FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0914, 257 aa 1>>>pF1KE0914 257 - 257 aa - 257 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.4546+/-0.000265; mu= 5.7345+/- 0.017 mean_var=123.1957+/-24.967, 0's: 0 Z-trim(123.3): 7 B-trim: 555 in 1/58 Lambda= 0.115552 statistics sampled from 42881 (42888) to 42881 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.814), E-opt: 0.2 (0.503), width: 16 Scan time: 7.970 The best scores are: opt bits E(85289) NP_002458 (OMIM: 113970,190080) myc proto-oncogene ( 454) 1710 295.2 1.4e-79 XP_016859657 (OMIM: 164280,164840,189960) PREDICTE ( 464) 293 58.9 1.8e-08 NP_005369 (OMIM: 164280,164840,189960) N-myc proto ( 464) 293 58.9 1.8e-08 NP_001280157 (OMIM: 164280,164840,189960) N-myc pr ( 464) 293 58.9 1.8e-08 NP_005367 (OMIM: 164850) protein L-Myc isoform 2 [ ( 236) 187 41.1 0.0021 NP_001028254 (OMIM: 164850) protein L-Myc isoform ( 394) 187 41.2 0.0033 NP_001028253 (OMIM: 164850) protein L-Myc isoform ( 364) 177 39.6 0.0098 >>NP_002458 (OMIM: 113970,190080) myc proto-oncogene pro (454 aa) initn: 1710 init1: 1710 opt: 1710 Z-score: 1549.7 bits: 295.2 E(85289): 1.4e-79 Smith-Waterman score: 1710; 100.0% identity (100.0% similar) in 252 aa overlap (1-252:16-267) 10 20 30 40 pF1KE0 MPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAP ::::::::::::::::::::::::::::::::::::::::::::: NP_002 MDFFRVVENQQPPATMPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAP 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE0 SEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTEL 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE0 LGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSGSPNPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSGSPNPA 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE0 RGHSVCSTSSLYLQDLSAAASECIDPSVVFPYPLNDSSSPKSCASQDSSAFSPSSDSLLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 RGHSVCSTSSLYLQDLSAAASECIDPSVVFPYPLNDSSSPKSCASQDSSAFSPSSDSLLS 190 200 210 220 230 240 230 240 250 pF1KE0 STESSPQGSPEPLVLHEETPPTTSSDSGGTRR ::::::::::::::::::::::::::: NP_002 STESSPQGSPEPLVLHEETPPTTSSDSEEEQEDEEEIDVVSVEKRQAPGKRSESGSPSAG 250 260 270 280 290 300 >>XP_016859657 (OMIM: 164280,164840,189960) PREDICTED: N (464 aa) initn: 292 init1: 147 opt: 293 Z-score: 272.9 bits: 58.9 E(85289): 1.8e-08 Smith-Waterman score: 382; 39.0% identity (56.9% similar) in 246 aa overlap (10-235:15-232) 10 20 30 40 50 pF1KE0 MPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIWKKFEL .: ::..::.:: :: ::.. :: .: ::. ::::::::: XP_016 MPSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDD-FYFGGPDS--TPPG--EDIWKKFEL 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 LPTPPLSPSRRSGLCS---PSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVN :::::::::: . : ::.: : . : .:. : : :.. . ::: : XP_016 LPTPPLSPSRGFAEHSSEPPSWV--TEMLL--ENELWG---SPAEEDAFGLGGLGGLTPN 60 70 80 90 100 120 130 140 150 160 pF1KE0 QSFICDPDDETFIKNIIIQDCMWSGFSAAAKL---VSEKL--------ASYQAARKDSGS : .:.:::::::::: :: ::::: :. : .:. XP_016 ------P--------VILQDCMWSGFSAREKLERAVSEKLQHGRGPPTAGSTAQSPGAGA 110 120 130 140 150 170 180 190 200 210 pF1KE0 PNPA-RGHSVCS----TSSLYLQDLSAAASECIDPSVVFPYPLNDSS-SPKSCASQDSSA .:: :::. . ... .:. :.::.::.::::.:.: .: : .. : XP_016 ASPAGRGHGGAAGAGRAGAALPAELAHPAAECVDPAVVFPFPVNKREPAPVPAAPASAPA 160 170 180 190 200 210 220 230 240 250 pF1KE0 