FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0945, 350 aa 1>>>pF1KE0945 350 - 350 aa - 350 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4311+/-0.000371; mu= 16.0359+/- 0.023 mean_var=85.4180+/-18.224, 0's: 0 Z-trim(114.3): 114 B-trim: 684 in 1/51 Lambda= 0.138771 statistics sampled from 23891 (24045) to 23891 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.66), E-opt: 0.2 (0.282), width: 16 Scan time: 8.230 The best scores are: opt bits E(85289) NP_115613 (OMIM: 615247,615249,616094) protein O-m ( 350) 2388 488.1 1.2e-137 NP_001264900 (OMIM: 615247,615249,616094) protein ( 350) 2388 488.1 1.2e-137 XP_011512050 (OMIM: 600058) PREDICTED: tyrosine-pr ( 289) 195 49.0 1.6e-05 NP_001129473 (OMIM: 164690) Abelson tyrosine-prote ( 542) 194 49.0 2.9e-05 NP_001161711 (OMIM: 164690) Abelson tyrosine-prote (1043) 194 49.2 4.8e-05 NP_001161710 (OMIM: 164690) Abelson tyrosine-prote (1058) 194 49.2 4.8e-05 NP_001129472 (OMIM: 164690) Abelson tyrosine-prote (1064) 194 49.2 4.9e-05 NP_001161709 (OMIM: 164690) Abelson tyrosine-prote (1079) 194 49.2 4.9e-05 XP_005245145 (OMIM: 164690) PREDICTED: Abelson tyr (1146) 194 49.2 5.1e-05 NP_001161708 (OMIM: 164690) Abelson tyrosine-prote (1161) 194 49.2 5.2e-05 NP_005149 (OMIM: 164690) Abelson tyrosine-protein (1167) 194 49.2 5.2e-05 NP_009298 (OMIM: 164690) Abelson tyrosine-protein (1182) 194 49.3 5.3e-05 XP_016856524 (OMIM: 164690) PREDICTED: Abelson tyr (1182) 194 49.3 5.3e-05 NP_005148 (OMIM: 189980) tyrosine-protein kinase A (1130) 182 46.8 0.00027 NP_009297 (OMIM: 189980) tyrosine-protein kinase A (1149) 182 46.8 0.00027 XP_011533958 (OMIM: 606573) PREDICTED: tyrosine-pr ( 392) 160 42.1 0.0026 XP_005266937 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 160 42.1 0.0031 XP_016866134 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 160 42.1 0.0031 XP_005266938 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 160 42.1 0.0031 XP_005266939 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 160 42.1 0.0031 XP_011533957 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 160 42.1 0.0031 NP_002022 (OMIM: 606573) tyrosine-protein kinase F ( 505) 160 42.1 0.0031 XP_011533956 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 160 42.1 0.0031 XP_011533955 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 160 42.1 0.0031 XP_016866142 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537) 160 42.2 0.0032 XP_016866141 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537) 160 42.2 0.0032 XP_016866140 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537) 160 42.2 0.0032 NP_002028 (OMIM: 137025) tyrosine-protein kinase F ( 537) 160 42.2 0.0032 XP_016866143 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537) 160 42.2 0.0032 XP_016866139 