FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0951, 473 aa 1>>>pF1KE0951 473 - 473 aa - 473 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.3590+/-0.000663; mu= -7.0687+/- 0.039 mean_var=599.4896+/-136.090, 0's: 0 Z-trim(115.4): 1688 B-trim: 509 in 1/51 Lambda= 0.052382 statistics sampled from 23519 (25908) to 23519 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.661), E-opt: 0.2 (0.304), width: 16 Scan time: 10.170 The best scores are: opt bits E(85289) NP_001310303 (OMIM: 114080) calcium/calmodulin-dep ( 473) 3092 249.7 1.3e-65 NP_001310304 (OMIM: 114080) calcium/calmodulin-dep ( 473) 3092 249.7 1.3e-65 NP_001735 (OMIM: 114080) calcium/calmodulin-depend ( 473) 3092 249.7 1.3e-65 NP_001310306 (OMIM: 114080) calcium/calmodulin-dep ( 276) 1836 154.4 3.6e-37 NP_001310305 (OMIM: 114080) calcium/calmodulin-dep ( 276) 1836 154.4 3.6e-37 XP_005265573 (OMIM: 604998) PREDICTED: calcium/cal ( 413) 941 87.1 1e-16 NP_001129212 (OMIM: 300680) calcium/calmodulin-dep ( 360) 935 86.5 1.3e-16 XP_016884766 (OMIM: 300680) PREDICTED: calcium/cal ( 426) 935 86.6 1.4e-16 NP_001034671 (OMIM: 300680) calcium/calmodulin-dep ( 426) 935 86.6 1.4e-16 XP_011529410 (OMIM: 300680) PREDICTED: calcium/cal ( 361) 933 86.4 1.5e-16 XP_011529414 (OMIM: 300680) PREDICTED: calcium/cal ( 343) 931 86.2 1.6e-16 XP_011529412 (OMIM: 300680) PREDICTED: calcium/cal ( 343) 931 86.2 1.6e-16 XP_005274708 (OMIM: 300680) PREDICTED: calcium/cal ( 343) 931 86.2 1.6e-16 XP_016884768 (OMIM: 300680) PREDICTED: calcium/cal ( 343) 931 86.2 1.6e-16 XP_006724872 (OMIM: 300680) PREDICTED: calcium/cal ( 343) 931 86.2 1.6e-16 XP_011529413 (OMIM: 300680) PREDICTED: calcium/cal ( 343) 931 86.2 1.6e-16 XP_011529409 (OMIM: 300680) PREDICTED: calcium/cal ( 343) 931 86.2 1.6e-16 XP_016884767 (OMIM: 300680) PREDICTED: calcium/cal ( 343) 931 86.2 1.6e-16 NP_003647 (OMIM: 604998) calcium/calmodulin-depend ( 370) 927 85.9 2e-16 XP_006717546 (OMIM: 607957) PREDICTED: calcium/cal ( 355) 921 85.4 2.7e-16 NP_065130 (OMIM: 607957) calcium/calmodulin-depend ( 357) 921 85.5 2.7e-16 NP_705718 (OMIM: 607957) calcium/calmodulin-depend ( 385) 921 85.5 2.8e-16 XP_006717545 (OMIM: 607957) PREDICTED: calcium/cal ( 362) 911 84.7 4.6e-16 XP_006717544 (OMIM: 607957) PREDICTED: calcium/cal ( 366) 897 83.7 9.7e-16 XP_011517893 (OMIM: 607957) PREDICTED: calcium/cal ( 372) 896 83.6 1e-15 NP_065172 (OMIM: 614994) calcium/calmodulin-depend ( 476) 886 83.0 2e-15 XP_016857355 (OMIM: 614994) PREDICTED: calcium/cal ( 476) 886 83.0 2e-15 XP_005265574 (OMIM: 604998) PREDICTED: calcium/cal ( 369) 875 82.0 3.1e-15 XP_016862843 (OMIM: 604998) PREDICTED: calcium/cal ( 326) 861 80.9 6e-15 NP_001308509 (OMIM: 607708) calcium/calmodulin-dep ( 519) 856 80.8 1e-14 NP_742127 (OMIM: 607708) calcium/calmodulin-depend ( 489) 852 80.4 1.2e-14 XP_011530593 (OMIM: 607708) PREDICTED: calcium/cal ( 489) 852 80.4 1.2e-14 NP_001308511 (OMIM: 607708) calcium/calmodulin-dep ( 489) 852 80.4 1.2e-14 XP_011530591 (OMIM: 607708) PREDICTED: calcium/cal ( 510) 852 80.5 1.2e-14 NP_742112 (OMIM: 607708) calcium/calmodulin-depend ( 492) 851 80.4 1.3e-14 NP_001308519 (OMIM: 607708) calcium/calmodulin-dep ( 492) 851 80.4 1.3e-14 NP_001308518 (OMIM: 607708) calcium/calmodulin-dep ( 492) 851 80.4 1.3e-14 NP_001308495 (OMIM: 607708) calcium/calmodulin-dep ( 513) 851 80.4 1.3e-14 