Result of FASTA (omim) for
pF1KE0921
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0921, 282 aa
1>>>pF1KE0921 282 - 282 aa - 282 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.3485+/-0.000354; mu= 17.0837+/- 0.022
mean_var=111.8009+/-23.057, 0's: 0 Z-trim(117.1): 109 B-trim: 0 in 0/52
Lambda= 0.121297
statistics sampled from 28652 (28776) to 28652 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.716), E-opt: 0.2 (0.337), width: 16
Scan time: 7.110
The best scores are: opt bits E(85289)
NP_003022 (OMIM: 602212) E3 ubiquitin-protein liga ( 282) 1978 356.5 3.2e-98
XP_006721309 (OMIM: 602212) PREDICTED: E3 ubiquiti ( 282) 1978 356.5 3.2e-98
XP_011521581 (OMIM: 602212) PREDICTED: E3 ubiquiti ( 282) 1978 356.5 3.2e-98
NP_001006611 (OMIM: 602212) E3 ubiquitin-protein l ( 313) 1978 356.6 3.4e-98
NP_005058 (OMIM: 602213) E3 ubiquitin-protein liga ( 324) 1552 282.1 9.5e-76
NP_942146 (OMIM: 615609) seven in absentia homolog ( 269) 636 121.7 1.5e-27
>>NP_003022 (OMIM: 602212) E3 ubiquitin-protein ligase S (282 aa)
initn: 1978 init1: 1978 opt: 1978 Z-score: 1884.5 bits: 356.5 E(85289): 3.2e-98
Smith-Waterman score: 1978; 100.0% identity (100.0% similar) in 282 aa overlap (1-282:1-282)
10 20 30 40 50 60
pF1KE0 MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 VCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 VCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEEL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 CEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 CEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 MQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATP
190 200 210 220 230 240
250 260 270 280
pF1KE0 RSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC
::::::::::::::::::::::::::::::::::::::::::
NP_003 RSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC
250 260 270 280
>>XP_006721309 (OMIM: 602212) PREDICTED: E3 ubiquitin-pr (282 aa)
initn: 1978 init1: 1978 opt: 1978 Z-score: 1884.5 bits: 356.5 E(85289): 3.2e-98
Smith-Waterman score: 1978; 100.0% identity (100.0% similar) in 282 aa overlap (1-282:1-282)
10 20 30 40 50 60
pF1KE0 MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 VCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEEL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 CEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 MQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATP
190 200 210 220 230 240
250 260 270 280
pF1KE0 RSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC
::::::::::::::::::::::::::::::::::::::::::
XP_006 RSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC
250 260 270 280
>>XP_011521581 (OMIM: 602212) PREDICTED: E3 ubiquitin-pr (282 aa)
initn: 1978 init1: 1978 opt: 1978 Z-score: 1884.5 bits: 356.5 E(85289): 3.2e-98
Smith-Waterman score: 1978; 100.0% identity (100.0% similar) in 282 aa overlap (1-282:1-282)
10 20 30 40 50 60
pF1KE0 MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 VCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEEL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 CEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 MQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATP
190 200 210 220 230 240
250 260 270 280
pF1KE0 RSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC
::::::::::::::::::::::::::::::::::::::::::
XP_011 RSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC
250 260 270 280
>>NP_001006611 (OMIM: 602212) E3 ubiquitin-protein ligas (313 aa)
initn: 1978 init1: 1978 opt: 1978 Z-score: 1883.9 bits: 356.6 E(85289): 3.4e-98
Smith-Waterman score: 1978; 100.0% identity (100.0% similar) in 282 aa overlap (1-282:32-313)