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537) 160 42.2 0.0032 NP_694592 (OMIM: 137025) tyrosine-protein kinase F ( 534) 152 40.6 0.0098 XP_005266947 (OMIM: 137025) PREDICTED: tyrosine-pr ( 534) 152 40.6 0.0098 >>NP_115613 (OMIM: 615247,615249,616094) protein O-manno (350 aa) initn: 2388 init1: 2388 opt: 2388 Z-score: 2591.9 bits: 488.1 E(85289): 1.2e-137 Smith-Waterman score: 2388; 100.0% identity (100.0% similar) in 350 aa overlap (1-350:1-350) 10 20 30 40 50 60 pF1KE0 MEKQPQNSRRGLAPREVPPAVGLLLIMALMNTLLYLCLDHFFIAPRQSTVDPTHCPYGHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 MEKQPQNSRRGLAPREVPPAVGLLLIMALMNTLLYLCLDHFFIAPRQSTVDPTHCPYGHF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 RIGQMKNCSPWLSCEELRTEVRQLKRVGEGAVKRVFLSEWKEHKVALSQLTSLEMKDDFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 RIGQMKNCSPWLSCEELRTEVRQLKRVGEGAVKRVFLSEWKEHKVALSQLTSLEMKDDFL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 HGLQMLKSLQGTHVVTLLGYCEDDNTMLTEYHPLGSLSNLEETLNLSKYQNVNTWQHRLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 HGLQMLKSLQGTHVVTLLGYCEDDNTMLTEYHPLGSLSNLEETLNLSKYQNVNTWQHRLE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 LAMDYVSIINYLHHSPVGTRVMCDSNDLPKTLSQYLLTSNFSILANDLDALPLVNHSSGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 LAMDYVSIINYLHHSPVGTRVMCDSNDLPKTLSQYLLTSNFSILANDLDALPLVNHSSGM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 LVKCGHRELHGDFVAPEQLWPYGEDVPFHDDLMPSYDEKIDIWKIPDISSFLLGHIEGSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 LVKCGHRELHGDFVAPEQLWPYGEDVPFHDDLMPSYDEKIDIWKIPDISSFLLGHIEGSD 250 260 270 280 290 300 310 320 330 340 350 pF1KE0 MVRFHLFDIHKACKSQTPSERPTAQDVLETYQKVLDTLRDAMMSQAREML :::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 MVRFHLFDIHKACKSQTPSERPTAQDVLETYQKVLDTLRDAMMSQAREML 310 320 330 340 350 >>NP_001264900 (OMIM: 615247,615249,616094) protein O-ma (350 aa) initn: 2388 init1: 2388 opt: 2388 Z-score: 2591.9 bits: 488.1 E(85289): 1.2e-137 Smith-Waterman score: 2388; 100.0% identity (100.0% similar) in 350 aa overlap (1-350:1-350) 10 20 30 40 50 60 pF1KE0 MEKQPQNSRRGLAPREVPPAVGLLLIMALMNTLLYLCLDHFFIAPRQSTVDPTHCPYGHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEKQPQNSRRGLAPREVPPAVGLLLIMALMNTLLYLCLDHFFIAPRQSTVDPTHCPYGHF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 RIGQMKNCSPWLSCEELRTEVRQLKRVGEGAVKRVFLSEWKEHKVALSQLTSLEMKDDFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RIGQMKNCSPWLSCEELRTEVRQLKRVGEGAVKRVFLSEWKEHKVALSQLTSLEMKDDFL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 HGLQMLKSLQGTHVVTLLGYCEDDNTMLTEYHPLGSLSNLEETLNLSKYQNVNTWQHRLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HGLQMLKSLQGTHVVTLLGYCEDDNTMLTEYHPLGSLSNLEETLNLSKYQNVNTWQHRLE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 