FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0970, 523 aa 1>>>pF1KE0970 523 - 523 aa - 523 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.7304+/-0.00109; mu= 15.9033+/- 0.065 mean_var=71.5995+/-14.446, 0's: 0 Z-trim(103.2): 50 B-trim: 4 in 1/48 Lambda= 0.151572 statistics sampled from 7262 (7291) to 7262 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.583), E-opt: 0.2 (0.224), width: 16 Scan time: 3.170 The best scores are: opt bits E(32554) CCDS9869.1 ADCK1 gene_id:57143|Hs108|chr14 ( 523) 3472 769.0 0 CCDS45144.1 ADCK1 gene_id:57143|Hs108|chr14 ( 455) 2566 570.8 1.1e-162 CCDS34965.2 ADCK5 gene_id:203054|Hs108|chr8 ( 580) 1038 236.7 5.4e-62 CCDS1557.1 COQ8A gene_id:56997|Hs108|chr1 ( 647) 362 88.9 1.9e-17 CCDS12562.1 COQ8B gene_id:79934|Hs108|chr19 ( 544) 353 86.9 6.3e-17 CCDS46081.1 COQ8B gene_id:79934|Hs108|chr19 ( 503) 282 71.4 2.8e-12 >>CCDS9869.1 ADCK1 gene_id:57143|Hs108|chr14 (523 aa) initn: 3472 init1: 3472 opt: 3472 Z-score: 4103.7 bits: 769.0 E(32554): 0 Smith-Waterman score: 3472; 100.0% identity (100.0% similar) in 523 aa overlap (1-523:1-523) 10 20 30 40 50 60 pF1KE0 MARKALKLASWTSMALAASGIYFYSNKYLDPNDFGAVRVGRAVATTAVISYDYLTSLKSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS98 MARKALKLASWTSMALAASGIYFYSNKYLDPNDFGAVRVGRAVATTAVISYDYLTSLKSV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 PYGSEEYLQLRSKVHLRSARRLCELCCANRGTFIKVGQHLGALDYLLPEEYTSTLKVLHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS98 PYGSEEYLQLRSKVHLRSARRLCELCCANRGTFIKVGQHLGALDYLLPEEYTSTLKVLHS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 QAPQSSMQEIRQVIREDLGKEIHDLFQSFDDTPLGTASLAQVHKAVLHDGRTVAVKVQHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS98 QAPQSSMQEIRQVIREDLGKEIHDLFQSFDDTPLGTASLAQVHKAVLHDGRTVAVKVQHP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 KVRAQSSKDILLMEVLVLAVKQLFPEFEFMWLVDEAKKNLPLELDFLNEGRNAEKVSQML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS98 KVRAQSSKDILLMEVLVLAVKQLFPEFEFMWLVDEAKKNLPLELDFLNEGRNAEKVSQML 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 RHFDFLKVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS98 RHFDFLKVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 VNGFVHCDPHPGNVLVRKHPGTGKAEIVLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS98 VNGFVHCDPHPGNVLVRKHPGTGKAEIVLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 VKEYSQRLGAGDLYPLFACMLTARSWDSVNRGISQAPVTATEDLEIRNNAANYLPQISHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS98 VKEYSQRLGAGDLYPLFACMLTARSWDSVNRGISQAPVTATEDLEIRNNAANYLPQISHL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 