FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0947, 385 aa 1>>>pF1KE0947 385 - 385 aa - 385 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.1232+/-0.000571; mu= -0.7985+/- 0.034 mean_var=607.9323+/-135.181, 0's: 0 Z-trim(117.4): 1634 B-trim: 0 in 0/52 Lambda= 0.052017 statistics sampled from 27063 (29419) to 27063 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.686), E-opt: 0.2 (0.345), width: 16 Scan time: 8.760 The best scores are: opt bits E(85289) NP_006733 (OMIM: 177015) serine/threonine-protein ( 424) 1583 134.4 4.8e-31 XP_006717546 (OMIM: 607957) PREDICTED: calcium/cal ( 355) 852 79.4 1.5e-14 NP_065130 (OMIM: 607957) calcium/calmodulin-depend ( 357) 852 79.4 1.5e-14 XP_006717545 (OMIM: 607957) PREDICTED: calcium/cal ( 362) 852 79.4 1.5e-14 NP_705718 (OMIM: 607957) calcium/calmodulin-depend ( 385) 852 79.5 1.5e-14 NP_001034671 (OMIM: 300680) calcium/calmodulin-dep ( 426) 836 78.3 3.6e-14 XP_016884766 (OMIM: 300680) PREDICTED: calcium/cal ( 426) 836 78.3 3.6e-14 NP_003647 (OMIM: 604998) calcium/calmodulin-depend ( 370) 833 78.0 4e-14 XP_005265573 (OMIM: 604998) PREDICTED: calcium/cal ( 413) 833 78.1 4.2e-14 XP_006717544 (OMIM: 607957) PREDICTED: calcium/cal ( 366) 829 77.7 4.9e-14 XP_011517893 (OMIM: 607957) PREDICTED: calcium/cal ( 372) 829 77.7 4.9e-14 XP_005274708 (OMIM: 300680) PREDICTED: calcium/cal ( 343) 795 75.1 2.8e-13 XP_011529413 (OMIM: 300680) PREDICTED: calcium/cal ( 343) 795 75.1 2.8e-13 XP_011529412 (OMIM: 300680) PREDICTED: calcium/cal ( 343) 795 75.1 2.8e-13 XP_016884767 (OMIM: 300680) PREDICTED: calcium/cal ( 343) 795 75.1 2.8e-13 XP_011529414 (OMIM: 300680) PREDICTED: calcium/cal ( 343) 795 75.1 2.8e-13 XP_011529409 (OMIM: 300680) PREDICTED: calcium/cal ( 343) 795 75.1 2.8e-13 XP_016884768 (OMIM: 300680) PREDICTED: calcium/cal ( 343) 795 75.1 2.8e-13 XP_006724872 (OMIM: 300680) PREDICTED: calcium/cal ( 343) 795 75.1 2.8e-13 NP_001129212 (OMIM: 300680) calcium/calmodulin-dep ( 360) 795 75.1 2.8e-13 XP_011529410 (OMIM: 300680) PREDICTED: calcium/cal ( 361) 795 75.1 2.8e-13 XP_016857355 (OMIM: 614994) PREDICTED: calcium/cal ( 476) 776 73.9 8.7e-13 NP_065172 (OMIM: 614994) calcium/calmodulin-depend ( 476) 776 73.9 8.7e-13 NP_001310304 (OMIM: 114080) calcium/calmodulin-dep ( 473) 762 72.9 1.8e-12 NP_001310303 (OMIM: 114080) calcium/calmodulin-dep ( 473) 762 72.9 1.8e-12 NP_001735 (OMIM: 114080) calcium/calmodulin-depend ( 473) 762 72.9 1.8e-12 XP_011517895 (OMIM: 607957) PREDICTED: calcium/cal ( 311) 718 69.3 1.5e-11 XP_011517894 (OMIM: 607957) PREDICTED: calcium/cal ( 315) 718 69.3 1.5e-11 XP_016862843 (OMIM: 604998) PREDICTED: calcium/cal ( 326) 711 68.8 2.1e-11 XP_005265574 (OMIM: 604998) PREDICTED: calcium/cal ( 369) 711 68.9 2.3e-11 NP_001182345 (OMIM: 604742) serine/threonine-prote ( 433) 696 67.9 5.3e-11 XP_016863321 (OMIM: 613166) PREDICTED: serine/thre ( 717) 697 68.3 6.4e-11 NP_001317001 (OMIM: 604742) serine/threonine-prote ( 740) 696 68.3 6.9e-11 NP_001317000 (OMIM: 604742) serine/threonine-prote ( 740) 696 68.3 6.9e-11 NP_001035350 (OMIM: 613166) serine/threonine-prote ( 766) 696 68.3 7e-11 NP_001035351 (OMIM: 613166) serine/threonine-prote ( 783) 696 68.3 7.1e-11 NP_001182344 (OMIM: 604742) serine/threonine-prote ( 422) 690 67.4 7.2e-11 XP_005262843 (OMIM: 613166) PREDICTED: serine/thre ( 765) 695 68.2 7.4e-11 XP_005262842 (OMIM: 613166) PREDICTED: serine/thre ( 782) 695 68.2 7.5e-11 NP_001307076 (OMIM: 614993) caM kinase-like vesicl ( 470) 690 67.5 7.6e-11 NP_076951 (OMIM: 614993) caM kinase-like vesicle-a ( 501) 690 67.5 7.8e-11 NP_004725 (OMIM: 604742) serine/threonine-protein ( 729) 690 67.8 9.4e-11 XP_016876336 (OMIM: 604742) PREDICTED: serine/thre ( 708) 689 67.7 9.7e-11 XP_016871928 (OMIM: 607957) PREDICTED: calcium/cal ( 260) 656 64.5 3.4e-10 XP_016871927 (OMIM: 607957) PREDICTED: calcium/cal ( 288) 656 64.5 3.5e-10 XP_011517897 (OMIM: 607957) PREDICTED: calcium/cal ( 288) 656 64.5 3.5e-10 NP_001305866 (OMIM: 601685) ribosomal protein S6 k ( 635) 636 63.6 1.5e-09 NP_001305867 (OMIM: 601685) ribosomal protein S6 k ( 644) 636 63.6 1.5e-09 NP_208382 (OMIM: 613167) serine/threonine-protein ( 648) 636 63.7 1.5e-09 XP_011532469 (OMIM: 613167) PREDICTED: serine/thre ( 648) 636 63.7 1.5e-09 >>NP_006733 (OMIM: 177015) serine/threonine-protein kina (424 aa) initn: 1610 init1: 1556 opt: 1583 Z-score: 678.3 bits: 134.4 E(85289): 4.8e-31 Smith-Waterman score: 1583; 65.4% identity (84.6% similar) in 370 aa overlap (9-375:48-412) 10 20 30 pF1KE0 MGCGASRKVVPGPPALAWAKHEGQNQAGVGGAGPGPEA : : :: . : . .: . : : NP_006 LDLVKKVEPFSGTKSDVYKHFITEVDSVGPVKAGFPAASQYAHPCPGPPTAGHTEP-P-- 20 30 40 50 60 70 40 50 60 70 80 90 pF1KE0 AAQAAQRIQVARFRAKFDPRVLARYDIKALIGTGSFSRVVRVEQKTTKKPFAIKVMETRE .. .: .::..:::::::: :.:::::::: ::::::::::...:..:.:::..::. NP_006 -SEPPRRARVAKYRAKFDPRVTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKY 80 90 100 110 120 130 100 110 120 130 140 150 pF1KE0 REGREACVSELSVLRRVSHRYIVQLMEIFETEDQVYMVMELATGGELFDRLIAQGSFTER :::::.: ::: ::::: : :.::.:.:::...::::::::::::::::.::.:::::: NP_006 REGREVCESELRVLRRVRHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTER 140 150 160 170 180 190 160 170 180 190 200 210 pF1KE0 DAVRILQMVADGIRYLHALQITHRNLKPENLLYYHPGEESKILITDFGLAYSGKKSGDWT ::.:.:::: ::.:::::: ::::.:::::::::::: .:::.::::::: . ::. : NP_006 DATRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCL 200 210 220 230 240 250 220 230 240 250 260 270 pF1KE0 MKTLCGTPEYIAPEVLLRKPYTSAVDMWALGVITYALLSGFLPFDDESQTRLYRKILKGK ::: ::::::::::::.:::::..:::::::::.: :::: .::.:...:::::.::.:: NP_006 MKTTCGTPEYIAPEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGK 260 270 280 290 300 310 280 290 300 310 320 330 pF1KE0 YNYTGEPWPSISHLAKDFIDKLLILEAGHRMSAGQALDHPWVITMAAGSSMKNLQRAISR :.:.::::::.:.:::::::.:: .. : ::.: ::: ::::..:::.::::::.:.::. NP_006 YSYSGEPWPSVSNLAKDFIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQ 320 330 340 350 360 370 340 350 360 370 380 pF1KE0 NLMQRASPHSQSPGSAQS---SKSHYSHKSRHMWSKRNLRIVESPLSALL ::..::: . :: :::: :.: :.:::.. .:.:: NP_006 NLLKRASSRCQSTKSAQSTRSSRSTRSNKSRRV-RERELRELNLRYQQQYNG 380 390 400 410 420 >>XP_006717546 (OMIM: 607957) PREDICTED: calcium/calmodu (355 aa) initn: 828 init1: 378 opt: 852 Z-score: 382.4 bits: 79.4 E(85289): 1.5e-14 Smith-Waterman score: 852; 46.2% identity (78.1% similar) in 279 aa overlap (63-337:23-294) 40 50 60 70 80 90 pF1KE0 GPGPEAAAQAAQRIQVARFRAKFDPRVLARYDIKALIGTGSFSRVVRVEQKTTKKPFAIK ...: .:::.::.:: .:.:.: : ::.: XP_006 MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVK 10 20 30 40 50 100 110 120 130 140 150 pF1KE0 VMETREREGREACV-SELSVLRRVSHRYIVQLMEIFETEDQVYMVMELATGGELFDRLIA . . .:.:. . .:..:::...:. :: : .:.:. ...:.::.:..:::::::.. XP_006 CIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVE 60 70 80 90 100 110 160 170 180 190 200 210 pF1KE0 QGSFTERDAVRILQMVADGIRYLHALQITHRNLKPENLLYYHPGEESKILITDFGLA-YS .: .::.:: ....: :.. ::: . :.::.::::::::: :::::.:.::::. . XP_006 KGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKME 120 130 140 150 160 170 220 230 240 250 260 270 pF1KE0 GKKSGDWTMKTLCGTPEYIAPEVLLRKPYTSAVDMWALGVITYALLSGFLPFDDESQTRL :: :: .:.: :::: :.::::: .:::..::: :..:::.: :: :. :: ::....: XP_006 GK--GD-VMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKL 180 190 200 210 220 280 290 300 310 320 pF1KE0 YRKILKGKYNYTGEPWPSISHLAKDFIDKLLILEAGHRMSAGQALDHPWVITMAAGSSM- ...:::..:.. . : .:: ::::: .:. . ..:.. :: :::. ::.. XP_006 FEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWI----AGDTAL 230 240 250 260 270 280 330 340 350 360 370 380 pF1KE0 -KNLQRAISRNLMQRASPHSQSPGSAQSSKSHYSHKSRHMWSKRNLRIVESPLSALL ::.....: XP_006 NKNIHESVSAQIRKNFAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQK 290 300 310 320 330 340 >>NP_065130 (OMIM: 607957) calcium/calmodulin-dependent (357 aa) initn: 828 init1: 378 opt: 852 Z-score: 382.4 bits: 79.4 E(85289): 1.5e-14 Smith-Waterman score: 852; 46.2% identity (78.1% similar) in 279 aa overlap (63-337:23-294) 40 50 60 70 80 90 pF1KE0 GPGPEAAAQAAQRIQVARFRAKFDPRVLARYDIKALIGTGSFSRVVRVEQKTTKKPFAIK ...: .:::.::.:: .:.:.: : ::.: NP_065 MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVK 10 20 30 40 50 100 110 120 130 140 150 pF1KE0 VMETREREGREACV-SELSVLRRVSHRYIVQLMEIFETEDQVYMVMELATGGELFDRLIA . . .:.:. . .:..:::...:. :: : .:.:. ...:.::.:..:::::::.. NP_065 CIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVE 60 70 80 90 100 110 160 170 180 190 200 210 pF1KE0 QGSFTERDAVRILQMVADGIRYLHALQITHRNLKPENLLYYHPGEESKILITDFGLA-YS .: .::.:: ....: :.. ::: . :.::.::::::::: :::::.:.::::. . NP_065 KGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKME 120 130 140 150 160 170 220 230 240 250 260 270 pF1KE0 GKKSGDWTMKTLCGTPEYIAPEVLLRKPYTSAVDMWALGVITYALLSGFLPFDDESQTRL :: :: .:.: :::: :.::::: .:::..::: :..:::.: :: :. :: ::....: NP_065 GK--GD-VMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKL 180 190 200 210 220 280 290 300 310 320 pF1KE0 YRKILKGKYNYTGEPWPSISHLAKDFIDKLLILEAGHRMSAGQALDHPWVITMAAGSSM- ...:::..:.. . : .:: ::::: .:. . ..:.. :: :::. ::.. NP_065 FEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWI----AGDTAL 230 240 250 260 270 280 330 340 350 360 370 380 pF1KE0 -KNLQRAISRNLMQRASPHSQSPGSAQSSKSHYSHKSRHMWSKRNLRIVESPLSALL ::.....: NP_065 NKNIHESVSAQIRKNFAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQK 290 300 310 320 330 340 >>XP_006717545 (OMIM: 607957) PREDICTED: calcium/calmodu (362 aa) initn: 805 init1: 378 opt: 852 Z-score: 382.4 bits: 79.4 E(85289): 1.5e-14 Smith-Waterman score: 852; 46.2% identity (78.1% similar) in 279 aa overlap (63-337:23-294) 40 50 60 70 80 90 pF1KE0 GPGPEAAAQAAQRIQVARFRAKFDPRVLARYDIKALIGTGSFSRVVRVEQKTTKKPFAIK ...: .:::.::.:: .:.:.: : ::.: XP_006 MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVK 10 20 30 40 50 100 110 120 130 140 150 pF1KE0 VMETREREGREACV-SELSVLRRVSHRYIVQLMEIFETEDQVYMVMELATGGELFDRLIA . . .:.:. . .:..:::...:. :: : .:.:. ...:.::.:..:::::::.. XP_006 CIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVE 60 70 80 90 100 110 160 170 180 190 200 210 pF1KE0 QGSFTERDAVRILQMVADGIRYLHALQITHRNLKPENLLYYHPGEESKILITDFGLA-YS .: .::.:: ....: :.. ::: . :.::.::::::::: :::::.:.::::. . XP_006 KGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKME 120 130 140 150 160 170 220 230 240 250 260 270 pF1KE0 GKKSGDWTMKTLCGTPEYIAPEVLLRKPYTSAVDMWALGVITYALLSGFLPFDDESQTRL :: :: .:.: :::: :.::::: .:::..::: :..:::.: :: :. :: ::....: XP_006 GK--GD-VMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKL 180 190 200 210 220 280 290 300 310 320 pF1KE0 YRKILKGKYNYTGEPWPSISHLAKDFIDKLLILEAGHRMSAGQALDHPWVITMAAGSSM- ...:::..:.. . : .:: ::::: .:. . ..:.. :: :::. ::.. XP_006 FEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWI----AGDTAL 230 240 250 260 270 280 330 340 350 360 370 380 pF1KE0 -KNLQRAISRNLMQRASPHSQSPGSAQSSKSHYSHKSRHMWSKRNLRIVESPLSALL ::.....: XP_006 NKNIHESVSAQIRKNFAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNVWHLPRSVVSFLL 290 300 310 320 330 340 >>NP_705718 (OMIM: 607957) calcium/calmodulin-dependent (385 aa) initn: 828 init1: 378 opt: 852 Z-score: 382.1 bits: 79.5 E(85289): 1.5e-14 Smith-Waterman score: 852; 46.2% identity (78.1% similar) in 279 aa overlap (63-337:23-294) 40 50 60 70 80 90 pF1KE0 GPGPEAAAQAAQRIQVARFRAKFDPRVLARYDIKALIGTGSFSRVVRVEQKTTKKPFAIK ...: .:::.::.:: .:.:.: : ::.: NP_705 MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVK 10 20 30 40 50 100 110 120 130 140 150 pF1KE0 VMETREREGREACV-SELSVLRRVSHRYIVQLMEIFETEDQVYMVMELATGGELFDRLIA . . .:.:. . .:..:::...:. :: : .:.:. ...:.::.:..:::::::.. NP_705 CIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVE 60 70 80 90 100 110 160 170 180 190 200 210 pF1KE0 QGSFTERDAVRILQMVADGIRYLHALQITHRNLKPENLLYYHPGEESKILITDFGLA-YS .: .::.:: ....: :.. ::: . :.::.::::::::: :::::.:.::::. . NP_705 KGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKME 120 130 140 150 160 170 220 230 240 250 260 270 pF1KE0 GKKSGDWTMKTLCGTPEYIAPEVLLRKPYTSAVDMWALGVITYALLSGFLPFDDESQTRL :: :: .:.: :::: :.::::: .:::..::: :..:::.: :: :. :: ::....: NP_705 GK--GD-VMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKL 180 190 200 210 220 280 290 300 310 320 pF1KE0 YRKILKGKYNYTGEPWPSISHLAKDFIDKLLILEAGHRMSAGQALDHPWVITMAAGSSM- ...:::..:.. . : .:: ::::: .:. . ..:.. :: :::. ::.. NP_705 FEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWI----AGDTAL 230 240 250 260 270 280 330 340 350 360 370 380 pF1KE0 -KNLQRAISRNLMQRASPHSQSPGSAQSSKSHYSHKSRHMWSKRNLRIVESPLSALL ::.....: NP_705 NKNIHESVSAQIRKNFAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQK 290 300 310 320 330 340 >>NP_001034671 (OMIM: 300680) calcium/calmodulin-depende (426 aa) initn: 717 init1: 368 opt: 836 Z-score: 375.3 bits: 78.3 E(85289): 3.6e-14 Smith-Waterman score: 836; 40.2% identity (68.9% similar) in 351 aa overlap (4-344:38-383) 10 20 30 pF1KE0 MGCGASRKVVPGP---PALAWAKHEGQNQAGVG : :.. :: :: .. .. ..:.: NP_001 VAGSACPRRGGEGRDWKAESLADLWPKSSPGDSHRWCKGPGAGPAGPQLREAARASSGLG 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE0 GAGPGPEAAAQAAQRIQVARFRAKFDPRVLARYDIKALIGTGSFSRVVRVEQKTTKKPFA :.: : : .: . : . . :.:. .:.:.::.:: .... . . : NP_001 GGGRHPSRIPAIA--LQDMLLLKKHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVA 70 80 90 100 110 120 100 110 120 130 140 pF1KE0 