FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0963, 489 aa 1>>>pF1KE0963 489 - 489 aa - 489 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.1190+/-0.000531; mu= 5.9253+/- 0.033 mean_var=452.2204+/-104.151, 0's: 0 Z-trim(115.7): 2243 B-trim: 1098 in 1/56 Lambda= 0.060311 statistics sampled from 23573 (26387) to 23573 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.671), E-opt: 0.2 (0.309), width: 16 Scan time: 10.080 The best scores are: opt bits E(85289) NP_001139571 (OMIM: 604044) serine/threonine-prote ( 489) 3291 301.9 2.8e-81 NP_689933 (OMIM: 604044) serine/threonine-protein ( 506) 2005 190.0 1.4e-47 NP_002489 (OMIM: 604044) serine/threonine-protein ( 506) 2005 190.0 1.4e-47 XP_011530307 (OMIM: 263520,604588) PREDICTED: seri ( 715) 1094 111.0 1.2e-23 NP_001186328 (OMIM: 263520,604588) serine/threonin (1189) 1094 111.3 1.5e-23 XP_011530306 (OMIM: 263520,604588) PREDICTED: seri (1214) 1094 111.4 1.5e-23 NP_001186329 (OMIM: 263520,604588) serine/threonin (1214) 1094 111.4 1.5e-23 XP_006714291 (OMIM: 263520,604588) PREDICTED: seri (1227) 1094 111.4 1.5e-23 NP_001186327 (OMIM: 263520,604588) serine/threonin (1242) 1094 111.4 1.5e-23 NP_036356 (OMIM: 263520,604588) serine/threonine-p (1258) 1094 111.4 1.5e-23 XP_011530305 (OMIM: 263520,604588) PREDICTED: seri (1258) 1094 111.4 1.5e-23 NP_001186326 (OMIM: 263520,604588) serine/threonin (1286) 1094 111.4 1.6e-23 XP_011533370 (OMIM: 616731) PREDICTED: serine/thre ( 483) 1049 106.8 1.5e-22 XP_006719871 (OMIM: 616731) PREDICTED: serine/thre ( 598) 1049 106.9 1.6e-22 XP_011533368 (OMIM: 616731) PREDICTED: serine/thre ( 697) 1049 107.0 1.7e-22 NP_954983 (OMIM: 616731) serine/threonine-protein ( 708) 1049 107.0 1.8e-22 XP_016876045 (OMIM: 616731) PREDICTED: serine/thre ( 737) 1049 107.1 1.8e-22 XP_016876044 (OMIM: 616731) PREDICTED: serine/thre ( 755) 1049 107.1 1.8e-22 XP_016876046 (OMIM: 616731) PREDICTED: serine/thre ( 780) 1049 107.1 1.8e-22 XP_011532342 (OMIM: 601959) PREDICTED: serine/thre ( 671) 848 89.5 3.2e-17 XP_006713373 (OMIM: 601959) PREDICTED: serine/thre ( 795) 848 89.6 3.4e-17 XP_016862575 (OMIM: 601959) PREDICTED: serine/thre ( 824) 848 89.7 3.5e-17 NP_003148 (OMIM: 601959) serine/threonine-protein ( 841) 848 89.7 3.5e-17 XP_011532341 (OMIM: 601959) PREDICTED: serine/thre ( 842) 848 89.7 3.5e-17 XP_016862574 (OMIM: 601959) PREDICTED: serine/thre ( 870) 848 89.7 3.6e-17 XP_016862702 (OMIM: 609779) PREDICTED: serine/thre ( 599) 750 80.9 1.1e-14 NP_001139475 (OMIM: 609779) serine/threonine-prote ( 599) 750 80.9 1.1e-14 XP_016862703 (OMIM: 609779) PREDICTED: serine/thre ( 599) 750 80.9 1.1e-14 NP_079076 (OMIM: 609779) serine/threonine-protein ( 645) 750 81.0 1.1e-14 XP_011511469 (OMIM: 609779) PREDICTED: serine/thre ( 645) 750 81.0 1.1e-14 NP_001308149 (OMIM: 609779) serine/threonine-prote ( 645) 750 81.0 1.1e-14 NP_665917 (OMIM: 609779) serine/threonine-protein ( 470) 742 80.0 1.6e-14 NP_001308152 (OMIM: 609779) serine/threonine-prote ( 482) 742 80.1 1.6e-14 XP_016862705 (OMIM: 609779) PREDICTED: serine/thre ( 563) 732 79.3 3.2e-14 XP_016862704 (OMIM: 609779) PREDICTED: serine/thre ( 563) 732 79.3 3.2e-14 XP_016862701 (OMIM: 609779) PREDICTED: serine/thre ( 609) 732 79.4 3.3e-14 NP_149107 (OMIM: 609798,614262,617022,617025) seri ( 979) 668 74.1 2e-12 NP_001316166 (OMIM: 609798,614262,617022,617025) s ( 991) 668 74.1 2e-12 NP_835464 (OMIM: 609799,613824,615415) serine/thre ( 692) 631 70.7 1.5e-11 XP_016879988 (OMIM: 609799,613824,615415) PREDICTE ( 705) 631 70.7 1.6e-11 NP_001159640 (OMIM: 604884) serine/threonine-prote ( 313) 609 68.2 3.9e-11 NP_001159642 (OMIM: 604884) serine/threonine-prote ( 313) 609 68.2 3.9e-11 XP_006716999 (OMIM: 604884) PREDICTED: serine/thre ( 313) 609 68.2 3.9e-11 NP_055212 (OMIM: 604884) serine/threonine-protein ( 313) 609 68.2 3.9e-11 XP_005251721 (OMIM: 604884) PREDICTED: serine/thre ( 313) 609 68.2 3.9e-11 NP_001159639 (OMIM: 604884) serine/threonine-prote ( 331) 609 68.2 4.1e-11 NP_001159641 (OMIM: 604884) serine/threonine-prote ( 338) 609 68.2 4.1e-11 NP_001159643 (OMIM: 604884) serine/threonine-prote ( 347) 609 68.2 4.2e-11 XP_016869706 (OMIM: 604884) PREDICTED: serine/thre ( 347) 609 68.2 4.2e-11 NP_001138473 (OMIM: 604884) serine/threonine-prote ( 347) 609 68.2 4.2e-11 >>NP_001139571 (OMIM: 604044) serine/threonine-protein k (489 aa) initn: 3291 init1: 3291 opt: 3291 Z-score: 1580.3 bits: 301.9 E(85289): 2.8e-81 Smith-Waterman score: 3291; 100.0% identity (100.0% similar) in 489 aa overlap (1-489:1-489) 10 20 30 40 50 60 pF1KE0 MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 KRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 NKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 NPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKKQEEEQDRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKKQEEEQDRK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 GSHTDLESINENLVESALRRVNREEKGNKSVHLRKASSPNLHRRQWEKNVPNTALTALEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSHTDLESINENLVESALRRVNREEKGNKSVHLRKASSPNLHRRQWEKNVPNTALTALEN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 ASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILKNADLSLAFQTYTIYRPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILKNADLSLAFQTYTIYRPG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 SEGFLKGPLSEETEASDSVDGGHDSVILDPERLEPGLDEEDTDFEEEDDNPDWVSELKKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SEGFLKGPLSEETEASDSVDGGHDSVILDPERLEPGLDEEDTDFEEEDDNPDWVSELKKR 430 440 450 460 470 480 pF1KE0 AGWQGLCDR ::::::::: NP_001 AGWQGLCDR >>NP_689933 (OMIM: 604044) serine/threonine-protein kina (506 aa) initn: 3277 init1: 1994 opt: 2005 Z-score: 975.4 bits: 190.0 E(85289): 1.4e-47 Smith-Waterman score: 3247; 96.6% identity (96.6% similar) in 506 aa overlap (1-489:1-506) 10 20 30 40 50 60 pF1KE0 MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 KRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 KRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 NKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 NKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKR 190 200 210 220 230 240 250 260 270 280 290 pF1KE0 NPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKK-------- :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 NPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKKTNPSRIRI 250 260 270 280 290 300 300 310 320 330 340 pF1KE0 ---------QEEEQDRKGSHTDLESINENLVESALRRVNREEKGNKSVHLRKASSPNLHR ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 ALGNEASTVQEEEQDRKGSHTDLESINENLVESALRRVNREEKGNKSVHLRKASSPNLHR 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE0 RQWEKNVPNTALTALENASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 RQWEKNVPNTALTALENASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILK 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE0 NADLSLAFQTYTIYRPGSEGFLKGPLSEETEASDSVDGGHDSVILDPERLEPGLDEEDTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 