LNHVPRQMLLILKTNDLLRGIEAALGTRASASSFLNMSRCCIRALAEHKKKNTCSFFRRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS98 LNHVPRQMLLILKTNDLLRGIEAALGTRASASSFLNMSRCCIRALAEHKKKNTCSFFRRT 430 440 450 460 470 480 490 500 510 520 pF1KE0 QISFSEAFNLWQINLHELILRVKGLKLADRVLALICWLFPAPL ::::::::::::::::::::::::::::::::::::::::::: CCDS98 QISFSEAFNLWQINLHELILRVKGLKLADRVLALICWLFPAPL 490 500 510 520 >>CCDS45144.1 ADCK1 gene_id:57143|Hs108|chr14 (455 aa) initn: 2566 init1: 2566 opt: 2566 Z-score: 3033.9 bits: 570.8 E(32554): 1.1e-162 Smith-Waterman score: 2875; 87.0% identity (87.0% similar) in 523 aa overlap (1-523:1-455) 10 20 30 40 50 60 pF1KE0 MARKALKLASWTSMALAASGIYFYSNKYLDPNDFGAVRVGRAVATTAVISYDYLTSLKSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 MARKALKLASWTSMALAASGIYFYSNKYLDPNDFGAVRVGRAVATTAVISYDYLTSLKSV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 PYGSEEYLQLRSKVHLRSARRLCELCCANRGTFIKVGQHLGALDYLLPEEYTSTLKVLHS ::::::::::::: CCDS45 PYGSEEYLQLRSK----------------------------------------------- 70 130 140 150 160 170 180 pF1KE0 QAPQSSMQEIRQVIREDLGKEIHDLFQSFDDTPLGTASLAQVHKAVLHDGRTVAVKVQHP ::::::::::::::::::::::::::::::::::::::: CCDS45 ---------------------IHDLFQSFDDTPLGTASLAQVHKAVLHDGRTVAVKVQHP 80 90 100 110 190 200 210 220 230 240 pF1KE0 KVRAQSSKDILLMEVLVLAVKQLFPEFEFMWLVDEAKKNLPLELDFLNEGRNAEKVSQML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 KVRAQSSKDILLMEVLVLAVKQLFPEFEFMWLVDEAKKNLPLELDFLNEGRNAEKVSQML 120 130 140 150 160 170 250 260 270 280 290 300 pF1KE0 RHFDFLKVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 RHFDFLKVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIF 180 190 200 210 220 230 310 320 330 340 350 360 pF1KE0 VNGFVHCDPHPGNVLVRKHPGTGKAEIVLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 VNGFVHCDPHPGNVLVRKHPGTGKAEIVLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKR 240 250 260 270 280 290 370 380 390 400 410 420 pF1KE0 VKEYSQRLGAGDLYPLFACMLTARSWDSVNRGISQAPVTATEDLEIRNNAANYLPQISHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 VKEYSQRLGAGDLYPLFACMLTARSWDSVNRGISQAPVTATEDLEIRNNAANYLPQISHL 300 310 320 330 340 350 430 440 450 460 470 480 pF1KE0 LNHVPRQMLLILKTNDLLRGIEAALGTRASASSFLNMSRCCIRALAEHKKKNTCSFFRRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 LNHVPRQMLLILKTNDLLRGIEAALGTRASASSFLNMSRCCIRALAEHKKKNTCSFFRRT 360 370 380 390 400 410 490 500 510 520 pF1KE0 QISFSEAFNLWQINLHELILRVKGLKLADRVLALICWLFPAPL ::::::::::::::::::::::::::::::::::::::::::: CCDS45 QISFSEAFNLWQINLHELILRVKGLKLADRVLALICWLFPAPL 420 430 440 450 >>CCDS34965.2 ADCK5 gene_id:203054|Hs108|chr8 (580 aa) initn: 952 init1: 704 opt: 1038 Z-score: 1226.5 bits: 