FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1002, 149 aa 1>>>pF1KE1002 149 - 149 aa - 149 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9972+/-0.000437; mu= 15.2507+/- 0.028 mean_var=120.2659+/-24.334, 0's: 0 Z-trim(114.7): 219 B-trim: 729 in 4/50 Lambda= 0.116951 statistics sampled from 24409 (24720) to 24409 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.657), E-opt: 0.2 (0.29), width: 16 Scan time: 3.980 The best scores are: opt bits E(85289) NP_008819 (OMIM: 114180,614916,616247) calmodulin ( 149) 959 172.1 3e-43 NP_005175 (OMIM: 114183) calmodulin isoform 1 [Hom ( 149) 959 172.1 3e-43 NP_001316851 (OMIM: 114183) calmodulin isoform 1 [ ( 149) 959 172.1 3e-43 NP_001734 (OMIM: 114182,616249) calmodulin isoform ( 149) 959 172.1 3e-43 XP_006720321 (OMIM: 114180,614916,616247) PREDICTE ( 150) 952 170.9 6.8e-43 NP_001292553 (OMIM: 114182,616249) calmodulin isof ( 197) 952 171.1 8e-43 NP_005176 (OMIM: 114184) calmodulin-like protein 3 ( 149) 855 154.5 5.8e-38 NP_001316855 (OMIM: 114183) calmodulin isoform 2 [ ( 113) 735 134.1 6.1e-32 NP_001316853 (OMIM: 114183) calmodulin isoform 2 [ ( 113) 735 134.1 6.1e-32 NP_001316852 (OMIM: 114183) calmodulin isoform 2 [ ( 113) 735 134.1 6.1e-32 NP_001316850 (OMIM: 114183) calmodulin isoform 2 [ ( 113) 735 134.1 6.1e-32 NP_001292555 (OMIM: 114182,616249) calmodulin isof ( 113) 735 134.1 6.1e-32 NP_001292554 (OMIM: 114182,616249) calmodulin isof ( 113) 735 134.1 6.1e-32 NP_001316854 (OMIM: 114183) calmodulin isoform 2 [ ( 113) 735 134.1 6.1e-32 NP_003270 (OMIM: 191039) troponin C, skeletal musc ( 160) 532 100.1 1.5e-21 XP_011527333 (OMIM: 191039) PREDICTED: troponin C, ( 145) 513 96.8 1.3e-20 NP_003271 (OMIM: 191040,611879,613243) troponin C, ( 161) 512 96.7 1.6e-20 NP_004057 (OMIM: 603187) centrin-1 [Homo sapiens] ( 172) 502 95.1 5.3e-20 NP_004335 (OMIM: 300006) centrin-2 [Homo sapiens] ( 172) 496 94.0 1.1e-19 NP_059118 (OMIM: 605183) calmodulin-like protein 5 ( 146) 494 93.6 1.2e-19 NP_619650 (OMIM: 610171) calmodulin-like protein 6 ( 181) 440 84.6 7.7e-17 XP_005244786 (OMIM: 610171) PREDICTED: calmodulin- ( 203) 440 84.7 8.3e-17 NP_001317242 (OMIM: 610171) calmodulin-like protei ( 164) 436 83.9 1.2e-16 NP_524147 (OMIM: 609931) myosin light polypeptide ( 151) 435 83.7 1.2e-16 NP_066299 (OMIM: 609931) myosin light polypeptide ( 151) 428 82.5 2.8e-16 NP_062829 (OMIM: 607315) calcium-binding protein 5 ( 173) 422 81.6 6.2e-16 XP_016882481 (OMIM: 607315) PREDICTED: calcium-bin ( 284) 422 81.9 8.3e-16 NP_004267 (OMIM: 605563) calcium-binding protein 1 ( 167) 418 80.9 9.7e-16 NP_112482 (OMIM: 605563) calcium-binding protein 1 ( 227) 418 81.0 1.2e-15 NP_001028849 (OMIM: 605563) calcium-binding protei ( 370) 418 81.3 1.5e-15 NP_006088 (OMIM: 609905) myosin regulatory light p ( 172) 411 79.7 2.2e-15 NP_001138416 (OMIM: 609211) myosin regulatory ligh ( 172) 407 79.0 3.6e-15 NP_001138417 (OMIM: 609211) myosin regulatory ligh ( 172) 407 79.0 3.6e-15 NP_291024 (OMIM: 609211) myosin regulatory light c ( 172) 407 79.0 3.6e-15 NP_002466 (OMIM: 609930) myosin light chain 6B [Ho ( 208) 406 79.0 4.5e-15 NP_001186558 (OMIM: 609930) myosin light chain 6B ( 208) 406 79.0 4.5e-15 NP_524146 (OMIM: 160780) myosin light chain 1/3, s ( 150) 402 78.1 5.9e-15 NP_057450 (OMIM: 607314,614899) calcium-binding pr ( 220) 403 78.5 6.6e-15 NP_001305425 (OMIM: 