FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1051, 445 aa 1>>>pF1KE1051 445 - 445 aa - 445 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3350+/-0.00076; mu= 18.3246+/- 0.046 mean_var=72.5378+/-14.522, 0's: 0 Z-trim(109.4): 23 B-trim: 0 in 0/52 Lambda= 0.150589 statistics sampled from 10869 (10891) to 10869 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.696), E-opt: 0.2 (0.335), width: 16 Scan time: 3.160 The best scores are: opt bits E(32554) CCDS8013.1 FADS3 gene_id:3995|Hs108|chr11 ( 445) 3152 693.7 9.4e-200 CCDS8012.1 FADS2 gene_id:9415|Hs108|chr11 ( 444) 2051 454.5 9.5e-128 CCDS60808.1 FADS2 gene_id:9415|Hs108|chr11 ( 413) 1791 398.0 9e-111 CCDS60807.1 FADS2 gene_id:9415|Hs108|chr11 ( 422) 1791 398.0 9.2e-111 CCDS8011.2 FADS1 gene_id:3992|Hs108|chr11 ( 501) 1682 374.4 1.4e-103 >>CCDS8013.1 FADS3 gene_id:3995|Hs108|chr11 (445 aa) initn: 3152 init1: 3152 opt: 3152 Z-score: 3699.7 bits: 693.7 E(32554): 9.4e-200 Smith-Waterman score: 3152; 100.0% identity (100.0% similar) in 445 aa overlap (1-445:1-445) 10 20 30 40 50 60 pF1KE1 MGGVGEPGPREGPAQPGAPLPTFCWEQIRAHDQPGDKWLVIERRVYDISRWAQRHPGGSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS80 MGGVGEPGPREGPAQPGAPLPTFCWEQIRAHDQPGDKWLVIERRVYDISRWAQRHPGGSR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LIGHHGAEDATDAFRAFHQDLNFVRKFLQPLLIGELAPEEPSQDGPLNAQLVEDFRALHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS80 LIGHHGAEDATDAFRAFHQDLNFVRKFLQPLLIGELAPEEPSQDGPLNAQLVEDFRALHQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 AAEDMKLFDASPTFFAFLLGHILAMEVLAWLLIYLLGPGWVPSALAAFILAISQAQSWCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS80 AAEDMKLFDASPTFFAFLLGHILAMEVLAWLLIYLLGPGWVPSALAAFILAISQAQSWCL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 QHDLGHASIFKKSWWNHVAQKFVMGQLKGFSAHWWNFRHFQHHAKPNIFHKDPDVTVAPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS80 QHDLGHASIFKKSWWNHVAQKFVMGQLKGFSAHWWNFRHFQHHAKPNIFHKDPDVTVAPV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 FLLGESSVEYGKKKRRYLPYNQQHLYFFLIGPPLLTLVNFEVENLAYMLVCMQWADLLWA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS80 FLLGESSVEYGKKKRRYLPYNQQHLYFFLIGPPLLTLVNFEVENLAYMLVCMQWADLLWA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 ASFYARFFLSYLPFYGVPGVLLFFVAVRVLESHWFVWITQMNHIPKEIGHEKHRDWVSSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS80 ASFYARFFLSYLPFYGVPGVLLFFVAVRVLESHWFVWITQMNHIPKEIGHEKHRDWVSSQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 LAATCNVEPSLFTNWFSGHLNFQIEHHLFPRMPRHNYSRVAPLVKSLCAKHGLSYEVKPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS80 LAATCNVEPSLFTNWFSGHLNFQIEHHLFPRMPRHNYSRVAPLVKSLCAKHGLSYEVKPF 370 380 390 400 410 420 430 440 pF1KE1 LTALVDIVRSLKKSGDIWLDAYLHQ ::::::::::::::::::::::::: CCDS80 LTALVDIVRSLKKSGDIWLDAYLHQ 430 440 >>CCDS8012.1 FADS2 gene_id:9415|Hs108|chr11 (444 aa) initn: 2076 init1: 1064 opt: 2051 Z-score: 2407.0 bits: 454.5 E(32554): 9.5e-128 Smith-Waterman score: 2051; 62.6% identity (84.1% similar) in 446 aa overlap (1-445:1-444) 10 20 30 40 50 60 pF1KE1 MGGVGEPGPREGPAQPGAPLPTFCWEQIRAHDQPGDKWLVIERRVYDISRWAQRHPGGSR :: :. : :: :. . .::: ::.:. :. :.::::.:.::.:..:. .::::.: CCDS80 MGKGGNQG--EGAAEREVSVPTFSWEEIQKHNLRTDRWLVIDRKVYNITKWSIQHPGGQR 10 20 30 40 50 70 80 90 100 110 120 pF1KE1 LIGHHGAEDATDAFRAFHQDLNFVRKFLQPLLIGELAPEEPSQDGPLNAQLVEDFRALHQ .:::...::::::::::: ::.:: :::.::::::::::::::: :....::::::.. CCDS80 VIGHYAGEDATDAFRAFHPDLEFVGKFLKPLLIGELAPEEPSQDHGKNSKITEDFRALRK 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE1 AAEDMKLFDASPTFFAFLLGHILAMEVLAWLLIYLLGPGWVPSALAAFILAISQAQSWCL .::::.:: .. .:: .::.::.:.: .::. .. .: ::.:. ..::.:: ::::. : CCDS80 TAEDMNLFKTNHVFFLLLLAHIIALESIAWFTVFYFGNGWIPTLITAFVLATSQAQAGWL 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE1 QHDLGHASIFKKSWWNHVAQKFVMGQLKGFSAHWWNFRHFQHHAKPNIFHKDPDVTVAPV ::: :: :...: :::...:::.:.::: ::.::: ::::::::::::::::::.. : CCDS80 QHDYGHLSVYRKPKWNHLVHKFVIGHLKGASANWWNHRHFQHHAKPNIFHKDPDVNMLHV 180 190 200 210 220 230 250 260 270 280 290 pF1KE1 FLLGE-SSVEYGKKKRRYLPYNQQHLYFFLIGPPLLTLVNFEVENLAYMLVCMQWADLLW :.::: . .:::::: .:::::.:: :::::::::: . :. . . :.: .:.:: : CCDS80 FVLGEWQPIEYGKKKLKYLPYNHQHEYFFLIGPPLLIPMYFQYQIIMTMIVHKNWVDLAW 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE1 AASFYARFFLSYLPFYGVPGVLLFFVAVRVLESHWFVWITQMNHIPKEIGHEKHRDWVSS :.:.: :::..:.::::. :.:::. .: ::::::::.:::::: :: .: .::: :: CCDS80 AVSYYIRFFITYIPFYGILGALLFLNFIRFLESHWFVWVTQMNHIVMEIDQEAYRDWFSS 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE1 QLAATCNVEPSLFTNWFSGHLNFQIEHHLFPRMPRHNYSRVAPLVKSLCAKHGLSYEVKP ::.:::::: :.:..:::::::::::::::: ::::: ..::::::::::::. :. :: CCDS80 QLTATCNVEQSFFNDWFSGHLNFQIEHHLFPTMPRHNLHKIAPLVKSLCAKHGIEYQEKP 360 370 380 390 400 410 420 430 440 pF1KE1 FLTALVDIVRSLKKSGDIWLDAYLHQ .: ::.::.::::::: .:::::::. CCDS80 LLRALLDIIRSLKKSGKLWLDAYLHK 420 430 440 >>CCDS60808.1 FADS2 gene_id:9415|Hs108|chr11 (413 aa) initn: 1826 init1: 986 opt: 1791 Z-score: 2102.2 bits: 398.0 E(32554): 9e-111 Smith-Waterman score: 1791; 64.2% identity (84.7% similar) in 380 aa overlap (67-445:34-413) 40 50 60 70 80 90 pF1KE1 KWLVIERRVYDISRWAQRHPGGSRLIGHHGAEDATDAFRAFHQDLNFVRKFLQPLLIGEL : .. ::::::: ::.:: :::.::::::: CCDS60 EPPGCRRVNSLMLYTLRSITSHRSSHPERWATSSQDAFRAFHPDLEFVGKFLKPLLIGEL 10 20 30 40 50 60 100 110 120 130 140 150 pF1KE1 APEEPSQDGPLNAQLVEDFRALHQAAEDMKLFDASPTFFAFLLGHILAMEVLAWLLIYLL :::::::: :....::::::...::::.:: .. .:: .::.::.:.: .::. .. . CCDS60 