Result of FASTA (omim) for
pF1KE0786
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0786, 457 aa
1>>>pF1KE0786 457 - 457 aa - 457 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.6112+/-0.000393; mu= -10.6999+/- 0.024
mean_var=344.1788+/-71.790, 0's: 0 Z-trim(123.5): 368 B-trim: 863 in 1/58
Lambda= 0.069132
statistics sampled from 42995 (43371) to 42995 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.8), E-opt: 0.2 (0.509), width: 16
Scan time: 10.930
The best scores are: opt bits E(85289)
NP_005442 (OMIM: 605903) PDZ and LIM domain protei ( 457) 3252 337.8 3.7e-92
NP_976227 (OMIM: 605903) PDZ and LIM domain protei ( 423) 2366 249.4 1.4e-65
XP_011533000 (OMIM: 605903) PREDICTED: PDZ and LIM ( 364) 2352 248.0 3.2e-65
XP_011533001 (OMIM: 605903) PREDICTED: PDZ and LIM ( 309) 2246 237.4 4.3e-62
NP_998801 (OMIM: 605903) PDZ and LIM domain protei ( 222) 1305 143.4 5.9e-34
XP_011537496 (OMIM: 605906,609452) PREDICTED: LIM ( 400) 1045 117.6 6e-26
XP_016871096 (OMIM: 605906,609452) PREDICTED: LIM ( 463) 1041 117.3 8.9e-26
XP_011537495 (OMIM: 605906,609452) PREDICTED: LIM ( 463) 1041 117.3 8.9e-26
XP_011537489 (OMIM: 605906,609452) PREDICTED: LIM ( 748) 1045 117.8 9.9e-26
XP_011537493 (OMIM: 605906,609452) PREDICTED: LIM ( 633) 1041 117.4 1.1e-25
XP_011537491 (OMIM: 605906,609452) PREDICTED: LIM ( 696) 1041 117.4 1.2e-25
XP_016871095 (OMIM: 605906,609452) PREDICTED: LIM ( 743) 1041 117.4 1.3e-25
XP_011537490 (OMIM: 605906,609452) PREDICTED: LIM ( 743) 1041 117.4 1.3e-25
XP_011537487 (OMIM: 605906,609452) PREDICTED: LIM ( 811) 1041 117.4 1.4e-25
XP_011537486 (OMIM: 605906,609452) PREDICTED: LIM ( 811) 1041 117.4 1.4e-25
XP_011537492 (OMIM: 605906,609452) PREDICTED: LIM ( 680) 1030 116.3 2.6e-25
XP_005269521 (OMIM: 605906,609452) PREDICTED: LIM ( 727) 1030 116.3 2.7e-25
NP_009009 (OMIM: 605906,609452) LIM domain-binding ( 727) 1030 116.3 2.7e-25
NP_001073583 (OMIM: 605906,609452) LIM domain-bind ( 617) 1028 116.1 2.8e-25
XP_005269523 (OMIM: 605906,609452) PREDICTED: LIM ( 664) 1028 116.1 2.9e-25
XP_011537488 (OMIM: 605906,609452) PREDICTED: LIM ( 795) 1030 116.3 2.9e-25
NP_001165081 (OMIM: 605906,609452) LIM domain-bind ( 732) 1028 116.1 3.2e-25
XP_005262755 (OMIM: 605904) PREDICTED: PDZ and LIM ( 493) 899 103.1 1.7e-21
XP_016863146 (OMIM: 605904) PREDICTED: PDZ and LIM ( 602) 901 103.4 1.8e-21
NP_001243354 (OMIM: 605904) PDZ and LIM domain pro ( 271) 889 102.0 2.1e-21
NP_001243357 (OMIM: 605904) PDZ and LIM domain pro ( 474) 889 102.1 3.3e-21
NP_001011513 (OMIM: 605904) PDZ and LIM domain pro ( 487) 889 102.1 3.4e-21
XP_016863147 (OMIM: 605904) PREDICTED: PDZ and LIM ( 498) 889 102.1 3.5e-21
NP_006448 (OMIM: 605904) PDZ and LIM domain protei ( 596) 889 102.2 4e-21
XP_011529845 (OMIM: 605904) PREDICTED: PDZ and LIM ( 600) 889 102.2 4e-21
XP_006714133 (OMIM: 605904) PREDICTED: PDZ and LIM ( 605) 889 102.2 4e-21
XP_006714132 (OMIM: 605904) PREDICTED: PDZ and LIM ( 607) 889 102.2 4.1e-21
XP_005262753 (OMIM: 605904) PREDICTED: PDZ and LIM ( 619) 889 102.2 4.1e-21
NP_001243355 (OMIM: 605904) PDZ and LIM domain pro ( 625) 889 102.2 4.2e-21
XP_006714131 (OMIM: 605904) PREDICTED: PDZ and LIM ( 630) 889 102.2 4.2e-21