NP_001308516 (OMIM: 607708) calcium/calmodulin-dep ( 503) 850 80.3 1.4e-14 NP_001308520 (OMIM: 607708) calcium/calmodulin-dep ( 503) 850 80.3 1.4e-14 XP_011530597 (OMIM: 607708) PREDICTED: calcium/cal ( 510) 850 80.3 1.4e-14 NP_001308502 (OMIM: 607708) calcium/calmodulin-dep ( 524) 850 80.3 1.4e-14 NP_001308504 (OMIM: 607708) calcium/calmodulin-dep ( 492) 849 80.2 1.4e-14 NP_001308512 (OMIM: 607708) calcium/calmodulin-dep ( 492) 849 80.2 1.4e-14 XP_016864161 (OMIM: 607708) PREDICTED: calcium/cal ( 513) 849 80.2 1.4e-14 NP_001308513 (OMIM: 607708) calcium/calmodulin-dep ( 491) 848 80.1 1.5e-14 NP_001308497 (OMIM: 607708) calcium/calmodulin-dep ( 503) 848 80.2 1.5e-14 XP_011517894 (OMIM: 607957) PREDICTED: calcium/cal ( 315) 843 79.5 1.5e-14 NP_001308517 (OMIM: 607708) calcium/calmodulin-dep ( 512) 848 80.2 1.5e-14 NP_742126 (OMIM: 607708) calcium/calmodulin-depend ( 478) 847 80.1 1.5e-14 >>NP_001310303 (OMIM: 114080) calcium/calmodulin-depende (473 aa) initn: 3092 init1: 3092 opt: 3092 Z-score: 1299.0 bits: 249.7 E(85289): 1.3e-65 Smith-Waterman score: 3092; 100.0% identity (100.0% similar) in 473 aa overlap (1-473:1-473) 10 20 30 40 50 60 pF1KE0 MLKVTVPSCSASSCSSVTASAAPGTASLVPDYWIDGSNRDALSDFFEVESELGRGATSIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLKVTVPSCSASSCSSVTASAAPGTASLVPDYWIDGSNRDALSDFFEVESELGRGATSIV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 YRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 VTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 LKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 FYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 TGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRLGSASSSHGSIQESHKASRDPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRLGSASSSHGSIQESHKASRDPS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 PIQDGNEDMKAIPEGEKIQGDGAQAAVKGAQAELMKVQALEKVKGADINAEEAPKMVPKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PIQDGNEDMKAIPEGEKIQGDGAQAAVKGAQAELMKVQALEKVKGADINAEEAPKMVPKA 370 380 390 400 410 420 430 440 450 460 470 pF1KE0 VEDGIKVADLELEEGLAEEKLKTVEEAAAPREGQGSSAVGFEVPQQDVILPEY ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VEDGIKVADLELEEGLAEEKLKTVEEAAAPREGQGSSAVGFEVPQQDVILPEY 430 440 450 460 470 >>NP_001310304 (OMIM: 114080) calcium/calmodulin-depende (473 aa) initn: 3092 init1: 3092 opt: 3092 Z-score: 1299.0 bits: 249.7 E(85289): 1.3e-65 Smith-Waterman score: 3092; 100.0% identity (100.0% similar) in 473 aa overlap (1-473:1-473) 10 20 30 40 50 60 pF1KE0 MLKVTVPSCSASSCSSVTASAAPGTASLVPDYWIDGSNRDALSDFFEVESELGRGATSIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLKVTVPSCSASSCSSVTASAAPGTASLVPDYWIDGSNRDALSDFFEVESELGRGATSIV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 YRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 VTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 LKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 FYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 TGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRLGSASSSHGSIQESHKASRDPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRLGSASSSHGSIQESHKASRDPS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 PIQDGNEDMKAIPEGEKIQGDGAQAAVKGAQAELMKVQALEKVKGADINAEEAPKMVPKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PIQDGNEDMKAIPEGEKIQGDGAQAAVKGAQAELMKVQALEKVKGADINAEEAPKMVPKA 370 380 390 400 