Result of FASTA (ccds) for
pF1KE1014
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1014, 302 aa
1>>>pF1KE1014 302 - 302 aa - 302 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.3488+/-0.000904; mu= 15.1178+/- 0.054
mean_var=77.3265+/-15.578, 0's: 0 Z-trim(105.7): 77 B-trim: 41 in 2/50
Lambda= 0.145851
statistics sampled from 8477 (8560) to 8477 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.635), E-opt: 0.2 (0.263), width: 16
Scan time: 2.410
The best scores are: opt bits E(32554)
CCDS42952.1 ICOSLG gene_id:23308|Hs108|chr21 ( 302) 2005 431.5 3.7e-121
CCDS63379.1 ICOSLG gene_id:23308|Hs108|chr21 ( 309) 1982 426.7 1.1e-119
CCDS63377.1 ICOSLG gene_id:23308|Hs108|chr21 ( 185) 1124 246.0 1.6e-65
CCDS10251.1 CD276 gene_id:80381|Hs108|chr15 ( 316) 340 81.2 1.1e-15
CCDS32288.1 CD276 gene_id:80381|Hs108|chr15 ( 534) 322 77.6 2.3e-14
>>CCDS42952.1 ICOSLG gene_id:23308|Hs108|chr21 (302 aa)
initn: 2005 init1: 2005 opt: 2005 Z-score: 2288.6 bits: 431.5 E(32554): 3.7e-121
Smith-Waterman score: 2005; 100.0% identity (100.0% similar) in 302 aa overlap (1-302:1-302)
10 20 30 40 50 60
pF1KE1 MRLGSPGLLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 MRLGSPGLLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 TVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 TVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 GFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 GFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 DQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 DQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 KITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQHSYAGAWAVSPETELTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 KITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQHSYAGAWAVSPETELTG
250 260 270 280 290 300
pF1KE1 HV
::
CCDS42 HV
>>CCDS63379.1 ICOSLG gene_id:23308|Hs108|chr21 (309 aa)
initn: 1982 init1: 1982 opt: 1982 Z-score: 2262.3 bits: 426.7 E(32554): 1.1e-119
Smith-Waterman score: 1982; 100.0% identity (100.0% similar) in 299 aa overlap (1-299:1-299)
10 20 30 40 50 60
pF1KE1 MRLGSPGLLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS63 MRLGSPGLLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 TVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS63 TVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 GFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS63 GFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 DQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS63 DQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 KITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQHSYAGAWAVSPETELTG
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS63 KITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQHSYAGAWAVSPETELTE
250 260 270 280 290 300
pF1KE1 HV
CCDS63 SWNLLLLLS
>>CCDS63377.1 ICOSLG gene_id:23308|Hs108|chr21 (185 aa)
initn: 1124 init1: 1124 opt: 1124 Z-score: 1289.7 bits: 246.0 E(32554): 1.6e-65
Smith-Waterman score: 1124; 100.0% identity (100.0% similar) in 168 aa overlap (135-302:18-185)
110 120 130 140 150 160
pF1KE1 PQDEQKFHCLVLSQSLGFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGY
::::::::::::::::::::::::::::::
CCDS63 MRLGSPGLLFLLFSSLRAANFSVPVVSAPHSPSQDELTFTCTSINGY
10 20 30 40
170 180 190 200 210 220
pF1KE1 PRPNVYWINKTDNSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS63 PRPNVYWINKTDNSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQ
50 60 70 80 90 100
230 240 250 260 270 280
pF1KE1 NLTVGSQTGNDIGERDKITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS63 NLTVGSQTGNDIGERDKITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQH
110 120 130 140 150 160
290 300
pF1KE1 SYAGAWAVSPETELTGHV
::::::::::::::::::
CCDS63 SYAGAWAVSPETELTGHV
170 180
>>CCDS10251.1 CD276 gene_id:80381|Hs108|chr15 (316 aa)
initn: 251 init1: 83 opt: 340 Z-score: 394.9 bits: 81.2 E(32554): 1.1e-15
Smith-Waterman score: 367; 30.5% identity (56.5% similar) in 308 aa overlap (2-289:4-285)
10 20 30 40
pF1KE1 MRLGSPG-----------LLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSRFDL
: :::: : : : ..:.... : : :.::.:. : :. :.:
CCDS10 MLRRRGSPGMGVHVGAALGALWFCLTGALEVQVPEDPVVALVGTDATLCCSFSPEPGFSL
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE1 NDVYVYWQTSESKTVVTYHIPQNSSLENVD--SRYRNRALMSPAGMLRGDFSLRLFNVTP
.. . :: ...: .: .: :. : : : ::. . : . .:. :::: :
CCDS10 AQLNLIWQLTDTKQLV------HSFAEGQDQGSAYANRTALFPDLLAQGNASLRLQRVRV
70 80 90 100 110
110 120 130 140 150 160
pF1KE1 QDEQKFHCLVLSQSLGFQEVLSVEVTLHVAANFSVPVVS-APHSPSQ--DELTFTCTSIN
:: .: :.: ...: :. :.:.::: .: : .. :.. . : .:.::.:
CCDS10 ADEGSFTCFVSIRDFG-----SAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVTITCSSYR
120 130 140 150 160
170 180 190 200 210 220
pF1KE1 GYPRPNVYWINKTDNSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLL
:::. .:.: . : .. .. . : .::.:: ::::.. . . .: ..: .:
CCDS10 GYPEAEVFWQDGQGVPLTGNVTTSQMA--NEQGLFDVHSVLRVVLGANGTYSCLVRNPVL
170 180 190 200 210 220
230 240 250 260 270
pF1KE1 QQNLTVGSQTGNDIGERDKITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVC----R
::. :: : :: .:.. . : : ... :... ::...:: .