XP_005262752 (OMIM: 605904) PREDICTED: PDZ and LIM ( 728) 889 102.3 4.7e-21
XP_005262750 (OMIM: 605904) PREDICTED: PDZ and LIM ( 734) 889 102.3 4.7e-21
XP_006714129 (OMIM: 605904) PREDICTED: PDZ and LIM ( 739) 889 102.3 4.8e-21
NP_001243356 (OMIM: 605904) PDZ and LIM domain pro ( 483) 861 99.3 2.3e-20
NP_001011516 (OMIM: 605904) PDZ and LIM domain pro ( 214) 580 71.1 3.3e-12
NP_001158191 (OMIM: 602353) transforming growth fa ( 444) 574 70.7 9.1e-12
NP_057011 (OMIM: 602353) transforming growth facto ( 444) 574 70.7 9.1e-12
NP_001035919 (OMIM: 602353) transforming growth fa ( 461) 574 70.7 9.3e-12
NP_004802 (OMIM: 605390) leupaxin isoform 2 [Homo ( 386) 503 63.6 1.1e-09
NP_001294880 (OMIM: 605390) leupaxin isoform 3 [Ho ( 366) 500 63.3 1.3e-09
XP_011543692 (OMIM: 605390) PREDICTED: leupaxin is ( 366) 500 63.3 1.3e-09
XP_011543693 (OMIM: 605390) PREDICTED: leupaxin is ( 366) 500 63.3 1.3e-09
XP_011543690 (OMIM: 605390) PREDICTED: leupaxin is ( 366) 500 63.3 1.3e-09
NP_001137467 (OMIM: 605390) leupaxin isoform 1 [Ho ( 391) 500 63.3 1.4e-09
XP_016875224 (OMIM: 602505) PREDICTED: paxillin is ( 858) 496 63.1 3.4e-09
>>NP_005442 (OMIM: 605903) PDZ and LIM domain protein 7 (457 aa)
initn: 3252 init1: 3252 opt: 3252 Z-score: 1775.6 bits: 337.8 E(85289): 3.7e-92
Smith-Waterman score: 3252; 100.0% identity (100.0% similar) in 457 aa overlap (1-457:1-457)
10 20 30 40 50 60
pF1KE0 MDSFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MDSFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 LTHIEAQNKIRACGERLSLGLSRAQPVQSKPQKASAPAADPPRYTFAPSVSLNKTARPFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LTHIEAQNKIRACGERLSLGLSRAQPVQSKPQKASAPAADPPRYTFAPSVSLNKTARPFG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 APPPADSAPQQNGQPLRPLVPDASKQRLMENTEDWRPRPGTGQSRSFRILAHLTGTEFMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 APPPADSAPQQNGQPLRPLVPDASKQRLMENTEDWRPRPGTGQSRSFRILAHLTGTEFMQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 DPDEEHLKKSSQVPRTEAPAPASSTPQEPWPGPTAPSPTSRPPWAVDPAFAERYAPDKTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 DPDEEHLKKSSQVPRTEAPAPASSTPQEPWPGPTAPSPTSRPPWAVDPAFAERYAPDKTS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 TVLTRHSQPATPTPLQSRTSIVQAAAGGVPGGGSNNGKTPVCHQCHKVIRGRYLVALGHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TVLTRHSQPATPTPLQSRTSIVQAAAGGVPGGGSNNGKTPVCHQCHKVIRGRYLVALGHA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 YHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPSCAKCKKKITGEIMHALKMTW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 YHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPSCAKCKKKITGEIMHALKMTW
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 HVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKCHGCDFKIDAGDRFLEALGFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 HVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKCHGCDFKIDAGDRFLEALGFS
370 380 390 400 410 420
430 440 450
pF1KE0 WHDTCFVCAICQINLEGKTFYSKKDRPLCKSHAFSHV
:::::::::::::::::::::::::::::::::::::
NP_005 WHDTCFVCAICQINLEGKTFYSKKDRPLCKSHAFSHV
430 440 450
>>NP_976227 (OMIM: 605903) PDZ and LIM domain protein 7 (423 aa)