607314,614899) calcium-binding ( 226) 403 78.5 6.7e-15 XP_016873514 (OMIM: 608965,610427) PREDICTED: calc ( 170) 398 77.5 1e-14 XP_011543485 (OMIM: 608965,610427) PREDICTED: calc ( 170) 398 77.5 1e-14 NP_001287824 (OMIM: 608965,610427) calcium-binding ( 170) 398 77.5 1e-14 NP_001287825 (OMIM: 608965,610427) calcium-binding ( 170) 398 77.5 1e-14 NP_660201 (OMIM: 608965,610427) calcium-binding pr ( 275) 398 77.8 1.3e-14 XP_011543483 (OMIM: 608965,610427) PREDICTED: calc ( 295) 398 77.8 1.4e-14 NP_524144 (OMIM: 160780) myosin light chain 1/3, s ( 194) 395 77.1 1.6e-14 NP_004356 (OMIM: 602907) centrin-3 isoform 2 [Homo ( 167) 385 75.3 4.6e-14 NP_000249 (OMIM: 160790,608751) myosin light chain ( 195) 382 74.9 7.1e-14 XP_016875728 (OMIM: 605563) PREDICTED: calcium-bin ( 202) 382 74.9 7.3e-14 XP_016875727 (OMIM: 605563) PREDICTED: calcium-bin ( 262) 382 75.1 8.5e-14 >>NP_008819 (OMIM: 114180,614916,616247) calmodulin [Hom (149 aa) initn: 959 init1: 959 opt: 959 Z-score: 897.4 bits: 172.1 E(85289): 3e-43 Smith-Waterman score: 959; 100.0% identity (100.0% similar) in 149 aa overlap (1-149:1-149) 10 20 30 40 50 60 pF1KE1 MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE 70 80 90 100 110 120 130 140 pF1KE1 EVDEMIREADIDGDGQVNYEEFVQMMTAK ::::::::::::::::::::::::::::: NP_008 EVDEMIREADIDGDGQVNYEEFVQMMTAK 130 140 >>NP_005175 (OMIM: 114183) calmodulin isoform 1 [Homo sa (149 aa) initn: 959 init1: 959 opt: 959 Z-score: 897.4 bits: 172.1 E(85289): 3e-43 Smith-Waterman score: 959; 100.0% identity (100.0% similar) in 149 aa overlap (1-149:1-149) 10 20 30 40 50 60 pF1KE1 MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE 70 80 90 100 110 120 130 140 pF1KE1 EVDEMIREADIDGDGQVNYEEFVQMMTAK ::::::::::::::::::::::::::::: NP_005 EVDEMIREADIDGDGQVNYEEFVQMMTAK 130 140 >>NP_001316851 (OMIM: 114183) calmodulin isoform 1 [Homo (149 aa) initn: 959 init1: 959 opt: 959 Z-score: 897.4 bits: 172.1 E(85289): 3e-43 Smith-Waterman score: 959; 100.0% identity (100.0% similar) in 149 aa overlap (1-149:1-149) 10 20 30 40 50 60 pF1KE1 MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE 70 80 90 100 110 120 130 140 pF1KE1 EVDEMIREADIDGDGQVNYEEFVQMMTAK ::::::::::::::::::::::::::::: NP_001 EVDEMIREADIDGDGQVNYEEFVQMMTAK 130 140 >>NP_001734 (OMIM: 114182,616249) calmodulin isoform 2 [ (149 aa) initn: 959 init1: 959 opt: 959 Z-score: 897.4 bits: 172.1 E(85289): 3e-43 Smith-Waterman score: 959; 100.0% identity (100.0% similar) in 149 aa overlap (1-149:1-149) 10 20 30 40 50 60 pF1KE1 MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE 70 80 90 100 110 120 130 140 pF1KE1 EVDEMIREADIDGDGQVNYEEFVQMMTAK ::::::::::::::::::::::::::::: NP_001 EVDEMIREADIDGDGQVNYEEFVQMMTAK 130 140 >>XP_006720321 (OMIM: 114180,614916,616247) PREDICTED: c (150 aa) initn: 952 init1: 952 opt: 952 Z-score: 891.0 bits: 170.9 E(85289): 6.8e-43 Smith-Waterman score: 952; 100.0% identity (100.0% similar) in 148 aa overlap (2-149:3-150) 10 20 30 40 50 pF1KE1 MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MQADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDAD 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 GNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTD 70 80 90 100 110 120 120 130 140 pF1KE1 EEVDEMIREADIDGDGQVNYEEFVQMMTAK :::::::::::::::::::::::::::::: XP_006 EEVDEMIREADIDGDGQVNYEEFVQMMTAK 130 140 150 >>NP_001292553 (OMIM: 