FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1038, 672 aa 1>>>pF1KE1038 672 - 672 aa - 672 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.1638+/-0.000454; mu= 15.0101+/- 0.028 mean_var=79.6404+/-15.983, 0's: 0 Z-trim(110.7): 24 B-trim: 784 in 1/50 Lambda= 0.143717 statistics sampled from 19128 (19146) to 19128 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.585), E-opt: 0.2 (0.224), width: 16 Scan time: 11.200 The best scores are: opt bits E(85289) NP_060660 (OMIM: 607590,615984) Bardet-Biedl syndr ( 672) 4410 924.7 0 NP_789794 (OMIM: 607590,615984) Bardet-Biedl syndr ( 715) 4410 924.7 0 XP_005263163 (OMIM: 607590,615984) PREDICTED: Bard ( 716) 4398 922.2 0 XP_016863846 (OMIM: 607590,615984) PREDICTED: Bard ( 660) 3310 696.6 7.4e-200 XP_016863847 (OMIM: 607590,615984) PREDICTED: Bard ( 618) 3298 694.1 3.9e-199 XP_011530381 (OMIM: 607590,615984) PREDICTED: Bard ( 731) 3090 651.0 4.4e-186 XP_011530382 (OMIM: 607590,615984) PREDICTED: Bard ( 730) 3079 648.8 2.1e-185 XP_011530383 (OMIM: 607590,615984) PREDICTED: Bard ( 676) 1990 422.9 1.9e-117 >>NP_060660 (OMIM: 607590,615984) Bardet-Biedl syndrome (672 aa) initn: 4410 init1: 4410 opt: 4410 Z-score: 4941.5 bits: 924.7 E(85289): 0 Smith-Waterman score: 4410; 100.0% identity (100.0% similar) in 672 aa overlap (1-672:1-672) 10 20 30 40 50 60 pF1KE1 MDLILNRMDYLQVGVTSQKTMKLIPASRHRATQKVVIGDHDGVVMCFGMKKGEAAAVFKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 MDLILNRMDYLQVGVTSQKTMKLIPASRHRATQKVVIGDHDGVVMCFGMKKGEAAAVFKT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LPGPKIARLELGGVINTPQEKIFIAAASEIRGFTKRGKQFLSFETNLTESIKAMHISGSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 LPGPKIARLELGGVINTPQEKIFIAAASEIRGFTKRGKQFLSFETNLTESIKAMHISGSD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 LFLSASYIYNHYCDCKDQHYYLSGDKINDVICLPVERLSRITPVLACQDRVLRVLQGSDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 LFLSASYIYNHYCDCKDQHYYLSGDKINDVICLPVERLSRITPVLACQDRVLRVLQGSDV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 MYAVEVPGPPTVLALHNGNGGDSGEDLLFGTSDGKLALIQITTSKPVRKWEIQNEKKRGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 MYAVEVPGPPTVLALHNGNGGDSGEDLLFGTSDGKLALIQITTSKPVRKWEIQNEKKRGG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 ILCIDSFDIVGDGVKDLLVGRDDGMVEVYSFDNANEPVLRFDQMLSESVTSIQGGCVGKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 ILCIDSFDIVGDGVKDLLVGRDDGMVEVYSFDNANEPVLRFDQMLSESVTSIQGGCVGKD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 SYDEIVVSTYSGWVTGLTTEPIHKESGPGEELKINQEMQNKISSLRNELEHLQYKVLQER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 SYDEIVVSTYSGWVTGLTTEPIHKESGPGEELKINQEMQNKISSLRNELEHLQYKVLQER 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 ENYQQSSQSSKAKSAVPSFGINDKFTLNKDDASYSLILEVQTAIDNVLIQSDVPIDLLDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 ENYQQSSQSSKAKSAVPSFGINDKFTLNKDDASYSLILEVQTAIDNVLIQSDVPIDLLDV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 DKNSAVVSFSSCDSESNDNFLLATYRCQADTTRLELKIRSIEGQYGTLQAYVTPRIQPKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 