Result of FASTA (omim) for
pF1KE0967
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0967, 513 aa
1>>>pF1KE0967 513 - 513 aa - 513 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.5610+/-0.00049; mu= 0.8685+/- 0.030
mean_var=670.2472+/-158.397, 0's: 0 Z-trim(119.7): 193 B-trim: 0 in 0/57
Lambda= 0.049540
statistics sampled from 33872 (34073) to 33872 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.715), E-opt: 0.2 (0.4), width: 16
Scan time: 9.890
The best scores are: opt bits E(85289)
NP_001265508 (OMIM: 102581) activin receptor type- ( 513) 3558 270.1 1.1e-71
NP_001607 (OMIM: 102581) activin receptor type-2A ( 513) 3558 270.1 1.1e-71
NP_001265509 (OMIM: 102581) activin receptor type- ( 405) 2772 213.8 7.9e-55
NP_001097 (OMIM: 602730,613751) activin receptor t ( 512) 2533 196.9 1.2e-49
XP_016863003 (OMIM: 602730,613751) PREDICTED: acti ( 526) 2522 196.1 2.1e-49
XP_016863005 (OMIM: 602730,613751) PREDICTED: acti ( 511) 2521 196.0 2.2e-49
XP_016863004 (OMIM: 602730,613751) PREDICTED: acti ( 518) 2521 196.0 2.2e-49
XP_005265640 (OMIM: 602730,613751) PREDICTED: acti ( 533) 2521 196.0 2.3e-49
XP_011532347 (OMIM: 133239,190182,610168,614331) P ( 532) 935 82.7 3e-15
XP_016862595 (OMIM: 133239,190182,610168,614331) P ( 532) 935 82.7 3e-15
NP_003233 (OMIM: 133239,190182,610168,614331) TGF- ( 567) 935 82.7 3.1e-15
XP_011532345 (OMIM: 133239,190182,610168,614331) P ( 576) 935 82.7 3.1e-15
NP_001020018 (OMIM: 133239,190182,610168,614331) T ( 592) 935 82.8 3.1e-15
XP_011517252 (OMIM: 132800,190181) PREDICTED: TGF- ( 357) 801 72.8 1.9e-12
NP_001124388 (OMIM: 132800,190181) TGF-beta recept ( 426) 801 72.9 2.1e-12
XP_011517251 (OMIM: 132800,190181) PREDICTED: TGF- ( 434) 800 72.9 2.2e-12
XP_011517250 (OMIM: 132800,190181) PREDICTED: TGF- ( 438) 800 72.9 2.2e-12
XP_016870552 (OMIM: 132800,190181) PREDICTED: TGF- ( 438) 800 72.9 2.2e-12
NP_004603 (OMIM: 132800,190181) TGF-beta receptor ( 503) 800 73.0 2.3e-12
NP_001293139 (OMIM: 132800,190181) TGF-beta recept ( 507) 800 73.0 2.3e-12
NP_001104502 (OMIM: 608981) activin receptor type- ( 413) 795 72.5 2.7e-12
NP_001104501 (OMIM: 608981) activin receptor type- ( 443) 793 72.4 3.1e-12
NP_660302 (OMIM: 608981) activin receptor type-1C ( 493) 793 72.5 3.3e-12
NP_004320 (OMIM: 174900,601299,610069) bone morpho ( 532) 789 72.3 4.1e-12
XP_011538405 (OMIM: 174900,601299,610069) PREDICTE ( 532) 789 72.3 4.1e-12
XP_011538406 (OMIM: 174900,601299,610069) PREDICTE ( 532) 789 72.3 4.1e-12
XP_016864048 (OMIM: 112600,603248,609441,616849) P ( 502) 780 71.6 6.3e-12
NP_001243723 (OMIM: 112600,603248,609441,616849) b ( 502) 780 71.6 6.3e-12
XP_011530503 (OMIM: 112600,603248,609441,616849) P ( 502) 780 71.6 6.3e-12
NP_001243721 (OMIM: 112600,603248,609441,616849) b ( 502) 780 71.6 6.3e-12
XP_016864047 (OMIM: 112600,603248,609441,616849) P ( 502) 780 71.6 6.3e-12
NP_001194 (OMIM: 112600,603248,609441,616849) bone ( 502) 780 71.6 6.3e-12
XP_016864050 (OMIM: 112600,603248,609441,616849) P ( 502) 780 71.6 6.3e-12
XP_016864049 (OMIM: 112600,603248,609441,616849) P ( 502) 780 71.6 6.3e-12
NP_001243722 (OMIM: 112600,603248,609441,616849) b ( 532) 780 71.6 6.5e-12
XP_011509989 (OMIM: 178600,265450,600799) PREDICTE (1037) 774 71.7 1.2e-11
NP_001195 (OMIM: 178600,265450,600799) bone morpho (1038) 774 71.7 1.2e-11
NP_064732 (OMIM: 601300) activin receptor type-1B ( 453) 763 70.3 1.4e-11
NP_004293 (OMIM: 601300) activin receptor type-1B ( 505) 763 70.4 1.5e-11
NP_001104537 (OMIM: 102576,135100) activin recepto ( 509) 740 68.7 4.6e-11
NP_001096 (OMIM: 102576,135100) activin receptor t ( 509) 740 68.7 4.6e-11
XP_005246997 (OMIM: 102576,135100) PREDICTED: acti ( 509) 740 68.7 4.6e-11
XP_011510410 (OMIM: 102576,135100) PREDICTED: acti ( 509) 740 68.7 4.6e-11
XP_006712888 (OMIM: 102576,135100) PREDICTED: acti ( 509) 740 68.7 4.6e-11
XP_005246996 (OMIM: 102576,135100) PREDICTED: acti ( 509) 740 68.7 4.6e-11
