FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0919, 305 aa 1>>>pF1KE0919 305 - 305 aa - 305 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.4568+/-0.000334; mu= 4.2004+/- 0.021 mean_var=207.4463+/-43.191, 0's: 0 Z-trim(122.5): 23 B-trim: 1308 in 1/60 Lambda= 0.089047 statistics sampled from 40696 (40719) to 40696 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.781), E-opt: 0.2 (0.477), width: 16 Scan time: 7.410 The best scores are: opt bits E(85289) NP_958851 (OMIM: 601714) transcriptional enhancer ( 305) 2078 278.6 1.1e-74 NP_003204 (OMIM: 601714) transcriptional enhancer ( 434) 2078 278.7 1.4e-74 NP_958849 (OMIM: 601714) transcriptional enhancer ( 391) 1881 253.4 5.4e-67 NP_068780 (OMIM: 108985,189967) transcriptional en ( 426) 1529 208.2 2.3e-53 NP_003205 (OMIM: 603170) transcriptional enhancer ( 435) 1396 191.1 3.3e-48 XP_006723491 (OMIM: 601729) PREDICTED: transcripti ( 434) 1035 144.7 3e-34 XP_011525706 (OMIM: 601729) PREDICTED: transcripti ( 441) 1024 143.3 8.2e-34 NP_001243591 (OMIM: 601729) transcriptional enhanc ( 319) 687 99.9 6.9e-21 NP_001243588 (OMIM: 601729) transcriptional enhanc ( 450) 687 100.0 8.9e-21 NP_001243587 (OMIM: 601729) transcriptional enhanc ( 450) 687 100.0 8.9e-21 XP_011525705 (OMIM: 601729) PREDICTED: transcripti ( 450) 687 100.0 8.9e-21 XP_011525701 (OMIM: 601729) PREDICTED: transcripti ( 454) 687 100.0 9e-21 XP_011525703 (OMIM: 601729) PREDICTED: transcripti ( 454) 687 100.0 9e-21 XP_011525704 (OMIM: 601729) PREDICTED: transcripti ( 454) 687 100.0 9e-21 XP_011525700 (OMIM: 601729) PREDICTED: transcripti ( 454) 687 100.0 9e-21 XP_011525702 (OMIM: 601729) PREDICTED: transcripti ( 454) 687 100.0 9e-21 XP_005259391 (OMIM: 601729) PREDICTED: transcripti ( 411) 675 98.5 2.4e-20 NP_003589 (OMIM: 601729) transcriptional enhancer ( 447) 675 98.5 2.6e-20 NP_001243590 (OMIM: 601729) transcriptional enhanc ( 451) 675 98.5 2.6e-20 XP_006723487 (OMIM: 601729) PREDICTED: transcripti ( 451) 675 98.5 2.6e-20 NP_001243589 (OMIM: 601729) transcriptional enhanc ( 451) 675 98.5 2.6e-20 XP_006723492 (OMIM: 601729) PREDICTED: transcripti ( 261) 668 97.4 3.2e-20 >>NP_958851 (OMIM: 601714) transcriptional enhancer fact (305 aa) initn: 2078 init1: 2078 opt: 2078 Z-score: 1462.0 bits: 278.6 E(85289): 1.1e-74 Smith-Waterman score: 2078; 100.0% identity (100.0% similar) in 305 aa overlap (1-305:1-305) 10 20 30 40 50 60 pF1KE0 MAAMSSAQIISATAFHSSMALARGPGRPAVSGFWQGALPGQAGTSHDVKPFSQQTYAVQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_958 