FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1095, 360 aa 1>>>pF1KE1095 360 - 360 aa - 360 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.5332+/-0.000404; mu= 15.3726+/- 0.025 mean_var=81.7771+/-17.242, 0's: 0 Z-trim(112.4): 79 B-trim: 831 in 1/54 Lambda= 0.141827 statistics sampled from 21171 (21250) to 21171 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.625), E-opt: 0.2 (0.249), width: 16 Scan time: 8.090 The best scores are: opt bits E(85289) NP_001025067 (OMIM: 300526,300894) WD repeat domai ( 360) 2429 507.0 2.6e-143 NP_009006 (OMIM: 300526,300894) WD repeat domain p ( 361) 2417 504.6 1.4e-142 XP_005256434 (OMIM: 609226) PREDICTED: WD repeat d ( 310) 858 185.5 1.4e-46 NP_062559 (OMIM: 609226) WD repeat domain phosphoi ( 344) 858 185.6 1.5e-46 XP_016880351 (OMIM: 609226) PREDICTED: WD repeat d ( 226) 767 166.8 4.2e-41 XP_016880352 (OMIM: 609226) PREDICTED: WD repeat d ( 226) 767 166.8 4.2e-41 NP_001307701 (OMIM: 609224) WD repeat domain phosp ( 364) 356 82.9 1.3e-15 NP_060453 (OMIM: 609224) WD repeat domain phosphoi ( 446) 356 82.9 1.5e-15 NP_001028692 (OMIM: 609225) WD repeat domain phosp ( 384) 319 75.3 2.5e-13 NP_001028691 (OMIM: 609225) WD repeat domain phosp ( 425) 319 75.3 2.7e-13 NP_057087 (OMIM: 609225) WD repeat domain phosphoi ( 436) 319 75.3 2.8e-13 NP_001028690 (OMIM: 609225) WD repeat domain phosp ( 443) 319 75.3 2.8e-13 NP_056425 (OMIM: 609225) WD repeat domain phosphoi ( 454) 319 75.4 2.9e-13 XP_016880297 (OMIM: 609224) PREDICTED: WD repeat d ( 318) 293 69.9 8.7e-12 XP_016867441 (OMIM: 609225) PREDICTED: WD repeat d ( 299) 268 64.8 2.9e-10 XP_006715748 (OMIM: 609225) PREDICTED: WD repeat d ( 310) 268 64.8 3e-10 NP_001265228 (OMIM: 609225) WD repeat domain phosp ( 310) 268 64.8 3e-10 >>NP_001025067 (OMIM: 300526,300894) WD repeat domain ph (360 aa) initn: 2429 init1: 2429 opt: 2429 Z-score: 2693.9 bits: 507.0 E(85289): 2.6e-143 Smith-Waterman score: 2429; 100.0% identity (100.0% similar) in 360 aa overlap (1-360:1-360) 10 20 30 40 50 60 pF1KE1 MTQQPLRGVTSLRFNQDQSCFCCAMETGVRIYNVEPLMEKGHLDHEQVGSMGLVEMLHRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTQQPLRGVTSLRFNQDQSCFCCAMETGVRIYNVEPLMEKGHLDHEQVGSMGLVEMLHRS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 NLLALVGGGSSPKFSEISVLIWDDAREGKDSKEKLVLEFTFTKPVLSVRMRHDKIVIVLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NLLALVGGGSSPKFSEISVLIWDDAREGKDSKEKLVLEFTFTKPVLSVRMRHDKIVIVLK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 NRIYVYSFPDNPRKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGHKCGSLQLVDLASTKPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NRIYVYSFPDNPRKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGHKCGSLQLVDLASTKPG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 TSSAPFTINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPATL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TSSAPFTINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPATL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 