FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1044, 582 aa 1>>>pF1KE1044 582 - 582 aa - 582 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.2370+/-0.000334; mu= 6.9651+/- 0.021 mean_var=213.4481+/-47.286, 0's: 0 Z-trim(120.8): 60 B-trim: 0 in 0/59 Lambda= 0.087787 statistics sampled from 36486 (36555) to 36486 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.759), E-opt: 0.2 (0.429), width: 16 Scan time: 12.360 The best scores are: opt bits E(85289) NP_001137378 (OMIM: 613197) TRAF-type zinc finger ( 582) 4042 524.8 3e-148 NP_006691 (OMIM: 613197) TRAF-type zinc finger dom ( 582) 4042 524.8 3e-148 NP_059993 (OMIM: 606717) XIAP-associated factor 1 ( 301) 423 66.2 1.8e-10 XP_005256763 (OMIM: 606717) PREDICTED: XIAP-associ ( 256) 267 46.4 0.00014 NP_954590 (OMIM: 606717) XIAP-associated factor 1 ( 282) 265 46.2 0.00018 XP_011522249 (OMIM: 606717) PREDICTED: XIAP-associ ( 307) 237 42.7 0.0022 XP_011522250 (OMIM: 606717) PREDICTED: XIAP-associ ( 243) 235 42.3 0.0022 XP_011522248 (OMIM: 606717) PREDICTED: XIAP-associ ( 403) 237 42.8 0.0027 XP_011522247 (OMIM: 606717) PREDICTED: XIAP-associ ( 403) 237 42.8 0.0027 XP_016880269 (OMIM: 606717) PREDICTED: XIAP-associ ( 241) 227 41.3 0.0044 >>NP_001137378 (OMIM: 613197) TRAF-type zinc finger doma (582 aa) initn: 4042 init1: 4042 opt: 4042 Z-score: 2782.6 bits: 524.8 E(85289): 3e-148 Smith-Waterman score: 4042; 100.0% identity (100.0% similar) in 582 aa overlap (1-582:1-582) 10 20 30 40 50 60 pF1KE1 MAEFLDDQETRLCDNCKKEIPVFNFTIHEIHCQRNIGMCPTCKEPFPKSDMETHMAAEHC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAEFLDDQETRLCDNCKKEIPVFNFTIHEIHCQRNIGMCPTCKEPFPKSDMETHMAAEHC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 QVTCKCNKKLEKRLLKKHEETECPLRLAVCQHCDLELSILKLKEHEDYCGARTELCGNCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QVTCKCNKKLEKRLLKKHEETECPLRLAVCQHCDLELSILKLKEHEDYCGARTELCGNCG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 RNVLVKDLKTHPEVCGREGEEKRNEVAIPPNAYDESWGQDGIWIASQLLRQIEALDPPMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RNVLVKDLKTHPEVCGREGEEKRNEVAIPPNAYDESWGQDGIWIASQLLRQIEALDPPMR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 LPRRPLRAFESDVFHNRTTNQRNITAQVSIQNNLFEEQERQERNRGQQPPKEGGEESANL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPRRPLRAFESDVFHNRTTNQRNITAQVSIQNNLFEEQERQERNRGQQPPKEGGEESANL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 DFMLALSLQNEGQASSVAEQDFWRAVCEADQSHGGPRSLSDIKGAADEIMLPCEFCEELY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DFMLALSLQNEGQASSVAEQDFWRAVCEADQSHGGPRSLSDIKGAADEIMLPCEFCEELY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 