FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1064, 100 aa 1>>>pF1KE1064 100 - 100 aa - 100 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0313+/-0.0003; mu= 11.4498+/- 0.019 mean_var=67.1871+/-13.222, 0's: 0 Z-trim(116.7): 27 B-trim: 55 in 1/55 Lambda= 0.156470 statistics sampled from 28128 (28155) to 28128 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.715), E-opt: 0.2 (0.33), width: 16 Scan time: 3.940 The best scores are: opt bits E(85289) NP_004772 (OMIM: 603657) vesicle-associated membra ( 100) 646 153.7 4.5e-38 XP_016858330 (OMIM: 603657) PREDICTED: vesicle-ass ( 122) 606 144.8 2.7e-35 NP_055046 (OMIM: 108600,185880) vesicle-associated ( 118) 463 112.5 1.4e-25 NP_055047 (OMIM: 185881) vesicle-associated membra ( 116) 461 112.0 1.9e-25 NP_001317054 (OMIM: 185881) vesicle-associated mem ( 118) 461 112.0 1.9e-25 NP_058439 (OMIM: 108600,185880) vesicle-associated ( 116) 457 111.1 3.5e-25 NP_001284367 (OMIM: 108600,185880) vesicle-associa ( 116) 457 111.1 3.5e-25 NP_954740 (OMIM: 108600,185880) vesicle-associated ( 117) 457 111.1 3.5e-25 NP_001172056 (OMIM: 606909) vesicle-associated mem ( 140) 280 71.2 4.4e-13 NP_003753 (OMIM: 606909) vesicle-associated membra ( 141) 280 71.2 4.4e-13 NP_003752 (OMIM: 603177) vesicle-associated membra ( 100) 222 58.0 2.9e-09 NP_006625 (OMIM: 607029) vesicle-associated membra ( 116) 192 51.3 3.6e-07 XP_016885552 (OMIM: 300053) PREDICTED: vesicle-ass ( 173) 166 45.5 2.9e-05 XP_016885249 (OMIM: 300053) PREDICTED: vesicle-ass ( 173) 166 45.5 2.9e-05 NP_001138621 (OMIM: 300053) vesicle-associated mem ( 179) 166 45.6 3e-05 NP_005629 (OMIM: 300053) vesicle-associated membra ( 220) 166 45.6 3.5e-05 >>NP_004772 (OMIM: 603657) vesicle-associated membrane p (100 aa) initn: 646 init1: 646 opt: 646 Z-score: 804.5 bits: 153.7 E(85289): 4.5e-38 Smith-Waterman score: 646; 100.0% identity (100.0% similar) in 100 aa overlap (1-100:1-100) 10 20 30 40 50 60 pF1KE1 MSTGPTAATGSNRRLQQTQNQVDEVVDIMRVNVDKVLERDQKLSELDDRADALQAGASQF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MSTGPTAATGSNRRLQQTQNQVDEVVDIMRVNVDKVLERDQKLSELDDRADALQAGASQF 10 20 30 40 50 60 70 80 90 100 pF1KE1 ETSAAKLKRKYWWKNCKMWAIGITVLVIFIIIIIVWVVSS :::::::::::::::::::::::::::::::::::::::: NP_004 ETSAAKLKRKYWWKNCKMWAIGITVLVIFIIIIIVWVVSS 70 80 90 100 >>XP_016858330 (OMIM: 603657) PREDICTED: vesicle-associa (122 aa) initn: 606 init1: 606 opt: 606 Z-score: 754.5 bits: 144.8 E(85289): 2.7e-35 Smith-Waterman score: 606; 100.0% identity (100.0% similar) in 94 aa overlap (1-94:1-94) 10 20 30 40 50 60 pF1KE1 MSTGPTAATGSNRRLQQTQNQVDEVVDIMRVNVDKVLERDQKLSELDDRADALQAGASQF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSTGPTAATGSNRRLQQTQNQVDEVVDIMRVNVDKVLERDQKLSELDDRADALQAGASQF 10 20 30 40 50 60 70 80 90 100 pF1KE1 ETSAAKLKRKYWWKNCKMWAIGITVLVIFIIIIIVWVVSS :::::::::::::::::::::::::::::::::: XP_016 ETSAAKLKRKYWWKNCKMWAIGITVLVIFIIIIIGELPFSKLIGKVFSMCSQTIDFVYKN 70 80 90 100 110 120 XP_016 SD >>NP_055046 (OMIM: 108600,185880) vesicle-associated mem (118 aa) initn: 454 init1: 437 opt: 463 Z-score: 580.2 bits: 112.5 E(85289): 1.4e-25 Smith-Waterman score: 463; 73.1% identity (88.2% similar) in 93 aa overlap (4-96:23-115) 10 20 30 40 pF1KE1 MSTGPTAATGSNRRLQQTQNQVDEVVDIMRVNVDKVLERDQ :: ::::::::: ::.:::::.:::::::::::: NP_055 MSAPAQPPAEGTEGTAPGGGPPGPPPNMTSNRRLQQTQAQVEEVVDIIRVNVDKVLERDQ 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE1 KLSELDDRADALQAGASQFETSAAKLKRKYWWKNCKMWAIGITVLVIFIIIIIVWVVSS ::::::::::::::::::::.:::::::::::::::: . .. .:....:... NP_055 KLSELDDRADALQAGASQFESSAAKLKRKYWWKNCKMMIMLGAICAIIVVVIVIYFFT 70 80 90 100 110 >>NP_055047 (OMIM: 185881) vesicle-associated membrane p (116 aa) initn: 500 init1: 455 opt: 461 Z-score: 577.9 bits: 112.0 E(85289): 1.9e-25 Smith-Waterman score: 461; 81.3% identity (85.7% similar) in 91 aa overlap (5-94:22-112) 10 20 30 40 pF1KE1 MSTGPTAATGSNRRLQQTQNQVDEVVDIMRVNVDKVLERDQKL : ::::::::: ::::::::::::::::::::::: NP_055 MSATAATAPPAAPAGEGGPPAPPPNLTSNRRLQQTQAQVDEVVDIMRVNVDKVLERDQKL 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE1 SELDDRADALQAGASQFETSAAKLKRKYWWKNCKMWAI-GITVLVIFIIIIIVWVVSS :::::::::::::::::::::::::::::::: :: : :. .:.::::. NP_055 SELDDRADALQAGASQFETSAAKLKRKYWWKNLKMMIILGVICAIILIIIIVYFST 70 80 90 100 110 >>NP_001317054 (OMIM: 185881) vesicle-associated membran (118 aa) initn: 511 init1: 455 opt: 461 Z-score: 577.8 bits: 112.0 E(85289): 1.9e-25 Smith-Waterman score: 461; 81.3% identity (85.7% similar) in 91 aa overlap (5-94:24-114) 10 20 30 40 pF1KE1 MSTGPTAATGSNRRLQQTQNQVDEVVDIMRVNVDKVLERDQ : ::::::::: ::::::::::::::::::::: NP_001 MDRSATAATAPPAAPAGEGGPPAPPPNLTSNRRLQQTQAQVDEVVDIMRVNVDKVLERDQ 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE1 KLSELDDRADALQAGASQFETSAAKLKRKYWWKNCKMWAI-GITVLVIFIIIIIVWVVSS :::::::::::::::::::::::::::::::::: :: : :. .:.::::. NP_001 KLSELDDRADALQAGASQFETSAAKLKRKYWWKNLKMMIILGVICAIILIIIIVYFST 70 80 90 100 110 >>NP_058439 (OMIM: 108600,185880) vesicle-associated mem (116 aa) initn: 437 init1: 437 opt: 457 Z-score: 573.0 bits: 111.1 E(85289): 3.5e-25 Smith-Waterman score: 457; 74.7% identity (87.9% similar) in 91 aa overlap (4-94:23-113) 10 20 30 40 pF1KE1 MSTGPTAATGSNRRLQQTQNQVDEVVDIMRVNVDKVLERDQ :: ::::::::: ::.:::::.:::::::::::: NP_058 MSAPAQPPAEGTEGTAPGGGPPGPPPNMTSNRRLQQTQAQVEEVVDIIRVNVDKVLERDQ 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE1 KLSELDDRADALQAGASQFETSAAKLKRKYWWKNCKMWAIGITVLVIFIIIIIVWVVSS ::::::::::::::::::::.:::::::::::::::: . .. .:....:. NP_058 KLSELDDRADALQAGASQFESSAAKLKRKYWWKNCKMMIMLGAICAIIVVVIVRRD 70 80 90 100 110 >>NP_001284367 (OMIM: 108600,185880) vesicle-associated (116 aa) initn: 437 init1: 437 opt: 457 Z-score: 573.0 bits: 111.1 E(85289): 3.5e-25 Smith-Waterman score: 457; 74.7% identity (87.9% similar) in 91 aa overlap (4-94:23-113) 10 20 30 40 pF1KE1 MSTGPTAATGSNRRLQQTQNQVDEVVDIMRVNVDKVLERDQ :: ::::::::: ::.:::::.:::::::::::: NP_001 MSAPAQPPAEGTEGTAPGGGPPGPPPNMTSNRRLQQTQAQVEEVVDIIRVNVDKVLERDQ 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE1 KLSELDDRADALQAGASQFETSAAKLKRKYWWKNCKMWAIGITVLVIFIIIIIVWVVSS ::::::::::::::::::::.:::::::::::::::: . .. .:....:. NP_001 KLSELDDRADALQAGASQFESSAAKLKRKYWWKNCKMMIMLGAICAIIVVVIVRRG 70 80 90 100 110 >>NP_954740 (OMIM: 108600,185880) vesicle-associated mem (117 aa) initn: 453 init1: 437 opt: 457 Z-score: 573.0 bits: 111.1 E(85289): 3.5e-25 Smith-Waterman score: 457; 74.7% identity (87.9% similar) in 91 aa overlap (4-94:23-113) 10 20 30 40 pF1KE1 MSTGPTAATGSNRRLQQTQNQVDEVVDIMRVNVDKVLERDQ :: ::::::::: ::.:::::.:::::::::::: NP_954 MSAPAQPPAEGTEGTAPGGGPPGPPPNMTSNRRLQQTQAQVEEVVDIIRVNVDKVLERDQ 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE1 KLSELDDRADALQAGASQFETSAAKLKRKYWWKNCKMWAIGITVLVIFIIIIIVWVVSS ::::::::::::::::::::.:::::::::::::::: . .. .:....:. NP_954 KLSELDDRADALQAGASQFESSAAKLKRKYWWKNCKMMIMLGAICAIIVVVIVSKYR 70 80 90 100 110 >>NP_001172056 (OMIM: 606909) vesicle-associated membran (140 aa) initn: 296 init1: 265 opt: 280 Z-score: 355.9 bits: 71.2 E(85289): 4.4e-13 Smith-Waterman score: 280; 38.5% identity (79.2% similar) in 96 aa overlap (3-98:41-135) 10 20 30 pF1KE1 MSTGPTAATGSNRRLQQTQNQVDEVVDIMRVN .:: . : .....:::::::.:.:. : NP_001 DDDVTGSVKSERRNLLEDDSDEEEDFFLGPSGPRFGP-RNDKIKHVQNQVDEVIDVMQEN 20 30 40 50 60 40 50 60 70 80 90 pF1KE1 VDKVLERDQKLSELDDRADALQAGASQFETSAAKLKRKYWWKNCKMWAIGITVLVIFIII . ::.:: ..:.::.:....:. .:. : . . .:.:..::..::. :: : .:.... NP_001 ITKVIERGERLDELQDKSESLSDNATAFSNRSKQLRRQMWWRGCKIKAIMALVAAILLLV 70 80 90 100 110 120 100 pF1KE1 IIVWVVSS ::. .: NP_001 IIILIVMKYRT 130 140 >>NP_003753 (OMIM: 606909) vesicle-associated membrane p (141 aa) initn: 296 init1: 265 opt: 280 Z-score: 355.9 bits: 71.2 E(85289): 4.4e-13 Smith-Waterman score: 280; 38.5% identity (79.2% similar) in 96 aa overlap (3-98:42-136) 10 20 30 pF1KE1 MSTGPTAATGSNRRLQQTQNQVDEVVDIMRVN .:: . : .....:::::::.:.:. : NP_003 DDVTGSVKSERRNLLEDDSDEEEDFFLRGPSGPRFGP-RNDKIKHVQNQVDEVIDVMQEN 20 30 40 50 60 70 40 50 60 70 80 90 pF1KE1 VDKVLERDQKLSELDDRADALQAGASQFETSAAKLKRKYWWKNCKMWAIGITVLVIFIII . ::.:: ..:.::.:....:. .:. : . . .:.:..::..::. :: : .:.... NP_003 ITKVIERGERLDELQDKSESLSDNATAFSNRSKQLRRQMWWRGCKIKAIMALVAAILLLV 80 90 100 110 120 130 100 pF1KE1 IIVWVVSS ::. .: NP_003 IIILIVMKYRT 140 100 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 02:42:18 2016 done: Sat Nov 5 02:42:19 2016 Total Scan time: 3.940 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]