FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0936, 418 aa 1>>>pF1KE0936 418 - 418 aa - 418 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 12.5887+/-0.00111; mu= -10.7243+/- 0.068 mean_var=538.3911+/-110.941, 0's: 0 Z-trim(117.9): 11 B-trim: 694 in 2/54 Lambda= 0.055275 statistics sampled from 18771 (18782) to 18771 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.821), E-opt: 0.2 (0.577), width: 16 Scan time: 3.760 The best scores are: opt bits E(32554) CCDS9955.1 EVL gene_id:51466|Hs108|chr14 ( 418) 2789 236.2 4.3e-62 CCDS81851.1 EVL gene_id:51466|Hs108|chr14 ( 416) 2772 234.9 1.1e-61 CCDS33051.1 VASP gene_id:7408|Hs108|chr19 ( 380) 951 89.6 5.4e-18 CCDS31040.1 ENAH gene_id:55740|Hs108|chr1 ( 570) 694 69.3 1.1e-11 CCDS31041.1 ENAH gene_id:55740|Hs108|chr1 ( 591) 694 69.3 1.1e-11 >>CCDS9955.1 EVL gene_id:51466|Hs108|chr14 (418 aa) initn: 2789 init1: 2789 opt: 2789 Z-score: 1228.2 bits: 236.2 E(32554): 4.3e-62 Smith-Waterman score: 2789; 100.0% identity (100.0% similar) in 418 aa overlap (1-418:1-418) 10 20 30 40 50 60 pF1KE0 MATSEQSICQARASVMVYDDTSKKWVPIKPGQQGFSRINIYHNTASNTFRVVGVKLQDQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS99 MATSEQSICQARASVMVYDDTSKKWVPIKPGQQGFSRINIYHNTASNTFRVVGVKLQDQQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 VVINYSIVKGLKYNQATPTFHQWRDARQVYGLNFASKEEATTFSNAMLFALNIMNSQEGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS99 VVINYSIVKGLKYNQATPTFHQWRDARQVYGLNFASKEEATTFSNAMLFALNIMNSQEGG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 PSSQRQVQNGPSPDEMDIQRRQVMEQHQQQRQESLERRTSATGPILPPGHPSSAASAPVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS99 PSSQRQVQNGPSPDEMDIQRRQVMEQHQQQRQESLERRTSATGPILPPGHPSSAASAPVS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 CSGPPPPPPPPVPPPPTGATPPPPPPLPAGGAQGSSHDESSMSGLAAAIAGAKLRRVQRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS99 CSGPPPPPPPPVPPPPTGATPPPPPPLPAGGAQGSSHDESSMSGLAAAIAGAKLRRVQRP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 EDASGGSSPSGTSKSDANRASSGGGGGGLMEEMNKLLAKRRKAASQSDKPAEKKEDESQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS99 EDASGGSSPSGTSKSDANRASSGGGGGGLMEEMNKLLAKRRKAASQSDKPAEKKEDESQM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 EDPSTSPSPGTRAASQPPNSSEAGRKPWERSNSVEKPVSSILSRTPSVAKSPEAKSPLQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS99 EDPSTSPSPGTRAASQPPNSSEAGRKPWERSNSVEKPVSSILSRTPSVAKSPEAKSPLQS 310 320 330 340 350 360 370 380 390 400 410 pF1KE0 QPHSRMKPAGSVNDMALDAFDLDRMKQEILEEVVRELHKVKEEIIDAIRQELSGISTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS99 QPHSRMKPAGSVNDMALDAFDLDRMKQEILEEVVRELHKVKEEIIDAIRQELSGISTT 370 380 390 400 410 >>CCDS81851.1 EVL gene_id:51466|Hs108|chr14 (416 aa) initn: 2772 init1: 2772 opt: 2772 Z-score: 1220.9 bits: 234.9 E(32554): 1.1e-61 Smith-Waterman score: 2772; 100.0% identity (100.0% similar) in 415 aa overlap (4-418:2-416) 10 20 30 40 50 60 pF1KE0 MATSEQSICQARASVMVYDDTSKKWVPIKPGQQGFSRINIYHNTASNTFRVVGVKLQDQQ ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 MSEQSICQARASVMVYDDTSKKWVPIKPGQQGFSRINIYHNTASNTFRVVGVKLQDQQ 10 20 30 40 50 70 80 90 100 110 120 pF1KE0 VVINYSIVKGLKYNQATPTFHQWRDARQVYGLNFASKEEATTFSNAMLFALNIMNSQEGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 VVINYSIVKGLKYNQATPTFHQWRDARQVYGLNFASKEEATTFSNAMLFALNIMNSQEGG 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE0 PSSQRQVQNGPSPDEMDIQRRQVMEQHQQQRQESLERRTSATGPILPPGHPSSAASAPVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 PSSQRQVQNGPSPDEMDIQRRQVMEQHQQQRQESLERRTSATGPILPPGHPSSAASAPVS 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE0 CSGPPPPPPPPVPPPPTGATPPPPPPLPAGGAQGSSHDESSMSGLAAAIAGAKLRRVQRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 CSGPPPPPPPPVPPPPTGATPPPPPPLPAGGAQGSSHDESSMSGLAAAIAGAKLRRVQRP 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE0 EDASGGSSPSGTSKSDANRASSGGGGGGLMEEMNKLLAKRRKAASQSDKPAEKKEDESQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 EDASGGSSPSGTSKSDANRASSGGGGGGLMEEMNKLLAKRRKAASQSDKPAEKKEDESQM 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE0 EDPSTSPSPGTRAASQPPNSSEAGRKPWERSNSVEKPVSSILSRTPSVAKSPEAKSPLQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 EDPSTSPSPGTRAASQPPNSSEAGRKPWERSNSVEKPVSSILSRTPSVAKSPEAKSPLQS 300 310 320 330 340 350 370 380 390 400 410 pF1KE0 QPHSRMKPAGSVNDMALDAFDLDRMKQEILEEVVRELHKVKEEIIDAIRQELSGISTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 QPHSRMKPAGSVNDMALDAFDLDRMKQEILEEVVRELHKVKEEIIDAIRQELSGISTT 360 370 380 390 400 410 >>CCDS33051.1 VASP gene_id:7408|Hs108|chr19 (380 aa) initn: 338 init1: 338 opt: 951 Z-score: 436.5 bits: 89.6 E(32554): 5.4e-18 Smith-Waterman score: 1093; 48.0% identity (67.4% similar) in 427 aa overlap (4-412:2-374) 10 20 30 40 50 pF1KE0 MATSEQSICQARASVMVYDDTSKKWVPIKPGQQGFSRINIYHNTASNTFRVVGVKLQ-DQ :: ::..::.::.::: .:.:.: : :.:::..:::: ..:.::::: :.: :: CCDS33 MSETVICSSRATVMLYDDGNKRWLPAGTGPQAFSRVQIYHNPTANSFRVVGRKMQPDQ 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 QVVINYSIVKGLKYNQATPTFHQWRDARQVYGLNFASKEEATTFSNAMLFALNIMNSQEG ::::: .::.:.:::::::.::::::::::.::::.:::.:. :. .: ::. ... : CCDS33 QVVINCAIVRGVKYNQATPNFHQWRDARQVWGLNFGSKEDAAQFAAGMASALEALEG--G 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 GPSSQR-----QVQNGPSPDEMDIQRRQVMEQHQQQRQESLERRTSATGPILPPGHPSSA :: .: :::::.:.. :.:: : .: .:::.: .: ::. :... CCDS33 GPPPPPALPTWSVPNGPSPEEVEQQKRQ-----QPGPSEHIERRVSNAGG--PPAPPAGG 120 130 140 150 