236.7 E(32554): 5.4e-62 Smith-Waterman score: 1043; 38.4% identity (65.1% similar) in 490 aa overlap (35-515:83-558) 10 20 30 40 50 60 pF1KE0 ALKLASWTSMALAASGIYFYSNKYLDPNDFGAVRVGRAVATTAVISYDYLTSLKSVPYGS : : ::.. . :: :: . : : CCDS34 TAVVGAPLLLGARYVMAEAREKRRMRLVVDGMGRFGRSLKVGLQISLDYWWCTNVVLRGV 60 70 80 90 100 110 70 80 90 100 110 120 pF1KE0 EE----YLQLRSKVHLRSARRLCELCCANRGTFIKVGQHLGALDYLLPEEYTSTLKVLHS :: ::.. : : :.: : .: : ..:.:: : ....::: ::: ::.::.. CCDS34 EENSPGYLEVMSACHQRAADALVAGAISNGGLYVKLGQGLCSFNHLLPPEYTRTLRVLED 120 130 140 150 160 170 130 140 150 160 170 180 pF1KE0 QAPQSSMQEIRQVIREDLGKEIHDLFQSFDDTPLGTASLAQVHKAVLHDGRTVAVKVQHP .: . ..::. ... ::. :.::: :: :...:::::::.: :::: .::::::. CCDS34 RALKRGFQEVDELFLEDFQALPHELFQEFDYQPIAAASLAQVHRAKLHDGTSVAVKVQYI 180 190 200 210 220 230 190 200 210 220 230 240 pF1KE0 KVRAQSSKDILLMEVLVLAVKQLFPEFEFMWLVDEAKKNLPLELDFLNEGRNAEKVSQML .: . . :: .:.:. :. . : : : :.... : .: :::: :::::::. .. : CCDS34 DLRDRFDGDIHTLELLLRLVEVMHPSFGFSWVLQDLKGTLAQELDFENEGRNAERCAREL 240 250 260 270 280 290 250 260 270 280 290 300 pF1KE0 RHFDFLKVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIF :: .. :::.::: :..::: .: : .::: . .. . . :..:...: : ..:.:: CCDS34 AHFPYVVVPRVHWDKSSKRVLTADFCAGCKVNDVEAIRSQGLAVHDIAEKLIKAFAEQIF 300 310 320 330 340 350 310 320 330 340 350 360 pF1KE0 VNGFVHCDPHPGNVLVRKHPGTGKAEIVLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKR .::.: ::::::::::: : ::::.:::::::::.: :. : :.::...: : CCDS34 YTGFIHSDPHPGNVLVRKGPD-GKAELVLLDHGLYQFLEEKDRAALCQLWRAIILRDDAA 360 370 380 390 400 410 370 380 390 400 410 420 pF1KE0 VKEYSQRLGAGDLYPLFACMLTARSWDSVNRGISQAPVTATEDLEIRNNAANYLPQISHL .. .. ::. : : ::: :: : ... .. .. : . . : . . . . CCDS34 MRAHAAALGVQD-YLLFAEMLMQRPV-RLGQLWGSHLLSREEAAYMVDMARERFEAVMAV 420 430 440 450 460 430 440 450 460 470 pF1KE0 LNHVPRQMLLILKTNDLLRGIEAALGTRASASSFLNMSRCCIR-----ALAEHKKKNTCS : ..:: :::.:.. . .:.:..::: : .. .. :.. .: : : .. : CCDS34 LRELPRPMLLVLRNINTVRAINVALG--APVDRYFLMAKRAVRGWSRLAGATYRGVYGTS 470 480 490 500 510 520 480 490 500 510 520 pF1KE0 FFRRTQISFSEAFNLWQINLHELILRVKGLKLADRVLALICWLFPAPL ..:.... .:.. :. ::.. : . :. ::. CCDS34 LLRHAKV-------VWEMLKFEVALRLETLAM--RLTALLARALVHLSLVPPAEELYQYL 530 540 550 560 570 CCDS34 ET 580 >>CCDS1557.1 COQ8A gene_id:56997|Hs108|chr1 (647 aa) initn: 229 init1: 229 opt: 362 Z-score: 426.9 bits: 88.9 E(32554): 1.9e-17 Smith-Waterman score: 365; 27.2% identity (59.6% similar) in 334 aa overlap (33-363:216-535) 10 20 30 40 50 60 pF1KE0 RKALKLASWTSMALAASGIYFYSNKYLDPNDFGAVRVGRAVATTAVISYDYLTSLKSVPY .::.. :: . .. : .. : : : CCDS15 ARPENKQHKQTLSEHARERKVPVTRIGRLANFGGLAVGLGFGALAEVAKKSLRSED--PS 