FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1020, 668 aa 1>>>pF1KE1020 668 - 668 aa - 668 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.2649+/-0.000858; mu= 3.6564+/- 0.052 mean_var=244.8178+/-49.258, 0's: 0 Z-trim(116.2): 8 B-trim: 278 in 1/53 Lambda= 0.081970 statistics sampled from 16845 (16850) to 16845 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.806), E-opt: 0.2 (0.518), width: 16 Scan time: 4.810 The best scores are: opt bits E(32554) CCDS1103.1 FAM189B gene_id:10712|Hs108|chr1 ( 668) 4620 559.3 6.1e-159 CCDS58035.1 FAM189B gene_id:10712|Hs108|chr1 ( 650) 4009 487.1 3.4e-137 CCDS1104.1 FAM189B gene_id:10712|Hs108|chr1 ( 572) 3486 425.2 1.3e-118 CCDS45198.1 FAM189A1 gene_id:23359|Hs108|chr15 ( 539) 820 109.9 9.8e-24 >>CCDS1103.1 FAM189B gene_id:10712|Hs108|chr1 (668 aa) initn: 4620 init1: 4620 opt: 4620 Z-score: 2967.0 bits: 559.3 E(32554): 6.1e-159 Smith-Waterman score: 4620; 99.9% identity (99.9% similar) in 668 aa overlap (1-668:1-668) 10 20 30 40 50 60 pF1KE1 MMPSPSDSSRSLTSRPSTRGLTHLRLHRPWLQALLTLGLVQVLLGILVVTFSMVASSVTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 MMPSPSDSSRSLTSRPSTRGLTHLRLHRPWLQALLTLGLVQVLLGILVVTFSMVASSVTT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 TESIKRSCPSWAGFSLAFSGVVGIVSWKRPFTLVISFFSLLSVLCVMLSMAGSVLSCKNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 TESIKRSCPSWAGFSLAFSGVVGIVSWKRPFTLVISFFSLLSVLCVMLSMAGSVLSCKNA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 QLARDFQQCSLEGKVCVCCPSVPLLRPCPESGQELKVAPNSTCDEARGALKNLLFSVCGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 QLARDFQQCSLEGKVCVCCPSVPLLRPCPESGQELKVAPNSTCDEARGALKNLLFSVCGL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 TICAAIICTLPAIVCCIQIFSLDLVHTLAPERSVSGPLGPLGCTSPPPAPLLHTMLDLEE :::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 TICAAIICTLSAIVCCIQIFSLDLVHTLAPERSVSGPLGPLGCTSPPPAPLLHTMLDLEE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 FVPPVPPPPYYPPEYTCSSETDAQSITYNGSMDSPVPLYPTDCPPSYEAVMGLRGDSQAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 FVPPVPPPPYYPPEYTCSSETDAQSITYNGSMDSPVPLYPTDCPPSYEAVMGLRGDSQAT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 LFDPQLHDGSCICERVASIVDVSMDSGSLVLSAIGDLPGGSSPSEDSCLLELQGSVRSVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 LFDPQLHDGSCICERVASIVDVSMDSGSLVLSAIGDLPGGSSPSEDSCLLELQGSVRSVD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 YVLFRSIQRSRAGYCLSLDCGLRGPFEESPLPRRPPRAARSYSCSAPEAPPPLGAPTAAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 YVLFRSIQRSRAGYCLSLDCGLRGPFEESPLPRRPPRAARSYSCSAPEAPPPLGAPTAAR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 SCHRLEGWPPWVGPCFPELRRRVPRGGGRPAAAPPTRAPTRRFSDSSGSLTPPGHRPPHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 SCHRLEGWPPWVGPCFPELRRRVPRGGGRPAAAPPTRAPTRRFSDSSGSLTPPGHRPPHP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE1 ASPPPLLLPRSHSDPGITTSSDTADFRDLYTKVLEEEAASVSSADTGLCSEACLFRLARC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 