FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1026, 979 aa 1>>>pF1KE1026 979 - 979 aa - 979 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 17.1524+/-0.000566; mu= -31.7690+/- 0.036 mean_var=832.9317+/-169.272, 0's: 0 Z-trim(124.1): 38 B-trim: 0 in 0/59 Lambda= 0.044440 statistics sampled from 44978 (45028) to 44978 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.767), E-opt: 0.2 (0.528), width: 16 Scan time: 16.820 The best scores are: opt bits E(85289) NP_002909 (OMIM: 600006) MHC class II regulatory f ( 979) 6473 431.1 1.4e-119 XP_011526471 (OMIM: 600006) PREDICTED: MHC class I ( 980) 4695 317.1 2.9e-85 XP_011526472 (OMIM: 600006) PREDICTED: MHC class I ( 980) 4695 317.1 2.9e-85 XP_011526467 (OMIM: 600006) PREDICTED: MHC class I (1089) 4695 317.1 3.1e-85 XP_011526468 (OMIM: 600006) PREDICTED: MHC class I (1089) 4695 317.1 3.1e-85 XP_011526469 (OMIM: 600006) PREDICTED: MHC class I (1089) 4695 317.1 3.1e-85 XP_011526470 (OMIM: 600006) PREDICTED: MHC class I ( 991) 3749 256.5 5.2e-67 XP_016870490 (OMIM: 601337) PREDICTED: transcripti ( 724) 2484 175.2 1.1e-42 NP_001269045 (OMIM: 601337) transcription factor R ( 749) 2439 172.4 8.1e-42 NP_602304 (OMIM: 601337) transcription factor RFX3 ( 749) 2439 172.4 8.1e-42 XP_011516302 (OMIM: 601337) PREDICTED: transcripti ( 745) 2426 171.5 1.4e-41 XP_006716903 (OMIM: 601337) PREDICTED: transcripti ( 780) 2383 168.8 1e-40 XP_011516301 (OMIM: 601337) PREDICTED: transcripti ( 770) 2381 168.7 1.1e-40 XP_006716907 (OMIM: 601337) PREDICTED: transcripti ( 770) 2381 168.7 1.1e-40 XP_006716908 (OMIM: 601337) PREDICTED: transcripti ( 770) 2381 168.7 1.1e-40 XP_016870489 (OMIM: 601337) PREDICTED: transcripti ( 770) 2381 168.7 1.1e-40 XP_006716906 (OMIM: 601337) PREDICTED: transcripti ( 770) 2381 168.7 1.1e-40 XP_011516300 (OMIM: 601337) PREDICTED: transcripti ( 770) 2381 168.7 1.1e-40 NP_002910 (OMIM: 601337) transcription factor RFX3 ( 707) 2378 168.4 1.2e-40 XP_011516303 (OMIM: 601337) PREDICTED: transcripti ( 687) 2342 166.1 5.6e-40 XP_016882597 (OMIM: 142765) PREDICTED: DNA-binding ( 653) 2297 163.2 4e-39 NP_602309 (OMIM: 142765) DNA-binding protein RFX2 ( 698) 2297 163.2 4.2e-39 XP_011526473 (OMIM: 142765) PREDICTED: DNA-binding ( 723) 2263 161.1 2e-38 NP_000626 (OMIM: 142765) DNA-binding protein RFX2 ( 723) 2263 161.1 2e-38 XP_011526474 (OMIM: 142765) PREDICTED: DNA-binding ( 687) 2247 160.0 3.8e-38 XP_016882596 (OMIM: 142765) PREDICTED: DNA-binding ( 678) 2238 159.4 5.7e-38 XP_006716910 (OMIM: 601337) PREDICTED: transcripti ( 492) 1742 127.5 1.7e-28 XP_016870491 (OMIM: 601337) PREDICTED: transcripti ( 501) 1736 127.2 2.2e-28 NP_001269046 (OMIM: 601337) transcription factor R ( 413) 1037 82.3 5.9e-15 NP_115880 (OMIM: 603958) transcription factor RFX4 ( 641) 568 52.4 9.3e-06 >>NP_002909 (OMIM: 600006) MHC class II regulatory facto (979 aa) initn: 6473 init1: 6473 opt: 6473 Z-score: 2267.9 bits: 431.1 E(85289): 1.4e-119 Smith-Waterman score: 6473; 99.9% identity (100.0% similar) in 979 aa overlap (1-979:1-979) 10 20 30 40 50 60 pF1KE1 MATQAYTELQAAPPPSQPPQAPPQAQPQPPPPPPPAAPQPPQPPTAAATPQPQYVTELQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MATQAYTELQAAPPPSQPPQAPPQAQPQPPPPPPPAAPQPPQPPTAAATPQPQYVTELQS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 PQPQAQPPGGQKQYVTELPAVPAPSQPTGAPTPSPAPQQYIVVTVSEGAMRASETVSEAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 PQPQAQPPGGQKQYVTELPAVPAPSQPTGAPTPSPAPQQYIVVTVSEGAMRASETVSEAS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 PGSTASQTGVPTQVVQQVQGTQQRLLVQTSVQAKPGHVSPLQLTNIQVPQQALPTQRLVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 PGSTASQTGVPTQVVQQVQGTQQRLLVQTSVQAKPGHVSPLQLTNIQVPQQALPTQRLVV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 QSAAPGSKGGQVSLTVHGTQQVHSPPEQSPVQANSSSSKTAGAPTGTVPQQLQVHGVQQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 QSAAPGSKGGQVSLTVHGTQQVHSPPEQSPVQANSSSSKTAGAPTGTVPQQLQVHGVQQS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 VPVTQERSVVQATPQAPKPGPVQPLTVQGLQPVHVAQEVQQLQQVPVPHVYSSQVQYVEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 VPVTQERSVVQATPQAPKPGPVQPLTVQGLQPVHVAQEVQQLQQVPVPHVYSSQVQYVEG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 GDASYTASAIRSSTYSYPETPLYTQTASTSYYEAAGTATQVSTPATSQAVASSGSMPMYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 GDASYTASAIRSSTYSYPETPLYTQTASTSYYEAAGTATQVSTPATSQAVASSGSMPMYV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 SGSQVVASSASTGAGASNSSGGGGSGGGGGGGGGGGGGGSGSTGGGGSGAGTYVIQGGYM :::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SGSQVVASSTSTGAGASNSSGGGGSGGGGGGGGGGGGGGSGSTGGGGSGAGTYVIQGGYM 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 LGSASQSYSHTTRASPATVQWLLDNYETAEGVSLPRSTLYCHYLLHCQEQKLEPVNAASF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LGSASQSYSHTTRASPATVQWLLDNYETAEGVSLPRSTLYCHYLLHCQEQKLEPVNAASF 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE1 GKLIRSVFMGLRTRRLGTRGNSKYHYYGLRIKASSPLLRLMEDQQHMAMRGQPFSQKQRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 GKLIRSVFMGLRTRRLGTRGNSKYHYYGLRIKASSPLLRLMEDQQHMAMRGQPFSQKQRL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE1 KPIQKMEGMTNGVAVGQQPSTGLSDISAQVQQYQQFLDASRSLPDFTELDLQGKVLPEGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 KPIQKMEGMTNGVAVGQQPSTGLSDISAQVQQYQQFLDASRSLPDFTELDLQGKVLPEGV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE1 