initn: 2348 init1: 2348 opt: 2366 Z-score: 1298.5 bits: 249.4 E(85289): 1.4e-65
Smith-Waterman score: 2905; 91.5% identity (92.3% similar) in 457 aa overlap (1-457:1-423)
10 20 30 40 50 60
pF1KE0 MDSFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_976 MDSFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 LTHIEAQNKIRACGERLSLGLSRAQPVQSKPQKASAPAADPPRYTFAPSVSLNKTARPFG
:::::::::::::::::::::::::::::::::...:
NP_976 LTHIEAQNKIRACGERLSLGLSRAQPVQSKPQKVQTP-----------------------
70 80 90
130 140 150 160 170 180
pF1KE0 APPPADSAPQQNGQPLRPLVPDASKQRLMENTEDWRPRPGTGQSRSFRILAHLTGTEFMQ
. :::::::::::::::::::::::::::::::::::::::::::::::
NP_976 -----------DKQPLRPLVPDASKQRLMENTEDWRPRPGTGQSRSFRILAHLTGTEFMQ
100 110 120 130 140
190 200 210 220 230 240
pF1KE0 DPDEEHLKKSSQVPRTEAPAPASSTPQEPWPGPTAPSPTSRPPWAVDPAFAERYAPDKTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_976 DPDEEHLKKSSQVPRTEAPAPASSTPQEPWPGPTAPSPTSRPPWAVDPAFAERYAPDKTS
150 160 170 180 190 200
250 260 270 280 290 300
pF1KE0 TVLTRHSQPATPTPLQSRTSIVQAAAGGVPGGGSNNGKTPVCHQCHKVIRGRYLVALGHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_976 TVLTRHSQPATPTPLQSRTSIVQAAAGGVPGGGSNNGKTPVCHQCHKVIRGRYLVALGHA
210 220 230 240 250 260
310 320 330 340 350 360
pF1KE0 YHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPSCAKCKKKITGEIMHALKMTW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_976 YHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPSCAKCKKKITGEIMHALKMTW
270 280 290 300 310 320
370 380 390 400 410 420
pF1KE0 HVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKCHGCDFKIDAGDRFLEALGFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_976 HVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKCHGCDFKIDAGDRFLEALGFS
330 340 350 360 370 380
430 440 450
pF1KE0 WHDTCFVCAICQINLEGKTFYSKKDRPLCKSHAFSHV
:::::::::::::::::::::::::::::::::::::
NP_976 WHDTCFVCAICQINLEGKTFYSKKDRPLCKSHAFSHV
390 400 410 420
>>XP_011533000 (OMIM: 605903) PREDICTED: PDZ and LIM dom (364 aa)
initn: 2348 init1: 2348 opt: 2352 Z-score: 1291.9 bits: 248.0 E(85289): 3.2e-65
Smith-Waterman score: 2352; 95.0% identity (97.1% similar) in 343 aa overlap (115-457:22-364)
90 100 110 120 130 140
pF1KE0 QPVQSKPQKASAPAADPPRYTFAPSVSLNKTARPFGAPPPADSAPQQNGQPLRPLVPDAS
.: ... :. .. :::::::::::
XP_011 MARMRVASHTSKLRTRSGPAGSASAWASAGPSRFRANRRRQPLRPLVPDAS
10 20 30 40 50
150 160 170 180 190 200
pF1KE0 KQRLMENTEDWRPRPGTGQSRSFRILAHLTGTEFMQDPDEEHLKKSSQVPRTEAPAPASS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KQRLMENTEDWRPRPGTGQSRSFRILAHLTGTEFMQDPDEEHLKKSSQVPRTEAPAPASS
60 70 80 90 100 110
210 220 230 240 250 260
pF1KE0 TPQEPWPGPTAPSPTSRPPWAVDPAFAERYAPDKTSTVLTRHSQPATPTPLQSRTSIVQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPQEPWPGPTAPSPTSRPPWAVDPAFAERYAPDKTSTVLTRHSQPATPTPLQSRTSIVQA
120 130 140 150 160 170
270 280 290 300 310 320
pF1KE0 AAGGVPGGGSNNGKTPVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAGGVPGGGSNNGKTPVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEK
180 190 200 210 220 230
330 340 350 360 370 380
pF1KE0 GAIFCPPCYDVRYAPSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GAIFCPPCYDVRYAPSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEG
240 250 260 270 280 290
390 400 410 420 430 440