114182,616249) calmodulin isoform (197 aa) initn: 952 init1: 952 opt: 952 Z-score: 889.8 bits: 171.1 E(85289): 8e-43 Smith-Waterman score: 952; 100.0% identity (100.0% similar) in 148 aa overlap (2-149:50-197) 10 20 30 pF1KE1 MADQLTEEQIAEFKEAFSLFDKDGDGTITTK :::::::::::::::::::::::::::::: NP_001 GCVVASRKPVALAAWLALYIASHFAQQPCKADQLTEEQIAEFKEAFSLFDKDGDGTITTK 20 30 40 50 60 70 40 50 60 70 80 90 pF1KE1 ELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFR 80 90 100 110 120 130 100 110 120 130 140 pF1KE1 VFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK 140 150 160 170 180 190 >>NP_005176 (OMIM: 114184) calmodulin-like protein 3 [Ho (149 aa) initn: 1059 init1: 855 opt: 855 Z-score: 802.6 bits: 154.5 E(85289): 5.8e-38 Smith-Waterman score: 855; 84.6% identity (96.0% similar) in 149 aa overlap (1-149:1-149) 10 20 30 40 50 60 pF1KE1 MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG :::::::::..::::::::::::::: :::.::::::::::::::::::.::..:.: :: NP_005 MADQLTEEQVTEFKEAFSLFDKDGDGCITTRELGTVMRSLGQNPTEAELRDMMSEIDRDG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE :::.:::::: ::::::::::.:::::::::::::::::..:::::::::: :::::.:: NP_005 NGTVDFPEFLGMMARKMKDTDNEEEIREAFRVFDKDGNGFVSAAELRHVMTRLGEKLSDE 70 80 90 100 110 120 130 140 pF1KE1 EVDEMIREADIDGDGQVNYEEFVQMMTAK ::::::: :: ::::::::::::.....: NP_005 EVDEMIRAADTDGDGQVNYEEFVRVLVSK 130 140 >>NP_001316855 (OMIM: 114183) calmodulin isoform 2 [Homo (113 aa) initn: 735 init1: 735 opt: 735 Z-score: 694.4 bits: 134.1 E(85289): 6.1e-32 Smith-Waterman score: 735; 100.0% identity (100.0% similar) in 113 aa overlap (37-149:1-113) 10 20 30 40 50 60 pF1KE1 EEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDF :::::::::::::::::::::::::::::: NP_001 MRSLGQNPTEAELQDMINEVDADGNGTIDF 10 20 30 70 80 90 100 110 120 pF1KE1 PEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMI 40 50 60 70 80 90 130 140 pF1KE1 READIDGDGQVNYEEFVQMMTAK ::::::::::::::::::::::: NP_001 READIDGDGQVNYEEFVQMMTAK 100 110 >>NP_001316853 (OMIM: 114183) calmodulin isoform 2 [Homo (113 aa) initn: 735 init1: 735 opt: 735 Z-score: 694.4 bits: 134.1 E(85289): 6.1e-32 Smith-Waterman score: 735; 100.0% identity (100.0% similar) in 113 aa overlap (37-149:1-113) 10 20 30 40 50 60 pF1KE1 EEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDF :::::::::::::::::::::::::::::: NP_001 MRSLGQNPTEAELQDMINEVDADGNGTIDF 10 20 30 70 80 90 100 110 120 pF1KE1 PEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMI 40 50 60 70 80 90 130 140 pF1KE1 READIDGDGQVNYEEFVQMMTAK ::::::::::::::::::::::: NP_001 READIDGDGQVNYEEFVQMMTAK 100 110 >>NP_001316852 (OMIM: 114183) calmodulin isoform 2 [Homo (113 aa) initn: 735 init1: 735 opt: 735 Z-score: 694.4 bits: 134.1 E(85289): 6.1e-32 Smith-Waterman score: 735; 100.0% identity (100.0% similar) in 113 aa overlap (37-149:1-113) 10 20 30 40 50 60 pF1KE1 EEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDF :::::::::::::::::::::::::::::: NP_001 MRSLGQNPTEAELQDMINEVDADGNGTIDF 10 20 30 70 80 90 100 110 120 pF1KE1 PEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMI 40 50 60 70 80 90 130 140 pF1KE1 READIDGDGQVNYEEFVQMMTAK ::::::::::::::::::::::: NP_001 READIDGDGQVNYEEFVQMMTAK 100 110 149 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 13:20:08 2016 done: Sat Nov 5 13:20:09 2016 Total Scan time: 3.980 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]