FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1048, 397 aa 1>>>pF1KE1048 397 - 397 aa - 397 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4489+/-0.000921; mu= 16.3802+/- 0.055 mean_var=67.4854+/-13.343, 0's: 0 Z-trim(105.4): 20 B-trim: 0 in 0/51 Lambda= 0.156124 statistics sampled from 8406 (8421) to 8406 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.64), E-opt: 0.2 (0.259), width: 16 Scan time: 2.870 The best scores are: opt bits E(32554) CCDS11939.1 ACAA2 gene_id:10449|Hs108|chr18 ( 397) 2580 590.1 1.2e-168 CCDS5268.1 ACAT2 gene_id:39|Hs108|chr6 ( 397) 1004 235.2 8.3e-62 CCDS8339.1 ACAT1 gene_id:38|Hs108|chr11 ( 427) 876 206.3 4.2e-53 CCDS2673.1 ACAA1 gene_id:30|Hs108|chr3 ( 424) 805 190.3 2.7e-48 CCDS46794.1 ACAA1 gene_id:30|Hs108|chr3 ( 331) 268 69.3 5.7e-12 >>CCDS11939.1 ACAA2 gene_id:10449|Hs108|chr18 (397 aa) initn: 2580 init1: 2580 opt: 2580 Z-score: 3141.5 bits: 590.1 E(32554): 1.2e-168 Smith-Waterman score: 2580; 100.0% identity (100.0% similar) in 397 aa overlap (1-397:1-397) 10 20 30 40 50 60 pF1KE1 MALLRGVFVVAAKRTPFGAYGGLLKDFTATDLSEFAAKAALSAGKVSPETVDSVIMGNVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 MALLRGVFVVAAKRTPFGAYGGLLKDFTATDLSEFAAKAALSAGKVSPETVDSVIMGNVL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 QSSSDAIYLARHVGLRVGIPKETPALTINRLCGSGFQSIVNGCQEICVKEAEVVLCGGTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 QSSSDAIYLARHVGLRVGIPKETPALTINRLCGSGFQSIVNGCQEICVKEAEVVLCGGTE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 SMSQAPYCVRNVRFGTKLGSDIKLEDSLWVSLTDQHVQLPMAMTAENLAVKHKISREECD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 SMSQAPYCVRNVRFGTKLGSDIKLEDSLWVSLTDQHVQLPMAMTAENLAVKHKISREECD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 KYALQSQQRWKAANDAGYFNDEMAPIEVKTKKGKQTMQVDEHARPQTTLEQLQKLPPVFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 KYALQSQQRWKAANDAGYFNDEMAPIEVKTKKGKQTMQVDEHARPQTTLEQLQKLPPVFK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 KDGTVTAGNASGVADGAGAVIIASEDAVKKHNFTPLARIVGYFVSGCDPSIMGIGPVPAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 KDGTVTAGNASGVADGAGAVIIASEDAVKKHNFTPLARIVGYFVSGCDPSIMGIGPVPAI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 SGALKKAGLSLKDMDLVEVNEAFAPQYLAVERSLDLDISKTNVNGGAIALGHPLGGSGSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 SGALKKAGLSLKDMDLVEVNEAFAPQYLAVERSLDLDISKTNVNGGAIALGHPLGGSGSR 310 320 330 340 350 360 370 380 390 pF1KE1 ITAHLVHELRRRGGKYAVGSACIGGGQGIAVIIQSTA ::::::::::::::::::::::::::::::::::::: CCDS11 