DKNSAVVSFSSCDSESNDNFLLATYRCQADTTRLELKIRSIEGQYGTLQAYVTPRIQPKT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE1 CQVRQYHIKPLSLHQRTHFIDHDRPMNTLTLTGQFSFAEVHSWVVFCLPEVPEKPPAGEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 CQVRQYHIKPLSLHQRTHFIDHDRPMNTLTLTGQFSFAEVHSWVVFCLPEVPEKPPAGEC 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE1 VTFYFQNTFLDTQLESTYRKGEGVFKSDNISTISILKDVLSKEATKRKINLNISYEINEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 VTFYFQNTFLDTQLESTYRKGEGVFKSDNISTISILKDVLSKEATKRKINLNISYEINEV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE1 SVKHTLKLIHPKLEYQLLLAKKVQLIDALKELQIHEGNTNFLIPEYHCILEEADHLQEEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 SVKHTLKLIHPKLEYQLLLAKKVQLIDALKELQIHEGNTNFLIPEYHCILEEADHLQEEY 610 620 630 640 650 660 670 pF1KE1 KKQPAHLERLYG :::::::::::: NP_060 KKQPAHLERLYG 670 >>NP_789794 (OMIM: 607590,615984) Bardet-Biedl syndrome (715 aa) initn: 4410 init1: 4410 opt: 4410 Z-score: 4941.1 bits: 924.7 E(85289): 0 Smith-Waterman score: 4410; 100.0% identity (100.0% similar) in 672 aa overlap (1-672:1-672) 10 20 30 40 50 60 pF1KE1 MDLILNRMDYLQVGVTSQKTMKLIPASRHRATQKVVIGDHDGVVMCFGMKKGEAAAVFKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_789 MDLILNRMDYLQVGVTSQKTMKLIPASRHRATQKVVIGDHDGVVMCFGMKKGEAAAVFKT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LPGPKIARLELGGVINTPQEKIFIAAASEIRGFTKRGKQFLSFETNLTESIKAMHISGSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_789 LPGPKIARLELGGVINTPQEKIFIAAASEIRGFTKRGKQFLSFETNLTESIKAMHISGSD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 LFLSASYIYNHYCDCKDQHYYLSGDKINDVICLPVERLSRITPVLACQDRVLRVLQGSDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_789 LFLSASYIYNHYCDCKDQHYYLSGDKINDVICLPVERLSRITPVLACQDRVLRVLQGSDV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 MYAVEVPGPPTVLALHNGNGGDSGEDLLFGTSDGKLALIQITTSKPVRKWEIQNEKKRGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_789 MYAVEVPGPPTVLALHNGNGGDSGEDLLFGTSDGKLALIQITTSKPVRKWEIQNEKKRGG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 ILCIDSFDIVGDGVKDLLVGRDDGMVEVYSFDNANEPVLRFDQMLSESVTSIQGGCVGKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_789 ILCIDSFDIVGDGVKDLLVGRDDGMVEVYSFDNANEPVLRFDQMLSESVTSIQGGCVGKD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 SYDEIVVSTYSGWVTGLTTEPIHKESGPGEELKINQEMQNKISSLRNELEHLQYKVLQER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_789 SYDEIVVSTYSGWVTGLTTEPIHKESGPGEELKINQEMQNKISSLRNELEHLQYKVLQER 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 ENYQQSSQSSKAKSAVPSFGINDKFTLNKDDASYSLILEVQTAIDNVLIQSDVPIDLLDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_789 ENYQQSSQSSKAKSAVPSFGINDKFTLNKDDASYSLILEVQTAIDNVLIQSDVPIDLLDV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 DKNSAVVSFSSCDSESNDNFLLATYRCQADTTRLELKIRSIEGQYGTLQAYVTPRIQPKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_789 DKNSAVVSFSSCDSESNDNFLLATYRCQADTTRLELKIRSIEGQYGTLQAYVTPRIQPKT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE1 