FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0971, 540 aa 1>>>pF1KE0971 540 - 540 aa - 540 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.3000+/-0.00163; mu= -0.8455+/- 0.093 mean_var=412.7435+/-94.006, 0's: 0 Z-trim(106.6): 383 B-trim: 0 in 0/52 Lambda= 0.063130 statistics sampled from 8636 (9055) to 8636 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.649), E-opt: 0.2 (0.278), width: 16 Scan time: 3.130 The best scores are: opt bits E(32554) CCDS6247.1 RIPK2 gene_id:8767|Hs108|chr8 ( 540) 3615 344.8 1.5e-94 CCDS13675.1 RIPK4 gene_id:54101|Hs108|chr21 ( 784) 692 78.8 2.6e-14 CCDS44734.1 ANKK1 gene_id:255239|Hs108|chr11 ( 765) 665 76.4 1.4e-13 >>CCDS6247.1 RIPK2 gene_id:8767|Hs108|chr8 (540 aa) initn: 3615 init1: 3615 opt: 3615 Z-score: 1811.0 bits: 344.8 E(32554): 1.5e-94 Smith-Waterman score: 3615; 100.0% identity (100.0% similar) in 540 aa overlap (1-540:1-540) 10 20 30 40 50 60 pF1KE0 MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS62 MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSER 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 KDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS62 KDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 RFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS62 RFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 SKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS62 SKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 SVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS62 SVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 TFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS62 TFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPET 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 SRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS62 SRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIIN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 PLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS62 PLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE0 PTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS62 PTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM 490 500 510 520 530 540 >>CCDS13675.1 RIPK4 gene_id:54101|Hs108|chr21 (784 aa) initn: 570 init1: 263 opt: 692 Z-score: 370.5 bits: 78.8 E(32554): 2.6e-14 Smith-Waterman score: 700; 37.4% identity (61.1% similar) in 380 aa overlap (27-384:31-393) 10 20 30 40 50 pF1KE0 MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVK---HLHIHT :. : : ..::. :.. .:.: ::. CCDS13 MEGDGGTPWALALLRTFDAGEFTGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVD- 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 PLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEY : :: ..:.::. .. :.: ::::. ::: :: .:.: ::: .:::..:: . CCDS13 ---DRERMELLEEAKKMEMAKFRYILPVYGICREP--VGLVMEYMETGSLEKLLASE--- 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 PDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMM : . : :::::.:: :.:.:.:: :.::::: ::: ::::: ..::::.::::.: CCDS13 P-LPWDLRFRIIHETAVGMNFLHCMAPPLLHLDLKPANILLDAHYHVKISDFGLAK--CN 120 130 140 150 160 180 190 200 210 220 230 pF1KE0 SLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRA-SIKHDIYSYAVITWEVLSRKQPFEDV .::.:.. . ::: :.::: . .::: . :::.::.:.. : ::..:.:: : CCDS13 GLSHSHDLSMDGLFGTIAYLPPERIR--EKSRLFDTKHDVYSFAIVIWGVLTQKKPFADE 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE0 TNPLQIMYSVSQGHRPVINE--ESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIEL : :.:: .: .:::: . .. : : .: :.. : .: ::.: . : CCDS13 KNILHIMVKVVKGHRPELPPVCRARPRACSH---LIRLMQRCWQGDPRVRPTFQEITSET 230 240 250 260 270 280 300 310 320 330 pF1KE0 EPVL-RTFEEITFLEAVIQLKK----------TKLQSVSSAIHLCDKKKMEL--SLNIPV : . . .:. ...:. ..:. .:. : . :: .:. : CCDS13 EDLCEKPDDEVKETAHDLDVKSPPEPRSEVVPARLKRASAPTFDNDYSLSELLSQLDSGV 290 300 310 320 330 340 340 350 360 370 380 390 pF1KE0 NH---GPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSW .. ::.: : .::. . :.. : . :. : :: . . : . CCDS13 SQAVEGPEELSRSSSESKLPSSGSGKRLSGVSSVDSAFSSRGSLSLSFEREPSTSDLGTT 350 360 370 380 390 400 400 410 420 430 440 450 pF1KE0 DSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEA CCDS13 DVQKKKLVDAIVSGDTSKLMKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNAN 410 420 430 440 450 460 >>CCDS44734.1 ANKK1 gene_id:255239|Hs108|chr11 (765 aa) initn: 453 init1: 261 opt: 665 Z-score: 357.3 bits: 76.4 E(32554): 1.4e-13 Smith-Waterman score: 679; 34.0% identity (62.8% similar) in 379 aa overlap (9-382:12-359) 10 20 30 40 50 pF1KE0 MNGEAICSALPTIPYHKL-ADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLL .::.. . .: : .. :. . : .::: ::.. :.: : CCDS44 MAADPTELRLGSLPVFTRDDFEGDWRLVASGGFSQVFQARHRRWRTEYAIKCAPCLPP-- 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 DSERKDV---LREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEY :. .:: ..:: ..: .:..:. : :.:..: :::: :.: ::::...: .. CCDS44 DAASSDVNYLIEEAAKMKKIKFQHIVSIYGVCKQP--LGIVMEFMANGSLEKVLSTHS-- 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 PDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMM . : :::::.:: .:..:.::.. ::::: ::: :::::...::::.::::::: . CCDS44 --LCWKLRFRIIHETSLAMNFLHSIKPPLLHLDLKPGNILLDSNMHVKISDFGLSKWMEQ 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 SLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVT : .. .:: .: . :.::: . ..:. . :.:.::.:.. ::.:..:.:. CCDS44 STRMQYIERSALRG-MLSYIPPEMFLESNKA-PGPKYDVYSFAIVIWELLTQKKPYSGF- 180 190 200 210 220 240 250 260 270 280 290 pF1KE0 NPLQIMYSVSQGHRPVINEESLPYDIPHRAR-MISLIESGWAQNPDERPSFLKCLIELEP : ..:. :. : :: .. : . : .:. :..:.. : :.: .:: :: :: . CCDS44 NMMMIIIRVAAGMRPSLQPVSDQW--PSEAQQMVDLMKRCWDQDPKKRPCFLDITIETDI 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE0 VLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLH .: ..:.. . . ..: : : . .::: : : .:. .. . CCDS44 LL------SLLQSRVAVPESKA--------LARKVSCKLSLRQP---GEVNEDISQELMD 290 300 310 320 330 360 370 380 390 400 410 pF1KE0 ENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTT .::. .:.: . .... : . : . CCDS44 SDSGN-YLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVD 340 350 360 370 380 540 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 20:31:10 2016 done: Sat Nov 5 20:31:11 2016 Total Scan time: 3.130 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]