MAAMSSAQIISATAFHSSMALARGPGRPAVSGFWQGALPGQAGTSHDVKPFSQQTYAVQP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 PLPLPGFESPAGPAPSPSAPPAPPWQGRSVASSKLWMLEFSAFLEQQQDPDTYNKHLFVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_958 PLPLPGFESPAGPAPSPSAPPAPPWQGRSVASSKLWMLEFSAFLEQQQDPDTYNKHLFVH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 IGQSSPSYSDPYLEAVDIRQIYDKFPEKKGGLKDLFERGPSNAFFLVKFWADLNTNIEDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_958 IGQSSPSYSDPYLEAVDIRQIYDKFPEKKGGLKDLFERGPSNAFFLVKFWADLNTNIEDE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 GSSFYGVSSQYESPENMIITCSTKVCSFGKQVVEKVETEYARYENGHYSYRIHRSPLCEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_958 GSSFYGVSSQYESPENMIITCSTKVCSFGKQVVEKVETEYARYENGHYSYRIHRSPLCEY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 MINFIHKLKHLPEKYMMNSVLENFTILQVVTNRDTQETLLCIAYVFEVSASEHGAQHHIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_958 MINFIHKLKHLPEKYMMNSVLENFTILQVVTNRDTQETLLCIAYVFEVSASEHGAQHHIY 250 260 270 280 290 300 pF1KE0 RLVKE ::::: NP_958 RLVKE >>NP_003204 (OMIM: 601714) transcriptional enhancer fact (434 aa) initn: 2078 init1: 2078 opt: 2078 Z-score: 1459.9 bits: 278.7 E(85289): 1.4e-74 Smith-Waterman score: 2078; 100.0% identity (100.0% similar) in 305 aa overlap (1-305:130-434) 10 20 30 pF1KE0 MAAMSSAQIISATAFHSSMALARGPGRPAV :::::::::::::::::::::::::::::: NP_003 SHIQVLARRKAREIQAKLKDQAAKDKALQSMAAMSSAQIISATAFHSSMALARGPGRPAV 100 110 120 130 140 150 40 50 60 70 80 90 pF1KE0 SGFWQGALPGQAGTSHDVKPFSQQTYAVQPPLPLPGFESPAGPAPSPSAPPAPPWQGRSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SGFWQGALPGQAGTSHDVKPFSQQTYAVQPPLPLPGFESPAGPAPSPSAPPAPPWQGRSV 160 170 180 190 200 210 100 110 120 130 140 150 pF1KE0 ASSKLWMLEFSAFLEQQQDPDTYNKHLFVHIGQSSPSYSDPYLEAVDIRQIYDKFPEKKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ASSKLWMLEFSAFLEQQQDPDTYNKHLFVHIGQSSPSYSDPYLEAVDIRQIYDKFPEKKG 220 230 240 250 260 270 160 170 180 190 200 210 pF1KE0 GLKDLFERGPSNAFFLVKFWADLNTNIEDEGSSFYGVSSQYESPENMIITCSTKVCSFGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GLKDLFERGPSNAFFLVKFWADLNTNIEDEGSSFYGVSSQYESPENMIITCSTKVCSFGK 280 290 300 310 320 330 220 230 240 250 260 270 pF1KE0 QVVEKVETEYARYENGHYSYRIHRSPLCEYMINFIHKLKHLPEKYMMNSVLENFTILQVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 QVVEKVETEYARYENGHYSYRIHRSPLCEYMINFIHKLKHLPEKYMMNSVLENFTILQVV 340 350 360 370 380 390 280 290 300 pF1KE0 TNRDTQETLLCIAYVFEVSASEHGAQHHIYRLVKE ::::::::::::::::::::::::::::::::::: NP_003 TNRDTQETLLCIAYVFEVSASEHGAQHHIYRLVKE 400 410 420 