FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0916, 287 aa 1>>>pF1KE0916 287 - 287 aa - 287 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.5239+/-0.000706; mu= 6.3070+/- 0.043 mean_var=141.3707+/-27.977, 0's: 0 Z-trim(114.9): 16 B-trim: 2 in 1/53 Lambda= 0.107868 statistics sampled from 15486 (15502) to 15486 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.804), E-opt: 0.2 (0.476), width: 16 Scan time: 2.420 The best scores are: opt bits E(32554) CCDS13463.1 PMEPA1 gene_id:56937|Hs108|chr20 ( 287) 1989 320.2 1.1e-87 CCDS13462.1 PMEPA1 gene_id:56937|Hs108|chr20 ( 252) 1741 281.5 4.2e-76 CCDS13464.1 PMEPA1 gene_id:56937|Hs108|chr20 ( 237) 1667 270.0 1.2e-72 CCDS32795.1 LDLRAD4 gene_id:753|Hs108|chr18 ( 269) 1122 185.2 4.4e-47 CCDS32793.1 LDLRAD4 gene_id:753|Hs108|chr18 ( 306) 1121 185.1 5.5e-47 CCDS62392.1 LDLRAD4 gene_id:753|Hs108|chr18 ( 229) 1047 173.5 1.3e-43 CCDS62393.1 LDLRAD4 gene_id:753|Hs108|chr18 ( 208) 890 149.0 2.6e-36 CCDS42415.1 LDLRAD4 gene_id:753|Hs108|chr18 ( 251) 854 143.5 1.5e-34 CCDS32794.1 LDLRAD4 gene_id:753|Hs108|chr18 ( 288) 854 143.5 1.7e-34 >>CCDS13463.1 PMEPA1 gene_id:56937|Hs108|chr20 (287 aa) initn: 1989 init1: 1989 opt: 1989 Z-score: 1687.5 bits: 320.2 E(32554): 1.1e-87 Smith-Waterman score: 1989; 100.0% identity (100.0% similar) in 287 aa overlap (1-287:1-287) 10 20 30 40 50 60 pF1KE0 MHRLMGVNSTAAAAAGQPNVSCTCNCKRSLFQSMEITELEFVQIIIIVVVMMVMVVVITC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 MHRLMGVNSTAAAAAGQPNVSCTCNCKRSLFQSMEITELEFVQIIIIVVVMMVMVVVITC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 LLSHYKLSARSFISRHSQGRRREDALSSEGCLWPSESTVSGNGIPEPQVYAPPRPTDRLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 LLSHYKLSARSFISRHSQGRRREDALSSEGCLWPSESTVSGNGIPEPQVYAPPRPTDRLA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 VPPFAQRERFHRFQPTYPYLQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQLELNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 VPPFAQRERFHRFQPTYPYLQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQLELNR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 ESVRAPPNRTIFDSDLMDSARLGGPCPPSSNSGISATCYGSGGRMEGPPPTYSEVIGHYP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 ESVRAPPNRTIFDSDLMDSARLGGPCPPSSNSGISATCYGSGGRMEGPPPTYSEVIGHYP 190 200 210 220 230 240 250 260 270 280 pF1KE0 GSSFQHQQSSGPPSLLEGTRLHHTHIAPLESAAIWSKEKDKQKGHPL ::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 GSSFQHQQSSGPPSLLEGTRLHHTHIAPLESAAIWSKEKDKQKGHPL 250 260 270 280 >>CCDS13462.1 PMEPA1 gene_id:56937|Hs108|chr20 (252 aa) initn: 1741 init1: 1741 opt: 1741 Z-score: 1479.8 bits: 