FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0910, 231 aa 1>>>pF1KE0910 231 - 231 aa - 231 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.4679+/-0.00038; mu= 18.4395+/- 0.023 mean_var=59.3460+/-11.973, 0's: 0 Z-trim(111.7): 21 B-trim: 18 in 1/52 Lambda= 0.166486 statistics sampled from 20364 (20376) to 20364 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.616), E-opt: 0.2 (0.239), width: 16 Scan time: 6.100 The best scores are: opt bits E(85289) NP_001305869 (OMIM: 114480,160998) ribosyldihydron ( 231) 1569 385.2 5.1e-107 NP_001277150 (OMIM: 114480,160998) ribosyldihydron ( 231) 1569 385.2 5.1e-107 NP_000895 (OMIM: 114480,160998) ribosyldihydronico ( 231) 1569 385.2 5.1e-107 NP_000894 (OMIM: 125860) NAD(P)H dehydrogenase [qu ( 274) 743 186.9 3e-47 NP_001277151 (OMIM: 114480,160998) ribosyldihydron ( 193) 657 166.1 3.9e-41 NP_001020604 (OMIM: 125860) NAD(P)H dehydrogenase ( 240) 463 119.6 4.8e-27 NP_001020605 (OMIM: 125860) NAD(P)H dehydrogenase ( 236) 315 84.0 2.4e-16 NP_001273066 (OMIM: 125860) NAD(P)H dehydrogenase ( 202) 314 83.7 2.5e-16 >>NP_001305869 (OMIM: 114480,160998) ribosyldihydronicot (231 aa) initn: 1569 init1: 1569 opt: 1569 Z-score: 2042.4 bits: 385.2 E(85289): 5.1e-107 Smith-Waterman score: 1569; 99.6% identity (100.0% similar) in 231 aa overlap (1-231:1-231) 10 20 30 40 50 60 pF1KE0 MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTL ::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::: NP_001 MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNLEPRATDKDITGTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 SNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 LCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFC 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 GFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ 190 200 210 220 230 >>NP_001277150 (OMIM: 114480,160998) ribosyldihydronicot (231 aa) initn: 1569 init1: 1569 opt: 1569 Z-score: 2042.4 bits: 385.2 E(85289): 5.1e-107 Smith-Waterman score: 1569; 99.6% identity (100.0% similar) in 231 aa overlap (1-231:1-231) 10 20 30 40 50 60 pF1KE0 MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTL ::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::: NP_001 MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNLEPRATDKDITGTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 SNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 LCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFC 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 GFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ 190 200 210 220 230 >>NP_000895 (OMIM: 114480,160998) ribosyldihydronicotina (231 aa) initn: 1569 init1: 1569 opt: 1569 Z-score: 2042.4 bits: 385.2 E(85289): 5.1e-107 Smith-Waterman score: 1569; 99.6% identity (100.0% similar) in 231 aa overlap (1-231:1-231) 10 20 30 40 50 60 pF1KE0 MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTL ::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::: NP_000 MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNLEPRATDKDITGTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 SNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 SNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 LCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFC 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 GFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 GFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ 190 200 210 220 230 >>NP_000894 (OMIM: 125860) NAD(P)H dehydrogenase [quinon (274 aa) initn: 747 init1: 722 opt: 743 Z-score: 969.2 bits: 186.9 E(85289): 3e-47 Smith-Waterman score: 743; 48.9% identity (76.5% similar) in 221 aa overlap (1-221:1-221) 10 20 30 40 50 60 pF1KE0 MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTL :.:...::: ::.: ::: ..:..:. :...: :. ::::::::.: . ::::: : NP_000 MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 SNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRV ..: :.: .:. :::. :. ::. ::::.. :::::::::: ::.::::::::..:: NP_000 KDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 LCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFC . ::. ..::.: ...: :.::.::::.. ::. :..:: .:::.: : :::: NP_000 FIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFC 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 GFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ ::.:: ::.... . . : .. .:..::..:: : :. NP_000 GFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMK 190 200 210 220 230 240 NP_000 KEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK 250 260 270 >>NP_001277151 (OMIM: 114480,160998) ribosyldihydronicot (193 aa) initn: 656 init1: 656 opt: 657 Z-score: 859.5 bits: 166.1 E(85289): 3.9e-41 Smith-Waterman score: 1199; 83.1% identity (83.5% similar) in 231 aa overlap (1-231:1-193) 10 20 30 40 50 60 pF1KE0 MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTL ::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::: NP_001 MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNLEPRATDKDITGTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 SNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRV ::::::::::::::::::::::::::::::::::::::::: NP_001 SNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQ------------------- 70 80 90 100 130 140 150 160 170 180 pF1KE0 LCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFC ::::::::::::::::::::::::::::::::::::::::: NP_001 -------------------GKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFC 110 120 130 140 190 200 210 220 230 pF1KE0 GFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ 150 160 170 180 190 >>NP_001020604 (OMIM: 125860) NAD(P)H dehydrogenase [qui (240 aa) initn: 577 init1: 442 opt: 463 Z-score: 606.5 bits: 119.6 E(85289): 4.8e-27 Smith-Waterman score: 552; 41.6% identity (64.7% similar) in 221 aa overlap (1-221:1-187) 10 20 30 40 50 60 pF1KE0 MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTL :.:...::: ::.: ::: ..:..:. :...: :. ::::::::.: . ::::: : NP_001 MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 SNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRV ..: :.: .:. :::. :. ::. ::::.. :::::::::: ::.::::::::..:: NP_001 KDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 LCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFC . ::. ..::.: :.. : :::: NP_001 FIGEFAYTYAAMYDKG----------------------------------PFRSGILHFC 130 140 190 200 210 220 230 pF1KE0 GFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ ::.:: ::.... . . : .. .:..::..:: : :. NP_001 GFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMK 150 160 170 180 190 200 NP_001 KEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK 210 220 230 240 >>NP_001020605 (OMIM: 125860) NAD(P)H dehydrogenase [qui (236 aa) initn: 597 init1: 313 opt: 315 Z-score: 414.4 bits: 84.0 E(85289): 2.4e-16 Smith-Waterman score: 509; 39.8% identity (62.9% similar) in 221 aa overlap (1-221:1-183) 10 20 30 40 50 60 pF1KE0 MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTL :.:...::: ::.: ::: ..:..:. :...: :. ::::::::.: . ::::: : NP_001 MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 SNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRV ..: :.: .:. :::. :. ::. ::::.. ::::::: NP_001 KDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQ------------------- 70 80 90 100 130 140 150 160 170 180 pF1KE0 LCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFC .: :.::.::::.. ::. :..:: .:::.: : :::: NP_001 -------------------SKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFC 110 120 130 140 190 200 210 220 230 pF1KE0 GFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ ::.:: ::.... . . : .. .:..::..:: : :. NP_001 GFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMK 150 160 170 180 190 200 NP_001 KEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK 210 220 230 >>NP_001273066 (OMIM: 125860) NAD(P)H dehydrogenase [qui (202 aa) initn: 474 init1: 314 opt: 314 Z-score: 414.0 bits: 83.7 E(85289): 2.5e-16 Smith-Waterman score: 314; 49.5% identity (74.8% similar) in 107 aa overlap (1-107:1-107) 10 20 30 40 50 60 pF1KE0 MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTL :.:...::: ::.: ::: ..:..:. :...: :. ::::::::.: . ::::: : NP_001 MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 SNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRV ..: :.: .:. :::. :. ::. ::::.. ::::::: . : NP_001 KDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQSGILHFCGFQVLEPQLTYS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 LCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFC NP_001 IGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKF 130 140 150 160 170 180 231 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 04:27:31 2016 done: Sat Nov 5 04:27:32 2016 Total Scan time: 6.100 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]