GPGDIKAFQVLYREHCEAIVDVMVNLQFTLVETLWKTFWRYNLSQPSEAPPLAVHDEAEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 GPGDIKAFQVLYREHCEAIVDVMVNLQFTLVETLWKTFWRYNLSQPSEAPPLAVHDEAEK 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE1 RLPKAILVLLSKFEPVLQWTKHCDNVLYQGLVEILIPDVLRPIPSALTQAIRNFAKSLES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 RLPKAILVLLSKFEPVLQWTKHCDNVLYQGLVEILIPDVLRPIPSALTQAIRNFAKSLES 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE1 WLTHAMVNIPEEMLRVKVAAAGAFAQTLRRYTSLNHLAQAARAVLQNTAQINQMLSDLNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 WLTHAMVNIPEEMLRVKVAAAGAFAQTLRRYTSLNHLAQAARAVLQNTAQINQMLSDLNR 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE1 VDFANVQEQASWVCRCEDRVVQRLEQDFKVTLQQQNSLEQWAAWLDGVVSQVLKPYQGSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 VDFANVQEQASWVCRCEDRVVQRLEQDFKVTLQQQNSLEQWAAWLDGVVSQVLKPYQGSA 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE1 GFPKAAKLFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMYYLIEHRVAQAKGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 GFPKAAKLFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMYYLIEHRVAQAKGE 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE1 TPIAVMGEFANLATSLNPLDPDKDEEEEEEEESEDELPQDISLAAGGESPALGPETLEPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TPIAVMGEFANLATSLNPLDPDKDEEEEEEEESEDELPQDISLAAGGESPALGPETLEPP 910 920 930 940 950 960 970 pF1KE1 AKLARTDARGLFVQALPSS ::::::::::::::::::: NP_002 AKLARTDARGLFVQALPSS 970 >>XP_011526471 (OMIM: 600006) PREDICTED: MHC class II re (980 aa) initn: 4600 init1: 4600 opt: 4695 Z-score: 1651.8 bits: 317.1 E(85289): 2.9e-85 Smith-Waterman score: 5457; 88.7% identity (88.8% similar) in 980 aa overlap (110-979:1-980) 80 90 100 110 120 130 pF1KE1 AVPAPSQPTGAPTPSPAPQQYIVVTVSEGAMRASETVSEASPGSTASQTGVPTQVVQQVQ :::::::::::::::::::::::::::::: XP_011 MRASETVSEASPGSTASQTGVPTQVVQQVQ 10 20 30 140 150 160 170 180 190 pF1KE1 GTQQRLLVQTSVQAKPGHVSPLQLTNIQVPQQALPTQRLVVQSAAPGSKGGQVSLTVHGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GTQQRLLVQTSVQAKPGHVSPLQLTNIQVPQQALPTQRLVVQSAAPGSKGGQVSLTVHGT 40 50 60 70 80 90 200 210 220 230 240 250 pF1KE1 QQVHSPPEQSPVQANSSSSKTAGAPTGTVPQQLQVHGVQQSVPVTQERSVVQATPQAPKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QQVHSPPEQSPVQANSSSSKTAGAPTGTVPQQLQVHGVQQSVPVTQERSVVQATPQAPKP 100 110 120 130 140 150 260 270 pF1KE1 GPVQPLTVQGLQPVHVAQE----------------------------------------- ::::::::::::::::::: XP_011 GPVQPLTVQGLQPVHVAQESSGSQFPARKAEQRDPRPTPPPEPPPRPPACSGEAPQLGSP 160 170 180 190 200 210 pF1KE1 ------------------------------------------------------------ XP_011 EPPPPHYEPGAEQWVELVGVLPPHLLLPQQKVVFEPLSRLPARASPDQRVRIQRIPQVLV 220 230 240 250 260 270 280 290 300 310 320 pF1KE1 ---------VQQLQQVPVPHVYSSQVQYVEGGDASYTASAIRSSTYSYPETPLYTQTAST ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FGTAATALKVQQLQQVPVPHVYSSQVQYVEGGDASYTASAIRSSTYSYPETPLYTQTAST 280 290 300 310 320 330 330 340 350 360 370 380 pF1KE1 SYYEAAGTATQVSTPATSQAVASSGSMPMYVSGSQVVASSASTGAGASNSSGGGGSGGGG ::::::::::::::::::::::::::::::::::::::::.::::::::::::::::::: XP_011 SYYEAAGTATQVSTPATSQAVASSGSMPMYVSGSQVVASSTSTGAGASNSSGGGGSGGGG 340 350 360 370 380 390 390 400 410 420 430 440 pF1KE1 GGGGGGGGGGSGSTGGGGSGAGTYVIQGGYMLGSASQSYSHTTRASPATVQWLLDNYETA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGGGGGGGGGSGSTGGGGSGAGTYVIQGGYMLGSASQSYSHTTRASPATVQWLLDNYETA 400 410 420 430 440 450 450 460 470 480 490 500 pF1KE1 EGVSLPRSTLYCHYLLHCQEQKLEPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EGVSLPRSTLYCHYLLHCQEQKLEPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGL 460 470 480 490 500 510 510 520 530 540 550 560 pF1KE1 RIKASSPLLRLMEDQQHMAMRGQPFSQKQRLKPIQKMEGMTNGVAVGQQPSTGLSDISAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RIKASSPLLRLMEDQQHMAMRGQPFSQKQRLKPIQKMEGMTNGVAVGQQPSTGLSDISAQ 520 530 540 550 560 570 570 580 590 600 610 620 pF1KE1 VQQYQQFLDASRSLPDFTELDLQGKVLPEGVGPGDIKAFQVLYREHCEAIVDVMVNLQFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VQQYQQFLDASRSLPDFTELDLQGKVLPEGVGPGDIKAFQVLYREHCEAIVDVMVNLQFT 580 590 600 610 620 630 630 640 650 660 670 680 pF1KE1 LVETLWKTFWRYNLSQPSEAPPLAVHDEAEKRLPKAILVLLSKFEPVLQWTKHCDNVLYQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVETLWKTFWRYNLSQPSEAPPLAVHDEAEKRLPKAILVLLSKFEPVLQWTKHCDNVLYQ 640 650 660 670 680 690 690 700 710 720 730 740 pF1KE1 GLVEILIPDVLRPIPSALTQAIRNFAKSLESWLTHAMVNIPEEMLRVKVAAAGAFAQTLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLVEILIPDVLRPIPSALTQAIRNFAKSLESWLTHAMVNIPEEMLRVKVAAAGAFAQTLR 700 710 720 730 740 750 750 760 770 780 790 800 pF1KE1 RYTSLNHLAQAARAVLQNTAQINQMLSDLNRVDFANVQEQASWVCRCEDRVVQRLEQDFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RYTSLNHLAQAARAVLQNTAQINQMLSDLNRVDFANVQEQASWVCRCEDRVVQRLEQDFK 760 770 780 790 800 810 810 820 830 840 850 860 pF1KE1 VTLQQQNSLEQWAAWLDGVVSQVLKPYQGSAGFPKAAKLFLLKWSFYSSMVIRDLTLRSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VTLQQQNSLEQWAAWLDGVVSQVLKPYQGSAGFPKAAKLFLLKWSFYSSMVIRDLTLRSA 820 830 840 850 860 870 870 880 890 900 910 920 pF1KE1 ASFGSFHLIRLLYDEYMYYLIEHRVAQAKGETPIAVMGEFANLATSLNPLDPDKDEEEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ASFGSFHLIRLLYDEYMYYLIEHRVAQAKGETPIAVMGEFANLATSLNPLDPDKDEEEEE 880 890 900 910 920 930 930 940 950 960 970 pF1KE1 EEESEDELPQDISLAAGGESPALGPETLEPPAKLARTDARGLFVQALPSS :::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EEESEDELPQDISLAAGGESPALGPETLEPPAKLARTDARGLFVQALPSS 940 950 960 970 980 >>XP_011526472 (OMIM: 600006) PREDICTED: MHC class II re (980 aa) initn: 4600 init1: 4600 opt: 4695 Z-score: 1651.8 bits: 317.1 E(85289): 2.9e-85 Smith-Waterman score: 5457; 88.7% identity (88.8% similar) in 980 aa overlap (110-979:1-980) 80 90 100 110 120 130 pF1KE1 AVPAPSQPTGAPTPSPAPQQYIVVTVSEGAMRASETVSEASPGSTASQTGVPTQVVQQVQ :::::::::::::::::::::::::::::: XP_011 MRASETVSEASPGSTASQTGVPTQVVQQVQ 10 20 30 140 150 160 170 180 190 pF1KE1 GTQQRLLVQTSVQAKPGHVSPLQLTNIQVPQQALPTQRLVVQSAAPGSKGGQVSLTVHGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GTQQRLLVQTSVQAKPGHVSPLQLTNIQVPQQALPTQRLVVQSAAPGSKGGQVSLTVHGT 40 50 60 70 80 90 200 210 220 230 240 250 pF1KE1 QQVHSPPEQSPVQANSSSSKTAGAPTGTVPQQLQVHGVQQSVPVTQERSVVQATPQAPKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QQVHSPPEQSPVQANSSSSKTAGAPTGTVPQQLQVHGVQQSVPVTQERSVVQATPQAPKP 100 110 120 130 140 150 260 270 pF1KE1 GPVQPLTVQGLQPVHVAQE----------------------------------------- ::::::::::::::::::: XP_011 GPVQPLTVQGLQPVHVAQESSGSQFPARKAEQRDPRPTPPPEPPPRPPACSGEAPQLGSP 160 170 180 190 200 210 pF1KE1 ------------------------------------------------------------ XP_011 EPPPPHYEPGAEQWVELVGVLPPHLLLPQQKVVFEPLSRLPARASPDQRVRIQRIPQVLV 220 230 240 250 260 270 280 290 300 310 320 pF1KE1 ---------VQQLQQVPVPHVYSSQVQYVEGGDASYTASAIRSSTYSYPETPLYTQTAST ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FGTAATALKVQQLQQVPVPHVYSSQVQYVEGGDASYTASAIRSSTYSYPETPLYTQTAST 280 290 300 310 320 330 330 340 350 360 370 380 pF1KE1 SYYEAAGTATQVSTPATSQAVASSGSMPMYVSGSQVVASSASTGAGASNSSGGGGSGGGG ::::::::::::::::::::::::::::::::::::::::.::::::::::::::::::: XP_011 SYYEAAGTATQVSTPATSQAVASSGSMPMYVSGSQVVASSTSTGAGASNSSGGGGSGGGG 340 350 360 370 380 390 390 400 410 420 430 440 pF1KE1 GGGGGGGGGGSGSTGGGGSGAGTYVIQGGYMLGSASQSYSHTTRASPATVQWLLDNYETA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGGGGGGGGGSGSTGGGGSGAGTYVIQGGYMLGSASQSYSHTTRASPATVQWLLDNYETA 400 410 420 430 440 450 450 460 470 480 490 500 pF1KE1 EGVSLPRSTLYCHYLLHCQEQKLEPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EGVSLPRSTLYCHYLLHCQEQKLEPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGL 460 470 480 490 500 510 510 520 530 540 550 560 pF1KE1 RIKASSPLLRLMEDQQHMAMRGQPFSQKQRLKPIQKMEGMTNGVAVGQQPSTGLSDISAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RIKASSPLLRLMEDQQHMAMRGQPFSQKQRLKPIQKMEGMTNGVAVGQQPSTGLSDISAQ 520 530 540 550 560 570 570 580 590 600 610 620 pF1KE1 VQQYQQFLDASRSLPDFTELDLQGKVLPEGVGPGDIKAFQVLYREHCEAIVDVMVNLQFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VQQYQQFLDASRSLPDFTELDLQGKVLPEGVGPGDIKAFQVLYREHCEAIVDVMVNLQFT 580 590 600 610 620 630 630 640 650 660 670 680 pF1KE1 LVETLWKTFWRYNLSQPSEAPPLAVHDEAEKRLPKAILVLLSKFEPVLQWTKHCDNVLYQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVETLWKTFWRYNLSQPSEAPPLAVHDEAEKRLPKAILVLLSKFEPVLQWTKHCDNVLYQ 640 650 660 670 680 690 690 700 710 720 730 740 pF1KE1 GLVEILIPDVLRPIPSALTQAIRNFAKSLESWLTHAMVNIPEEMLRVKVAAAGAFAQTLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLVEILIPDVLRPIPSALTQAIRNFAKSLESWLTHAMVNIPEEMLRVKVAAAGAFAQTLR 700 710 720 730 740 750 750 760 770 780 790 800 pF1KE1 RYTSLNHLAQAARAVLQNTAQINQMLSDLNRVDFANVQEQASWVCRCEDRVVQRLEQDFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RYTSLNHLAQAARAVLQNTAQINQMLSDLNRVDFANVQEQASWVCRCEDRVVQRLEQDFK 760 770 780 790 800 810 810 820 830 840 850 860 pF1KE1 VTLQQQNSLEQWAAWLDGVVSQVLKPYQGSAGFPKAAKLFLLKWSFYSSMVIRDLTLRSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VTLQQQNSLEQWAAWLDGVVSQVLKPYQGSAGFPKAAKLFLLKWSFYSSMVIRDLTLRSA 820 830 840 850 860 870 870 880 890 900 910 920 pF1KE1 ASFGSFHLIRLLYDEYMYYLIEHRVAQAKGETPIAVMGEFANLATSLNPLDPDKDEEEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ASFGSFHLIRLLYDEYMYYLIEHRVAQAKGETPIAVMGEFANLATSLNPLDPDKDEEEEE 880 890 900 910 920 930 930 940 950 960 970 pF1KE1 EEESEDELPQDISLAAGGESPALGPETLEPPAKLARTDARGLFVQALPSS :::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EEESEDELPQDISLAAGGESPALGPETLEPPAKLARTDARGLFVQALPSS 940 950 960 970 980 >>XP_011526467 (OMIM: 600006) PREDICTED: MHC class II re (1089 aa) initn: 4600 init1: 4600 opt: 4695 Z-score: 1651.2 bits: 317.1 E(85289): 3.1e-85 Smith-Waterman score: 5668; 89.0% identity (89.1% similar) in 1011 aa overlap (79-979:79-1089) 50 60 70 80 90 100 pF1KE1 TPQPQYVTELQSPQPQAQPPGGQKQYVTELPAVPAPSQPTGAPTPSPAPQQYIVVTVSEG :::::::::::::::::::::::::::::: XP_011 TPQPQYVTELQSPQPQAQPPGGQKQYVTELPAVPAPSQPTGAPTPSPAPQQYIVVTVSEG 50 60 70 80 90 100 110 120 130 140 150 160 pF1KE1 AMRASETVSEASPGSTASQTGVPTQVVQQVQGTQQRLLVQTSVQAKPGHVSPLQLTNIQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AMRASETVSEASPGSTASQTGVPTQVVQQVQGTQQRLLVQTSVQAKPGHVSPLQLTNIQV 110 120 130 140 150 160 170 180 190 200 210 220 pF1KE1 PQQALPTQRLVVQSAAPGSKGGQVSLTVHGTQQVHSPPEQSPVQANSSSSKTAGAPTGTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PQQALPTQRLVVQSAAPGSKGGQVSLTVHGTQQVHSPPEQSPVQANSSSSKTAGAPTGTV 170 180 190 200 210 220 230 240 250 260 270 pF1KE1 PQQLQVHGVQQSVPVTQERSVVQATPQAPKPGPVQPLTVQGLQPVHVAQE---------- :::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PQQLQVHGVQQSVPVTQERSVVQATPQAPKPGPVQPLTVQGLQPVHVAQESSGSQFPARK 230 240 250 260 270 280 pF1KE1 ------------------------------------------------------------ XP_011 AEQRDPRPTPPPEPPPRPPACSGEAPQLGSPEPPPPHYEPGAEQWVELVGVLPPHLLLPQ 290 300 310 320 330 340 280 290 pF1KE1 ----------------------------------------VQQLQQVPVPHVYSSQVQYV :::::::::::::::::::: XP_011 QKVVFEPLSRLPARASPDQRVRIQRIPQVLVFGTAATALKVQQLQQVPVPHVYSSQVQYV 