CQVRQYHIKPLSLHQRTHFIDHDRPMNTLTLTGQFSFAEVHSWVVFCLPEVPEKPPAGEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_789 CQVRQYHIKPLSLHQRTHFIDHDRPMNTLTLTGQFSFAEVHSWVVFCLPEVPEKPPAGEC 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE1 VTFYFQNTFLDTQLESTYRKGEGVFKSDNISTISILKDVLSKEATKRKINLNISYEINEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_789 VTFYFQNTFLDTQLESTYRKGEGVFKSDNISTISILKDVLSKEATKRKINLNISYEINEV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE1 SVKHTLKLIHPKLEYQLLLAKKVQLIDALKELQIHEGNTNFLIPEYHCILEEADHLQEEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_789 SVKHTLKLIHPKLEYQLLLAKKVQLIDALKELQIHEGNTNFLIPEYHCILEEADHLQEEY 610 620 630 640 650 660 670 pF1KE1 KKQPAHLERLYG :::::::::::: NP_789 KKQPAHLERLYGMITDLFIDKFKFKGTNVKTKVPLLLEILDSYDQNALISFFDAA 670 680 690 700 710 >>XP_005263163 (OMIM: 607590,615984) PREDICTED: Bardet-B (716 aa) initn: 4396 init1: 3087 opt: 4398 Z-score: 4927.6 bits: 922.2 E(85289): 0 Smith-Waterman score: 4398; 99.9% identity (99.9% similar) in 673 aa overlap (1-672:1-673) 10 20 30 40 50 60 pF1KE1 MDLILNRMDYLQVGVTSQKTMKLIPASRHRATQKVVIGDHDGVVMCFGMKKGEAAAVFKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MDLILNRMDYLQVGVTSQKTMKLIPASRHRATQKVVIGDHDGVVMCFGMKKGEAAAVFKT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LPGPKIARLELGGVINTPQEKIFIAAASEIRGFTKRGKQFLSFETNLTESIKAMHISGSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LPGPKIARLELGGVINTPQEKIFIAAASEIRGFTKRGKQFLSFETNLTESIKAMHISGSD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 LFLSASYIYNHYCDCKDQHYYLSGDKINDVICLPVERLSRITPVLACQDRVLRVLQGSDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LFLSASYIYNHYCDCKDQHYYLSGDKINDVICLPVERLSRITPVLACQDRVLRVLQGSDV 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 MYAVEVPGPPTVLALHNGNG-GDSGEDLLFGTSDGKLALIQITTSKPVRKWEIQNEKKRG :::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::: XP_005 MYAVEVPGPPTVLALHNGNGVGDSGEDLLFGTSDGKLALIQITTSKPVRKWEIQNEKKRG 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE1 GILCIDSFDIVGDGVKDLLVGRDDGMVEVYSFDNANEPVLRFDQMLSESVTSIQGGCVGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GILCIDSFDIVGDGVKDLLVGRDDGMVEVYSFDNANEPVLRFDQMLSESVTSIQGGCVGK 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE1 DSYDEIVVSTYSGWVTGLTTEPIHKESGPGEELKINQEMQNKISSLRNELEHLQYKVLQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DSYDEIVVSTYSGWVTGLTTEPIHKESGPGEELKINQEMQNKISSLRNELEHLQYKVLQE 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE1 RENYQQSSQSSKAKSAVPSFGINDKFTLNKDDASYSLILEVQTAIDNVLIQSDVPIDLLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RENYQQSSQSSKAKSAVPSFGINDKFTLNKDDASYSLILEVQTAIDNVLIQSDVPIDLLD 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE1 VDKNSAVVSFSSCDSESNDNFLLATYRCQADTTRLELKIRSIEGQYGTLQAYVTPRIQPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VDKNSAVVSFSSCDSESNDNFLLATYRCQADTTRLELKIRSIEGQYGTLQAYVTPRIQPK 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE1 TCQVRQYHIKPLSLHQRTHFIDHDRPMNTLTLTGQFSFAEVHSWVVFCLPEVPEKPPAGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TCQVRQYHIKPLSLHQRTHFIDHDRPMNTLTLTGQFSFAEVHSWVVFCLPEVPEKPPAGE 