FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0903, 168 aa 1>>>pF1KE0903 168 - 168 aa - 168 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.7724+/-0.000437; mu= 0.3154+/- 0.026 mean_var=364.3561+/-85.036, 0's: 0 Z-trim(116.9): 343 B-trim: 0 in 0/49 Lambda= 0.067191 statistics sampled from 28034 (28400) to 28034 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.716), E-opt: 0.2 (0.333), width: 16 Scan time: 5.680 The best scores are: opt bits E(85289) NP_001243242 (OMIM: 605030) serine/threonine-prote ( 380) 766 88.1 1.6e-17 XP_016869250 (OMIM: 605030) PREDICTED: serine/thre ( 403) 764 88.0 1.9e-17 XP_016869247 (OMIM: 605030) PREDICTED: serine/thre ( 456) 764 88.1 2e-17 NP_006272 (OMIM: 605030) serine/threonine-protein ( 491) 764 88.1 2.1e-17 XP_011515553 (OMIM: 605030) PREDICTED: serine/thre ( 522) 764 88.2 2.2e-17 XP_016869251 (OMIM: 605030) PREDICTED: serine/thre ( 313) 703 81.9 1e-15 XP_011515559 (OMIM: 605030) PREDICTED: serine/thre ( 313) 703 81.9 1e-15 XP_011515554 (OMIM: 605030) PREDICTED: serine/thre ( 465) 705 82.4 1.1e-15 NP_001243241 (OMIM: 605030) serine/threonine-prote ( 519) 703 82.2 1.3e-15 XP_016869246 (OMIM: 605030) PREDICTED: serine/thre ( 524) 703 82.2 1.3e-15 XP_011515550 (OMIM: 605030) PREDICTED: serine/thre ( 576) 703 82.3 1.4e-15 XP_016869245 (OMIM: 605030) PREDICTED: serine/thre ( 580) 703 82.3 1.4e-15 XP_016883522 (OMIM: 604965,614868) PREDICTED: seri ( 388) 687 80.5 3.3e-15 XP_005260590 (OMIM: 604965,614868) PREDICTED: seri ( 462) 687 80.6 3.6e-15 NP_006273 (OMIM: 604965,614868) serine/threonine-p ( 487) 687 80.6 3.7e-15 XP_011527322 (OMIM: 604965,614868) PREDICTED: seri ( 404) 677 79.5 6.6e-15 XP_005260588 (OMIM: 604965,614868) PREDICTED: seri ( 478) 677 79.7 7.2e-15 XP_005260587 (OMIM: 604965,614868) PREDICTED: seri ( 503) 677 79.7 7.4e-15 XP_016883521 (OMIM: 604965,614868) PREDICTED: seri ( 458) 526 65.0 1.8e-10 XP_005260589 (OMIM: 604965,614868) PREDICTED: seri ( 474) 517 64.1 3.3e-10 XP_016883518 (OMIM: 604965,614868) PREDICTED: seri ( 474) 517 64.1 3.3e-10 XP_016883520 (OMIM: 604965,614868) PREDICTED: seri ( 474) 517 64.1 3.3e-10 XP_016883519 (OMIM: 604965,614868) PREDICTED: seri ( 474) 517 64.1 3.3e-10 XP_016876283 (OMIM: 604984) PREDICTED: serine/thre ( 517) 352 48.2 2.3e-05 XP_016876284 (OMIM: 604984) PREDICTED: serine/thre ( 474) 348 47.8 2.8e-05 NP_001027467 (OMIM: 604984) serine/threonine-prote ( 431) 347 47.6 2.9e-05 NP_003567 (OMIM: 604984) serine/threonine-protein ( 443) 347 47.6 2.9e-05 NP_001035917 (OMIM: 300547) serine/threonine-prote ( 354) 336 46.4 5.5e-05 NP_057626 (OMIM: 300547) serine/threonine-protein ( 416) 336 46.5 6e-05 XP_011508798 (OMIM: 602255) PREDICTED: serine/thre ( 334) 327 45.5 9.7e-05 XP_016858657 (OMIM: 602255) PREDICTED: serine/thre ( 365) 327 45.5 0.0001 XP_016858658 (OMIM: 602255) PREDICTED: serine/thre ( 365) 327 45.5 0.0001 XP_011508795 (OMIM: 602255) PREDICTED: serine/thre ( 376) 327 45.6 0.0001 NP_006365 (OMIM: 602255) serine/threonine-protein ( 426) 327 45.7 0.00011 NP_001258906 (OMIM: 602255) serine/threonine-prote ( 426) 327 45.7 0.00011 NP_001258907 (OMIM: 602255) serine/threonine-prote ( 426) 327 45.7 0.00011 XP_011527320 (OMIM: 604965,614868) PREDICTED: seri ( 411) 301 43.1 0.00062 NP_001036065 (OMIM: 601983) mitogen-activated prot ( 821) 293 42.8 0.0015 NP_009112 (OMIM: 601983) mitogen-activated protein ( 833) 293 42.8 0.0015 XP_011524706 (OMIM: 601983) PREDICTED: mitogen-act ( 861) 293 42.8 0.0016 XP_011524705 (OMIM: 601983) PREDICTED: mitogen-act ( 873) 293 42.9 0.0016 NP_001257354 (OMIM: 604921) mitogen-activated prot ( 873) 288 42.4 0.0022 NP_003609 (OMIM: 604921) mitogen-activated protein ( 894) 288 42.4 0.0022 XP_016873585 (OMIM: 603166) PREDICTED: mitogen-act ( 584) 271 40.4 0.0056 NP_005981 (OMIM: 603919) serine/threonine-protein ( 968) 273 41.0 0.0064 XP_016873582 (OMIM: 603166) PREDICTED: mitogen-act ( 768) 271 40.6 0.0065 XP_011543506 (OMIM: 603166) PREDICTED: mitogen-act ( 776) 271 40.6 0.0065 XP_011543505 (OMIM: 603166) PREDICTED: mitogen-act ( 797) 271 40.7 0.0066 NP_001294919 (OMIM: 603166) mitogen-activated prot ( 812) 271 40.7 0.0067 NP_004570 (OMIM: 603166) mitogen-activated protein ( 820) 271 40.7 0.0067 >>NP_001243242 (OMIM: 605030) serine/threonine-protein k (380 aa) initn: 803 init1: 765 opt: 766 Z-score: 435.5 bits: 88.1 E(85289): 1.6e-17 Smith-Waterman score: 766; 96.0% identity (97.6% similar) in 124 aa overlap (1-123:1-124) 10 20 30 40 50 60 pF1KE0 MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 ESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTG-F :::::::::::::::::::::::::::::::::::::::::::::::::::::::::. : NP_001 ESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTAIF 70 80 90 100 110 120 120 130 140 150 160 pF1KE0 LTDTTEGSASCDLRMDLTLFHLGAEFLHYLLLYEADPLSCVFSLLVFSV . : NP_001 MIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLI 130 140 150 160 170 180 >>XP_016869250 (OMIM: 605030) PREDICTED: serine/threonin (403 aa) initn: 764 init1: 764 opt: 764 Z-score: 434.2 bits: 88.0 E(85289): 1.9e-17 Smith-Waterman score: 770; 83.2% identity (86.6% similar) in 149 aa overlap (1-149:1-140) 10 20 30 40 50 60 pF1KE0 MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 ESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTGFL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKT--- 70 80 90 100 110 130 140 150 160 pF1KE0 TDTTEGSASCDLRMDLTLFHLGAEFLHYLLLYEADPLSCVFSLLVFSV : . :. : : :.::.. XP_016 --LIEDEIATILKSTLK----GLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQL 120 130 140 150 160 170 >>XP_016869247 (OMIM: 605030) PREDICTED: serine/threonin (456 aa) initn: 764 init1: 764 opt: 764 Z-score: 433.7 bits: 88.1 E(85289): 2e-17 Smith-Waterman score: 770; 83.2% identity (86.6% similar) in 149 aa overlap (1-149:1-140) 10 20 30 40 50 60 pF1KE0 MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 ESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTGFL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKT--- 