FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0936, 418 aa 1>>>pF1KE0936 418 - 418 aa - 418 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 14.0368+/-0.000421; mu= -19.2614+/- 0.026 mean_var=624.7168+/-126.073, 0's: 0 Z-trim(126.0): 27 B-trim: 0 in 0/59 Lambda= 0.051314 statistics sampled from 50890 (50920) to 50890 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.832), E-opt: 0.2 (0.597), width: 16 Scan time: 10.420 The best scores are: opt bits E(85289) NP_057421 (OMIM: 616912) ena/VASP-like protein iso ( 418) 2789 220.6 5.8e-57 NP_001317150 (OMIM: 616912) ena/VASP-like protein ( 416) 2772 219.4 1.4e-56 XP_005267806 (OMIM: 616912) PREDICTED: ena/VASP-li ( 422) 2772 219.4 1.4e-56 XP_016876852 (OMIM: 616912) PREDICTED: ena/VASP-li ( 429) 2054 166.2 1.4e-40 XP_011535130 (OMIM: 616912) PREDICTED: ena/VASP-li ( 370) 2051 165.9 1.5e-40 XP_005259257 (OMIM: 601703) PREDICTED: vasodilator ( 379) 955 84.8 4e-16 NP_003361 (OMIM: 601703) vasodilator-stimulated ph ( 380) 951 84.5 4.9e-16 XP_005259256 (OMIM: 601703) PREDICTED: vasodilator ( 379) 940 83.7 8.6e-16 XP_016882689 (OMIM: 601703) PREDICTED: vasodilator ( 378) 935 83.3 1.1e-15 XP_005273244 (OMIM: 609061) PREDICTED: protein ena ( 605) 697 65.9 3.1e-10 NP_060682 (OMIM: 609061) protein enabled homolog i ( 570) 694 65.6 3.5e-10 NP_001008493 (OMIM: 609061) protein enabled homolo ( 591) 694 65.7 3.6e-10 XP_016857241 (OMIM: 609061) PREDICTED: protein ena ( 795) 694 65.8 4.5e-10 XP_016857240 (OMIM: 609061) PREDICTED: protein ena ( 832) 694 65.8 4.6e-10 XP_016857237 (OMIM: 609061) PREDICTED: protein ena ( 853) 694 65.8 4.7e-10 XP_016857246 (OMIM: 609061) PREDICTED: protein ena ( 578) 623 60.4 1.4e-08 XP_016857245 (OMIM: 609061) PREDICTED: protein ena ( 578) 623 60.4 1.4e-08 XP_016857242 (OMIM: 609061) PREDICTED: protein ena ( 628) 575 56.9 1.7e-07 XP_016857243 (OMIM: 609061) PREDICTED: protein ena ( 614) 572 56.6 1.9e-07 XP_016857239 (OMIM: 609061) PREDICTED: protein ena ( 839) 572 56.8 2.4e-07 XP_016857238 (OMIM: 609061) PREDICTED: protein ena ( 851) 572 56.8 2.5e-07 XP_016857236 (OMIM: 609061) PREDICTED: protein ena ( 855) 572 56.8 2.5e-07 XP_011542531 (OMIM: 609061) PREDICTED: protein ena ( 872) 572 56.8 2.5e-07 XP_016857235 (OMIM: 609061) PREDICTED: protein ena ( 876) 572 56.8 2.5e-07 XP_016857244 (OMIM: 609061) PREDICTED: protein ena ( 601) 501 51.4 7.3e-06 >>NP_057421 (OMIM: 616912) ena/VASP-like protein isoform (418 aa) initn: 2789 init1: 2789 opt: 2789 Z-score: 1143.7 bits: 220.6 E(85289): 5.8e-57 Smith-Waterman score: 2789; 100.0% identity (100.0% similar) in 418 aa overlap (1-418:1-418) 10 20 30 40 50 60 pF1KE0 