FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0946, 367 aa 1>>>pF1KE0946 367 - 367 aa - 367 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.9302+/-0.00115; mu= 0.3505+/- 0.068 mean_var=269.0154+/-59.328, 0's: 0 Z-trim(111.7): 625 B-trim: 307 in 1/53 Lambda= 0.078196 statistics sampled from 11842 (12590) to 11842 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.741), E-opt: 0.2 (0.387), width: 16 Scan time: 3.000 The best scores are: opt bits E(32554) CCDS4112.1 TSSK1B gene_id:83942|Hs108|chr5 ( 367) 2475 292.5 4e-79 CCDS13755.1 TSSK2 gene_id:23617|Hs108|chr22 ( 358) 1597 193.4 2.6e-49 CCDS362.1 TSSK3 gene_id:81629|Hs108|chr1 ( 268) 866 110.8 1.4e-24 CCDS12403.1 TSSK6 gene_id:83983|Hs108|chr19 ( 273) 817 105.3 6.6e-23 CCDS60974.1 SIK3 gene_id:23387|Hs108|chr11 (1261) 702 93.0 1.5e-18 CCDS82645.1 LOC102724428 gene_id:102724428|Hs108|c ( 783) 696 92.1 1.8e-18 CCDS33575.1 SIK1 gene_id:150094|Hs108|chr21 ( 783) 696 92.1 1.8e-18 CCDS8379.2 SIK3 gene_id:23387|Hs108|chr11 (1321) 682 90.7 7.6e-18 CCDS8347.1 SIK2 gene_id:23235|Hs108|chr11 ( 926) 662 88.3 2.8e-17 CCDS73034.1 MARK1 gene_id:4139|Hs108|chr1 ( 780) 648 86.7 7.5e-17 CCDS31029.2 MARK1 gene_id:4139|Hs108|chr1 ( 795) 648 86.7 7.6e-17 CCDS73033.1 MARK1 gene_id:4139|Hs108|chr1 ( 796) 648 86.7 7.6e-17 CCDS53651.1 MARK2 gene_id:2011|Hs108|chr11 ( 709) 645 86.3 8.9e-17 CCDS55947.1 MARK3 gene_id:4140|Hs108|chr14 ( 713) 645 86.3 8.9e-17 CCDS53650.1 MARK2 gene_id:2011|Hs108|chr11 ( 719) 645 86.3 8.9e-17 CCDS8051.2 MARK2 gene_id:2011|Hs108|chr11 ( 724) 645 86.3 9e-17 CCDS41993.1 MARK3 gene_id:4140|Hs108|chr14 ( 729) 645 86.3 9e-17 CCDS45166.1 MARK3 gene_id:4140|Hs108|chr14 ( 744) 645 86.3 9.2e-17 CCDS41665.1 MARK2 gene_id:2011|Hs108|chr11 ( 745) 645 86.3 9.2e-17 CCDS45165.1 MARK3 gene_id:4140|Hs108|chr14 ( 753) 645 86.3 9.2e-17 CCDS53649.1 MARK2 gene_id:2011|Hs108|chr11 ( 788) 645 86.4 9.5e-17 CCDS12658.1 MARK4 gene_id:57787|Hs108|chr19 ( 688) 631 84.7 2.6e-16 CCDS56097.1 MARK4 gene_id:57787|Hs108|chr19 ( 752) 631 84.8 2.8e-16 CCDS43075.1 SNRK gene_id:54861|Hs108|chr3 ( 765) 608 82.2 1.7e-15 CCDS31892.1 NUAK1 gene_id:9891|Hs108|chr12 ( 661) 604 81.6 2.1e-15 CCDS1453.2 NUAK2 gene_id:81788|Hs108|chr1 ( 672) 592 80.3 5.4e-15 CCDS3932.2 PRKAA1 gene_id:5562|Hs108|chr5 ( 559) 579 78.8 1.3e-14 CCDS605.1 PRKAA2 gene_id:5563|Hs108|chr1 ( 552) 574 78.2 1.9e-14 CCDS13610.1 HUNK gene_id:30811|Hs108|chr21 ( 714) 575 78.4 2.1e-14 CCDS41590.1 BRSK2 gene_id:9024|Hs108|chr11 ( 668) 565 77.3 4.4e-14 CCDS58106.1 BRSK2 gene_id:9024|Hs108|chr11 ( 674) 565 77.3 4.5e-14 CCDS58107.1 BRSK2 gene_id:9024|Hs108|chr11 ( 736) 565 77.3 4.7e-14 CCDS12921.1 BRSK1 gene_id:84446|Hs108|chr19 ( 778) 556 76.3 1e-13 CCDS3943.1 NIM1K gene_id:167359|Hs108|chr5 ( 436) 549 75.3 1.1e-13 CCDS58108.1 BRSK2 gene_id:9024|Hs108|chr11 ( 766) 552 75.8 1.3e-13 CCDS59123.1 MELK gene_id:9833|Hs108|chr9 ( 610) 543 74.7 2.3e-13 CCDS6606.1 MELK gene_id:9833|Hs108|chr9 ( 651) 543 74.8 2.4e-13 CCDS2582.1 CAMK1 gene_id:8536|Hs108|chr3 ( 370) 532 73.3 3.9e-13 CCDS60696.1 BRSK2 gene_id:9024|Hs108|chr11 ( 614) 514 71.5 2.3e-12 CCDS1486.1 CAMK1G gene_id:57172|Hs108|chr1 ( 476) 491 68.8 1.1e-11 CCDS13843.1 CHEK2 gene_id:11200|Hs108|chr22 ( 543) 491 68.8 1.2e-11 CCDS33629.1 CHEK2 gene_id:11200|Hs108|chr22 ( 586) 491 68.8 1.3e-11 CCDS59126.1 MELK gene_id:9833|Hs108|chr9 ( 619) 490 68.8 1.5e-11 CCDS65789.1 MARK1 gene_id:4139|Hs108|chr1 ( 758) 475 67.2 5.5e-11 CCDS73254.1 STK33 gene_id:65975|Hs108|chr11 ( 473) 468 66.2 6.9e-11 CCDS7092.1 CAMK1D gene_id:57118|Hs108|chr10 ( 357) 465 65.7 7.1e-11 CCDS7789.1 STK33 gene_id:65975|Hs108|chr11 ( 514) 468 66.2 7.3e-11 CCDS7091.1 CAMK1D gene_id:57118|Hs108|chr10 ( 385) 465 65.7 7.5e-11 CCDS10616.1 PLK1 gene_id:5347|Hs108|chr16 ( 603) 467 66.2 8.8e-11 >>CCDS4112.1 TSSK1B gene_id:83942|Hs108|chr5 (367 aa) initn: 2475 init1: 2475 opt: 2475 Z-score: 1534.0 bits: 292.5 E(32554): 4e-79 Smith-Waterman score: 2475; 100.0% identity (100.0% similar) in 367 aa overlap (1-367:1-367) 10 20 30 40 50 60 pF1KE0 MDDAAVLKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 MDDAAVLKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPRE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 IEILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 IEILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 SLAIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 SLAIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 YAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 YAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 LTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQPKARGSPSVAINKEGESSRGTEPLWTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 LTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQPKARGSPSVAINKEGESSRGTEPLWTP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 EPGSDKKSATKLEPEGEAQPQAQPETKPEGTAMQMSRQSEILGFPSKPSTMETEEGPPQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 EPGSDKKSATKLEPEGEAQPQAQPETKPEGTAMQMSRQSEILGFPSKPSTMETEEGPPQQ 310 320 330 340 350 360 pF1KE0 PPETRAQ ::::::: CCDS41 PPETRAQ >>CCDS13755.1 TSSK2 gene_id:23617|Hs108|chr22 (358 aa) initn: 1602 init1: 1566 opt: 1597 Z-score: 998.9 bits: 193.4 E(32554): 2.6e-49 Smith-Waterman score: 1597; 71.8% identity (89.4% similar) in 330 aa overlap (1-327:1-330) 10 20 30 40 50 60 pF1KE0 MDDAAVLKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPRE ::::.::...::..:::::.:::::::::::::::::::.:::::::.:.::.:.::::: CCDS13 MDDATVLRKKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPRE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 IEILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQL ..::: .:: :::::::::::: :..::.:::.:::::::.:: .:::::: ::: :.:: CCDS13 MDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 SLAIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPA : :.:::::::.:::::::.:::::::::::::::.::::::::..::. :::::::: : CCDS13 SSAVKYCHDLDIVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 YAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKH ::::::::.::::::::::::::::::::::::::::::.:.:::::::::::.:::::. CCDS13 YAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRSKN 190 200 210 220 230 240 250 260 270 280 290 pF1KE0 LTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQP-KARGSPSVAINKEGESSRGTEPLWT :: :::::::.::::::..:::::::::: :.:: : ... :.....:::.. .: CCDS13 LTCECKDLIYRMLQPDVSQRLHIDEILSHSWLQPPKPKATSSASFKREGEGKYRAECKLD 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE0 PEPG--SDKKSATKLEPEGEAQPQAQPETKPEGTAMQMSRQSEILGFPSKPSTMETEEGP . : :.. :: . . . . ::.. CCDS13 