PEELLIDHQTSCNPSRALPSLNTGSSSPRGVEEPDVIFQNFLQQAASNQLDSLMGLSNSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PEELLIDHQTSCNPSRALPSLNTGSSSPRGVEEPDVIFQNFLQQAASNQLDSLMGLSNSH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 PVEESIIIPCEFCGVQLEEEVLFHHQDQCDQRPATATNHVTEGIPRLDSQPQETSPELPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PVEESIIIPCEFCGVQLEEEVLFHHQDQCDQRPATATNHVTEGIPRLDSQPQETSPELPR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 RRVRHQGDLSSGYLDDTKQETANGPTSCLPPSRPINNMTATYNQLSRSTSGPRPGCQPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RRVRHQGDLSSGYLDDTKQETANGPTSCLPPSRPINNMTATYNQLSRSTSGPRPGCQPSS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE1 PCVPKLSNSDSQDIQGRNRDSQNGAIAPGHVSVIRPPQNLYPENIVPSFSPGPSGRYGAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PCVPKLSNSDSQDIQGRNRDSQNGAIAPGHVSVIRPPQNLYPENIVPSFSPGPSGRYGAS 490 500 510 520 530 540 550 560 570 580 pF1KE1 GRSEGGRNSRVTPAAANYRSRTAKAKPSKQQGAGDAEEEEEE :::::::::::::::::::::::::::::::::::::::::: NP_001 GRSEGGRNSRVTPAAANYRSRTAKAKPSKQQGAGDAEEEEEE 550 560 570 580 >>NP_006691 (OMIM: 613197) TRAF-type zinc finger domain- (582 aa) initn: 4042 init1: 4042 opt: 4042 Z-score: 2782.6 bits: 524.8 E(85289): 3e-148 Smith-Waterman score: 4042; 100.0% identity (100.0% similar) in 582 aa overlap (1-582:1-582) 10 20 30 40 50 60 pF1KE1 MAEFLDDQETRLCDNCKKEIPVFNFTIHEIHCQRNIGMCPTCKEPFPKSDMETHMAAEHC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MAEFLDDQETRLCDNCKKEIPVFNFTIHEIHCQRNIGMCPTCKEPFPKSDMETHMAAEHC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 QVTCKCNKKLEKRLLKKHEETECPLRLAVCQHCDLELSILKLKEHEDYCGARTELCGNCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 QVTCKCNKKLEKRLLKKHEETECPLRLAVCQHCDLELSILKLKEHEDYCGARTELCGNCG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 RNVLVKDLKTHPEVCGREGEEKRNEVAIPPNAYDESWGQDGIWIASQLLRQIEALDPPMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 RNVLVKDLKTHPEVCGREGEEKRNEVAIPPNAYDESWGQDGIWIASQLLRQIEALDPPMR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 LPRRPLRAFESDVFHNRTTNQRNITAQVSIQNNLFEEQERQERNRGQQPPKEGGEESANL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LPRRPLRAFESDVFHNRTTNQRNITAQVSIQNNLFEEQERQERNRGQQPPKEGGEESANL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 DFMLALSLQNEGQASSVAEQDFWRAVCEADQSHGGPRSLSDIKGAADEIMLPCEFCEELY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 DFMLALSLQNEGQASSVAEQDFWRAVCEADQSHGGPRSLSDIKGAADEIMLPCEFCEELY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 PEELLIDHQTSCNPSRALPSLNTGSSSPRGVEEPDVIFQNFLQQAASNQLDSLMGLSNSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 PEELLIDHQTSCNPSRALPSLNTGSSSPRGVEEPDVIFQNFLQQAASNQLDSLMGLSNSH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 PVEESIIIPCEFCGVQLEEEVLFHHQDQCDQRPATATNHVTEGIPRLDSQPQETSPELPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 