160 180 190 200 210 220 pF1KE0 ASAPVSCSGPPPPPPPPVPP--PPTGAT---------PPPPPPLPAGGAQGSSHDESSMS : :::::: :: :: ::.:. ::: ::::: ::: . .. CCDS33 PPPP---PGPPPPPGPPPPPGLPPSGVPAAAHGAGGGPPPAPPLPA--AQGPGGGGAGAP 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE0 GLAAAIAGAKLRRVQRPEDASGGSSPSGTSKSDANRASSG-GGGGGLMEEMNKLLAKRRK ::::::::::::.:.. :.:::: :. : .: :: .:::::::::: .::.::: CCDS33 GLAAAIAGAKLRKVSKQEEASGG--PT------APKAESGRSGGGGLMEEMNAMLARRRK 230 240 250 260 270 290 300 310 320 330 340 pF1KE0 AASQSDKPAEKKEDESQMEDPSTSPSPGTRAASQPPNSSEAGRKPWERSNSVEKPVSSIL : .: . . : :. .: : : .:. : .::. :.:::. ::. : . CCDS33 A-TQVGEKTPKDESANQEE-------PEARV----PAQSESVRRPWEK-NSTTLPR---M 280 290 300 310 320 350 360 370 380 390 400 pF1KE0 SRTPSVAKSPEAKSPLQSQPHSRMKPAGSVNDMALDAFDLDRMKQEILEEVVRELHKVKE . . ::. : ..:: . :..: : ::.:.:::.:::: .::.:::: CCDS33 KSSSSVTTS-------ETQPCT---PSSS------DYSDLQRVKQELLEEVKKELQKVKE 330 340 350 360 410 pF1KE0 EIIDAIRQELSGISTT :::.:. ::: CCDS33 EIIEAFVQELRKRGSP 370 380 >>CCDS31040.1 ENAH gene_id:55740|Hs108|chr1 (570 aa) initn: 1274 init1: 472 opt: 694 Z-score: 323.6 bits: 69.3 E(32554): 1.1e-11 Smith-Waterman score: 754; 39.2% identity (52.5% similar) in 451 aa overlap (4-272:2-447) 10 20 30 40 50 60 pF1KE0 MATSEQSICQARASVMVYDDTSKKWVPIKPGQQGFSRINIYHNTASNTFRVVGVKLQDQQ ::::::::::.::::::..::::: :. ::::..:::.:..::::::: :.::.: CCDS31 MSEQSICQARAAVMVYDDANKKWVPAG-GSTGFSRVHIYHHTGNNTFRVVGRKIQDHQ 10 20 30 40 50 70 80 90 100 110 120 pF1KE0 VVINYSIVKGLKYNQATPTFHQWRDARQVYGLNFASKEEATTFSNAMLFALNIMNSQEGG :::: .: ::::::::: ::::::::::::::::.:::.:..:..::. ::...:::: : CCDS31 VVINCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMMHALEVLNSQETG 60 70 80 90 100 110 130 140 150 pF1KE0 PSSQRQ-------VQNGPSPDEMDIQRRQVMEQHQQQ----------------------- :. :: :::::: .:..:::::..::..:. CCDS31 PTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLE 120 130 140 150 160 170 pF1KE0 ----------------------RQESLERR------------------------------ ::: :::. CCDS31 RERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLER 180 190 200 210 220 230 160 pF1KE0 ----------------------------------------------TSAT---------- .::. CCDS31 LERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAASQP 240 250 260 270 280 290 170 180 190 pF1KE0 -----------GPI-------LPPGHPSSAASA-----------PVSCSGPPPPPPPP-- ::. :::: :..:. : :. .::::::::: CCDS31 AETPSQQGIVLGPLAPPPPPPLPPG-PAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPL 300 310 320 330 340 350 200 210 220 230 240 pF1KE0 ---VPPPPTGATPPPPPPLPAGG--AQGSSHDESSMSGLAAAIAGAKLRRVQRPEDAS-- ::::: ::: :::::.: . :.:. ..::::::::::::.:.: ::.: CCDS31 PNQVPPPP---PPPPAPPLPASGFFLASMSEDNRPLTGLAAAIAGAKLRKVSRMEDTSFP 360 370 380 390 400 410 250 260 270 