FSPSSDSLLSSTESSPQGSPEPLVLHEETPPTTSSDSGGTRR .:. : .. ..: :.: XP_016 AGPAVAS--GAGIAAPAGAPGVAPPRPGGRQTSGGDHKALSTSGEDTLSDSDDEDDEEED 220 230 240 250 260 270 >>NP_005369 (OMIM: 164280,164840,189960) N-myc proto-onc (464 aa) initn: 292 init1: 147 opt: 293 Z-score: 272.9 bits: 58.9 E(85289): 1.8e-08 Smith-Waterman score: 382; 39.0% identity (56.9% similar) in 246 aa overlap (10-235:15-232) 10 20 30 40 50 pF1KE0 MPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIWKKFEL .: ::..::.:: :: ::.. :: .: ::. ::::::::: NP_005 MPSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDD-FYFGGPDS--TPPG--EDIWKKFEL 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 LPTPPLSPSRRSGLCS---PSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVN :::::::::: . : ::.: : . : .:. : : :.. . ::: : NP_005 LPTPPLSPSRGFAEHSSEPPSWV--TEMLL--ENELWG---SPAEEDAFGLGGLGGLTPN 60 70 80 90 100 120 130 140 150 160 pF1KE0 QSFICDPDDETFIKNIIIQDCMWSGFSAAAKL---VSEKL--------ASYQAARKDSGS : .:.:::::::::: :: ::::: :. : .:. NP_005 ------P--------VILQDCMWSGFSAREKLERAVSEKLQHGRGPPTAGSTAQSPGAGA 110 120 130 140 150 170 180 190 200 210 pF1KE0 PNPA-RGHSVCS----TSSLYLQDLSAAASECIDPSVVFPYPLNDSS-SPKSCASQDSSA .:: :::. . ... .:. :.::.::.::::.:.: .: : .. : NP_005 ASPAGRGHGGAAGAGRAGAALPAELAHPAAECVDPAVVFPFPVNKREPAPVPAAPASAPA 160 170 180 190 200 210 220 230 240 250 pF1KE0 FSPSSDSLLSSTESSPQGSPEPLVLHEETPPTTSSDSGGTRR .:. : .. ..: :.: NP_005 AGPAVAS--GAGIAAPAGAPGVAPPRPGGRQTSGGDHKALSTSGEDTLSDSDDEDDEEED 220 230 240 250 260 270 >>NP_001280157 (OMIM: 164280,164840,189960) N-myc proto- (464 aa) initn: 292 init1: 147 opt: 293 Z-score: 272.9 bits: 58.9 E(85289): 1.8e-08 Smith-Waterman score: 382; 39.0% identity (56.9% similar) in 246 aa overlap (10-235:15-232) 10 20 30 40 50 pF1KE0 MPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIWKKFEL .: ::..::.:: :: ::.. :: .: ::. ::::::::: NP_001 MPSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDD-FYFGGPDS--TPPG--EDIWKKFEL 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 LPTPPLSPSRRSGLCS---PSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVN :::::::::: . : ::.: : . : .:. : : :.. . ::: : NP_001 LPTPPLSPSRGFAEHSSEPPSWV--TEMLL--ENELWG---SPAEEDAFGLGGLGGLTPN 60 70 80 90 100 120 130 140 150 160 pF1KE0 QSFICDPDDETFIKNIIIQDCMWSGFSAAAKL---VSEKL--------ASYQAARKDSGS : .:.:::::::::: :: ::::: :. : .:. NP_001 ------P--------VILQDCMWSGFSAREKLERAVSEKLQHGRGPPTAGSTAQSPGAGA 110 120 130 140 150 170 180 190 200 210 pF1KE0 PNPA-RGHSVCS----TSSLYLQDLSAAASECIDPSVVFPYPLNDSS-SPKSCASQDSSA .:: :::. . ... .:. :.::.::.::::.:.: .: : .. : NP_001 ASPAGRGHGGAAGAGRAGAALPAELAHPAAECVDPAVVFPFPVNKREPAPVPAAPASAPA 160 170 180 190 200 210 220 230 240 250 pF1KE0 FSPSSDSLLSSTESSPQGSPEPLVLHEETPPTTSSDSGGTRR .:. : .. ..: :.: NP_001 AGPAVAS--GAGIAAPAGAPGVAPPRPGGRQTSGGDHKALSTSGEDTLSDSDDEDDEEED 220 230 240 250 260 270 >>NP_005367 (OMIM: 164850) protein L-Myc isoform 2 [Homo (236 aa) initn: 258 init1: 132 opt: 187 Z-score: 182.0 bits: 41.1 E(85289): 0.0021 Smith-Waterman score: 264; 36.8% identity (51.0% similar) in 239 aa overlap (2-235:18-208) 10 20 30 40 pF1KE0 MPLNVSFT-NRNYDLDYDSVQPYFY-CDEEENFYQQQQQSELQP ::.:. ... :.:::: : ::: : :.::.. NP_005 MCVCAGCRAAPSRRGAGPLQVAGGWSEGADMDYDSYQHYFYDYDCGEDFYRST------- 10 20 30 40 50 50 60 70 80 90 100 pF1KE0 PAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMV ::::::::::::.:.:: :: :: .:. : : : . :. :.:. : NP_005 -APSEDIWKKFELVPSPPTSPPW--GL-GPG--AGDPAPGIGPPEPWPGG-CTGDEAESR 60 70 80 90 100 110 120 130 140 150 pF1KE0 TELLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKL---VSEKLASYQAARKDS . : : :: .::::::::: .: ::..:: : : NP_005 GHSKGWGRNYAS-------------IIRRDCMWSGFSARERLERAVSDRLAP-GAPR--- 110 120 130 140 160 170 180 190 200 210 pF1KE0 GSPNPARGHSVCSTSSLYLQDLSAAASECIDPSVVFPYPLNDSSSPKSCASQDSSAFSPS :.: : . : : :: : .:. . : ::.. ::. : :.. ::: NP_005 GNPPKASAAPDC-TPSL----------EAGNPAPAAPCPLGE---PKTQAC--SGSESPS 150 160 170 180 190 220 230 240 250 pF1KE0 SDSLLSSTESSPQGSPEPLVLHEETPPTTSSDSGGTRR :: . : : .: : NP_005 -DSGKDLPEPSKRGPPHGWPKLCPCLRSGIGSSQALGPSPPLFG 200 210 220 230 >>NP_001028254 (OMIM: 164850) protein L-Myc isoform 3 [H (394 aa) initn: 258 init1: 132 opt: 187 Z-score: 178.5 bits: 41.2 E(85289): 0.0033 Smith-Waterman score: 255; 32.3% identity (53.4% similar) in 251 aa overlap (2-246:18-225) 10 20 30 40 pF1KE0 MPLNVSFT-NRNYDLDYDSVQPYFY-CDEEENFYQQQQQSELQP ::.:. ... :.:::: : ::: : :.::.. NP_001 MCVCAGCRAAPSRRGAGPLQVAGGWSEGADMDYDSYQHYFYDYDCGEDFYRST------- 10 20 30 40 50 50 60 70 80 90 100 pF1KE0 PAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMV ::::::::::::.:.:: :: :: .:. : : : . :. :.:. : NP_001 -APSEDIWKKFELVPSPPTSPPW--GL-GPG--AGDPAPGIGPPEPWPGG-CTGDEAESR 60 70 80 90 100 110 120 130 140 150 pF1KE0 TELLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKL---VSEKLASYQAARKDS . : : :: .::::::::: .: ::..:: : : NP_001 GHSKGWGRNYAS-------------IIRRDCMWSGFSARERLERAVSDRLAP-GAPR--- 110 120 130 140 160 170 180 190 200 210 pF1KE0 GSPNPARGHSVCSTSSLYLQDLSAAASECIDPSVVFPYPLNDSSSPKSCASQDSSAFSPS :.: : . :. : : :. .:. . : ::.. .. ..:....: . : . NP_001 GNPPKASAAPDCTPS------LEAG-----NPAPAAPCPLGEPKT-QACSGSESPSDSEN 150 160 170 180 190 220 230 240 250 pF1KE0 SDSLLSSTESSPQ-GSPEPLVLHEETPPTTSSDSGGTRR . . ..:. . : .:... .. : NP_001 EEIDVVTVEKRQSLGIRKPVTITVRADPLDPCMKHFHISIHQQQHNYAARFPPESCSQEE 200 210 220 230 240 250 >>NP_001028253 (OMIM: 164850) protein L-Myc isoform 1 [H (364 aa) initn: 250 init1: 132 opt: 177 Z-score: 170.1 bits: 39.6 E(85289): 0.0098 Smith-Waterman score: 245; 32.8% identity (52.1% similar) in 238 aa overlap (14-246:1-195) 10 20 30 40 50 pF1KE0 MPLNVSFTNRNYDLDYDSVQPYFY-CDEEENFYQQQQQSELQPPAPSEDIWKKFELLPTP .:::: : ::: : :.::.. ::::::::::::.:.: NP_001 MDYDSYQHYFYDYDCGEDFYRS--------TAPSEDIWKKFELVPSP 10 20 30 60 70 80 90 100 110 pF1KE0 PLSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVNQSFICDP : :: :: .:. : : : . :. :.:. : . : : NP_001 PTSPPW--GL-GPG--AGDPAPGIGPPEPWPGG-CTGDEAESRGHSKGWGRNYAS----- 40 50 60 70 80 120 130 140 150 160 170 pF1KE0 DDETFIKNIIIQDCMWSGFSAAAKL---VSEKLASYQAARKDSGSPNPARGHSVCSTSSL :: .::::::::: .: ::..:: : : :.: : . : : :: NP_001 --------IIRRDCMWSGFSARERLERAVSDRLAP-GAPR---GNPPKASAAPDC-TPSL 90 100 110 120 130 180 190 200 210 220 230 pF1KE0 YLQDLSAAASECIDPSVVFPYPLNDSSSPKSCASQDSSAFSPSSDSLLSSTESSPQ-GSP : .:. . : ::.. .. ..:....: . : . . . ..:. . : NP_001 ----------EAGNPAPAAPCPLGEPKT-QACSGSESPSDSENEEIDVVTVEKRQSLGIR 140 150 160 170 180 240 250 pF1KE0 EPLVLHEETPPTTSSDSGGTRR .:... .. : NP_001 KPVTITVRADPLDPCMKHFHISIHQQQHNYAARFPPESCSQEEASERGPQEEVLERDAAG 190 200 210 220 230 240 257 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 12:07:47 2016 done: Sat Nov 5 12:07:48 2016 Total Scan time: 7.970 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]