ASPPPLLLPRSHSDPGITTSSDTADFRDLYTKVLEEEAASVSSADTGLCSEACLFRLARC 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE1 PSPKLLRARSAEKRRPVPTFQKVPLPSGPAPAHSLGDLKGSWPGRGLVTRFLQISRKAPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 PSPKLLRARSAEKRRPVPTFQKVPLPSGPAPAHSLGDLKGSWPGRGLVTRFLQISRKAPD 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE1 PSGTGAHGHKQVPRSLWGRPGRESLHLRSCGDLSSSSSLRRLLSGRRLERGTRPHSLSLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 PSGTGAHGHKQVPRSLWGRPGRESLHLRSCGDLSSSSSLRRLLSGRRLERGTRPHSLSLN 610 620 630 640 650 660 pF1KE1 GGSRETGL :::::::: CCDS11 GGSRETGL >>CCDS58035.1 FAM189B gene_id:10712|Hs108|chr1 (650 aa) initn: 3730 init1: 3246 opt: 4009 Z-score: 2576.7 bits: 487.1 E(32554): 3.4e-137 Smith-Waterman score: 4435; 96.9% identity (96.9% similar) in 669 aa overlap (1-668:1-650) 10 20 30 40 50 60 pF1KE1 MMPSPSDSSRSLTSRPSTRGLTHLRLHRPWLQALLTLGLVQVLLGILVVTFSMVASSVTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 MMPSPSDSSRSLTSRPSTRGLTHLRLHRPWLQALLTLGLVQVLLGILVVTFSMVASSVTT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 TESIKRSCPSWAGFSLAFSGVVGIVSWKRPFTLVISFFSLLSVLCVMLSMAGSVLSCKNA ::::::::::::::: :::::::::::::::::::::::::: CCDS58 TESIKRSCPSWAGFS-------------------ISFFSLLSVLCVMLSMAGSVLSCKNA 70 80 90 100 130 140 150 160 170 180 pF1KE1 QLARDFQQCSLEGKVCVCCPSVPLLRPCPESGQELKVAPNSTCDEARGALKNLLFSVCGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 QLARDFQQCSLEGKVCVCCPSVPLLRPCPESGQELKVAPNSTCDEARGALKNLLFSVCGL 110 120 130 140 150 160 190 200 210 220 230 pF1KE1 TICAAIICTLPAIVCCIQIFSLDLVHT-LAPERSVSGPLGPLGCTSPPPAPLLHTMLDLE :::::::::: :::::::::::::::: :::::::::::::::::::::::::::::::: CCDS58 TICAAIICTLSAIVCCIQIFSLDLVHTQLAPERSVSGPLGPLGCTSPPPAPLLHTMLDLE 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE1 EFVPPVPPPPYYPPEYTCSSETDAQSITYNGSMDSPVPLYPTDCPPSYEAVMGLRGDSQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 EFVPPVPPPPYYPPEYTCSSETDAQSITYNGSMDSPVPLYPTDCPPSYEAVMGLRGDSQA 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE1 TLFDPQLHDGSCICERVASIVDVSMDSGSLVLSAIGDLPGGSSPSEDSCLLELQGSVRSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 TLFDPQLHDGSCICERVASIVDVSMDSGSLVLSAIGDLPGGSSPSEDSCLLELQGSVRSV 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE1 DYVLFRSIQRSRAGYCLSLDCGLRGPFEESPLPRRPPRAARSYSCSAPEAPPPLGAPTAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 DYVLFRSIQRSRAGYCLSLDCGLRGPFEESPLPRRPPRAARSYSCSAPEAPPPLGAPTAA 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE1 RSCHRLEGWPPWVGPCFPELRRRVPRGGGRPAAAPPTRAPTRRFSDSSGSLTPPGHRPPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 RSCHRLEGWPPWVGPCFPELRRRVPRGGGRPAAAPPTRAPTRRFSDSSGSLTPPGHRPPH 410 420 430 440 450 460 480 490 500 510 520 530 pF1KE1 PASPPPLLLPRSHSDPGITTSSDTADFRDLYTKVLEEEAASVSSADTGLCSEACLFRLAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 PASPPPLLLPRSHSDPGITTSSDTADFRDLYTKVLEEEAASVSSADTGLCSEACLFRLAR 470 480 490 500 