pF1KE0 VPYCERDYEKMFGTKCHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPYCERDYEKMFGTKCHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKK
300 310 320 330 340 350
450
pF1KE0 DRPLCKSHAFSHV
:::::::::::::
XP_011 DRPLCKSHAFSHV
360
>>XP_011533001 (OMIM: 605903) PREDICTED: PDZ and LIM dom (309 aa)
initn: 2246 init1: 2246 opt: 2246 Z-score: 1235.8 bits: 237.4 E(85289): 4.3e-62
Smith-Waterman score: 2246; 100.0% identity (100.0% similar) in 309 aa overlap (149-457:1-309)
120 130 140 150 160 170
pF1KE0 FGAPPPADSAPQQNGQPLRPLVPDASKQRLMENTEDWRPRPGTGQSRSFRILAHLTGTEF
::::::::::::::::::::::::::::::
XP_011 MENTEDWRPRPGTGQSRSFRILAHLTGTEF
10 20 30
180 190 200 210 220 230
pF1KE0 MQDPDEEHLKKSSQVPRTEAPAPASSTPQEPWPGPTAPSPTSRPPWAVDPAFAERYAPDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MQDPDEEHLKKSSQVPRTEAPAPASSTPQEPWPGPTAPSPTSRPPWAVDPAFAERYAPDK
40 50 60 70 80 90
240 250 260 270 280 290
pF1KE0 TSTVLTRHSQPATPTPLQSRTSIVQAAAGGVPGGGSNNGKTPVCHQCHKVIRGRYLVALG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSTVLTRHSQPATPTPLQSRTSIVQAAAGGVPGGGSNNGKTPVCHQCHKVIRGRYLVALG
100 110 120 130 140 150
300 310 320 330 340 350
pF1KE0 HAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPSCAKCKKKITGEIMHALKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPSCAKCKKKITGEIMHALKM
160 170 180 190 200 210
360 370 380 390 400 410
pF1KE0 TWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKCHGCDFKIDAGDRFLEALG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKCHGCDFKIDAGDRFLEALG
220 230 240 250 260 270
420 430 440 450
pF1KE0 FSWHDTCFVCAICQINLEGKTFYSKKDRPLCKSHAFSHV
:::::::::::::::::::::::::::::::::::::::
XP_011 FSWHDTCFVCAICQINLEGKTFYSKKDRPLCKSHAFSHV
280 290 300
>>NP_998801 (OMIM: 605903) PDZ and LIM domain protein 7 (222 aa)
initn: 1301 init1: 1301 opt: 1305 Z-score: 730.7 bits: 143.4 E(85289): 5.9e-34
Smith-Waterman score: 1305; 95.5% identity (96.5% similar) in 201 aa overlap (1-201:1-201)
10 20 30 40 50 60
pF1KE0 MDSFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_998 MDSFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 LTHIEAQNKIRACGERLSLGLSRAQPVQSKPQKASAPAADPPRYTFAPSVSLNKTARPFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_998 LTHIEAQNKIRACGERLSLGLSRAQPVQSKPQKASAPAADPPRYTFAPSVSLNKTARPFG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 APPPADSAPQQNGQPLRPLVPDASKQRLMENTEDWRPRPGTGQSRSFRILAHLTGTEFMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_998 APPPADSAPQQNGQPLRPLVPDASKQRLMENTEDWRPRPGTGQSRSFRILAHLTGTEFMQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 DPDEEHLKKSSQVPRTEAPAPASSTPQEPWPGPTAPSPTSRPPWAVDPAFAERYAPDKTS
:::::::::: . : .:
NP_998 DPDEEHLKKSREKYVLELQSPRYTRLRDWHHQRSAHVLNVQS
190 200 210 220
>>XP_011537496 (OMIM: 605906,609452) PREDICTED: LIM doma (400 aa)
initn: 1399 init1: 882 opt: 1045 Z-score: 586.8 bits: 117.6 E(85289): 6e-26
Smith-Waterman score: 1056; 38.9% identity (63.6% similar) in 404 aa overlap (65-455:13-397)
40 50 60 70 80 90
pF1KE0 PGGKAAQAGVAVGDWVLSIDGENAGSLTHIEAQNKIRACGERLSLGLSRAQPVQSKPQKA
:: . : . : ... .. .. . .
XP_011 MTGTEFMQDPDEEALRRSRPQASSYSPAVAASSAPATHTSYS
10 20 30 40
100 110 120 130 140 150
pF1KE0 SAPAADPPRYTFAPSVSLNKTARPFGAPPPADSAPQQNGQPLRPLVPDASKQRLMENTED
.::: :. : : . . :: : . . :.. .. : :: ..