XP_011510408 (OMIM: 102576,135100) PREDICTED: acti ( 509) 740 68.7 4.6e-11
XP_011510409 (OMIM: 102576,135100) PREDICTED: acti ( 509) 740 68.7 4.6e-11
NP_000011 (OMIM: 600376,601284) serine/threonine-p ( 503) 707 66.4 2.3e-10
XP_005269292 (OMIM: 600376,601284) PREDICTED: seri ( 503) 707 66.4 2.3e-10
NP_001070869 (OMIM: 600376,601284) serine/threonin ( 503) 707 66.4 2.3e-10
>>NP_001265508 (OMIM: 102581) activin receptor type-2A i (513 aa)
initn: 3558 init1: 3558 opt: 3558 Z-score: 1408.1 bits: 270.1 E(85289): 1.1e-71
Smith-Waterman score: 3558; 100.0% identity (100.0% similar) in 513 aa overlap (1-513:1-513)
10 20 30 40 50 60
pF1KE0 MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGDKDKRRHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGDKDKRRHC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 FATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 EVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 PPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 MKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 AYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 GTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 QHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERIT
430 440 450 460 470 480
490 500 510
pF1KE0 QMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL
:::::::::::::::::::::::::::::::::
NP_001 QMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL
490 500 510
>>NP_001607 (OMIM: 102581) activin receptor type-2A isof (513 aa)
initn: 3558 init1: 3558 opt: 3558 Z-score: 1408.1 bits: 270.1 E(85289): 1.1e-71
Smith-Waterman score: 3558; 100.0% identity (100.0% similar) in 513 aa overlap (1-513:1-513)
10 20 30 40 50 60
pF1KE0 MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGDKDKRRHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGDKDKRRHC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 FATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 EVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 PPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 MKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 AYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 GTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 QHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERIT
430 440 450 460 470 480
490 500 510
pF1KE0 QMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL
:::::::::::::::::::::::::::::::::
NP_001 QMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL
490 500 510
>>NP_001265509 (OMIM: 102581) activin receptor type-2A i (405 aa)
initn: 2772 init1: 2772 opt: 2772 Z-score: 1105.4 bits: 213.8 E(85289): 7.9e-55
Smith-Waterman score: 2772; 100.0% identity (100.0% similar) in 405 aa overlap (109-513:1-405)
80 90 100 110 120 130
pF1KE0 WLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYN
::::::::::::::::::::::::::::::
NP_001 MCNEKFSYFPEMEVTQPTSNPVTPKPPYYN
10 20 30
140 150 160 170 180 190
pF1KE0 ILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGPPPPSPLLGLKPLQLLEVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGPPPPSPLLGLKPLQLLEVK
40 50 60 70 80 90
200 210 220 230 240 250
pF1KE0 ARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTS
100 110 120 130 140 150
260 270 280 290 300 310
pF1KE0 VDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAI
160 170 180 190 200 210
320 330 340 350 360 370
pF1KE0 SHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQ
220 230 240 250 260 270
380 390 400 410 420 430
pF1KE0 RDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKR
280 290 300 310 320 330
440 450 460 470 480 490
pF1KE0 PVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIVTVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIVTVV
340 350 360 370 380 390
500 510
pF1KE0 TMVTNVDFPPKESSL
:::::::::::::::
NP_001 TMVTNVDFPPKESSL
400
>>NP_001097 (OMIM: 602730,613751) activin receptor type- (512 aa)