430 >>NP_958849 (OMIM: 601714) transcriptional enhancer fact (391 aa) initn: 1879 init1: 1879 opt: 1881 Z-score: 1323.8 bits: 253.4 E(85289): 5.4e-67 Smith-Waterman score: 1881; 96.9% identity (97.2% similar) in 287 aa overlap (21-305:105-391) 10 20 30 40 pF1KE0 MAAMSSAQIISATAFHSSMALARGPGRP--AVSGFWQGALPGQAGTSHDV ::: .: : :::::::::::::::: NP_958 YGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKAREIQAKLKFWQGALPGQAGTSHDV 80 90 100 110 120 130 50 60 70 80 90 100 pF1KE0 KPFSQQTYAVQPPLPLPGFESPAGPAPSPSAPPAPPWQGRSVASSKLWMLEFSAFLEQQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_958 KPFSQQTYAVQPPLPLPGFESPAGPAPSPSAPPAPPWQGRSVASSKLWMLEFSAFLEQQQ 140 150 160 170 180 190 110 120 130 140 150 160 pF1KE0 DPDTYNKHLFVHIGQSSPSYSDPYLEAVDIRQIYDKFPEKKGGLKDLFERGPSNAFFLVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_958 DPDTYNKHLFVHIGQSSPSYSDPYLEAVDIRQIYDKFPEKKGGLKDLFERGPSNAFFLVK 200 210 220 230 240 250 170 180 190 200 210 220 pF1KE0 FWADLNTNIEDEGSSFYGVSSQYESPENMIITCSTKVCSFGKQVVEKVETEYARYENGHY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_958 FWADLNTNIEDEGSSFYGVSSQYESPENMIITCSTKVCSFGKQVVEKVETEYARYENGHY 260 270 280 290 300 310 230 240 250 260 270 280 pF1KE0 SYRIHRSPLCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTNRDTQETLLCIAYVFEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_958 SYRIHRSPLCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTNRDTQETLLCIAYVFEV 320 330 340 350 360 370 290 300 pF1KE0 SASEHGAQHHIYRLVKE ::::::::::::::::: NP_958 SASEHGAQHHIYRLVKE 380 390 >>NP_068780 (OMIM: 108985,189967) transcriptional enhanc (426 aa) initn: 1498 init1: 1349 opt: 1529 Z-score: 1078.9 bits: 208.2 E(85289): 2.3e-53 Smith-Waterman score: 1529; 73.0% identity (88.1% similar) in 311 aa overlap (1-305:122-426) 10 20 pF1KE0 MAAMSSAQIISATAFHSSMALARG---PGR :::::::::.::::.:....: : : NP_068 SHIQVLARRKSRDFHSKLKDQTAKDKALQHMAAMSSAQIVSATAIHNKLGLP-GIPRPTF 100 110 120 130 140 150 30 40 50 60 70 80 pF1KE0 PAVSGFWQGALP-GQAGTSHDVKPFSQQTYAVQPPL--PLPGFESPAGPAPSPSAPPAPP :.. ::: : . :: :.:.::::: ::.: .:: . :.:::: ..:::: .: NP_068 PGAPGFWPGMIQTGQPGSSQDVKPFVQQAYPIQPAVTAPIPGFEPASAPAPS-----VPA 160 170 180 190 200 90 100 110 120 130 140 pF1KE0 WQGRSVASSKLWMLEFSAFLEQQQDPDTYNKHLFVHIGQSSPSYSDPYLEAVDIRQIYDK :::::....:: ..:::::::::.:::.::::::::::... ::::: ::.::::::::: NP_068 WQGRSIGTTKLRLVEFSAFLEQQRDPDSYNKHLFVHIGHANHSYSDPLLESVDIRQIYDK 210 220 230 240 250 260 150 160 170 180 190 200 pF1KE0 FPEKKGGLKDLFERGPSNAFFLVKFWADLNTNIEDEGSSFYGVSSQYESPENMIITCSTK :::::::::.:: .::.::::::::::::: ::.:....::::.::::: ::: .::::: NP_068 