ITAHLVHELRRRGGKYAVGSACIGGGQGIAVIIQSTA 370 380 390 >>CCDS5268.1 ACAT2 gene_id:39|Hs108|chr6 (397 aa) initn: 1026 init1: 534 opt: 1004 Z-score: 1223.1 bits: 235.2 E(32554): 8.3e-62 Smith-Waterman score: 1004; 43.0% identity (72.1% similar) in 391 aa overlap (7-394:8-395) 10 20 30 40 50 pF1KE1 MALLRGVFVVAAKRTPFGAYGGLLKDFTATDLSEFAAKAALSAGKVSPETVDSVIMGNV : .:.: :: .:...: : . ::. . : .:. . :.:: :. ::.:.: CCDS52 MNAGSDPVVIVSAARTIIGSFNGALAAVPVQDLGSTVIKEVLKRATVAPEDVSEVIFGHV 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 LQSSSDAIYLARHVGLRVGIPKETPALTINRLCGSGFQSIVNGCQEICVKEAEVVLCGGT : .. . :.... .::: .:: . . .::::.... . : : . .. .:. :: CCDS52 LAAGCGQNPV-RQASVGAGIPYSVPAWSCQMICGSGLKAVCLAVQSIGIGDSSIVVAGGM 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 ESMSQAPYCVRNVRFGTKLGSDIKLEDSLWVS-LTDQHVQLPMAMTAENLAVKHKISREE :.::.::. . .: :.:.: .. : ::. . ::: . :..::::.: : ..:::. CCDS52 ENMSKAPHLAY-LRTGVKIG-EMPLTDSILCDGLTDAFHNCHMGITAENVAKKWQVSRED 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 CDKYALQSQQRWKAANDAGYFNDEMAPIEVKTKKGKQTMQVDEHARPQTTLEQLQKLPPV :: :. ::.: . :. ::.:. :..:. :.:.:: ...:: : ...: ..:: : CCDS52 QDKVAVLSQNRTENAQKAGHFDKEIVPVLVSTRKGLIEVKTDEFPRHGSNIEAMSKLKPY 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE1 FKKDGT--VTAGNASGVADGAGAVIIASEDAVKKHNFTPLARIVGYFVSGCDPSIMGIGP : ::: :: .::::. :::.::.. ... . :...:::::::.. : .:::::::: CCDS52 FLTDGTGTVTPANASGINDGAAAVVLMKKSEADKRGLTPLARIVSWSQVGVEPSIMGIGP 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE1 VPAISGALKKAGLSLKDMDLVEVNEAFAPQYLAVERSLDLDISKTNVNGGAIALGHPLGG .:::. :. ::: ::.:.:. :.::::: :. . : :. :.:..:::::::::::. CCDS52 IPAIKQAVTKAGWSLEDVDIFEINEAFAAVSAAIVKELGLNPEKVNIEGGAIALGHPLGA 300 310 320 330 340 350 360 370 380 390 pF1KE1 SGSRITAHLVHELRRRGGKYAVGSACIGGGQGIAVIIQSTA :: :: . :.: :.: : . .:.. :::::.:::. .: CCDS52 SGCRILVTLLHTLERMGRSRGVAALCIGGGMGIAMCVQRE 360 370 380 390 >>CCDS8339.1 ACAT1 gene_id:38|Hs108|chr11 (427 aa) initn: 657 init1: 401 opt: 876 Z-score: 1066.8 bits: 206.3 E(32554): 4.2e-53 Smith-Waterman score: 876; 42.0% identity (70.6% similar) in 395 aa overlap (4-394:39-425) 10 20 30 pF1KE1 MALLRGVFVVAAKRTPFGAYGGLLKDFTATDLS :. : .:.: :::.:.. : :. . :: :. CCDS83 RSGARSRSPLLRRLVQEIRYVERSYVSKPTLKEVVIVSATRTPIGSFLGSLSLLPATKLG 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE1 EFAAKAALSAGKVSPETVDSVIMGNVLQSSSDAIYLARHVGLRVGIPKETPALTINRLCG .: ..:. . . : : . ::::::.. .. .:.. : .:.: :: :::..:. CCDS83 SIAIQGAIEKAGIPKEEVKEAYMGNVLQGG-EGQAPTRQAVLGAGLPISTPCTTINKVCA 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE1 