490 500 510 520 530 540 540 550 560 570 580 590 pF1KE1 CVTFYFQNTFLDTQLESTYRKGEGVFKSDNISTISILKDVLSKEATKRKINLNISYEINE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CVTFYFQNTFLDTQLESTYRKGEGVFKSDNISTISILKDVLSKEATKRKINLNISYEINE 550 560 570 580 590 600 600 610 620 630 640 650 pF1KE1 VSVKHTLKLIHPKLEYQLLLAKKVQLIDALKELQIHEGNTNFLIPEYHCILEEADHLQEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VSVKHTLKLIHPKLEYQLLLAKKVQLIDALKELQIHEGNTNFLIPEYHCILEEADHLQEE 610 620 630 640 650 660 660 670 pF1KE1 YKKQPAHLERLYG ::::::::::::: XP_005 YKKQPAHLERLYGMITDLFIDKFKFKGTNVKTKVPLLLEILDSYDQNALISFFDAA 670 680 690 700 710 >>XP_016863846 (OMIM: 607590,615984) PREDICTED: Bardet-B (660 aa) initn: 3310 init1: 3310 opt: 3310 Z-score: 3709.0 bits: 696.6 E(85289): 7.4e-200 Smith-Waterman score: 3906; 91.8% identity (91.8% similar) in 672 aa overlap (1-672:1-617) 10 20 30 40 50 60 pF1KE1 MDLILNRMDYLQVGVTSQKTMKLIPASRHRATQKVVIGDHDGVVMCFGMKKGEAAAVFKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MDLILNRMDYLQVGVTSQKTMKLIPASRHRATQKVVIGDHDGVVMCFGMKKGEAAAVFKT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LPGPKIARLELGGVINTPQEKIFIAAASEIRGFTKRGKQFLSFETNLTESIKAMHISGSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPGPKIARLELGGVINTPQEKIFIAAASEIRGFTKRGKQFLSFETNLTESIKAMHISGSD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 LFLSASYIYNHYCDCKDQHYYLSGDKINDVICLPVERLSRITPVLACQDRVLRVLQGSDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LFLSASYIYNHYCDCKDQHYYLSGDKINDVICLPVERLSRITPVLACQDRVLRVLQGSDV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 MYAVEVPGPPTVLALHNGNGGDSGEDLLFGTSDGKLALIQITTSKPVRKWEIQNEKKRGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MYAVEVPGPPTVLALHNGNGGDSGEDLLFGTSDGKLALIQITTSKPVRKWEIQNEKKRGG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 ILCIDSFDIVGDGVKDLLVGRDDGMVEVYSFDNANEPVLRFDQMLSESVTSIQGGCVGKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILCIDSFDIVGDGVKDLLVGRDDGMVEVYSFDNANEPVLRFDQMLSESVTSIQGGCVGKD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 SYDEIVVSTYSGWVTGLTTEPIHKESGPGEELKINQEMQNKISSLRNELEHLQYKVLQER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SYDEIVVSTYSGWVTGLTTEPIHKESGPGEELKINQEMQNKISSLRNELEHLQYKVLQER 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 ENYQQSSQSSKAKSAVPSFGINDKFTLNKDDASYSLILEVQTAIDNVLIQSDVPIDLLDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ENYQQSSQSSKAKSAVPSFGINDKFTLNKDDASYSLILEVQTAIDNVLIQSDVPIDLLDV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 DKNSAVVSFSSCDSESNDNFLLATYRCQADTTRLELKIRSIEGQYGTLQAYVTPRIQPKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DKNSAVVSFSSCDSESNDNFLLATYRCQADTTRLELKIRSIEGQYGTLQAYVTPRIQPKT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE1 CQVRQYHIKPLSLHQRTHFIDHDRPMNTLTLTGQFSFAEVHSWVVFCLPEVPEKPPAGEC :::::::::::::::::::::::: XP_016 CQVRQYHIKPLSLHQRTHFIDHDR------------------------------------ 490 500 550 560 570 580 590 600 pF1KE1 VTFYFQNTFLDTQLESTYRKGEGVFKSDNISTISILKDVLSKEATKRKINLNISYEINEV ::::::::::::::::::::::::::::::::::::::::: XP_016 -------------------KGEGVFKSDNISTISILKDVLSKEATKRKINLNISYEINEV 510 520 530 540 610 620 630 640 650 660 pF1KE1 SVKHTLKLIHPKLEYQLLLAKKVQLIDALKELQIHEGNTNFLIPEYHCILEEADHLQEEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVKHTLKLIHPKLEYQLLLAKKVQLIDALKELQIHEGNTNFLIPEYHCILEEADHLQEEY 550 560 570 580 590 600 670 pF1KE1 KKQPAHLERLYG :::::::::::: XP_016 KKQPAHLERLYGMITDLFIDKFKFKGTNVKTKVPLLLEILDSYDQNALISFFDAA 610 620 630 640 650 660 >>XP_016863847 (OMIM: 607590,615984) PREDICTED: Bardet-B (618 aa) initn: 3296 init1: 1987 opt: 3298 Z-score: 3696.0 bits: 694.1 E(85289): 3.9e-199 Smith-Waterman score: 3894; 91.7% identity (91.7% similar) in 673 aa overlap (1-672:1-618) 10 20 30 40 50 60 pF1KE1 MDLILNRMDYLQVGVTSQKTMKLIPASRHRATQKVVIGDHDGVVMCFGMKKGEAAAVFKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MDLILNRMDYLQVGVTSQKTMKLIPASRHRATQKVVIGDHDGVVMCFGMKKGEAAAVFKT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LPGPKIARLELGGVINTPQEKIFIAAASEIRGFTKRGKQFLSFETNLTESIKAMHISGSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPGPKIARLELGGVINTPQEKIFIAAASEIRGFTKRGKQFLSFETNLTESIKAMHISGSD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 LFLSASYIYNHYCDCKDQHYYLSGDKINDVICLPVERLSRITPVLACQDRVLRVLQGSDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LFLSASYIYNHYCDCKDQHYYLSGDKINDVICLPVERLSRITPVLACQDRVLRVLQGSDV 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 MYAVEVPGPPTVLALHNGNG-GDSGEDLLFGTSDGKLALIQITTSKPVRKWEIQNEKKRG :::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::: XP_016 MYAVEVPGPPTVLALHNGNGVGDSGEDLLFGTSDGKLALIQITTSKPVRKWEIQNEKKRG 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE1 GILCIDSFDIVGDGVKDLLVGRDDGMVEVYSFDNANEPVLRFDQMLSESVTSIQGGCVGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GILCIDSFDIVGDGVKDLLVGRDDGMVEVYSFDNANEPVLRFDQMLSESVTSIQGGCVGK 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE1 DSYDEIVVSTYSGWVTGLTTEPIHKESGPGEELKINQEMQNKISSLRNELEHLQYKVLQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DSYDEIVVSTYSGWVTGLTTEPIHKESGPGEELKINQEMQNKISSLRNELEHLQYKVLQE 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE1 RENYQQSSQSSKAKSAVPSFGINDKFTLNKDDASYSLILEVQTAIDNVLIQSDVPIDLLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RENYQQSSQSSKAKSAVPSFGINDKFTLNKDDASYSLILEVQTAIDNVLIQSDVPIDLLD 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE1 VDKNSAVVSFSSCDSESNDNFLLATYRCQADTTRLELKIRSIEGQYGTLQAYVTPRIQPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VDKNSAVVSFSSCDSESNDNFLLATYRCQADTTRLELKIRSIEGQYGTLQAYVTPRIQPK 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE1 TCQVRQYHIKPLSLHQRTHFIDHDRPMNTLTLTGQFSFAEVHSWVVFCLPEVPEKPPAGE ::::::::::::::::::::::::: XP_016 TCQVRQYHIKPLSLHQRTHFIDHDR----------------------------------- 490 500 540 550 560 570 580 590 pF1KE1 CVTFYFQNTFLDTQLESTYRKGEGVFKSDNISTISILKDVLSKEATKRKINLNISYEINE :::::::::::::::::::::::::::::::::::::::: XP_016 --------------------KGEGVFKSDNISTISILKDVLSKEATKRKINLNISYEINE 510 520 530 540 600 610 620 630 640 650 pF1KE1 VSVKHTLKLIHPKLEYQLLLAKKVQLIDALKELQIHEGNTNFLIPEYHCILEEADHLQEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VSVKHTLKLIHPKLEYQLLLAKKVQLIDALKELQIHEGNTNFLIPEYHCILEEADHLQEE 