70 80 90 100 110 130 140 150 160 pF1KE0 TDTTEGSASCDLRMDLTLFHLGAEFLHYLLLYEADPLSCVFSLLVFSV : . :. : : :.::.. XP_016 --LIEDEIATILKSTLK----GLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQL 120 130 140 150 160 170 >>NP_006272 (OMIM: 605030) serine/threonine-protein kina (491 aa) initn: 764 init1: 764 opt: 764 Z-score: 433.4 bits: 88.1 E(85289): 2.1e-17 Smith-Waterman score: 770; 83.2% identity (86.6% similar) in 149 aa overlap (1-149:1-140) 10 20 30 40 50 60 pF1KE0 MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 ESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTGFL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 ESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKT--- 70 80 90 100 110 130 140 150 160 pF1KE0 TDTTEGSASCDLRMDLTLFHLGAEFLHYLLLYEADPLSCVFSLLVFSV : . :. : : :.::.. NP_006 --LIEDEIATILKSTLK----GLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQL 120 130 140 150 160 170 >>XP_011515553 (OMIM: 605030) PREDICTED: serine/threonin (522 aa) initn: 764 init1: 764 opt: 764 Z-score: 433.2 bits: 88.2 E(85289): 2.2e-17 Smith-Waterman score: 770; 83.2% identity (86.6% similar) in 149 aa overlap (1-149:1-140) 10 20 30 40 50 60 pF1KE0 MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 ESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTGFL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKT--- 70 80 90 100 110 130 140 150 160 pF1KE0 TDTTEGSASCDLRMDLTLFHLGAEFLHYLLLYEADPLSCVFSLLVFSV : . :. : : :.::.. XP_011 --LIEDEIATILKSTLK----GLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQL 120 130 140 150 160 170 >>XP_016869251 (OMIM: 605030) PREDICTED: serine/threonin (313 aa) initn: 703 init1: 703 opt: 703 Z-score: 403.3 bits: 81.9 E(85289): 1e-15 Smith-Waterman score: 709; 82.3% identity (85.8% similar) in 141 aa overlap (9-149:94-225) 10 20 30 pF1KE0 MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSY :::::::::::::::::::::::::::::: XP_016 SGITICLRNGAASVFKKKEWSTQGEENKQDSKLKKLSEDSLTKQPEEVFDVLEKLGEGSY 70 80 90 100 110 120 40 50 60 70 80 90 pF1KE0 GSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIV 130 140 150 160 170 180 100 110 120 130 140 150 pF1KE0 MEYCGAGSVSDIIRLRNKTGFLTDTTEGSASCDLRMDLTLFHLGAEFLHYLLLYEADPLS ::::::::::::::::::: : . :. : : :.::.. XP_016 MEYCGAGSVSDIIRLRNKT-----LIEDEIATILKSTLK----GLEYLHFMRKIHRDIKA 190 200 210 220 230 160 pF1KE0 CVFSLLVFSV XP_016 GNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGI 240 250 260 270 280 290 >>XP_011515559 (OMIM: 605030) PREDICTED: serine/threonin (313 aa) initn: 703 init1: 703 opt: 703 Z-score: 403.3 bits: 81.9 E(85289): 1e-15 Smith-Waterman score: 709; 82.3% identity (85.8% similar) in 141 aa overlap (9-149:94-225) 10 20 30 pF1KE0 MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSY :::::::::::::::::::::::::::::: XP_011 SGITICLRNGAASVFKKKEWSTQGEENKQDSKLKKLSEDSLTKQPEEVFDVLEKLGEGSY 70 80 90 100 110 120 40 50 60 70 80 90 pF1KE0 GSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIV 130 140 150 160 170 180 100 110 120 130 140 