FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0784, 423 aa 1>>>pF1KE0784 423 - 423 aa - 423 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.7318+/-0.000589; mu= -3.2279+/- 0.035 mean_var=684.6413+/-163.775, 0's: 0 Z-trim(114.8): 123 B-trim: 33 in 1/53 Lambda= 0.049017 statistics sampled from 24818 (24907) to 24818 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.654), E-opt: 0.2 (0.292), width: 16 Scan time: 8.910 The best scores are: opt bits E(85289) NP_001026982 (OMIM: 604253) casein kinase I isofor ( 423) 2887 220.3 7.5e-57 XP_005271952 (OMIM: 604253) PREDICTED: casein kina ( 424) 2875 219.4 1.3e-56 NP_001257501 (OMIM: 604253) casein kinase I isofor ( 424) 2875 219.4 1.3e-56 XP_016864558 (OMIM: 604253) PREDICTED: casein kina ( 424) 2875 219.4 1.3e-56 XP_016864559 (OMIM: 604253) PREDICTED: casein kina ( 415) 2789 213.3 9e-55 XP_005271953 (OMIM: 604253) PREDICTED: casein kina ( 416) 2777 212.5 1.6e-54 XP_016864554 (OMIM: 604253) PREDICTED: casein kina ( 448) 2486 192.0 2.6e-48 XP_016864555 (OMIM: 604253) PREDICTED: casein kina ( 448) 2486 192.0 2.6e-48 XP_016864553 (OMIM: 604253) PREDICTED: casein kina ( 449) 2474 191.1 4.7e-48 XP_005271951 (OMIM: 604253) PREDICTED: casein kina ( 447) 2462 190.3 8.5e-48 NP_004375 (OMIM: 604253) casein kinase I isoform g ( 447) 2462 190.3 8.5e-48 XP_005271949 (OMIM: 604253) PREDICTED: casein kina ( 455) 2462 190.3 8.6e-48 NP_001038188 (OMIM: 604253) casein kinase I isofor ( 455) 2462 190.3 8.6e-48 XP_005271948 (OMIM: 604253) PREDICTED: casein kina ( 456) 2450 189.4 1.6e-47 XP_016864557 (OMIM: 604253) PREDICTED: casein kina ( 440) 2388 185.0 3.2e-46 NP_001257502 (OMIM: 604253) casein kinase I isofor ( 348) 2384 184.6 3.5e-46 XP_016864556 (OMIM: 604253) PREDICTED: casein kina ( 441) 2376 184.2 5.7e-46 NP_001316535 (OMIM: 606274) casein kinase I isofor ( 422) 2296 178.5 2.8e-44 NP_071331 (OMIM: 606274) casein kinase I isoform g ( 422) 2296 178.5 2.8e-44 NP_001310 (OMIM: 602214) casein kinase I isoform g ( 415) 2227 173.6 8.3e-43 NP_001316536 (OMIM: 606274) casein kinase I isofor ( 438) 2221 173.2 1.1e-42 NP_001257503 (OMIM: 604253) casein kinase I isofor ( 311) 2097 164.2 4.2e-40 XP_016864550 (OMIM: 604253) PREDICTED: casein kina ( 480) 2061 162.0 3e-39 XP_016864551 (OMIM: 604253) PREDICTED: casein kina ( 480) 2061 162.0 3e-39 NP_001316534 (OMIM: 606274) casein kinase I isofor ( 475) 2057 161.7 3.7e-39 XP_016864552 (OMIM: 604253) PREDICTED: casein kina ( 473) 2049 161.1 5.4e-39 XP_016864548 (OMIM: 604253) PREDICTED: casein kina ( 481) 2049 161.1 5.5e-39 XP_016864549 (OMIM: 604253) PREDICTED: casein kina ( 481) 2049 161.1 5.5e-39 XP_016864546 (OMIM: 604253) PREDICTED: casein kina ( 481) 2049 161.1 5.5e-39 XP_016864547 (OMIM: 604253) PREDICTED: casein kina ( 481) 2049 161.1 5.5e-39 XP_005259557 (OMIM: 602214) PREDICTED: casein kina ( 440) 2043 160.6 7e-39 XP_016881787 (OMIM: 602214) PREDICTED: casein kina ( 367) 1992 156.9 7.9e-38 XP_005259558 (OMIM: 602214) PREDICTED: casein kina ( 392) 1808 143.9 6.7e-34 XP_016881786 (OMIM: 602214) PREDICTED: casein kina ( 445) 1775 141.7 3.6e-33 XP_005259555 (OMIM: 602214) PREDICTED: casein kina ( 445) 1775 141.7 3.6e-33 XP_005259556 (OMIM: 602214) PREDICTED: casein kina ( 445) 1775 141.7 3.6e-33 NP_689407 (OMIM: 600863) casein kinase I isoform e ( 416) 1225 102.7 1.8e-21 NP_001885 (OMIM: 600863) casein kinase I isoform e ( 416) 1225 102.7 1.8e-21 NP_620693 (OMIM: 600864,615224) casein kinase I is ( 409) 1212 101.8 3.3e-21 NP_001884 (OMIM: 600864,615224) casein kinase I is ( 415) 1212 101.8 