LAMDYVSIINYLHHSPVGTRVMCDSNDLPKTLSQYLLTSNFSILANDLDALPLVNHSSGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAMDYVSIINYLHHSPVGTRVMCDSNDLPKTLSQYLLTSNFSILANDLDALPLVNHSSGM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 LVKCGHRELHGDFVAPEQLWPYGEDVPFHDDLMPSYDEKIDIWKIPDISSFLLGHIEGSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVKCGHRELHGDFVAPEQLWPYGEDVPFHDDLMPSYDEKIDIWKIPDISSFLLGHIEGSD 250 260 270 280 290 300 310 320 330 340 350 pF1KE0 MVRFHLFDIHKACKSQTPSERPTAQDVLETYQKVLDTLRDAMMSQAREML :::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MVRFHLFDIHKACKSQTPSERPTAQDVLETYQKVLDTLRDAMMSQAREML 310 320 330 340 350 >>XP_011512050 (OMIM: 600058) PREDICTED: tyrosine-protei (289 aa) initn: 53 init1: 34 opt: 195 Z-score: 220.2 bits: 49.0 E(85289): 1.6e-05 Smith-Waterman score: 195; 22.7% identity (53.2% similar) in 299 aa overlap (60-337:6-288) 30 40 50 60 70 80 pF1KE0 MNTLLYLCLDHFFIAPRQSTVDPTHCPYGHFRIGQMKNCSPW---LSCEELR---TEVRQ . .: : .: : .: :. . .:. XP_011 MTRLRYPVGLMGSCLPATAGFSYEKWEIDPSELAF 10 20 30 90 100 110 120 130 140 pF1KE0 LKRVGEGAVKRVFLSEWKEH-KVALSQLTSLEM-KDDFLHGLQMLKSLQGTHVVTLLGYC .:..: : : :.::. : .::.. .. : ..::.. ... .:. ...: : : : XP_011 IKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVC 40 50 60 70 80 90 150 160 170 180 190 pF1KE0 EDDNTM--LTEYHPLGSLSNL--EETLNLSKYQNVNTWQHRLELAMDYVSIINYLHHSPV . . . .::. : : : :. .: : . ... : : .:.:. .:.:.. . XP_011 IQRKPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICE-GMEYLERNGYIHRDLA 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE0 GTRVMCDSNDLPKTLSQYLLTSNFSILANDLDALPLVNHSSGMLVKCGHRE--LHGDFVA . . .:. . : :.:.. :: . . .. . .: . : : . . . XP_011 ARNCLVSSTCIVKI-------SDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSS 160 170 180 190 200 260 270 280 290 300 pF1KE0 PEQLWPYGEDV--PFHDDLMPSYDEKIDIWKIPDISSFLLGHIEGSDMVRFHL-----FD ..: .: . : . :: ...: .. . :: :: . : :: .. XP_011 KSDVWSFGVLMWEVFTEGKMP-FENKSNLQVVEAIS-------EGFRLYRPHLAPMSIYE 210 220 230 240 250 310 320 330 340 350 pF1KE0 IHKACKSQTPSERPTAQDVLETYQKVLDTLRDAMMSQAREML . .: . : ::: ..:.. .. .: XP_011 VMYSCWHEKPEGRPTFAELLRAVTEIAETW 260 270 280 >>NP_001129473 (OMIM: 164690) Abelson tyrosine-protein k (542 aa) initn: 70 init1: 48 opt: 194 Z-score: 215.4 bits: 49.0 E(85289): 2.9e-05 Smith-Waterman score: 196; 21.3% identity (50.5% similar) in 329 aa overlap (31-345:218-529) 10 20 30 40 50 60 pF1KE0 MEKQPQNSRRGLAPREVPPAVGLLLIMALMNTLLYLCLDHFFIAPRQSTVDPTHCPYGHF .:: : : .: .. : : : . NP_001 ISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVA--DGLVTTLHYPAPKC 190 200 210 220 230 240 70 80 90 100 110 pF1KE0 RIGQMKNCSPWLSCEEL-RTEVRQLKRVGEGAVKRVFLSEWKEHK--VALSQLTSLEMK- . . :: . :. ::.. . ...: : .:... ::... ::.. : :. NP_001 NKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEV 250 260 270 280 290 300 120 130 140 150 160 170 pF1KE0 DDFLHGLQMLKSLQGTHVVTLLGYC--EDDNTMLTEYHPLGSLSNLEETLNLSKYQNVNT ..::. ..: .. ..: ::: : : ..::: : :.: . . : . : NP_001 EEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVL 310 320 330 340 350 360 180 190 200 210 220 pF1KE0 WQHRLEL--AMDYVSIINYLHHSPVGTRVMCDSNDLPKT----LSQYLLTSNFSILANDL .. ::.:. :..:.. .. . : . :. ::. . .... :. NP_001 LYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAG-- 370 380 390 400 410 420 230 240 250 260 270 280 pF1KE0 DALPLVNHSSGMLVKCGHRELHGDFVAPEQLWPYGEDVPFHDDLMPSYDEKIDIWKIPDI .:. . :. .. : ..: .: . : ::. .. :. NP_001 AKFPIKWTAPESLA-------YNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDL 430 440 450 460 470 290 300 310 320 330 340 pF1KE0 --SSFLLGHIEGSDMVRFHLFDIHKACKSQTPSERPTAQDVLETYQKVLDTLRDAMMSQA ... . . :: ..... .:: . .:..::. ::.: ..:. .:. NP_001 LEKGYRMEQPEGCPP---KVYELMRACWKWSPADRPS---FAETHQAFETMFHDSSISEV 480 490 500 510 520 530 350 pF1KE0 REML NP_001 LLHCANQTCITL 540 >>NP_001161711 (OMIM: 164690) Abelson tyrosine-protein k (1043 aa) initn: 48 init1: 48 opt: 194 Z-score: 211.6 bits: 49.2 E(85289): 4.8e-05 Smith-Waterman score: 196; 21.3% identity (50.5% similar) in 329 aa overlap (31-345:203-514) 10 20 30 40 50 60 pF1KE0 MEKQPQNSRRGLAPREVPPAVGLLLIMALMNTLLYLCLDHFFIAPRQSTVDPTHCPYGHF .:: : : .: .. : : : . NP_001 ISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVA--DGLVTTLHYPAPKC 180 190 200 210 220 230 70 80 90 100 110 pF1KE0 RIGQMKNCSPWLSCEEL-RTEVRQLKRVGEGAVKRVFLSEWKEHK--VALSQLTSLEMK- . . :: . :. ::.. . ...: : .:... ::... ::.. : :. NP_001 NKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEV 240 250 260 270 280 290 120 130 140 150 160 170 pF1KE0 DDFLHGLQMLKSLQGTHVVTLLGYC--EDDNTMLTEYHPLGSLSNLEETLNLSKYQNVNT ..::. ..: .. ..: ::: : : ..::: : :.: . . : . : NP_001 EEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVL 300 310 320 330 340 350 180 190 200 210 220 pF1KE0 WQHRLEL--AMDYVSIINYLHHSPVGTRVMCDSNDLPKT----LSQYLLTSNFSILANDL .. ::.:. :..:.. .. . : . :. ::. . .... :. NP_001 LYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAG-- 360 370 380 390 400 230 240 250 260 270 280 pF1KE0 DALPLVNHSSGMLVKCGHRELHGDFVAPEQLWPYGEDVPFHDDLMPSYDEKIDIWKIPDI .:. . :. .. : ..: .: . : ::. .. :. NP_001 AKFPIKWTAPESLA-------YNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDL 410 420 430 440 450 460 290 300 310 320 330 340 pF1KE0 --SSFLLGHIEGSDMVRFHLFDIHKACKSQTPSERPTAQDVLETYQKVLDTLRDAMMSQA ... . . :: ..... .:: . .:..::. ::.: ..:. .:. NP_001 LEKGYRMEQPEGCPP---KVYELMRACWKWSPADRPS---FAETHQAFETMFHDSSISEE 470 480 490 500 510 350 pF1KE0 REML NP_001 VAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFI 520 530 540 550 560 570 >>NP_001161710 (OMIM: 164690) Abelson tyrosine-protein k (1058 aa) initn: 48 init1: 48 opt: 194 Z-score: 211.5 bits: 49.2 E(85289): 4.8e-05 Smith-Waterman score: 196; 21.3% identity (50.5% similar) in 329 aa overlap (31-345:218-529) 10 