FPEKKGGLKELFGKGPQNAFFLVKFWADLNCNIQDDAGAFYGVTSQYESSENMTVTCSTK 270 280 290 300 310 320 210 220 230 240 250 260 pF1KE0 VCSFGKQVVEKVETEYARYENGHYSYRIHRSPLCEYMINFIHKLKHLPEKYMMNSVLENF ::::::::::::::::::.:::.. :::.:::.::::::::::::::::::::::::::: NP_068 VCSFGKQVVEKVETEYARFENGRFVYRINRSPMCEYMINFIHKLKHLPEKYMMNSVLENF 330 340 350 360 370 380 270 280 290 300 pF1KE0 TILQVVTNRDTQETLLCIAYVFEVSASEHGAQHHIYRLVKE ::: :::::::::::::.: ::::: ::::::::::::::. NP_068 TILLVVTNRDTQETLLCMACVFEVSNSEHGAQHHIYRLVKD 390 400 410 420 >>NP_003205 (OMIM: 603170) transcriptional enhancer fact (435 aa) initn: 1384 init1: 1273 opt: 1396 Z-score: 986.4 bits: 191.1 E(85289): 3.3e-48 Smith-Waterman score: 1396; 67.4% identity (85.9% similar) in 313 aa overlap (1-305:126-435) 10 20 30 pF1KE0 MAAMSSAQIISATAFHSSMALARGPGRPAV ::.::::::.::........ .: :: NP_003 VLARKKVREYQVGIKAMNLDQVSKDKALQSMASMSSAQIVSASVLQNKFS-PPSPLPQAV 100 110 120 130 140 150 40 50 60 70 80 pF1KE0 ----SGFWQGA--LPGQAGTSHDVKPFSQQTYAVQPPLP--LPGFESPAGPAPSPSAPPA : ::.. : : : :.:.:::.: .: .::::: : ..: : .: :: .: . NP_003 FSTSSRFWSSPPLLGQQPGPSQDIKPFAQPAYPIQPPLPPTLSSYE-PLAPLPSAAAS-V 160 170 180 190 200 210 90 100 110 120 130 140 pF1KE0 PPWQGRSVASSKLWMLEFSAFLEQQQDPDTYNKHLFVHIGQSSPSYSDPYLEAVDIRQIY : :: :..:::.: .::.:::.: :.:::::.:::::::::..:..::: :::::.:::: NP_003 PVWQDRTIASSRLRLLEYSAFMEVQRDPDTYSKHLFVHIGQTNPAFSDPPLEAVDVRQIY 220 230 240 250 260 270 150 160 170 180 190 200 pF1KE0 DKFPEKKGGLKDLFERGPSNAFFLVKFWADLNTNIEDEGSSFYGVSSQYESPENMIITCS :::::::::::.:.:.:: :::::::::::::..:.. ..:::::::: : ..: :. : NP_003 DKFPEKKGGLKELYEKGPPNAFFLVKFWADLNSTIQEGPGAFYGVSSQYSSADSMTISVS 280 290 300 310 320 330 210 220 230 240 250 260 pF1KE0 TKVCSFGKQVVEKVETEYARYENGHYSYRIHRSPLCEYMINFIHKLKHLPEKYMMNSVLE :::::::::::::::::::: :::.. :::::::.::::::::::::::::::::::::: NP_003 TKVCSFGKQVVEKVETEYARLENGRFVYRIHRSPMCEYMINFIHKLKHLPEKYMMNSVLE 340 350 360 370 380 390 270 280 290 300 pF1KE0 NFTILQVVTNRDTQETLLCIAYVFEVSASEHGAQHHIYRLVKE :::::::::.::.::::: ::.:::::.::::::::.:.:::. NP_003 NFTILQVVTSRDSQETLLVIAFVFEVSTSEHGAQHHVYKLVKD 400 410 420 430 >>XP_006723491 (OMIM: 601729) PREDICTED: transcriptional (434 aa) initn: 1033 init1: 463 opt: 1035 Z-score: 735.8 bits: 144.7 E(85289): 3e-34 Smith-Waterman score: 1114; 55.3% identity (75.8% similar) in 318 aa overlap (1-305:132-434) 10 20 30 pF1KE0 MAAMSSAQIISATAFHSSMALARGPGRPAV ::.:::::.::: ....... :: . XP_006 SHIQVLARRKSREIQSKLKDQVSKDKAFQTMATMSSAQLISAPSLQAKLG-PTGPQASEL 110 120 130 140 150 160 40 50 60 70 80 pF1KE0 