MATSEQSICQARASVMVYDDTSKKWVPIKPGQQGFSRINIYHNTASNTFRVVGVKLQDQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 MATSEQSICQARASVMVYDDTSKKWVPIKPGQQGFSRINIYHNTASNTFRVVGVKLQDQQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 VVINYSIVKGLKYNQATPTFHQWRDARQVYGLNFASKEEATTFSNAMLFALNIMNSQEGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 VVINYSIVKGLKYNQATPTFHQWRDARQVYGLNFASKEEATTFSNAMLFALNIMNSQEGG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 PSSQRQVQNGPSPDEMDIQRRQVMEQHQQQRQESLERRTSATGPILPPGHPSSAASAPVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 PSSQRQVQNGPSPDEMDIQRRQVMEQHQQQRQESLERRTSATGPILPPGHPSSAASAPVS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 CSGPPPPPPPPVPPPPTGATPPPPPPLPAGGAQGSSHDESSMSGLAAAIAGAKLRRVQRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 CSGPPPPPPPPVPPPPTGATPPPPPPLPAGGAQGSSHDESSMSGLAAAIAGAKLRRVQRP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 EDASGGSSPSGTSKSDANRASSGGGGGGLMEEMNKLLAKRRKAASQSDKPAEKKEDESQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 EDASGGSSPSGTSKSDANRASSGGGGGGLMEEMNKLLAKRRKAASQSDKPAEKKEDESQM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 EDPSTSPSPGTRAASQPPNSSEAGRKPWERSNSVEKPVSSILSRTPSVAKSPEAKSPLQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 EDPSTSPSPGTRAASQPPNSSEAGRKPWERSNSVEKPVSSILSRTPSVAKSPEAKSPLQS 310 320 330 340 350 360 370 380 390 400 410 pF1KE0 QPHSRMKPAGSVNDMALDAFDLDRMKQEILEEVVRELHKVKEEIIDAIRQELSGISTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 QPHSRMKPAGSVNDMALDAFDLDRMKQEILEEVVRELHKVKEEIIDAIRQELSGISTT 370 380 390 400 410 >>NP_001317150 (OMIM: 616912) ena/VASP-like protein isof (416 aa) initn: 2772 init1: 2772 opt: 2772 Z-score: 1136.9 bits: 219.4 E(85289): 1.4e-56 Smith-Waterman score: 2772; 100.0% identity (100.0% similar) in 415 aa overlap (4-418:2-416) 10 20 30 40 50 60 pF1KE0 MATSEQSICQARASVMVYDDTSKKWVPIKPGQQGFSRINIYHNTASNTFRVVGVKLQDQQ ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSEQSICQARASVMVYDDTSKKWVPIKPGQQGFSRINIYHNTASNTFRVVGVKLQDQQ 10 20 30 40 50 70 80 90 100 110 120 pF1KE0 VVINYSIVKGLKYNQATPTFHQWRDARQVYGLNFASKEEATTFSNAMLFALNIMNSQEGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVINYSIVKGLKYNQATPTFHQWRDARQVYGLNFASKEEATTFSNAMLFALNIMNSQEGG 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE0 PSSQRQVQNGPSPDEMDIQRRQVMEQHQQQRQESLERRTSATGPILPPGHPSSAASAPVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSSQRQVQNGPSPDEMDIQRRQVMEQHQQQRQESLERRTSATGPILPPGHPSSAASAPVS 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE0 CSGPPPPPPPPVPPPPTGATPPPPPPLPAGGAQGSSHDESSMSGLAAAIAGAKLRRVQRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CSGPPPPPPPPVPPPPTGATPPPPPPLPAGGAQGSSHDESSMSGLAAAIAGAKLRRVQRP 