NADLSLAFQTYTIYRPGSEGFLKGPLSEETEASDSVDGGHDSVILDPERLEPGLDEEDTD 430 440 450 460 470 480 470 480 pF1KE0 FEEEDDNPDWVSELKKRAGWQGLCDR :::::::::::::::::::::::::: NP_689 FEEEDDNPDWVSELKKRAGWQGLCDR 490 500 >>NP_002489 (OMIM: 604044) serine/threonine-protein kina (506 aa) initn: 3277 init1: 1994 opt: 2005 Z-score: 975.4 bits: 190.0 E(85289): 1.4e-47 Smith-Waterman score: 3247; 96.6% identity (96.6% similar) in 506 aa overlap (1-489:1-506) 10 20 30 40 50 60 pF1KE0 MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 KRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 KRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 NKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 NKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKR 190 200 210 220 230 240 250 260 270 280 290 pF1KE0 NPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKK-------- :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 NPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKKTNPSRIRI 250 260 270 280 290 300 300 310 320 330 340 pF1KE0 ---------QEEEQDRKGSHTDLESINENLVESALRRVNREEKGNKSVHLRKASSPNLHR ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ALGNEASTVQEEEQDRKGSHTDLESINENLVESALRRVNREEKGNKSVHLRKASSPNLHR 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE0 RQWEKNVPNTALTALENASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 RQWEKNVPNTALTALENASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILK 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE0 NADLSLAFQTYTIYRPGSEGFLKGPLSEETEASDSVDGGHDSVILDPERLEPGLDEEDTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 NADLSLAFQTYTIYRPGSEGFLKGPLSEETEASDSVDGGHDSVILDPERLEPGLDEEDTD 430 440 450 460 470 480 470 480 pF1KE0 FEEEDDNPDWVSELKKRAGWQGLCDR :::::::::::::::::::::::::: NP_002 FEEEDDNPDWVSELKKRAGWQGLCDR 490 500 >>XP_011530307 (OMIM: 263520,604588) PREDICTED: serine/t (715 aa) initn: 1104 init1: 988 opt: 1094 Z-score: 545.7 bits: 111.0 E(85289): 1.2e-23 Smith-Waterman score: 1094; 46.8% identity (77.5% similar) in 355 aa overlap (1-353:1-351) 10 20 30 40 50 pF1KE0 MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKH :. :. :. :::::::.:.::. .......::: . . : .. ..::.:...::.::: XP_011 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH :::: ..:::: .: :::::.::.::::...:. ::: :: ::.::.::.:.::...:.: XP_011 PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 KKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPY ...:::::::.:::::..: :.::::: ::.:.. . .: : .:::::. ::: :: :: XP_011 DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPY 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE0 NNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFK :::::::.:::.::::::::: :.:.: :::.::. .: . :. ::::.:. ::.:.:: XP_011 NNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFK 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE0 RNPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEI-KNSKHNTPRKKQEEEQD ::: :::....: .:..:. ..: : :..: : : :. . : ... : :. :. XP_011 RNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAE--EFCLKTFSKFGSQPIPAKRPASGQN 250 260 270 280 290 300 310 320 330 340 350 pF1KE0 RKGSHTDLESINENLVESALRRVNREEKGNKSVHLRKASSPNLHRRQWEKNVPNTALTAL . : ..:.. .. .. . .. :.:..: .: . . . .: .. :: XP_011 -SISVMPAQKITKPAAKYGIP-LAYKKYGDKKLHEKKPLQKHKQAHQTPEKRVNTGEERR 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE0 ENASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILKNADLSLAFQTYTIYR XP_011 KISEEAARKRRLEFIEKEKKQKDQIISLMKAEQMKRQEKERLERINRAREQGWRNVLSAG 360 370 380 390 400 410 >>NP_001186328 (OMIM: 