510 520 540 550 560 570 580 590 pF1KE1 CPSPKLLRARSAEKRRPVPTFQKVPLPSGPAPAHSLGDLKGSWPGRGLVTRFLQISRKAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 CPSPKLLRARSAEKRRPVPTFQKVPLPSGPAPAHSLGDLKGSWPGRGLVTRFLQISRKAP 530 540 550 560 570 580 600 610 620 630 640 650 pF1KE1 DPSGTGAHGHKQVPRSLWGRPGRESLHLRSCGDLSSSSSLRRLLSGRRLERGTRPHSLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 DPSGTGAHGHKQVPRSLWGRPGRESLHLRSCGDLSSSSSLRRLLSGRRLERGTRPHSLSL 590 600 610 620 630 640 660 pF1KE1 NGGSRETGL ::::::::: CCDS58 NGGSRETGL 650 >>CCDS1104.1 FAM189B gene_id:10712|Hs108|chr1 (572 aa) initn: 3482 init1: 3482 opt: 3486 Z-score: 2243.2 bits: 425.2 E(32554): 1.3e-118 Smith-Waterman score: 3762; 85.5% identity (85.5% similar) in 668 aa overlap (1-668:1-572) 10 20 30 40 50 60 pF1KE1 MMPSPSDSSRSLTSRPSTRGLTHLRLHRPWLQALLTLGLVQVLLGILVVTFSMVASSVTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 MMPSPSDSSRSLTSRPSTRGLTHLRLHRPWLQALLTLGLVQVLLGILVVTFSMVASSVTT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 TESIKRSCPSWAGFSLAFSGVVGIVSWKRPFTLVISFFSLLSVLCVMLSMAGSVLSCKNA ::::::::::::::: CCDS11 TESIKRSCPSWAGFS--------------------------------------------- 70 130 140 150 160 170 180 pF1KE1 QLARDFQQCSLEGKVCVCCPSVPLLRPCPESGQELKVAPNSTCDEARGALKNLLFSVCGL ::::::::: CCDS11 ---------------------------------------------------NLLFSVCGL 80 190 200 210 220 230 240 pF1KE1 TICAAIICTLPAIVCCIQIFSLDLVHTLAPERSVSGPLGPLGCTSPPPAPLLHTMLDLEE :::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 TICAAIICTLSAIVCCIQIFSLDLVHTLAPERSVSGPLGPLGCTSPPPAPLLHTMLDLEE 90 100 110 120 130 140 250 260 270 280 290 300 pF1KE1 FVPPVPPPPYYPPEYTCSSETDAQSITYNGSMDSPVPLYPTDCPPSYEAVMGLRGDSQAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 FVPPVPPPPYYPPEYTCSSETDAQSITYNGSMDSPVPLYPTDCPPSYEAVMGLRGDSQAT 150 160 170 180 190 200 310 320 330 340 350 360 pF1KE1 LFDPQLHDGSCICERVASIVDVSMDSGSLVLSAIGDLPGGSSPSEDSCLLELQGSVRSVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 LFDPQLHDGSCICERVASIVDVSMDSGSLVLSAIGDLPGGSSPSEDSCLLELQGSVRSVD 210 220 230 240 250 260 370 380 390 400 410 420 pF1KE1 YVLFRSIQRSRAGYCLSLDCGLRGPFEESPLPRRPPRAARSYSCSAPEAPPPLGAPTAAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 YVLFRSIQRSRAGYCLSLDCGLRGPFEESPLPRRPPRAARSYSCSAPEAPPPLGAPTAAR 270 280 290 300 310 320 430 440 450 460 470 480 pF1KE1 SCHRLEGWPPWVGPCFPELRRRVPRGGGRPAAAPPTRAPTRRFSDSSGSLTPPGHRPPHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 SCHRLEGWPPWVGPCFPELRRRVPRGGGRPAAAPPTRAPTRRFSDSSGSLTPPGHRPPHP 330 340 350 360 370 380 490 500 510 520 530 540 pF1KE1 ASPPPLLLPRSHSDPGITTSSDTADFRDLYTKVLEEEAASVSSADTGLCSEACLFRLARC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 ASPPPLLLPRSHSDPGITTSSDTADFRDLYTKVLEEEAASVSSADTGLCSEACLFRLARC 390 400 410 420 430 440 550 560 570 580 590 600 pF1KE1 PSPKLLRARSAEKRRPVPTFQKVPLPSGPAPAHSLGDLKGSWPGRGLVTRFLQISRKAPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 PSPKLLRARSAEKRRPVPTFQKVPLPSGPAPAHSLGDLKGSWPGRGLVTRFLQISRKAPD 450 