FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0795, 358 aa 1>>>pF1KE0795 358 - 358 aa - 358 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.4745+/-0.000783; mu= 7.3726+/- 0.047 mean_var=145.3242+/-28.074, 0's: 0 Z-trim(113.4): 85 B-trim: 221 in 1/50 Lambda= 0.106391 statistics sampled from 13898 (14001) to 13898 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.762), E-opt: 0.2 (0.43), width: 16 Scan time: 3.290 The best scores are: opt bits E(32554) CCDS11705.1 SLC9A3R1 gene_id:9368|Hs108|chr17 ( 358) 2370 374.9 5.8e-104 CCDS45382.1 SLC9A3R2 gene_id:9351|Hs108|chr16 ( 337) 999 164.5 1.2e-40 CCDS45383.1 SLC9A3R2 gene_id:9351|Hs108|chr16 ( 326) 998 164.3 1.3e-40 CCDS58407.1 SLC9A3R2 gene_id:9351|Hs108|chr16 ( 226) 598 102.8 3e-22 CCDS72859.1 PDZK1 gene_id:5174|Hs108|chr1 ( 408) 482 85.2 1.1e-16 CCDS8417.1 PDZD3 gene_id:79849|Hs108|chr11 ( 491) 426 76.6 4.9e-14 CCDS53719.1 PDZD3 gene_id:79849|Hs108|chr11 ( 505) 426 76.6 5e-14 >>CCDS11705.1 SLC9A3R1 gene_id:9368|Hs108|chr17 (358 aa) initn: 2370 init1: 2370 opt: 2370 Z-score: 1980.0 bits: 374.9 E(32554): 5.8e-104 Smith-Waterman score: 2370; 100.0% identity (100.0% similar) in 358 aa overlap (1-358:1-358) 10 20 30 40 50 60 pF1KE0 MSADAAAGAPLPRLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 MSADAAAGAPLPRLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 EVNGENVEKETHQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 EVNGENVEKETHQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 EPPAAAEVQGAGNENEPREADKSHPEQRELRPRLCTMKKGPSGYGFNLHSDKSKPGQFIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 EPPAAAEVQGAGNENEPREADKSHPEQRELRPRLCTMKKGPSGYGFNLHSDKSKPGQFIR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 SVDPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 SVDPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 KCRVIPSQEHLNGPLPVPFTNGEIQKENSREALAEAALESPRPALVRSASSDTSEELNSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 KCRVIPSQEHLNGPLPVPFTNGEIQKENSREALAEAALESPRPALVRSASSDTSEELNSQ 250 260 270 280 290 300 310 320 330 340 350 pF1KE0 DSPPKQDSTAPSSTSSSDPILDFNISLAMAKERAHQKRSSKRAPQMDWSKKNELFSNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 DSPPKQDSTAPSSTSSSDPILDFNISLAMAKERAHQKRSSKRAPQMDWSKKNELFSNL 310 320 330 340 350 >>CCDS45382.1 SLC9A3R2 gene_id:9351|Hs108|chr16 (337 aa) initn: 1083 init1: 966 opt: 999 Z-score: 843.1 bits: 164.5 E(32554): 1.2e-40 Smith-Waterman score: 1104; 52.1% identity (72.0% similar) in 361 aa overlap (6-358:2-337) 10 20 30 40 50 pF1KE0 MSADAAAGAPL-PRLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRL :: :: :::: : .: .:::::::::::. ::.:: :::::::: :.: ::::: CCDS45 MAAPEPLRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRL 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 VEVNGENVEKETHQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEA-PG ::::: ::: :::.:::.::.:. . .:::::: ::::.:.. . ::. ::.. : CCDS45 VEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEM--AQRGLPP 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 QAEP--PAAAEVQGAGNENEPREADKSHPEQRELRPRLCTMKKGPSGYGFNLHSDKSKPG .: : .. ... .: . : : : :::::::: ..:::.:::::::::::.:: CCDS45 AHDPWEPKPDWAHTGSHSSEAGKKDVSGP-LRELRPRLCHLRKGPQGYGFNLHSDKSRPG 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 QFIRSVDPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETD :.:::::: ::: ::::::::..:::: .:: .:..::..:.: ::..::::: ::: CCDS45 QYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETD 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE0 EFFKKCRVIPSQEHLNGPLPVPFTNGEIQKENSREALAEAALESPRPALVRSASSDTSEE : ::. :: :..::..:::: : ::: :: . ..:. .:. CCDS45 EHFKRLRVTPTEEHVEGPLPSPVTNGT------------------SPAQLNGGSACSSR- 240 250 260 270 300 310 320 330 340 350 pF1KE0 LNSQDSPPKQDSTAPSSTSSSDPILDFNISL----AMAKERAHQKRSSKRAPQMDWSKKN .: : .. .: .:. ..::. . .. : : :::.:. : .::::::::..: CCDS45 ---SDLPGSDKDTEDGSAWKQDPFQESGLHLSPTAAEAKEKARAMRVNKRAPQMDWNRKR 280 290 300 310 320 330 pF1KE0 ELFSNL :.:::. CCDS45 EIFSNF >>CCDS45383.1 SLC9A3R2 gene_id:9351|Hs108|chr16 (326 aa) initn: 1083 init1: 966 opt: 998 Z-score: 842.5 bits: 164.3 E(32554): 1.3e-40 Smith-Waterman score: 1084; 52.1% identity (71.1% similar) in 357 aa overlap (6-358:2-326) 10 20 30 40 50 pF1KE0 MSADAAAGAPL-PRLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRL :: :: :::: : .: .:::::::::::. ::.:: :::::::: :.: ::::: CCDS45 MAAPEPLRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRL 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 VEVNGENVEKETHQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEA-PG ::::: ::: :::.:::.::.:. . .:::::: ::::.:.. . ::. ::.. : CCDS45 VEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEM--AQRGLPP 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 QAEP--PAAAEVQGAGNENEPREADKSHPEQRELRPRLCTMKKGPSGYGFNLHSDKSKPG .: : .. ... .: . : : : :::::::: ..:::.:::::::::::.:: CCDS45 AHDPWEPKPDWAHTGSHSSEAGKKDVSGP-LRELRPRLCHLRKGPQGYGFNLHSDKSRPG 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 QFIRSVDPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETD :.:::::: ::: ::::::::..:::: .:: .:..::..:.: ::..::::: ::: CCDS45 QYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETD 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE0 EFFKKCRVIPSQEHLNGPLPVPFTNGEIQKENSREALAEAALESPRPALVRSASSDTSEE : ::. :: :..::..:::: : ::: :: . ..:. .:. CCDS45 EHFKRLRVTPTEEHVEGPLPSPVTNGT------------------SPAQLNGGSACSSR- 240 250 260 270 300 310 320 330 340 350 pF1KE0 LNSQDSPPKQDSTAPSSTSSSDPILDFNISLAMAKERAHQKRSSKRAPQMDWSKKNELFS .: : .. .: :. : .. . : :::.:. : .::::::::..: :.:: CCDS45 ---SDLPGSDKDTEESG-------LHLSPTAAEAKEKARAMRVNKRAPQMDWNRKREIFS 280 290 300 310 320 pF1KE0 NL :. CCDS45 