FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1041, 350 aa 1>>>pF1KE1041 350 - 350 aa - 350 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3029+/-0.000369; mu= 16.8602+/- 0.023 mean_var=82.1566+/-16.456, 0's: 0 Z-trim(114.8): 236 B-trim: 0 in 0/50 Lambda= 0.141499 statistics sampled from 24659 (24900) to 24659 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.67), E-opt: 0.2 (0.292), width: 16 Scan time: 7.760 The best scores are: opt bits E(85289) XP_011517964 (OMIM: 606503) PREDICTED: histone-lys ( 350) 2433 506.4 3.8e-143 XP_016872126 (OMIM: 606503) PREDICTED: histone-lys ( 350) 2433 506.4 3.8e-143 XP_006717566 (OMIM: 606503) PREDICTED: histone-lys ( 350) 2433 506.4 3.8e-143 NP_078946 (OMIM: 606503) histone-lysine N-methyltr ( 350) 2433 506.4 3.8e-143 NP_001180354 (OMIM: 606503) histone-lysine N-methy ( 350) 2433 506.4 3.8e-143 NP_001180353 (OMIM: 606503) histone-lysine N-methy ( 410) 2433 506.5 4.3e-143 NP_003164 (OMIM: 300254) histone-lysine N-methyltr ( 412) 1398 295.2 1.7e-79 NP_001269095 (OMIM: 300254) histone-lysine N-methy ( 423) 1398 295.2 1.7e-79 NP_001180356 (OMIM: 606503) histone-lysine N-methy ( 170) 864 185.8 5.8e-47 NP_001180355 (OMIM: 606503) histone-lysine N-methy ( 230) 864 186.0 7.2e-47 NP_001305762 (OMIM: 604599) histone-lysine N-methy (1008) 535 119.3 3.6e-26 NP_079532 (OMIM: 604599) histone-lysine N-methyltr (1176) 535 119.4 4.1e-26 XP_016865691 (OMIM: 604599) PREDICTED: histone-lys (1183) 535 119.4 4.1e-26 NP_006700 (OMIM: 604599) histone-lysine N-methyltr (1210) 535 119.4 4.1e-26 XP_006715039 (OMIM: 604599) PREDICTED: histone-lys (1217) 535 119.4 4.2e-26 NP_001276342 (OMIM: 604599) histone-lysine N-methy (1233) 535 119.4 4.2e-26 XP_006715038 (OMIM: 604599) PREDICTED: histone-lys (1240) 535 119.4 4.2e-26 XP_005248881 (OMIM: 604599) PREDICTED: histone-lys (1267) 535 119.4 4.3e-26 XP_006715037 (OMIM: 604599) PREDICTED: histone-lys (1274) 535 119.4 4.3e-26 XP_011517333 (OMIM: 607001,610253) PREDICTED: hist ( 488) 513 114.6 4.7e-25 XP_011517332 (OMIM: 607001,610253) PREDICTED: hist ( 559) 513 114.6 5.2e-25 XP_011517331 (OMIM: 607001,610253) PREDICTED: hist ( 775) 513 114.7 6.7e-25 XP_011517335 (OMIM: 607001,610253) PREDICTED: hist (1246) 513 114.9 9.5e-25 XP_011517328 (OMIM: 607001,610253) PREDICTED: hist (1253) 513 114.9 9.6e-25 XP_016870626 (OMIM: 607001,610253) PREDICTED: hist (1260) 513 114.9 9.6e-25 XP_016870627 (OMIM: 607001,610253) PREDICTED: hist (1260) 513 114.9 9.6e-25 XP_016870625 (OMIM: 607001,610253) PREDICTED: hist (1265) 513 114.9 9.6e-25 XP_005266167 (OMIM: 607001,610253) PREDICTED: hist (1267) 513 114.9 9.7e-25 XP_011517327 (OMIM: 607001,610253) PREDICTED: hist (1267) 513 114.9 9.7e-25 XP_011517326 (OMIM: 607001,610253) PREDICTED: hist (1275) 513 114.9 