350 360 370 380 390 400 300 310 320 330 340 350 pF1KE1 EGGDASYTASAIRSSTYSYPETPLYTQTASTSYYEAAGTATQVSTPATSQAVASSGSMPM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EGGDASYTASAIRSSTYSYPETPLYTQTASTSYYEAAGTATQVSTPATSQAVASSGSMPM 410 420 430 440 450 460 360 370 380 390 400 410 pF1KE1 YVSGSQVVASSASTGAGASNSSGGGGSGGGGGGGGGGGGGGSGSTGGGGSGAGTYVIQGG :::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YVSGSQVVASSTSTGAGASNSSGGGGSGGGGGGGGGGGGGGSGSTGGGGSGAGTYVIQGG 470 480 490 500 510 520 420 430 440 450 460 470 pF1KE1 YMLGSASQSYSHTTRASPATVQWLLDNYETAEGVSLPRSTLYCHYLLHCQEQKLEPVNAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YMLGSASQSYSHTTRASPATVQWLLDNYETAEGVSLPRSTLYCHYLLHCQEQKLEPVNAA 530 540 550 560 570 580 480 490 500 510 520 530 pF1KE1 SFGKLIRSVFMGLRTRRLGTRGNSKYHYYGLRIKASSPLLRLMEDQQHMAMRGQPFSQKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SFGKLIRSVFMGLRTRRLGTRGNSKYHYYGLRIKASSPLLRLMEDQQHMAMRGQPFSQKQ 590 600 610 620 630 640 540 550 560 570 580 590 pF1KE1 RLKPIQKMEGMTNGVAVGQQPSTGLSDISAQVQQYQQFLDASRSLPDFTELDLQGKVLPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RLKPIQKMEGMTNGVAVGQQPSTGLSDISAQVQQYQQFLDASRSLPDFTELDLQGKVLPE 650 660 670 680 690 700 600 610 620 630 640 650 pF1KE1 GVGPGDIKAFQVLYREHCEAIVDVMVNLQFTLVETLWKTFWRYNLSQPSEAPPLAVHDEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GVGPGDIKAFQVLYREHCEAIVDVMVNLQFTLVETLWKTFWRYNLSQPSEAPPLAVHDEA 710 720 730 740 750 760 660 670 680 690 700 710 pF1KE1 EKRLPKAILVLLSKFEPVLQWTKHCDNVLYQGLVEILIPDVLRPIPSALTQAIRNFAKSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKRLPKAILVLLSKFEPVLQWTKHCDNVLYQGLVEILIPDVLRPIPSALTQAIRNFAKSL 770 780 790 800 810 820 720 730 740 750 760 770 pF1KE1 ESWLTHAMVNIPEEMLRVKVAAAGAFAQTLRRYTSLNHLAQAARAVLQNTAQINQMLSDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ESWLTHAMVNIPEEMLRVKVAAAGAFAQTLRRYTSLNHLAQAARAVLQNTAQINQMLSDL 830 840 850 860 870 880 780 790 800 810 820 830 pF1KE1 NRVDFANVQEQASWVCRCEDRVVQRLEQDFKVTLQQQNSLEQWAAWLDGVVSQVLKPYQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NRVDFANVQEQASWVCRCEDRVVQRLEQDFKVTLQQQNSLEQWAAWLDGVVSQVLKPYQG 890 900 910 920 930 940 840 850 860 870 880 890 pF1KE1 SAGFPKAAKLFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMYYLIEHRVAQAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SAGFPKAAKLFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMYYLIEHRVAQAK 950 960 970 980 990 1000 900 910 920 930 940 950 pF1KE1 GETPIAVMGEFANLATSLNPLDPDKDEEEEEEEESEDELPQDISLAAGGESPALGPETLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GETPIAVMGEFANLATSLNPLDPDKDEEEEEEEESEDELPQDISLAAGGESPALGPETLE 1010 1020 1030 1040 1050 1060 960 970 pF1KE1 PPAKLARTDARGLFVQALPSS ::::::::::::::::::::: XP_011 PPAKLARTDARGLFVQALPSS 1070 1080 >-- initn: 575 init1: 575 opt: 575 Z-score: 223.7 bits: 53.0 E(85289): 1e-05 Smith-Waterman score: 575; 100.0% identity (100.0% similar) in 78 aa overlap (1-78:1-78) 10 20 30 40 50 60 pF1KE1 MATQAYTELQAAPPPSQPPQAPPQAQPQPPPPPPPAAPQPPQPPTAAATPQPQYVTELQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MATQAYTELQAAPPPSQPPQAPPQAQPQPPPPPPPAAPQPPQPPTAAATPQPQYVTELQS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 PQPQAQPPGGQKQYVTELPAVPAPSQPTGAPTPSPAPQQYIVVTVSEGAMRASETVSEAS :::::::::::::::::: XP_011 PQPQAQPPGGQKQYVTELPAVPAPSQPTGAPTPSPAPQQYIVVTVSEGAMRASETVSEAS 70 80 90 100 110 120 >>XP_011526468 (OMIM: 600006) PREDICTED: MHC class II re (1089 aa) initn: 4600 init1: 4600 opt: 4695 Z-score: 1651.2 bits: 317.1 E(85289): 3.1e-85 Smith-Waterman score: 5668; 89.0% identity (89.1% similar) in 1011 aa overlap (79-979:79-1089) 50 60 70 80 90 100 pF1KE1 TPQPQYVTELQSPQPQAQPPGGQKQYVTELPAVPAPSQPTGAPTPSPAPQQYIVVTVSEG :::::::::::::::::::::::::::::: XP_011 TPQPQYVTELQSPQPQAQPPGGQKQYVTELPAVPAPSQPTGAPTPSPAPQQYIVVTVSEG 50 60 70 80 90 100 110 120 130 140 150 160 pF1KE1 AMRASETVSEASPGSTASQTGVPTQVVQQVQGTQQRLLVQTSVQAKPGHVSPLQLTNIQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AMRASETVSEASPGSTASQTGVPTQVVQQVQGTQQRLLVQTSVQAKPGHVSPLQLTNIQV 110 120 130 140 150 160 170 180 190 200 210 220 pF1KE1 PQQALPTQRLVVQSAAPGSKGGQVSLTVHGTQQVHSPPEQSPVQANSSSSKTAGAPTGTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PQQALPTQRLVVQSAAPGSKGGQVSLTVHGTQQVHSPPEQSPVQANSSSSKTAGAPTGTV 170 180 190 200 210 220 230 240 250 260 270 pF1KE1 PQQLQVHGVQQSVPVTQERSVVQATPQAPKPGPVQPLTVQGLQPVHVAQE---------- :::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PQQLQVHGVQQSVPVTQERSVVQATPQAPKPGPVQPLTVQGLQPVHVAQESSGSQFPARK 230 240 250 260 270 280 pF1KE1 ------------------------------------------------------------ XP_011 AEQRDPRPTPPPEPPPRPPACSGEAPQLGSPEPPPPHYEPGAEQWVELVGVLPPHLLLPQ 290 300 310 320 330 340 280 290 pF1KE1 ----------------------------------------VQQLQQVPVPHVYSSQVQYV :::::::::::::::::::: XP_011 QKVVFEPLSRLPARASPDQRVRIQRIPQVLVFGTAATALKVQQLQQVPVPHVYSSQVQYV 350 360 370 380 390 400 300 310 320 330 340 350 pF1KE1 EGGDASYTASAIRSSTYSYPETPLYTQTASTSYYEAAGTATQVSTPATSQAVASSGSMPM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EGGDASYTASAIRSSTYSYPETPLYTQTASTSYYEAAGTATQVSTPATSQAVASSGSMPM 410 420 430 440 450 460 360 370 380 390 400 410 pF1KE1 YVSGSQVVASSASTGAGASNSSGGGGSGGGGGGGGGGGGGGSGSTGGGGSGAGTYVIQGG :::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YVSGSQVVASSTSTGAGASNSSGGGGSGGGGGGGGGGGGGGSGSTGGGGSGAGTYVIQGG 470 480 490 500 510 520 420 430 440 450 460 470 pF1KE1 YMLGSASQSYSHTTRASPATVQWLLDNYETAEGVSLPRSTLYCHYLLHCQEQKLEPVNAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YMLGSASQSYSHTTRASPATVQWLLDNYETAEGVSLPRSTLYCHYLLHCQEQKLEPVNAA 