PVEESIIIPCEFCGVQLEEEVLFHHQDQCDQRPATATNHVTEGIPRLDSQPQETSPELPR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 RRVRHQGDLSSGYLDDTKQETANGPTSCLPPSRPINNMTATYNQLSRSTSGPRPGCQPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 RRVRHQGDLSSGYLDDTKQETANGPTSCLPPSRPINNMTATYNQLSRSTSGPRPGCQPSS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE1 PCVPKLSNSDSQDIQGRNRDSQNGAIAPGHVSVIRPPQNLYPENIVPSFSPGPSGRYGAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 PCVPKLSNSDSQDIQGRNRDSQNGAIAPGHVSVIRPPQNLYPENIVPSFSPGPSGRYGAS 490 500 510 520 530 540 550 560 570 580 pF1KE1 GRSEGGRNSRVTPAAANYRSRTAKAKPSKQQGAGDAEEEEEE :::::::::::::::::::::::::::::::::::::::::: NP_006 GRSEGGRNSRVTPAAANYRSRTAKAKPSKQQGAGDAEEEEEE 550 560 570 580 >>NP_059993 (OMIM: 606717) XIAP-associated factor 1 isof (301 aa) initn: 446 init1: 197 opt: 423 Z-score: 309.2 bits: 66.2 E(85289): 1.8e-10 Smith-Waterman score: 423; 40.4% identity (66.7% similar) in 141 aa overlap (12-149:7-147) 10 20 30 40 50 60 pF1KE1 MAEFLDDQETRLCDNCKKEIPVFNFTIHEIHCQRNIGMCPTCKEPFPKSDMETHMAAEHC .: :::... :::.:: .: : . .:: :.:: :: :: : :: NP_059 MEGDFSVCRNCKRHVVSANFTLHEAYCLRFLVLCPECEEPVPKETMEEHCKLEHQ 10 20 30 40 50 70 80 90 100 110 pF1KE1 QVTCK-CNKKLEKRLLKKHEETECPLRLAVCQHCDLELSILKLKEHEDYCGARTELCGNC :: : :.....: :. :. .:: : . :. : :.... ::. ::.:::.::::: .: NP_059 QVGCTMCQQSMQKSSLEFHKANECQERPVECKFCKLDMQLSKLELHESYCGSRTELCQGC 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 GRNVLVKDLKTHPEVCGREGEE--KRNEVAIPPNAYDESWGQDGIWIASQLLRQIEALDP :. .. . : : .:: : . : .... : NP_059 GQFIMHRMLAQHRDVCRSEQAQLGKGERISAPEREIYCHYCNQMIPENKYFHHMGKCCPD 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 PMRLPRRPLRAFESDVFHNRTTNQRNITAQVSIQNNLFEEQERQERNRGQQPPKEGGEES NP_059 SEFKKHFPVGNPEILPSSLPSQAAENQTSTMEKDVRPKTRSINRFPLHSESSSKKAPRSK 180 190 200 210 220 230 >>XP_005256763 (OMIM: 606717) PREDICTED: XIAP-associated (256 aa) initn: 302 init1: 191 opt: 267 Z-score: 203.3 bits: 46.4 E(85289): 0.00014 Smith-Waterman score: 267; 38.2% identity (65.7% similar) in 102 aa overlap (51-149:1-102) 30 40 50 60 70 pF1KE1 PVFNFTIHEIHCQRNIGMCPTCKEPFPKSDMETHMAAEHCQVTCK-CNKKLEKRLLKKHE :: : :: :: : :.....: :. :. XP_005 MEEHCKLEHQQVGCTMCQQSMQKSSLEFHK 10 20 30 80 90 100 110 120 130 pF1KE1 ETECPLRLAVCQHCDLELSILKLKEHEDYCGARTELCGNCGRNVLVKDLKTHPEVCGREG .:: : . :. : :.... ::. ::.:::.::::: .::. .. . : : .:: : XP_005 ANECQERPVECKFCKLDMQLSKLELHESYCGSRTELCQGCGQFIMHRMLAQHRDVCRSEQ 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE1 EE--KRNEVAIPPNAYDESWGQDGIWIASQLLRQIEALDPPMRLPRRPLRAFESDVFHNR . : .... : XP_005 AQLGKGERISAPEREIYCHYCNQMIPENKYFHHMGKCCPDSEFKKHFPVGNPEILPSSLP 100 110 120 130 140 150 >>NP_954590 (OMIM: 