APEEPSQDHGKNSKITEDFRALRKTAEDMNLFKTNHVFFLLLLAHIIALESIAWFTVFYF 70 80 90 100 110 120 160 170 180 190 200 210 pF1KE1 GPGWVPSALAAFILAISQAQSWCLQHDLGHASIFKKSWWNHVAQKFVMGQLKGFSAHWWN : ::.:. ..::.:: ::::. :::: :: :...: :::...:::.:.::: ::.::: CCDS60 GNGWIPTLITAFVLATSQAQAGWLQHDYGHLSVYRKPKWNHLVHKFVIGHLKGASANWWN 130 140 150 160 170 180 220 230 240 250 260 270 pF1KE1 FRHFQHHAKPNIFHKDPDVTVAPVFLLGE-SSVEYGKKKRRYLPYNQQHLYFFLIGPPLL ::::::::::::::::::.. ::.::: . .:::::: .:::::.:: :::::::::: CCDS60 HRHFQHHAKPNIFHKDPDVNMLHVFVLGEWQPIEYGKKKLKYLPYNHQHEYFFLIGPPLL 190 200 210 220 230 240 280 290 300 310 320 330 pF1KE1 TLVNFEVENLAYMLVCMQWADLLWAASFYARFFLSYLPFYGVPGVLLFFVAVRVLESHWF . :. . . :.: .:.:: ::.:.: :::..:.::::. :.:::. .: :::::: CCDS60 IPMYFQYQIIMTMIVHKNWVDLAWAVSYYIRFFITYIPFYGILGALLFLNFIRFLESHWF 250 260 270 280 290 300 340 350 360 370 380 390 pF1KE1 VWITQMNHIPKEIGHEKHRDWVSSQLAATCNVEPSLFTNWFSGHLNFQIEHHLFPRMPRH ::.:::::: :: .: .::: ::::.:::::: :.:..:::::::::::::::: :::: CCDS60 VWVTQMNHIVMEIDQEAYRDWFSSQLTATCNVEQSFFNDWFSGHLNFQIEHHLFPTMPRH 310 320 330 340 350 360 400 410 420 430 440 pF1KE1 NYSRVAPLVKSLCAKHGLSYEVKPFLTALVDIVRSLKKSGDIWLDAYLHQ : ..::::::::::::. :. ::.: ::.::.::::::: .:::::::. CCDS60 NLHKIAPLVKSLCAKHGIEYQEKPLLRALLDIIRSLKKSGKLWLDAYLHK 370 380 390 400 410 >>CCDS60807.1 FADS2 gene_id:9415|Hs108|chr11 (422 aa) initn: 1822 init1: 986 opt: 1791 Z-score: 2102.0 bits: 398.0 E(32554): 9.2e-111 Smith-Waterman score: 1791; 63.0% identity (83.2% similar) in 392 aa overlap (55-445:35-422) 30 40 50 60 70 80 pF1KE1 WEQIRAHDQPGDKWLVIERRVYDISRWAQRHPGGSRLIGHHGAEDATDAFRAFHQDLNFV ::... :: ::::::: ::.:: CCDS60 EAGPFVCVCVLLASIPTPQTPLLQASLPPFHPASA---GHP-ITGQQDAFRAFHPDLEFV 10 20 30 40 50 60 90 100 110 120 130 140 pF1KE1 RKFLQPLLIGELAPEEPSQDGPLNAQLVEDFRALHQAAEDMKLFDASPTFFAFLLGHILA :::.::::::::::::::: :....::::::...::::.:: .. .:: .::.::.: CCDS60 GKFLKPLLIGELAPEEPSQDHGKNSKITEDFRALRKTAEDMNLFKTNHVFFLLLLAHIIA 70 80 90 100 110 120 150 160 170 180 190 200 pF1KE1 MEVLAWLLIYLLGPGWVPSALAAFILAISQAQSWCLQHDLGHASIFKKSWWNHVAQKFVM .: .::. .. .: ::.:. ..::.:: ::::. :::: :: :...: :::...:::. CCDS60 LESIAWFTVFYFGNGWIPTLITAFVLATSQAQAGWLQHDYGHLSVYRKPKWNHLVHKFVI 130 140 150 160 170 180 210 220 230 240 250 260 pF1KE1 GQLKGFSAHWWNFRHFQHHAKPNIFHKDPDVTVAPVFLLGE-SSVEYGKKKRRYLPYNQQ :.::: ::.::: ::::::::::::::::::.. ::.::: . .:::::: .:::::.: CCDS60 GHLKGASANWWNHRHFQHHAKPNIFHKDPDVNMLHVFVLGEWQPIEYGKKKLKYLPYNHQ 190 200 210 220 230 240 270 280 290 300 310 320 pF1KE1 HLYFFLIGPPLLTLVNFEVENLAYMLVCMQWADLLWAASFYARFFLSYLPFYGVPGVLLF : :::::::::: . :. . . :.: .:.:: ::.:.: :::..:.::::. :.::: CCDS60 HEYFFLIGPPLLIPMYFQYQIIMTMIVHKNWVDLAWAVSYYIRFFITYIPFYGILGALLF 250 260 270 280 290 300 330 340 350 360 370 380 pF1KE1 FVAVRVLESHWFVWITQMNHIPKEIGHEKHRDWVSSQLAATCNVEPSLFTNWFSGHLNFQ . .: ::::::::.:::::: :: .: .::: ::::.:::::: :.:..::::::::: CCDS60 LNFIRFLESHWFVWVTQMNHIVMEIDQEAYRDWFSSQLTATCNVEQSFFNDWFSGHLNFQ 310 320 330 340 350 360 390 400 410 420 430 440 pF1KE1 IEHHLFPRMPRHNYSRVAPLVKSLCAKHGLSYEVKPFLTALVDIVRSLKKSGDIWLDAYL ::::::: ::::: ..::::::::::::. :. ::.: ::.::.::::::: .:::::: CCDS60 IEHHLFPTMPRHNLHKIAPLVKSLCAKHGIEYQEKPLLRALLDIIRSLKKSGKLWLDAYL 370 380 390 400 410 420 pF1KE1 HQ :. CCDS60 HK >>CCDS8011.2 FADS1 gene_id:3992|Hs108|chr11 (501 aa) initn: 1719 init1: 922 opt: 1682 Z-score: 1973.0 bits: 374.4 E(32554): 1.4e-103 Smith-Waterman score: 1682; 52.4% identity (78.2% similar) in 450 aa overlap (3-445:52-501) 10 20 pF1KE1 MGGVGEPGPREGP--AQPGAPLPT---FCWEQ ::..:. : :. .: :: : :.. CCDS80 RLALGARQQIHSWSPRTPSTRLTAPAGPARGVARPAMAPDPVAAETAAQGPTPRYFTWDE 30 40 50 60 70 80 30 40 50 60 70 80 pF1KE1 IRAHDQPGDKWLVIERRVYDISRWAQRHPGGSRLIGHHGAEDATDAFRAFHQDLNFVRKF . .. ..::::.:.::.::....:::::::.:.:....:::: : ::: . ..:.:. CCDS80 VAQRSGCEERWLVIDRKVYNISEFTRRHPGGSRVISHYAGQDATDPFVAFHINKGLVKKY 90 100 110 120 130 140 90 100 110 120 130 140 pF1KE1 LQPLLIGELAPEEPSQDGPLNAQLVEDFRALHQAAEDMKLFDASPTFFAFLLGHILAMEV .. ::::::.::.:: . : .:...:: :. ..: : :. :. .:: . : ::: .. CCDS80 MNSLLIGELSPEQPSFEPTKNKELTDEFRELRATVERMGLMKANHVFFLLYLLHILLLDG 150 160 170 180 190 200 150 160 170 180 190 200 pF1KE1 LAWLLIYLLGPGWVPSALAAFILAISQAQSWCLQHDLGHASIFKKSWWNHVAQKFVMGQL ::: ....: ...: : : .:. :::. ::::.:: :.:. : :::. ..::.:.: CCDS80 AAWLTLWVFGTSFLPFLLCAVLLSAVQAQAGWLQHDFGHLSVFSTSKWNHLLHHFVIGHL 210 220 230 240 250 260 210 220 230 240 250 260 pF1KE1 KGFSAHWWNFRHFQHHAKPNIFHKDPDVTVAPVFL-LGES-SVEYGKKKRRYLPYNQQHL :: : ::: ::::::::: :.::::... : :. ::. ::: ::.:..:.:::.:: CCDS80 KGAPASWWNHMHFQHHAKPNCFRKDPDINMHPFFFALGKILSVELGKQKKKYMPYNHQHK 270 280 290 300 310 320 270 280 290 300 310 320 pF1KE1 YFFLIGPPLLTLVNFEVENLAYMLVCMQWADLLWAASFYARFFLSYLPFYGVPGVLLFFV :::::::: : . :. . ... .:.:: : .::.::::.:.:. :. . : .: CCDS80 YFFLIGPPALLPLYFQWYIFYFVIQRKKWVDLAWMITFYVRFFLTYVPLLGLKAFLGLFF 330 340 350 360 370 380 330 340 350 360 370 380 pF1KE1 AVRVLESHWFVWITQMNHIPKEIGHEKHRDWVSSQLAATCNVEPSLFTNWFSGHLNFQIE :: :::.::::.::::::: .: :... ::::.:: :::::. : :..::::::::::: CCDS80 IVRFLESNWFVWVTQMNHIPMHIDHDRNMDWVSTQLQATCNVHKSAFNDWFSGHLNFQIE 390 400 410 420 430 440 390 400 410 420 430 440 pF1KE1 HHLFPRMPRHNYSRVAPLVKSLCAKHGLSYEVKPFLTALVDIVRSLKKSGDIWLDAYLHQ ::::: :::::: .:::::.:::::::. :. ::.:.:..::..:::.::..:::::::: CCDS80 HHLFPTMPRHNYHKVAPLVQSLCAKHGIEYQSKPLLSAFADIIHSLKESGQLWLDAYLHQ 450 460 470 480 490 500 445 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 07:49:17 2016 done: Sat Nov 5 07:49:17 2016 Total Scan time: 3.160 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]