281.5 E(32554): 4.2e-76 Smith-Waterman score: 1741; 99.2% identity (100.0% similar) in 252 aa overlap (36-287:1-252) 10 20 30 40 50 60 pF1KE0 GVNSTAAAAAGQPNVSCTCNCKRSLFQSMEITELEFVQIIIIVVVMMVMVVVITCLLSHY ..:::::::::::::::::::::::::::: CCDS13 MAELEFVQIIIIVVVMMVMVVVITCLLSHY 10 20 30 70 80 90 100 110 120 pF1KE0 KLSARSFISRHSQGRRREDALSSEGCLWPSESTVSGNGIPEPQVYAPPRPTDRLAVPPFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 KLSARSFISRHSQGRRREDALSSEGCLWPSESTVSGNGIPEPQVYAPPRPTDRLAVPPFA 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE0 QRERFHRFQPTYPYLQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQLELNRESVRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 QRERFHRFQPTYPYLQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQLELNRESVRA 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE0 PPNRTIFDSDLMDSARLGGPCPPSSNSGISATCYGSGGRMEGPPPTYSEVIGHYPGSSFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 PPNRTIFDSDLMDSARLGGPCPPSSNSGISATCYGSGGRMEGPPPTYSEVIGHYPGSSFQ 160 170 180 190 200 210 250 260 270 280 pF1KE0 HQQSSGPPSLLEGTRLHHTHIAPLESAAIWSKEKDKQKGHPL :::::::::::::::::::::::::::::::::::::::::: CCDS13 HQQSSGPPSLLEGTRLHHTHIAPLESAAIWSKEKDKQKGHPL 220 230 240 250 >>CCDS13464.1 PMEPA1 gene_id:56937|Hs108|chr20 (237 aa) initn: 1667 init1: 1667 opt: 1667 Z-score: 1417.9 bits: 270.0 E(32554): 1.2e-72 Smith-Waterman score: 1667; 100.0% identity (100.0% similar) in 237 aa overlap (51-287:1-237) 30 40 50 60 70 80 pF1KE0 SCTCNCKRSLFQSMEITELEFVQIIIIVVVMMVMVVVITCLLSHYKLSARSFISRHSQGR :::::::::::::::::::::::::::::: CCDS13 MMVMVVVITCLLSHYKLSARSFISRHSQGR 10 20 30 90 100 110 120 130 140 pF1KE0 RREDALSSEGCLWPSESTVSGNGIPEPQVYAPPRPTDRLAVPPFAQRERFHRFQPTYPYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 RREDALSSEGCLWPSESTVSGNGIPEPQVYAPPRPTDRLAVPPFAQRERFHRFQPTYPYL 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE0 QHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQLELNRESVRAPPNRTIFDSDLMDSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 QHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQLELNRESVRAPPNRTIFDSDLMDSA 100 110 120 130 140 150 210 220 230 240 250 260 pF1KE0 RLGGPCPPSSNSGISATCYGSGGRMEGPPPTYSEVIGHYPGSSFQHQQSSGPPSLLEGTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 RLGGPCPPSSNSGISATCYGSGGRMEGPPPTYSEVIGHYPGSSFQHQQSSGPPSLLEGTR 160 170 180 190 200 210 270 280 pF1KE0 LHHTHIAPLESAAIWSKEKDKQKGHPL ::::::::::::::::::::::::::: CCDS13 LHHTHIAPLESAAIWSKEKDKQKGHPL 220 230 >>CCDS32795.1 LDLRAD4 gene_id:753|Hs108|chr18 (269 aa) initn: 821 init1: 559 opt: 1122 Z-score: 958.7 bits: 185.2 E(32554): 4.4e-47 Smith-Waterman score: 1122; 