530 540 550 560 570 580 480 490 500 510 520 530 pF1KE1 SFGKLIRSVFMGLRTRRLGTRGNSKYHYYGLRIKASSPLLRLMEDQQHMAMRGQPFSQKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SFGKLIRSVFMGLRTRRLGTRGNSKYHYYGLRIKASSPLLRLMEDQQHMAMRGQPFSQKQ 590 600 610 620 630 640 540 550 560 570 580 590 pF1KE1 RLKPIQKMEGMTNGVAVGQQPSTGLSDISAQVQQYQQFLDASRSLPDFTELDLQGKVLPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RLKPIQKMEGMTNGVAVGQQPSTGLSDISAQVQQYQQFLDASRSLPDFTELDLQGKVLPE 650 660 670 680 690 700 600 610 620 630 640 650 pF1KE1 GVGPGDIKAFQVLYREHCEAIVDVMVNLQFTLVETLWKTFWRYNLSQPSEAPPLAVHDEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GVGPGDIKAFQVLYREHCEAIVDVMVNLQFTLVETLWKTFWRYNLSQPSEAPPLAVHDEA 710 720 730 740 750 760 660 670 680 690 700 710 pF1KE1 EKRLPKAILVLLSKFEPVLQWTKHCDNVLYQGLVEILIPDVLRPIPSALTQAIRNFAKSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKRLPKAILVLLSKFEPVLQWTKHCDNVLYQGLVEILIPDVLRPIPSALTQAIRNFAKSL 770 780 790 800 810 820 720 730 740 750 760 770 pF1KE1 ESWLTHAMVNIPEEMLRVKVAAAGAFAQTLRRYTSLNHLAQAARAVLQNTAQINQMLSDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ESWLTHAMVNIPEEMLRVKVAAAGAFAQTLRRYTSLNHLAQAARAVLQNTAQINQMLSDL 830 840 850 860 870 880 780 790 800 810 820 830 pF1KE1 NRVDFANVQEQASWVCRCEDRVVQRLEQDFKVTLQQQNSLEQWAAWLDGVVSQVLKPYQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NRVDFANVQEQASWVCRCEDRVVQRLEQDFKVTLQQQNSLEQWAAWLDGVVSQVLKPYQG 890 900 910 920 930 940 840 850 860 870 880 890 pF1KE1 SAGFPKAAKLFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMYYLIEHRVAQAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SAGFPKAAKLFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMYYLIEHRVAQAK 950 960 970 980 990 1000 900 910 920 930 940 950 pF1KE1 GETPIAVMGEFANLATSLNPLDPDKDEEEEEEEESEDELPQDISLAAGGESPALGPETLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GETPIAVMGEFANLATSLNPLDPDKDEEEEEEEESEDELPQDISLAAGGESPALGPETLE 1010 1020 1030 1040 1050 1060 960 970 pF1KE1 PPAKLARTDARGLFVQALPSS ::::::::::::::::::::: XP_011 PPAKLARTDARGLFVQALPSS 1070 1080 >-- initn: 575 init1: 575 opt: 575 Z-score: 223.7 bits: 53.0 E(85289): 1e-05 Smith-Waterman score: 575; 100.0% identity (100.0% similar) in 78 aa overlap (1-78:1-78) 10 20 30 40 50 60 pF1KE1 MATQAYTELQAAPPPSQPPQAPPQAQPQPPPPPPPAAPQPPQPPTAAATPQPQYVTELQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MATQAYTELQAAPPPSQPPQAPPQAQPQPPPPPPPAAPQPPQPPTAAATPQPQYVTELQS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 PQPQAQPPGGQKQYVTELPAVPAPSQPTGAPTPSPAPQQYIVVTVSEGAMRASETVSEAS :::::::::::::::::: XP_011 PQPQAQPPGGQKQYVTELPAVPAPSQPTGAPTPSPAPQQYIVVTVSEGAMRASETVSEAS 70 80 90 100 110 120 >>XP_011526469 (OMIM: 600006) PREDICTED: MHC class II re (1089 aa) initn: 4600 init1: 4600 opt: 4695 Z-score: 1651.2 bits: 317.1 E(85289): 3.1e-85 Smith-Waterman score: 5668; 89.0% identity (89.1% similar) in 1011 aa overlap (79-979:79-1089) 50 60 70 80 90 100 pF1KE1 TPQPQYVTELQSPQPQAQPPGGQKQYVTELPAVPAPSQPTGAPTPSPAPQQYIVVTVSEG :::::::::::::::::::::::::::::: XP_011 TPQPQYVTELQSPQPQAQPPGGQKQYVTELPAVPAPSQPTGAPTPSPAPQQYIVVTVSEG 50 60 70 80 90 100 110 120 130 140 150 160 pF1KE1 AMRASETVSEASPGSTASQTGVPTQVVQQVQGTQQRLLVQTSVQAKPGHVSPLQLTNIQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AMRASETVSEASPGSTASQTGVPTQVVQQVQGTQQRLLVQTSVQAKPGHVSPLQLTNIQV 110 120 130 140 150 160 170 180 190 200 210 220 pF1KE1 PQQALPTQRLVVQSAAPGSKGGQVSLTVHGTQQVHSPPEQSPVQANSSSSKTAGAPTGTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PQQALPTQRLVVQSAAPGSKGGQVSLTVHGTQQVHSPPEQSPVQANSSSSKTAGAPTGTV 170 180 190 200 210 220 230 240 250 260 270 pF1KE1 PQQLQVHGVQQSVPVTQERSVVQATPQAPKPGPVQPLTVQGLQPVHVAQE---------- :::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PQQLQVHGVQQSVPVTQERSVVQATPQAPKPGPVQPLTVQGLQPVHVAQESSGSQFPARK 230 240 250 260 270 280 pF1KE1 ------------------------------------------------------------ XP_011 AEQRDPRPTPPPEPPPRPPACSGEAPQLGSPEPPPPHYEPGAEQWVELVGVLPPHLLLPQ 290 300 310 320 330 340 280 290 pF1KE1 ----------------------------------------VQQLQQVPVPHVYSSQVQYV :::::::::::::::::::: XP_011 QKVVFEPLSRLPARASPDQRVRIQRIPQVLVFGTAATALKVQQLQQVPVPHVYSSQVQYV 350 360 370 380 390 400 300 310 320 330 340 350 pF1KE1 EGGDASYTASAIRSSTYSYPETPLYTQTASTSYYEAAGTATQVSTPATSQAVASSGSMPM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EGGDASYTASAIRSSTYSYPETPLYTQTASTSYYEAAGTATQVSTPATSQAVASSGSMPM 410 420 430 440 450 460 360 370 380 390 400 410 pF1KE1 YVSGSQVVASSASTGAGASNSSGGGGSGGGGGGGGGGGGGGSGSTGGGGSGAGTYVIQGG :::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YVSGSQVVASSTSTGAGASNSSGGGGSGGGGGGGGGGGGGGSGSTGGGGSGAGTYVIQGG 470 480 490 500 510 520 420 430 440 450 460 470 pF1KE1 YMLGSASQSYSHTTRASPATVQWLLDNYETAEGVSLPRSTLYCHYLLHCQEQKLEPVNAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YMLGSASQSYSHTTRASPATVQWLLDNYETAEGVSLPRSTLYCHYLLHCQEQKLEPVNAA 530 540 550 560 570 580 480 490 500 510 520 530 pF1KE1 SFGKLIRSVFMGLRTRRLGTRGNSKYHYYGLRIKASSPLLRLMEDQQHMAMRGQPFSQKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SFGKLIRSVFMGLRTRRLGTRGNSKYHYYGLRIKASSPLLRLMEDQQHMAMRGQPFSQKQ 590 600 610 620 630 640 540 550 560 570 580 590 pF1KE1 RLKPIQKMEGMTNGVAVGQQPSTGLSDISAQVQQYQQFLDASRSLPDFTELDLQGKVLPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RLKPIQKMEGMTNGVAVGQQPSTGLSDISAQVQQYQQFLDASRSLPDFTELDLQGKVLPE 650 660 670 680 690 700 600 610 620 630 640 650 pF1KE1 