20 30 40 50 60 pF1KE0 MEKQPQNSRRGLAPREVPPAVGLLLIMALMNTLLYLCLDHFFIAPRQSTVDPTHCPYGHF .:: : : .: .. : : : . NP_001 ISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVA--DGLVTTLHYPAPKC 190 200 210 220 230 240 70 80 90 100 110 pF1KE0 RIGQMKNCSPWLSCEEL-RTEVRQLKRVGEGAVKRVFLSEWKEHK--VALSQLTSLEMK- . . :: . :. ::.. . ...: : .:... ::... ::.. : :. NP_001 NKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEV 250 260 270 280 290 300 120 130 140 150 160 170 pF1KE0 DDFLHGLQMLKSLQGTHVVTLLGYC--EDDNTMLTEYHPLGSLSNLEETLNLSKYQNVNT ..::. ..: .. ..: ::: : : ..::: : :.: . . : . : NP_001 EEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVL 310 320 330 340 350 360 180 190 200 210 220 pF1KE0 WQHRLEL--AMDYVSIINYLHHSPVGTRVMCDSNDLPKT----LSQYLLTSNFSILANDL .. ::.:. :..:.. .. . : . :. ::. . .... :. NP_001 LYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAG-- 370 380 390 400 410 420 230 240 250 260 270 280 pF1KE0 DALPLVNHSSGMLVKCGHRELHGDFVAPEQLWPYGEDVPFHDDLMPSYDEKIDIWKIPDI .:. . :. .. : ..: .: . : ::. .. :. NP_001 AKFPIKWTAPESLA-------YNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDL 430 440 450 460 470 290 300 310 320 330 340 pF1KE0 --SSFLLGHIEGSDMVRFHLFDIHKACKSQTPSERPTAQDVLETYQKVLDTLRDAMMSQA ... . . :: ..... .:: . .:..::. ::.: ..:. .:. NP_001 LEKGYRMEQPEGCPP---KVYELMRACWKWSPADRPS---FAETHQAFETMFHDSSISEE 480 490 500 510 520 530 350 pF1KE0 REML NP_001 VAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFI 540 550 560 570 580 590 >>NP_001129472 (OMIM: 164690) Abelson tyrosine-protein k (1064 aa) initn: 48 init1: 48 opt: 194 Z-score: 211.5 bits: 49.2 E(85289): 4.9e-05 Smith-Waterman score: 196; 21.3% identity (50.5% similar) in 329 aa overlap (31-345:224-535) 10 20 30 40 50 60 pF1KE0 MEKQPQNSRRGLAPREVPPAVGLLLIMALMNTLLYLCLDHFFIAPRQSTVDPTHCPYGHF .:: : : .: .. : : : . NP_001 ISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVA--DGLVTTLHYPAPKC 200 210 220 230 240 250 70 80 90 100 110 pF1KE0 RIGQMKNCSPWLSCEEL-RTEVRQLKRVGEGAVKRVFLSEWKEHK--VALSQLTSLEMK- . . :: . :. ::.. . ...: : .:... ::... ::.. : :. NP_001 NKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEV 260 270 280 290 300 310 120 130 140 150 160 170 pF1KE0 DDFLHGLQMLKSLQGTHVVTLLGYC--EDDNTMLTEYHPLGSLSNLEETLNLSKYQNVNT ..::. ..: .. ..: ::: : : ..::: : :.: . . : . : NP_001 EEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVL 320 330 340 350 360 370 180 190 200 210 220 pF1KE0 WQHRLEL--AMDYVSIINYLHHSPVGTRVMCDSNDLPKT----LSQYLLTSNFSILANDL .. ::.:. :..:.. .. . : . :. ::. . .... :. NP_001 LYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAG-- 380 390 400 410 420 230 240 250 260 270 280 pF1KE0 DALPLVNHSSGMLVKCGHRELHGDFVAPEQLWPYGEDVPFHDDLMPSYDEKIDIWKIPDI .:. . :. .. : ..: .: . : ::. .. :. NP_001 AKFPIKWTAPESLA-------YNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDL 430 440 450 