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE0 EDASGGSSPSGTSKSDANRASSGGGGGGLMEEMNKLLAKRRKAASQSDKPAEKKEDESQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDASGGSSPSGTSKSDANRASSGGGGGGLMEEMNKLLAKRRKAASQSDKPAEKKEDESQM 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE0 EDPSTSPSPGTRAASQPPNSSEAGRKPWERSNSVEKPVSSILSRTPSVAKSPEAKSPLQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDPSTSPSPGTRAASQPPNSSEAGRKPWERSNSVEKPVSSILSRTPSVAKSPEAKSPLQS 300 310 320 330 340 350 370 380 390 400 410 pF1KE0 QPHSRMKPAGSVNDMALDAFDLDRMKQEILEEVVRELHKVKEEIIDAIRQELSGISTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QPHSRMKPAGSVNDMALDAFDLDRMKQEILEEVVRELHKVKEEIIDAIRQELSGISTT 360 370 380 390 400 410 >>XP_005267806 (OMIM: 616912) PREDICTED: ena/VASP-like p (422 aa) initn: 2772 init1: 2772 opt: 2772 Z-score: 1136.8 bits: 219.4 E(85289): 1.4e-56 Smith-Waterman score: 2772; 100.0% identity (100.0% similar) in 415 aa overlap (4-418:8-422) 10 20 30 40 50 pF1KE0 MATSEQSICQARASVMVYDDTSKKWVPIKPGQQGFSRINIYHNTASNTFRVVGVKL ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MFAFEEFSEQSICQARASVMVYDDTSKKWVPIKPGQQGFSRINIYHNTASNTFRVVGVKL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 QDQQVVINYSIVKGLKYNQATPTFHQWRDARQVYGLNFASKEEATTFSNAMLFALNIMNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QDQQVVINYSIVKGLKYNQATPTFHQWRDARQVYGLNFASKEEATTFSNAMLFALNIMNS 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 QEGGPSSQRQVQNGPSPDEMDIQRRQVMEQHQQQRQESLERRTSATGPILPPGHPSSAAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QEGGPSSQRQVQNGPSPDEMDIQRRQVMEQHQQQRQESLERRTSATGPILPPGHPSSAAS 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE0 APVSCSGPPPPPPPPVPPPPTGATPPPPPPLPAGGAQGSSHDESSMSGLAAAIAGAKLRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 APVSCSGPPPPPPPPVPPPPTGATPPPPPPLPAGGAQGSSHDESSMSGLAAAIAGAKLRR 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE0 VQRPEDASGGSSPSGTSKSDANRASSGGGGGGLMEEMNKLLAKRRKAASQSDKPAEKKED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VQRPEDASGGSSPSGTSKSDANRASSGGGGGGLMEEMNKLLAKRRKAASQSDKPAEKKED 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE0 ESQMEDPSTSPSPGTRAASQPPNSSEAGRKPWERSNSVEKPVSSILSRTPSVAKSPEAKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ESQMEDPSTSPSPGTRAASQPPNSSEAGRKPWERSNSVEKPVSSILSRTPSVAKSPEAKS 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE0 PLQSQPHSRMKPAGSVNDMALDAFDLDRMKQEILEEVVRELHKVKEEIIDAIRQELSGIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PLQSQPHSRMKPAGSVNDMALDAFDLDRMKQEILEEVVRELHKVKEEIIDAIRQELSGIS 370 380 390 400 410 420 pF1KE0 TT :: XP_005 TT >>XP_016876852 (OMIM: 616912) PREDICTED: ena/VASP-like p (429 aa) initn: 2193 init1: 2018 opt: 2054 Z-score: 849.5 bits: 