XP_011 EGPAAPAPK----PRVVTTASIRPSVYQPAVGQNPMEPASGLGETVPAST----------
50 60 70 80
160 170 180 190 200 210
pF1KE0 WRPRPGTGQSRSFRILAHLTGTEFMQDPDEEHLKKSSQVPR-TEAPAPASSTPQEPWPGP
. : ::.. : . . . :. : :: : .:::: . : .:
XP_011 YSPSPGANYSPT----PYTPSPAPAYTPSPAPAYTPSPVPTYTPSPAPAYTPSPAPNYNP
90 100 110 120 130 140
220 230 240 250 260
pF1KE0 TAPS---------PTSRPPWAVDPAFAERYAPDKTSTVLTRHSQP-ATPTPLQSRTSIVQ
::: :.:::::..: .:....:: :..: ..... : . :. . ..
XP_011 -APSVAYSGGPAEPASRPPWVTDDSFSQKFAPGKSTTSISKQTLPRGGPAYTPAGPQVPP
150 160 170 180 190 200
270 280 290 300 310 320
pF1KE0 AAAGGVPGGGS--NNGKTPVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFF
: : : . ...::.: .:..:::: .:::.:...:::::.:. : : . :
XP_011 LARGTVQRAERFPASSRTPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFV
210 220 230 240 250 260
330 340 350 360 370 380
pF1KE0 EEKGAIFCPPCYDVRYAPSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYM
::.. ..: ::. .:: ::::. :: ::.::::..:::. ::.::::: :. : :.:
XP_011 EEQNNVYCERCYEQFFAPLCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHM
270 280 290 300 310 320
390 400 410 420 430 440
pF1KE0 EEGVPYCERDYEKMFGTKCHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFY
:.: ::::.:: ..:.:::::::: ..:::.:.:::: .::::::.::.:..::::. ::
XP_011 EDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFY
330 340 350 360 370 380
450
pF1KE0 SKKDRPLCKSHAFSHV
:::::::::.:: .
XP_011 SKKDRPLCKKHAHTINL
390 400
>>XP_016871096 (OMIM: 605906,609452) PREDICTED: LIM doma (463 aa)
initn: 1268 init1: 882 opt: 1041 Z-score: 583.7 bits: 117.3 E(85289): 8.9e-26
Smith-Waterman score: 1052; 41.1% identity (64.8% similar) in 372 aa overlap (97-455:108-460)
70 80 90 100 110 120
pF1KE0 QNKIRACGERLSLGLSRAQPVQSKPQKASAPAADPPRYTFAPSVSLNKTARPFGAPPPAD
::: :. : : . . :: : .
XP_016 ADSPRPQASSYSPAVAASSAPATHTSYSEGPAAPAPK----PRVVTTASIRPSVYQPAVG
80 90 100 110 120 130
130 140 150 160 170 180
pF1KE0 SAPQQNGQPLRPLVPDASKQRLMENTEDWRPRPGTGQSRSFRILAHLTGTEFMQDPDEEH
. :.. .. : :: .. . : ::.. : . . . :.
XP_016 QNPMEPASGLGETVPAST----------YSPSPGANYSPT----PYTPSPAPAYTPSPAP
140 150 160 170
190 200 210 220 230
pF1KE0 LKKSSQVPR-TEAPAPASSTPQEPWPGPTAPS---------PTSRPPWAVDPAFAERYAP
: :: : .:::: . : .: ::: :.:::::..: .:....::
XP_016 AYTPSPVPTYTPSPAPAYTPSPAPNYNP-APSVAYSGGPAEPASRPPWVTDDSFSQKFAP
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE0 DKTSTVLTRHSQP-ATPTPLQSRTSIVQAAAGGVPGGGS--NNGKTPVCHQCHKVIRGRY
:..: ..... : . :. . .. : : : . ...::.: .:..:::: .
XP_016 GKSTTSISKQTLPRGGPAYTPAGPQVPPLARGTVQRAERFPASSRTPLCGHCNNVIRGPF
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE0 LVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPSCAKCKKKITGEIM
:::.:...:::::.:. : : . : ::.. ..: ::. .:: ::::. :: ::.:
XP_016 LVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEVM
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE0 HALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKCHGCDFKIDAGDRF
:::..:::. ::.::::: :. : :.::.: ::::.:: ..:.:::::::: ..:::.:
XP_016 HALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKF
360 370 380 390 400 410
420 430 440 450
pF1KE0 LEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCKSHAFSHV
.:::: .::::::.::.:..::::. :::::::::::.:: .
