Result of FASTA (omim) for
pF1KE0782
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0782, 453 aa
1>>>pF1KE0782 453 - 453 aa - 453 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.3430+/-0.000386; mu= 13.9828+/- 0.024
mean_var=138.3006+/-25.959, 0's: 0 Z-trim(117.6): 76 B-trim: 184 in 1/52
Lambda= 0.109059
statistics sampled from 29604 (29685) to 29604 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.706), E-opt: 0.2 (0.348), width: 16
Scan time: 9.920
The best scores are: opt bits E(85289)
NP_444272 (OMIM: 608785) serine protease HTRA3 iso ( 453) 3035 489.2 9.4e-138
NP_001284488 (OMIM: 608785) serine protease HTRA3 ( 357) 2367 384.0 3.5e-106
XP_011511898 (OMIM: 608785) PREDICTED: serine prot ( 373) 2367 384.0 3.6e-106
NP_002766 (OMIM: 600142,602194,610149,616779) seri ( 480) 1547 255.1 2.9e-67
NP_710159 (OMIM: 610700) serine protease HTRA4 pre ( 476) 1468 242.7 1.6e-63
XP_011542733 (OMIM: 610700) PREDICTED: serine prot ( 380) 1209 201.8 2.5e-51
NP_037379 (OMIM: 606441,610297) serine protease HT ( 458) 1133 190.0 1.2e-47
XP_011542734 (OMIM: 610700) PREDICTED: serine prot ( 343) 1028 173.3 8.9e-43
NP_001308657 (OMIM: 606441,610297) serine protease ( 426) 920 156.4 1.3e-37
NP_001308656 (OMIM: 606441,610297) serine protease ( 436) 727 126.1 1.9e-28
NP_659540 (OMIM: 606441,610297) serine protease HT ( 361) 377 70.9 6.3e-12
NP_001545 (OMIM: 602369) protein CYR61 precursor [ ( 381) 199 42.9 0.0018
NP_008967 (OMIM: 601521) endothelial cell-specific ( 184) 189 41.0 0.0032
NP_001240764 (OMIM: 602867,614224) insulin-like gr ( 279) 191 41.5 0.0034
NP_001544 (OMIM: 602867,614224) insulin-like growt ( 282) 191 41.5 0.0034
XP_016859749 (OMIM: 606189) PREDICTED: cysteine-ri ( 955) 197 43.0 0.0041
XP_016859748 (OMIM: 606189) PREDICTED: cysteine-ri ( 971) 197 43.0 0.0042
XP_005264414 (OMIM: 606189) PREDICTED: cysteine-ri ( 978) 197 43.0 0.0042
XP_016859747 (OMIM: 606189) PREDICTED: cysteine-ri ( 996) 197 43.0 0.0042
XP_011531203 (OMIM: 606189) PREDICTED: cysteine-ri (1003) 197 43.0 0.0043
XP_011531201 (OMIM: 606189) PREDICTED: cysteine-ri (1012) 197 43.1 0.0043
NP_057525 (OMIM: 606189) cysteine-rich motor neuro (1036) 197 43.1 0.0044
XP_011531200 (OMIM: 606189) PREDICTED: cysteine-ri (1077) 197 43.1 0.0045
NP_001129076 (OMIM: 601521) endothelial cell-speci ( 134) 181 39.6 0.0061
>>NP_444272 (OMIM: 608785) serine protease HTRA3 isoform (453 aa)
initn: 3035 init1: 3035 opt: 3035 Z-score: 2594.1 bits: 489.2 E(85289): 9.4e-138
Smith-Waterman score: 3035; 100.0% identity (100.0% similar) in 453 aa overlap (1-453:1-453)
10 20 30 40 50 60
pF1KE0 MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_444 MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 PCGGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_444 PCGGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 LQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_444 LQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 SEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_444 SEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 VLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_444 VLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAII
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 NYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_444 NYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 MRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_444 MRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSS
370 380 390 400 410 420
430 440 450
pF1KE0 ELQEAVLTESPLLLEVRRGNDDLLFSIAPEVVM
:::::::::::::::::::::::::::::::::
NP_444 ELQEAVLTESPLLLEVRRGNDDLLFSIAPEVVM
430 440 450
>>NP_001284488 (OMIM: 608785) serine protease HTRA3 isof (357 aa)
initn: 2367 init1: 2367 opt: 2367 Z-score: 2027.4 bits: 384.0 E(85289): 3.5e-106
Smith-Waterman score: 2367; 100.0% identity (100.0% similar) in 350 aa overlap (1-350:1-350)
10 20 30 40 50 60