IKVMETREREGREACV-SELSVLRRVSHRYIVQLMEIFETEDQVYMVMELATGGELFDRL .: . . .:.:: : .:..::::.:: :: : .. :. ...:..:::.::::::::. NP_001 LKCIPKKALRGKEALVENEIAVLRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRI 130 140 150 160 170 180 150 160 170 180 190 200 pF1KE0 IAQGSFTERDAVRILQMVADGIRYLHALQITHRNLKPENLLYYHPGEESKILITDFGLAY . .::.::.:: ... .: .. :::.: :.::.:::::::: : :.:::...:::: NP_001 MERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGL-- 190 200 210 220 230 240 210 220 230 240 250 260 pF1KE0 SGKKSGDWTMKTLCGTPEYIAPEVLLRKPYTSAVDMWALGVITYALLSGFLPFDDESQTR : ..:. . : :::: :.:::.: .::: .:::.::::::.: :: :. :: :::. . NP_001 SKIQAGNM-LGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPE 250 260 270 280 290 300 270 280 290 300 310 320 pF1KE0 LYRKILKGKYNYTGEPWPSISHLAKDFIDKLLILEAGHRMSAGQALDHPWVITMAA---- :. .::...:.. . : .::. ::::: .:: . .:.. ::: : :. .: NP_001 LFSQILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRD 310 320 330 340 350 360 330 340 350 360 370 380 pF1KE0 --GSSMKNLQRAISRNLMQRASPHSQSPGSAQSSKSHYSHKSRHMWSKRNLRIVESPLSA :: ..... ..:. .:: NP_001 ILGSVSEQIRKNFARTHWKRAFNATSFLRHIRKLGQIPEGEGASEQGMARHSHSGLRAGQ 370 380 390 400 410 420 >>XP_016884766 (OMIM: 300680) PREDICTED: calcium/calmodu (426 aa) initn: 717 init1: 368 opt: 836 Z-score: 375.3 bits: 78.3 E(85289): 3.6e-14 Smith-Waterman score: 836; 40.2% identity (68.9% similar) in 351 aa overlap (4-344:38-383) 10 20 30 pF1KE0 MGCGASRKVVPGP---PALAWAKHEGQNQAGVG : :.. :: :: .. .. ..:.: XP_016 VAGSACPRRGGEGRDWKAESLADLWPKSSPGDSHRWCKGPGAGPAGPQLREAARASSGLG 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE0 GAGPGPEAAAQAAQRIQVARFRAKFDPRVLARYDIKALIGTGSFSRVVRVEQKTTKKPFA :.: : : .: . : . . :.:. .:.:.::.:: .... . . : XP_016 GGGRHPSRIPAIA--LQDMLLLKKHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVA 70 80 90 100 110 120 100 110 120 130 140 pF1KE0 IKVMETREREGREACV-SELSVLRRVSHRYIVQLMEIFETEDQVYMVMELATGGELFDRL .: . . .:.:: : .:..::::.:: :: : .. :. ...:..:::.::::::::. XP_016 LKCIPKKALRGKEALVENEIAVLRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRI 130 140 150 160 170 180 150 160 170 180 190 200 pF1KE0 IAQGSFTERDAVRILQMVADGIRYLHALQITHRNLKPENLLYYHPGEESKILITDFGLAY . .::.::.:: ... .: .. :::.: :.::.:::::::: : :.:::...:::: XP_016 MERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGL-- 190 200 210 220 230 240 210 220 230 240 250 260 pF1KE0 SGKKSGDWTMKTLCGTPEYIAPEVLLRKPYTSAVDMWALGVITYALLSGFLPFDDESQTR : ..:. . : :::: :.:::.: .::: .:::.::::::.: :: :. :: :::. . XP_016 SKIQAGNM-LGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPE 250 260 270 280 290 300 270 280 290 300 310 320 pF1KE0 LYRKILKGKYNYTGEPWPSISHLAKDFIDKLLILEAGHRMSAGQALDHPWVITMAA---- :. .::...:.. . : .::. ::::: .:: . .:.. ::: : :. .: XP_016 LFSQILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRD 310 320 330 340 350 360 330 340 350 360 370 380 pF1KE0 --GSSMKNLQRAISRNLMQRASPHSQSPGSAQSSKSHYSHKSRHMWSKRNLRIVESPLSA :: ..... ..:. .:: XP_016 ILGSVSEQIRKNFARTHWKRAFNATSFLRHIRKLGQIPEGEGASEQGMARHSHSGLRAGQ 370 380 390 400 410 420 >>NP_003647 (OMIM: 604998) calcium/calmodulin-dependent (370 aa) initn: 830 init1: 366 opt: 833 Z-score: 374.6 bits: 78.0 E(85289): 4e-14 Smith-Waterman score: 833; 43.6% identity (75.8% similar) in 298 aa overlap (46-340:5-294) 20 30 40 50 60 70 pF1KE0 LAWAKHEGQNQAGVGGAGPGPEAAAQAAQRIQVARFRAKFDPRVLARYDIKALIGTGSFS .. :.. : : . ::.. ..:::.:: NP_003 MLGAVEGPRWKQAEDIRDI--YDFRDVLGTGAFS 10 20 30 80 90 100 110 120 130 pF1KE0 RVVRVEQKTTKKPFAIKVMETREREGREACV-SELSVLRRVSHRYIVQLMEIFETEDQVY .:. .:.: :.: ::: . . ::.:. . .:..::....: :: : .:.:. ..: NP_003 EVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKHPNIVALDDIYESGGHLY 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE0 MVMELATGGELFDRLIAQGSFTERDAVRILQMVADGIRYLHALQITHRNLKPENLLYYHP ..:.:..:::::::.. .: .::::: :.. .: :...::: : :.::.::::::::: NP_003 LIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSL 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE0 GEESKILITDFGLAYSGKKSGDWTMKTLCGTPEYIAPEVLLRKPYTSAVDMWALGVITYA :.:::.:.:::: : .. ...: :::: :.::::: .:::..::: :..:::.: NP_003 DEDSKIMISDFGL--SKMEDPGSVLSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYI 160 170 180 190 200 210 260 270 280 290 300 310 pF1KE0 LLSGFLPFDDESQTRLYRKILKGKYNYTGEPWPSISHLAKDFIDKLLILEAGHRMSAGQA :: :. :: ::....:...:::..:.. . : .:: ::::: .:. . .:.. :: NP_003 LLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQA 220 230 240 250 260 270 320 330 340 350 360 370 pF1KE0 LDHPWVITMAAGSSM--KNLQRAISRNLMQRASPHSQSPGSAQSSKSHYSHKSRHMWSKR :.:::. ::.. ::.....:... NP_003 LQHPWI----AGDTALDKNIHQSVSEQIKKNFAKSKWKQAFNATAVVRHMRKLQLGTSQE 280 290 300 310 320 >>XP_005265573 (OMIM: 604998) PREDICTED: calcium/calmodu (413 aa) initn: 845 init1: 366 opt: 833 Z-score: 374.2 bits: 78.1 E(85289): 4.2e-14 Smith-Waterman score: 833; 43.6% identity (75.8% similar) in 298 aa overlap (46-340:5-294) 20 30 40 50 60 70 pF1KE0 LAWAKHEGQNQAGVGGAGPGPEAAAQAAQRIQVARFRAKFDPRVLARYDIKALIGTGSFS .. :.. : : . ::.. ..:::.:: XP_005 MLGAVEGPRWKQAEDIRDI--YDFRDVLGTGAFS 10 20 30 80 90 100 110 120 130 pF1KE0 RVVRVEQKTTKKPFAIKVMETREREGREACV-SELSVLRRVSHRYIVQLMEIFETEDQVY .:. .:.: :.: ::: . . ::.:. . .:..::....: :: : .:.:. ..: XP_005 EVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKHPNIVALDDIYESGGHLY 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE0 