SGFQSIVNGCQEICVKEAEVVLCGGTESMSQAPYCVRNVRFGTKLGSDIKLEDSLWVS-- ::...:. . : . . .:.. :: ::::..:: : : : .: :. .:::: : :. CCDS83 SGMKAIMMASQSLMCGHQDVMVAGGMESMSNVPY-VMN-RGSTPYGG-VKLED-LIVKDG 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE1 LTDQHVQLPMAMTAENLAVKHKISREECDKYALQSQQRWKAANDAGYFNDEMAPIEVKTK ::: . .. :. ::: : : .:.:.: : ::..: : ::: .:: :..:. :. : : CCDS83 LTDVYNKIHMGSCAENTAKKLNIARNEQDAYAINSYTRSKAAWEAGKFGNEVIPVTV-TV 190 200 210 220 230 240 220 230 240 250 260 pF1KE1 KGKQTMQVDEHAR-PQTTLEQLQKLPPVFKKD-GTVTAGNASGVADGAGAVIIASEDAVK ::. . : : . .. . .. :: ::.:. :::::.::: . :::.:... . ::.: CCDS83 KGQPDVVVKEDEEYKRVDFSKVPKLKTVFQKENGTVTAANASTLNDGAAALVLMTADAAK 250 260 270 280 290 300 270 280 290 300 310 320 pF1KE1 KHNFTPLARIVGYFVSGCDPSIMGIGPVPAISGALKKAGLSLKDMDLVEVNEAFAPQYLA . : :::::::.. .. .: . :.:: : : .:: .::. .:. . ::::::. :: CCDS83 RLNVTPLARIVAFADAAVEPIDFPIAPVYAASMVLKDVGLKKEDIAMWEVNEAFSLVVLA 310 320 330 340 350 360 330 340 350 360 370 380 pF1KE1 VERSLDLDISKTNVNGGAIALGHPLGGSGSRITAHLVHELRRRGGKYAVGSACIGGGQGI . :..: .:.:.::::..::::.: ::.::..::.: :.. :.:...: : ::: . CCDS83 NIKMLEIDPQKVNINGGAVSLGHPIGMSGARIVGHLTHALKQ--GEYGLASICNGGGGAS 370 380 390 400 410 420 390 pF1KE1 AVIIQSTA :..:: CCDS83 AMLIQKL >>CCDS2673.1 ACAA1 gene_id:30|Hs108|chr3 (424 aa) initn: 774 init1: 477 opt: 805 Z-score: 980.4 bits: 190.3 E(32554): 2.7e-48 Smith-Waterman score: 805; 39.2% identity (65.6% similar) in 395 aa overlap (7-394:38-420) 10 20 30 pF1KE1 MALLRGVFVVAAKRTPFGAYG-GLLKDFTATDLSEF : :: ..:: . : : .:: : .: CCDS26 LGHLRGPADSGWMPQAAPCLSGAPQASAADVVVVHGRRTAICRAGRGGFKDTTPDELLSA 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE1 AAKAALSAGKVSPETVDSVIMGNVLQSSSDAIYLARHVGLRVGIPKETPALTINRLCGSG . :.:. .. :: . .. .::::: .. :: .:: . . ::. .: :.:: :.:: CCDS26 VMTAVLKDVNLRPEQLGDICVGNVLQPGAGAI-MARIAQFLSDIPETVPLSTVNRQCSSG 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE1 FQSIVNGCQEICVKEAEVVLCGGTESMSQAPYCVRNVRFGTKLGSDIKLEDSLWVSLTDQ .:.... : .. . :.:::: : :. .. . : . . CCDS26 LQAVASIAGGIRNGSYDIGMACGVESMSLADR-----------GNPGNITSRLMEKEKAR 130 140 150 160 170 160 170 180 190 200 210 pF1KE1 HVQLPMAMTAENLAVKHKISREECDKYALQSQQRWKAANDAGYFNDEMAPIE--VKTKKG .::..:.::.: . ::::. : .:: :::. :.. : :. :..:. :. :: CCDS26 DCLIPMGITSENVAERFGISREKQDTFALASQQKAARAQSKGCFQAEIVPVTTTVHDDKG 180 190 200 210 220 230 220 230 240 250 260 270 pF1KE1 -KQTMQV--DEHARPQTTLEQLQKLPPVFKKDGTVTAGNASGVADGAGAVIIASEDAVKK :... : :: ::.::.: : :: :.:::::..::::.: :.:::.:...: .. ... CCDS26 