YCINFSHDSSFLCASSDKGTVHIFALKDTRLNRRSALARVGKVGPMIGQYVDSQWSLASF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YCINFSHDSSFLCASSDKGTVHIFALKDTRLNRRSALARVGKVGPMIGQYVDSQWSLASF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 TVPAESACICAFGRNTSKNVNSVIAICVDGTFHKYVFTPDGNCNREAFDVYLDICDDDDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TVPAESACICAFGRNTSKNVNSVIAICVDGTFHKYVFTPDGNCNREAFDVYLDICDDDDF 310 320 330 340 350 360 >>NP_009006 (OMIM: 300526,300894) WD repeat domain phosp (361 aa) initn: 1906 init1: 1906 opt: 2417 Z-score: 2680.6 bits: 504.6 E(85289): 1.4e-142 Smith-Waterman score: 2417; 99.7% identity (99.7% similar) in 361 aa overlap (1-360:1-361) 10 20 30 40 50 60 pF1KE1 MTQQPLRGVTSLRFNQDQSCFCCAMETGVRIYNVEPLMEKGHLDHEQVGSMGLVEMLHRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 MTQQPLRGVTSLRFNQDQSCFCCAMETGVRIYNVEPLMEKGHLDHEQVGSMGLVEMLHRS 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 NLLALVGGGSSPKFSEIS-VLIWDDAREGKDSKEKLVLEFTFTKPVLSVRMRHDKIVIVL :::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::: NP_009 NLLALVGGGSSPKFSEISAVLIWDDAREGKDSKEKLVLEFTFTKPVLSVRMRHDKIVIVL 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE1 KNRIYVYSFPDNPRKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGHKCGSLQLVDLASTKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 KNRIYVYSFPDNPRKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGHKCGSLQLVDLASTKP 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE1 GTSSAPFTINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 GTSSAPFTINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPAT 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE1 LYCINFSHDSSFLCASSDKGTVHIFALKDTRLNRRSALARVGKVGPMIGQYVDSQWSLAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 LYCINFSHDSSFLCASSDKGTVHIFALKDTRLNRRSALARVGKVGPMIGQYVDSQWSLAS 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE1 FTVPAESACICAFGRNTSKNVNSVIAICVDGTFHKYVFTPDGNCNREAFDVYLDICDDDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 FTVPAESACICAFGRNTSKNVNSVIAICVDGTFHKYVFTPDGNCNREAFDVYLDICDDDD 310 320 330 340 350 360 360 pF1KE1 F : NP_009 F >>XP_005256434 (OMIM: 609226) PREDICTED: WD repeat domai (310 aa) initn: 739 init1: 359 opt: 858 Z-score: 957.5 bits: 185.5 E(85289): 1.4e-46 Smith-Waterman score: 934; 43.3% identity (68.7% similar) in 351 aa overlap (8-357:12-308) 10 20 30 40 50 pF1KE1 MTQQPLRGVTSLRFNQDQSCFCCAMETGVRIYNVEPLMEKGHLDHEQVGSMGLVEM :. ::::..:: :.::.: :.::..:: :: XP_005 MNLLPCNPHGNGLLYAGFNQDHGCFACGMENGFRVYNTDPLKEK---------------- 10 20 30 40 60 70 80 90 100 110 pF1KE1 LHRSNLLALVGGGSSPKFSEISVLIWDDAREGKDSKEKLVLEFTFTKPVLSVRMRHDKIV : .:.:::: :.: :.:. :. : .:..:.:.:: XP_005 -------------------EKQVMIWDDL------KKKTVIEIEFSTEVKAVKLRRDRIV 50 60 70 120 130 140 150 160 170 pF1KE1 IVLKNRIYVYSFPDNPRKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGHKCGSLQLVDLAS .:: . : :..: ::..: :.: :::::: :::. ...::.::: . : .::::::: XP_005 VVLDSMIKVFTFTHNPHQLHVFETCYNPKGLCVLCPNSNNSLLAFPGTHTGHVQLVDLAS 80 90 100 110 120 130 180 190 200 210 220 230 pF1KE1 T-KPGTSSAPFTINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGT : :: : : ::.. ..:..:: :: .:.::.::::::.:::.: . . :::::. XP_005 TEKP-----PVDIPAHEGVLSCIALNLQGTRIATASEKGTLIRIFDTSSGHLIQELRRGS 140 150 160 170 180 190 240 250 260 270 280 290 pF1KE1 DPATLYCINFSHDSSFLCASSDKGTVHIFALKDTRLNRRSALARVGKVGPMIGQYVDSQW . :..:::::..:.:..:.:::.::::::: .: . :..:.:: .. .. .: .:.: XP_005 QAANIYCINFNQDASLICVSSDHGTVHIFAAEDPKRNKQSSLASAS----FLPKYFSSKW 200 210 220 230 240 250 300 310 320 330 340 350 pF1KE1 SLASFTVPAESACICAFGRNTSKNVNSVIAICVDGTFHKYVFTPDGNCNREAFDVYLDIC :...: ::. : :::::: . :.:::::.::...:..:.: :.: :... .:.. XP_005 SFSKFQVPSGSPCICAFGTEP----NAVIAICADGSYYKFLFNPKGECIRDVYAQFLEMT 260 270 280 290 300 360 pF1KE1 DDDDF :: XP_005 DDKL 310 >>NP_062559 (OMIM: 609226) WD repeat domain phosphoinosi (344 aa) initn: 731 init1: 359 opt: 858 Z-score: 956.9 bits: 185.6 E(85289): 1.5e-46 Smith-Waterman score: 1101; 47.9% identity (75.5% similar) in 351 aa overlap (8-357:12-342) 10 20 30 40 50 pF1KE1 MTQQPLRGVTSLRFNQDQSCFCCAMETGVRIYNVEPLMEKGHLDHEQVGSMGLVEM :. ::::..:: :.::.: :.::..:: :: . . . :..: ::: NP_062 MNLLPCNPHGNGLLYAGFNQDHGCFACGMENGFRVYNTDPLKEKEKQEFLE-GGVGHVEM 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 LHRSNLLALVGGGSSPKFSEISVLIWDDAREGKDSKEKLVLEFTFTKPVLSVRMRHDKIV : : : :::::::..::. .:.:::: :.: :.:. :. : .:..:.:.:: NP_062 LFRCNYLALVGGGKKPKYPPNKVMIWDDL------KKKTVIEIEFSTEVKAVKLRRDRIV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 IVLKNRIYVYSFPDNPRKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGHKCGSLQLVDLAS .:: . : :..: ::..: :.: :::::: :::. ...::.::: . : .::::::: NP_062 VVLDSMIKVFTFTHNPHQLHVFETCYNPKGLCVLCPNSNNSLLAFPGTHTGHVQLVDLAS 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 T-KPGTSSAPFTINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGT : :: : : ::.. ..:..:: :: .:.::.::::::.:::.: . . :::::. NP_062 TEKP-----PVDIPAHEGVLSCIALNLQGTRIATASEKGTLIRIFDTSSGHLIQELRRGS 180 190 200 210 220 240 250 260 270 280 290 pF1KE1 DPATLYCINFSHDSSFLCASSDKGTVHIFALKDTRLNRRSALARVGKVGPMIGQYVDSQW . :..:::::..:.:..:.:::.::::::: .: . :..:.:: .. .. .: .:.: NP_062 QAANIYCINFNQDASLICVSSDHGTVHIFAAEDPKRNKQSSLASAS----FLPKYFSSKW 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE1 SLASFTVPAESACICAFGRNTSKNVNSVIAICVDGTFHKYVFTPDGNCNREAFDVYLDIC :...: ::. : :::::: . :.:::::.::...:..:.: :.: :... .:.. NP_062 SFSKFQVPSGSPCICAFGTEP----NAVIAICADGSYYKFLFNPKGECIRDVYAQFLEMT 290 300 310 320 330 340 360 pF1KE1 DDDDF :: NP_062 DDKL >>XP_016880351 (OMIM: 609226) PREDICTED: WD repeat domai (226 aa) initn: 592 init1: 359 opt: 767 Z-score: 858.8 bits: 166.8 E(85289): 4.2e-41 Smith-Waterman score: 767; 48.7% identity (77.5% similar) in 236 aa overlap (123-357:2-224) 100 110 120 130 140 150 pF1KE1 