MVMELATGGELFDRLIAQGSFTERDAVRILQMVADGIRYLHALQITHRNLKPENLLYYHP ..:.:..:::::::.. .: .::::: :.. .: :...::: : :.::.::::::::: XP_005 LIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSL 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE0 GEESKILITDFGLAYSGKKSGDWTMKTLCGTPEYIAPEVLLRKPYTSAVDMWALGVITYA :.:::.:.:::: : .. ...: :::: :.::::: .:::..::: :..:::.: XP_005 DEDSKIMISDFGL--SKMEDPGSVLSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYI 160 170 180 190 200 210 260 270 280 290 300 310 pF1KE0 LLSGFLPFDDESQTRLYRKILKGKYNYTGEPWPSISHLAKDFIDKLLILEAGHRMSAGQA :: :. :: ::....:...:::..:.. . : .:: ::::: .:. . .:.. :: XP_005 LLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQA 220 230 240 250 260 270 320 330 340 350 360 370 pF1KE0 LDHPWVITMAAGSSM--KNLQRAISRNLMQRASPHSQSPGSAQSSKSHYSHKSRHMWSKR :.:::. ::.. ::.....:... XP_005 LQHPWI----AGDTALDKNIHQSVSEQIKKNFAKSKWKQAFNATAVVRHMRKLQLGTSQE 280 290 300 310 320 >>XP_006717544 (OMIM: 607957) PREDICTED: calcium/calmodu (366 aa) initn: 806 init1: 378 opt: 829 Z-score: 373.0 bits: 77.7 E(85289): 4.9e-14 Smith-Waterman score: 829; 46.5% identity (78.2% similar) in 271 aa overlap (71-337:12-275) 50 60 70 80 90 100 pF1KE0 QAAQRIQVARFRAKFDPRVLARYDIKALIGTGSFSRVVRVEQKTTKKPFAIKVMETRERE .:.::.:: .:.:.: : ::.: . . . XP_006 MNVDLLSCALWSGAFSEVVLAEEKATGKLFAVKCIPKKALK 10 20 30 40 110 120 130 140 150 pF1KE0 GREACV-SELSVLRRVSHRYIVQLMEIFETEDQVYMVMELATGGELFDRLIAQGSFTERD :.:. . .:..:::...:. :: : .:.:. ...:.::.:..:::::::.. .: .::.: XP_006 GKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKD 50 60 70 80 90 100 160 170 180 190 200 210 pF1KE0 AVRILQMVADGIRYLHALQITHRNLKPENLLYYHPGEESKILITDFGLA-YSGKKSGDWT : ....: :.. ::: . :.::.::::::::: :::::.:.::::. . :: :: . XP_006 ASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGK--GD-V 110 120 130 140 150 220 230 240 250 260 270 pF1KE0 MKTLCGTPEYIAPEVLLRKPYTSAVDMWALGVITYALLSGFLPFDDESQTRLYRKILKGK :.: :::: :.::::: .:::..::: :..:::.: :: :. :: ::....:...:::.. XP_006 MSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAE 160 170 180 190 200 210 280 290 300 310 320 330 pF1KE0 YNYTGEPWPSISHLAKDFIDKLLILEAGHRMSAGQALDHPWVITMAAGSSM--KNLQRAI :.. . : .:: ::::: .:. . ..:.. :: :::. ::.. ::..... XP_006 YEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWI----AGDTALNKNIHESV 220 230 240 250 260 270 340 350 360 370 380 pF1KE0 SRNLMQRASPHSQSPGSAQSSKSHYSHKSRHMWSKRNLRIVESPLSALL : XP_006 SAQIRKNFAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQKDCLAPSTL 280 290 300 310 320 330 385 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 18 17:34:52 2016 done: Fri Nov 18 17:34:53 2016 Total Scan time: 8.760 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]