263520,604588) serine/threonine-pr (1189 aa) initn: 1106 init1: 988 opt: 1094 Z-score: 543.8 bits: 111.3 E(85289): 1.5e-23 Smith-Waterman score: 1094; 46.8% identity (77.5% similar) in 355 aa overlap (1-353:1-351) 10 20 30 40 50 pF1KE0 MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKH :. :. :. :::::::.:.::. .......::: . . : .. ..::.:...::.::: NP_001 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH :::: ..:::: .: :::::.::.::::...:. ::: :: ::.::.::.:.::...:.: NP_001 PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 KKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPY ...:::::::.:::::..: :.::::: ::.:.. . .: : .:::::. ::: :: :: NP_001 DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPY 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE0 NNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFK :::::::.:::.::::::::: :.:.: :::.::. .: . :. ::::.:. ::.:.:: NP_001 NNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFK 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE0 RNPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEI-KNSKHNTPRKKQEEEQD ::: :::....: .:..:. ..: : :..: : : :. . : ... : :. :. NP_001 RNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAE--EFCLKTFSKFGSQPIPAKRPASGQN 250 260 270 280 290 300 310 320 330 340 350 pF1KE0 RKGSHTDLESINENLVESALRRVNREEKGNKSVHLRKASSPNLHRRQWEKNVPNTALTAL . : ..:.. .. .. . .. :.:..: .: . . . .: .. :: NP_001 -SISVMPAQKITKPAAKYGIP-LAYKKYGDKKLHEKKPLQKHKQAHQTPEKRVNTGEERR 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE0 ENASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILKNADLSLAFQTYTIYR NP_001 KISEEAARKRRLEFIEKEKKQKDQIISLMKAEQMKRQEKERAPFLGSGGTIAPSSFSSRG 360 370 380 390 400 410 >>XP_011530306 (OMIM: 263520,604588) PREDICTED: serine/t (1214 aa) initn: 1106 init1: 988 opt: 1094 Z-score: 543.7 bits: 111.4 E(85289): 1.5e-23 Smith-Waterman score: 1094; 46.8% identity (77.5% similar) in 355 aa overlap (1-353:1-351) 10 20 30 40 50 pF1KE0 MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKH :. :. :. :::::::.:.::. .......::: . . : .. ..::.:...::.::: XP_011 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH :::: ..:::: .: :::::.::.::::...:. ::: :: ::.::.::.:.::...:.: XP_011 PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 KKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPY ...:::::::.:::::..: :.::::: ::.:.. . .: : .:::::. ::: :: :: XP_011 DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPY 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE0 NNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFK :::::::.:::.::::::::: :.:.: :::.::. .: . :. ::::.:. ::.:.:: XP_011 NNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFK 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE0 RNPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEI-KNSKHNTPRKKQEEEQD ::: :::....: .:..:. ..: : :..: : : :. . : ... : :. :. XP_011 RNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAE--EFCLKTFSKFGSQPIPAKRPASGQN 250 260 270 280 290 300 310 320 330 340 350 pF1KE0 RKGSHTDLESINENLVESALRRVNREEKGNKSVHLRKASSPNLHRRQWEKNVPNTALTAL . : ..:.. .. .. . .. :.:..: .: . . . .: .. :: XP_011 -SISVMPAQKITKPAAKYGIP-LAYKKYGDKKLHEKKPLQKHKQAHQTPEKRVNTGEERR 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE0 ENASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILKNADLSLAFQTYTIYR XP_011 KISEEAARKRRLEFIEKEKKQKDQIISLMKAEQMKRQEKERLERINRAREQGWRNVLSAG 360 370 380 390 400 410 >>NP_001186329 (OMIM: 263520,604588) serine/threonine-pr (1214 aa) initn: 