410 420 430 440 450 460 470 pF1KE0 VEDGIKVADLELEEGLAEEKLKTVEEAAAPREGQGSSAVGFEVPQQDVILPEY ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VEDGIKVADLELEEGLAEEKLKTVEEAAAPREGQGSSAVGFEVPQQDVILPEY 430 440 450 460 470 >>NP_001735 (OMIM: 114080) calcium/calmodulin-dependent (473 aa) initn: 3092 init1: 3092 opt: 3092 Z-score: 1299.0 bits: 249.7 E(85289): 1.3e-65 Smith-Waterman score: 3092; 100.0% identity (100.0% similar) in 473 aa overlap (1-473:1-473) 10 20 30 40 50 60 pF1KE0 MLKVTVPSCSASSCSSVTASAAPGTASLVPDYWIDGSNRDALSDFFEVESELGRGATSIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLKVTVPSCSASSCSSVTASAAPGTASLVPDYWIDGSNRDALSDFFEVESELGRGATSIV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 YRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 VTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 LKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 FYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 TGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRLGSASSSHGSIQESHKASRDPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRLGSASSSHGSIQESHKASRDPS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 PIQDGNEDMKAIPEGEKIQGDGAQAAVKGAQAELMKVQALEKVKGADINAEEAPKMVPKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PIQDGNEDMKAIPEGEKIQGDGAQAAVKGAQAELMKVQALEKVKGADINAEEAPKMVPKA 370 380 390 400 410 420 430 440 450 460 470 pF1KE0 VEDGIKVADLELEEGLAEEKLKTVEEAAAPREGQGSSAVGFEVPQQDVILPEY ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VEDGIKVADLELEEGLAEEKLKTVEEAAAPREGQGSSAVGFEVPQQDVILPEY 430 440 450 460 470 >>NP_001310306 (OMIM: 114080) calcium/calmodulin-depende (276 aa) initn: 1836 init1: 1836 opt: 1836 Z-score: 788.3 bits: 154.4 E(85289): 3.6e-37 Smith-Waterman score: 1836; 100.0% identity (100.0% similar) in 276 aa overlap (198-473:1-276) 170 180 190 200 210 220 pF1KE0 ENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSV :::::::::::::::::::::::::::::: NP_001 MKTVCGTPGYCAPEILRGCAYGPEVDMWSV 10 20 30 230 240 250 260 270 280 pF1KE0 GIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKK 40 50 60 70 80 90 290 300 310 320 330 340 pF1KE0 RLTTFQALQHPWVTGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRLGSASSSHG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLTTFQALQHPWVTGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRLGSASSSHG 100 110 120 130 140 150 350 360 370 380 390 400 pF1KE0 SIQESHKASRDPSPIQDGNEDMKAIPEGEKIQGDGAQAAVKGAQAELMKVQALEKVKGAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SIQESHKASRDPSPIQDGNEDMKAIPEGEKIQGDGAQAAVKGAQAELMKVQALEKVKGAD 160 170 180 190 200 210 410 420 430 440 450 460 pF1KE0 INAEEAPKMVPKAVEDGIKVADLELEEGLAEEKLKTVEEAAAPREGQGSSAVGFEVPQQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 INAEEAPKMVPKAVEDGIKVADLELEEGLAEEKLKTVEEAAAPREGQGSSAVGFEVPQQD 220 230 240 250 260 270 470 pF1KE0 VILPEY :::::: NP_001 VILPEY >>NP_001310305 (OMIM: 114080) calcium/calmodulin-depende (276 aa) initn: 1836 init1: 1836 opt: 1836 Z-score: 788.3 bits: 154.4 E(85289): 3.6e-37 Smith-Waterman score: 1836; 100.0% identity (100.0% similar) in 276 aa overlap (198-473:1-276) 170 180 190 200 210 220 pF1KE0 ENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSV :::::::::::::::::::::::::::::: NP_001 MKTVCGTPGYCAPEILRGCAYGPEVDMWSV 10 20 30 230 240 250 260 270 280 pF1KE0 GIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKK 40 50 60 70 80 90 290 300 310 320 330 340 pF1KE0 RLTTFQALQHPWVTGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRLGSASSSHG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLTTFQALQHPWVTGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRLGSASSSHG 100 110 120 130 140 150 350 360 370 380 390 400 pF1KE0 SIQESHKASRDPSPIQDGNEDMKAIPEGEKIQGDGAQAAVKGAQAELMKVQALEKVKGAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SIQESHKASRDPSPIQDGNEDMKAIPEGEKIQGDGAQAAVKGAQAELMKVQALEKVKGAD 160 170 180 190 200 210 410 420 430 440 450 460 pF1KE0 INAEEAPKMVPKAVEDGIKVADLELEEGLAEEKLKTVEEAAAPREGQGSSAVGFEVPQQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 INAEEAPKMVPKAVEDGIKVADLELEEGLAEEKLKTVEEAAAPREGQGSSAVGFEVPQQD 220 230 240 250 260 270 470 pF1KE0 VILPEY :::::: NP_001 VILPEY >>XP_005265573 (OMIM: 604998) PREDICTED: calcium/calmodu (413 aa) initn: 923 init1: 633 opt: 941 Z-score: 421.0 bits: 87.1 E(85289): 1e-16 Smith-Waterman score: 941; 44.1% identity (72.6% similar) in 358 aa overlap (42-389:16-366) 20 30 40 50 60 70 pF1KE0 SSCSSVTASAAPGTASLVPDYWIDGSNRDALSDFFEVESELGRGATSIVYRCKQKGTQKP . :... .. :: :: : : ..: ::: XP_005 MLGAVEGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKL 10 20 30 40 80 90 100 110 120 pF1KE0 YALK-VLKKTVDKK--IVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFD :.: . :.... : ...::.:: ...::::. : .:.:. .. :...::.:::::: XP_005 VAIKCIAKEALEGKEGSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFD 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE0 RIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGL ::::::.:.::::. . :.:.:: :::. :::::::::::::: . :. . :.:::: XP_005 RIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGL 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE0 SKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQ ::. . ...:.:::::: :::.: :. :: ::.:.:.::::::. ::::: .: XP_005 SKMEDPGSVLSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDE-NDA 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE0 FMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWVTGKAA--N .:..::. :: : ::.::..: .:::..:.:. ::.::.: :::::::..: .: . XP_005 KLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDK 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE0 FVHMDTAQKKLQEFNARRKLKAAVKA--VVASSR---LGSASSSHGSIQESHKASRDPSP .:...... ..: :. : : : .: :: : ::... ..:. :: .. .: XP_005 NIHQSVSEQIKKNF-AKSKWKQAFNATAVVRHMRKLQLGTSQEGQGQTA-SH--GELLTP 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE0 IQDGNEDMKAIPEGEKIQGDGAQAAVKGAQAELMKVQALEKVKGADINAEEAPKMVPKAV . :.: .:. .: ..:.:.: XP_005 VAGGEE--RALQKGMGGPQRCTRAGVEGLPLRPPLFCLPMQGRQLAVAVETAAWSRAQNC 350 360 370 380 390 >>NP_001129212 (OMIM: 300680) calcium/calmodulin-depende (360 aa) initn: 885 init1: 449 opt: 935 Z-score: 419.1 bits: 86.5 E(85289): 1.3e-16 Smith-Waterman score: 935; 43.8% identity (71.6% similar) in 352 aa overlap (24-361:8-357) 10 20 30 40 50 pF1KE0 MLKVTVPSCSASSCSSVTASAAPGTASLVP--DYWIDGSNRDALSDFFEVESELGRGATS : :. : :. . .. . .:. .:.. .:: :: : NP_001 MWRRVCGGLAGRRPSGDMLLLKKHTEDISSVYEIRERLGSGAFS 10 20 30 40 60 70 80 90 100 110 pF1KE0 IVYRCKQKGTQKPYALKVL-KKTVDKK--IVRTEIGVLLRLSHPNIIKLKEIFETPTEIS : ...:. . ::: . ::.. : .:..::.:: :.:::::. :... :.:... NP_001 EVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRISHPNIVALEDVHESPSHLY 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE0 LVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATP :..::::::::::::.:.: :.:.::. : :.: ::.::: ::::::::::::::::: NP_001 LAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATP 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE0 APDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILL :. . ..::::::: . .. :.:::::: :::.:. :: ::.:..:.:.:::: NP_001 FEDSKIMVSDFGLSKI-QAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILL 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE0 CGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQAL ::. ::::: .: .: .:: : : ::.::..: .:::..:.:. ::.::.: ::: NP_001 CGYPPFYDE-SDPELFSQILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQAL 230 240 250 260 270 280 300 310 320 330 340 pF1KE0 QHPWVTGKAA-NFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRL--------GSASSSH .: :..: .: . . ........ :: . : : .:. .. : ..: . NP_001 RHLWISGDTAFDRDILGSVSEQIRKNFARTHWKRAFNATSFLRHIRKLGQIPEGEGASEQ 290 300 310 320 330 340 350 360 370 380 390 400 pF1KE0 GSIQESHKASRDPSPIQDGNEDMKAIPEGEKIQGDGAQAAVKGAQAELMKVQALEKVKGA : ..::.. : .: NP_001 GMARHSHSGLRAGQPPKW 350 360 >>XP_016884766 (OMIM: 300680) PREDICTED: calcium/calmodu (426 aa) initn: 885 init1: 449 opt: 935 Z-score: 418.4 bits: 86.6 E(85289): 1.4e-16 Smith-Waterman score: 935; 43.5% identity (71.5% similar) in 354 aa overlap (20-361:74-423) 10 20 30 40 pF1KE0 MLKVTVPSCSASSCSSVTASAAPGTASLVPDYWIDGSNRDALSDFFEVE : :. : . :. . .. . .:. .:.. XP_016 CKGPGAGPAGPQLREAARASSGLGGGGRHPSRIPAIA--LQDMLLLKKHTEDISSVYEIR 50 60 70 80 90 100 50 60 70 80 90 100 pF1KE0 SELGRGATSIVYRCKQKGTQKPYALKVL-KKTVDKK--IVRTEIGVLLRLSHPNIIKLKE .:: :: : : ...:. . ::: . ::.. : .:..::.:: :.:::::. :.. XP_016 ERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRISHPNIVALED 110 120 130 140 150 160 110 120 130 140 150 160 pF1KE0 IFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLK . :.:... :..::::::::::::.:.: :.:.::. : :.: ::.::: :::::::: XP_016 VHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLK 170 180 190 200 210 220 170 180 190 200 210 220 pF1KE0 PENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWS ::::::::: :. . ..::::::: . .. :.:::::: :::.:. :: ::.:. XP_016 PENLLYATPFEDSKIMVSDFGLSKI-QAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWA 230 240 250 260 270 280 230 240 250 260 270 280 pF1KE0 VGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPK .:.:.::::::. ::::: .: .: .:: : : ::.::..: .:::..:.:. ::. XP_016 LGVISYILLCGYPPFYDE-SDPELFSQILRASYEFDSPFWDDISESAKDFIRHLLERDPQ 290 300 310 320 330 290 300 310 320 330 pF1KE0 KRLTTFQALQHPWVTGKAA-NFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRL------ ::.: :::.: :..: .: . . ........ :: . : : .:. .. XP_016 KRFTCQQALRHLWISGDTAFDRDILGSVSEQIRKNFARTHWKRAFNATSFLRHIRKLGQI 340 350 360 370 380 390 340 350 360 370 380 390 pF1KE0 --GSASSSHGSIQESHKASRDPSPIQDGNEDMKAIPEGEKIQGDGAQAAVKGAQAELMKV : ..: .: ..::.. : .: XP_016 PEGEGASEQGMARHSHSGLRAGQPPKW 400 410 420 >>NP_001034671 (OMIM: 300680) calcium/calmodulin-depende (426 aa) initn: 885 init1: 449 opt: 935 Z-score: 418.4 bits: 86.6 E(85289): 1.4e-16 Smith-Waterman score: 935; 43.5% identity (71.5% similar) in 354 aa overlap (20-361:74-423) 10 20 30 40 pF1KE0 MLKVTVPSCSASSCSSVTASAAPGTASLVPDYWIDGSNRDALSDFFEVE : :. : . :. . .. . .:. .:.. NP_001 CKGPGAGPAGPQLREAARASSGLGGGGRHPSRIPAIA--LQDMLLLKKHTEDISSVYEIR 50 60 70 80 90 100 50 60 70 80 90 100 pF1KE0 