550 560 570 580 590 600 660 670 pF1KE1 YKKQPAHLERLYG ::::::::::::: XP_016 YKKQPAHLERLYG 610 >>XP_011530381 (OMIM: 607590,615984) PREDICTED: Bardet-B (731 aa) initn: 3090 init1: 3090 opt: 3090 Z-score: 3461.8 bits: 651.0 E(85289): 4.4e-186 Smith-Waterman score: 4368; 97.7% identity (97.7% similar) in 688 aa overlap (1-672:1-688) 10 20 30 40 50 60 pF1KE1 MDLILNRMDYLQVGVTSQKTMKLIPASRHRATQKVVIGDHDGVVMCFGMKKGEAAAVFKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MDLILNRMDYLQVGVTSQKTMKLIPASRHRATQKVVIGDHDGVVMCFGMKKGEAAAVFKT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LPGPKIARLELGGVINTPQEKIFIAAASEIRGFTKRGKQFLSFETNLTESIKAMHISGSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LPGPKIARLELGGVINTPQEKIFIAAASEIRGFTKRGKQFLSFETNLTESIKAMHISGSD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 LFLSASYIYNHYCDCKDQHYYLSGDKINDVICLPVERLSRITPVLACQDRVLRVLQGSDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LFLSASYIYNHYCDCKDQHYYLSGDKINDVICLPVERLSRITPVLACQDRVLRVLQGSDV 130 140 150 160 170 180 190 200 210 220 pF1KE1 MYAVEVPGPPTVLALHNGNGG----------------DSGEDLLFGTSDGKLALIQITTS ::::::::::::::::::::: ::::::::::::::::::::::: XP_011 MYAVEVPGPPTVLALHNGNGGNQDFIFHKSTMCFNIGDSGEDLLFGTSDGKLALIQITTS 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE1 KPVRKWEIQNEKKRGGILCIDSFDIVGDGVKDLLVGRDDGMVEVYSFDNANEPVLRFDQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KPVRKWEIQNEKKRGGILCIDSFDIVGDGVKDLLVGRDDGMVEVYSFDNANEPVLRFDQM 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE1 LSESVTSIQGGCVGKDSYDEIVVSTYSGWVTGLTTEPIHKESGPGEELKINQEMQNKISS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSESVTSIQGGCVGKDSYDEIVVSTYSGWVTGLTTEPIHKESGPGEELKINQEMQNKISS 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE1 LRNELEHLQYKVLQERENYQQSSQSSKAKSAVPSFGINDKFTLNKDDASYSLILEVQTAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRNELEHLQYKVLQERENYQQSSQSSKAKSAVPSFGINDKFTLNKDDASYSLILEVQTAI 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE1 DNVLIQSDVPIDLLDVDKNSAVVSFSSCDSESNDNFLLATYRCQADTTRLELKIRSIEGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DNVLIQSDVPIDLLDVDKNSAVVSFSSCDSESNDNFLLATYRCQADTTRLELKIRSIEGQ 430 440 450 460 470 480 470 480 490 500 510 520 pF1KE1 YGTLQAYVTPRIQPKTCQVRQYHIKPLSLHQRTHFIDHDRPMNTLTLTGQFSFAEVHSWV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YGTLQAYVTPRIQPKTCQVRQYHIKPLSLHQRTHFIDHDRPMNTLTLTGQFSFAEVHSWV 490 500 510 520 530 540 530 540 550 560 570 580 pF1KE1 VFCLPEVPEKPPAGECVTFYFQNTFLDTQLESTYRKGEGVFKSDNISTISILKDVLSKEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VFCLPEVPEKPPAGECVTFYFQNTFLDTQLESTYRKGEGVFKSDNISTISILKDVLSKEA 550 560 570 580 590 600 590 600 610 620 630 640 pF1KE1 TKRKINLNISYEINEVSVKHTLKLIHPKLEYQLLLAKKVQLIDALKELQIHEGNTNFLIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TKRKINLNISYEINEVSVKHTLKLIHPKLEYQLLLAKKVQLIDALKELQIHEGNTNFLIP 610 620 630 640 650 660 650 660 670 pF1KE1 EYHCILEEADHLQEEYKKQPAHLERLYG :::::::::::::::::::::::::::: XP_011 