9.7e-25 XP_016870624 (OMIM: 607001,610253) PREDICTED: hist (1291) 513 114.9 9.8e-25 XP_006717351 (OMIM: 607001,610253) PREDICTED: hist (1292) 513 114.9 9.8e-25 XP_016870623 (OMIM: 607001,610253) PREDICTED: hist (1293) 513 114.9 9.8e-25 XP_011517325 (OMIM: 607001,610253) PREDICTED: hist (1294) 513 114.9 9.8e-25 XP_005266162 (OMIM: 607001,610253) PREDICTED: hist (1295) 513 114.9 9.8e-25 NP_079033 (OMIM: 607001,610253) histone-lysine N-m (1298) 513 114.9 9.8e-25 XP_011517324 (OMIM: 607001,610253) PREDICTED: hist (1300) 513 114.9 9.8e-25 XP_011517323 (OMIM: 607001,610253) PREDICTED: hist (1301) 513 114.9 9.9e-25 NP_001263254 (OMIM: 609834) histone-lysine N-methy ( 365) 483 108.3 2.6e-23 NP_006506 (OMIM: 609834) histone-lysine N-methyltr ( 684) 483 108.6 4.2e-23 XP_016879841 (OMIM: 601674) PREDICTED: histone-lys ( 410) 324 75.9 1.7e-13 XP_016867310 (OMIM: 277590,601573) PREDICTED: hist ( 637) 326 76.5 1.8e-13 XP_011514200 (OMIM: 277590,601573) PREDICTED: hist ( 642) 326 76.5 1.8e-13 XP_011514199 (OMIM: 277590,601573) PREDICTED: hist ( 642) 326 76.5 1.8e-13 XP_011514198 (OMIM: 277590,601573) PREDICTED: hist ( 673) 326 76.5 1.9e-13 NP_001190178 (OMIM: 277590,601573) histone-lysine ( 695) 326 76.5 1.9e-13 XP_005250021 (OMIM: 277590,601573) PREDICTED: hist ( 703) 326 76.5 1.9e-13 XP_016867309 (OMIM: 277590,601573) PREDICTED: hist ( 703) 326 76.5 1.9e-13 NP_694543 (OMIM: 277590,601573) histone-lysine N-m ( 707) 326 76.5 1.9e-13 XP_011514197 (OMIM: 277590,601573) PREDICTED: hist ( 711) 326 76.5 1.9e-13 >>XP_011517964 (OMIM: 606503) PREDICTED: histone-lysine (350 aa) initn: 2433 init1: 2433 opt: 2433 Z-score: 2691.0 bits: 506.4 E(85289): 3.8e-143 Smith-Waterman score: 2433; 100.0% identity (100.0% similar) in 350 aa overlap (1-350:1-350) 10 20 30 40 50 60 pF1KE1 MEYYLVKWKGWPDSTNTWEPLQNLKCPLLLQQFSNDKHNYLSQVKKGKAITPKDNNKTLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MEYYLVKWKGWPDSTNTWEPLQNLKCPLLLQQFSNDKHNYLSQVKKGKAITPKDNNKTLK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 PAIAEYIVKKAKQRIALQRWQDELNRRKNHKGMIFVENTVDLEGPPSDFYYINEYKPAPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PAIAEYIVKKAKQRIALQRWQDELNRRKNHKGMIFVENTVDLEGPPSDFYYINEYKPAPG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 ISLVNEATFGCSCTDCFFQKCCPAEAGVLLAYNKNQQIKIPPGTPIYECNSRCQCGPDCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ISLVNEATFGCSCTDCFFQKCCPAEAGVLLAYNKNQQIKIPPGTPIYECNSRCQCGPDCP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 NRIVQKGTQYSLCIFRTSNGRGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NRIVQKGTQYSLCIFRTSNGRGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 GITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTR 250 260 270 280 290 300 310 320 330 340 350 pF1KE1 TINAGEELTFDYQMKGSGDISSDSIDHSPAKKRVRTVCKCGAVTCRGYLN :::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TINAGEELTFDYQMKGSGDISSDSIDHSPAKKRVRTVCKCGAVTCRGYLN 310 320 330 340 350 >>XP_016872126 (OMIM: 606503) PREDICTED: histone-lysine (350 aa) initn: 2433 init1: 2433 opt: 2433 Z-score: 2691.0 bits: 506.4 E(85289): 3.8e-143 Smith-Waterman score: 2433; 100.0% identity (100.0% similar) in 350 aa overlap (1-350:1-350) 10 20 30 40 50 60 pF1KE1 MEYYLVKWKGWPDSTNTWEPLQNLKCPLLLQQFSNDKHNYLSQVKKGKAITPKDNNKTLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MEYYLVKWKGWPDSTNTWEPLQNLKCPLLLQQFSNDKHNYLSQVKKGKAITPKDNNKTLK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 PAIAEYIVKKAKQRIALQRWQDELNRRKNHKGMIFVENTVDLEGPPSDFYYINEYKPAPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PAIAEYIVKKAKQRIALQRWQDELNRRKNHKGMIFVENTVDLEGPPSDFYYINEYKPAPG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 ISLVNEATFGCSCTDCFFQKCCPAEAGVLLAYNKNQQIKIPPGTPIYECNSRCQCGPDCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISLVNEATFGCSCTDCFFQKCCPAEAGVLLAYNKNQQIKIPPGTPIYECNSRCQCGPDCP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 NRIVQKGTQYSLCIFRTSNGRGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NRIVQKGTQYSLCIFRTSNGRGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 GITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTR 250 260 270 280 290 300 310 320 330 340 350 pF1KE1 TINAGEELTFDYQMKGSGDISSDSIDHSPAKKRVRTVCKCGAVTCRGYLN :::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TINAGEELTFDYQMKGSGDISSDSIDHSPAKKRVRTVCKCGAVTCRGYLN 310 320 330 340 350 >>XP_006717566 (OMIM: 606503) PREDICTED: histone-lysine (350 aa) initn: 2433 init1: 2433 opt: 2433 Z-score: 2691.0 bits: 506.4 E(85289): 3.8e-143 Smith-Waterman score: 2433; 100.0% identity (100.0% similar) in 350 aa overlap (1-350:1-350) 10 20 30 40 50 60 pF1KE1 MEYYLVKWKGWPDSTNTWEPLQNLKCPLLLQQFSNDKHNYLSQVKKGKAITPKDNNKTLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MEYYLVKWKGWPDSTNTWEPLQNLKCPLLLQQFSNDKHNYLSQVKKGKAITPKDNNKTLK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 PAIAEYIVKKAKQRIALQRWQDELNRRKNHKGMIFVENTVDLEGPPSDFYYINEYKPAPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PAIAEYIVKKAKQRIALQRWQDELNRRKNHKGMIFVENTVDLEGPPSDFYYINEYKPAPG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 ISLVNEATFGCSCTDCFFQKCCPAEAGVLLAYNKNQQIKIPPGTPIYECNSRCQCGPDCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ISLVNEATFGCSCTDCFFQKCCPAEAGVLLAYNKNQQIKIPPGTPIYECNSRCQCGPDCP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 NRIVQKGTQYSLCIFRTSNGRGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NRIVQKGTQYSLCIFRTSNGRGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 GITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTR 250 260 270 280 290 300 310 320 330 340 350 pF1KE1 TINAGEELTFDYQMKGSGDISSDSIDHSPAKKRVRTVCKCGAVTCRGYLN :::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TINAGEELTFDYQMKGSGDISSDSIDHSPAKKRVRTVCKCGAVTCRGYLN 310 320 330 340 350 >>NP_078946 (OMIM: 606503) histone-lysine N-methyltransf (350 aa) initn: 2433 init1: 2433 opt: 2433 Z-score: 2691.0 bits: 506.4 E(85289): 3.8e-143 Smith-Waterman score: 2433; 100.0% identity (100.0% similar) in 350 aa overlap (1-350:1-350) 10 20 30 40 50 60 pF1KE1 MEYYLVKWKGWPDSTNTWEPLQNLKCPLLLQQFSNDKHNYLSQVKKGKAITPKDNNKTLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 MEYYLVKWKGWPDSTNTWEPLQNLKCPLLLQQFSNDKHNYLSQVKKGKAITPKDNNKTLK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 PAIAEYIVKKAKQRIALQRWQDELNRRKNHKGMIFVENTVDLEGPPSDFYYINEYKPAPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 PAIAEYIVKKAKQRIALQRWQDELNRRKNHKGMIFVENTVDLEGPPSDFYYINEYKPAPG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 ISLVNEATFGCSCTDCFFQKCCPAEAGVLLAYNKNQQIKIPPGTPIYECNSRCQCGPDCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 ISLVNEATFGCSCTDCFFQKCCPAEAGVLLAYNKNQQIKIPPGTPIYECNSRCQCGPDCP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 NRIVQKGTQYSLCIFRTSNGRGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 NRIVQKGTQYSLCIFRTSNGRGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 GITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 GITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTR 250 260 270 280 290 300 310 320 330 340 350 pF1KE1 TINAGEELTFDYQMKGSGDISSDSIDHSPAKKRVRTVCKCGAVTCRGYLN :::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 TINAGEELTFDYQMKGSGDISSDSIDHSPAKKRVRTVCKCGAVTCRGYLN 310 320 330 340 350 >>NP_001180354 (OMIM: 606503) histone-lysine N-methyltra (350 aa) initn: 2433 init1: 2433 opt: 2433 Z-score: 2691.0 bits: 506.4 E(85289): 3.8e-143 Smith-Waterman score: 2433; 100.0% identity (100.0% similar) in 350 aa overlap (1-350:1-350) 10 20 30 40 50 60 pF1KE1 MEYYLVKWKGWPDSTNTWEPLQNLKCPLLLQQFSNDKHNYLSQVKKGKAITPKDNNKTLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEYYLVKWKGWPDSTNTWEPLQNLKCPLLLQQFSNDKHNYLSQVKKGKAITPKDNNKTLK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 PAIAEYIVKKAKQRIALQRWQDELNRRKNHKGMIFVENTVDLEGPPSDFYYINEYKPAPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PAIAEYIVKKAKQRIALQRWQDELNRRKNHKGMIFVENTVDLEGPPSDFYYINEYKPAPG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 ISLVNEATFGCSCTDCFFQKCCPAEAGVLLAYNKNQQIKIPPGTPIYECNSRCQCGPDCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ISLVNEATFGCSCTDCFFQKCCPAEAGVLLAYNKNQQIKIPPGTPIYECNSRCQCGPDCP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 NRIVQKGTQYSLCIFRTSNGRGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NRIVQKGTQYSLCIFRTSNGRGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 GITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTR 250 260 270 280 