460 470 480 290 300 310 320 330 340 pF1KE0 --SSFLLGHIEGSDMVRFHLFDIHKACKSQTPSERPTAQDVLETYQKVLDTLRDAMMSQA ... . . :: ..... .:: . .:..::. ::.: ..:. .:. NP_001 LEKGYRMEQPEGCPP---KVYELMRACWKWSPADRPS---FAETHQAFETMFHDSSISEE 490 500 510 520 530 350 pF1KE0 REML NP_001 VAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFI 540 550 560 570 580 590 >>NP_001161709 (OMIM: 164690) Abelson tyrosine-protein k (1079 aa) initn: 48 init1: 48 opt: 194 Z-score: 211.4 bits: 49.2 E(85289): 4.9e-05 Smith-Waterman score: 196; 21.3% identity (50.5% similar) in 329 aa overlap (31-345:239-550) 10 20 30 40 50 60 pF1KE0 MEKQPQNSRRGLAPREVPPAVGLLLIMALMNTLLYLCLDHFFIAPRQSTVDPTHCPYGHF .:: : : .: .. : : : . NP_001 ISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVA--DGLVTTLHYPAPKC 210 220 230 240 250 260 70 80 90 100 110 pF1KE0 RIGQMKNCSPWLSCEEL-RTEVRQLKRVGEGAVKRVFLSEWKEHK--VALSQLTSLEMK- . . :: . :. ::.. . ...: : .:... ::... ::.. : :. NP_001 NKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEV 270 280 290 300 310 320 120 130 140 150 160 170 pF1KE0 DDFLHGLQMLKSLQGTHVVTLLGYC--EDDNTMLTEYHPLGSLSNLEETLNLSKYQNVNT ..::. ..: .. ..: ::: : : ..::: : :.: . . : . : NP_001 EEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVL 330 340 350 360 370 380 180 190 200 210 220 pF1KE0 WQHRLEL--AMDYVSIINYLHHSPVGTRVMCDSNDLPKT----LSQYLLTSNFSILANDL .. ::.:. :..:.. .. . : . :. ::. . .... :. NP_001 LYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAG-- 390 400 410 420 430 440 230 240 250 260 270 280 pF1KE0 DALPLVNHSSGMLVKCGHRELHGDFVAPEQLWPYGEDVPFHDDLMPSYDEKIDIWKIPDI .:. . :. .. : ..: .: . : ::. .. :. NP_001 AKFPIKWTAPESLA-------YNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDL 450 460 470 480 490 290 300 310 320 330 340 pF1KE0 --SSFLLGHIEGSDMVRFHLFDIHKACKSQTPSERPTAQDVLETYQKVLDTLRDAMMSQA ... . . :: ..... .:: . .:..::. ::.: ..:. .:. NP_001 LEKGYRMEQPEGCPP---KVYELMRACWKWSPADRPS---FAETHQAFETMFHDSSISEE 500 510 520 530 540 550 350 pF1KE0 REML NP_001 VAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFI 560 570 580 590 600 610 >>XP_005245145 (OMIM: 164690) PREDICTED: Abelson tyrosin (1146 aa) initn: 48 init1: 48 opt: 194 Z-score: 211.0 bits: 49.2 E(85289): 5.1e-05 Smith-Waterman score: 196; 21.3% identity (50.5% similar) in 329 aa overlap (31-345:203-514) 10 20 30 40 50 60 pF1KE0 MEKQPQNSRRGLAPREVPPAVGLLLIMALMNTLLYLCLDHFFIAPRQSTVDPTHCPYGHF .:: : : .: .. : : : . XP_005 ISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVA--DGLVTTLHYPAPKC 180 190 200 210 220 230 70 80 90 100 110 pF1KE0 RIGQMKNCSPWLSCEEL-RTEVRQLKRVGEGAVKRVFLSEWKEHK--VALSQLTSLEMK- . . :: . :. ::.. . ...: : .:... ::... ::.. : :. XP_005 NKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEV 240 250 260 270 280 290 120 130 140 150 160 170 pF1KE0 DDFLHGLQMLKSLQGTHVVTLLGYC--EDDNTMLTEYHPLGSLSNLEETLNLSKYQNVNT ..::. ..: .. ..: ::: : : ..::: : :.: . . : . : XP_005 EEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVL 300 310 320 330 340 350 180 190 200 210 220 pF1KE0 WQHRLEL--AMDYVSIINYLHHSPVGTRVMCDSNDLPKT----LSQYLLTSNFSILANDL .. ::.:. :..:.. .. . : . :. ::. . .... :. XP_005 LYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAG-- 360 370 380 390 400 230 240 250 260 270 280 pF1KE0 DALPLVNHSSGMLVKCGHRELHGDFVAPEQLWPYGEDVPFHDDLMPSYDEKIDIWKIPDI .:. . :. .. : ..: .: . : ::. .. :. XP_005 AKFPIKWTAPESLA-------YNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDL 410 420 430 440 450 460 290 300 310 320 330 340 pF1KE0 --SSFLLGHIEGSDMVRFHLFDIHKACKSQTPSERPTAQDVLETYQKVLDTLRDAMMSQA ... . . :: ..... .:: . .:..::. ::.: ..:. .:. XP_005 LEKGYRMEQPEGCPP---KVYELMRACWKWSPADRPS---FAETHQAFETMFHDSSISEE 470 480 490 500 510 350 pF1KE0 REML XP_005 VAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFI 520 530 540 550 560 570 >>NP_001161708 (OMIM: 164690) Abelson tyrosine-protein k (1161 aa) initn: 48 init1: 48 opt: 194 Z-score: 211.0 bits: 49.2 E(85289): 5.2e-05 Smith-Waterman score: 196; 21.3% identity (50.5% similar) in 329 aa overlap (31-345:218-529) 10 20 30 40 50 60 pF1KE0 MEKQPQNSRRGLAPREVPPAVGLLLIMALMNTLLYLCLDHFFIAPRQSTVDPTHCPYGHF .:: : : .: .. : : : . NP_001 ISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVA--DGLVTTLHYPAPKC 190 200 210 220 230 240 70 80 90 100 110 pF1KE0 RIGQMKNCSPWLSCEEL-RTEVRQLKRVGEGAVKRVFLSEWKEHK--VALSQLTSLEMK- . . :: . :. ::.. . ...: : .:... ::... ::.. : :. NP_001 NKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEV 250 260 270 280 290 300 120 130 140 150 160 170 pF1KE0 DDFLHGLQMLKSLQGTHVVTLLGYC--EDDNTMLTEYHPLGSLSNLEETLNLSKYQNVNT ..::. ..: .. ..: ::: : : ..::: : :.: . . : . : NP_001 EEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVL 310 320 330 340 350 360 180 190 200 210 220 pF1KE0 WQHRLEL--AMDYVSIINYLHHSPVGTRVMCDSNDLPKT----LSQYLLTSNFSILANDL .. ::.:. :..:.. .. . : . :. ::. . .... :. NP_001 LYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAG-- 370 380 390 400 410 420 230 240 250 260 270 280 pF1KE0 DALPLVNHSSGMLVKCGHRELHGDFVAPEQLWPYGEDVPFHDDLMPSYDEKIDIWKIPDI .:. . :. .. : ..: .: . : ::. .. :. NP_001 AKFPIKWTAPESLA-------YNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDL 430 440 450 460 470 290 300 310 320 330 340 pF1KE0 --SSFLLGHIEGSDMVRFHLFDIHKACKSQTPSERPTAQDVLETYQKVLDTLRDAMMSQA ... . . :: ..... .:: . .:..::. ::.: ..:. .:. NP_001 LEKGYRMEQPEGCPP---KVYELMRACWKWSPADRPS---FAETHQAFETMFHDSSISEE 480 490 500 510 520 530 350 pF1KE0 REML NP_001 VAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFI 540 550 560 570 580 590 350 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 04:39:23 2016 done: Sat Nov 5 04:39:24 2016 Total Scan time: 8.230 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]