166.2 E(85289): 1.4e-40 Smith-Waterman score: 2064; 84.5% identity (90.6% similar) in 373 aa overlap (4-371:8-368) 10 20 30 40 50 pF1KE0 MATSEQSICQARASVMVYDDTSKKWVPIKPGQQGFSRINIYHNTASNTFRVVGVKL ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MFAFEEFSEQSICQARASVMVYDDTSKKWVPIKPGQQGFSRINIYHNTASNTFRVVGVKL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 QDQQVVINYSIVKGLKYNQATPTFHQWRDARQVYGLNFASKEEATTFSNAMLFALNIMNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QDQQVVINYSIVKGLKYNQATPTFHQWRDARQVYGLNFASKEEATTFSNAMLFALNIMNS 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 QEGGPSSQRQVQNGPSPDEMDIQRRQVMEQHQQQRQESLERRTSATGPILPPGHPSSAAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QEGGPSSQRQVQNGPSPDEMDIQRRQVMEQHQQQRQESLERRTSATGPILPPGHPSSAAS 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE0 APVSCSGPPPPPPPPVPPPPTGATPPPPPPLPAGGAQGSSHDESSMSGLAAAIAGAKLRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APVSCSGPPPPPPPPVPPPPTGATPPPPPPLPAGGAQGSSHDESSMSGLAAAIAGAKLRR 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE0 VQRPEDASGGSSPSGTSKSDANRASSGGGGGGLMEEMNKLLAKRRKAASQSDKPAEKKED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VQRPEDASGGSSPSGTSKSDANRASSGGGGGGLMEEMNKLLAKRRKAASQSDKPAEKKED 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE0 ESQMEDPSTSPSPGTRAASQPPNSSEAGRKPWERSNSVEKPVSSILSRTP--SVAKSPEA :::: . .::. ..:: ..:. :. ..... .: .:.: .. : XP_016 ESQMGYLAFPGAPGS--TDQP-----GSRRDWDSRSTLQRGTS---ARSPERKILVPPPL 310 320 330 340 350 360 370 380 390 400 410 pF1KE0 KSPLQSQPHSRMKP---AGSVNDMALDAFDLDRMKQEILEEVVRELHKVKEEIIDAIRQE ..: :: :.. : ::: XP_016 RGP--EQPASHLTPQRLAGSPGSGATRWRSLCPRFCPEPRLWQRAPKLRAPFSRSLTLGT 360 370 380 390 400 >>XP_011535130 (OMIM: 616912) PREDICTED: ena/VASP-like p (370 aa) initn: 2333 init1: 2018 opt: 2051 Z-score: 849.1 bits: 165.9 E(85289): 1.5e-40 Smith-Waterman score: 2051; 84.5% identity (90.8% similar) in 368 aa overlap (4-370:8-368) 10 20 30 40 50 pF1KE0 MATSEQSICQARASVMVYDDTSKKWVPIKPGQQGFSRINIYHNTASNTFRVVGVKL ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MFAFEEFSEQSICQARASVMVYDDTSKKWVPIKPGQQGFSRINIYHNTASNTFRVVGVKL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 QDQQVVINYSIVKGLKYNQATPTFHQWRDARQVYGLNFASKEEATTFSNAMLFALNIMNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QDQQVVINYSIVKGLKYNQATPTFHQWRDARQVYGLNFASKEEATTFSNAMLFALNIMNS 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 QEGGPSSQRQVQNGPSPDEMDIQRRQVMEQHQQQRQESLERRTSATGPILPPGHPSSAAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QEGGPSSQRQVQNGPSPDEMDIQRRQVMEQHQQQRQESLERRTSATGPILPPGHPSSAAS 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE0 