GVGPGDIKAFQVLYREHCEAIVDVMVNLQFTLVETLWKTFWRYNLSQPSEAPPLAVHDEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GVGPGDIKAFQVLYREHCEAIVDVMVNLQFTLVETLWKTFWRYNLSQPSEAPPLAVHDEA 710 720 730 740 750 760 660 670 680 690 700 710 pF1KE1 EKRLPKAILVLLSKFEPVLQWTKHCDNVLYQGLVEILIPDVLRPIPSALTQAIRNFAKSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKRLPKAILVLLSKFEPVLQWTKHCDNVLYQGLVEILIPDVLRPIPSALTQAIRNFAKSL 770 780 790 800 810 820 720 730 740 750 760 770 pF1KE1 ESWLTHAMVNIPEEMLRVKVAAAGAFAQTLRRYTSLNHLAQAARAVLQNTAQINQMLSDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ESWLTHAMVNIPEEMLRVKVAAAGAFAQTLRRYTSLNHLAQAARAVLQNTAQINQMLSDL 830 840 850 860 870 880 780 790 800 810 820 830 pF1KE1 NRVDFANVQEQASWVCRCEDRVVQRLEQDFKVTLQQQNSLEQWAAWLDGVVSQVLKPYQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NRVDFANVQEQASWVCRCEDRVVQRLEQDFKVTLQQQNSLEQWAAWLDGVVSQVLKPYQG 890 900 910 920 930 940 840 850 860 870 880 890 pF1KE1 SAGFPKAAKLFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMYYLIEHRVAQAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SAGFPKAAKLFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMYYLIEHRVAQAK 950 960 970 980 990 1000 900 910 920 930 940 950 pF1KE1 GETPIAVMGEFANLATSLNPLDPDKDEEEEEEEESEDELPQDISLAAGGESPALGPETLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GETPIAVMGEFANLATSLNPLDPDKDEEEEEEEESEDELPQDISLAAGGESPALGPETLE 1010 1020 1030 1040 1050 1060 960 970 pF1KE1 PPAKLARTDARGLFVQALPSS ::::::::::::::::::::: XP_011 PPAKLARTDARGLFVQALPSS 1070 1080 >-- initn: 575 init1: 575 opt: 575 Z-score: 223.7 bits: 53.0 E(85289): 1e-05 Smith-Waterman score: 575; 100.0% identity (100.0% similar) in 78 aa overlap (1-78:1-78) 10 20 30 40 50 60 pF1KE1 MATQAYTELQAAPPPSQPPQAPPQAQPQPPPPPPPAAPQPPQPPTAAATPQPQYVTELQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MATQAYTELQAAPPPSQPPQAPPQAQPQPPPPPPPAAPQPPQPPTAAATPQPQYVTELQS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 PQPQAQPPGGQKQYVTELPAVPAPSQPTGAPTPSPAPQQYIVVTVSEGAMRASETVSEAS :::::::::::::::::: XP_011 PQPQAQPPGGQKQYVTELPAVPAPSQPTGAPTPSPAPQQYIVVTVSEGAMRASETVSEAS 70 80 90 100 110 120 >>XP_011526470 (OMIM: 600006) PREDICTED: MHC class II re (991 aa) initn: 5447 init1: 3584 opt: 3749 Z-score: 1324.0 bits: 256.5 E(85289): 5.2e-67 Smith-Waterman score: 5406; 80.9% identity (80.9% similar) in 1089 aa overlap (1-979:1-991) 10 20 30 40 50 60 pF1KE1 MATQAYTELQAAPPPSQPPQAPPQAQPQPPPPPPPAAPQPPQPPTAAATPQPQYVTELQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MATQAYTELQAAPPPSQPPQAPPQAQPQPPPPPPPAAPQPPQPPTAAATPQPQYVTELQS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 PQPQAQPPGGQKQYVTELPAVPAPSQPTGAPTPSPAPQQYIVVTVSEGAMRASETVSEAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PQPQAQPPGGQKQYVTELPAVPAPSQPTGAPTPSPAPQQYIVVTVSEGAMRASETVSEAS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 PGSTASQTGVPTQVVQQVQGTQQRLLVQTSVQAKPGHVSPLQLTNIQVPQQALPTQRLVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGSTASQTGVPTQVVQQVQGTQQRLLVQTSVQAKPGHVSPLQLTNIQVPQQALPTQRLVV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 QSAAPGSKGGQVSLTVHGTQQVHSPPEQSPVQANSSSSKTAGAPTGTVPQQLQVHGVQQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QSAAPGSKGGQVSLTVHGTQQVHSPPEQSPVQANSSSSKTAGAPTGTVPQQLQVHGVQQS 190 200 210 220 230 240 250 260 270 pF1KE1 VPVTQERSVVQATPQAPKPGPVQPLTVQGLQPVHVAQE---------------------- :::::::::::::::::::::::::::::::::::::: XP_011 VPVTQERSVVQATPQAPKPGPVQPLTVQGLQPVHVAQESSGSQFPARKAEQRDPRPTPPP 250 260 270 280 290 300 pF1KE1 ------------------------------------------------------------ XP_011 EPPPRPPACSGEAPQLGSPEPPPPHYEPGAEQWVELVGVLPPHLLLPQQKVVFEPLSRLP 310 320 330 340 350 360 280 290 300 310 pF1KE1 ----------------------------VQQLQQVPVPHVYSSQVQYVEGGDASYTASAI :::::::::::::::::::::::::::::::: XP_011 ARASPDQRVRIQRIPQVLVFGTAATALKVQQLQQVPVPHVYSSQVQYVEGGDASYTASAI 370 380 390 400 410 420 320 330 340 350 360 370 pF1KE1 RSSTYSYPETPLYTQTASTSYYEAAGTATQVSTPATSQAVASSGSMPMYVSGSQVVASSA ::::::::::::::::::::::::::::::: XP_011 RSSTYSYPETPLYTQTASTSYYEAAGTATQV----------------------------- 430 440 450 380 390 400 410 420 430 pF1KE1 STGAGASNSSGGGGSGGGGGGGGGGGGGGSGSTGGGGSGAGTYVIQGGYMLGSASQSYSH XP_011 ------------------------------------------------------------ 440 450 460 470 480 490 pF1KE1 TTRASPATVQWLLDNYETAEGVSLPRSTLYCHYLLHCQEQKLEPVNAASFGKLIRSVFMG ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ---------QWLLDNYETAEGVSLPRSTLYCHYLLHCQEQKLEPVNAASFGKLIRSVFMG 460 470 480 490 500 500 510 520 530 540 550 pF1KE1 LRTRRLGTRGNSKYHYYGLRIKASSPLLRLMEDQQHMAMRGQPFSQKQRLKPIQKMEGMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRTRRLGTRGNSKYHYYGLRIKASSPLLRLMEDQQHMAMRGQPFSQKQRLKPIQKMEGMT 510 520 530 540 550 560 560 570 580 590 600 610 pF1KE1 NGVAVGQQPSTGLSDISAQVQQYQQFLDASRSLPDFTELDLQGKVLPEGVGPGDIKAFQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NGVAVGQQPSTGLSDISAQVQQYQQFLDASRSLPDFTELDLQGKVLPEGVGPGDIKAFQV 570 580 590 600 610 620 620 630 640 650 660 670 pF1KE1 LYREHCEAIVDVMVNLQFTLVETLWKTFWRYNLSQPSEAPPLAVHDEAEKRLPKAILVLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LYREHCEAIVDVMVNLQFTLVETLWKTFWRYNLSQPSEAPPLAVHDEAEKRLPKAILVLL 630 640 650 660 670 680 680 690 700 710 720 730 pF1KE1 SKFEPVLQWTKHCDNVLYQGLVEILIPDVLRPIPSALTQAIRNFAKSLESWLTHAMVNIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SKFEPVLQWTKHCDNVLYQGLVEILIPDVLRPIPSALTQAIRNFAKSLESWLTHAMVNIP 690 700 710 720 730 740 740 750 760 770 780 790 pF1KE1 EEMLRVKVAAAGAFAQTLRRYTSLNHLAQAARAVLQNTAQINQMLSDLNRVDFANVQEQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EEMLRVKVAAAGAFAQTLRRYTSLNHLAQAARAVLQNTAQINQMLSDLNRVDFANVQEQA 