initn: 2337 init1: 1547 opt: 2533 Z-score: 1012.2 bits: 196.9 E(85289): 1.2e-49
Smith-Waterman score: 2533; 67.3% identity (87.9% similar) in 511 aa overlap (4-513:3-512)
10 20 30 40 50 60
pF1KE0 MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGDKDKRRHC
: .:.:.. : .:. :..::.::...::::: .::::.:.: : :..::: ::
NP_001 MTAPWVALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHC
10 20 30 40 50
70 80 90 100 110 120
pF1KE0 FATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEM
.:.:.: ::.::.::.::::::.::::: .:: ...:.:::::::::.:::.:...::
NP_001 YASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEA
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE0 EVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGP
. : .: : ..: :::.:. .. ::. :::.:::.: : : . .::::
NP_001 GGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIH-EDPGP
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE0 PPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPG
::::::.:::::::::.::::::::::::::.:..:::::::.:::::::.: :..: ::
NP_001 PPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPG
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE0 MKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGL
:::::.::::.:::::....:.::::::::.::::.:.::.:...::::::.::::.:::
NP_001 MKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGL
240 250 260 270 280 290
310 320 330 340 350
pF1KE0 AYLHEDIPGLK-DGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQ
.:::::.: . .::::.:.:::.::::::::..::: .::::::..:: :: ::::::
NP_001 SYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQ
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE0 VGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEI
::::::::::::::::::::::::::::::::::::::.::: :::::::::::::::::
NP_001 VGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEI
360 370 380 390 400 410
420 430 440 450 460 470
pF1KE0 GQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERI
:::::::..:::::::: ::...:.: :: :.:.:: ::::::::::::::::::: ::.
NP_001 GQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERV
420 430 440 450 460 470
480 490 500 510
pF1KE0 TQMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL
. ..: .: :.. .:..:: :::::.::::::.
NP_001 SLIRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI
480 490 500 510
>>XP_016863003 (OMIM: 602730,613751) PREDICTED: activin (526 aa)
initn: 2337 init1: 1547 opt: 2522 Z-score: 1007.8 bits: 196.1 E(85289): 2.1e-49
Smith-Waterman score: 2522; 68.4% identity (88.7% similar) in 497 aa overlap (18-513:31-526)
10 20 30 40
pF1KE0 MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGV
.:. :..::.::...::::: .::::.:.
XP_016 MPLPLSGPAMWRSGEPQRLWAWSPQAGDTRAGSGRGEAETRECIYYNANWELERTNQSGL
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE0 EPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEG
: : :..::: ::.:.:.: ::.::.::.::::::.::::: .:: ...:.::::::::
XP_016 ERCEGEQDKRLHCYASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEG
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE0 NMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMA
:.:::.:...:: . : .: : ..: :::.:. .. ::. :::.:::.:
XP_016 NFCNERFTHLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPP
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE0 YPPVLVPTQDPGPPPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQ
: : . .::::::::::.:::::::::.::::::::::::::.:..:::::::.::::
XP_016 YGHVDIH-EDPGPPPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQ
190 200 210 220 230
230 240 250 260 270 280
pF1KE0 SWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWN
:::.: :..: :::::::.::::.:::::....:.::::::::.::::.:.::.:...::
XP_016 SWQSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWN
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE0 ELCHIAETMARGLAYLHEDIPGLK-DGHKPAISHRDIKSKNVLLKNNLTACIADFGLALK
::::.::::.:::.:::::.: . .::::.:.:::.::::::::..::: .::::::..