606717) XIAP-associated factor 1 isof (282 aa) initn: 447 init1: 198 opt: 265 Z-score: 201.4 bits: 46.2 E(85289): 0.00018 Smith-Waterman score: 345; 36.4% identity (61.4% similar) in 140 aa overlap (12-149:7-128) 10 20 30 40 50 60 pF1KE1 MAEFLDDQETRLCDNCKKEIPVFNFTIHEIHCQRNIGMCPTCKEPFPKSDMETHMAAEHC .: :::... :::.:: .: : . .:: :.:: :: :: ::: NP_954 MEGDFSVCRNCKRHVVSANFTLHEAYCLRFLVLCPECEEPVPKETME-----EHC 10 20 30 40 50 70 80 90 100 110 120 pF1KE1 QVTCKCNKKLEKRLLKKHEETECPLRLAVCQHCDLELSILKLKEHEDYCGARTELCGNCG . :.... .:: : . :. : :.... ::. ::.:::.::::: .:: NP_954 K-------------LEHQQANECQERPVECKFCKLDMQLSKLELHESYCGSRTELCQGCG 60 70 80 90 130 140 150 160 170 pF1KE1 RNVLVKDLKTHPEVCGREGEE--KRNEVAIPPNAYDESWGQDGIWIASQLLRQIEALDPP . .. . : : .:: : . : .... : NP_954 QFIMHRMLAQHRDVCRSEQAQLGKGERISAPEREIYCHYCNQMIPENKYFHHMGKCCPDS 100 110 120 130 140 150 180 190 200 210 220 230 pF1KE1 MRLPRRPLRAFESDVFHNRTTNQRNITAQVSIQNNLFEEQERQERNRGQQPPKEGGEESA NP_954 EFKKHFPVGNPEILPSSLPSQAAENQTSTMEKDVRPKTRSINRFPLHSESSSKKAPRSKN 160 170 180 190 200 210 >>XP_011522249 (OMIM: 606717) PREDICTED: XIAP-associated (307 aa) initn: 263 init1: 191 opt: 237 Z-score: 181.8 bits: 42.7 E(85289): 0.0022 Smith-Waterman score: 237; 37.0% identity (67.4% similar) in 92 aa overlap (61-149:62-153) 40 50 60 70 80 pF1KE1 HCQRNIGMCPTCKEPFPKSDMETHMAAEHCQVTCK-CNKKLEKRLLKKHEETECPLRLAV :: : :.....: :. :. .:: : . XP_011 MGSGSHRVGPVLPAGEMGSESWGTRVQSSLQVGCTMCQQSMQKSSLEFHKANECQERPVE 40 50 60 70 80 90 90 100 110 120 130 140 pF1KE1 CQHCDLELSILKLKEHEDYCGARTELCGNCGRNVLVKDLKTHPEVCGREGEE--KRNEVA :. : :.... ::. ::.:::.::::: .::. .. . : : .:: : . : .... XP_011 CKFCKLDMQLSKLELHESYCGSRTELCQGCGQFIMHRMLAQHRDVCRSEQAQLGKGERIS 100 110 120 130 140 150 150 160 170 180 190 200 pF1KE1 IPPNAYDESWGQDGIWIASQLLRQIEALDPPMRLPRRPLRAFESDVFHNRTTNQRNITAQ : XP_011 APEREIYCHYCNQMIPENKYFHHMGKCCPDSEFKKHFPVGNPEILPSSLPSQAAENQTST 160 170 180 190 200 210 >>XP_011522250 (OMIM: 606717) PREDICTED: XIAP-associated (243 aa) initn: 216 init1: 191 opt: 235 Z-score: 181.7 bits: 42.3 E(85289): 0.0022 Smith-Waterman score: 235; 40.5% identity (69.6% similar) in 79 aa overlap (61-138:158-236) 40 50 60 70 80 pF1KE1 HCQRNIGMCPTCKEPFPKSDMETHMAAEHCQVTCK-CNKKLEKRLLKKHEETECPLRLAV :: : :.....: :. :. .:: : . XP_011 MGSGSHRVGPVLPAGEMGSESWGTRVQSSLQVGCTMCQQSMQKSSLEFHKANECQERPVE 130 140 150 160 170 180 90 100 110 120 130 140 pF1KE1 CQHCDLELSILKLKEHEDYCGARTELCGNCGRNVLVKDLKTHPEVCGREGEEKRNEVAIP :. : :.... ::. ::.:::.::::: .::. .. . : : .:: : XP_011 CKFCKLDMQLSKLELHESYCGSRTELCQGCGQFIMHRMLAQHRDVCRSEQAQLGKG 190 200 210 220 230 240 150 160 170 180 190 200 pF1KE1 PNAYDESWGQDGIWIASQLLRQIEALDPPMRLPRRPLRAFESDVFHNRTTNQRNITAQVS >>XP_011522248 (OMIM: 606717) PREDICTED: XIAP-associated (403 aa) initn: 246 init1: 191 opt: 237 Z-score: 180.2 bits: 42.8 E(85289): 0.0027 Smith-Waterman score: 237; 37.0% identity (67.4% similar) in 92 aa overlap (61-149:158-249) 40 50 60 70 80 pF1KE1 HCQRNIGMCPTCKEPFPKSDMETHMAAEHCQVTCK-CNKKLEKRLLKKHEETECPLRLAV :: : :.....: :. :. .:: : . XP_011 MGSGSHRVGPVLPAGEMGSESWGTRVQSSLQVGCTMCQQSMQKSSLEFHKANECQERPVE 130 140 150 160 170 180 90 100 110 120 130 140 pF1KE1 CQHCDLELSILKLKEHEDYCGARTELCGNCGRNVLVKDLKTHPEVCGREGEE--KRNEVA :. : :.... ::. ::.:::.::::: .::. .. . : : .:: : . : .... XP_011 CKFCKLDMQLSKLELHESYCGSRTELCQGCGQFIMHRMLAQHRDVCRSEQAQLGKGERIS 190 200 210 220 230 240 150 160 170 180 190 200 pF1KE1 IPPNAYDESWGQDGIWIASQLLRQIEALDPPMRLPRRPLRAFESDVFHNRTTNQRNITAQ : XP_011 APEREIYCHYCNQMIPENKYFHHMGKCCPDSEFKKHFPVGNPEILPSSLPSQAAENQTST 250 260 270 280 290 300 >>XP_011522247 (OMIM: 606717) PREDICTED: XIAP-associated (403 aa) initn: 263 init1: 191 opt: 237 Z-score: 180.2 bits: 42.8 E(85289): 0.0027 Smith-Waterman score: 237; 37.0% identity (67.4% similar) in 92 aa overlap (61-149:158-249) 40 50 60 70 80 pF1KE1 HCQRNIGMCPTCKEPFPKSDMETHMAAEHCQVTCK-CNKKLEKRLLKKHEETECPLRLAV :: : :.....: :. :. .:: : . XP_011 MGSGSHRVGPVLPAGEMGSESWGTRVQSSLQVGCTMCQQSMQKSSLEFHKANECQERPVE 130 140 150 160 170 180 90 100 110 120 130 140 pF1KE1 CQHCDLELSILKLKEHEDYCGARTELCGNCGRNVLVKDLKTHPEVCGREGEE--KRNEVA :. : :.... ::. ::.:::.::::: .::. .. . : : .:: : . : .... XP_011 CKFCKLDMQLSKLELHESYCGSRTELCQGCGQFIMHRMLAQHRDVCRSEQAQLGKGERIS 190 200 210 220 230 240 150 160 170 180 190 200 pF1KE1 IPPNAYDESWGQDGIWIASQLLRQIEALDPPMRLPRRPLRAFESDVFHNRTTNQRNITAQ : XP_011 APEREIYCHYCNQMIPENKYFHHMGKCCPDSEFKKHFPVGNPEILPSSLPSQAAENQTST 250 260 270 280 290 300 >>XP_016880269 (OMIM: 606717) PREDICTED: XIAP-associated (241 aa) initn: 263 init1: 191 opt: 227 Z-score: 176.3 bits: 41.3 E(85289): 0.0044 Smith-Waterman score: 227; 36.0% identity (68.6% similar) in 86 aa overlap (66-149:2-87) 40 50 60 70 80 90 pF1KE1 IGMCPTCKEPFPKSDMETHMAAEHCQVTCKCNKKLEKRLLKKHEETECPLRLAVCQHCDL :.....: :. :. .:: : . :. : : XP_016 MCQQSMQKSSLEFHKANECQERPVECKFCKL 10 20 30 100 110 120 130 140 150 pF1KE1 ELSILKLKEHEDYCGARTELCGNCGRNVLVKDLKTHPEVCGREGEE--KRNEVAIPPNAY .... ::. ::.:::.::::: .::. .. . : : .:: : . : .... : XP_016 DMQLSKLELHESYCGSRTELCQGCGQFIMHRMLAQHRDVCRSEQAQLGKGERISAPEREI 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE1 DESWGQDGIWIASQLLRQIEALDPPMRLPRRPLRAFESDVFHNRTTNQRNITAQVSIQNN XP_016 YCHYCNQMIPENKYFHHMGKCCPDSEFKKHFPVGNPEILPSSLPSQAAENQTSTMEKDVR 100 110 120 130 140 150 582 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 07:45:46 2016 done: Sat Nov 5 07:45:47 2016 Total Scan time: 12.360 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]