APVSCSGPPPPPPPPVPPPPTGATPPPPPPLPAGGAQGSSHDESSMSGLAAAIAGAKLRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 APVSCSGPPPPPPPPVPPPPTGATPPPPPPLPAGGAQGSSHDESSMSGLAAAIAGAKLRR 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE0 VQRPEDASGGSSPSGTSKSDANRASSGGGGGGLMEEMNKLLAKRRKAASQSDKPAEKKED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VQRPEDASGGSSPSGTSKSDANRASSGGGGGGLMEEMNKLLAKRRKAASQSDKPAEKKED 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE0 ESQMEDPSTSPSPGTRAASQPPNSSEAGRKPWERSNSVEKPVSSILSRTP-SVAKSPEAK :::: . .::. ..:: ..:. :. ..... .:. . : . . .. XP_011 ESQMGYLAFPGAPGS--TDQP-----GSRRDWDSRSTLQRGTSARSPERPRDNHRHQNTV 310 320 330 340 350 360 370 380 390 400 410 pF1KE0 SPLQSQPHSRMKPAGSVNDMALDAFDLDRMKQEILEEVVRELHKVKEEIIDAIRQELSGI . :: :: . :: XP_011 ASLQPQPWGSEDIAGLS 360 370 >>XP_005259257 (OMIM: 601703) PREDICTED: vasodilator-sti (379 aa) initn: 626 init1: 338 opt: 955 Z-score: 410.5 bits: 84.8 E(85289): 4e-16 Smith-Waterman score: 1096; 47.8% identity (67.4% similar) in 427 aa overlap (4-412:2-373) 10 20 30 40 50 pF1KE0 MATSEQSICQARASVMVYDDTSKKWVPIKPGQQGFSRINIYHNTASNTFRVVGVKLQ-DQ :: ::..::.::.::: .:.:.: : :.:::..:::: ..:.::::: :.: :: XP_005 MSETVICSSRATVMLYDDGNKRWLPAGTGPQAFSRVQIYHNPTANSFRVVGRKMQPDQ 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 QVVINYSIVKGLKYNQATPTFHQWRDARQVYGLNFASKEEATTFSNAMLFALNIMNSQEG ::::: .::.:.:::::::.::::::::::.::::.:::.:. :. .: ::. ... : XP_005 QVVINCAIVRGVKYNQATPNFHQWRDARQVWGLNFGSKEDAAQFAAGMASALEALEG--G 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 GPSSQR-----QVQNGPSPDEMDIQRRQVMEQHQQQRQESLERRTSATGPILPPGHPSSA :: .: :::::.:.. :.:: : .: .:::.: .: ::. :... XP_005 GPPPPPALPTWSVPNGPSPEEVEQQKRQ-----QPGPSEHIERRVSNAGG--PPAPPAGG 120 130 140 150 160 180 190 200 210 220 pF1KE0 ASAPVSCSGPPPPPPPPVPP--PPTGAT---------PPPPPPLPAGGAQGSSHDESSMS : :::::: :: :: ::.:. ::: ::::: ::: . .. XP_005 PPPP---PGPPPPPGPPPPPGLPPSGVPAAAHGAGGGPPPAPPLPA--AQGPGGGGAGAP 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE0 GLAAAIAGAKLRRVQRPEDASGGSSPSGTSKSDANRASSG-GGGGGLMEEMNKLLAKRRK ::::::::::::.:.. :.:::: :. : .: :: .:::::::::: .::.::: XP_005 GLAAAIAGAKLRKVSKQEEASGG--PT------APKAESGRSGGGGLMEEMNAMLARRRK 230 240 250 260 270 290 300 310 320 330 340 pF1KE0 AASQSDKPAEKKEDESQMEDPSTSPSPGTRAASQPPNSSEAGRKPWERSNSVEKPVSSIL :.. ..: . ::: :.: .. : .::. :.:::. ::. : . XP_005 ATQVGEKTPK---DESANEEPE----------ARVPAQSESVRRPWEK-NSTTLPR---M 280 290 300 310 350 360 370 380 390 400 pF1KE0 SRTPSVAKSPEAKSPLQSQPHSRMKPAGSVNDMALDAFDLDRMKQEILEEVVRELHKVKE . . ::. : ..:: . :..: : ::.:.:::.:::: .::.:::: XP_005 KSSSSVTTS-------ETQPCT---PSSS------DYSDLQRVKQELLEEVKKELQKVKE 320 330 340 350 360 410 pF1KE0 EIIDAIRQELSGISTT :::.:. ::: XP_005 EIIEAFVQELRKRGSP 370 >>NP_003361 (OMIM: 601703) vasodilator-stimulated phosph (380 aa) initn: 338 init1: 338 opt: 951 Z-score: 408.9 bits: 84.5 E(85289): 4.9e-16 Smith-Waterman score: 1093; 48.0% identity (67.4% similar) in 427 aa overlap (4-412:2-374) 10 20 30 40 50 pF1KE0 MATSEQSICQARASVMVYDDTSKKWVPIKPGQQGFSRINIYHNTASNTFRVVGVKLQ-DQ :: ::..::.::.::: .:.:.: : :.:::..:::: ..:.::::: :.: :: NP_003 MSETVICSSRATVMLYDDGNKRWLPAGTGPQAFSRVQIYHNPTANSFRVVGRKMQPDQ 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 QVVINYSIVKGLKYNQATPTFHQWRDARQVYGLNFASKEEATTFSNAMLFALNIMNSQEG ::::: .::.:.:::::::.::::::::::.::::.:::.:. :. .: ::. ... : NP_003 QVVINCAIVRGVKYNQATPNFHQWRDARQVWGLNFGSKEDAAQFAAGMASALEALEG--G 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 GPSSQR-----QVQNGPSPDEMDIQRRQVMEQHQQQRQESLERRTSATGPILPPGHPSSA :: .: :::::.:.. :.:: : .: .:::.: .: ::. :... NP_003 GPPPPPALPTWSVPNGPSPEEVEQQKRQ-----QPGPSEHIERRVSNAGG--PPAPPAGG 120 130 140 150 160 180 190 200 210 220 pF1KE0 ASAPVSCSGPPPPPPPPVPP--PPTGAT---------PPPPPPLPAGGAQGSSHDESSMS : :::::: :: :: ::.:. ::: ::::: ::: . .. NP_003 PPPP---PGPPPPPGPPPPPGLPPSGVPAAAHGAGGGPPPAPPLPA--AQGPGGGGAGAP 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE0 GLAAAIAGAKLRRVQRPEDASGGSSPSGTSKSDANRASSG-GGGGGLMEEMNKLLAKRRK ::::::::::::.:.. :.:::: :. : .: :: .:::::::::: .::.::: NP_003 GLAAAIAGAKLRKVSKQEEASGG--PT------APKAESGRSGGGGLMEEMNAMLARRRK 230 240 250 260 270 290 300 310 320 330 340 pF1KE0 AASQSDKPAEKKEDESQMEDPSTSPSPGTRAASQPPNSSEAGRKPWERSNSVEKPVSSIL : .: . . : :. .: : : .:. : .::. :.:::. ::. : . NP_003 A-TQVGEKTPKDESANQEE-------PEARV----PAQSESVRRPWEK-NSTTLPR---M 280 290 300 310 320 350 360 370 380 390 400 pF1KE0 SRTPSVAKSPEAKSPLQSQPHSRMKPAGSVNDMALDAFDLDRMKQEILEEVVRELHKVKE . . ::. : ..:: . :..: : ::.:.:::.:::: .::.:::: NP_003 KSSSSVTTS-------ETQPCT---PSSS------DYSDLQRVKQELLEEVKKELQKVKE 330 340 350 360 410 pF1KE0 EIIDAIRQELSGISTT :::.:. ::: NP_003 EIIEAFVQELRKRGSP 370 380 >>XP_005259256 (OMIM: 601703) PREDICTED: vasodilator-sti (379 aa) initn: 660 init1: 338 opt: 940 Z-score: 404.5 bits: 83.7 E(85289): 8.6e-16 Smith-Waterman score: 1082; 48.0% identity (67.4% similar) in 427 aa overlap (4-412:2-373) 10 20 30 40 50 pF1KE0 MATSEQSICQARASVMVYDDTSKKWVPIKPGQQGFSRINIYHNTASNTFRVVGVKLQ-DQ :: ::..::.::.::: .:.:.: : :.:::..:::: ..:.::::: :.: :: XP_005 MSETVICSSRATVMLYDDGNKRWLPAGTGPQAFSRVQIYHNPTANSFRVVGRKMQPDQ 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 QVVINYSIVKGLKYNQATPTFHQWRDARQVYGLNFASKEEATTFSNAMLFALNIMNSQEG ::::: .::.:.:::::::.::::::::::.::::.:::.:. :. .: ::. ... : XP_005 QVVINCAIVRGVKYNQATPNFHQWRDARQVWGLNFGSKEDAAQFAAGMASALEALEG--G 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 