XP_016 IEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCKKHAHTINL
420 430 440 450 460
>>XP_011537495 (OMIM: 605906,609452) PREDICTED: LIM doma (463 aa)
initn: 1268 init1: 882 opt: 1041 Z-score: 583.7 bits: 117.3 E(85289): 8.9e-26
Smith-Waterman score: 1052; 41.1% identity (64.8% similar) in 372 aa overlap (97-455:108-460)
70 80 90 100 110 120
pF1KE0 QNKIRACGERLSLGLSRAQPVQSKPQKASAPAADPPRYTFAPSVSLNKTARPFGAPPPAD
::: :. : : . . :: : .
XP_011 ADSPRPQASSYSPAVAASSAPATHTSYSEGPAAPAPK----PRVVTTASIRPSVYQPAVG
80 90 100 110 120 130
130 140 150 160 170 180
pF1KE0 SAPQQNGQPLRPLVPDASKQRLMENTEDWRPRPGTGQSRSFRILAHLTGTEFMQDPDEEH
. :.. .. : :: .. . : ::.. : . . . :.
XP_011 QNPMEPASGLGETVPAST----------YSPSPGANYSPT----PYTPSPAPAYTPSPAP
140 150 160 170
190 200 210 220 230
pF1KE0 LKKSSQVPR-TEAPAPASSTPQEPWPGPTAPS---------PTSRPPWAVDPAFAERYAP
: :: : .:::: . : .: ::: :.:::::..: .:....::
XP_011 AYTPSPVPTYTPSPAPAYTPSPAPNYNP-APSVAYSGGPAEPASRPPWVTDDSFSQKFAP
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE0 DKTSTVLTRHSQP-ATPTPLQSRTSIVQAAAGGVPGGGS--NNGKTPVCHQCHKVIRGRY
:..: ..... : . :. . .. : : : . ...::.: .:..:::: .
XP_011 GKSTTSISKQTLPRGGPAYTPAGPQVPPLARGTVQRAERFPASSRTPLCGHCNNVIRGPF
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE0 LVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPSCAKCKKKITGEIM
:::.:...:::::.:. : : . : ::.. ..: ::. .:: ::::. :: ::.:
XP_011 LVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEVM
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE0 HALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKCHGCDFKIDAGDRF
:::..:::. ::.::::: :. : :.::.: ::::.:: ..:.:::::::: ..:::.:
XP_011 HALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKF
360 370 380 390 400 410
420 430 440 450
pF1KE0 LEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCKSHAFSHV
.:::: .::::::.::.:..::::. :::::::::::.:: .
XP_011 IEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCKKHAHTINL
420 430 440 450 460
>>XP_011537489 (OMIM: 605906,609452) PREDICTED: LIM doma (748 aa)
initn: 1792 init1: 882 opt: 1045 Z-score: 582.9 bits: 117.8 E(85289): 9.9e-26
Smith-Waterman score: 1056; 38.9% identity (63.6% similar) in 404 aa overlap (65-455:361-745)
40 50 60 70 80 90
pF1KE0 PGGKAAQAGVAVGDWVLSIDGENAGSLTHIEAQNKIRACGERLSLGLSRAQPVQSKPQKA
:: . : . : ... .. .. . .
XP_011 WARRSSNLQSRSFRILAQMTGTEFMQDPDEEALRRSRPQASSYSPAVAASSAPATHTSYS
340 350 360 370 380 390
100 110 120 130 140 150
pF1KE0 SAPAADPPRYTFAPSVSLNKTARPFGAPPPADSAPQQNGQPLRPLVPDASKQRLMENTED
.::: :. : : . . :: : . . :.. .. : :: ..
XP_011 EGPAAPAPK----PRVVTTASIRPSVYQPAVGQNPMEPASGLGETVPAST----------
400 410 420 430
160 170 180 190 200 210
pF1KE0 WRPRPGTGQSRSFRILAHLTGTEFMQDPDEEHLKKSSQVPR-TEAPAPASSTPQEPWPGP
. : ::.. : . . . :. : :: : .:::: . : .:
XP_011 YSPSPGANYSPT----PYTPSPAPAYTPSPAPAYTPSPVPTYTPSPAPAYTPSPAPNYNP
440 450 460 470 480 490
220 230 240 250 260
pF1KE0 TAPS---------PTSRPPWAVDPAFAERYAPDKTSTVLTRHSQP-ATPTPLQSRTSIVQ
::: :.:::::..: .:....:: :..: ..... : . :. . ..