TKRSITVTQDEGIRPSTTMEGLAKLKPAFKKDGSTTAGNSSQVSDGAAAILLARRSKAEE 240 250 260 270 280 290 280 290 300 310 320 330 pF1KE1 HNFTPLARIVGYFVSGCDPSIMGIGPVPAISGALKKAGLSLKDMDLVEVNEAFAPQYLAV .. :. . .: : : :.::::::. :: ::.::::...:.:. :.::::: : CCDS26 LGLPILGVLRSYAVVGVPPDIMGIGPAYAIPVALQKAGLTVSDVDIFEINEAFASQAAYC 300 310 320 330 340 350 340 350 360 370 380 pF1KE1 ERSLDLDISKTNVNGGAIALGHPLGGSGSRITAHLVHELRRRGGK-YAVGSACIGGGQGI ..: : :.: :::.::::::: .:.: . :..::.::: . :.: : ::: :.: CCDS26 VEKLRLPPEKVNPLGGAVALGHPLGCTGARQVITLLNELKRRGKRAYGVVSMCIGTGMGA 360 370 380 390 400 410 390 pF1KE1 AVIIQSTA :.... CCDS26 AAVFEYPGN 420 >>CCDS46794.1 ACAA1 gene_id:30|Hs108|chr3 (331 aa) initn: 581 init1: 214 opt: 268 Z-score: 328.4 bits: 69.3 E(32554): 5.7e-12 Smith-Waterman score: 445; 31.4% identity (51.1% similar) in 395 aa overlap (7-394:38-327) 10 20 30 pF1KE1 MALLRGVFVVAAKRTPFGAYG-GLLKDFTATDLSEF : :: ..:: . : : .:: : .: CCDS46 LGHLRGPADSGWMPQAAPCLSGAPQASAADVVVVHGRRTAICRAGRGGFKDTTPDELLSA 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE1 AAKAALSAGKVSPETVDSVIMGNVLQSSSDAIYLARHVGLRVGIPKETPALTINRLCGSG . :.:. .. :: . .. .::::: .. :: .:: . . ::. .: :.:: :.:: CCDS46 VMTAVLKDVNLRPEQLGDICVGNVLQPGAGAI-MARIAQFLSDIPETVPLSTVNRQCSSG 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE1 FQSIVNGCQEICVKEAEVVLCGGTESMSQAPYCVRNVRFGTKLGSDIKLEDSLWVSLTDQ .:.... . :: .:: :: CCDS46 LQAVAS-------------IAGG----------IRN-------GS--------------Y 130 140 160 170 180 190 200 210 pF1KE1 HVQLPMAMTAENLAVKHKISREECDKYALQSQQRWKAANDAGYFNDEMAPIE--VKTKKG . . ..:.::.: . ::::. : .:: :::. :.. : :. :..:. :. :: CCDS46 DIGMACGITSENVAERFGISREKQDTFALASQQKAARAQSKGCFQAEIVPVTTTVHDDKG 150 160 170 180 190 200 220 230 240 250 260 270 pF1KE1 -KQTMQV--DEHARPQTTLEQLQKLPPVFKKDGTVTAGNASGVADGAGAVIIASEDAVKK :... : :: ::.::.: : :: :.:::::..::: CCDS46 TKRSITVTQDEGIRPSTTMEGLAKLKPAFKKDGSTTAG---------------------- 210 220 230 240 280 290 300 310 320 330 pF1KE1 HNFTPLARIVGYFVSGCDPSIMGIGPVPAISGALKKAGLSLKDMDLVEVNEAFAPQYLAV :...:.:. :.::::: : CCDS46 --------------------------------------LTVSDVDIFEINEAFASQAAYC 250 260 340 350 360 370 380 pF1KE1 ERSLDLDISKTNVNGGAIALGHPLGGSGSRITAHLVHELRRRGGK-YAVGSACIGGGQGI ..: : :.: :::.::::::: .:.: . :..::.::: . :.: : ::: :.: CCDS46 VEKLRLPPEKVNPLGGAVALGHPLGCTGARQVITLLNELKRRGKRAYGVVSMCIGTGMGA 270 280 290 300 310 320 390 pF1KE1 AVIIQSTA :.... CCDS46 AAVFEYPGN 330 397 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 07:47:27 2016 done: Sat Nov 5 07:47:27 2016 Total Scan time: 2.870 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]