pF1KE0 MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 PCGGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PCGGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 LQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 SEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 VLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAII
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 NYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIR
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKAPSLAVH
310 320 330 340 350
370 380 390 400 410 420
pF1KE0 MRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSS
>>XP_011511898 (OMIM: 608785) PREDICTED: serine protease (373 aa)
initn: 2367 init1: 2367 opt: 2367 Z-score: 2027.1 bits: 384.0 E(85289): 3.6e-106
Smith-Waterman score: 2367; 100.0% identity (100.0% similar) in 350 aa overlap (1-350:1-350)
10 20 30 40 50 60
pF1KE0 MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 PCGGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PCGGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 LQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 SEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 VLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAII
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 NYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIR
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKAKHMDPSAAK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 MRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSS
XP_011 AGAMRAGHMKSCC
370
>>NP_002766 (OMIM: 600142,602194,610149,616779) serine p (480 aa)
initn: 1739 init1: 753 opt: 1547 Z-score: 1328.5 bits: 255.1 E(85289): 2.9e-67
Smith-Waterman score: 1716; 57.4% identity (78.0% similar) in 472 aa overlap (6-452:14-478)
10 20 30 40
pF1KE0 MQARALLLAALAALALARE----PPAAPCPARCDVSRCP-SPR-CPGGYVPD
::::: :. :.: : :: :: ::. .::: .:. : :: . :
NP_002 MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARD
10 20 30 40 50 60
50 60 70 80 90
pF1KE0 LCNCCLVCAASEGEPCGGPLDSPCGESLECV----------------RGLCRCRWSHAVC
:.:: ::.: :: :: ..::::.:.:: ::: : :. ::
NP_002 ACGCCEVCGAPEGAACGLQ-EGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVC
70 80 90 100 110
100 110 120 130 140 150
pF1KE0 GTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKI
:.:..::::.: :.:::::. .: :: ::.::: : .. .: :.:.::::::::::
NP_002 GSDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKI
120 130 140 150 160 170
160 170 180 190 200 210
pF1KE0 APAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQ
:::::::::: . :. :.::..::::::.:: :::.::::::.. ....::.:.
NP_002 APAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTN------KHRVKVELK
180 190 200 210 220 230
220 230 240 250 260 270
pF1KE0 NGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVT
:: .::: :::.:.:.::: ::: . ::::::::.:..::::::::::::::.::::::
NP_002 NGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVT
240 250 260 270 280 290
280 290 300 310 320 330
pF1KE0 TGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISF
::::::.:: :.:::::.::::::::::::::::::::::::::::::::::::::::::
NP_002 TGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISF
300 310 320 330 340 350
340 350 360 370 380
pF1KE0 AIPSDRITRFLTEFQDKQIKDW---KKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIY
:::::.: .:::: .:.: : ::..::::: ..: : . ::: . :::.: :: :
NP_002 AIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAY
360 370 380 390 400 410
390 400 410 420 430 440
pF1KE0 VQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEVRRGNDDLLFSI
. :: :..:.. ::....:.:...::. .:......... :: : . :::::.:.....
NP_002 IIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITV
420 430 440 450 460 470
450
pF1KE0 APEVVM
:: .
NP_002 IPEEIDP
480
>>NP_710159 (OMIM: 610700) serine protease HTRA4 precurs (476 aa)
initn: 1374 init1: 674 opt: 1468 Z-score: 1261.4 bits: 242.7 E(85289): 1.6e-63
Smith-Waterman score: 1468; 50.3% identity (75.4% similar) in 463 aa overlap (6-452:20-475)
10 20 30 40
pF1KE0 MQARALLLAALAALALAREPPAAP-CPARCDVSRCPS-PRCPGGYV
::: . . : :.. . : ::: :. .:::. : : : .