65.6% identity (83.0% similar) in 259 aa overlap (28-285:17-267) 10 20 30 40 50 60 pF1KE0 MHRLMGVNSTAAAAAGQPNVSCTCNCKRSLFQSMEITELEFVQIIIIVVVMMVMVVVITC ..:: .. .::::.::::::::. ::::::.: CCDS32 MSSDHLNNSTLKEAQFKDLF--LKKAELEFAQIIIIVVVVTVMVVVIVC 10 20 30 40 70 80 90 100 110 120 pF1KE0 LLSHYKLSARSFISRHSQGRRREDALSSEGCLWPSESTVSGNGIPEPQVYAPPRPTDRLA ::.:::.:.::::.: .:.:::::.: .:::::::.:.. : : .. :: ::.. CCDS32 LLNHYKVSTRSFINRPNQSRRREDGLPQEGCLWPSDSAAPRLGASE--IMHAPRSRDRFT 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE0 VPPFAQRERFHRFQPTYPYLQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQLELNR .: : ::.:: ::::::::.:::::::::::::::::::::::::::::::::::.:::: CCDS32 APSFIQRDRFSRFQPTYPYVQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQMELNR 110 120 130 140 150 160 190 200 210 220 230 pF1KE0 ESVRAPPNRTIFDSDLMDSARL-GGPCPPSSNSGISATCYGSGGRMEGPPPTYSEVIGHY ::::::::::::::::.: : ::::::::::::::. .:.:::::::::::::.::. CCDS32 ESVRAPPNRTIFDSDLIDIAMYSGGPCPPSSNSGISASTCSSNGRMEGPPPTYSEVMGHH 170 180 190 200 210 220 240 250 260 270 280 pF1KE0 PGSSFQHQQSSGPPSLLEGTRLHHTHIAPLESAAIWSKEKDKQKGHPL ::.:: :.: :. .:.::. . ::. . : ::.. :. CCDS32 PGASFLHHQRSNAH---RGSRLQFQQNNA-ESTIVPIKGKDRKPGNLV 230 240 250 260 >>CCDS32793.1 LDLRAD4 gene_id:753|Hs108|chr18 (306 aa) initn: 821 init1: 559 opt: 1121 Z-score: 957.1 bits: 185.1 E(32554): 5.5e-47 Smith-Waterman score: 1121; 67.2% identity (83.6% similar) in 250 aa overlap (37-285:61-304) 10 20 30 40 50 60 pF1KE0 VNSTAAAAAGQPNVSCTCNCKRSLFQSMEITELEFVQIIIIVVVMMVMVVVITCLLSHYK .::::.::::::::. ::::::.:::.::: CCDS32 VCNQQNDCGDNSDEENCLLVTEHPPPGIFNSELEFAQIIIIVVVVTVMVVVIVCLLNHYK 40 50 60 70 80 90 70 80 90 100 110 120 pF1KE0 LSARSFISRHSQGRRREDALSSEGCLWPSESTVSGNGIPEPQVYAPPRPTDRLAVPPFAQ .:.::::.: .:.:::::.: .:::::::.:.. : : .. :: ::...: : : CCDS32 VSTRSFINRPNQSRRREDGLPQEGCLWPSDSAAPRLGASE--IMHAPRSRDRFTAPSFIQ 100 110 120 130 140 130 140 150 160 170 180 pF1KE0 RERFHRFQPTYPYLQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQLELNRESVRAP :.:: ::::::::.:::::::::::::::::::::::::::::::::::.:::::::::: CCDS32 RDRFSRFQPTYPYVQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQMELNRESVRAP 150 160 170 180 190 200 190 200 210 220 230 240 pF1KE0 PNRTIFDSDLMDSARL-GGPCPPSSNSGISATCYGSGGRMEGPPPTYSEVIGHYPGSSFQ ::::::::::.: : ::::::::::::::. .:.:::::::::::::.::.::.:: CCDS32 PNRTIFDSDLIDIAMYSGGPCPPSSNSGISASTCSSNGRMEGPPPTYSEVMGHHPGASFL 210 220 230 240 250 260 250 260 270 280 pF1KE0 HQQSSGPPSLLEGTRLHHTHIAPLESAAIWSKEKDKQKGHPL :.: :. .:.::. . ::. . : ::.. :. CCDS32 HHQRSNAH---RGSRLQFQQ-NNAESTIVPIKGKDRKPGNLV 270 280 290 300 >>CCDS62392.1 LDLRAD4 gene_id:753|Hs108|chr18 (229 aa) initn: 821 init1: 559 opt: 1047 Z-score: 896.7 bits: 173.5 E(32554): 1.3e-43 Smith-Waterman score: 1047; 66.5% identity (82.8% similar) in 233 aa overlap (54-285:1-227) 30 40 50 60 70 80 pF1KE0 CNCKRSLFQSMEITELEFVQIIIIVVVMMVMVVVITCLLSHYKLSARSFISRHSQGRRRE :::::.:::.:::.:.::::.: .:.:::: CCDS62 MVVVIVCLLNHYKVSTRSFINRPNQSRRRE 10 20 30 90 100 110 120 130 140 pF1KE0 DALSSEGCLWPSESTVSGNGIPEPQVYAPPRPTDRLAVPPFAQRERFHRFQPTYPYLQHE :.: .:::::::.:.. : : .. :: ::...: : ::.:: ::::::::.::: CCDS62 DGLPQEGCLWPSDSAAPRLGASE--IMHAPRSRDRFTAPSFIQRDRFSRFQPTYPYVQHE 40 50 60 70 80 150 160 170 180 190 200 pF1KE0 IDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQLELNRESVRAPPNRTIFDSDLMDSARL- ::::::::::::::::::::::::::::::::.::::::::::::::::::::.: : CCDS62 IDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQMELNRESVRAPPNRTIFDSDLIDIAMYS 90 100 110 120 130 140 210 220 230 240 250 260 pF1KE0 GGPCPPSSNSGISATCYGSGGRMEGPPPTYSEVIGHYPGSSFQHQQSSGPPSLLEGTRLH ::::::::::::::. .:.:::::::::::::.::.::.:: :.: :. .:.::. CCDS62 GGPCPPSSNSGISASTCSSNGRMEGPPPTYSEVMGHHPGASFLHHQRSNAH---RGSRLQ 150 160 170 180 190 200 270 280 pF1KE0 HTHIAPLESAAIWSKEKDKQKGHPL . ::. . : ::.. :. CCDS62 FQQ-NNAESTIVPIKGKDRKPGNLV 210 220 >>CCDS62393.1 LDLRAD4 gene_id:753|Hs108|chr18 (208 aa) initn: 821 init1: 559 opt: 890 Z-score: 765.2 bits: 149.0 E(32554): 2.6e-36 Smith-Waterman score: 890; 65.5% identity (81.0% similar) in 200 aa overlap (87-285:13-206) 60 70 80 90 100 110 pF1KE0 VITCLLSHYKLSARSFISRHSQGRRREDALSSEGCLWPSESTVSGNGIPEPQVYAPPRPT ..:::::::.:.. : : .. :: CCDS62 MRLDSHLECISSTQEGCLWPSDSAAPRLGASE--IMHAPRSR 10 20 30 40 120 130 140 150 160 170 pF1KE0 DRLAVPPFAQRERFHRFQPTYPYLQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQL ::...: : ::.:: ::::::::.:::::::::::::::::::::::::::::::::::. CCDS62 DRFTAPSFIQRDRFSRFQPTYPYVQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQM 50 60 70 80 90 100 180 190 200 210 220 230 pF1KE0 ELNRESVRAPPNRTIFDSDLMDSARL-GGPCPPSSNSGISATCYGSGGRMEGPPPTYSEV ::::::::::::::::::::.: : ::::::::::::::. .:.::::::::::::: CCDS62 ELNRESVRAPPNRTIFDSDLIDIAMYSGGPCPPSSNSGISASTCSSNGRMEGPPPTYSEV 110 120 130 140 150 160 240 250 260 270 280 pF1KE0 IGHYPGSSFQHQQSSGPPSLLEGTRLHHTHIAPLESAAIWSKEKDKQKGHPL .::.::.:: :.: :. .:.::. . ::. . : ::.. :. CCDS62 MGHHPGASFLHHQRSNAH---RGSRLQFQQ-NNAESTIVPIKGKDRKPGNLV 170 180 190 200 >>CCDS42415.1 LDLRAD4 gene_id:753|Hs108|chr18 (251 aa) initn: 1093 init1: 574 opt: 854 Z-score: 733.8 bits: 143.5 E(32554): 1.5e-34 Smith-Waterman score: 1031; 62.5% identity (78.4% similar) in 259 aa overlap (28-285:17-249) 10 20 30 40 50 60 pF1KE0 