SGFWQGALPGQAGTSHDVKPFSQQ--TYAVQPP-LPLPGFESPAGPAPSPSAPPAPP-WQ ::.:. : . ::::::: : .. :: :::.: : . .: : :.:: :: XP_006 FQFWSGG-SGPPWNVPDVKPFSQTPFTLSLTPPSTDLPGYEPPQALSPLPPPTPSPPAWQ 170 180 190 200 210 90 100 110 120 130 140 pF1KE0 GRSVASSKLWMLEFSAFLEQQQDPDTYNKHLFVHIGQSSPSYSDPYLEAVDIRQIYDKFP .:......: ..:::::.: . :.:..::::::.: :: . : ::.::.:::::::: XP_006 ARGLGTARLQLVEFSAFVEPPDAVDSYQRHLFVHISQHCPSPGAPPLESVDVRQIYDKFP 220 230 240 250 260 270 150 160 170 180 190 pF1KE0 EKKGGLKDLFERGPSNAFFLVKFWADLN--TNIEDEGSS-------FYGVSSQYESPENM ::::::..:..::: .:::::::::::: . :. :.. :::::::::: :.: XP_006 EKKGGLRELYDRGPPHAFFLVKFWADLNWGPSGEEAGAGGSISSGGFYGVSSQYESLEHM 280 290 300 310 320 330 200 210 220 230 240 250 pF1KE0 IITCSTKVCSFGKQVVEKVETEYARYENGHYSYRIHRSPLCEYMINFIHKLKHLPEKYMM .:::.: :: :. :.:.. ::. :::.:::..::.:::..:::.::: XP_006 TLTCSSK-------------TERAQLEDGRFVYRLLRSPMCEYLVNFLHKLRQLPERYMM 340 350 360 370 380 260 270 280 290 300 pF1KE0 NSVLENFTILQVVTNRDTQETLLCIAYVFEVSASEHGAQHHIYRLVKE :::::::::::::::::::: ::: :::::::.::.::::::::::.. XP_006 NSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAQHHIYRLVRD 390 400 410 420 430 >>XP_011525706 (OMIM: 601729) PREDICTED: transcriptional (441 aa) initn: 1033 init1: 463 opt: 1024 Z-score: 728.1 bits: 143.3 E(85289): 8.2e-34 Smith-Waterman score: 1103; 54.9% identity (74.4% similar) in 324 aa overlap (1-305:136-441) 10 20 30 pF1KE0 MAAMSSAQIISATAFHSSMALARGPGRPAV ::.:::::.::: ...... :: : : XP_011 VLARRKSREIQSKLKALNVDQVSKDKAFQTMATMSSAQLISAPSLQAKL----GPTGPQV 110 120 130 140 150 160 40 50 60 70 80 pF1KE0 SG------FWQGALPGQAGTSHDVKPFSQQ--TYAVQPP-LPLPGFESPAGPAPSPSAPP ::.:. : . ::::::: : .. :: :::.: : . .: : : XP_011 VQASELFQFWSGG-SGPPWNVPDVKPFSQTPFTLSLTPPSTDLPGYEPPQALSPLPPPTP 170 180 190 200 210 220 90 100 110 120 130 140 pF1KE0 APP-WQGRSVASSKLWMLEFSAFLEQQQDPDTYNKHLFVHIGQSSPSYSDPYLEAVDIRQ .:: ::.:......: ..:::::.: . :.:..::::::.: :: . : ::.::.:: XP_011 SPPAWQARGLGTARLQLVEFSAFVEPPDAVDSYQRHLFVHISQHCPSPGAPPLESVDVRQ 230 240 250 260 270 280 150 160 170 180 190 pF1KE0 IYDKFPEKKGGLKDLFERGPSNAFFLVKFWADLN--TNIEDEGSS-------FYGVSSQY ::::::::::::..:..::: .:::::::::::: . :. :.. :::::::: XP_011 IYDKFPEKKGGLRELYDRGPPHAFFLVKFWADLNWGPSGEEAGAGGSISSGGFYGVSSQY 290 300 310 320 330 340 200 210 220 230 240 250 pF1KE0 ESPENMIITCSTKVCSFGKQVVEKVETEYARYENGHYSYRIHRSPLCEYMINFIHKLKHL :: :.: .:::.: :: :. :.:.. ::. :::.:::..::.:::..: XP_011 ESLEHMTLTCSSK-------------TERAQLEDGRFVYRLLRSPMCEYLVNFLHKLRQL 350 360 370 380 260 270 280 290 300 pF1KE0 PEKYMMNSVLENFTILQVVTNRDTQETLLCIAYVFEVSASEHGAQHHIYRLVKE ::.::::::::::::::::::::::: ::: :::::::.::.::::::::::.. XP_011 PERYMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAQHHIYRLVRD 390 400 410 420 430 440 >>NP_001243591 (OMIM: 601729) transcriptional enhancer f (319 aa) initn: 1132 init1: 655 opt: 687 Z-score: 496.0 bits: 99.9 E(85289): 6.9e-21 Smith-Waterman score: 1224; 59.0% identity (78.4% similar) in 324 aa overlap (1-305:1-319) 10 20 30 40 50 pF1KE0 MAAMSSAQIISATAFHSSMALARGPGRPAVSG------FWQGALPGQAGTSHDVKPFSQQ ::.:::::.::: ...... :: : : ::.:. : . ::::::: NP_001 MATMSSAQLISAPSLQAKL----GPTGPQVVQASELFQFWSGG-SGPPWNVPDVKPFSQT 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 --TYAVQPP-LPLPGFESPAGPAPSPSAPPAPP-WQGRSVASSKLWMLEFSAFLEQQQDP : .. :: :::.: : . .: : :.:: ::.:......: ..:::::.: . NP_001 PFTLSLTPPSTDLPGYEPPQALSPLPPPTPSPPAWQARGLGTARLQLVEFSAFVEPPDAV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 DTYNKHLFVHIGQSSPSYSDPYLEAVDIRQIYDKFPEKKGGLKDLFERGPSNAFFLVKFW :.:..::::::.: :: . : ::.::.::::::::::::::..:..::: .:::::::: NP_001 DSYQRHLFVHISQHCPSPGAPPLESVDVRQIYDKFPEKKGGLRELYDRGPPHAFFLVKFW 120 130 140 150 160 170 180 190 200 210 220 pF1KE0 ADLN--TNIEDEGSS-------FYGVSSQYESPENMIITCSTKVCSFGKQVVEKVETEYA :::: . :. :.. :::::::::: :.: .:::.:::::::::::::::: : NP_001 ADLNWGPSGEEAGAGGSISSGGFYGVSSQYESLEHMTLTCSSKVCSFGKQVVEKVETERA 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE0 RYENGHYSYRIHRSPLCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTNRDTQETLLC . :.:.. ::. :::.:::..::.:::..:::.::::::::::::::::::::::: ::: NP_001 QLEDGRFVYRLLRSPMCEYLVNFLHKLRQLPERYMMNSVLENFTILQVVTNRDTQELLLC 240 250 260 270 280 290 290 300 pF1KE0 IAYVFEVSASEHGAQHHIYRLVKE :::::::.::.::::::::::.. NP_001 TAYVFEVSTSERGAQHHIYRLVRD 300 310 >>NP_001243588 (OMIM: 601729) transcriptional enhancer f (450 aa) initn: 1132 init1: 655 opt: 687 Z-score: 494.0 bits: 100.0 E(85289): 8.9e-21 Smith-Waterman score: 1224; 59.0% identity (78.4% similar) in 324 aa overlap (1-305:132-450) 10 20 30 pF1KE0 MAAMSSAQIISATAFHSSMALARGPGRPAV ::.:::::.::: ...... :: : : NP_001 SHIQVLARRKSREIQSKLKDQVSKDKAFQTMATMSSAQLISAPSLQAKL----GPTGPQV 110 120 130 140 150 40 50 60 70 80 pF1KE0 SG------FWQGALPGQAGTSHDVKPFSQQ--TYAVQPP-LPLPGFESPAGPAPSPSAPP ::.:. : . ::::::: : .. :: :::.: : . .: : : NP_001 VQASELFQFWSGG-SGPPWNVPDVKPFSQTPFTLSLTPPSTDLPGYEPPQALSPLPPPTP 160 170 180 190 200 210 90 100 110 120 130 140 pF1KE0 APP-WQGRSVASSKLWMLEFSAFLEQQQDPDTYNKHLFVHIGQSSPSYSDPYLEAVDIRQ .:: ::.:......: ..:::::.: . :.:..::::::.: :: . : ::.::.:: NP_001 SPPAWQARGLGTARLQLVEFSAFVEPPDAVDSYQRHLFVHISQHCPSPGAPPLESVDVRQ 