FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0921, 282 aa 1>>>pF1KE0921 282 - 282 aa - 282 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3485+/-0.000354; mu= 17.0837+/- 0.022 mean_var=111.8009+/-23.057, 0's: 0 Z-trim(117.1): 109 B-trim: 0 in 0/52 Lambda= 0.121297 statistics sampled from 28652 (28776) to 28652 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.716), E-opt: 0.2 (0.337), width: 16 Scan time: 7.110 The best scores are: opt bits E(85289) NP_003022 (OMIM: 602212) E3 ubiquitin-protein liga ( 282) 1978 356.5 3.2e-98 XP_006721309 (OMIM: 602212) PREDICTED: E3 ubiquiti ( 282) 1978 356.5 3.2e-98 XP_011521581 (OMIM: 602212) PREDICTED: E3 ubiquiti ( 282) 1978 356.5 3.2e-98 NP_001006611 (OMIM: 602212) E3 ubiquitin-protein l ( 313) 1978 356.6 3.4e-98 NP_005058 (OMIM: 602213) E3 ubiquitin-protein liga ( 324) 1552 282.1 9.5e-76 NP_942146 (OMIM: 615609) seven in absentia homolog ( 269) 636 121.7 1.5e-27 >>NP_003022 (OMIM: 602212) E3 ubiquitin-protein ligase S (282 aa) initn: 1978 init1: 1978 opt: 1978 Z-score: 1884.5 bits: 356.5 E(85289): 3.2e-98 Smith-Waterman score: 1978; 100.0% identity (100.0% similar) in 282 aa overlap (1-282:1-282) 10 20 30 40 50 60 pF1KE0 MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 VCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 VCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 CEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 CEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 MQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATP 190 200 210 220 230 240 250 260 270 280 pF1KE0 RSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC :::::::::::::::::::::::::::::::::::::::::: NP_003 RSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC 250 260 270 280 >>XP_006721309 (OMIM: 602212) PREDICTED: E3 ubiquitin-pr (282 aa) initn: 1978 init1: 1978 opt: 1978 Z-score: 1884.5 bits: 356.5 E(85289): 3.2e-98 Smith-Waterman score: 1978; 100.0% identity (100.0% similar) in 282 aa overlap (1-282:1-282) 10 20 30 40 50 60 pF1KE0 MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 VCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 CEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 MQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATP 190 200 210 220 230 240 250 260 270 280 pF1KE0 RSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC :::::::::::::::::::::::::::::::::::::::::: XP_006 RSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC 250 260 270 280 >>XP_011521581 (OMIM: 602212) PREDICTED: E3 ubiquitin-pr (282 aa) initn: 1978 init1: 1978 opt: 1978 Z-score: 1884.5 bits: 356.5 E(85289): 3.2e-98 Smith-Waterman score: 1978; 100.0% identity (100.0% similar) in 282 aa overlap (1-282:1-282) 10 20 30 40 50 60 pF1KE0 MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 VCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 CEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 MQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATP 190 200 210 220 230 240 250 260 270 280 pF1KE0 RSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC :::::::::::::::::::::::::::::::::::::::::: XP_011 RSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC 250 260 270 280 >>NP_001006611 (OMIM: 602212) E3 ubiquitin-protein ligas (313 aa) initn: 1978 init1: 1978 opt: 1978 Z-score: 1883.9 bits: 356.6 E(85289): 3.4e-98 Smith-Waterman score: 1978; 100.0% identity (100.0% similar) in 282 aa overlap (1-282:32-313) 10 20 30 pF1KE0 MSRQTATALPTGTSKCPPSQRVPALTGTTA :::::::::::::::::::::::::::::: NP_001 TGKATPPSLYSWRGVLFTCLPAARTRKRKEMSRQTATALPTGTSKCPPSQRVPALTGTTA 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE0 SNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLGSIRNLAMEKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLGSIRNLAMEKV 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE0 ANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLMH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLMH 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE0 QHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIVQ 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE0 LIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQLFAEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQLFAEN 250 260 270 280 290 300 280 pF1KE0 GNLGINVTISMC :::::::::::: NP_001 GNLGINVTISMC 310 >>NP_005058 (OMIM: 602213) E3 ubiquitin-protein ligase S (324 aa) initn: 1563 init1: 1243 opt: 1552 Z-score: 1480.9 bits: 282.1 E(85289): 9.5e-76 Smith-Waterman score: 1552; 77.6% identity (89.2% similar) in 286 aa overlap (5-282:37-322) 10 20 pF1KE0 MSRQTATALPTGTSKCPPSQRV---PALTG---- : .: :.: : . : :. : NP_005 TGPSANKPCSKQPPPQPQHTPSPAAPPAAATISAAGPGSSAVPAAAAVISGPGGGGGAGP 10 20 30 40 50 60 30 40 50 60 70 80 pF1KE0 TTASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLG-SIRNLA .. ....:.::::::::::::::::::::.:::::..:: ::.::::::: : :::::: NP_005 VSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKLSCCPTCRGALTPSIRNLA 70 80 90 100 110 120 90 100 110 120 130 140 pF1KE0 MEKVANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGSLDAVMP :::::..::::::::..:: .:: :::: .::..::.::::::::::::::::::.::: NP_005 MEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGSLEAVMS 130 140 150 160 170 180 150 160 170 180 190 200 pF1KE0 HLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFF :::: ::::::::::::::::::::::::::::::::::: ::::::::::::.:::::: NP_005 HLMHAHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYEGHQQFF 190 200 210 220 230 240 210 220 230 240 250 260 pF1KE0 AIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQL ::: :::::::::::::::::::.::::::::::::::.:.:.::::::::::::.::.: NP_005 AIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLVFDTAIAHL 250 260 270 280 290 300 270 280 pF1KE0 FAENGNLGINVTISMC ::.::::::::::: : NP_005 FADNGNLGINVTISTCCP 310 320 >>NP_942146 (OMIM: 615609) seven in absentia homolog 3 [ (269 aa) initn: 623 init1: 520 opt: 636 Z-score: 615.5 bits: 121.7 E(85289): 1.5e-27 Smith-Waterman score: 636; 52.3% identity (79.7% similar) in 172 aa overlap (109-280:90-258) 80 90 100 110 120 130 pF1KE0 LGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQ : : : . : . : : :: ::.:. NP_942 QGSFHPHHLSHHHCHHRHHHHLRHHAHPHHLHHQEAGLHAN--PVTPCLCMCPLFSCQWE 60 70 80 90 100 110 140 150 160 170 180 190 pF1KE0 GSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEK : :..:.::: . :. . ::: .:::::::..::. .::..:.::.: ::.:::.:::. NP_942 GRLEVVVPHLRQIHR-VDILQGAEIVFLATDMHLPAPADWIIMHSCLGHHFLLVLRKQER 120 130 140 150 160 170 200 210 220 230 240 250 pF1KE0 YDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLV ..:: :::: ..:::: ::. :.:::::: ..::: :::::::. : . ..: ..:::: NP_942 HEGHPQFFATMMLIGTPTQADCFTYRLELNRNHRRLKWEATPRSVLECVDSVITDGDCLV 180 190 200 210 220 230 260 270 280 pF1KE0 FDTSIAQLFAENGNLGINVTISMC ..::.::::..::.:.:...:. NP_942 LNTSLAQLFSDNGSLAIGIAITATEVLPSEAEM 240 250 260 282 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 07:36:05 2016 done: Sat Nov 5 07:36:06 2016 Total Scan time: 7.110 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]