NF >>CCDS58407.1 SLC9A3R2 gene_id:9351|Hs108|chr16 (226 aa) initn: 677 init1: 560 opt: 598 Z-score: 512.9 bits: 102.8 E(32554): 3e-22 Smith-Waterman score: 703; 49.0% identity (69.6% similar) in 247 aa overlap (118-358:5-226) 90 100 110 120 130 140 pF1KE0 LLVVDPETDEQLQKLGVQVREELLRAQEAPGQAEPPAAAEVQGAGNENEPRE--ADKSHP :.: ::: : :: .. :.. : : : CCDS58 MARSGSATPPARA--PGAPPRSPPQRLVQDVSGP 10 20 30 150 160 170 180 190 200 pF1KE0 EQRELRPRLCTMKKGPSGYGFNLHSDKSKPGQFIRSVDPDSPAEASGLRAQDRIVEVNGV :::::::: ..:::.:::::::::::.:::.:::::: ::: ::::::::..:::: CCDS58 -LRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAARSGLRAQDRLIEVNGQ 40 50 60 70 80 90 210 220 230 240 250 260 pF1KE0 CMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFKKCRVIPSQEHLNGPLPVPFTNGEIQ .:: .:..::..:.: ::..::::: :::: ::. :: :..::..:::: : ::: CCDS58 NVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTPTEEHVEGPLPSPVTNGT-- 100 110 120 130 140 270 280 290 300 310 320 pF1KE0 KENSREALAEAALESPRPALVRSASSDTSEELNSQDSPPKQDSTAPSSTSSSDPILDFNI :: . ..:. .:. .: : .. .: .:. ..::. . .. CCDS58 ----------------SPAQLNGGSACSSR----SDLPGSDKDTEDGSAWKQDPFQESGL 150 160 170 180 330 340 350 pF1KE0 SL----AMAKERAHQKRSSKRAPQMDWSKKNELFSNL : : :::.:. : .::::::::..: :.:::. CCDS58 HLSPTAAEAKEKARAMRVNKRAPQMDWNRKREIFSNF 190 200 210 220 >>CCDS72859.1 PDZK1 gene_id:5174|Hs108|chr1 (408 aa) initn: 511 init1: 246 opt: 482 Z-score: 413.0 bits: 85.2 E(32554): 1.1e-16 Smith-Waterman score: 488; 34.0% identity (61.2% similar) in 291 aa overlap (12-302:133-406) 10 20 30 40 pF1KE0 MSADAAAGAPLPRLCCLEKGPNGYGFHLHGEKGKLGQYIRL :::: : : ..::: : : :: :. CCDS72 KELGQSQKEQGLSDNILSPVMNGGVQTWTQPRLCYLVKEGGSYGFSL---KTVQGQIIKD 110 120 130 140 150 50 60 70 80 90 100 pF1KE0 VEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQVVSRIRAALNAVRLLVVDPETDEQLQK .. :::::.::: .: .: ::::.:: :..:: :: . . . ::::: :::. . . CCDS72 IDSGSPAEEAGLKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLLVVDKETDN-MYR 160 170 180 190 200 210 110 120 130 140 150 160 pF1KE0 LGVQVREELLRAQEAPGQAEPPAAAEVQGAGNENEPREADKSHPEQRELRPRLCTMKKGP :. ..:: :. . : : . . . . : .. :. . .:.:: . :: CCDS72 LAHFSPFLYYQSQELPNGSVKEAPAPTPTSLEVSSPPDTT----EEVDHKPKLCRLAKGE 220 230 240 250 260 270 170 180 190 200 210 220 pF1KE0 SGYGFNLHSDKSKPGQFIRSVDPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIRA .::::.:.. .. ::.::. :. .::. .::. .: :.::::: . . . ::. :.. CCDS72 NGYGFHLNAIRGLPGSFIKEVQKGGPADLAGLEDEDVIIEVNGVNVLDEPYEKVVDRIQS 280 290 300 310 320 330 230 240 250 260 270 280 pF1KE0 GGDETKLLVVDRETDEFFKKCRVIPSQEHLNGPLPVPFTNGEIQKENSREALAEAALESP .: .. ::: ... ..:. . :: : :: .: .:.:... . .. CCDS72 SGKNVTLLVCGKKAYDYFQAKK-IPIVSSLADPLDTP--------PDSKEGIVVESNHDS 340 350 360 370 380 290 300 310 320 330 340 pF1KE0 RPALVRSASSDTSEELNSQDSPPKQDSTAPSSTSSSDPILDFNISLAMAKERAHQKRSSK . : :. :. . ::.:. CCDS72 