XP_016 ELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVR
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE0 FEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADG
:: :: ::::::::::::::::::::::::::::::::::::::::::::.::: ::::
XP_016 FEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADG
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE0 PVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDA
::::::::::::::::::::..:::::::: ::...:.: :: :.:.:: ::::::::::
XP_016 PVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDA
420 430 440 450 460 470
470 480 490 500 510
pF1KE0 EARLSAGCVGERITQMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL
::::::::: ::.. ..: .: :.. .:..:: :::::.::::::.
XP_016 EARLSAGCVEERVSLIRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI
480 490 500 510 520
>>XP_016863005 (OMIM: 602730,613751) PREDICTED: activin (511 aa)
initn: 2337 init1: 1547 opt: 2521 Z-score: 1007.6 bits: 196.0 E(85289): 2.2e-49
Smith-Waterman score: 2521; 68.5% identity (88.7% similar) in 496 aa overlap (19-513:17-511)
10 20 30 40 50 60
pF1KE0 MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGDKDKRRHC
:. :..::.::...::::: .::::.:.: : :..::: ::
XP_016 MMALLRSTNINNLSPVGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHC
10 20 30 40 50
70 80 90 100 110 120
pF1KE0 FATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEM
.:.:.: ::.::.::.::::::.::::: .:: ...:.:::::::::.:::.:...::
XP_016 YASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEA
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE0 EVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGP
. : .: : ..: :::.:. .. ::. :::.:::.: : : . .::::
XP_016 GGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIH-EDPGP
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE0 PPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPG
::::::.:::::::::.::::::::::::::.:..:::::::.:::::::.: :..: ::
XP_016 PPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPG
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE0 MKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGL
:::::.::::.:::::....:.::::::::.::::.:.::.:...::::::.::::.:::
XP_016 MKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGL
240 250 260 270 280 290
310 320 330 340 350
pF1KE0 AYLHEDIPGLK-DGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQ
.:::::.: . .::::.:.:::.::::::::..::: .::::::..:: :: ::::::
XP_016 SYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQ
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE0 VGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEI
::::::::::::::::::::::::::::::::::::::.::: :::::::::::::::::
XP_016 VGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEI
360 370 380 390 400 410
420 430 440 450 460 470
pF1KE0 GQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERI
:::::::..:::::::: ::...:.: :: :.:.:: ::::::::::::::::::: ::.
XP_016 GQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERV
420 430 440 450 460 470
480 490 500 510
pF1KE0 TQMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL
. ..: .: :.. .:..:: :::::.::::::.
XP_016 SLIRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI
480 490 500 510
>>XP_016863004 (OMIM: 602730,613751) PREDICTED: activin (518 aa)
initn: 2337 init1: 1547 opt: 2521 Z-score: 1007.5 bits: 196.0 E(85289): 2.2e-49
Smith-Waterman score: 2521; 68.7% identity (88.6% similar) in 498 aa overlap (17-513:24-518)
10 20 30 40 50
pF1KE0 MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGD
::: :..::.::...::::: .::::.:.: : :.
XP_016 MGAGTRSLRVGVRATRARGTQGKSSGR--GEAETRECIYYNANWELERTNQSGLERCEGE
10 20 30 40 50
60 70 80 90 100 110
pF1KE0 KDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEK
.::: ::.:.:.: ::.::.::.::::::.::::: .:: ...:.:::::::::.:::.
XP_016 QDKRLHCYASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNER
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE0 FSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLV
:...:: . : .: : ..: :::.:. .. ::. :::.:::.: : : .
XP_016 FTHLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDI
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE0 PTQDPGPPPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEY
.::::::::::.:::::::::.::::::::::::::.:..:::::::.:::::::.:
XP_016 H-EDPGPPPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSER
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE0 EVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIA
:..: :::::::.::::.:::::....:.::::::::.::::.:.::.:...::::::.:
XP_016 EIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVA
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE0 ETMARGLAYLHEDIPGLK-DGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKS
:::.:::.:::::.: . .::::.:.:::.::::::::..::: .::::::..:: ::
XP_016 ETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKP
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE0 AGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYM
::::::::::::::::::::::::::::::::::::::::::::.::: ::::::::::
XP_016 PGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYM
360 370 380 390 400 410
420 430 440 450 460 470
pF1KE0 LPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSA
::::::::::::::..:::::::: ::...:.: :: :.:.:: ::::::::::::::::
XP_016 LPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSA
420 430 440 450 460 470
480 490 500 510
pF1KE0 GCVGERITQMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL
::: ::.. ..: .: :.. .:..:: :::::.::::::.