1106 init1: 988 opt: 1094 Z-score: 543.7 bits: 111.4 E(85289): 1.5e-23 Smith-Waterman score: 1094; 46.8% identity (77.5% similar) in 355 aa overlap (1-353:1-351) 10 20 30 40 50 pF1KE0 MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKH :. :. :. :::::::.:.::. .......::: . . : .. ..::.:...::.::: NP_001 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH :::: ..:::: .: :::::.::.::::...:. ::: :: ::.::.::.:.::...:.: NP_001 PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 KKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPY ...:::::::.:::::..: :.::::: ::.:.. . .: : .:::::. ::: :: :: NP_001 DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPY 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE0 NNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFK :::::::.:::.::::::::: :.:.: :::.::. .: . :. ::::.:. ::.:.:: NP_001 NNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFK 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE0 RNPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEI-KNSKHNTPRKKQEEEQD ::: :::....: .:..:. ..: : :..: : : :. . : ... : :. :. NP_001 RNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAE--EFCLKTFSKFGSQPIPAKRPASGQN 250 260 270 280 290 300 310 320 330 340 350 pF1KE0 RKGSHTDLESINENLVESALRRVNREEKGNKSVHLRKASSPNLHRRQWEKNVPNTALTAL . : ..:.. .. .. . .. :.:..: .: . . . .: .. :: NP_001 -SISVMPAQKITKPAAKYGIP-LAYKKYGDKKLHEKKPLQKHKQAHQTPEKRVNTGEERR 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE0 ENASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILKNADLSLAFQTYTIYR NP_001 KISEEAARKRRLEFIEKEKKQKDQIISLMKAEQMKRQEKERLERINRAREQGWRNVLSAG 360 370 380 390 400 410 >>XP_006714291 (OMIM: 263520,604588) PREDICTED: serine/t (1227 aa) initn: 1142 init1: 988 opt: 1094 Z-score: 543.7 bits: 111.4 E(85289): 1.5e-23 Smith-Waterman score: 1094; 46.8% identity (77.5% similar) in 355 aa overlap (1-353:1-351) 10 20 30 40 50 pF1KE0 MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKH :. :. :. :::::::.:.::. .......::: . . : .. ..::.:...::.::: XP_006 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH :::: ..:::: .: :::::.::.::::...:. ::: :: ::.::.::.:.::...:.: XP_006 PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 KKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPY ...:::::::.:::::..: :.::::: ::.:.. . .: : .:::::. ::: :: :: XP_006 DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPY 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE0 NNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFK :::::::.:::.::::::::: :.:.: :::.::. .: . :. ::::.:. ::.:.:: XP_006 NNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFK 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE0 RNPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEI-KNSKHNTPRKKQEEEQD ::: :::....: .:..:. ..: : :..: : : :. . : ... : :. :. XP_006 RNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAE--EFCLKTFSKFGSQPIPAKRPASGQN 250 260 270 280 290 300 310 320 330 340 350 pF1KE0 RKGSHTDLESINENLVESALRRVNREEKGNKSVHLRKASSPNLHRRQWEKNVPNTALTAL . : ..:.. .. .. . .. :.:..: .: . . . .: .. :: XP_006 -SISVMPAQKITKPAAKYGIP-LAYKKYGDKKLHEKKPLQKHKQAHQTPEKRVNTGEERR 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE0 ENASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILKNADLSLAFQTYTIYR XP_006 KISEEAARKRRLEFIEKEKKQKDQIISLMKAEQMKRQEKERLERINRAREQGWRNVLSAG 360 370 380 390 400 410 >>NP_001186327 (OMIM: 263520,604588) serine/threonine-pr (1242 aa) initn: 1142 init1: 988 opt: 1094 Z-score: 543.6 bits: 111.4 