EKLVLEFTFTKPVLSVRMRHDKIVIVLKNRIYVYSFPDNPRKLFEFDTRDNPKGLCDLCP : :..: ::..: :.: :::::: ::: XP_016 MIKVFTFTHNPHQLHVFETCYNPKGLCVLCP 10 20 30 160 170 180 190 200 210 pF1KE1 SLEKQLLVFPGHKCGSLQLVDLAST-KPGTSSAPFTINAHQSDIACVSLNQPGTVVASAS . ...::.::: . : .:::::::: :: : : ::.. ..:..:: :: .:.:: XP_016 NSNNSLLAFPGTHTGHVQLVDLASTEKP-----PVDIPAHEGVLSCIALNLQGTRIATAS 40 50 60 70 80 220 230 240 250 260 270 pF1KE1 QKGTLIRLFDTQSKEKLVELRRGTDPATLYCINFSHDSSFLCASSDKGTVHIFALKDTRL .::::::.:::.: . . :::::.. :..:::::..:.:..:.:::.::::::: .: . XP_016 EKGTLIRIFDTSSGHLIQELRRGSQAANIYCINFNQDASLICVSSDHGTVHIFAAEDPKR 90 100 110 120 130 140 280 290 300 310 320 330 pF1KE1 NRRSALARVGKVGPMIGQYVDSQWSLASFTVPAESACICAFGRNTSKNVNSVIAICVDGT :..:.:: .. .. .: .:.::...: ::. : :::::: . :.:::::.::. XP_016 NKQSSLASAS----FLPKYFSSKWSFSKFQVPSGSPCICAFGTEP----NAVIAICADGS 150 160 170 180 190 340 350 360 pF1KE1 FHKYVFTPDGNCNREAFDVYLDICDDDDF ..:..:.: :.: :... .:.. :: XP_016 YYKFLFNPKGECIRDVYAQFLEMTDDKL 200 210 220 >>XP_016880352 (OMIM: 609226) PREDICTED: WD repeat domai (226 aa) initn: 592 init1: 359 opt: 767 Z-score: 858.8 bits: 166.8 E(85289): 4.2e-41 Smith-Waterman score: 767; 48.7% identity (77.5% similar) in 236 aa overlap (123-357:2-224) 100 110 120 130 140 150 pF1KE1 EKLVLEFTFTKPVLSVRMRHDKIVIVLKNRIYVYSFPDNPRKLFEFDTRDNPKGLCDLCP : :..: ::..: :.: :::::: ::: XP_016 MIKVFTFTHNPHQLHVFETCYNPKGLCVLCP 10 20 30 160 170 180 190 200 210 pF1KE1 SLEKQLLVFPGHKCGSLQLVDLAST-KPGTSSAPFTINAHQSDIACVSLNQPGTVVASAS . ...::.::: . : .:::::::: :: : : ::.. ..:..:: :: .:.:: XP_016 NSNNSLLAFPGTHTGHVQLVDLASTEKP-----PVDIPAHEGVLSCIALNLQGTRIATAS 40 50 60 70 80 220 230 240 250 260 270 pF1KE1 QKGTLIRLFDTQSKEKLVELRRGTDPATLYCINFSHDSSFLCASSDKGTVHIFALKDTRL .::::::.:::.: . . :::::.. :..:::::..:.:..:.:::.::::::: .: . XP_016 EKGTLIRIFDTSSGHLIQELRRGSQAANIYCINFNQDASLICVSSDHGTVHIFAAEDPKR 90 100 110 120 130 140 280 290 300 310 320 330 pF1KE1 NRRSALARVGKVGPMIGQYVDSQWSLASFTVPAESACICAFGRNTSKNVNSVIAICVDGT :..:.:: .. .. .: .:.::...: ::. : :::::: . :.:::::.::. XP_016 NKQSSLASAS----FLPKYFSSKWSFSKFQVPSGSPCICAFGTEP----NAVIAICADGS 150 160 170 180 190 340 350 360 pF1KE1 FHKYVFTPDGNCNREAFDVYLDICDDDDF ..:..:.: :.: :... .:.. :: XP_016 YYKFLFNPKGECIRDVYAQFLEMTDDKL 200 210 220 >>NP_001307701 (OMIM: 609224) WD repeat domain phosphoin (364 aa) initn: 240 init1: 152 opt: 356 Z-score: 401.4 bits: 82.9 E(85289): 1.3e-15 Smith-Waterman score: 356; 35.7% identity (67.0% similar) in 182 aa overlap (96-273:12-186) 70 80 90 100 110 120 pF1KE1 VGGGSSPKFSEISVLIWDDAREGKDSKEKLVLEFTFTKPVLSVRMRHDKIVIVLKNRIYV . ...... .::.:. ...... :.. ::. NP_001 MNVYHFKKGTEICNYSYSSNILSIRLNRQRLLVCLEESIYI 10 20 30 40 130 140 150 160 170 180 pF1KE1 YSFPDNPRKLFE--FDTRDNPKGLCDLCPSLEKQLLVFPGH-KCGSLQLVDLASTKPGTS ... : ::.. .: :: ::: : . .. :..:: : . : : : : NP_001 HNIKDM--KLLKTLLDIPANPTGLCALSINHSNSYLAYPGSLTSGEIVLYDGNSLK---- 50 60 70 80 90 190 200 210 220 230 240 pF1KE1 SAPFTINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDP-ATLY . :: ::.. .: ...: :. .::::.:::.::.:.. . .:: :.::: .:. NP_001 -TVCTIAAHEGTLAAITFNASGSKLASASEKGTVIRVFSVPDGQKLYEFRRGMKRYVTIS 100 110 120 130 140 150 250 260 270 280 290 300 pF1KE1 CINFSHDSSFLCASSDKGTVHIFALKDTRLNRRSALARVGKVGPMIGQYVDSQWSLASFT . :: ::.::::::. ::::: :... .: NP_001 SLVFSMDSQFLCASSNTETVHIFKLEQVTNSRPEEPSTWSGYMGKMFMAATNYLPTQVSD 160 170 180 190 200 210 310 320 330 340 350 360 pF1KE1 VPAESACICAFGRNTSKNVNSVIAICVDGTFHKYVFTPDGNCNREAFDVYLDICDDDDF NP_001 MMHQDRAFATARLNFSGQRNICTLSTIQKLPRLLVASSSGHLYMYNLDPQDGGECVLIKT 220 230 240 250 260 270 >>NP_060453 (OMIM: 609224) WD repeat domain phosphoinosi (446 aa) initn: 271 init1: 152 opt: 356 Z-score: 400.2 bits: 82.9 E(85289): 1.5e-15 Smith-Waterman score: 395; 30.3% identity (63.8% similar) in 271 aa overlap (9-273:17-268) 10 20 30 40 50 pF1KE1 MTQQPLRGVTSLRFNQDQSCFCCAMETGVRIYNVEPL--MEKGHLDHEQVGS .. . :::: . . . ..: ..... . ... : ..: . . NP_060 MEAEAADAPPGGVESALSCFSFNQDCTSLATGTKAGYKLFSLSSVEQLDQVHGSNE-IPD 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 MGLVEMLHRSNLLALVGGGSSPKFSEISVLIWDDAREGKDSKEKLVLEFTFTKPVLSVRM . .:: : :.:...: : : ...: . ..: . . ...... .::.:. NP_060 VYIVERLFSSSLVVVV---SHTKPRQMNVYHF---KKGTE-----ICNYSYSSNILSIRL 60 70 80 90 100 120 130 140 150 160 pF1KE1 RHDKIVIVLKNRIYVYSFPDNPRKLFE--FDTRDNPKGLCDLCPSLEKQLLVFPGH-KCG ...... :.. ::.... : ::.. .: :: ::: : . .. :..:: : NP_060 NRQRLLVCLEESIYIHNIKDM--KLLKTLLDIPANPTGLCALSINHSNSYLAYPGSLTSG 110 120 130 140 150 160 170 180 190 200 210 220 pF1KE1 SLQLVDLASTKPGTSSAPFTINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEK . : : : : . :: ::.. .: ...: :. .::::.:::.::.:.. . .: NP_060 EIVLYDGNSLK-----TVCTIAAHEGTLAAITFNASGSKLASASEKGTVIRVFSVPDGQK 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE1 LVELRRGTDP-ATLYCINFSHDSSFLCASSDKGTVHIFALKDTRLNRRSALARVGKVGPM : :.::: .:. . :: ::.::::::. ::::: :... .: NP_060 LYEFRRGMKRYVTISSLVFSMDSQFLCASSNTETVHIFKLEQVTNSRPEEPSTWSGYMGK 230 240 250 260 270 280 290 300 310 320 330 340 pF1KE1 IGQYVDSQWSLASFTVPAESACICAFGRNTSKNVNSVIAICVDGTFHKYVFTPDGNCNRE NP_060 MFMAATNYLPTQVSDMMHQDRAFATARLNFSGQRNICTLSTIQKLPRLLVASSSGHLYMY 290 300 310 320 330 340 >>NP_001028692 (OMIM: 609225) WD repeat domain phosphoin (384 aa) initn: 260 init1: 138 opt: 319 Z-score: 360.2 bits: 75.3 E(85289): 2.5e-13 Smith-Waterman score: 335; 26.6% identity (57.1% similar) in 308 aa overlap (53-343:19-308) 30 40 50 60 70 80 pF1KE1 CAMETGVRIYNVEPLMEKGHLDHEQVGSMGLVEMLHRSNLLALVGGGSSPKFSEISVLIW .:: : :.:.:.:. ..:. .. . NP_001 MFTHVLPFVISADTEDVCIVERLFSSSLVAIVSL-KAPRKLKVCHF-- 10 20 30 40 90 100 110 120 130 140 pF1KE1 DDAREGKDSKEKLVLEFTFTKPVLSVRMRHDKIVIVLKNRIYVYSFPDNPRKLFEFDTRD ..: . . ...... .:.:.. ...... :.. .:.... : .: NP_001 ---KKGTE-----ICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPP 50 60 70 80 90 150 160 170 180 190 200 pF1KE1 NPKGLCDLCPSLEKQLLVFPGHKC-GSLQLVDLASTKPGTSSAPFTINAHQSDIACVSLN :: ::: : . .. :..:: : .:. : . . : : ::.: .: .... NP_001 NPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLR-----AANMIPAHDSPLAALAFD 100 110 120 130 140 150 210 220 230 240 250 260 pF1KE1 QPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPATLYC-INFSHDSSFLCASSDKGT :: .:.::.:::.::.:. .:: :.:::. . : . :: :. :: :::. : NP_001 ASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTET 160 170 180 190 200 210 270 280 290 300 pF1KE1 VHIFALKDTRLNR----RSALARVGKVGPMIGQYVDSQWS--------LASFTVP-AESA :::: :. .. . . . ::: .:. :: . .:. .: NP_001 VHIFKLETVKEKPPEEPTTWTGYFGKVLMASTSYLPSQVTEMFNQGRAFATVRLPFCGHK 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE1 CICAFGRNTSKNVNSVIAICVDGTFHKYVFTPD--GNCNREAFDVYLDICDDDDF ::... : ... ... .:: .. : . :. :.: NP_001 NICSLA--TIQKIPRLLVGAADGYLYMYNLDPQEGGECALMKQHRLDGSLETTNEILDSA 280 290 300 310 320 330 NP_001 SHDCPLVTQTYGAAAGKAYTDDLGAVGGACLEDEASALRLDEDSEHPPMILRTD 340 350 360 370 380 >>NP_001028691 (OMIM: 609225) WD repeat domain phosphoin (425 aa) initn: 293 init1: 138 opt: 319 Z-score: 359.6 bits: 75.3 E(85289): 2.7e-13 Smith-Waterman score: 359; 25.9% identity (57.3% similar) in 351 aa overlap (14-343:20-349) 10 20 30 40 50 pF1KE1 MTQQPLRGVTSLRFNQDQSCFCCAMETGVRIYNVEPL--MEKGH--LDHEQVGS ::::.. . . ..: ..... . .:. . : :.: NP_001 MNLASQSGEAGAGQLLFANFNQDNTSLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDV-- 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 MGLVEMLHRSNLLALVGGGSSPKFSEISVLIWDDAREGKDSKEKLVLEFTFTKPVLSVRM .:: : :.:.:.:. ..:. .. . ..: . . ...... .:.:.. NP_001 -CIVERLFSSSLVAIVSL-KAPRKLKVCHF-----KKGTE-----ICNYSYSNTILAVKL 60 70 80 90 100 120 130 140 150 160 pF1KE1 RHDKIVIVLKNRIYVYSFPDNPRKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGHKC-GSL ...... :.. .:.... : .: :: ::: : . .. :..:: : . NP_001 NRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEV 110 120 130 140 150 160 170 180 190 200 210 220 pF1KE1 QLVDLASTKPGTSSAPFTINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLV :. : . . : : ::.: .: .... :: .:.::.:::.::.:. .:: NP_001 QVFDTINLR-----AANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLF 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE1 ELRRGTDPATLYC-INFSHDSSFLCASSDKGTVHIFALKDTRLNR----RSALARVGKVG :.:::. . : . :: :. :: :::. ::::: :. .. . . . ::: NP_001 EFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVL 230 240 250 260 270 280 290 300 310 320 330 pF1KE1 PMIGQYVDSQWS--------LASFTVP-AESACICAFGRNTSKNVNSVIAICVDGTFHKY .:. :: . .:. .: ::... : ... ... .:: .. : NP_001 MASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLA--TIQKIPRLLVGAADGYLYMY 290 300 310 320 330 340 350 360 pF1KE1 VFTPD--GNCNREAFDVYLDICDDDDF . :. :.: NP_001 NLDPQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGKAYTDDLGAVGG 340 350 360 370 380 390 360 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 19:08:02 2016 done: Sat Nov 5 19:08:04 2016 Total Scan time: 8.090 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]