MHRLMGVNSTAAAAAGQPNVSCTCNCKRSLFQSMEITELEFVQIIIIVVVMMVMVVVITC ..:: .. .::::.::::::::. ::::::.: CCDS42 MSSDHLNNSTLKEAQFKDLF--LKKAELEFAQIIIIVVVVTVMVVVIVC 10 20 30 40 70 80 90 100 110 120 pF1KE0 LLSHYKLSARSFISRHSQGRRREDALSSEGCLWPSESTVSGNGIPEPQVYAPPRPTDRLA ::.:::.:.::::.: .:.:::::.: ::.. :: ::.. CCDS42 LLNHYKVSTRSFINRPNQSRRREDGL--------------------PQIMHAPRSRDRFT 50 60 70 80 130 140 150 160 170 180 pF1KE0 VPPFAQRERFHRFQPTYPYLQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQLELNR .: : ::.:: ::::::::.:::::::::::::::::::::::::::::::::::.:::: CCDS42 APSFIQRDRFSRFQPTYPYVQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQMELNR 90 100 110 120 130 140 190 200 210 220 230 pF1KE0 ESVRAPPNRTIFDSDLMDSARL-GGPCPPSSNSGISATCYGSGGRMEGPPPTYSEVIGHY ::::::::::::::::.: : ::::::::::::::. .:.:::::::::::::.::. CCDS42 ESVRAPPNRTIFDSDLIDIAMYSGGPCPPSSNSGISASTCSSNGRMEGPPPTYSEVMGHH 150 160 170 180 190 200 240 250 260 270 280 pF1KE0 PGSSFQHQQSSGPPSLLEGTRLHHTHIAPLESAAIWSKEKDKQKGHPL ::.:: :.: :. .:.::. . ::. . : ::.. :. CCDS42 PGASFLHHQRSNAH---RGSRLQFQQNNA-ESTIVPIKGKDRKPGNLV 210 220 230 240 250 >>CCDS32794.1 LDLRAD4 gene_id:753|Hs108|chr18 (288 aa) initn: 1094 init1: 574 opt: 854 Z-score: 732.9 bits: 143.5 E(32554): 1.7e-34 Smith-Waterman score: 1030; 64.0% identity (78.8% similar) in 250 aa overlap (37-285:61-286) 10 20 30 40 50 60 pF1KE0 VNSTAAAAAGQPNVSCTCNCKRSLFQSMEITELEFVQIIIIVVVMMVMVVVITCLLSHYK .::::.::::::::. ::::::.:::.::: CCDS32 VCNQQNDCGDNSDEENCLLVTEHPPPGIFNSELEFAQIIIIVVVVTVMVVVIVCLLNHYK 40 50 60 70 80 90 70 80 90 100 110 120 pF1KE0 LSARSFISRHSQGRRREDALSSEGCLWPSESTVSGNGIPEPQVYAPPRPTDRLAVPPFAQ .:.::::.: .:.:::::.: ::.. :: ::...: : : CCDS32 VSTRSFINRPNQSRRREDGL--------------------PQIMHAPRSRDRFTAPSFIQ 100 110 120 130 130 140 150 160 170 180 pF1KE0 RERFHRFQPTYPYLQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQLELNRESVRAP :.:: ::::::::.:::::::::::::::::::::::::::::::::::.:::::::::: CCDS32 RDRFSRFQPTYPYVQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQMELNRESVRAP 140 150 160 170 180 190 190 200 210 220 230 240 pF1KE0 PNRTIFDSDLMDSARL-GGPCPPSSNSGISATCYGSGGRMEGPPPTYSEVIGHYPGSSFQ ::::::::::.: : ::::::::::::::. .:.:::::::::::::.::.::.:: CCDS32 PNRTIFDSDLIDIAMYSGGPCPPSSNSGISASTCSSNGRMEGPPPTYSEVMGHHPGASFL 200 210 220 230 240 250 250 260 270 280 pF1KE0 HQQSSGPPSLLEGTRLHHTHIAPLESAAIWSKEKDKQKGHPL :.: :. .:.::. . ::. . : ::.. :. CCDS32 HHQRSNAH---RGSRLQFQQ-NNAESTIVPIKGKDRKPGNLV 260 270 280 287 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 04:29:35 2016 done: Sat Nov 5 04:29:35 2016 Total Scan time: 2.420 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]