FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0805, 360 aa 1>>>pF1KE0805 360 - 360 aa - 360 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4731+/-0.00105; mu= 16.0806+/- 0.063 mean_var=195.7431+/-83.683, 0's: 0 Z-trim(105.5): 315 B-trim: 913 in 2/49 Lambda= 0.091671 statistics sampled from 7947 (8461) to 7947 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.61), E-opt: 0.2 (0.26), width: 16 Scan time: 2.080 The best scores are: opt bits E(32554) CCDS13449.2 MC3R gene_id:4159|Hs108|chr20 ( 323) 2166 299.8 2.2e-81 CCDS11868.1 MC5R gene_id:4161|Hs108|chr18 ( 325) 1325 188.5 6.7e-48 CCDS11976.1 MC4R gene_id:4160|Hs108|chr18 ( 332) 1273 181.7 8e-46 CCDS56011.1 MC1R gene_id:4157|Hs108|chr16 ( 317) 958 140.0 2.7e-33 CCDS11869.1 MC2R gene_id:4158|Hs108|chr18 ( 297) 583 90.3 2.2e-18 >>CCDS13449.2 MC3R gene_id:4159|Hs108|chr20 (323 aa) initn: 2166 init1: 2166 opt: 2166 Z-score: 1574.6 bits: 299.8 E(32554): 2.2e-81 Smith-Waterman score: 2166; 100.0% identity (100.0% similar) in 323 aa overlap (38-360:1-323) 10 20 30 40 50 60 pF1KE0 LEGDFVFPVSSSSFLRTLLEPQLGSALLTAMNASCCLPSVQPTLPNGSEHLQAPFFSNQS :::::::::::::::::::::::::::::: CCDS13 MNASCCLPSVQPTLPNGSEHLQAPFFSNQS 10 20 30 70 80 90 100 110 120 pF1KE0 SSAFCEQVFIKPEVFLSLGIVSLLENILVILAVVRNGNLHSPMYFFLCSLAVADMLVSVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 SSAFCEQVFIKPEVFLSLGIVSLLENILVILAVVRNGNLHSPMYFFLCSLAVADMLVSVS 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE0 NALETIMIAIVHSDYLTFEDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 NALETIMIAIVHSDYLTFEDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYAL 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE0 RYHSIMTVRKALTLIVAIWVCCGVCGVVFIVYSESKMVIVCLITMFFAMMLLMGTLYVHM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 RYHSIMTVRKALTLIVAIWVCCGVCGVVFIVYSESKMVIVCLITMFFAMMLLMGTLYVHM 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE0 FLFARLHVKRIAALPPADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 FLFARLHVKRIAALPPADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPT 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE0 NPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFREILCGCNGMNLG ::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 NPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFREILCGCNGMNLG 280 290 300 310 320 >>CCDS11868.1 MC5R gene_id:4161|Hs108|chr18 (325 aa) initn: 1280 init1: 891 opt: 1325 Z-score: 973.4 bits: 188.5 E(32554): 6.7e-48 Smith-Waterman score: 1325; 61.6% identity (85.1% similar) in 323 aa overlap (38-359:1-317) 10 20 30 40 50 60 pF1KE0 LEGDFVFPVSSSSFLRTLLEPQLGSALLTAMNASCCLPSVQPTLPNGSE-HLQAPFFSNQ ::.: : .. .: :..: .:..: .:. CCDS11 MNSSFHLHFLDLNL-NATEGNLSGPNVKNK 10 20 70 80 90 100 110 120 pF1KE0 SSSAFCEQVFIKPEVFLSLGIVSLLENILVILAVVRNGNLHSPMYFFLCSLAVADMLVSV :: ::.. : ::::.::..::::::::: :.:.: :::::::::.:::::::::::. CCDS11 SSP--CEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSM 30 40 50 60 70 80 130 140 150 160 170 180 pF1KE0 SNALETIMIAIVHSDYLTFEDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYA :.: ::: : .... .:.. : :..:.::.::::::::.:::.:.::::::::::::::: CCDS11 SSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYA 90 100 110 120 130 140 190 200 210 220 230 240 pF1KE0 LRYHSIMTVRKALTLIVAIWVCCGVCGVVFIVYSESKMVIVCLITMFFAMMLLMGTLYVH :::: :::.:.. ..:..::. : ::.:::.:::: .::.:::.:::::..:. .::.: CCDS11 LRYHHIMTARRSGAIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFAMLFLLVSLYIH 150 160 170 180 190 200 250 260 270 280 290 300 pF1KE0 MFLFARLHVKRIAALPPADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCP :::.:: ::::::::: :. . .:.. :.::::.:.::::: :::::::::.:...:: CCDS11 MFLLARTHVKRIAALPGAS--SARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCP 210 220 230 240 250 260 310 320 330 340 350 360 pF1KE0 TNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFREILCGCNGMNLG : :: . .::: ::.:::::::.::::::::: :.:.::.::.: : :. . CCDS11 QNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIIC-CRGFRIACSFPRR 270 280 290 300 310 320 CCDS11 D >>CCDS11976.1 MC4R gene_id:4160|Hs108|chr18 (332 aa) initn: 1267 init1: 514 opt: 1273 Z-score: 936.2 bits: 181.7 E(32554): 8e-46 Smith-Waterman score: 1273; 61.4% identity (85.5% similar) in 303 aa overlap (53-354:26-319) 30 40 50 60 70 80 pF1KE0 RTLLEPQLGSALLTAMNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFC-EQVFIKPEV :.:: : . :.. : ::.:..::: CCDS11 MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGY-----SDGGCYEQLFVSPEV 10 20 30 40 50 90 100 110 120 130 140 pF1KE0 FLSLGIVSLLENILVILAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSD :..::..:::::::::.:...: :::::::::.::::::::::::::. :::.:....: CCDS11 FVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNST 60 70 80 90 100 110 150 160 170 180 190 200 pF1KE0 YLTFEDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTL : ..: ..::..::.:: ::.::::.::.:::::: ::::::.::.::::... . CCDS11 D-TDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGII 120 130 140 150 160 210 220 230 240 250 260 pF1KE0 IVAIWVCCGVCGVVFIVYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAAL : ::. : : :..::.::.:. ::.:::::::.:. ::..:::::::.::::.::::.: CCDS11 ISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVL 170 180 190 200 210 220 270 280 290 300 310 320 pF1KE0 PPADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTY : . .. .: . ::::.:.:::.:::. :::::::::.. :.:: ::::.:. .::: : CCDS11 PGTGAI--RQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLY 230 240 250 260 270 280 330 340 350 360 pF1KE0 LVLIMCNSVIDPLIYAFRSLELRNTFREILCGCNGMNLG :.::::::.:::::::.:: :::.::.::.: : CCDS11 LILIMCNSIIDPLIYALRSQELRKTFKEIIC-CYPLGGLCDLSSRY 290 300 310 320 330 >>CCDS56011.1 MC1R gene_id:4157|Hs108|chr16 (317 aa) initn: 940 init1: 584 opt: 958 Z-score: 711.2 bits: 140.0 E(32554): 2.7e-33 Smith-Waterman score: 958; 49.5% identity (77.6% similar) in 295 aa overlap (59-352:23-315) 30 40 50 60 70 80 pF1KE0 QLGSALLTAMNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIV : . .::.. : : .: :. .:::::.: CCDS56 MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTG-ARCLEVSISDGLFLSLGLV 10 20 30 40 50 90 100 110 120 130 140 pF1KE0 SLLENILVILAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQ ::.:: ::. ....: ::::::: :.: ::..:.::: ::.::: .: .... :. . CCDS56 SLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAA 60 70 80 90 100 110 150 160 170 180 190 200 pF1KE0 FIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVC .:..::..: . : :...:.: : :::::::..::::::::::.:. .: ..:::: CCDS56 VLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVA 120 130 140 150 160 170 210 220 230 240 250 260 pF1KE0 CGVCGVVFIVYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVA : ...::.: . :..::...:.::..::..:::::. : :.. :: : . . CCDS56 SVVFSTLFIAYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPV 180 190 200 210 220 230 270 280 290 300 310 320 pF1KE0 PQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCN : . .:::::.:::::.:..::.::::::.::. :: .: : : .:: .:.::.:: CCDS56 HQGFG-LKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICN 240 250 260 270 280 290 330 340 350 360 pF1KE0 SVIDPLIYAFRSLELRNTFREIL-CGCNGMNLG ..::::::::.: ::: :..:.: : CCDS56 AIIDPLIYAFHSQELRRTLKEVLTCSW 300 310 >>CCDS11869.1 MC2R gene_id:4158|Hs108|chr18 (297 aa) initn: 951 init1: 583 opt: 583 Z-score: 443.4 bits: 90.3 E(32554): 2.2e-18 Smith-Waterman score: 940; 47.9% identity (79.8% similar) in 282 aa overlap (72-352:21-293) 50 60 70 80 90 100 pF1KE0 CCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVILAVV : .: . :.:....::..:::..:.::: CCDS11 MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVF 10 20 30 40 50 110 120 130 140 150 160 pF1KE0 RNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIFDSMI .: ::..:::::.::::..::: :. . ::.:.: . . :: . .: :.:.::.. CCDS11 KNKNLQAPMYFFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLF 60 70 80 90 100 110 170 180 190 200 210 220 pF1KE0 CISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFIVYSE .::..:: .: .::.:::.:::.:::::::.:.:........::. : :......:. CCDS11 VLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSH 120 130 140 150 160 170 230 240 250 260 270 280 pF1KE0 SKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKGAVTI ... . ..: :.... :::::::.:: :...:..:: :. ::::.:. CCDS11 HVPTVITFTSLFPLMLVFILCLYVHMFLLARSHTRKISTLPRAN---------MKGAITL 180 190 200 210 220 290 300 310 320 330 340 pF1KE0 TILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSL :::::::::::::: ::..:. ::.:::: :: . :.. .:::::.::::.:::::: CCDS11 TILLGVFIFCWAPFVLHVLLMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSP 230 240 250 260 270 280 350 360 pF1KE0 ELRNTFRE-ILCGCNGMNLG :::..:.. :.: CCDS11 ELRDAFKKMIFCSRYW 290 360 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 03:14:45 2016 done: Sat Nov 5 03:14:45 2016 Total Scan time: 2.080 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]