290 300 310 320 330 340 350 pF1KE1 TINAGEELTFDYQMKGSGDISSDSIDHSPAKKRVRTVCKCGAVTCRGYLN :::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TINAGEELTFDYQMKGSGDISSDSIDHSPAKKRVRTVCKCGAVTCRGYLN 310 320 330 340 350 >>NP_001180353 (OMIM: 606503) histone-lysine N-methyltra (410 aa) initn: 2433 init1: 2433 opt: 2433 Z-score: 2690.0 bits: 506.5 E(85289): 4.3e-143 Smith-Waterman score: 2433; 100.0% identity (100.0% similar) in 350 aa overlap (1-350:61-410) 10 20 30 pF1KE1 MEYYLVKWKGWPDSTNTWEPLQNLKCPLLL :::::::::::::::::::::::::::::: NP_001 KLTCKSIGITKRNLNNYEVEYLCDYKVVKDMEYYLVKWKGWPDSTNTWEPLQNLKCPLLL 40 50 60 70 80 90 40 50 60 70 80 90 pF1KE1 QQFSNDKHNYLSQVKKGKAITPKDNNKTLKPAIAEYIVKKAKQRIALQRWQDELNRRKNH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QQFSNDKHNYLSQVKKGKAITPKDNNKTLKPAIAEYIVKKAKQRIALQRWQDELNRRKNH 100 110 120 130 140 150 100 110 120 130 140 150 pF1KE1 KGMIFVENTVDLEGPPSDFYYINEYKPAPGISLVNEATFGCSCTDCFFQKCCPAEAGVLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KGMIFVENTVDLEGPPSDFYYINEYKPAPGISLVNEATFGCSCTDCFFQKCCPAEAGVLL 160 170 180 190 200 210 160 170 180 190 200 210 pF1KE1 AYNKNQQIKIPPGTPIYECNSRCQCGPDCPNRIVQKGTQYSLCIFRTSNGRGWGVKTLVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AYNKNQQIKIPPGTPIYECNSRCQCGPDCPNRIVQKGTQYSLCIFRTSNGRGWGVKTLVK 220 230 240 250 260 270 220 230 240 250 260 270 pF1KE1 IKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDYESDEFTVDAARYGNVSHFVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDYESDEFTVDAARYGNVSHFVN 280 290 300 310 320 330 280 290 300 310 320 330 pF1KE1 HSCDPNLQVFNVFIDNLDTRLPRIALFSTRTINAGEELTFDYQMKGSGDISSDSIDHSPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HSCDPNLQVFNVFIDNLDTRLPRIALFSTRTINAGEELTFDYQMKGSGDISSDSIDHSPA 340 350 360 370 380 390 340 350 pF1KE1 KKRVRTVCKCGAVTCRGYLN :::::::::::::::::::: NP_001 KKRVRTVCKCGAVTCRGYLN 400 410 >>NP_003164 (OMIM: 300254) histone-lysine N-methyltransf (412 aa) initn: 1429 init1: 925 opt: 1398 Z-score: 1548.1 bits: 295.2 E(85289): 1.7e-79 Smith-Waterman score: 1466; 60.1% identity (77.8% similar) in 361 aa overlap (2-349:58-411) 10 20 30 pF1KE1 MEYYLVKWKGWPDSTNTWEPLQNLKCPLLLQ :::::::.:.::: .:::: ::::: .:. NP_003 LSCPALGISKRNLYDFEVEYLCDYKKIREQEYYLVKWRGYPDSESTWEPRQNLKCVRILK 30 40 50 60 70 80 40 50 60 70 80 90 pF1KE1 QFSNDKHNYLSQVKKGKAITPKDNNKTLKPAIAEYIVKKAKQRIALQRWQDELNRRKNHK :: .: . : . .. .. ::. : :..:.:.:.::::: ::.::..::: ...: NP_003 QFHKDLERELLR-RHHRSKTPRH----LDPSLANYLVQKAKQRRALRRWEQELNAKRSHL 90 100 110 120 130 140 100 110 120 130 140 pF1KE1 GMIFVENTVDLEGPPSDFYYINEYKPAPGISLVNEATFGCSCTDCFFQK---CCPAEAGV : : ::: :::.::: : :::::. . ::.: :... :: : ::.. :::. . NP_003 GRITVENEVDLDGPPRAFVYINEYRVGEGITL-NQVAVGCECQDCLWAPTGGCCPGASLH 150 160 170 180 190 200 150 160 170 180 190 200 pF1KE1 LLAYNKNQQIKIPPGTPIYECNSRCQCGPDCPNRIVQKGTQYSLCIFRTSNGRGWGVKTL .::: . :... : :::::::::.:: :::::.:::: .:.::::::..::::::.:: NP_003 KFAYNDQGQVRLRAGLPIYECNSRCRCGYDCPNRVVQKGIRYDLCIFRTDDGRGWGVRTL 210 220 230 240 250 260 210 220 230 240 250 260 pF1KE1 VKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDYESDEFTVDAARYGNVSHF ::.. :::::::::.:::::::::::.:: .: :::::::: : .::::: :::.::: NP_003 EKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVEDVYTVDAAYYGNISHF 270 280 290 300 310 320 270 280 290 300 310 320 pF1KE1 VNHSCDPNLQVFNVFIDNLDTRLPRIALFSTRTINAGEELTFDYQMKGSG-DISSDSIDH :::::::::::.:::::::: ::::::.:.:::: :::::::::.:. . :. : .: NP_003 VNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIRAGEELTFDYNMQVDPVDMESTRMDS 330 340 350 360 370 380 330 340 350 pF1KE1 ---------SPAKKRVRTVCKCGAVTCRGYLN :: ::::: ::::. .:: :: NP_003 NFGLAGLPGSP-KKRVRIECKCGTESCRKYLF 390 400 410 >>NP_001269095 (OMIM: 300254) histone-lysine N-methyltra (423 aa) initn: 1429 init1: 925 opt: 1398 Z-score: 1548.0 bits: 295.2 E(85289): 1.7e-79 Smith-Waterman score: 1466; 60.1% identity (77.8% similar) in 361 aa overlap (2-349:69-422) 10 20 30 pF1KE1 MEYYLVKWKGWPDSTNTWEPLQNLKCPLLLQ :::::::.:.::: .:::: ::::: .:. NP_001 LSCPALGISKRNLYDFEVEYLCDYKKIREQEYYLVKWRGYPDSESTWEPRQNLKCVRILK 40 50 60 70 80 90 40 50 60 70 80 90 pF1KE1 QFSNDKHNYLSQVKKGKAITPKDNNKTLKPAIAEYIVKKAKQRIALQRWQDELNRRKNHK :: .: . : . .. .. ::. : :..:.:.:.::::: ::.::..::: ...: NP_001 QFHKDLERELLR-RHHRSKTPRH----LDPSLANYLVQKAKQRRALRRWEQELNAKRSHL 100 110 120 130 140 150 100 110 120 130 140 pF1KE1 GMIFVENTVDLEGPPSDFYYINEYKPAPGISLVNEATFGCSCTDCFFQK---CCPAEAGV : : ::: :::.::: : :::::. . ::.: :... :: : ::.. :::. . NP_001 GRITVENEVDLDGPPRAFVYINEYRVGEGITL-NQVAVGCECQDCLWAPTGGCCPGASLH 160 170 180 190 200 210 150 160 170 180 190 200 pF1KE1 LLAYNKNQQIKIPPGTPIYECNSRCQCGPDCPNRIVQKGTQYSLCIFRTSNGRGWGVKTL .::: . :... : :::::::::.:: :::::.:::: .:.::::::..::::::.:: NP_001 KFAYNDQGQVRLRAGLPIYECNSRCRCGYDCPNRVVQKGIRYDLCIFRTDDGRGWGVRTL 220 230 240 250 260 270 210 220 230 240 250 260 pF1KE1 VKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDYESDEFTVDAARYGNVSHF ::.. :::::::::.:::::::::::.:: .: :::::::: : .::::: :::.::: NP_001 EKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVEDVYTVDAAYYGNISHF 280 290 300 310 320 330 270 280 290 300 310 320 pF1KE1 VNHSCDPNLQVFNVFIDNLDTRLPRIALFSTRTINAGEELTFDYQMKGSG-DISSDSIDH :::::::::::.:::::::: ::::::.:.:::: :::::::::.:. . :. : .: NP_001 VNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIRAGEELTFDYNMQVDPVDMESTRMDS 340 350 360 370 380 390 330 340 350 pF1KE1 ---------SPAKKRVRTVCKCGAVTCRGYLN :: ::::: ::::. .:: :: NP_001 NFGLAGLPGSP-KKRVRIECKCGTESCRKYLF 400 410 420 >>NP_001180356 (OMIM: 606503) histone-lysine N-methyltra (170 aa) initn: 864 init1: 864 opt: 864 Z-score: 964.2 bits: 185.8 E(85289): 5.8e-47 