NP_710 MIRPQLRTAGLGRCLLPGLLLLLVPVLWAGAEKLHTQPSCPAVCQPTRCPALPTCALGTT
10 20 30 40 50 60
50 60 70 80 90
pF1KE0 P--DLCNCCLVCAASEGEPCGGPLDSPCGESLECVRGL-------CRC-RWSHAVCGTDG
: ::: :: :: :.: : ::: .::. .:.:.. : : : . ::::.:
NP_710 PVFDLCRCCRVCPAAEREVCGGAQGQPCAPGLQCLQPLRPGFPSTCGCPTLGGAVCGSDR
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE0 HTYANVCALQAASRRALQLSGTPVRQLQKGAC-PLGLHQLSSPRYKFNFIADVVEKIAPA
.:: ..:::.: .: : .:. .:. .: : : : .. . : ..:::: ::::.::.
NP_710 RTYPSMCALRAENRAARRLGKVPAVPVQWGNCGDTGTRSAGPLRRNYNFIAAVVEKVAPS
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE0 VVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGD
:::..:. : .: ::. ::::::.:: :::::::::: . .: ..: ::::
NP_710 VVHVQLWGRLLHGSRLVPVYSGSGFIVSEDGLIITNAHVVRN------QQWIEVVLQNGA
190 200 210 220 230
220 230 240 250 260 270
pF1KE0 SYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGI
:::..:::: : :.:.:::. . .::::.::.:.::: ::::::.::::.::::.:.::
NP_710 RYEAVVKDIDLKLDLAVIKIESNAELPVLMLGRSSDLRAGEFVVALGSPFSLQNTATAGI
240 250 260 270 280 290
280 290 300 310 320 330
pF1KE0 VSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIP
::: :: :.:::..::::::.: :: :::::::::::::::.:::.:.:.:: :::::::
NP_710 VSTKQRGGKELGMKDSDMDYVQIDATINYGNSGGPLVNLDGDVIGVNSLRVTDGISFAIP
300 310 320 330 340 350
340 350 360 370 380 390
pF1KE0 SDRITRFLTEFQDKQIKDW---KKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQE
:::. .::.:....:.: .:...:..: ..: : .::: ::::.::::.:: .
NP_710 SDRVRQFLAEYHEHQMKGKAFSNKKYLGLQMLSLTVPLSEELKMHYPDFPDVSSGVYVCK
360 370 380 390 400 410
400 410 420 430 440 450
pF1KE0 VAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEVRRGNDDLLFSIAPE
:. .. .: .:..: :.::..::.:.. .... .:. ..: : . : ::.:.::... ::
NP_710 VVEGTAAQSSGLRDHDVIVNINGKPITTTTDVVKALDSDS-LSMAVLRGKDNLLLTVIPE
420 430 440 450 460 470
pF1KE0 VVM
..
NP_710 TIN
>>XP_011542733 (OMIM: 610700) PREDICTED: serine protease (380 aa)
initn: 1198 init1: 679 opt: 1209 Z-score: 1042.4 bits: 201.8 E(85289): 2.5e-51
Smith-Waterman score: 1209; 54.0% identity (75.1% similar) in 361 aa overlap (6-353:20-374)
10 20 30 40
pF1KE0 MQARALLLAALAALALAREPPAAP-CPARCDVSRCPS-PRCPGGYV
::: . . : :.. . : ::: :. .:::. : : : .