3.4e-21 XP_005256394 (OMIM: 600864,615224) PREDICTED: case ( 427) 1212 101.8 3.4e-21 XP_005256393 (OMIM: 600864,615224) PREDICTED: case ( 450) 1212 101.9 3.5e-21 NP_001883 (OMIM: 600505) casein kinase I isoform a ( 337) 1125 95.5 2.2e-19 NP_001258670 (OMIM: 600505) casein kinase I isofor ( 325) 1116 94.8 3.3e-19 XP_016879688 (OMIM: 600864,615224) PREDICTED: case ( 393) 1019 88.1 4.2e-17 NP_001258671 (OMIM: 600505) casein kinase I isofor ( 276) 623 59.9 9.5e-09 NP_001020276 (OMIM: 600505) casein kinase I isofor ( 365) 520 52.8 1.7e-06 NP_775771 (OMIM: 604432,611695) tau-tubulin kinase (1244) 525 54.1 2.4e-06 XP_006720466 (OMIM: 604432,611695) PREDICTED: tau- (1175) 432 47.4 0.00022 XP_005254230 (OMIM: 604432,611695) PREDICTED: tau- (1175) 432 47.4 0.00022 >>NP_001026982 (OMIM: 604253) casein kinase I isoform ga (423 aa) initn: 2887 init1: 2887 opt: 2887 Z-score: 1141.7 bits: 220.3 E(85289): 7.5e-57 Smith-Waterman score: 2887; 100.0% identity (100.0% similar) in 423 aa overlap (1-423:1-423) 10 20 30 40 50 60 pF1KE0 MENKKKDKDKSDDRMARPSGRSGHNTRGTGSSSSGVLMVGPNFRVGKKIGCGNFGELRLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MENKKKDKDKSDDRMARPSGRSGHNTRGTGSSSSGVLMVGPNFRVGKKIGCGNFGELRLG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 KNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 PSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 IHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 YFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 YDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 NQVVSSTNGELNTDDPTAGRSNAPITAPTEVEVMDETNCQKVLNMWCCCFFKRRKRKTIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NQVVSSTNGELNTDDPTAGRSNAPITAPTEVEVMDETNCQKVLNMWCCCFFKRRKRKTIQ 370 380 390 400 410 420 pF1KE0 RHK ::: NP_001 RHK >>XP_005271952 (OMIM: 604253) PREDICTED: casein kinase I (424 aa) initn: 1936 init1: 1903 opt: 2875 Z-score: 1137.1 bits: 219.4 E(85289): 1.3e-56 Smith-Waterman score: 2875; 99.8% identity (99.8% similar) in 424 aa overlap (1-423:1-424) 10 20 30 40 50 60 pF1KE0 MENKKKDKDKSDDRMARPSGRSGHNTRGTGSSSSGVLMVGPNFRVGKKIGCGNFGELRLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MENKKKDKDKSDDRMARPSGRSGHNTRGTGSSSSGVLMVGPNFRVGKKIGCGNFGELRLG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 KNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 PSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 IHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFM 190 200 210 220 230 240 250 260 270 280 290 pF1KE0 YFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPE-MATYLRYVRRLDFFEKP :::::::::::::::::::::::::::::::::::::::::: ::::::::::::::::: XP_005 YFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEEMATYLRYVRRLDFFEKP 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE0 DYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQS 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE0 KNQVVSSTNGELNTDDPTAGRSNAPITAPTEVEVMDETNCQKVLNMWCCCFFKRRKRKTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KNQVVSSTNGELNTDDPTAGRSNAPITAPTEVEVMDETNCQKVLNMWCCCFFKRRKRKTI 370 380 390 400 410 420 420 pF1KE0 QRHK :::: XP_005 QRHK >>NP_001257501 (OMIM: 604253) casein kinase I isoform ga (424 aa) initn: 1936 init1: 1903 opt: 2875 Z-score: 1137.1 bits: 219.4 E(85289): 1.3e-56 Smith-Waterman score: 2875; 99.8% identity (99.8% similar) in 424 aa overlap (1-423:1-424) 10 20 30 40 50 60 pF1KE0 MENKKKDKDKSDDRMARPSGRSGHNTRGTGSSSSGVLMVGPNFRVGKKIGCGNFGELRLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MENKKKDKDKSDDRMARPSGRSGHNTRGTGSSSSGVLMVGPNFRVGKKIGCGNFGELRLG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 KNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 PSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 IHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFM 190 200 210 220 230 240 250 260 270 280 290 pF1KE0 YFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPE-MATYLRYVRRLDFFEKP :::::::::::::::::::::::::::::::::::::::::: ::::::::::::::::: NP_001 YFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEEMATYLRYVRRLDFFEKP 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE0 DYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQS 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE0 KNQVVSSTNGELNTDDPTAGRSNAPITAPTEVEVMDETNCQKVLNMWCCCFFKRRKRKTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KNQVVSSTNGELNTDDPTAGRSNAPITAPTEVEVMDETNCQKVLNMWCCCFFKRRKRKTI 370 380 390 400 410 420 420 pF1KE0 QRHK :::: NP_001 QRHK >>XP_016864558 (OMIM: 604253) PREDICTED: casein kinase I (424 aa) initn: 1936 init1: 1903 opt: 2875 Z-score: 1137.1 bits: 219.4 E(85289): 1.3e-56 Smith-Waterman score: 2875; 99.8% identity (99.8% similar) in 424 aa overlap (1-423:1-424) 10 20 30 40 50 60 pF1KE0 MENKKKDKDKSDDRMARPSGRSGHNTRGTGSSSSGVLMVGPNFRVGKKIGCGNFGELRLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MENKKKDKDKSDDRMARPSGRSGHNTRGTGSSSSGVLMVGPNFRVGKKIGCGNFGELRLG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 KNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 PSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 IHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFM 190 200 210 220 230 240 250 260 270 280 290 pF1KE0 YFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPE-MATYLRYVRRLDFFEKP :::::::::::::::::::::::::::::::::::::::::: ::::::::::::::::: XP_016 YFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEEMATYLRYVRRLDFFEKP 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE0 DYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQS 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE0 KNQVVSSTNGELNTDDPTAGRSNAPITAPTEVEVMDETNCQKVLNMWCCCFFKRRKRKTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KNQVVSSTNGELNTDDPTAGRSNAPITAPTEVEVMDETNCQKVLNMWCCCFFKRRKRKTI 370 380 390 400 410 420 420 pF1KE0 QRHK :::: XP_016 QRHK >>XP_016864559 (OMIM: 604253) PREDICTED: casein kinase I (415 aa) initn: 2785 init1: 2694 opt: 2789 Z-score: 1104.3 bits: 213.3 E(85289): 9e-55 Smith-Waterman score: 2789; 97.9% identity (98.1% similar) in 423 aa overlap (1-423:1-415) 10 20 30 40 50 60 pF1KE0 MENKKKDKDKSDDRMARPSGRSGHNTRGTGSSSSGVLMVGPNFRVGKKIGCGNFGELRLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MENKKKDKDKSDDRMARPSGRSGHNTRGTGSSSSGVLMVGPNFRVGKKIGCGNFGELRLG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 KNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 PSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 IHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 YFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 YDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 NQVVSSTNGELNTDDPTAGRSNAPITAPTEVEVMDETNCQKVLNMWCCCFFKRRKRKTIQ :::::::::::::::::::::::::::::::::::::.: ::::::::::::: XP_016 NQVVSSTNGELNTDDPTAGRSNAPITAPTEVEVMDETKC--------CCFFKRRKRKTIQ 370 380 390 400 410 pF1KE0 RHK ::: XP_016 RHK >>XP_005271953 (OMIM: 604253) PREDICTED: casein kinase I (416 aa) initn: 2806 init1: 1903 opt: 2777 Z-score: 1099.7 bits: 212.5 E(85289): 1.6e-54 Smith-Waterman score: 2777; 97.6% identity (97.9% similar) in 424 aa overlap (1-423:1-416) 10 20 30 40 50 60 pF1KE0 