HMAKERAHSTASHSSSNSEDTEM 390 400 >>CCDS8417.1 PDZD3 gene_id:79849|Hs108|chr11 (491 aa) initn: 570 init1: 215 opt: 426 Z-score: 365.4 bits: 76.6 E(32554): 4.9e-14 Smith-Waterman score: 426; 41.7% identity (61.9% similar) in 218 aa overlap (1-210:233-444) 10 20 pF1KE0 MSADAAAGAPLP---RLCCLEKGPNGYGFH ..: : : :: : :::::.:.:: CCDS84 VNGLWQSGQQVTLLVAGPEVEEQCRQLGLPLAAPLAEGWALPTKPRCLHLEKGPQGFGFL 210 220 230 240 250 260 30 40 50 60 70 80 pF1KE0 LHGEKG---KLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQVVSRIRAALN :. ::: . ::.. :.:: ::.:::. :::::: : ::.:: :...::::.. . CCDS84 LREEKGLDGRPGQFLWEVDPGLPAKKAGMQAGDRLVAVAGESVEGLGHEETVSRIQGQGS 270 280 290 300 310 320 90 100 110 120 130 140 pF1KE0 AVRLLVVDPETDEQLQKLGVQVREEL-LRAQEAPGQAEPPAAAEVQGAGNENEPREADKS : : :::::.:. .. :.. : :. ::: : : ... .. . .:. : : : CCDS84 CVSLTVVDPEADRFFSM--VRLSPLLFLENTEAP--ASPRGSSSASLVETED-PSLEDTS 330 340 350 360 370 150 160 170 180 190 200 pF1KE0 HPEQRELRPRLCTMKKGPSG-YGFNLHSDKSKPGQFIRSVDPDSPAEASGLRAQDRIVEV : . : : : . ::.: ::: : : : :: .: : . : .::.. : :.:: CCDS84 VP-SVPLGSRQCFLYPGPGGSYGFRLSCVASGPRLFISQVTPGGSAARAGLQVGDVILEV 380 390 400 410 420 430 210 220 230 240 250 260 pF1KE0 NGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFKKCRVIPSQEHLNGPLPVPFTNG :: . :. CCDS84 NGYPVGGQNDLERLQQLPEAEPPLCLKLAARSLRGLEAWIPPGAAEDWALASDLL 440 450 460 470 480 490 >>CCDS53719.1 PDZD3 gene_id:79849|Hs108|chr11 (505 aa) initn: 621 init1: 215 opt: 426 Z-score: 365.2 bits: 76.6 E(32554): 5e-14 Smith-Waterman score: 426; 41.7% identity (61.9% similar) in 218 aa overlap (1-210:247-458) 10 20 pF1KE0 MSADAAAGAPLP---RLCCLEKGPNGYGFH ..: : : :: : :::::.:.:: CCDS53 TRKLWQSGQQVTLLVAGPEVEEQCRQLGLPLAAPLAEGWALPTKPRCLHLEKGPQGFGFL 220 230 240 250 260 270 30 40 50 60 70 80 pF1KE0 LHGEKG---KLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQVVSRIRAALN :. ::: . ::.. :.:: ::.:::. :::::: : ::.:: :...::::.. . CCDS53 LREEKGLDGRPGQFLWEVDPGLPAKKAGMQAGDRLVAVAGESVEGLGHEETVSRIQGQGS 280 290 300 310 320 330 90 100 110 120 130 140 pF1KE0 AVRLLVVDPETDEQLQKLGVQVREEL-LRAQEAPGQAEPPAAAEVQGAGNENEPREADKS : : :::::.:. .. :.. : :. ::: : : ... .. . .:. : : : CCDS53 CVSLTVVDPEADRFFSM--VRLSPLLFLENTEAP--ASPRGSSSASLVETED-PSLEDTS 340 350 360 370 380 390 150 160 170 180 190 200 pF1KE0 HPEQRELRPRLCTMKKGPSG-YGFNLHSDKSKPGQFIRSVDPDSPAEASGLRAQDRIVEV : . : : : . ::.: ::: : : : :: .: : . : .::.. : :.:: CCDS53 VP-SVPLGSRQCFLYPGPGGSYGFRLSCVASGPRLFISQVTPGGSAARAGLQVGDVILEV 400 410 420 430 440 450 210 220 230 240 250 260 pF1KE0 NGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFKKCRVIPSQEHLNGPLPVPFTNG :: . :. CCDS53 NGYPVGGQNDLERLQQLPEAEPPLCLKLAARSLRGLEAWIPPGAAEDWALASDLL 460 470 480 490 500 358 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 03:11:52 2016 done: Sat Nov 5 03:11:52 2016 Total Scan time: 3.290 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]