XP_011 MIRPQLRTAGLGRCLLPGLLLLLVPVLWAGAEKLHTQPSCPAVCQPTRCPALPTCALGTT
10 20 30 40 50 60
50 60 70 80 90
pF1KE0 P--DLCNCCLVCAASEGEPCGGPLDSPCGESLECVRGL-------CRC-RWSHAVCGTDG
: ::: :: :: :.: : ::: .::. .:.:.. : : : . ::::.:
XP_011 PVFDLCRCCRVCPAAEREVCGGAQGQPCAPGLQCLQPLRPGFPSTCGCPTLGGAVCGSDR
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE0 HTYANVCALQAASRRALQLSGTPVRQLQKGAC-PLGLHQLSSPRYKFNFIADVVEKIAPA
.:: ..:::.: .: : .:. .:. .: : : : .. . : ..:::: ::::.::.
XP_011 RTYPSMCALRAENRAARRLGKVPAVPVQWGNCGDTGTRSAGPLRRNYNFIAAVVEKVAPS
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE0 VVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGD
:::..:. : .: ::. ::::::.:: :::::::::: . .: ..: ::::
XP_011 VVHVQLWGRLLHGSRLVPVYSGSGFIVSEDGLIITNAHVVRN------QQWIEVVLQNGA
190 200 210 220 230
220 230 240 250 260 270
pF1KE0 SYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGI
:::..:::: : :.:.:::. . .::::.::.:.::: ::::::.::::.::::.:.::
XP_011 RYEAVVKDIDLKLDLAVIKIESNAELPVLMLGRSSDLRAGEFVVALGSPFSLQNTATAGI
240 250 260 270 280 290
280 290 300 310 320 330
pF1KE0 VSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIP
::: :: :.:::..::::::.: :: :::::::::::::::.:::.:.:.:: :::::::
XP_011 VSTKQRGGKELGMKDSDMDYVQIDATINYGNSGGPLVNLDGDVIGVNSLRVTDGISFAIP
300 310 320 330 340 350
340 350 360 370 380 390
pF1KE0 SDRITRFLTEFQDKQIKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAP
:::. .::.:....:.:. :
XP_011 SDRVRQFLAEYHEHQMKEAKTIAAQS
360 370 380
>>NP_037379 (OMIM: 606441,610297) serine protease HTRA2, (458 aa)
initn: 885 init1: 634 opt: 1133 Z-score: 976.7 bits: 190.0 E(85289): 1.2e-47
Smith-Waterman score: 1138; 45.2% identity (71.6% similar) in 454 aa overlap (10-451:19-456)
10 20 30 40 50
pF1KE0 MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGY-VPDLCNC
::... .:.: .: .: .:: : .:.:
NP_037 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSL-WA
10 20 30 40 50
60 70 80 90 100
pF1KE0 CLVCAASEGEPC---GGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAAS
: ...: . : : : .: .. : : : : . :: .... : :: :..
NP_037 RLSVGVTEPRACLTSGTP--GPRAQ-LTAVTPDTRTREASENSGTRSRAWLAV-ALGAGG
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE0 RRALQLSGT---PVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHP
: : : : : : .::: ..::::::::: :::::.::.. :::
NP_037 AVLLLLWGGGRGPPAVLAAVPSP----PPASPRSQYNFIADVVEKTAPAVVYIEILDRHP
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE0 LFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDK
..::.::.:.::::... :::.::::::.. :....:.: .::.:::.. .:
NP_037 FLGREVPISNGSGFVVAADGLIVTNAHVVAD------RRRVRVRLLSGDTYEAVVTAVDP
180 190 200 210 220
230 240 250 260 270 280
pF1KE0 KSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGREL
.::::..:. :. ::.: ::.:::.: ::::::.:::::::::.:.::::.::: .:.:
NP_037 VADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDL
230 240 250 260 270 280
290 300 310 320 330 340
pF1KE0 GLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEF
:: .....:::::: :..::::::::::::::::.::.::::::::::::::. .:: .
NP_037 GLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRG
290 300 310 320 330 340
350 360 370 380 390 400
pF1KE0 QDKQ----IKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRG
. :. :. ..:.::. : :..::.. ::. .:.::.:. :. ...: .::..:.
NP_037 EKKNSSSGISGSQRRYIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRA
350 360 370 380 390 400
410 420 430 440 450
pF1KE0 GIQDGDIIVKVNGRPLVDSSE-LQEAVLTESPLLLEVRRGNDDLLFSIAPEVVM
:.. ::.:. . :. .:...: . ::: :.: : ...::: . : . ..:::
NP_037 GLRPGDVILAI-GEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
410 420 430 440 450
>>XP_011542734 (OMIM: 610700) PREDICTED: serine protease (343 aa)
initn: 1029 init1: 510 opt: 1028 Z-score: 889.0 bits: 173.3 E(85289): 8.9e-43
Smith-Waterman score: 1028; 53.1% identity (72.8% similar) in 320 aa overlap (6-312:20-333)
10 20 30 40
pF1KE0 MQARALLLAALAALALAREPPAAP-CPARCDVSRCPS-PRCPGGYV
::: . . : :.. . : ::: :. .:::. : : : .
XP_011 MIRPQLRTAGLGRCLLPGLLLLLVPVLWAGAEKLHTQPSCPAVCQPTRCPALPTCALGTT
10 20 30 40 50 60
50 60 70 80 90
pF1KE0 P--DLCNCCLVCAASEGEPCGGPLDSPCGESLECVRGL-------CRC-RWSHAVCGTDG
: ::: :: :: :.: : ::: .::. .:.:.. : : : . ::::.:
XP_011 PVFDLCRCCRVCPAAEREVCGGAQGQPCAPGLQCLQPLRPGFPSTCGCPTLGGAVCGSDR
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE0 HTYANVCALQAASRRALQLSGTPVRQLQKGAC-PLGLHQLSSPRYKFNFIADVVEKIAPA
.:: ..:::.: .: : .:. .:. .: : : : .. . : ..:::: ::::.::.
XP_011 RTYPSMCALRAENRAARRLGKVPAVPVQWGNCGDTGTRSAGPLRRNYNFIAAVVEKVAPS
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE0 VVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGD
:::..:. : .: ::. ::::::.:: :::::::::: . .: ..: ::::
XP_011 VVHVQLWGRLLHGSRLVPVYSGSGFIVSEDGLIITNAHVVRN------QQWIEVVLQNGA
190 200 210 220 230
220 230 240 250 260 270
pF1KE0 SYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGI
:::..:::: : :.:.:::. . .::::.::.:.::: ::::::.::::.::::.:.::
XP_011 RYEAVVKDIDLKLDLAVIKIESNAELPVLMLGRSSDLRAGEFVVALGSPFSLQNTATAGI
240 250 260 270 280 290
280 290 300 310 320 330
pF1KE0 VSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIP
::: :: :.:::..::::::.: :: :::::::::::::
XP_011 VSTKQRGGKELGMKDSDMDYVQIDATINYGNSGGPLVNLVFSLDLLTCL
300 310 320 330 340
340 350 360 370 380 390
pF1KE0 SDRITRFLTEFQDKQIKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAP
>>NP_001308657 (OMIM: 606441,610297) serine protease HTR (426 aa)
initn: 752 init1: 635 opt: 920 Z-score: 796.0 bits: 156.4 E(85289): 1.3e-37
Smith-Waterman score: 980; 42.7% identity (66.1% similar) in 454 aa overlap (10-451:19-424)
10 20 30 40 50
pF1KE0 MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGY-VPDLCNC
::... .:.: .: .: .:: : .:.:
NP_001 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSL-WA
10 20 30 40 50
60 70 80 90 100
pF1KE0 CLVCAASEGEPC---GGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAAS
: ...: . : : : .: .. : : : : . :: .... : :: :..
NP_001 RLSVGVTEPRACLTSGTP--GPRAQ-LTAVTPDTRTREASENSGTRSRAWLAV-ALGAGG
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE0 RRALQLSGT---PVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHP
: : : : : : .::: ..::::::::: :::::.::.. :::
NP_001 AVLLLLWGGGRGPPAVLAAVPSP----PPASPRSQYNFIADVVEKTAPAVVYIEILDRHP
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE0 LFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDK
..::.::.:.::::... :::.::::::.. :....:.: .::.:::.. .:
NP_001 FLGREVPISNGSGFVVAADGLIVTNAHVVAD------RRRVRVRLLSGDTYEAVVTAVDP
180 190 200 210 220
230 240 250 260 270 280
pF1KE0 KSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGREL
.::::..:. :. ::.: ::.:::.: ::::::.:::::::::.:.::::.::: .:.:
NP_001 VADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDL
230 240 250 260 270 280
290 300 310 320 330 340
pF1KE0 GLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEF
:: .....:::::: :..::::::::::::::::.::.::::::::::::::. .:: .