460 470 480 490 500 610 620 630 640 650 660 pF1KE1 PSGTGAHGHKQVPRSLWGRPGRESLHLRSCGDLSSSSSLRRLLSGRRLERGTRPHSLSLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 PSGTGAHGHKQVPRSLWGRPGRESLHLRSCGDLSSSSSLRRLLSGRRLERGTRPHSLSLN 510 520 530 540 550 560 pF1KE1 GGSRETGL :::::::: CCDS11 GGSRETGL 570 >>CCDS45198.1 FAM189A1 gene_id:23359|Hs108|chr15 (539 aa) initn: 966 init1: 390 opt: 820 Z-score: 539.6 bits: 109.9 E(32554): 9.8e-24 Smith-Waterman score: 927; 36.0% identity (59.3% similar) in 541 aa overlap (2-515:1-498) 10 20 30 40 50 pF1KE1 MMPSPSDSSRSLTSRPST--RGLTHLRLHRPWLQALLTLGLVQVLLGILVVTFSMVASSV :: :. . :. ::.. :.:..:: . .:.:: .:. :: :.:. :..: .. CCDS45 MP-PAGGPRA--PRPAALPRSLSRLRECPGRSRIVLALGATQMALGCLIVAVSFAALAL 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 TTTESIKRSCPSWAGFSLAFSGVVGIVSWKRPFTLVISFFSLLSVLCVMLSMAGSVLSCK ::. ...::: :::::. .::..:.::::::..:::.:: :::..::::..:::.:::. CCDS45 TTSARVRHSCPFWAGFSVLLSGLIGVVSWKRPLSLVITFFMLLSAVCVMLNLAGSILSCQ 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 NAQLARDFQQCSL----EGKVCVCCPSVPLLRPCPESGQELKVAP-NSTCDEARGALKNL ::::. ... :.: .::::: : . :. ::. : . .:. .: .::.: CCDS45 NAQLVNSLEGCQLIKFDSVEVCVCCELQHQSSGCSNLGETLKLNPLQENCNAVRLTLKDL 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 LFSVCGLTICAAIICTLPAIVCCIQIFSLDLVHTLAPERSVSGPLGPLGCTSPPPAPLLH :::::.:.. ..:.:.: . .::.:. : :... . :.:: : .: :..: . .:: CCDS45 LFSVCALNVLSTIVCALATAMCCMQMVSSDVLQMFLPQRS--HPANPT-CVTPH-GTVLH 180 190 200 210 220 230 240 250 260 270 280 pF1KE1 TMLDLEEFVPPVPPPPYYPPEYTCSSETDAQ------------SITYNGSMDSPVPLYPT ::..::.::.::::::::::::. :.:: . :. ...:: :::. CCDS45 QTLDFDEFIPPLPPPPYYPPEYTCTPSTEAQRGLHLDFAPSPFGTLYDVAINSPGLLYPA 240 250 260 270 280 290 290 300 310 320 330 pF1KE1 DCPPSYEAVMGLRGDSQATLFDPQLHDGSCICERVAS--IVDVSMDSGSLVLSAIGDLPG . :: ::::.: ::.: . :. ..: ... . : :: ::..: : CCDS45 ELPPPYEAVVGQPPASQVTSIGQQVAESSSGDPNTSAGFSTPVPADSTSLLVSE-GTATP 300 310 320 330 340 350 340 350 360 370 380 390 pF1KE1 GSSPSEDSCLLELQGSVRSVDYVLFRSIQRSRAGYCLSLDCGLRGPFEESPLPRRPPRAA ::::: :. . :. . .: :. : :. . . : : : :.. CCDS45 GSSPSPDGPV----GAPAPSEPAL-------PPGHVSPEDPGMGSQVQ--PGPGRVSRST 360 370 380 390 400 410 420 430 440 450 pF1KE1 RSYS-CSAPEAPPPLGAPTAAR-SCHR-LEGWPPWVGPCFPELRRRVP---RGGGRPAAA . . :.. : : .. : :: . ::. . : . : . :. ::. CCDS45 SDPTLCTSSMA----GDASSHRPSCSQDLEAGLSEAVPGSASMSRSATAACRAQLSPAGD 400 410 420 430 440 450 460 470 480 490 500 510 pF1KE1 PPTRAPTRRFSDSSGSLTPPGHRPPHPASPPPLLLPRSHSDPGITTSSDTADFRDLYTKV : : .: :: : ::. ::: : :. :: : : .: CCDS45 PDTWKTDQRP-------TPE----PFPATSKE--RPRSLVD-----SKAYADARVLVAKF 460 470 480 490 520 530 540 550 560 570 pF1KE1 LEEEAASVSSADTGLCSEACLFRLARCPSPKLLRARSAEKRRPVPTFQKVPLPSGPAPAH :: CCDS45 LEHSHCALPTEAQHMVGAMRLAVTNEERLEEEAVFGADVLDQV 500 510 520 530 668 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 21:06:48 2016 done: Sat Nov 5 21:06:48 2016 Total Scan time: 4.810 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]