FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0988, 619 aa 1>>>pF1KE0988 619 - 619 aa - 619 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.0995+/-0.000552; mu= 3.7708+/- 0.033 mean_var=773.0982+/-180.725, 0's: 0 Z-trim(116.8): 1225 B-trim: 0 in 0/61 Lambda= 0.046127 statistics sampled from 26531 (28305) to 26531 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.686), E-opt: 0.2 (0.332), width: 16 Scan time: 11.230 The best scores are: opt bits E(85289) NP_001070 (OMIM: 176947,269840,617006) tyrosine-pr ( 619) 4255 300.0 1.6e-80 XP_016860356 (OMIM: 176947,269840,617006) PREDICTE ( 742) 4255 300.1 1.7e-80 XP_016860357 (OMIM: 176947,269840,617006) PREDICTE ( 736) 4196 296.2 2.6e-79 XP_016860358 (OMIM: 176947,269840,617006) PREDICTE ( 730) 3975 281.5 7.1e-75 XP_016860359 (OMIM: 176947,269840,617006) PREDICTE ( 707) 3969 281.1 9.2e-75 NP_001128524 (OMIM: 600085) tyrosine-protein kinas ( 612) 2364 174.1 1.2e-42 NP_001167639 (OMIM: 600085) tyrosine-protein kinas ( 612) 2364 174.1 1.2e-42 NP_997402 (OMIM: 176947,269840,617006) tyrosine-pr ( 312) 2135 158.3 3.6e-38 NP_003168 (OMIM: 600085) tyrosine-protein kinase S ( 635) 1094 89.7 3.4e-17 XP_005252204 (OMIM: 600085) PREDICTED: tyrosine-pr ( 635) 1094 89.7 3.4e-17 NP_001167638 (OMIM: 600085) tyrosine-protein kinas ( 635) 1094 89.7 3.4e-17 XP_011517248 (OMIM: 600085) PREDICTED: tyrosine-pr ( 635) 1094 89.7 3.4e-17 XP_016869178 (OMIM: 600758) PREDICTED: focal adhes ( 919) 738 66.3 5.4e-10 XP_016869177 (OMIM: 600758) PREDICTED: focal adhes ( 919) 738 66.3 5.4e-10 XP_016869168 (OMIM: 600758) PREDICTED: focal adhes (1011) 738 66.4 5.7e-10 XP_016869166 (OMIM: 600758) PREDICTED: focal adhes (1032) 738 66.4 5.7e-10 XP_016869179 (OMIM: 600758) PREDICTED: focal adhes ( 913) 736 66.1 6e-10 XP_016869176 (OMIM: 600758) PREDICTED: focal adhes ( 934) 736 66.2 6e-10 XP_016869173 (OMIM: 600758) PREDICTED: focal adhes ( 949) 736 66.2 6.1e-10 XP_016869172 (OMIM: 600758) PREDICTED: focal adhes ( 955) 736 66.2 6.1e-10 NP_001303271 (OMIM: 600758) focal adhesion kinase ( 955) 736 66.2 6.1e-10 XP_016869170 (OMIM: 600758) PREDICTED: focal adhes ( 980) 736 66.2 6.1e-10 XP_006716673 (OMIM: 600758) PREDICTED: focal adhes ( 983) 736 66.2 6.1e-10 XP_005251070 (OMIM: 600758) PREDICTED: focal adhes ( 983) 736 66.2 6.1e-10 XP_006716672 (OMIM: 600758) PREDICTED: focal adhes ( 983) 736 66.2 6.1e-10 XP_016869169 (OMIM: 600758) PREDICTED: focal adhes ( 995) 736 66.2 6.2e-10 XP_016869164 (OMIM: 600758) PREDICTED: focal adhes (1047) 736 66.2 6.3e-10 XP_016869163 (OMIM: 600758) PREDICTED: focal adhes (1047) 736 66.2 6.3e-10 XP_016869158 (OMIM: 600758) PREDICTED: focal adhes (1059) 736 66.3 6.3e-10 XP_016869156 (OMIM: 600758) PREDICTED: focal adhes (1060) 736 66.3 6.3e-10 XP_016869157 (OMIM: 600758) PREDICTED: focal adhes (1060) 736 66.3 6.3e-10 XP_016869152 (OMIM: 600758) PREDICTED: focal adhes (1062) 736 66.3 6.3e-10 XP_016869151 (OMIM: 600758) PREDICTED: focal adhes (1062) 736 66.3 6.3e-10 XP_016869149 (OMIM: 600758) PREDICTED: focal adhes (1068) 736 66.3 6.4e-10 XP_016869150 (OMIM: 600758) PREDICTED: focal adhes (1068) 736 66.3 6.4e-10 XP_016869141 (OMIM: 600758) PREDICTED: focal adhes (1075) 736 66.3 6.4e-10 XP_016869140 (OMIM: 600758) PREDICTED: focal adhes (1093) 736 66.3 6.4e-10 XP_005251069 (OMIM: 600758) PREDICTED: focal adhes (1096) 736 66.3 6.4e-10 XP_011515496 (OMIM: 600758) PREDICTED: focal adhes (1096) 736 66.3 6.4e-10 XP_006716671 (OMIM: 600758) PREDICTED: focal adhes (1096) 736 66.3 6.4e-10 XP_016869145 (OMIM: 600758) PREDICTED: focal adhes (1103) 736 66.3 6.5e-10 XP_016869144 (OMIM: 600758) PREDICTED: focal adhes (1104) 736 66.3 6.5e-10 XP_016869143 (OMIM: 600758) PREDICTED: focal adhes (1106) 736 66.3 6.5e-10 XP_016869142 (OMIM: 600758) PREDICTED: focal adhes (1112) 736 66.3 6.5e-10 XP_005251060 (OMIM: 600758) PREDICTED: focal adhes (1140) 736 66.3 6.5e-10 XP_016869175 (OMIM: 600758) PREDICTED: focal adhes ( 942) 733 66.0 6.9e-10 XP_016869174 (OMIM: 600758) PREDICTED: focal adhes ( 948) 733 66.0 7e-10 XP_016869171 (OMIM: 600758) PREDICTED: focal adhes ( 976) 733 66.0 7e-10 XP_016869167 (OMIM: 600758) PREDICTED: focal adhes (1016) 733 66.0 7.2e-10 XP_016869148 (OMIM: 600758) PREDICTED: focal adhes (1031) 733 66.0 7.2e-10 >>NP_001070 (OMIM: 176947,269840,617006) tyrosine-protei (619 aa) initn: 4255 init1: 4255 opt: 4255 Z-score: 1566.5 bits: 300.0 E(85289): 1.6e-80 Smith-Waterman score: 4255; 100.0% identity (100.0% similar) in 619 aa overlap (1-619:1-619) 10 20 30 40 50 60 pF1KE0 MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 IERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 AMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 AQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 LKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTLTHPQRRIDTLNSDGYTPEPARIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTLTHPQRRIDTLNSDGYTPEPARIT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 SPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 KKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 PLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDF 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE0 GLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPY 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE0 KKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSL 550 560 570 580 590 600 610 pF1KE0 ASKVEGPPGSTQKAEAACA ::::::::::::::::::: NP_001 ASKVEGPPGSTQKAEAACA 610 >>XP_016860356 (OMIM: 176947,269840,617006) PREDICTED: t (742 aa) initn: 4255 init1: 4255 opt: 4255 Z-score: 1565.9 bits: 300.1 E(85289): 1.7e-80 Smith-Waterman score: 4255; 100.0% identity (100.0% similar) in 619 aa overlap (1-619:124-742) 10 20 30 pF1KE0 MPDPAAHLPFFYGSISRAEAEEHLKLAGMA :::::::::::::::::::::::::::::: XP_016 WREAGKCVPGRKHPRQEGTGVHEVSGGPGAMPDPAAHLPFFYGSISRAEAEEHLKLAGMA 100 110 120 130 140 150 40 50 60 70 80 90 pF1KE0 DGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTYAIAGGKAHCGPAELCEFYSRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTYAIAGGKAHCGPAELCEFYSRD 160 170 180 190 200 210 100 110 120 130 140 150 pF1KE0 PDGLPCNLRKPCNRPSGLEPQPGVFDCLRDAMVRDYVRQTWKLEGEALEQAIISQAPQVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PDGLPCNLRKPCNRPSGLEPQPGVFDCLRDAMVRDYVRQTWKLEGEALEQAIISQAPQVE 220 230 240 250 260 270 160 170 180 190 200 210 pF1KE0 KLIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLIYGKTVYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KLIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLIYGKTVYH 280 290 300 310 320 330 220 230 240 250 260 270 pF1KE0 YLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTL 340 350 360 370 380 390 280 290 300 310 320 330 pF1KE0 PAHPSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDKKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PAHPSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDKKL 400 410 420 430 440 450 340 350 360 370 380 390 pF1KE0 FLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIM 460 470 480 490 500 510 400 410 420 430 440 450 pF1KE0 HQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMK 520 530 540 550 560 570 460 470 480 490 500 510 pF1KE0 YLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC 580 590 600 610 620 630 520 530 540 550 560 570 pF1KE0 INFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 INFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYA 640 650 660 670 680 690 580 590 600 610 pF1KE0 LMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQKAEAACA ::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQKAEAACA 700 710 720 730 740 >>XP_016860357 (OMIM: 176947,269840,617006) PREDICTED: t (736 aa) initn: 2262 init1: 2186 opt: 4196 Z-score: 1544.7 bits: 296.2 E(85289): 2.6e-79 Smith-Waterman score: 4196; 99.0% identity (99.0% similar) in 619 aa overlap (1-619:124-736) 10 20 30 pF1KE0 MPDPAAHLPFFYGSISRAEAEEHLKLAGMA :::::::::::::::::::::::::::::: XP_016 WREAGKCVPGRKHPRQEGTGVHEVSGGPGAMPDPAAHLPFFYGSISRAEAEEHLKLAGMA 100 110 120 130 140 150 40 50 60 70 80 90 pF1KE0 DGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTYAIAGGKAHCGPAELCEFYSRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTYAIAGGKAHCGPAELCEFYSRD 160 170 180 190 200 210 100 110 120 130 140 150 pF1KE0 PDGLPCNLRKPCNRPSGLEPQPGVFDCLRDAMVRDYVRQTWKLEGEALEQAIISQAPQVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PDGLPCNLRKPCNRPSGLEPQPGVFDCLRDAMVRDYVRQTWKLEGEALEQAIISQAPQVE 220 230 240 250 260 270 160 170 180 190 200 210 pF1KE0 KLIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLIYGKTVYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KLIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLIYGKTVYH 280 290 300 310 320 330 220 230 240 250 260 270 pF1KE0 YLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTL 340 350 360 370 380 390 280 290 300 310 320 330 pF1KE0 PAHPSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDKKL :::::::::::::::::::::::::: :::::::::::::::::::::::::::: XP_016 PAHPSTLTHPQRRIDTLNSDGYTPEP------DKPRPMPMDTSVYESPYSDPEELKDKKL 400 410 420 430 440 340 350 360 370 380 390 pF1KE0 FLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIM 450 460 470 480 490 500 400 410 420 430 440 450 pF1KE0 HQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMK 510 520 530 540 550 560 460 470 480 490 500 510 pF1KE0 YLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC 570 580 590 600 610 620 520 530 540 550 560 570 pF1KE0 INFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 INFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYA 630 640 650 660 670 680 580 590 600 610 pF1KE0 LMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQKAEAACA ::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQKAEAACA 690 700 710 720 730 >>XP_016860358 (OMIM: 176947,269840,617006) PREDICTED: t (730 aa) initn: 3975 init1: 3975 opt: 3975 Z-score: 1465.3 bits: 281.5 E(85289): 7.1e-75 Smith-Waterman score: 3975; 100.0% identity (100.0% similar) in 579 aa overlap (1-579:124-702) 10 20 30 pF1KE0 MPDPAAHLPFFYGSISRAEAEEHLKLAGMA :::::::::::::::::::::::::::::: XP_016 WREAGKCVPGRKHPRQEGTGVHEVSGGPGAMPDPAAHLPFFYGSISRAEAEEHLKLAGMA 100 110 120 130 140 150 40 50 60 70 80 90 pF1KE0 DGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTYAIAGGKAHCGPAELCEFYSRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTYAIAGGKAHCGPAELCEFYSRD 160 170 180 190 200 210 100 110 120 130 140 150 pF1KE0 PDGLPCNLRKPCNRPSGLEPQPGVFDCLRDAMVRDYVRQTWKLEGEALEQAIISQAPQVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PDGLPCNLRKPCNRPSGLEPQPGVFDCLRDAMVRDYVRQTWKLEGEALEQAIISQAPQVE 220 230 240 250 260 270 160 170 180 190 200 210 pF1KE0 KLIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLIYGKTVYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KLIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLIYGKTVYH 280 290 300 310 320 330 220 230 240 250 260 270 pF1KE0 YLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTL 340 350 360 370 380 390 280 290 300 310 320 330 pF1KE0 PAHPSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDKKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PAHPSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDKKL 400 410 420 430 440 450 340 350 360 370 380 390 pF1KE0 FLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIM 460 470 480 490 500 510 400 410 420 430 440 450 pF1KE0 HQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMK 520 530 540 550 560 570 460 470 480 490 500 510 pF1KE0 YLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC 580 590 600 610 620 630 520 530 540 550 560 570 pF1KE0 INFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 INFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYA 640 650 660 670 680 690 580 590 600 610 pF1KE0 LMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQKAEAACA ::::::::: XP_016 LMSDCWIYKVSSAHADSPLGLCIHRCRCLESSPRPHR 700 710 720 730 >>XP_016860359 (OMIM: 176947,269840,617006) PREDICTED: t (707 aa) initn: 3969 init1: 3969 opt: 3969 Z-score: 1463.2 bits: 281.1 E(85289): 9.2e-75 Smith-Waterman score: 3969; 100.0% identity (100.0% similar) in 578 aa overlap (1-578:124-701) 10 20 30 pF1KE0 MPDPAAHLPFFYGSISRAEAEEHLKLAGMA :::::::::::::::::::::::::::::: XP_016 WREAGKCVPGRKHPRQEGTGVHEVSGGPGAMPDPAAHLPFFYGSISRAEAEEHLKLAGMA 100 110 120 130 140 150 40 50 60 70 80 90 pF1KE0 DGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTYAIAGGKAHCGPAELCEFYSRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTYAIAGGKAHCGPAELCEFYSRD 160 170 180 190 200 210 100 110 120 130 140 150 pF1KE0 PDGLPCNLRKPCNRPSGLEPQPGVFDCLRDAMVRDYVRQTWKLEGEALEQAIISQAPQVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PDGLPCNLRKPCNRPSGLEPQPGVFDCLRDAMVRDYVRQTWKLEGEALEQAIISQAPQVE 220 230 240 250 260 270 160 170 180 190 200 210 pF1KE0 KLIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLIYGKTVYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KLIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLIYGKTVYH 280 290 300 310 320 330 220 230 240 250 260 270 pF1KE0 YLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTL 340 350 360 370 380 390 280 290 300 310 320 330 pF1KE0 PAHPSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDKKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PAHPSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDKKL 400 410 420 430 440 450 340 350 360 370 380 390 pF1KE0 FLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIM 460 470 480 490 500 510 400 410 420 430 440 450 pF1KE0 HQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMK 520 530 540 550 560 570 460 470 480 490 500 510 pF1KE0 YLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC 580 590 600 610 620 630 520 530 540 550 560 570 pF1KE0 INFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 INFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYA 640 650 660 670 680 690 580 590 600 610 pF1KE0 LMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQKAEAACA :::::::: XP_016 LMSDCWIYNPSPSS 700 >>NP_001128524 (OMIM: 600085) tyrosine-protein kinase SY (612 aa) initn: 2251 init1: 1046 opt: 2364 Z-score: 886.5 bits: 174.1 E(85289): 1.2e-42 Smith-Waterman score: 2364; 56.2% identity (80.6% similar) in 608 aa overlap (1-602:6-612) 10 20 30 40 50 pF1KE0 MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVR : : : :::::.:.:.: :::..: .::.:::.:::: :::..::..: . NP_001 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 FHHFPIERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVF ::. :::.::::::::::..: .::.::...:.. ::: : :.:: :::.:..:. : : NP_001 AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 DCLRDAMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAER . :.. ..:.::.:::.:.:.::::::::: ::.::::::::::.:::.:....:::.:. NP_001 EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE0 KLYSGAQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQL . :..:.::::.: : ..:.::: :.. : :: :..::.:: :::: :::::::: NP_001 IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE0 VEYLKLKADGLIYCLKEACPN-SSASNASGAAAPTLP-AHP-STLTHPQRRIDTLNSDGY ::. . :::::. : : . .. .:.. .. : :: .:: :. .. .:. .:.. . : NP_001 VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPASSPAQGNRQESTVSFNPY 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE0 TPEPARITSPDKPR--PMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFG :: : .. :. .:::: ::::::.::::.. :...: : : . : ::: :::: NP_001 EPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFG 310 320 330 340 350 360 360 370 380 390 400 pF1KE0 SVRQGVYRMRKKQIDVAIKVLK-QGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEA .:..: :.:.: ::.:.:: .... : .:.. ::..:.:::::::::.::.:.::. NP_001 TVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAES 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE0 LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLL ::::::: :::.:.: .:. . .:. ::.::::::::::::.:::::::::::::: NP_001 WMLVMEMAELGPLNKYLQQNRH-VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLL 430 440 450 460 470 470 480 490 500 510 520 pF1KE0 VNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTM :..:::::::::::::: ::..:: :.. ::::.:::::::::. ::::.:::::.:: : NP_001 VTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLM 480 490 500 510 520 530 530 540 550 560 570 580 pF1KE0 WEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTV :::.:::::::. ::: :: :..:.:.:: :: :: :.: ::. :: : :.:: : .: NP_001 WEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAV 540 550 560 570 580 590 590 600 610 pF1KE0 EQRMRACYYSLASKVEGPPGSTQKAEAACA : :.: ::.... NP_001 ELRLRNYYYDVVN 600 610 >>NP_001167639 (OMIM: 600085) tyrosine-protein kinase SY (612 aa) initn: 2251 init1: 1046 opt: 2364 Z-score: 886.5 bits: 174.1 E(85289): 1.2e-42 Smith-Waterman score: 2364; 56.2% identity (80.6% similar) in 608 aa overlap (1-602:6-612) 10 20 30 40 50 pF1KE0 MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVR : : : :::::.:.:.: :::..: .::.:::.:::: :::..::..: . NP_001 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 FHHFPIERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVF ::. :::.::::::::::..: .::.::...:.. ::: : :.:: :::.:..:. : : NP_001 AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 DCLRDAMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAER . :.. ..:.::.:::.:.:.::::::::: ::.::::::::::.:::.:....:::.:. NP_001 EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE0 KLYSGAQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQL . :..:.::::.: : ..:.::: :.. : :: :..::.:: :::: :::::::: NP_001 IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE0 VEYLKLKADGLIYCLKEACPN-SSASNASGAAAPTLP-AHP-STLTHPQRRIDTLNSDGY ::. . :::::. : : . .. .:.. .. : :: .:: :. .. .:. .:.. . : NP_001 VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPASSPAQGNRQESTVSFNPY 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE0 TPEPARITSPDKPR--PMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFG :: : .. :. .:::: ::::::.::::.. :...: : : . : ::: :::: NP_001 EPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFG 310 320 330 340 350 360 360 370 380 390 400 pF1KE0 SVRQGVYRMRKKQIDVAIKVLK-QGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEA .:..: :.:.: ::.:.:: .... : .:.. ::..:.:::::::::.::.:.::. NP_001 TVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAES 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE0 LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLL ::::::: :::.:.: .:. . .:. ::.::::::::::::.:::::::::::::: NP_001 WMLVMEMAELGPLNKYLQQNRH-VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLL 430 440 450 460 470 470 480 490 500 510 520 pF1KE0 VNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTM :..:::::::::::::: ::..:: :.. ::::.:::::::::. ::::.:::::.:: : NP_001 VTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLM 480 490 500 510 520 530 530 540 550 560 570 580 pF1KE0 WEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTV :::.:::::::. ::: :: :..:.:.:: :: :: :.: ::. :: : :.:: : .: NP_001 WEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAV 540 550 560 570 580 590 590 600 610 pF1KE0 EQRMRACYYSLASKVEGPPGSTQKAEAACA : :.: ::.... NP_001 ELRLRNYYYDVVN 600 610 >>NP_997402 (OMIM: 176947,269840,617006) tyrosine-protei (312 aa) initn: 2135 init1: 2135 opt: 2135 Z-score: 806.3 bits: 158.3 E(85289): 3.6e-38 Smith-Waterman score: 2135; 100.0% identity (100.0% similar) in 312 aa overlap (308-619:1-312) 280 290 300 310 320 330 pF1KE0 THPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDNL :::::::::::::::::::::::::::::: NP_997 MPMDTSVYESPYSDPEELKDKKLFLKRDNL 10 20 30 340 350 360 370 380 390 pF1KE0 LIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 LIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPY 40 50 60 70 80 90 400 410 420 430 440 450 pF1KE0 IVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 IVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNF 100 110 120 130 140 150 460 470 480 490 500 510 pF1KE0 VHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 VHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFS 160 170 180 190 200 210 520 530 540 550 560 570 pF1KE0 SRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 SRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWI 220 230 240 250 260 270 580 590 600 610 pF1KE0 YKWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQKAEAACA :::::::::::::::::::::::::::::::::::::::::: NP_997 YKWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQKAEAACA 280 290 300 310 >>NP_003168 (OMIM: 600085) tyrosine-protein kinase SYK i (635 aa) initn: 2251 init1: 1046 opt: 1094 Z-score: 429.6 bits: 89.7 E(85289): 3.4e-17 Smith-Waterman score: 2324; 54.4% identity (77.7% similar) in 631 aa overlap (1-602:6-635) 10 20 30 40 50 pF1KE0 MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVR : : : :::::.:.:.: :::..: .::.:::.:::: :::..::..: . NP_003 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 FHHFPIERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVF ::. :::.::::::::::..: .::.::...:.. ::: : :.:: :::.:..:. : : NP_003 AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 DCLRDAMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAER . :.. ..:.::.:::.:.:.::::::::: ::.::::::::::.:::.:....:::.:. NP_003 EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE0 KLYSGAQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQL . :..:.::::.: : ..:.::: :.. : :: :..::.:: :::: :::::::: NP_003 IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL 190 200 210 220 230 240 240 250 260 270 280 pF1KE0 VEYLKLKADGLIYCLKEACPN-SSASNASGAAAPTLP-AHPST------------LTHPQ ::. . :::::. : : . .. .:.. .. : :: .::.: . :. NP_003 VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK 250 260 270 280 290 300 290 300 310 320 pF1KE0 ------------RRIDTLNSDGYTPEPARITSPDKPR--PMPMDTSVYESPYSDPEELKD :. .:.. . : :: : .. :. .:::: ::::::.::::.. NP_003 PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP 310 320 330 340 350 360 330 340 350 360 370 380 pF1KE0 KKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLK-QGTEKADTEEMMRE :...: : : . : ::: ::::.:..: :.:.: ::.:.:: .... : .:.. : NP_003 KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE 370 380 390 400 410 420 390 400 410 420 430 440 pF1KE0 AQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVS :..:.:::::::::.::.:.::. ::::::: :::.:.: .:. . .:. ::.:::: NP_003 ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRH-VKDKNIIELVHQVS 430 440 450 460 470 450 460 470 480 490 500 pF1KE0 MGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY ::::::::.:::::::::::::::..:::::::::::::: ::..:: :.. ::::.::: NP_003 MGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY 480 490 500 510 520 530 510 520 530 540 550 560 pF1KE0 APECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPP ::::::. ::::.:::::.:: ::::.:::::::. ::: :: :..:.:.:: :: :: NP_003 APECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPR 540 550 560 570 580 590 570 580 590 600 610 pF1KE0 ELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQKAEAACA :.: ::. :: : :.:: : .:: :.: ::.... NP_003 EMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 600 610 620 630 >>XP_005252204 (OMIM: 600085) PREDICTED: tyrosine-protei (635 aa) initn: 2251 init1: 1046 opt: 1094 Z-score: 429.6 bits: 89.7 E(85289): 3.4e-17 Smith-Waterman score: 2324; 54.4% identity (77.7% similar) in 631 aa overlap (1-602:6-635) 10 20 30 40 50 pF1KE0 MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVR : : : :::::.:.:.: :::..: .::.:::.:::: :::..::..: . XP_005 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 FHHFPIERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVF ::. :::.::::::::::..: .::.::...:.. ::: : :.:: :::.:..:. : : XP_005 AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 DCLRDAMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAER . :.. ..:.::.:::.:.:.::::::::: ::.::::::::::.:::.:....:::.:. XP_005 EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE0 KLYSGAQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQL . :..:.::::.: : ..:.::: :.. : :: :..::.:: :::: :::::::: XP_005 IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL 190 200 210 220 230 240 240 250 260 270 280 pF1KE0 VEYLKLKADGLIYCLKEACPN-SSASNASGAAAPTLP-AHPST------------LTHPQ ::. . :::::. : : . .. .:.. .. : :: .::.: . :. XP_005 VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK 250 260 270 280 290 300 290 300 310 320 pF1KE0 ------------RRIDTLNSDGYTPEPARITSPDKPR--PMPMDTSVYESPYSDPEELKD :. .:.. . : :: : .. :. .:::: ::::::.::::.. XP_005 PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP 310 320 330 340 350 360 330 340 350 360 370 380 pF1KE0 KKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLK-QGTEKADTEEMMRE :...: : : . : ::: ::::.:..: :.:.: ::.:.:: .... : .:.. : XP_005 KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE 370 380 390 400 410 420 390 400 410 420 430 440 pF1KE0 AQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVS :..:.:::::::::.::.:.::. ::::::: :::.:.: .:. . .:. ::.:::: XP_005 ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRH-VKDKNIIELVHQVS 430 440 450 460 470 450 460 470 480 490 500 pF1KE0 MGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY ::::::::.:::::::::::::::..:::::::::::::: ::..:: :.. ::::.::: XP_005 MGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY 480 490 500 510 520 530 510 520 530 540 550 560 pF1KE0 APECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPP ::::::. ::::.:::::.:: ::::.:::::::. ::: :: :..:.:.:: :: :: XP_005 APECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPR 540 550 560 570 580 590 570 580 590 600 610 pF1KE0 ELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQKAEAACA :.: ::. :: : :.:: : .:: :.: ::.... XP_005 EMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 600 610 620 630 619 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 18:03:20 2016 done: Sat Nov 5 18:03:22 2016 Total Scan time: 11.230 Total Display time: 0.160 Function used was FASTA [36.3.4 Apr, 2011]