XP_016 GCVEERVSLIRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI
480 490 500 510
>>XP_005265640 (OMIM: 602730,613751) PREDICTED: activin (533 aa)
initn: 2337 init1: 1547 opt: 2521 Z-score: 1007.4 bits: 196.0 E(85289): 2.3e-49
Smith-Waterman score: 2521; 68.5% identity (88.7% similar) in 496 aa overlap (19-513:39-533)
10 20 30 40
pF1KE0 MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVE
:. :..::.::...::::: .::::.:.:
XP_005 AMWRSGEPQRLWAWSPQAGDTRAGGQPLPKGSGRGEAETRECIYYNANWELERTNQSGLE
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE0 PCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGN
: :..::: ::.:.:.: ::.::.::.::::::.::::: .:: ...:.:::::::::
XP_005 RCEGEQDKRLHCYASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGN
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE0 MCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAY
.:::.:...:: . : .: : ..: :::.:. .. ::. :::.:::.: :
XP_005 FCNERFTHLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPY
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE0 PPVLVPTQDPGPPPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQS
: . .::::::::::.:::::::::.::::::::::::::.:..:::::::.:::::
XP_005 GHVDIH-EDPGPPPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQS
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE0 WQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNE
::.: :..: :::::::.::::.:::::....:.::::::::.::::.:.::.:...:::
XP_005 WQSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNE
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE0 LCHIAETMARGLAYLHEDIPGLK-DGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKF
:::.::::.:::.:::::.: . .::::.:.:::.::::::::..::: .::::::..:
XP_005 LCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRF
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE0 EAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGP
: :: ::::::::::::::::::::::::::::::::::::::::::::.::: :::::
XP_005 EPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGP
370 380 390 400 410 420
410 420 430 440 450 460
pF1KE0 VDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAE
:::::::::::::::::::..:::::::: ::...:.: :: :.:.:: :::::::::::
XP_005 VDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAE
430 440 450 460 470 480
470 480 490 500 510
pF1KE0 ARLSAGCVGERITQMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL
:::::::: ::.. ..: .: :.. .:..:: :::::.::::::.
XP_005 ARLSAGCVEERVSLIRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI
490 500 510 520 530
>>XP_011532347 (OMIM: 133239,190182,610168,614331) PREDI (532 aa)
initn: 893 init1: 352 opt: 935 Z-score: 394.8 bits: 82.7 E(85289): 3e-15
Smith-Waterman score: 975; 34.3% identity (62.2% similar) in 519 aa overlap (13-485:2-509)
10 20 30 40 50
pF1KE0 MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGDK--DKRR
... ..::. . : : : .. . .... . : . .: .
XP_011 MIVTDNNGAV---KFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQ
10 20 30 40
60 70 80 90 100
pF1KE0 H-CFATWKNISGSIEIVKQGCWLDDINCYD-------RTDCV--EKKDSPEVYF-CCCEG
. : :.:.. . .: . . : . .: :. ::: :..: : : .
XP_011 EVCVAVWRKNDENITL-ETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSS
50 60 70 80 90 100
110 120 130 140 150 160
pF1KE0 NMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHK--
. ::... . :.....: : ... ::.: . .: :: :. :: ..
XP_011 DECNDNIIFSEEYNTSNPDLLLVI-----FQVTGISLLPPLGVAISVIIIFYCYRVNRQQ
110 120 130 140 150 160
170 180 190 200
pF1KE0 --------------MAYPP-VLVPTQDPGPPPPSPLLG-------LKPLQLLEVKARGRF
: . . .: : . : :..: . ..:::
XP_011 KLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRF
170 180 190 200 210 220
210 220 230 240 250
pF1KE0 GCVWKAQLLN------EYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGT
. :.::.: . : ::::::: .. ::..: ...: ..::::::::. ::.: :
XP_011 AEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKT
230 240 250 260 270 280
260 270 280 290 300 310
pF1KE0 SVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPA
. . ::::::: ::.:...: .:.::..: ... ..:::.:.:: : . :
XP_011 ELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMP-
290 300 310 320 330
320 330 340 350 360 370
pF1KE0 ISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMAPEVLEGAI
: :::.::.:.:.::.:: :. ::::.:... :. : . ::::: :::::::::. .