280 290 pF1KE0 -GGSS---PSGTSKSDANRASSGG--GGGGLMEEMNKLLAKRRKAASQSDKPAEKKEDES ::.. :..::.:..:... ::.::::: CCDS31 SGGNAIGVNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRIAEKGSTIETEQKEDK 420 430 440 450 460 470 300 310 320 330 340 350 pF1KE0 QMEDPSTSPSPGTRAASQPPNSSEAGRKPWERSNSVEKPVSSILSRTPSVAKSPEAKSPL CCDS31 GEDSEPVTSKASSTSTPEPTRKPWERTNTMNGSKSPVISRPKSTPLSQPSANGVQTEGLD 480 490 500 510 520 530 >>CCDS31041.1 ENAH gene_id:55740|Hs108|chr1 (591 aa) initn: 1274 init1: 472 opt: 694 Z-score: 323.4 bits: 69.3 E(32554): 1.1e-11 Smith-Waterman score: 754; 39.2% identity (52.5% similar) in 451 aa overlap (4-272:2-447) 10 20 30 40 50 60 pF1KE0 MATSEQSICQARASVMVYDDTSKKWVPIKPGQQGFSRINIYHNTASNTFRVVGVKLQDQQ ::::::::::.::::::..::::: :. ::::..:::.:..::::::: :.::.: CCDS31 MSEQSICQARAAVMVYDDANKKWVPAG-GSTGFSRVHIYHHTGNNTFRVVGRKIQDHQ 10 20 30 40 50 70 80 90 100 110 120 pF1KE0 VVINYSIVKGLKYNQATPTFHQWRDARQVYGLNFASKEEATTFSNAMLFALNIMNSQEGG :::: .: ::::::::: ::::::::::::::::.:::.:..:..::. ::...:::: : CCDS31 VVINCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMMHALEVLNSQETG 60 70 80 90 100 110 130 140 150 pF1KE0 PSSQRQ-------VQNGPSPDEMDIQRRQVMEQHQQQ----------------------- :. :: :::::: .:..:::::..::..:. CCDS31 PTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLE 120 130 140 150 160 170 pF1KE0 ----------------------RQESLERR------------------------------ ::: :::. CCDS31 RERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLER 180 190 200 210 220 230 160 pF1KE0 ----------------------------------------------TSAT---------- .::. CCDS31 LERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAASQP 240 250 260 270 280 290 170 180 190 pF1KE0 -----------GPI-------LPPGHPSSAASA-----------PVSCSGPPPPPPPP-- ::. :::: :..:. : :. .::::::::: CCDS31 AETPSQQGIVLGPLAPPPPPPLPPG-PAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPL 300 310 320 330 340 350 200 210 220 230 240 pF1KE0 ---VPPPPTGATPPPPPPLPAGG--AQGSSHDESSMSGLAAAIAGAKLRRVQRPEDAS-- ::::: ::: :::::.: . :.:. ..::::::::::::.:.: ::.: CCDS31 PNQVPPPP---PPPPAPPLPASGFFLASMSEDNRPLTGLAAAIAGAKLRKVSRMEDTSFP 360 370 380 390 400 410 250 260 270 280 290 pF1KE0 -GGSS---PSGTSKSDANRASSGG--GGGGLMEEMNKLLAKRRKAASQSDKPAEKKEDES ::.. :..::.:..:... ::.::::: CCDS31 SGGNAIGVNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRIAEKGSTIETEQKEDK 420 430 440 450 460 470 300 310 320 330 340 350 pF1KE0 QMEDPSTSPSPGTRAASQPPNSSEAGRKPWERSNSVEKPVSSILSRTPSVAKSPEAKSPL CCDS31 GEDSEPVTSKASSTSTPEPTRKPWERTNTMNGSKSPVISRRDSPRKNQIVFDNRSYDSLH 480 490 500 510 520 530 418 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 04:35:42 2016 done: Sat Nov 5 04:35:43 2016 Total Scan time: 3.760 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]