XP_011 -APSVAYSGGPAEPASRPPWVTDDSFSQKFAPGKSTTSISKQTLPRGGPAYTPAGPQVPP
500 510 520 530 540 550
270 280 290 300 310 320
pF1KE0 AAAGGVPGGGS--NNGKTPVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFF
: : : . ...::.: .:..:::: .:::.:...:::::.:. : : . :
XP_011 LARGTVQRAERFPASSRTPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFV
560 570 580 590 600 610
330 340 350 360 370 380
pF1KE0 EEKGAIFCPPCYDVRYAPSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYM
::.. ..: ::. .:: ::::. :: ::.::::..:::. ::.::::: :. : :.:
XP_011 EEQNNVYCERCYEQFFAPLCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHM
620 630 640 650 660 670
390 400 410 420 430 440
pF1KE0 EEGVPYCERDYEKMFGTKCHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFY
:.: ::::.:: ..:.:::::::: ..:::.:.:::: .::::::.::.:..::::. ::
XP_011 EDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFY
680 690 700 710 720 730
450
pF1KE0 SKKDRPLCKSHAFSHV
:::::::::.:: .
XP_011 SKKDRPLCKKHAHTINL
740
>--
initn: 499 init1: 349 opt: 405 Z-score: 237.9 bits: 54.0 E(85289): 1.6e-06
Smith-Waterman score: 431; 31.8% identity (58.4% similar) in 308 aa overlap (3-281:2-302)
10 20 30 40 50 60
pF1KE0 MDSFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGS
:..:.: ::.:::::::::::::.::.:::.:::.::::. .. :: :..::: :. .
XP_011 MSYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDT
10 20 30 40 50
70 80 90 100 110
pF1KE0 LTHIEAQNKIRACGERLSLGLSRAQ-PVQSKPQKASAPAADPPRYTFA----PSVSLNKT
.::.::::::.. . ::: :.... :. : ...:: .. : .. :... : .
XP_011 MTHLEAQNKIKSASYNLSLTLQKSKRPI---PISTTAPPVQTPLPVIPHQKDPALDTNGS
60 70 80 90 100 110
120 130 140 150 160
pF1KE0 ARPFGAPPPADSAPQQNGQP-LRP-LVPDASK----QRLMENTEDWRPRPGTGQSRSFRI
. : : ..: : : ::: . : :. . : : .. :: . . : .
XP_011 LVAPSPSPEARASPGTPGTPELRPTFSPAFSRPSAFSSLAEASDPGPPRASLRAKTSPEG
120 130 140 150 160 170
170 180 190 200 210
pF1KE0 LAHLTGTEFM---------QDP----DEEHLKKSSQVPRTEAPAPASSTPQEPWPGPTAP
: : . . ..: . : :.. .:. . . ::.. :: .
XP_011 ARDLLGPKALPGSSQPRQYNNPIGLYSAETLREMAQMYQMSLRGKASGVGL---PGGADY
180 190 200 210 220 230
220 230 240 250 260 270
pF1KE0 SPTSRPPWAVDPAFAERYAPDKTSTVLTR----HSQPATPTPLQSRTSIVQAAAGGVPGG
. : : :.. . : ... . . :.: :: . :. .:..: :: . .
XP_011 QERFNPSALKDSALST-HKPIEVKGLGGKATIIHAQYNTPISMYSQDAIMDAIAGQAQAQ
240 250 260 270 280 290
280 290 300 310 320 330
pF1KE0 GSN-NGKTPVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPP
::. .:. :.
XP_011 GSDFSGSLPIKDLAVDSASPVYQAVIKSQNKPEDEADEWARRSSNLQSRSFRILAQMTGT
300 310 320 330 340 350
>>XP_011537493 (OMIM: 605906,609452) PREDICTED: LIM doma (633 aa)
initn: 1690 init1: 882 opt: 1041 Z-score: 581.8 bits: 117.4 E(85289): 1.1e-25
Smith-Waterman score: 1052; 41.1% identity (64.8% similar) in 372 aa overlap (97-455:278-630)
70 80 90 100 110 120
pF1KE0 QNKIRACGERLSLGLSRAQPVQSKPQKASAPAADPPRYTFAPSVSLNKTARPFGAPPPAD
::: :. : : . . :: : .