190 200 210 220 230 240 70 80 90 100 110 120 pF1KE0 GSEEYLQLRSKVHLRSARRLCELCCANRGTFIKVGQHLGALD--YLLPEEYTSTLKVLHS :.. : . .:.:. . : ::. .:.:: :. : .. :. .. .. ... CCDS15 GKKAVLGSSPFLSEANAERIVRTLCKVRGAALKLGQMLSIQDDAFINPH-LAKIFERVRQ 250 260 270 280 290 300 130 140 150 160 170 180 pF1KE0 QAPQSSMQEIRQVIREDLGKEIHDLFQSFDDTPLGTASLAQVHKAVLHDGRTVAVKVQHP .: .... ... .::: . .: .. :.. :...::..::: : .. :: ::.:.:.: CCDS15 SADFMPLKQMMKTLNNDLGPNWRDKLEYFEERPFAAASIGQVHLARMKGGREVAMKIQYP 310 320 330 340 350 360 190 200 210 220 230 pF1KE0 KVRAQSSKDILLMEVLVLAVKQLFPEFEF-MWLVDEAKKNLPLELDFLNEGRNAEKVSQM : ::: .. . . :: .....:: : :.: ...: :: :. :. :.: .. CCDS15 GV-AQSINSDVNNLMAVLNMSNMLPEGLFPEHLIDVLRRELALECDYQREAACARKFRDL 370 380 390 400 410 420 240 250 260 270 280 290 pF1KE0 LRHFDFLKVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMI :. :. ::.: .: . .:: :.:.: ... . . . .: ::: .. . . . CCDS15 LKGHPFFYVPEIVDELCSPHVLTTELVSGFPLDQAEGLSQ-EIR-NEICYNILVLCLREL 430 440 450 460 470 300 310 320 330 340 350 pF1KE0 FVNGFVHCDPHPGNVLVRKHPGTGKAEIVLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMK : :.. ::. .: . : : ..::: : :.:. .. :. ..: . CCDS15 FEFHFMQTDPNWSNFFY--DPQQHK--VALLDFGA----TREYDRSFTDLYIQIIRAAAD 480 490 500 510 520 530 360 370 380 390 400 410 pF1KE0 RVKEYSQRLGAGDLYPLFACMLTARSWDSVNRGISQAPVTATEDLEIRNNAANYLPQISH : .: CCDS15 RDRETVRAKSIEMKFLTGYEVKVMEDAHLDAILILGEAFASDEPFDFGTQSTTEKIHNLI 540 550 560 570 580 590 >>CCDS12562.1 COQ8B gene_id:79934|Hs108|chr19 (544 aa) initn: 244 init1: 209 opt: 353 Z-score: 417.4 bits: 86.9 E(32554): 6.3e-17 Smith-Waterman score: 353; 27.9% identity (57.6% similar) in 344 aa overlap (33-368:94-423) 10 20 30 40 50 60 pF1KE0 RKALKLASWTSMALAASGIYFYSNKYLDPNDFGAVRVGRAVATTAVISYDYLTSLKSVPY .::.. :: .... : .. ::.: CCDS12 EARPRKTPRPQLSDRSRERKVPASRISRLANFGGLAVGLGLGVLAEMAK------KSMPG 70 80 90 100 110 70 80 90 100 110 pF1KE0 G---SEEYLQLRSKVHLR--SARRLCELCCANRGTFIKVGQHLGALD--YLLPEEYTSTL : :: : :. : .:.:. . :. ::. .:::: :. : .. :. CCDS12 GRLQSEGGSGLDSSPFLSEANAERIVQTLCTVRGAALKVGQMLSIQDNSFISPQLQHIFE 120 130 140 150 160 170 120 130 140 150 160 170 pF1KE0 KVLHSQAPQSSMQEIRQVIREDLGKEIHDLFQSFDDTPLGTASLAQVHKAVLHDGRTVAV .: .: . : .: :..:.::.. . :....:...::..:::...:.:: ::: CCDS12 RVRQSADFMPRWQMLR-VLEEELGRDWQAKVASLEEVPFAAASIGQVHQGLLRDGTEVAV 180 190 200 210 220 230 180 190 200 210 220 230 pF1KE0 KVQHPKVRAQSSKDILLMEVLVLAVKQLFPEFEFMWLVDEA-KKNLPLELDFLNEGRNAE :.:.: . ::: .. . . :: .. .: : .: ...: : :. :. :. CCDS12 KIQYPGI-AQSIQSDVQNLLAVLKMSAALPAGLFAEQSLQALQQELAWECDYRREAACAQ 240 250 260 270 280 290 240 250 260 270 280 290 pF1KE0 KVSQMLRHFDFLKVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKM . :.: . :..:: . .: : ::: ::.. : ... . . .. :.: .: . CCDS12 NFRQLLANDPFFRVPAVVKELCTTRVLGMELAGGVPLDQCQGLSQDL--RNQICFQLLTL 300 310 320 330 340 350 300 310 320 330 340 350 pF1KE0 YSEMIFVNGFVHCDPHPGNVLVRKHPGTGKAEIVLLDHGLYQMLTEEFRLNYCHLWQSLI . .: :.. ::. .: : ... ...::: : . . :: .: .. .. CCDS12 CLRELFEFRFMQTDPNWANFLY----DASSHQVTLLDFGASREFGTEFTDHYIEVVKAAA 360 370 380 390 400 360 370 380 390 400 410 pF1KE0 WTDMKRVKEYSQRLGAGDLYPLFACMLTARSWDSVNRGISQAPVTATEDLEIRNNAANYL : : . :. : CCDS12 DGDRDCVLQKSRDLKFLTGFETKAFSDAHVEAVMILGEPFATQGPYDFGSGETARRIQDL 410 420 430 440 450 460 >>CCDS46081.1 COQ8B gene_id:79934|Hs108|chr19 (503 aa) initn: 209 init1: 209 opt: 282 Z-score: 334.0 bits: 71.4 E(32554): 2.8e-12 Smith-Waterman score: 285; 26.7% identity (56.0% similar) in 318 aa overlap (68-368:75-382) 40 50 60 70 80 90 pF1KE0 RVGRAVATTAVISYDYLTSLKSVPYGSEEYLQLRSKVHLRSARRLCELCCANRGTFIKVG :. ::. . : :. .: :: : . :: CCDS46 FYQDGPGRGLGEEDIRRAREARPRKTPRPQLSDRSRERKVPASRISRL--ANFGG-LAVG 50 60 70 80 90 100 100 110 120 130 140 pF1KE0 QHLGALDYL----LPEEYTSTLKVLHSQAPQSSMQEIRQ------------VIREDLGKE ::.: . .: .. . . : : ....:: :..:.::.. CCDS46 LGLGVLAEMAKKSMPGGRLQSDNSFISPQLQHIFERVRQSADFMPRWQMLRVLEEELGRD 110 120 130 140 150 160 150 160 170 180 190 200 pF1KE0 IHDLFQSFDDTPLGTASLAQVHKAVLHDGRTVAVKVQHPKVRAQSSKDILLMEVLVLAVK . :....:...::..:::...:.:: ::::.:.: . ::: .. . . :: .. CCDS46 WQAKVASLEEVPFAAASIGQVHQGLLRDGTEVAVKIQYPGI-AQSIQSDVQNLLAVLKMS 170 180 190 200 210 220 210 220 230 240 250 260 pF1KE0 QLFPEFEFMWLVDEA-KKNLPLELDFLNEGRNAEKVSQMLRHFDFLKVPRIHWDLSTERV .: : .: ...: : :. :. :.. :.: . :..:: . .: : :: CCDS46 AALPAGLFAEQSLQALQQELAWECDYRREAACAQNFRQLLANDPFFRVPAVVKELCTTRV 230 240 250 260 270 280 270 280 290 300 310 320 pF1KE0 LLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIFVNGFVHCDPHPGNVLVRKHP : ::.. : ... . . .. :.: .: . . .: :.. ::. .: : CCDS46 LGMELAGGVPLDQCQGLSQDL--RNQICFQLLTLCLRELFEFRFMQTDPNWANFLY---- 290 300 310 320 330 330 340 350 360 370 380 pF1KE0 GTGKAEIVLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKRVKEYSQRLGAGDLYPLFACM ... ...::: : . . :: .: .. .. : : . :. : CCDS46 DASSHQVTLLDFGASREFGTEFTDHYIEVVKAAADGDRDCVLQKSRDLKFLTGFETKAFS 340 350 360 370 380 390 390 400 410 420 430 440 pF1KE0 LTARSWDSVNRGISQAPVTATEDLEIRNNAANYLPQISHLLNHVPRQMLLILKTNDLLRG CCDS46 DAHVEAVMILGEPFATQGPYDFGSGETARRIQDLIPVLLRHRLCPPPEETYALHRKLAGA 400 410 420 430 440 450 523 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 12:09:06 2016 done: Sat Nov 5 12:09:07 2016 Total Scan time: 3.170 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]