SELGRGATSIVYRCKQKGTQKPYALKVL-KKTVDKK--IVRTEIGVLLRLSHPNIIKLKE .:: :: : : ...:. . ::: . ::.. : .:..::.:: :.:::::. :.. NP_001 ERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRISHPNIVALED 110 120 130 140 150 160 110 120 130 140 150 160 pF1KE0 IFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLK . :.:... :..::::::::::::.:.: :.:.::. : :.: ::.::: :::::::: NP_001 VHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLK 170 180 190 200 210 220 170 180 190 200 210 220 pF1KE0 PENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWS ::::::::: :. . ..::::::: . .. :.:::::: :::.:. :: ::.:. NP_001 PENLLYATPFEDSKIMVSDFGLSKI-QAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWA 230 240 250 260 270 280 230 240 250 260 270 280 pF1KE0 VGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPK .:.:.::::::. ::::: .: .: .:: : : ::.::..: .:::..:.:. ::. NP_001 LGVISYILLCGYPPFYDE-SDPELFSQILRASYEFDSPFWDDISESAKDFIRHLLERDPQ 290 300 310 320 330 290 300 310 320 330 pF1KE0 KRLTTFQALQHPWVTGKAA-NFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRL------ ::.: :::.: :..: .: . . ........ :: . : : .:. .. NP_001 KRFTCQQALRHLWISGDTAFDRDILGSVSEQIRKNFARTHWKRAFNATSFLRHIRKLGQI 340 350 360 370 380 390 340 350 360 370 380 390 pF1KE0 --GSASSSHGSIQESHKASRDPSPIQDGNEDMKAIPEGEKIQGDGAQAAVKGAQAELMKV : ..: .: ..::.. : .: NP_001 PEGEGASEQGMARHSHSGLRAGQPPKW 400 410 420 >>XP_011529410 (OMIM: 300680) PREDICTED: calcium/calmodu (361 aa) initn: 885 init1: 449 opt: 933 Z-score: 418.3 bits: 86.4 E(85289): 1.5e-16 Smith-Waterman score: 933; 44.0% identity (72.3% similar) in 343 aa overlap (31-361:18-358) 10 20 30 40 50 60 pF1KE0 MLKVTVPSCSASSCSSVTASAAPGTASLVPDYWIDGSNRDALSDFFEVESELGRGATSIV :. . .. . .:. .:.. .:: :: : : XP_011 MISIKGMLWLLGREESEDMLLLKKHTEDISSVYEIRERLGSGAFSEV 10 20 30 40 70 80 90 100 110 pF1KE0 YRCKQKGTQKPYALKVL-KKTVDKK--IVRTEIGVLLRLSHPNIIKLKEIFETPTEISLV ...:. . ::: . ::.. : .:..::.:: :.:::::. :... :.:... :. XP_011 VLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRISHPNIVALEDVHESPSHLYLA 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE0 LELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAP .::::::::::::.:.: :.:.::. : :.: ::.::: ::::::::::::::::: XP_011 MELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFE 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE0 DAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCG :. . ..::::::: . .. :.:::::: :::.:. :: ::.:..:.:.:::::: XP_011 DSKIMVSDFGLSKI-QAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCG 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE0 FEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQH . ::::: .: .: .:: : : ::.::..: .:::..:.:. ::.::.: :::.: XP_011 YPPFYDE-SDPELFSQILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALRH 230 240 250 260 270 280 300 310 320 330 340 pF1KE0 PWVTGKAA-NFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRL--------GSASSSHGS :..: .: . . ........ :: . : : .:. .. : ..: .: XP_011 LWISGDTAFDRDILGSVSEQIRKNFARTHWKRAFNATSFLRHIRKLGQIPEGEGASEQGM 290 300 310 320 330 340 350 360 370 380 390 400 pF1KE0 IQESHKASRDPSPIQDGNEDMKAIPEGEKIQGDGAQAAVKGAQAELMKVQALEKVKGADI ..::.. : .: XP_011 ARHSHSGLRAGQPPKW 350 360 473 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 04:41:08 2016 done: Sat Nov 5 04:41:09 2016 Total Scan time: 10.170 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]