320 pF1KE0 WMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL :.::. :. : NP_115 WYLGGKHE-PDPCLEPAPGRRVAMRSLPSNGELDPDVLESMASLGCFRDRERLHRELRSE 290 300 310 320 330 340 >>NP_003948 (OMIM: 609236) serine/threonine-protein kina (668 aa) initn: 289 init1: 289 opt: 476 Z-score: 216.6 bits: 49.4 E(85289): 2.5e-05 Smith-Waterman score: 487; 30.8% identity (60.7% similar) in 308 aa overlap (31-321:10-308) 10 20 30 40 50 60 pF1KE0 MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRI :.. .. :.. .::.: : : : . NP_003 MTSTGKDGGAQHAQYVGPYRLEKTLGKGQTGLVKLGVHC 10 20 30 70 80 90 100 110 120 pF1KE0 ADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFL . ::.: : .:...: . : :...:. . :..: : .: . NP_003 VTCQKVAIKIVNREKLSESVLM---KVEREIAILKLIEHPH----VLKLHDVYENKKYLY 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE0 LVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDL ::::. .. :::.....: : ::.:: :...:. ::: .. :::.: ::::.: NP_003 LVLEHVSGGE-LFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDE 100 110 120 130 140 150 190 200 210 220 230 pF1KE0 RSGELKLIDFGSGAL-LKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMV ... ... ::: ..: . :.. :. :. :: :: ..: ::.: ::: ::.:. .. NP_003 KNN-IRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFALL 160 170 180 190 200 210 240 250 260 270 280 290 pF1KE0 CGDIPFEQD------EEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWM : .::..: :.. :: . . . . :.::.:.: . . ..: .:..: : :. NP_003 VGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIWY 220 230 240 250 260 270 300 310 320 pF1KE0 LGA------DGGVPESCDLR----LCTLDPDDVASTTSSSESL .:. . .:.. ..: : .::: . : : NP_003 IGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSLGCFRDRNKLLQDLLSEEENQE 280 290 300 310 320 330 NP_003 KMIYFLLLDRKERYPSQEDEDLPPRNEIDPPRKRVDSPMLNRHGKRRPERKSMEVLSVTD 340 350 360 370 380 390 >>NP_001243558 (OMIM: 609236) serine/threonine-protein k (674 aa) initn: 289 init1: 289 opt: 476 Z-score: 216.6 bits: 49.4 E(85289): 2.5e-05 Smith-Waterman score: 487; 30.8% identity (60.7% similar) in 308 aa overlap (31-321:10-308) 10 20 30 40 50 60 pF1KE0 MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRI :.. .. :.. .::.: : : : . NP_001 MTSTGKDGGAQHAQYVGPYRLEKTLGKGQTGLVKLGVHC 10 20 30 70 80 90 100 110 120 pF1KE0 ADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFL . ::.: : .:...: . : :...:. . :..: : .: . NP_001 VTCQKVAIKIVNREKLSESVLM---KVEREIAILKLIEHPH----VLKLHDVYENKKYLY 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE0 LVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDL ::::. .. :::.....: : ::.:: :...:. ::: .. :::.: ::::.: NP_001 LVLEHVSGGE-LFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDE 100 110 120 130 140 150 190 200 210 220 230 pF1KE0 RSGELKLIDFGSGAL-LKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMV ... ... ::: ..: . :.. :. :. :: :: ..: ::.: ::: ::.:. .. NP_001 KNN-IRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFALL 160 170 180 190 200 210 240 250 260 270 280 290 pF1KE0 CGDIPFEQD------EEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWM : .::..: :.. :: . . . . :.::.:.: . . ..: .:..: : :. NP_001 VGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIWY 220 230 240 250 260 270 300 310 320 pF1KE0 LGA------DGGVPESCDLR----LCTLDPDDVASTTSSSESL .:. . .:.. ..: : .::: . : : NP_001 IGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSLGCFRDRNKLLQDLLSEEENQE 280 290 300 310 320 330 NP_001 KMIYFLLLDRKERYPSQEDEDLPPRNEIDPPRKRVDSPMLNRHGKRRPERKSMEVLSVTD 340 350 360 370 380 390 >>XP_005253275 (OMIM: 609236) PREDICTED: serine/threonin (720 aa) initn: 289 init1: 289 opt: 476 Z-score: 216.3 bits: 49.4 E(85289): 2.6e-05 Smith-Waterman score: 487; 30.8% identity (60.7% similar) in 308 aa overlap (31-321:10-308) 10 20 30 40 50 60 pF1KE0 MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRI :.. .. :.. .::.: : : : . XP_005 MTSTGKDGGAQHAQYVGPYRLEKTLGKGQTGLVKLGVHC 10 20 30 70 80 90 100 110 120 pF1KE0 ADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFL . ::.: : .:...: . : :...:. . :..: : .: . XP_005 VTCQKVAIKIVNREKLSESVLM---KVEREIAILKLIEHPH----VLKLHDVYENKKYLY 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE0 LVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDL ::::. .. :::.....: : ::.:: :...:. ::: .. :::.: ::::.: XP_005 LVLEHVSGGE-LFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDE 100 110 120 130 140 150 190 200 210 220 230 pF1KE0 RSGELKLIDFGSGAL-LKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMV ... ... ::: ..: . :.. :. :. :: :: ..: ::.: ::: ::.:. .. XP_005 KNN-IRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFALL 160 170 180 190 200 210 240 250 260 270 280 290 pF1KE0 CGDIPFEQD------EEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWM : .::..: :.. :: . . . . :.::.:.: . . ..: .:..: : :. XP_005 VGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIWY 220 230 240 250 260 270 300 310 320 pF1KE0 LGA------DGGVPESCDLR----LCTLDPDDVASTTSSSESL .:. . .:.. ..: : .::: . : : XP_005 IGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSLGCFRDRNKLLQDLLSEEENQE 280 290 300 310 320 330 XP_005 KMIYFLLLDRKERYPSQEDEDLPPRNEIDPPRKRVDSPMLNRHGKRRPERKSMEVLSVTD 340 350 360 370 380 390 >>NP_001243556 (OMIM: 609236) serine/threonine-protein k (736 aa) initn: 289 init1: 289 opt: 476 Z-score: 216.2 bits: 49.4 E(85289): 2.7e-05 Smith-Waterman score: 487; 30.8% identity (60.7% similar) in 308 aa overlap (31-321:10-308) 10 20 30 40 50 60 pF1KE0 MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRI :.. .. :.. .::.: : : : . NP_001 MTSTGKDGGAQHAQYVGPYRLEKTLGKGQTGLVKLGVHC 10 20 30 70 80 90 100 110 120 pF1KE0 ADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFL . ::.: : .:...: . : :...:. . :..: : .: . NP_001 VTCQKVAIKIVNREKLSESVLM---KVEREIAILKLIEHPH----VLKLHDVYENKKYLY 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE0 LVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDL ::::. .. :::.....: : ::.:: :...:. ::: .. :::.: ::::.: NP_001 LVLEHVSGGE-LFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDE 100 110 120 130 140 150 190 200 210 220 230 pF1KE0 RSGELKLIDFGSGAL-LKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMV ... ... ::: ..: . :.. :. :. :: :: ..: ::.: ::: ::.:. .. NP_001 KNN-IRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFALL 160 170 180 190 200 210 240 250 260 270 280 290 pF1KE0 CGDIPFEQD------EEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWM : .::..: :.. :: . . . . :.::.:.: . . ..: .:..: : :. NP_001 VGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIWY 220 230 240 250 260 270 300 310 320 pF1KE0 LGA------DGGVPESCDLR----LCTLDPDDVASTTSSSESL .:. . .:.. ..: : .::: . : : NP_001 IGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSLGCFRDRNKLLQDLLSEEENQE 280 290 300 310 320 330 NP_001 KMIYFLLLDRKERYPSQEDEDLPPRNEIDPPRKRVDSPMLNRHGKRRPERKSMEVLSVTD 340 350 360 370 380 390 >>XP_006718437 (OMIM: 609236) PREDICTED: serine/threonin (758 aa) initn: 313 init1: 289 opt: 476 Z-score: 216.0 bits: 49.5 E(85289): 2.7e-05 Smith-Waterman score: 487; 30.8% identity (60.7% similar) in 308 aa overlap (31-321:10-308) 10 20 30 40 50 60 pF1KE0 MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRI :.. .. :.. .::.: : : : . XP_006 MTSTGKDGGAQHAQYVGPYRLEKTLGKGQTGLVKLGVHC 10 20 30 70 80 90 100 110 120 pF1KE0 ADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFL . ::.: : .:...: . : :...:. . :..: : .: . XP_006 VTCQKVAIKIVNREKLSESVLM---KVEREIAILKLIEHPH----VLKLHDVYENKKYLY 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE0 LVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDL ::::. .. :::.....: : ::.:: :...:. ::: .. :::.: ::::.: XP_006 LVLEHVSGGE-LFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDE 100 110 120 130 140 150 190 200 210 220 230 pF1KE0 RSGELKLIDFGSGAL-LKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMV ... ... ::: ..: . :.. :. :. :: :: ..: ::.: ::: ::.:. .. XP_006 KNN-IRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFALL 160 170 180 190 200 210 240 250 260 270 280 290 pF1KE0 CGDIPFEQD------EEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWM : .::..: :.. :: . . . . :.::.:.: . . ..: .:..: : :. XP_006 VGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIWY 220 230 240 250 260 270 300 310 320 pF1KE0 LGA------DGGVPESCDLR----LCTLDPDDVASTTSSSESL .:. . .:.. ..: : .::: . : : XP_006 IGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSLGCFRDRNKLLQDLLSEEENQE 280 290 300 310 320 330 XP_006 KMIYFLLLDRKERYPSQEDEDLPPRNEIDPPRKRVDSPMLNRHGKRRPERKSMEVLSVTD 340 350 360 370 380 390 326 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 03:03:45 2016 done: Sat Nov 5 03:03:47 2016 Total Scan time: 7.620 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]