TKTGLRPDHRPDHKLGAKTQHRLLVVPENENRMEDRLAETSRAKDHHISGAEVGKAST 310 320 330 340 350 >>CCDS362.1 TSSK3 gene_id:81629|Hs108|chr1 (268 aa) initn: 825 init1: 447 opt: 866 Z-score: 554.7 bits: 110.8 E(32554): 1.4e-24 Smith-Waterman score: 866; 47.4% identity (76.5% similar) in 272 aa overlap (1-272:1-265) 10 20 30 40 50 60 pF1KE0 MDDAAVLKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPRE :.: : :: :: ..:::.:.::: :.:.. . .::::.::. .: .:...::::: CCDS36 MED--FLLSNGYQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRE 10 20 30 40 50 70 80 90 100 110 120 pF1KE0 IEILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQL ..:. :.: .::..::..:.. ::. .::::: ::... . . : : :..:. :.:. CCDS36 LQIVRTLDHKNIIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQM 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE0 SLAIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPA ::.::: :.::::::.: :: . ::.::.::.:.: . : : ::.::::: : CCDS36 VEAIRYCHGCGVAHRDLKCENALL-QGFNLKLTDFGFAK--VLPKSHR-ELSQTFCGSTA 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE0 YAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKH :::::::::::.. : :.::.::.::.:.:.:.:.::..: ::: :... :.:: CCDS36 YAAPEVLQGIPHDSKKGDVWSMGVVLYVMLCASLPFDDTDIPKMLW-QQQKGVSFPTHLS 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE0 LTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQPKARGSPSVAINKEGESSRGTEPLWTP ....:.::. ..:.::. : :.:. : :. CCDS36 ISADCQDLLKRLLEPDMILRPSIEEVSWHPWLAST 240 250 260 310 320 330 340 350 360 pF1KE0 EPGSDKKSATKLEPEGEAQPQAQPETKPEGTAMQMSRQSEILGFPSKPSTMETEEGPPQQ >>CCDS12403.1 TSSK6 gene_id:83983|Hs108|chr19 (273 aa) initn: 771 init1: 302 opt: 817 Z-score: 524.8 bits: 105.3 E(32554): 6.6e-23 Smith-Waterman score: 817; 46.2% identity (72.0% similar) in 279 aa overlap (1-278:1-273) 10 20 30 40 50 60 pF1KE0 MDDAAVLKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPRE :. .:.. :: :: ..:::::.::: : :.. : .::::..::..:: ::..:::::: CCDS12 MSGDKLLSELGYKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 IEILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQL . :: . : :....:..:. .::.::::: :. :::. .. : . .:: : :. CCDS12 LSILRGVRHPHIVHVFEFIEVCNGKLYIVMEAAAT-DLLQAVQRNGRIPGVQARDLFAQI 70 80 90 100 110 130 140 150 160 170 pF1KE0 SLAIKYCHDLDVVHRDLKCDNLLLDKDFN-IKLSDFSFSKRCLRDDSGRMALSKTFCGSP . :..: :: .:::::::.:.::. : .::.::.:. :. : :: :.::: CCDS12 AGAVRYLHDHHLVHRDLKCENVLLSPDERRVKLTDFGFG----RQAHGYPDLSTTYCGSA 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 AYAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSK :::.:::: ::::.:: ::.::.::.::.:: : ::.:::.: . : ::. : .:.. CCDS12 AYASPEVLLGIPYDPKKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQKRG-VLYPEGL 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE0 HLTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQPKARGSPSVAINKEGESSRGTEPLWT .:. .:: :: ..:: . . : .. .::.. : CCDS12 ELSERCKALIAELLQFSPSARPSAGQVARNCWLRAGDSG 240 250 260 270 300 310 320 330 340 350 pF1KE0 PEPGSDKKSATKLEPEGEAQPQAQPETKPEGTAMQMSRQSEILGFPSKPSTMETEEGPPQ >>CCDS60974.1 SIK3 gene_id:23387|Hs108|chr11 (1261 aa) initn: 657 init1: 245 opt: 702 Z-score: 446.3 bits: 93.0 E(32554): 1.5e-18 Smith-Waterman score: 707; 38.2% identity (65.4% similar) in 356 aa overlap (9-340:62-404) 10 20 30 pF1KE0 MDDAAVLKRRGYL-LGINLGEGSYAKVKSAYSERLKFN : :: . ..:.:..: :: : : . CCDS60 PGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAK 40 50 60 70 80 90 40 50 60 70 80 90 pF1KE0 VAIKIIDRKKAPADFLEKFLPREIEILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGD :::::::. . . :.:.. ::..:. :: : ::. :...:: . .:.: : : :. CCDS60 VAIKIIDKTQLDEENLKKIF-REVQIMKMLCHPHIIRLYQVMETER-MIYLVTEYASGGE 100 110 120 130 140 100 110 120 130 140 150 pF1KE0 LLELIKTRGALHEDEARKKFHQLSLAIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSF ... . ..: . : :::.::.:. :. .:: ..:::::: .::::: ..:::..::.: CCDS60 IFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF 150 160 170 180 190 200 160 170 180 190 200 210 pF1KE0 SKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIPYQ-PKVYDIWSLGVILYIMVCGSMPY :. :. : ::.:::: :::::...: :. ::: :::::::.::..:::..:. CCDS60 SNLFT---PGQ--LLKTWCGSPPYAAPELFEGKEYDGPKV-DIWSLGVVLYVLVCGALPF 210 220 230 240 250 260 220 230 240 250 260 270 pF1KE0 DDSNIKKM-LRIQK-EHRVNFPRSKHLTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQP : :..... :. . . :. : .. ::. :: ::: : :.:: ...: .: ::. CCDS60 DGSTLQNLRARVLSGKFRIPF----FMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMK- 270 280 290 300 310 280 290 300 310 320 pF1KE0 KARGSPS----VAINKEGESSRGTEPL------WTPEPGSDKKSATKLEPEGEAQ----P . ..:. .: .. . : ..:: . : ::... . : : :. : CCDS60 LGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQAEQAGTAMNISVP 320 330 340 350 360 370 330 340 350 360 pF1KE0 QAQ---PETK---PEGTAMQMSRQSEILGFPSKPSTMETEEGPPQQPPETRAQ :.: ::.. :.:: : ..: CCDS60 QVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKL 380 390 400 410 420 430 >>CCDS82645.1 LOC102724428 gene_id:102724428|Hs108|chr21 (783 aa) initn: 730 init1: 263 opt: 696 Z-score: 445.3 bits: 92.1 E(32554): 1.8e-18 Smith-Waterman score: 696; 43.5% identity (68.8% similar) in 276 aa overlap (18-291:33-299) 10 20 30 40 pF1KE0 MDDAAVLKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKK ::.:..: :: : . : .:::::::. . CCDS82 IMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTR 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE0 APADFLEKFLPREIEILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGA .. :::. ::.... .::: ::: :...::. .::: :.: .:.... . . : CCDS82 LDSSNLEKIY-REVQLMKLLNHPHIIKLYQVMETKD-MLYIVTEFAKNGEMFDYLTSNGH 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE0 LHEDEARKKFHQLSLAIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSG : :.:::::: :. :..:::: .:::::: .::::: ...:::.::.:.. :: CCDS82 LSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGN---FYKSG 130 140 150 160 170 170 180 190 200 210 220 pF1KE0 RMALSKTFCGSPAYAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRI . :: :.:::: ::::::..: :. :::::::.::..::::.:.: :. . . CCDS82 E-PLS-TWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQR 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE0 QKEHRVNFPRSKHLTGECKDLIYHMLQPDVNRRLHIDEILSHCWM--QPKARGSPSVAIN : : .: .. .:..:: .:: : ::. : .: .: :: .: : :.. CCDS82 VLEGRFRIPF--FMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFS 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE0 KEGESSRGTEPLWTPEPGSDKKSATKLEPEGEAQPQAQPETKPEGTAMQMSRQSEILGFP .. .: CCDS82 AHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQC 300 310 320 330 340 350 >>CCDS33575.1 SIK1 gene_id:150094|Hs108|chr21 (783 aa) initn: 