150 pF1KE0 MEYCGAGSVSDIIRLRNKTGFLTDTTEGSASCDLRMDLTLFHLGAEFLHYLLLYEADPLS ::::::::::::::::::: : . :. : : :.::.. XP_011 MEYCGAGSVSDIIRLRNKT-----LIEDEIATILKSTLK----GLEYLHFMRKIHRDIKA 190 200 210 220 230 160 pF1KE0 CVFSLLVFSV XP_011 GNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGI 240 250 260 270 280 290 >>XP_011515554 (OMIM: 605030) PREDICTED: serine/threonin (465 aa) initn: 742 init1: 704 opt: 705 Z-score: 402.7 bits: 82.4 E(85289): 1.1e-15 Smith-Waterman score: 705; 95.7% identity (97.4% similar) in 116 aa overlap (9-123:94-209) 10 20 30 pF1KE0 MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSY :::::::::::::::::::::::::::::: XP_011 SGITICLRNGAASVFKKKEWSTQGEENKQDSKLKKLSEDSLTKQPEEVFDVLEKLGEGSY 70 80 90 100 110 120 40 50 60 70 80 90 pF1KE0 GSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIV 130 140 150 160 170 180 100 110 120 130 140 150 pF1KE0 MEYCGAGSVSDIIRLRNKTG-FLTDTTEGSASCDLRMDLTLFHLGAEFLHYLLLYEADPL :::::::::::::::::::. :. : XP_011 MEYCGAGSVSDIIRLRNKTAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATA 190 200 210 220 230 240 >>NP_001243241 (OMIM: 605030) serine/threonine-protein k (519 aa) initn: 703 init1: 703 opt: 703 Z-score: 401.2 bits: 82.2 E(85289): 1.3e-15 Smith-Waterman score: 709; 82.3% identity (85.8% similar) in 141 aa overlap (9-149:37-168) 10 20 30 pF1KE0 MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSY :::::::::::::::::::::::::::::: NP_001 SGITICLRNGAASVFKKKEWSTQGEENKQDSKLKKLSEDSLTKQPEEVFDVLEKLGEGSY 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE0 GSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIV 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE0 MEYCGAGSVSDIIRLRNKTGFLTDTTEGSASCDLRMDLTLFHLGAEFLHYLLLYEADPLS ::::::::::::::::::: : . :. : : :.::.. NP_001 MEYCGAGSVSDIIRLRNKT-----LIEDEIATILKSTLK----GLEYLHFMRKIHRDIKA 130 140 150 160 170 160 pF1KE0 CVFSLLVFSV NP_001 GNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGI 180 190 200 210 220 230 >>XP_016869246 (OMIM: 605030) PREDICTED: serine/threonin (524 aa) initn: 703 init1: 703 opt: 703 Z-score: 401.2 bits: 82.2 E(85289): 1.3e-15 Smith-Waterman score: 709; 82.3% identity (85.8% similar) in 141 aa overlap (9-149:94-225) 10 20 30 pF1KE0 MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSY :::::::::::::::::::::::::::::: XP_016 SGITICLRNGAASVFKKKEWSTQGEENKQDSKLKKLSEDSLTKQPEEVFDVLEKLGEGSY 70 80 90 100 110 120 40 50 60 70 80 90 pF1KE0 GSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIV 130 140 150 160 170 180 100 110 120 130 140 150 pF1KE0 MEYCGAGSVSDIIRLRNKTGFLTDTTEGSASCDLRMDLTLFHLGAEFLHYLLLYEADPLS ::::::::::::::::::: : . :. : : :.::.. XP_016 MEYCGAGSVSDIIRLRNKT-----LIEDEIATILKSTLK----GLEYLHFMRKIHRDIKA 190 200 210 220 230 160 pF1KE0 CVFSLLVFSV XP_016 GNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGI 240 250 260 270 280 290 168 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 04:25:09 2016 done: Sat Nov 5 04:25:10 2016 Total Scan time: 5.680 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]