MENKKKDKDKSDDRMARPSGRSGHNTRGTGSSSSGVLMVGPNFRVGKKIGCGNFGELRLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MENKKKDKDKSDDRMARPSGRSGHNTRGTGSSSSGVLMVGPNFRVGKKIGCGNFGELRLG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 KNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 PSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 IHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFM 190 200 210 220 230 240 250 260 270 280 290 pF1KE0 YFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPE-MATYLRYVRRLDFFEKP :::::::::::::::::::::::::::::::::::::::::: ::::::::::::::::: XP_005 YFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEEMATYLRYVRRLDFFEKP 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE0 DYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQS 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE0 KNQVVSSTNGELNTDDPTAGRSNAPITAPTEVEVMDETNCQKVLNMWCCCFFKRRKRKTI ::::::::::::::::::::::::::::::::::::::.: :::::::::::: XP_005 KNQVVSSTNGELNTDDPTAGRSNAPITAPTEVEVMDETKC--------CCFFKRRKRKTI 370 380 390 400 410 420 pF1KE0 QRHK :::: XP_005 QRHK >>XP_016864554 (OMIM: 604253) PREDICTED: casein kinase I (448 aa) initn: 2874 init1: 2486 opt: 2486 Z-score: 988.2 bits: 192.0 E(85289): 2.6e-48 Smith-Waterman score: 2827; 94.4% identity (94.4% similar) in 448 aa overlap (1-423:1-448) 10 20 30 40 50 pF1KE0 MENKKKDKDKSDDRMARPSGRSGHNTRGTGSSSSGVLMVGPNFRVGKKIGCGNFGELRL- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MENKKKDKDKSDDRMARPSGRSGHNTRGTGSSSSGVLMVGPNFRVGKKIGCGNFGELRLD 10 20 30 40 50 60 60 70 80 90 pF1KE0 ------------------------GKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGS :::::::::::::::::::::::::::::::::::: XP_016 QREKPEGCQGTSASLICDFRLCAQGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGS 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE0 GDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHS 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE0 KNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARY 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE0 MSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEV 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE0 LCENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LCENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVG 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE0 AVQQDPALSSNREAHQHRDKMQQSKNQVVSSTNGELNTDDPTAGRSNAPITAPTEVEVMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AVQQDPALSSNREAHQHRDKMQQSKNQVVSSTNGELNTDDPTAGRSNAPITAPTEVEVMD 370 380 390 400 410 420 400 410 420 pF1KE0 ETNCQKVLNMWCCCFFKRRKRKTIQRHK :::::::::::::::::::::::::::: XP_016 ETNCQKVLNMWCCCFFKRRKRKTIQRHK 430 440 >>XP_016864555 (OMIM: 604253) PREDICTED: casein kinase I (448 aa) initn: 2874 init1: 2486 opt: 2486 Z-score: 988.2 bits: 192.0 E(85289): 2.6e-48 Smith-Waterman score: 2827; 94.4% identity (94.4% similar) in 448 aa overlap (1-423:1-448) 10 20 30 40 50 pF1KE0 MENKKKDKDKSDDRMARPSGRSGHNTRGTGSSSSGVLMVGPNFRVGKKIGCGNFGELRL- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MENKKKDKDKSDDRMARPSGRSGHNTRGTGSSSSGVLMVGPNFRVGKKIGCGNFGELRLD 10 20 30 40 50 60 60 70 80 90 pF1KE0 ------------------------GKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGS :::::::::::::::::::::::::::::::::::: XP_016 QREKPEGCQGTSASLICDFRLCAQGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGS 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE0 GDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHS 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE0 KNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARY 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE0 MSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEV 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE0 LCENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LCENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVG 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE0 AVQQDPALSSNREAHQHRDKMQQSKNQVVSSTNGELNTDDPTAGRSNAPITAPTEVEVMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AVQQDPALSSNREAHQHRDKMQQSKNQVVSSTNGELNTDDPTAGRSNAPITAPTEVEVMD 370 380 390 400 410 420 400 410 420 pF1KE0 ETNCQKVLNMWCCCFFKRRKRKTIQRHK :::::::::::::::::::::::::::: XP_016 ETNCQKVLNMWCCCFFKRRKRKTIQRHK 430 440 >>XP_016864553 (OMIM: 604253) PREDICTED: casein kinase I (449 aa) initn: 1890 init1: 1502 opt: 2474 Z-score: 983.6 bits: 191.1 E(85289): 4.7e-48 Smith-Waterman score: 2815; 94.2% identity (94.2% similar) in 449 aa overlap (1-423:1-449) 10 20 30 40 50 pF1KE0 MENKKKDKDKSDDRMARPSGRSGHNTRGTGSSSSGVLMVGPNFRVGKKIGCGNFGELRL- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MENKKKDKDKSDDRMARPSGRSGHNTRGTGSSSSGVLMVGPNFRVGKKIGCGNFGELRLD 10 20 30 40 50 60 60 70 80 90 pF1KE0 ------------------------GKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGS :::::::::::::::::::::::::::::::::::: XP_016 QREKPEGCQGTSASLICDFRLCAQGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGS 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE0 GDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHS 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE0 KNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARY 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE0 MSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEV 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE0 LCENFPE-MATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPV ::::::: :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LCENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPV 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE0 GAVQQDPALSSNREAHQHRDKMQQSKNQVVSSTNGELNTDDPTAGRSNAPITAPTEVEVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GAVQQDPALSSNREAHQHRDKMQQSKNQVVSSTNGELNTDDPTAGRSNAPITAPTEVEVM 370 380 390 400 410 420 400 410 420 pF1KE0 DETNCQKVLNMWCCCFFKRRKRKTIQRHK ::::::::::::::::::::::::::::: XP_016 DETNCQKVLNMWCCCFFKRRKRKTIQRHK 430 440 >>XP_005271951 (OMIM: 604253) PREDICTED: casein kinase I (447 aa) initn: 2720 init1: 2462 opt: 2462 Z-score: 979.1 bits: 190.3 E(85289): 8.5e-48 Smith-Waterman score: 2715; 91.0% identity (91.2% similar) in 455 aa overlap (1-423:1-447) 10 20 30 40 50 60 pF1KE0 MENKKKDKDKSDDRMARPSGRSGHNTRGTGSSSSGVLMVGPNFRVGKKIGCGNFGELRLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MENKKKDKDKSDDRMARPSGRSGHNTRGTGSSSSGVLMVGPNFRVGKKIGCGNFGELRLG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 KNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 PSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 IHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 YFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 YDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSK 310 320 330 340 350 360 370 380 pF1KE0 NQ--------------------------------VVSSTNGELNTDDPTAGRSNAPITAP :: :::::::::::::::::::::::::: XP_005 NQSADHRAAWDSQQANPHHLRAHLAADRHGGSVQVVSSTNGELNTDDPTAGRSNAPITAP 370 380 390 400 410 420 390 400 410 420 pF1KE0 TEVEVMDETNCQKVLNMWCCCFFKRRKRKTIQRHK :::::::::.: :::::::::::::::: XP_005 TEVEVMDETKC--------CCFFKRRKRKTIQRHK 430 440 423 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 20:22:03 2016 done: Sat Nov 5 20:22:04 2016 Total Scan time: 8.910 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]