730 init1: 263 opt: 696 Z-score: 445.3 bits: 92.1 E(32554): 1.8e-18 Smith-Waterman score: 696; 43.5% identity (68.8% similar) in 276 aa overlap (18-291:33-299) 10 20 30 40 pF1KE0 MDDAAVLKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKK ::.:..: :: : . : .:::::::. . CCDS33 IMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTR 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE0 APADFLEKFLPREIEILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGA .. :::. ::.... .::: ::: :...::. .::: :.: .:.... . . : CCDS33 LDSSNLEKIY-REVQLMKLLNHPHIIKLYQVMETKD-MLYIVTEFAKNGEMFDYLTSNGH 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE0 LHEDEARKKFHQLSLAIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSG : :.:::::: :. :..:::: .:::::: .::::: ...:::.::.:.. :: CCDS33 LSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGN---FYKSG 130 140 150 160 170 170 180 190 200 210 220 pF1KE0 RMALSKTFCGSPAYAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRI . :: :.:::: ::::::..: :. :::::::.::..::::.:.: :. . . CCDS33 E-PLS-TWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQR 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE0 QKEHRVNFPRSKHLTGECKDLIYHMLQPDVNRRLHIDEILSHCWM--QPKARGSPSVAIN : : .: .. .:..:: .:: : ::. : .: .: :: .: : :.. CCDS33 VLEGRFRIPF--FMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFS 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE0 KEGESSRGTEPLWTPEPGSDKKSATKLEPEGEAQPQAQPETKPEGTAMQMSRQSEILGFP .. .: CCDS33 AHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQC 300 310 320 330 340 350 >>CCDS8379.2 SIK3 gene_id:23387|Hs108|chr11 (1321 aa) initn: 682 init1: 245 opt: 682 Z-score: 433.9 bits: 90.7 E(32554): 7.6e-18 Smith-Waterman score: 682; 42.8% identity (70.6% similar) in 269 aa overlap (9-273:62-318) 10 20 30 pF1KE0 MDDAAVLKRRGYL-LGINLGEGSYAKVKSAYSERLKFN : :: . ..:.:..: :: : : . CCDS83 PGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAK 40 50 60 70 80 90 40 50 60 70 80 90 pF1KE0 VAIKIIDRKKAPADFLEKFLPREIEILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGD :::::::. . . :.:.. ::..:. :: : ::. :...:: . .:.: : : :. CCDS83 VAIKIIDKTQLDEENLKKIF-REVQIMKMLCHPHIIRLYQVMETER-MIYLVTEYASGGE 100 110 120 130 140 100 110 120 130 140 150 pF1KE0 LLELIKTRGALHEDEARKKFHQLSLAIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSF ... . ..: . : :::.::.:. :. .:: ..:::::: .::::: ..:::..::.: CCDS83 IFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF 150 160 170 180 190 200 160 170 180 190 200 210 pF1KE0 SKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIPYQ-PKVYDIWSLGVILYIMVCGSMPY :. :. : ::.:::: :::::...: :. ::: :::::::.::..:::..:. CCDS83 SNLF---TPGQ--LLKTWCGSPPYAAPELFEGKEYDGPKV-DIWSLGVVLYVLVCGALPF 210 220 230 240 250 260 220 230 240 250 260 270 pF1KE0 DDSNIKKM-LRIQK-EHRVNFPRSKHLTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQP : :..... :. . . :. : .. ::. :: ::: : :.:: ...: .: ::. CCDS83 DGSTLQNLRARVLSGKFRIPF----FMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKL 270 280 290 300 310 280 290 300 310 320 330 pF1KE0 KARGSPSVAINKEGESSRGTEPLWTPEPGSDKKSATKLEPEGEAQPQAQPETKPEGTAMQ CCDS83 GDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIY 320 330 340 350 360 370 >>CCDS8347.1 SIK2 gene_id:23235|Hs108|chr11 (926 aa) initn: 762 init1: 247 opt: 662 Z-score: 423.6 