XP_011 ADSPRPQASSYSPAVAASSAPATHTSYSEGPAAPAPK----PRVVTTASIRPSVYQPAVG
250 260 270 280 290 300
130 140 150 160 170 180
pF1KE0 SAPQQNGQPLRPLVPDASKQRLMENTEDWRPRPGTGQSRSFRILAHLTGTEFMQDPDEEH
. :.. .. : :: .. . : ::.. : . . . :.
XP_011 QNPMEPASGLGETVPAST----------YSPSPGANYSPT----PYTPSPAPAYTPSPAP
310 320 330 340
190 200 210 220 230
pF1KE0 LKKSSQVPR-TEAPAPASSTPQEPWPGPTAPS---------PTSRPPWAVDPAFAERYAP
: :: : .:::: . : .: ::: :.:::::..: .:....::
XP_011 AYTPSPVPTYTPSPAPAYTPSPAPNYNP-APSVAYSGGPAEPASRPPWVTDDSFSQKFAP
350 360 370 380 390 400
240 250 260 270 280 290
pF1KE0 DKTSTVLTRHSQP-ATPTPLQSRTSIVQAAAGGVPGGGS--NNGKTPVCHQCHKVIRGRY
:..: ..... : . :. . .. : : : . ...::.: .:..:::: .
XP_011 GKSTTSISKQTLPRGGPAYTPAGPQVPPLARGTVQRAERFPASSRTPLCGHCNNVIRGPF
410 420 430 440 450 460
300 310 320 330 340 350
pF1KE0 LVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPSCAKCKKKITGEIM
:::.:...:::::.:. : : . : ::.. ..: ::. .:: ::::. :: ::.:
XP_011 LVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEVM
470 480 490 500 510 520
360 370 380 390 400 410
pF1KE0 HALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKCHGCDFKIDAGDRF
:::..:::. ::.::::: :. : :.::.: ::::.:: ..:.:::::::: ..:::.:
XP_011 HALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKF
530 540 550 560 570 580
420 430 440 450
pF1KE0 LEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCKSHAFSHV
.:::: .::::::.::.:..::::. :::::::::::.:: .
XP_011 IEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCKKHAHTINL
590 600 610 620 630
>--
initn: 545 init1: 349 opt: 601 Z-score: 344.6 bits: 73.5 E(85289): 1.9e-12
Smith-Waterman score: 601; 41.5% identity (69.5% similar) in 272 aa overlap (3-266:2-265)
10 20 30 40 50 60
pF1KE0 MDSFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGS
:..:.: ::.:::::::::::::.::.:::.:::.::::. .. :: :..::: :. .
XP_011 MSYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDT
10 20 30 40 50
70 80 90 100 110
pF1KE0 LTHIEAQNKIRACGERLSLGLSRAQ-PVQSKPQKASAPAADPPRYTFAP--SVSLNKTAR
.::.::::::.. . ::: :.... :. : ...:: .. : : .: .:. :.
XP_011 MTHLEAQNKIKSASYNLSLTLQKSKRPI---PISTTAPPVQTP-LPVIPHQKVVVNSPAK
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE0 --PFGAPPPADSAPQQNGQPLRPLVPDASKQRLMENTEDWRPRPGTGQSRSFRILAHLTG
:... : : : . ...:. : :... .....: : .. :::::::::..::
XP_011 ASPLASLPIKDLAVD-SASPVYQAVIK-SQNKPEDEADEWARRSSNLQSRSFRILAQMTG
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE0 TEFMQDPDEEHLKKSSQVPRTEAPAPASSTPQEPWPGPTAPSPTSRPPWAVDPAFAERYA
:::::::::: :..:: .: .::. .:.. :. . : :.. : :..: .: :
XP_011 TEFMQDPDEEALRRSS-TPIEHAPVCTSQATTPLLPASAQP-PAAASPSAASPPLATAAA
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE0 PDKTSTVLTRH--SQPA-TPTPLQSRTSIVQAAAGGVPGGGSNNGKTPVCHQCHKVIRGR
... : :.:: .: : : : . ::.
XP_011 HTAIASASTTAPASSPADSPRPQASSYSPAVAASSAPATHTSYSEGPAAPAPKPRVVTTA
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE0 YLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPSCAKCKKKITGEI
XP_011 SIRPSVYQPAVGQNPMEPASGLGETVPASTYSPSPGANYSPTPYTPSPAPAYTPSPAPAY
300 310 320 330 340 350
457 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 18:05:55 2016 done: Sat Nov 5 18:05:56 2016
Total Scan time: 10.930 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]