750 760 770 780 790 800 800 810 820 830 840 850 pF1KE1 SWVCRCEDRVVQRLEQDFKVTLQQQNSLEQWAAWLDGVVSQVLKPYQGSAGFPKAAKLFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SWVCRCEDRVVQRLEQDFKVTLQQQNSLEQWAAWLDGVVSQVLKPYQGSAGFPKAAKLFL 810 820 830 840 850 860 860 870 880 890 900 910 pF1KE1 LKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMYYLIEHRVAQAKGETPIAVMGEFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMYYLIEHRVAQAKGETPIAVMGEFA 870 880 890 900 910 920 920 930 940 950 960 970 pF1KE1 NLATSLNPLDPDKDEEEEEEEESEDELPQDISLAAGGESPALGPETLEPPAKLARTDARG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NLATSLNPLDPDKDEEEEEEEESEDELPQDISLAAGGESPALGPETLEPPAKLARTDARG 930 940 950 960 970 980 pF1KE1 LFVQALPSS ::::::::: XP_011 LFVQALPSS 990 >>XP_016870490 (OMIM: 601337) PREDICTED: transcription f (724 aa) initn: 2407 init1: 1360 opt: 2484 Z-score: 887.5 bits: 175.2 E(85289): 1.1e-42 Smith-Waterman score: 2671; 62.0% identity (82.2% similar) in 676 aa overlap (268-937:29-659) 240 250 260 270 280 290 pF1KE1 QQSVPVTQERSVVQATPQAPKPGPVQPLTVQGLQPVHVAQEVQQLQQVP-VPHVYSSQVQ : .: : : :.:::.: : : ::: .::: XP_016 MQTSETGSDTGSTVTLQTSVASQAAVPTQVVQQVPVQQQVQQVQTVQQVQHVYPAQVQ 10 20 30 40 50 300 310 320 330 340 350 pF1KE1 YVEGGDASYTASAIRSSTYSYPETPLYTQTASTSYYEAAGTATQVSTPATSQAVASSGSM ::::.:. :: .:::..:: : :: .:.:... .:... :...::.: ..:......:.. XP_016 YVEGSDTVYTNGAIRTTTYPYTETQMYSQNTGGNYFDTQGSSAQVTTVVSSHSMVGTGGI 60 70 80 90 100 110 360 370 380 390 400 410 pF1KE1 PMYVSGSQVVASSASTGAGASNSSGGGGSGGGGGGGGGGGGGGSGSTGGGGSGAGTYVIQ : :.:.:...::. :::.: XP_016 QMGVTGGQLISSSG----------------------------------------GTYLI- 120 130 420 430 440 450 460 470 pF1KE1 GGYMLGSASQSYSHTTRASPATVQWLLDNYETAEGVSLPRSTLYCHYLLHCQEQKLEPVN : . ....: .:::::::::.::::::::::::::::::::: ::: ::::.::.::: XP_016 -GNSMENSGHSVTHTTRASPATLQWLLDNYETAEGVSLPRSTLYNHYLRHCQEHKLDPVN 140 150 160 170 180 190 480 490 500 510 520 530 pF1KE1 AASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGLRIKASSPLLRLMEDQQHMAMRGQPFSQ ::::::::::.:::::::::::::::::::::.:.: .::: ::.::.:.:::: ::..: XP_016 AASFGKLIRSIFMGLRTRRLGTRGNSKYHYYGIRVKPDSPLNRLQEDMQYMAMRQQPMQQ 200 210 220 230 240 250 540 550 560 570 580 590 pF1KE1 KQRLKPIQKMEGMTNG-VAVGQQPSTGLSD-ISAQVQQYQQFLDASRSLPDFTELDLQGK ::: ::.::..:...: .. ::: .:.. . . :: :..::::::::.::.: :..... XP_016 KQRYKPMQKVDGVADGFTGSGQQTGTSVEQTVIAQSQHHQQFLDASRALPEFGEVEISS- 260 270 280 290 300 310 600 610 620 630 640 650 pF1KE1 VLPEGVGPGDIKAFQVLYREHCEAIVDVMVNLQFTLVETLWKTFWRYNLSQPSEAPPLAV ::.:. :::..: :::::::::.::.:::::.:.: ::.:::::. : :... .. XP_016 -LPDGTTFEDIKSLQSLYREHCEAILDVVVNLQFSLIEKLWQTFWRYSPSTPTDGTTITE 320 330 340 350 360 370 660 670 680 690 700 710 pF1KE1 HD---EAEKRLPKAILVLLSKFEPVLQWTKHCDNVLYQGLVEILIPDVLRPIPSALTQAI . : :.::::: :. : : : .:.: .::. .::.::::::::::::::::::::: XP_016 SSNLSEIESRLPKAKLITLCKHESILKWMCNCDHGMYQALVEILIPDVLRPIPSALTQAI 380 390 400 410 420 430 720 730 740 750 760 770 pF1KE1 RNFAKSLESWLTHAMVNIPEEMLRVKVAAAGAFAQTLRRYTSLNHLAQAARAVLQNTAQI ::::::::.::..:: :::..:...::::..::::::::::::::::::::::::::.:: XP_016 RNFAKSLEGWLSNAMNNIPQRMIQTKVAAVSAFAQTLRRYTSLNHLAQAARAVLQNTSQI 440 450 460 470 480 490 780 790 800 810 820 830 pF1KE1 NQMLSDLNRVDFANVQEQASWVCRCEDRVVQRLEQDFKVTLQQQNSLEQWAAWLDGVVSQ :::::::::::::::::::::::.:.: .::::: :::.:::::..:::::::::.:. : XP_016 NQMLSDLNRVDFANVQEQASWVCQCDDNMVQRLETDFKMTLQQQSTLEQWAAWLDNVMMQ 500 510 520 530 540 550 840 850 860 870 880 890 pF1KE1 VLKPYQGSAGFPKAAKLFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMYYLIE .::::.: .:::::. ::::::::::::::::::::::::::::::::::::::.::.: XP_016 ALKPYEGRPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVE 560 570 580 590 600 610 900 910 920 930 940 950 pF1KE1 HRVAQAKGETPIAVMGEFANLATSLNPLDPDKDEEEEEEEESEDELPQDISLAAGGESPA :::::: :::::::::::..: ....: . :::: : : : ..:: XP_016 HRVAQATGETPIAVMGEFGDL-NAVSPGNLDKDEGSEVESEMDEELDDSSEPQAKREKTE 620 630 640 650 660 670 960 970 pF1KE1 LGPETLEPPAKLARTDARGLFVQALPSS XP_016 LSQAFPVGCMQPVLETGVQPSLLNPIHSEHIVTSTQTIRQCSATGNTYTAV 680 690 700 710 720 >>NP_001269045 (OMIM: 601337) transcription factor RFX3 (749 aa) initn: 2571 init1: 1360 opt: 2439 Z-score: 871.7 bits: 172.4 E(85289): 8.1e-42 Smith-Waterman score: 2636; 61.2% identity (82.3% similar) in 677 aa overlap (268-937:29-684) 240 250 260 270 280 290 pF1KE1 QQSVPVTQERSVVQATPQAPKPGPVQPLTVQGLQPVHVAQEVQQLQQVP-VPHVYSSQVQ : .: : : :.:::.: : : ::: .::: NP_001 MQTSETGSDTGSTVTLQTSVASQAAVPTQVVQQVPVQQQVQQVQTVQQVQHVYPAQVQ 10 20 30 40 50 300 310 320 330 340 350 pF1KE1 YVEGGDASYTASAIRSSTYSYPETPLYTQTASTSYYEAAGTATQVSTPATSQAVASSGSM ::::.:. :: .:::..:: : :: .:.:... .:... :...::.: ..:......:.. NP_001 YVEGSDTVYTNGAIRTTTYPYTETQMYSQNTGGNYFDTQGSSAQVTTVVSSHSMVGTGGI 60 70 80 90 100 110 360 370 380 390 400 410 pF1KE1 PMYVSGSQVVASSASTGAGASNSSGGGGSGGGGGGGGGGGGGGSGSTGGGGSGAGTYVIQ : :.:.:...:: :: :.. .:: . . :. .:. NP_001 QMGVTGGQLISSS------------------GGTYLIGNSMENSGHSVTHTTRASPATIE 120 130 140 150 160 420 430 440 450 460 470 pF1KE1 GGYMLGSASQSYS-HTTRASPATVQWLLDNYETAEGVSLPRSTLYCHYLLHCQEQKLEPV . . :.. : : . . .::::::::::::::::::::: ::: ::::.::.:: NP_001 MAIETLQKSDGLSTHRSSLLNSHLQWLLDNYETAEGVSLPRSTLYNHYLRHCQEHKLDPV 170 180 190 200 210 220 480 490 500 510 520 530 pF1KE1 NAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGLRIKASSPLLRLMEDQQHMAMRGQPFS :::::::::::.:::::::::::::::::::::.:.: .::: ::.::.:.:::: ::.. NP_001 