bits: 88.3 E(32554): 2.8e-17 Smith-Waterman score: 662; 43.1% identity (70.2% similar) in 255 aa overlap (18-272:26-271) 10 20 30 40 50 pF1KE0 MDDAAVLKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADF ::.:..: :: . . : .:::::::... : CCDS83 MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 LEKFLPREIEILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDE ::: . ::..:. ::.: ::: :...::. . .:.: : : .:.... . ..: :.:.: CCDS83 LEK-IYREVQIMKMLDHPHIIKLYQVMETK-SMLYLVTEYAKNGEIFDYLANHGRLNESE 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 ARKKFHQLSLAIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALS ::.:: :. :. ::: .:::::: .:::::...:::..::.:.. ::. : CCDS83 ARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFF---KSGE--LL 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 KTFCGSPAYAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHR :.:::: ::::::..: :. ::::.::.::..:::..:.: .. . . : : CCDS83 ATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGR 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE0 VNFPRSKHLTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQPKARGSPSVAINKEGESSR .: .. .:. :: .:: : ..:: : .: : :: CCDS83 FRIPY--FMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEP 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE0 GTEPLWTPEPGSDKKSATKLEPEGEAQPQAQPETKPEGTAMQMSRQSEILGFPSKPSTME CCDS83 SIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLD 300 310 320 330 340 350 >>CCDS73034.1 MARK1 gene_id:4139|Hs108|chr1 (780 aa) initn: 606 init1: 258 opt: 648 Z-score: 416.0 bits: 86.7 E(32554): 7.5e-17 Smith-Waterman score: 648; 39.9% identity (70.3% similar) in 263 aa overlap (12-272:60-311) 10 20 30 40 pF1KE0 MDDAAVLKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIK : : ..:.:..:::: : .::.: CCDS73 QPTKSSSRQNIPRCRNSITSATDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVK 30 40 50 60 70 80 50 60 70 80 90 100 pF1KE0 IIDRKKAPADFLEKFLPREIEILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLEL :::. . :.:.. ::..:. .::: .:.: .:..:: . .:.::: : :.... CCDS73 IIDKTQLNPTSLQKLF-REVRIMKILNHPNIVKLFEVIETEK-TLYLVMEYASGGEVFDY 90 100 110 120 130 140 110 120 130 140 150 160 pF1KE0 IKTRGALHEDEARKKFHQLSLAIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRC . ..: ..: ::: ::.:. :..:::. .:::::: .::::: :.:::..::.::.. CCDS73 LVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEF 150 160 170 180 190 200 170 180 190 200 210 220 pF1KE0 LRDDSGRMALSKTFCGSPAYAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNI .. :::::: :::::..:: :. :.:::::::: .: ::.:.: .:. CCDS73 TVGNK-----LDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNL 210 220 230 240 250 260 230 240 250 260 270 pF1KE0 KKML-RIQK-EHRVNFPRSKHLTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQPKARGS :.. :. . ..:. : ... .:..:. ..: . .: ...:.. :: CCDS73 KELRERVLRGKYRIPF----YMSTDCENLLKKLLVLNPIKRGSLEQIMKDRWMNVGHEEE 270 280 290 300 310 280 290 300 310 320 330 pF1KE0 PSVAINKEGESSRGTEPLWTPEPGSDKKSATKLEPEGEAQPQAQPETKPEGTAMQMSRQS CCDS73 ELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYDEVMATYILLGRKPPEFEGG 320 330 340 350 360 370 367 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 04:39:53 2016 done: Sat Nov 5 04:39:53 2016 Total Scan time: 3.000 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]