GPSSQR-----QVQNGPSPDEMDIQRRQVMEQHQQQRQESLERRTSATGPILPPGHPSSA :: .: :::::.:.. :.:: : .: .:::.: .: ::. :... XP_005 GPPPPPALPTWSVPNGPSPEEVEQQKRQ-----QPGPSEHIERRVSNAGG--PPAPPAGG 120 130 140 150 160 180 190 200 210 220 pF1KE0 ASAPVSCSGPPPPPPPPVPP--PPTGAT---------PPPPPPLPAGGAQGSSHDESSMS : :::::: :: :: ::.:. ::: ::::: ::: . .. XP_005 PPPP---PGPPPPPGPPPPPGLPPSGVPAAAHGAGGGPPPAPPLPA--AQGPGGGGAGAP 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE0 GLAAAIAGAKLRRVQRPEDASGGSSPSGTSKSDANRASSG-GGGGGLMEEMNKLLAKRRK ::::::::::::.:.. :.:::: :. : .: :: .:::::::::: .::.::: XP_005 GLAAAIAGAKLRKVSK-EEASGG--PT------APKAESGRSGGGGLMEEMNAMLARRRK 230 240 250 260 270 290 300 310 320 330 340 pF1KE0 AASQSDKPAEKKEDESQMEDPSTSPSPGTRAASQPPNSSEAGRKPWERSNSVEKPVSSIL : .: . . : :. .: : : .:. : .::. :.:::. ::. : . XP_005 A-TQVGEKTPKDESANQEE-------PEARV----PAQSESVRRPWEK-NSTTLPR---M 280 290 300 310 350 360 370 380 390 400 pF1KE0 SRTPSVAKSPEAKSPLQSQPHSRMKPAGSVNDMALDAFDLDRMKQEILEEVVRELHKVKE . . ::. : ..:: . :..: : ::.:.:::.:::: .::.:::: XP_005 KSSSSVTTS-------ETQPCT---PSSS------DYSDLQRVKQELLEEVKKELQKVKE 320 330 340 350 360 410 pF1KE0 EIIDAIRQELSGISTT :::.:. ::: XP_005 EIIEAFVQELRKRGSP 370 >>XP_016882689 (OMIM: 601703) PREDICTED: vasodilator-sti (378 aa) initn: 493 init1: 338 opt: 935 Z-score: 402.5 bits: 83.3 E(85289): 1.1e-15 Smith-Waterman score: 1085; 47.8% identity (67.4% similar) in 427 aa overlap (4-412:2-372) 10 20 30 40 50 pF1KE0 MATSEQSICQARASVMVYDDTSKKWVPIKPGQQGFSRINIYHNTASNTFRVVGVKLQ-DQ :: ::..::.::.::: .:.:.: : :.:::..:::: ..:.::::: :.: :: XP_016 MSETVICSSRATVMLYDDGNKRWLPAGTGPQAFSRVQIYHNPTANSFRVVGRKMQPDQ 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 QVVINYSIVKGLKYNQATPTFHQWRDARQVYGLNFASKEEATTFSNAMLFALNIMNSQEG ::::: .::.:.:::::::.::::::::::.::::.:::.:. :. .: ::. ... : XP_016 QVVINCAIVRGVKYNQATPNFHQWRDARQVWGLNFGSKEDAAQFAAGMASALEALEG--G 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 GPSSQR-----QVQNGPSPDEMDIQRRQVMEQHQQQRQESLERRTSATGPILPPGHPSSA :: .: :::::.:.. :.:: : .: .:::.: .: ::. :... XP_016 GPPPPPALPTWSVPNGPSPEEVEQQKRQ-----QPGPSEHIERRVSNAGG--PPAPPAGG 120 130 140 150 160 180 190 200 210 220 pF1KE0 ASAPVSCSGPPPPPPPPVPP--PPTGAT---------PPPPPPLPAGGAQGSSHDESSMS : :::::: :: :: ::.:. ::: ::::: ::: . .. XP_016 PPPP---PGPPPPPGPPPPPGLPPSGVPAAAHGAGGGPPPAPPLPA--AQGPGGGGAGAP 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE0 GLAAAIAGAKLRRVQRPEDASGGSSPSGTSKSDANRASSG-GGGGGLMEEMNKLLAKRRK ::::::::::::.:.. :.:::: :. : .: :: .:::::::::: .::.::: XP_016 GLAAAIAGAKLRKVSK-EEASGG--PT------APKAESGRSGGGGLMEEMNAMLARRRK 230 240 250 260 270 290 300 310 320 330 340 pF1KE0 AASQSDKPAEKKEDESQMEDPSTSPSPGTRAASQPPNSSEAGRKPWERSNSVEKPVSSIL :.. ..: . ::: :.: .. : .::. :.:::. ::. : . XP_016 