CCDS10 QQDAH-GSVT---------ITGQPMTFPPE--ALWVTVGLSVCLIALLVALAFVCWRKIK
230 240 250 260 270
280 290 300
pF1KE1 DRCLQHSYAGAWAVSPETELTGHV
. : ... :::
CCDS10 QSCEEEN-AGAEDQDGEGEGSKTALQPLKHSDSKEDDGQEIA
280 290 300 310
>>CCDS32288.1 CD276 gene_id:80381|Hs108|chr15 (534 aa)
initn: 275 init1: 83 opt: 322 Z-score: 371.2 bits: 77.6 E(32554): 2.3e-14
Smith-Waterman score: 349; 29.9% identity (58.5% similar) in 284 aa overlap (15-289:246-503)
10 20 30 40
pF1KE1 MRLGSPGLLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSR
...... : : :.::.:. : :.
CCDS32 GTYSCLVRNPVLQQDAHSSVTITPQRSPTGAVEVQVPEDPVVALVGTDATLRCSFSPEPG
220 230 240 250 260 270
50 60 70 80 90 100
pF1KE1 FDLNDVYVYWQTSESKTVVTYHIPQNSSLENVD--SRYRNRALMSPAGMLRGDFSLRLFN
:.: .. . :: ...: .: .: :. : : : ::. . : . .:. ::::
CCDS32 FSLAQLNLIWQLTDTKQLV------HSFTEGRDQGSAYANRTALFPDLLAQGNASLRLQR
280 290 300 310 320
110 120 130 140 150
pF1KE1 VTPQDEQKFHCLVLSQSLGFQEVLSVEVTLHVAANFSVPVVS-APHSPSQ--DELTFTCT
: :: .: :.: ...: :. :.:.::: .: : .. :.. . : .:.::.
CCDS32 VRVADEGSFTCFVSIRDFG-----SAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVTITCS
330 340 350 360 370 380
160 170 180 190 200 210
pF1KE1 SINGYPRPNVYWINKTDNSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIEN
: :::. .:.: . : .. .. . : .::.:: ::::.. . . .: ..:
CCDS32 SYRGYPEAEVFWQDGQGVPLTGNVTTSQMA--NEQGLFDVHSVLRVVLGANGTYSCLVRN
390 400 410 420 430 440
220 230 240 250 260 270
pF1KE1 VLLQQNLTVGSQTGNDIGERDKITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVC--
.:::. . :: : :: .:.. . : : ... :... ::...::
CCDS32 PVLQQD-AHGSVT---------ITGQPMTFPPE--ALWVTVGLSVCLIALLVALAFVCWR
450 460 470 480 490
280 290 300
pF1KE1 --RDRCLQHSYAGAWAVSPETELTGHV
.. : ... :::
CCDS32 KIKQSCEEEN-AGAEDQDGEGEGSKTALQPLKHSDSKEDDGQEIA
500 510 520 530
>--
initn: 230 init1: 82 opt: 340 Z-score: 391.7 bits: 81.4 E(32554): 1.7e-15
Smith-Waterman score: 340; 32.4% identity (59.3% similar) in 241 aa overlap (2-225:4-230)
10 20 30 40
pF1KE1 MRLGSPG-----------LLFLLFSSLRADTQEKEVRAMVGSDVELSCA-CPEGSRFD
: :::: : : : ..:.... : : :.::.:. : :. :: . :.
CCDS32 MLRRRGSPGMGVHVGAALGALWFCLTGALEVQVPEDPVVALVGTDATLCCSFSPEPG-FS
10 20 30 40 50
50 60 70 80 90 100
pF1KE1 LNDVYVYWQTSESKTVVTYHIPQNSSLENVD--SRYRNRALMSPAGMLRGDFSLRLFNVT
: .. . :: ...: .: .: :. : : : ::. . : . .:. :::: :
CCDS32 LAQLNLIWQLTDTKQLV------HSFAEGQDQGSAYANRTALFPDLLAQGNASLRLQRVR
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE1 PQDEQKFHCLVLSQSLGFQEVLSVEVTLHVAANFSVPVVS-APHSPSQ--DELTFTCTSI
:: .: :.: ...: :. :.:.::: .: : .. :.. . : .:.::.:
CCDS32 VADEGSFTCFVSIRDFG-----SAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVTITCSSY
120 130 140 150 160
170 180 190 200 210 220
pF1KE1 NGYPRPNVYWINKTDNSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVL
.:::. .:.: . : .. .. . : .::.:: :.::.. . . .: ..: .
CCDS32 QGYPEAEVFWQDGQGVPLTGNVTTSQMA--NEQGLFDVHSILRVVLGANGTYSCLVRNPV
170 180 190 200 210 220
230 240 250 260 270 280
pF1KE1 LQQNLTVGSQTGNDIGERDKITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRC
:::.
CCDS32 LQQDAHSSVTITPQRSPTGAVEVQVPEDPVVALVGTDATLRCSFSPEPGFSLAQLNLIWQ
230 240 250 260 270 280
302 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 13:24:32 2016 done: Sat Nov 5 13:24:33 2016
Total Scan time: 2.410 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]