NAASFGKLIRSIFMGLRTRRLGTRGNSKYHYYGIRVKPDSPLNRLQEDMQYMAMRQQPMQ 230 240 250 260 270 280 540 550 560 570 580 590 pF1KE1 QKQRLKPIQKMEGMTNG-VAVGQQPSTGLSD-ISAQVQQYQQFLDASRSLPDFTELDLQG :::: ::.::..:...: .. ::: .:.. . . :: :..::::::::.::.: :..... NP_001 QKQRYKPMQKVDGVADGFTGSGQQTGTSVEQTVIAQSQHHQQFLDASRALPEFGEVEISS 290 300 310 320 330 340 600 610 620 630 640 650 pF1KE1 KVLPEGVGPGDIKAFQVLYREHCEAIVDVMVNLQFTLVETLWKTFWRYNLSQPSEAPPLA ::.:. :::..: :::::::::.::.:::::.:.: ::.:::::. : :... .. NP_001 --LPDGTTFEDIKSLQSLYREHCEAILDVVVNLQFSLIEKLWQTFWRYSPSTPTDGTTIT 350 360 370 380 390 660 670 680 690 700 710 pF1KE1 VHD---EAEKRLPKAILVLLSKFEPVLQWTKHCDNVLYQGLVEILIPDVLRPIPSALTQA . : :.::::: :. : : : .:.: .::. .::.:::::::::::::::::::: NP_001 ESSNLSEIESRLPKAKLITLCKHESILKWMCNCDHGMYQALVEILIPDVLRPIPSALTQA 400 410 420 430 440 450 720 730 740 750 760 770 pF1KE1 IRNFAKSLESWLTHAMVNIPEEMLRVKVAAAGAFAQTLRRYTSLNHLAQAARAVLQNTAQ :::::::::.::..:: :::..:...::::..::::::::::::::::::::::::::.: NP_001 IRNFAKSLEGWLSNAMNNIPQRMIQTKVAAVSAFAQTLRRYTSLNHLAQAARAVLQNTSQ 460 470 480 490 500 510 780 790 800 810 820 830 pF1KE1 INQMLSDLNRVDFANVQEQASWVCRCEDRVVQRLEQDFKVTLQQQNSLEQWAAWLDGVVS ::::::::::::::::::::::::.:.: .::::: :::.:::::..:::::::::.:. NP_001 INQMLSDLNRVDFANVQEQASWVCQCDDNMVQRLETDFKMTLQQQSTLEQWAAWLDNVMM 520 530 540 550 560 570 840 850 860 870 880 890 pF1KE1 QVLKPYQGSAGFPKAAKLFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMYYLI :.::::.: .:::::. ::::::::::::::::::::::::::::::::::::::.::. NP_001 QALKPYEGRPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLV 580 590 600 610 620 630 900 910 920 930 940 950 pF1KE1 EHRVAQAKGETPIAVMGEFANLATSLNPLDPDKDEEEEEEEESEDELPQDISLAAGGESP ::::::: :::::::::::..: ....: . :::: : : : ..:: NP_001 EHRVAQATGETPIAVMGEFGDL-NAVSPGNLDKDEGSEVESEMDEELDDSSEPQAKREKT 640 650 660 670 680 690 960 970 pF1KE1 ALGPETLEPPAKLARTDARGLFVQALPSS NP_001 ELSQAFPVGCMQPVLETGVQPSLLNPIHSEHIVTSTQTIRQCSATGNTYTAV 700 710 720 730 740 >>NP_602304 (OMIM: 601337) transcription factor RFX3 iso (749 aa) initn: 2571 init1: 1360 opt: 2439 Z-score: 871.7 bits: 172.4 E(85289): 8.1e-42 Smith-Waterman score: 2636; 61.2% identity (82.3% similar) in 677 aa overlap (268-937:29-684) 240 250 260 270 280 290 pF1KE1 QQSVPVTQERSVVQATPQAPKPGPVQPLTVQGLQPVHVAQEVQQLQQVP-VPHVYSSQVQ : .: : : :.:::.: : : ::: .::: NP_602 MQTSETGSDTGSTVTLQTSVASQAAVPTQVVQQVPVQQQVQQVQTVQQVQHVYPAQVQ 10 20 30 40 50 300 310 320 330 340 350 pF1KE1 YVEGGDASYTASAIRSSTYSYPETPLYTQTASTSYYEAAGTATQVSTPATSQAVASSGSM ::::.:. :: .:::..:: : :: .:.:... .:... :...::.: ..:......:.. NP_602 YVEGSDTVYTNGAIRTTTYPYTETQMYSQNTGGNYFDTQGSSAQVTTVVSSHSMVGTGGI 60 70 80 90 100 110 360 370 380 390 400 410 pF1KE1 PMYVSGSQVVASSASTGAGASNSSGGGGSGGGGGGGGGGGGGGSGSTGGGGSGAGTYVIQ : :.:.:...:: :: :.. .:: . . :. .:. NP_602 QMGVTGGQLISSS------------------GGTYLIGNSMENSGHSVTHTTRASPATIE 120 130 140 150 160 420 430 440 450 460 470 pF1KE1 GGYMLGSASQSYS-HTTRASPATVQWLLDNYETAEGVSLPRSTLYCHYLLHCQEQKLEPV . . :.. : : . . .::::::::::::::::::::: ::: ::::.::.:: NP_602 MAIETLQKSDGLSTHRSSLLNSHLQWLLDNYETAEGVSLPRSTLYNHYLRHCQEHKLDPV 170 180 190 200 210 220 480 490 500 510 520 530 pF1KE1 NAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGLRIKASSPLLRLMEDQQHMAMRGQPFS :::::::::::.:::::::::::::::::::::.:.: .::: ::.::.:.:::: ::.. NP_602 NAASFGKLIRSIFMGLRTRRLGTRGNSKYHYYGIRVKPDSPLNRLQEDMQYMAMRQQPMQ 230 240 250 260 270 280 540 550 560 570 580 590 pF1KE1 QKQRLKPIQKMEGMTNG-VAVGQQPSTGLSD-ISAQVQQYQQFLDASRSLPDFTELDLQG :::: ::.::..:...: .. ::: .:.. . . :: :..::::::::.::.: :..... NP_602 QKQRYKPMQKVDGVADGFTGSGQQTGTSVEQTVIAQSQHHQQFLDASRALPEFGEVEISS 290 300 310 320 330 340 600 610 620 630 640 650 pF1KE1 KVLPEGVGPGDIKAFQVLYREHCEAIVDVMVNLQFTLVETLWKTFWRYNLSQPSEAPPLA ::.:. :::..: :::::::::.::.:::::.:.: ::.:::::. : :... .. NP_602 --LPDGTTFEDIKSLQSLYREHCEAILDVVVNLQFSLIEKLWQTFWRYSPSTPTDGTTIT 350 360 370 380 390 660 670 680 690 700 710 pF1KE1 VHD---EAEKRLPKAILVLLSKFEPVLQWTKHCDNVLYQGLVEILIPDVLRPIPSALTQA . : :.::::: :. : : : .:.: .::. .::.:::::::::::::::::::: NP_602 ESSNLSEIESRLPKAKLITLCKHESILKWMCNCDHGMYQALVEILIPDVLRPIPSALTQA 400 410 420 430 440 450 720 730 740 750 760 770 pF1KE1 IRNFAKSLESWLTHAMVNIPEEMLRVKVAAAGAFAQTLRRYTSLNHLAQAARAVLQNTAQ :::::::::.::..:: :::..:...::::..::::::::::::::::::::::::::.: NP_602 IRNFAKSLEGWLSNAMNNIPQRMIQTKVAAVSAFAQTLRRYTSLNHLAQAARAVLQNTSQ 460 470 480 490 500 510 780 790 800 810 820 830 pF1KE1 INQMLSDLNRVDFANVQEQASWVCRCEDRVVQRLEQDFKVTLQQQNSLEQWAAWLDGVVS ::::::::::::::::::::::::.:.: .::::: :::.:::::..:::::::::.:. NP_602 INQMLSDLNRVDFANVQEQASWVCQCDDNMVQRLETDFKMTLQQQSTLEQWAAWLDNVMM 520 530 540 550 560 570 840 850 860 870 880 890 pF1KE1 QVLKPYQGSAGFPKAAKLFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMYYLI :.::::.: .:::::. ::::::::::::::::::::::::::::::::::::::.::. NP_602 QALKPYEGRPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLV 580 590 600 610 620 630 900 910 920 930 940 950 pF1KE1 EHRVAQAKGETPIAVMGEFANLATSLNPLDPDKDEEEEEEEESEDELPQDISLAAGGESP ::::::: :::::::::::..: ....: . :::: : : : ..:: NP_602 EHRVAQATGETPIAVMGEFGDL-NAVSPGNLDKDEGSEVESEMDEELDDSSEPQAKREKT 640 650 660 670 680 690 960 970 pF1KE1 ALGPETLEPPAKLARTDARGLFVQALPSS NP_602 ELSQAFPVGCMQPVLETGVQPSLLNPIHSEHIVTSTQTIRQCSATGNTYTAV 700 710 720 730 740 979 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 07:28:00 2016 done: Sat Nov 5 07:28:03 2016 Total Scan time: 16.820 Total Display time: 0.330 Function used was FASTA [36.3.4 Apr, 2011]