220 230 240 250 260 270 150 160 170 180 190 pF1KE0 IYDKFPEKKGGLKDLFERGPSNAFFLVKFWADLN--TNIEDEGSS-------FYGVSSQY ::::::::::::..:..::: .:::::::::::: . :. :.. :::::::: NP_001 IYDKFPEKKGGLRELYDRGPPHAFFLVKFWADLNWGPSGEEAGAGGSISSGGFYGVSSQY 280 290 300 310 320 330 200 210 220 230 240 250 pF1KE0 ESPENMIITCSTKVCSFGKQVVEKVETEYARYENGHYSYRIHRSPLCEYMINFIHKLKHL :: :.: .:::.:::::::::::::::: :. :.:.. ::. :::.:::..::.:::..: NP_001 ESLEHMTLTCSSKVCSFGKQVVEKVETERAQLEDGRFVYRLLRSPMCEYLVNFLHKLRQL 340 350 360 370 380 390 260 270 280 290 300 pF1KE0 PEKYMMNSVLENFTILQVVTNRDTQETLLCIAYVFEVSASEHGAQHHIYRLVKE ::.::::::::::::::::::::::: ::: :::::::.::.::::::::::.. NP_001 PERYMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAQHHIYRLVRD 400 410 420 430 440 450 >>NP_001243587 (OMIM: 601729) transcriptional enhancer f (450 aa) initn: 1132 init1: 655 opt: 687 Z-score: 494.0 bits: 100.0 E(85289): 8.9e-21 Smith-Waterman score: 1224; 59.0% identity (78.4% similar) in 324 aa overlap (1-305:132-450) 10 20 30 pF1KE0 MAAMSSAQIISATAFHSSMALARGPGRPAV ::.:::::.::: ...... :: : : NP_001 SHIQVLARRKSREIQSKLKDQVSKDKAFQTMATMSSAQLISAPSLQAKL----GPTGPQV 110 120 130 140 150 40 50 60 70 80 pF1KE0 SG------FWQGALPGQAGTSHDVKPFSQQ--TYAVQPP-LPLPGFESPAGPAPSPSAPP ::.:. : . ::::::: : .. :: :::.: : . .: : : NP_001 VQASELFQFWSGG-SGPPWNVPDVKPFSQTPFTLSLTPPSTDLPGYEPPQALSPLPPPTP 160 170 180 190 200 210 90 100 110 120 130 140 pF1KE0 APP-WQGRSVASSKLWMLEFSAFLEQQQDPDTYNKHLFVHIGQSSPSYSDPYLEAVDIRQ .:: ::.:......: ..:::::.: . :.:..::::::.: :: . : ::.::.:: NP_001 SPPAWQARGLGTARLQLVEFSAFVEPPDAVDSYQRHLFVHISQHCPSPGAPPLESVDVRQ 220 230 240 250 260 270 150 160 170 180 190 pF1KE0 IYDKFPEKKGGLKDLFERGPSNAFFLVKFWADLN--TNIEDEGSS-------FYGVSSQY ::::::::::::..:..::: .:::::::::::: . :. :.. :::::::: NP_001 IYDKFPEKKGGLRELYDRGPPHAFFLVKFWADLNWGPSGEEAGAGGSISSGGFYGVSSQY 280 290 300 310 320 330 200 210 220 230 240 250 pF1KE0 ESPENMIITCSTKVCSFGKQVVEKVETEYARYENGHYSYRIHRSPLCEYMINFIHKLKHL :: :.: .:::.:::::::::::::::: :. :.:.. ::. :::.:::..::.:::..: NP_001 ESLEHMTLTCSSKVCSFGKQVVEKVETERAQLEDGRFVYRLLRSPMCEYLVNFLHKLRQL 340 350 360 370 380 390 260 270 280 290 300 pF1KE0 PEKYMMNSVLENFTILQVVTNRDTQETLLCIAYVFEVSASEHGAQHHIYRLVKE ::.::::::::::::::::::::::: ::: :::::::.::.::::::::::.. NP_001 PERYMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAQHHIYRLVRD 400 410 420 430 440 450 305 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 04:30:12 2016 done: Sat Nov 5 04:30:14 2016 Total Scan time: 7.410 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]