ATQVGEKTPK---DESANEEPE----------ARVPAQSESVRRPWEK-NSTTLPR---M 280 290 300 310 350 360 370 380 390 400 pF1KE0 SRTPSVAKSPEAKSPLQSQPHSRMKPAGSVNDMALDAFDLDRMKQEILEEVVRELHKVKE . . ::. : ..:: . :..: : ::.:.:::.:::: .::.:::: XP_016 KSSSSVTTS-------ETQPCT---PSSS------DYSDLQRVKQELLEEVKKELQKVKE 320 330 340 350 360 410 pF1KE0 EIIDAIRQELSGISTT :::.:. ::: XP_016 EIIEAFVQELRKRGSP 370 >>XP_005273244 (OMIM: 609061) PREDICTED: protein enabled (605 aa) initn: 1277 init1: 472 opt: 697 Z-score: 304.6 bits: 65.9 E(85289): 3.1e-10 Smith-Waterman score: 757; 39.0% identity (52.9% similar) in 454 aa overlap (1-272:13-461) 10 20 30 40 pF1KE0 MATSEQSICQARASVMVYDDTSKKWVPIKPGQQGFSRINIYHNTASNT ...::::::::::.::::::..::::: :. ::::..:::.:..:: XP_005 MGRGSRIEACVLLGNSEQSICQARAAVMVYDDANKKWVPAG-GSTGFSRVHIYHHTGNNT 10 20 30 40 50 50 60 70 80 90 100 pF1KE0 FRVVGVKLQDQQVVINYSIVKGLKYNQATPTFHQWRDARQVYGLNFASKEEATTFSNAML ::::: :.::.::::: .: ::::::::: ::::::::::::::::.:::.:..:..::. XP_005 FRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMM 60 70 80 90 100 110 110 120 130 140 150 pF1KE0 FALNIMNSQEGGPSSQRQ-------VQNGPSPDEMDIQRRQVMEQHQQQ----------- ::...:::: ::. :: :::::: .:..:::::..::..:. XP_005 HALEVLNSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERER 120 130 140 150 160 170 pF1KE0 ----------------------------------RQESLERR------------------ ::: :::. XP_005 MERERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRE 180 190 200 210 220 230 160 pF1KE0 ----------------------------------------------------------TS .: XP_005 RQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSS 240 250 260 270 280 290 170 180 pF1KE0 AT---------------------GPI-------LPPGHPSSAASA-----------PVSC :. ::. :::: :..:. : :. XP_005 ASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPG-PAQASVALPPPPGPPPPPPLPS 300 310 320 330 340 350 190 200 210 220 230 pF1KE0 SGPPPPPPPP-----VPPPPTGATPPPPPPLPAGG--AQGSSHDESSMSGLAAAIAGAKL .::::::::: ::::: ::: :::::.: . :.:. ..::::::::::: XP_005 TGPPPPPPPPPLPNQVPPPP---PPPPAPPLPASGFFLASMSEDNRPLTGLAAAIAGAKL 360 370 380 390 400 410 240 250 260 270 280 pF1KE0 RRVQRPEDAS---GGSS---PSGTSKSDANRASSGG--GGGGLMEEMNKLLAKRRKAASQ :.:.: ::.: ::.. :..::.:..:... ::.::::: XP_005 RKVSRMEDTSFPSGGNAIGVNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRIAEK 420 430 440 450 460 470 290 300 310 320 330 340 pF1KE0 SDKPAEKKEDESQMEDPSTSPSPGTRAASQPPNSSEAGRKPWERSNSVEKPVSSILSRTP XP_005 GSTIETEQKEDKGEDSEPVTSKASSTSTPEPTRKPWERTNTMNGSKSPVISRRDSPRKNQ 480 490 500 510 520 530 418 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 04:35:43 2016 done: Sat Nov 5 04:35:45 2016 Total Scan time: 10.420 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]