XP_011 IVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRM
340 350 360 370 380 390
380 390 400 410 420 430
pF1KE0 NFQR-DAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVH
:.. ..: . :.:.:.:::::..:::.:. : : .: :: .. .:: .:.:.. :..
XP_011 NLENVESFKQTDVYSMALVLWEMTSRCNAV-GEVKDYEPPFGSKVREHPCVESMKDNVLR
400 410 420 430 440 450
440 450 460 470 480 490
pF1KE0 KKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDI
. :: . ..: .: :. :.:::. :::::: ::::.: ::.::......:
XP_011 DRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLDRLSGRSCS
460 470 480 490 500 510
500 510
pF1KE0 VTVVTMVTNVDFPPKESSL
XP_011 EEKIPEDGSLNTTK
520 530
>>XP_016862595 (OMIM: 133239,190182,610168,614331) PREDI (532 aa)
initn: 893 init1: 352 opt: 935 Z-score: 394.8 bits: 82.7 E(85289): 3e-15
Smith-Waterman score: 975; 34.3% identity (62.2% similar) in 519 aa overlap (13-485:2-509)
10 20 30 40 50
pF1KE0 MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGDK--DKRR
... ..::. . : : : .. . .... . : . .: .
XP_016 MIVTDNNGAV---KFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQ
10 20 30 40
60 70 80 90 100
pF1KE0 H-CFATWKNISGSIEIVKQGCWLDDINCYD-------RTDCV--EKKDSPEVYF-CCCEG
. : :.:.. . .: . . : . .: :. ::: :..: : : .
XP_016 EVCVAVWRKNDENITL-ETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSS
50 60 70 80 90 100
110 120 130 140 150 160
pF1KE0 NMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHK--
. ::... . :.....: : ... ::.: . .: :: :. :: ..
XP_016 DECNDNIIFSEEYNTSNPDLLLVI-----FQVTGISLLPPLGVAISVIIIFYCYRVNRQQ
110 120 130 140 150 160
170 180 190 200
pF1KE0 --------------MAYPP-VLVPTQDPGPPPPSPLLG-------LKPLQLLEVKARGRF
: . . .: : . : :..: . ..:::
XP_016 KLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRF
170 180 190 200 210 220
210 220 230 240 250
pF1KE0 GCVWKAQLLN------EYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGT
. :.::.: . : ::::::: .. ::..: ...: ..::::::::. ::.: :
XP_016 AEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKT
230 240 250 260 270 280
260 270 280 290 300 310
pF1KE0 SVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPA
. . ::::::: ::.:...: .:.::..: ... ..:::.:.:: : . :
XP_016 ELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMP-
290 300 310 320 330
320 330 340 350 360 370
pF1KE0 ISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMAPEVLEGAI
: :::.::.:.:.::.:: :. ::::.:... :. : . ::::: :::::::::. .
XP_016 IVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRM
340 350 360 370 380 390
380 390 400 410 420 430
pF1KE0 NFQR-DAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVH
:.. ..: . :.:.:.:::::..:::.:. : : .: :: .. .:: .:.:.. :..
XP_016 NLENVESFKQTDVYSMALVLWEMTSRCNAV-GEVKDYEPPFGSKVREHPCVESMKDNVLR
400 410 420 430 440 450
440 450 460 470 480 490
pF1KE0 KKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDI
. :: . ..: .: :. :.:::. :::::: ::::.: ::.::......:
XP_016 DRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLDRLSGRSCS
460 470 480 490 500 510
500 510
pF1KE0 VTVVTMVTNVDFPPKESSL
XP_016 EEKIPEDGSLNTTK
520 530
513 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 04:45:05 2016 done: Sat Nov 5 04:45:06 2016
Total Scan time: 9.890 Total Display time: 0.100
Function used was FASTA [36.3.4 Apr, 2011]