E(85289): 1.5e-23 Smith-Waterman score: 1094; 46.8% identity (77.5% similar) in 355 aa overlap (1-353:1-351) 10 20 30 40 50 pF1KE0 MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKH :. :. :. :::::::.:.::. .......::: . . : .. ..::.:...::.::: NP_001 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH :::: ..:::: .: :::::.::.::::...:. ::: :: ::.::.::.:.::...:.: NP_001 PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 KKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPY ...:::::::.:::::..: :.::::: ::.:.. . .: : .:::::. ::: :: :: NP_001 DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPY 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE0 NNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFK :::::::.:::.::::::::: :.:.: :::.::. .: . :. ::::.:. ::.:.:: NP_001 NNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFK 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE0 RNPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEI-KNSKHNTPRKKQEEEQD ::: :::....: .:..:. ..: : :..: : : :. . : ... : :. :. NP_001 RNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAE--EFCLKTFSKFGSQPIPAKRPASGQN 250 260 270 280 290 300 310 320 330 340 350 pF1KE0 RKGSHTDLESINENLVESALRRVNREEKGNKSVHLRKASSPNLHRRQWEKNVPNTALTAL . : ..:.. .. .. . .. :.:..: .: . . . .: .. :: NP_001 -SISVMPAQKITKPAAKYGIP-LAYKKYGDKKLHEKKPLQKHKQAHQTPEKRVNTGEERR 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE0 ENASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILKNADLSLAFQTYTIYR NP_001 KISEEAARKRRLEFIEKEKKQKDQIISLMKAEQMKRQEKERLERINRAREQGWRNVLSAG 360 370 380 390 400 410 >>NP_036356 (OMIM: 263520,604588) serine/threonine-prote (1258 aa) initn: 1106 init1: 988 opt: 1094 Z-score: 543.6 bits: 111.4 E(85289): 1.5e-23 Smith-Waterman score: 1094; 46.8% identity (77.5% similar) in 355 aa overlap (1-353:1-351) 10 20 30 40 50 pF1KE0 MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKH :. :. :. :::::::.:.::. .......::: . . : .. ..::.:...::.::: NP_036 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH :::: ..:::: .: :::::.::.::::...:. ::: :: ::.::.::.:.::...:.: NP_036 PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 KKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPY ...:::::::.:::::..: :.::::: ::.:.. . .: : .:::::. ::: :: :: NP_036 DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPY 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE0 NNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFK :::::::.:::.::::::::: :.:.: :::.::. .: . :. ::::.:. ::.:.:: NP_036 NNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFK 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE0 RNPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEI-KNSKHNTPRKKQEEEQD ::: :::....: .:..:. ..: : :..: : : :. . : ... : :. :. NP_036 RNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAE--EFCLKTFSKFGSQPIPAKRPASGQN 250 260 270 280 290 300 310 320 330 340 350 pF1KE0 RKGSHTDLESINENLVESALRRVNREEKGNKSVHLRKASSPNLHRRQWEKNVPNTALTAL . : ..:.. .. .. . .. :.:..: .: . . . .: .. :: NP_036 -SISVMPAQKITKPAAKYGIP-LAYKKYGDKKLHEKKPLQKHKQAHQTPEKRVNTGEERR 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE0 ENASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILKNADLSLAFQTYTIYR NP_036 KISEEAARKRRLEFIEKEKKQKDQIISLMKAEQMKRQEKERLERINRAREQGWRNVLSAG 360 370 380 390 400 410 489 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 04:44:27 2016 done: Sat Nov 5 04:44:29 2016 Total Scan time: 10.080 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]