EYHCILEEADHLQEEYKKQPAHLERLYGMITDLFIDKFKFKGTNVKTKVPLLLEILDSYD 670 680 690 700 710 720 >>XP_011530382 (OMIM: 607590,615984) PREDICTED: Bardet-B (730 aa) initn: 3079 init1: 3079 opt: 3079 Z-score: 3449.5 bits: 648.8 E(85289): 2.1e-185 Smith-Waterman score: 4370; 97.8% identity (97.8% similar) in 687 aa overlap (1-672:1-687) 10 20 30 40 50 60 pF1KE1 MDLILNRMDYLQVGVTSQKTMKLIPASRHRATQKVVIGDHDGVVMCFGMKKGEAAAVFKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MDLILNRMDYLQVGVTSQKTMKLIPASRHRATQKVVIGDHDGVVMCFGMKKGEAAAVFKT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LPGPKIARLELGGVINTPQEKIFIAAASEIRGFTKRGKQFLSFETNLTESIKAMHISGSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LPGPKIARLELGGVINTPQEKIFIAAASEIRGFTKRGKQFLSFETNLTESIKAMHISGSD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 LFLSASYIYNHYCDCKDQHYYLSGDKINDVICLPVERLSRITPVLACQDRVLRVLQGSDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LFLSASYIYNHYCDCKDQHYYLSGDKINDVICLPVERLSRITPVLACQDRVLRVLQGSDV 130 140 150 160 170 180 190 200 210 220 pF1KE1 MYAVEVPGPPTVLALHNGNGG---------------DSGEDLLFGTSDGKLALIQITTSK ::::::::::::::::::::: :::::::::::::::::::::::: XP_011 MYAVEVPGPPTVLALHNGNGGNQDFIFHKSTMCFNSDSGEDLLFGTSDGKLALIQITTSK 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE1 PVRKWEIQNEKKRGGILCIDSFDIVGDGVKDLLVGRDDGMVEVYSFDNANEPVLRFDQML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PVRKWEIQNEKKRGGILCIDSFDIVGDGVKDLLVGRDDGMVEVYSFDNANEPVLRFDQML 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE1 SESVTSIQGGCVGKDSYDEIVVSTYSGWVTGLTTEPIHKESGPGEELKINQEMQNKISSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SESVTSIQGGCVGKDSYDEIVVSTYSGWVTGLTTEPIHKESGPGEELKINQEMQNKISSL 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE1 RNELEHLQYKVLQERENYQQSSQSSKAKSAVPSFGINDKFTLNKDDASYSLILEVQTAID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RNELEHLQYKVLQERENYQQSSQSSKAKSAVPSFGINDKFTLNKDDASYSLILEVQTAID 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE1 NVLIQSDVPIDLLDVDKNSAVVSFSSCDSESNDNFLLATYRCQADTTRLELKIRSIEGQY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NVLIQSDVPIDLLDVDKNSAVVSFSSCDSESNDNFLLATYRCQADTTRLELKIRSIEGQY 430 440 450 460 470 480 470 480 490 500 510 520 pF1KE1 GTLQAYVTPRIQPKTCQVRQYHIKPLSLHQRTHFIDHDRPMNTLTLTGQFSFAEVHSWVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GTLQAYVTPRIQPKTCQVRQYHIKPLSLHQRTHFIDHDRPMNTLTLTGQFSFAEVHSWVV 490 500 510 520 530 540 530 540 550 560 570 580 pF1KE1 FCLPEVPEKPPAGECVTFYFQNTFLDTQLESTYRKGEGVFKSDNISTISILKDVLSKEAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FCLPEVPEKPPAGECVTFYFQNTFLDTQLESTYRKGEGVFKSDNISTISILKDVLSKEAT 550 560 570 580 590 600 590 600 610 620 630 640 pF1KE1 KRKINLNISYEINEVSVKHTLKLIHPKLEYQLLLAKKVQLIDALKELQIHEGNTNFLIPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KRKINLNISYEINEVSVKHTLKLIHPKLEYQLLLAKKVQLIDALKELQIHEGNTNFLIPE 610 620 630 640 650 660 650 660 670 pF1KE1 YHCILEEADHLQEEYKKQPAHLERLYG ::::::::::::::::::::::::::: XP_011 YHCILEEADHLQEEYKKQPAHLERLYGMITDLFIDKFKFKGTNVKTKVPLLLEILDSYDQ 670 680 690 700 710 720 >>XP_011530383 (OMIM: 607590,615984) PREDICTED: Bardet-B (676 aa) initn: 2085 init1: 1990 opt: 1990 Z-score: 2229.7 bits: 422.9 E(85289): 1.9e-117 Smith-Waterman score: 3864; 89.7% identity (89.7% similar) in 688 aa overlap (1-672:1-633) 10 20 30 40 50 60 pF1KE1 MDLILNRMDYLQVGVTSQKTMKLIPASRHRATQKVVIGDHDGVVMCFGMKKGEAAAVFKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MDLILNRMDYLQVGVTSQKTMKLIPASRHRATQKVVIGDHDGVVMCFGMKKGEAAAVFKT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LPGPKIARLELGGVINTPQEKIFIAAASEIRGFTKRGKQFLSFETNLTESIKAMHISGSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LPGPKIARLELGGVINTPQEKIFIAAASEIRGFTKRGKQFLSFETNLTESIKAMHISGSD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 LFLSASYIYNHYCDCKDQHYYLSGDKINDVICLPVERLSRITPVLACQDRVLRVLQGSDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LFLSASYIYNHYCDCKDQHYYLSGDKINDVICLPVERLSRITPVLACQDRVLRVLQGSDV 130 140 150 160 170 180 190 200 210 220 pF1KE1 MYAVEVPGPPTVLALHNGNGG----------------DSGEDLLFGTSDGKLALIQITTS ::::::::::::::::::::: ::::::::::::::::::::::: XP_011 MYAVEVPGPPTVLALHNGNGGNQDFIFHKSTMCFNIGDSGEDLLFGTSDGKLALIQITTS 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE1 KPVRKWEIQNEKKRGGILCIDSFDIVGDGVKDLLVGRDDGMVEVYSFDNANEPVLRFDQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KPVRKWEIQNEKKRGGILCIDSFDIVGDGVKDLLVGRDDGMVEVYSFDNANEPVLRFDQM 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE1 LSESVTSIQGGCVGKDSYDEIVVSTYSGWVTGLTTEPIHKESGPGEELKINQEMQNKISS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSESVTSIQGGCVGKDSYDEIVVSTYSGWVTGLTTEPIHKESGPGEELKINQEMQNKISS 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE1 LRNELEHLQYKVLQERENYQQSSQSSKAKSAVPSFGINDKFTLNKDDASYSLILEVQTAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRNELEHLQYKVLQERENYQQSSQSSKAKSAVPSFGINDKFTLNKDDASYSLILEVQTAI 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE1 DNVLIQSDVPIDLLDVDKNSAVVSFSSCDSESNDNFLLATYRCQADTTRLELKIRSIEGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DNVLIQSDVPIDLLDVDKNSAVVSFSSCDSESNDNFLLATYRCQADTTRLELKIRSIEGQ 430 440 450 460 470 480 470 480 490 500 510 520 pF1KE1 YGTLQAYVTPRIQPKTCQVRQYHIKPLSLHQRTHFIDHDRPMNTLTLTGQFSFAEVHSWV :::::::::::::::::::::::::::::::::::::::: XP_011 YGTLQAYVTPRIQPKTCQVRQYHIKPLSLHQRTHFIDHDR-------------------- 490 500 510 520 530 540 550 560 570 580 pF1KE1 VFCLPEVPEKPPAGECVTFYFQNTFLDTQLESTYRKGEGVFKSDNISTISILKDVLSKEA ::::::::::::::::::::::::: XP_011 -----------------------------------KGEGVFKSDNISTISILKDVLSKEA 530 540 590 600 610 620 630 640 pF1KE1 TKRKINLNISYEINEVSVKHTLKLIHPKLEYQLLLAKKVQLIDALKELQIHEGNTNFLIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TKRKINLNISYEINEVSVKHTLKLIHPKLEYQLLLAKKVQLIDALKELQIHEGNTNFLIP 550 560 570 580 590 600 650 660 670 pF1KE1 EYHCILEEADHLQEEYKKQPAHLERLYG :::::::::::::::::::::::::::: XP_011 EYHCILEEADHLQEEYKKQPAHLERLYGMITDLFIDKFKFKGTNVKTKVPLLLEILDSYD 610 620 630 640 650 660 672 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 07:41:52 2016 done: Sat Nov 5 07:41:53 2016 Total Scan time: 11.200 Total Display time: 0.150 Function used was FASTA [36.3.4 Apr, 2011]