Smith-Waterman score: 864; 97.7% identity (100.0% similar) in 131 aa overlap (220-350:40-170) 190 200 210 220 230 240 pF1KE1 YSLCIFRTSNGRGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLD :...:::::::::::::::::::::::::: NP_001 GWPDSTNTWEPLQNLKCPLLLQQFSNDKHNYLSQVITSEEAERRGQFYDNKGITYLFDLD 10 20 30 40 50 60 250 260 270 280 290 300 pF1KE1 YESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTRTINAGEELT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTRTINAGEELT 70 80 90 100 110 120 310 320 330 340 350 pF1KE1 FDYQMKGSGDISSDSIDHSPAKKRVRTVCKCGAVTCRGYLN ::::::::::::::::::::::::::::::::::::::::: NP_001 FDYQMKGSGDISSDSIDHSPAKKRVRTVCKCGAVTCRGYLN 130 140 150 160 170 >-- initn: 293 init1: 293 opt: 293 Z-score: 334.2 bits: 69.3 E(85289): 7.1e-12 Smith-Waterman score: 293; 100.0% identity (100.0% similar) in 39 aa overlap (1-39:1-39) 10 20 30 40 50 60 pF1KE1 MEYYLVKWKGWPDSTNTWEPLQNLKCPLLLQQFSNDKHNYLSQVKKGKAITPKDNNKTLK ::::::::::::::::::::::::::::::::::::::: NP_001 MEYYLVKWKGWPDSTNTWEPLQNLKCPLLLQQFSNDKHNYLSQVITSEEAERRGQFYDNK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 PAIAEYIVKKAKQRIALQRWQDELNRRKNHKGMIFVENTVDLEGPPSDFYYINEYKPAPG NP_001 GITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTR 70 80 90 100 110 120 >>NP_001180355 (OMIM: 606503) histone-lysine N-methyltra (230 aa) initn: 864 init1: 864 opt: 864 Z-score: 962.4 bits: 186.0 E(85289): 7.2e-47 Smith-Waterman score: 864; 97.7% identity (100.0% similar) in 131 aa overlap (220-350:100-230) 190 200 210 220 230 240 pF1KE1 YSLCIFRTSNGRGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLD :...:::::::::::::::::::::::::: NP_001 GWPDSTNTWEPLQNLKCPLLLQQFSNDKHNYLSQVITSEEAERRGQFYDNKGITYLFDLD 70 80 90 100 110 120 250 260 270 280 290 300 pF1KE1 YESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTRTINAGEELT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTRTINAGEELT 130 140 150 160 170 180 310 320 330 340 350 pF1KE1 FDYQMKGSGDISSDSIDHSPAKKRVRTVCKCGAVTCRGYLN ::::::::::::::::::::::::::::::::::::::::: NP_001 FDYQMKGSGDISSDSIDHSPAKKRVRTVCKCGAVTCRGYLN 190 200 210 220 230 >-- initn: 293 init1: 293 opt: 293 Z-score: 332.4 bits: 69.4 E(85289): 8.9e-12 Smith-Waterman score: 293; 100.0% identity (100.0% similar) in 39 aa overlap (1-39:61-99) 10 20 30 pF1KE1 MEYYLVKWKGWPDSTNTWEPLQNLKCPLLL :::::::::::::::::::::::::::::: NP_001 KLTCKSIGITKRNLNNYEVEYLCDYKVVKDMEYYLVKWKGWPDSTNTWEPLQNLKCPLLL 40 50 60 70 80 90 40 50 60 70 80 90 pF1KE1 QQFSNDKHNYLSQVKKGKAITPKDNNKTLKPAIAEYIVKKAKQRIALQRWQDELNRRKNH ::::::::: NP_001 QQFSNDKHNYLSQVITSEEAERRGQFYDNKGITYLFDLDYESDEFTVDAARYGNVSHFVN 100 110 120 130 140 150 350 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 07:43:42 2016 done: Sat Nov 5 07:43:44 2016 Total Scan time: 7.760 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]