NP_001 GLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRG
290 300 310 320 330 340
350 360 370 380 390 400
pF1KE0 QDKQ----IKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRG
. :. :. ..:.::. : :..: :.
NP_001 EKKNSSSGISGSQRRYIGVMMLTLSP--------------------------------RA
350 360 370
410 420 430 440 450
pF1KE0 GIQDGDIIVKVNGRPLVDSSE-LQEAVLTESPLLLEVRRGNDDLLFSIAPEVVM
:.. ::.:. . :. .:...: . ::: :.: : ...::: . : . ..:::
NP_001 GLRPGDVILAI-GEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
380 390 400 410 420
>>NP_001308656 (OMIM: 606441,610297) serine protease HTR (436 aa)
initn: 738 init1: 474 opt: 727 Z-score: 631.7 bits: 126.1 E(85289): 1.9e-28
Smith-Waterman score: 950; 41.8% identity (64.7% similar) in 464 aa overlap (10-451:19-434)
10 20 30 40 50
pF1KE0 MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGY-VPDLCNC
::... .:.: .: .: .:: : .:.:
NP_001 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSL-WA
10 20 30 40 50
60 70 80 90 100
pF1KE0 CLVCAASEGEPC---GGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAAS
: ...: . : : : .: .. : : : : . :: .... : :: :..
NP_001 RLSVGVTEPRACLTSGTP--GPRAQ-LTAVTPDTRTREASENSGTRSRAWLAV-ALGAGG
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE0 RRALQLSGT---PVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHP
: : : : : : .::: ..::::::::: :::::.::.. :::
NP_001 AVLLLLWGGGRGPPAVLAAVPSP----PPASPRSQYNFIADVVEKTAPAVVYIEILDRHP
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE0 LFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDK
..::.::.:.::::... :::.::::::.. :....:.: .::.:::.. .:
NP_001 FLGREVPISNGSGFVVAADGLIVTNAHVVAD------RRRVRVRLLSGDTYEAVVTAVDP
180 190 200 210 220
230 240 250 260 270 280
pF1KE0 KSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGREL
.::::..:. :. ::.: ::.:::.: ::::::.:::::::::.:.::::.::: .:.:
NP_001 VADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDL
230 240 250 260 270 280
290 300 310 320 330
pF1KE0 GLRDSDMDYIQTDAIINYGNSGGPLVNL----------DGEVIGINTLKVTAGISFAIPS
:: .....:::::: :..:::::::::: ::::::.::.::::::::::::
NP_001 GLPQTNVEYIQTDAAIDFGNSGGPLVNLARELGAVSLQDGEVIGVNTMKVTAGISFAIPS
290 300 310 320 330 340
340 350 360 370 380 390
pF1KE0 DRITRFLTEFQDKQ----IKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQE
::. .:: . . :. :. ..:.::. : :..:
NP_001 DRLREFLHRGEKKNSSSGISGSQRRYIGVMMLTLSP------------------------
350 360 370 380
400 410 420 430 440
pF1KE0 VAPNSPSQRGGIQDGDIIVKVNGRPLVDSSE-LQEAVLTESPLLLEVRRGNDDLLFSIAP
:.:.. ::.:. . :. .:...: . ::: :.: : ...::: . : . ..:
NP_001 --------RAGLRPGDVILAI-GEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTP
390 400 410 420 430
450
pF1KE0 EVVM
::
NP_001 EVTE
453 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 03:08:16 2016 done: Sat Nov 5 03:08:18 2016
Total Scan time: 9.920 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]