10 20 30
pF1KE0 MSRQTATALPTGTSKCPPSQRVPALTGTTA
::::::::::::::::::::::::::::::
NP_001 TGKATPPSLYSWRGVLFTCLPAARTRKRKEMSRQTATALPTGTSKCPPSQRVPALTGTTA
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE0 SNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLGSIRNLAMEKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLGSIRNLAMEKV
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE0 ANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLMH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLMH
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE0 QHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIVQ
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE0 LIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQLFAEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQLFAEN
250 260 270 280 290 300
280
pF1KE0 GNLGINVTISMC
::::::::::::
NP_001 GNLGINVTISMC
310
>>NP_005058 (OMIM: 602213) E3 ubiquitin-protein ligase S (324 aa)
initn: 1563 init1: 1243 opt: 1552 Z-score: 1480.9 bits: 282.1 E(85289): 9.5e-76
Smith-Waterman score: 1552; 77.6% identity (89.2% similar) in 286 aa overlap (5-282:37-322)
10 20
pF1KE0 MSRQTATALPTGTSKCPPSQRV---PALTG----
: .: :.: : . : :. :
NP_005 TGPSANKPCSKQPPPQPQHTPSPAAPPAAATISAAGPGSSAVPAAAAVISGPGGGGGAGP
10 20 30 40 50 60
30 40 50 60 70 80
pF1KE0 TTASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLG-SIRNLA
.. ....:.::::::::::::::::::::.:::::..:: ::.::::::: : ::::::
NP_005 VSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKLSCCPTCRGALTPSIRNLA
70 80 90 100 110 120
90 100 110 120 130 140
pF1KE0 MEKVANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGSLDAVMP
:::::..::::::::..:: .:: :::: .::..::.::::::::::::::::::.:::
NP_005 MEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGSLEAVMS
130 140 150 160 170 180
150 160 170 180 190 200
pF1KE0 HLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFF
:::: ::::::::::::::::::::::::::::::::::: ::::::::::::.::::::
NP_005 HLMHAHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYEGHQQFF
190 200 210 220 230 240
210 220 230 240 250 260
pF1KE0 AIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQL
::: :::::::::::::::::::.::::::::::::::.:.:.::::::::::::.::.:
NP_005 AIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLVFDTAIAHL
250 260 270 280 290 300
270 280
pF1KE0 FAENGNLGINVTISMC
::.::::::::::: :
NP_005 FADNGNLGINVTISTCCP
310 320
>>NP_942146 (OMIM: 615609) seven in absentia homolog 3 [ (269 aa)
initn: 623 init1: 520 opt: 636 Z-score: 615.5 bits: 121.7 E(85289): 1.5e-27
Smith-Waterman score: 636; 52.3% identity (79.7% similar) in 172 aa overlap (109-280:90-258)
80 90 100 110 120 130
pF1KE0 LGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQ
: : : . : . : : :: ::.:.
NP_942 QGSFHPHHLSHHHCHHRHHHHLRHHAHPHHLHHQEAGLHAN--PVTPCLCMCPLFSCQWE
60 70 80 90 100 110
140 150 160 170 180 190
pF1KE0 GSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEK
: :..:.::: . :. . ::: .:::::::..::. .::..:.::.: ::.:::.:::.
NP_942 GRLEVVVPHLRQIHR-VDILQGAEIVFLATDMHLPAPADWIIMHSCLGHHFLLVLRKQER
120 130 140 150 160 170
200 210 220 230 240 250
pF1KE0 YDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLV
..:: :::: ..:::: ::. :.:::::: ..::: :::::::. : . ..: ..::::
NP_942 HEGHPQFFATMMLIGTPTQADCFTYRLELNRNHRRLKWEATPRSVLECVDSVITDGDCLV
180 190 200 210 220 230
260 270 280
pF1KE0 FDTSIAQLFAENGNLGINVTISMC
..::.::::..::.:.:...:.
NP_942 LNTSLAQLFSDNGSLAIGIAITATEVLPSEAEM
240 250 260
282 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 07:36:05 2016 done: Sat Nov 5 07:36:06 2016
Total Scan time: 7.110 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]