FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1136, 357 aa 1>>>pF1KE1136 357 - 357 aa - 357 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.8515+/-0.00094; mu= 13.3608+/- 0.056 mean_var=73.0348+/-15.485, 0's: 0 Z-trim(105.2): 26 B-trim: 515 in 1/46 Lambda= 0.150075 statistics sampled from 8280 (8298) to 8280 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.63), E-opt: 0.2 (0.255), width: 16 Scan time: 2.590 The best scores are: opt bits E(32554) CCDS8657.1 GPRC5A gene_id:9052|Hs108|chr12 ( 357) 2379 524.5 5.3e-149 CCDS8658.1 GPRC5D gene_id:55507|Hs108|chr12 ( 345) 957 216.6 2.5e-56 CCDS10581.1 GPRC5B gene_id:51704|Hs108|chr16 ( 403) 652 150.6 2.1e-36 CCDS42378.1 GPRC5C gene_id:55890|Hs108|chr17 ( 453) 478 113.0 5.2e-25 CCDS11699.1 GPRC5C gene_id:55890|Hs108|chr17 ( 486) 478 113.0 5.5e-25 >>CCDS8657.1 GPRC5A gene_id:9052|Hs108|chr12 (357 aa) initn: 2379 init1: 2379 opt: 2379 Z-score: 2788.5 bits: 524.5 E(32554): 5.3e-149 Smith-Waterman score: 2379; 100.0% identity (100.0% similar) in 357 aa overlap (1-357:1-357) 10 20 30 40 50 60 pF1KE1 MATTVPDGCRNGLKSKYYRLCDKAEAWGIVLETVATAGVVTSVAFMLTLPILVCKVQDSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS86 MATTVPDGCRNGLKSKYYRLCDKAEAWGIVLETVATAGVVTSVAFMLTLPILVCKVQDSN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 RRKMLPTQFLFLLGVLGIFGLTFAFIIGLDGSTGPTRFFLFGILFSICFSCLLAHAVSLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS86 RRKMLPTQFLFLLGVLGIFGLTFAFIIGLDGSTGPTRFFLFGILFSICFSCLLAHAVSLT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 KLVRGRKPLSLLVILGLAVGFSLVQDVIAIEYIVLTMNRTNVNVFSELSAPRRNEDFVLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS86 KLVRGRKPLSLLVILGLAVGFSLVQDVIAIEYIVLTMNRTNVNVFSELSAPRRNEDFVLL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 LTYVLFLMALTFLMSSFTFCGSFTGWKRHGAHIYLTMLLSIAIWVAWITLLMLPDFDRRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS86 LTYVLFLMALTFLMSSFTFCGSFTGWKRHGAHIYLTMLLSIAIWVAWITLLMLPDFDRRW 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 DDTILSSALAANGWVFLLAYVSPEFWLLTKQRNPMDYPVEDAFCKPQLVKKSYGVENRAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS86 DDTILSSALAANGWVFLLAYVSPEFWLLTKQRNPMDYPVEDAFCKPQLVKKSYGVENRAY 250 260 270 280 290 300 310 320 330 340 350 pF1KE1 SQEEITQGFEETGDTLYAPYSTHFQLQNQPPQKEFSIPRAHAWPSPYKDYEVKKEGS ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS86 SQEEITQGFEETGDTLYAPYSTHFQLQNQPPQKEFSIPRAHAWPSPYKDYEVKKEGS 310 320 330 340 350 >>CCDS8658.1 GPRC5D gene_id:55507|Hs108|chr12 (345 aa) initn: 886 init1: 507 opt: 957 Z-score: 1124.8 bits: 216.6 E(32554): 2.5e-56 Smith-Waterman score: 957; 45.7% identity (74.2% similar) in 337 aa overlap (17-349:12-341) 10 20 30 40 50 60 pF1KE1 MATTVPDGCRNGLKSKYYRLCDKAEAWGIVLETVATAGVVTSVAFMLTLPILVCKVQDSN :. ::: :::.::..: :.:... ..:.. .:. :.:: . CCDS86 MYKDCIESTGDYFLLCDAEGPWGIILESLAILGIVVTILLLLAFLFLMRKIQDCS 10 20 30 40 50 70 80 90 100 110 120 pF1KE1 RRKMLPTQFLFLLGVLGIFGLTFAFIIGLDGSTGPTRFFLFGILFSICFSCLLAHAVSLT . ..::::.::::.:::.:::.::::: :. .:.:.:.::::.::..::::::::: .:. CCDS86 QWNVLPTQLLFLLSVLGLFGLAFAFIIELNQQTAPVRYFLFGVLFALCFSCLLAHASNLV 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE1 KLVRGRKPLSLLVILGLAVGFSLVQDVIAIEYIVLTMNRTNVNVFSELSAPRRNEDFVLL ::::: .: .:: .:.: ::.: .:: ::..: :.: .: ... . : :::.: CCDS86 KLVRGCVSFSWTTILCIAIGCSLLQIIIATEYVTLIMTRGM--MFVNMTPCQLNVDFVVL 120 130 140 150 160 170 190 200 210 220 230 pF1KE1 LTYVLFLMALTFLMSSFTFCGSFTGWKRHGAHIYLTMLLSIAIWVAWITLLML--PDFDR :.::::::::::..:. :::: .::.:: :..:.:.:: :::.::..:. :.:.: CCDS86 LVYVLFLMALTFFVSKATFCGPCENWKQHGRLIFITVLFSIIIWVVWISMLLRGNPQFQR 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE1 R--WDDTILSSALAANGWVFLLAYVSPEFWLLTKQRNPMDYPVEDAFCKPQLVKKSYGVE . ::: .. ::..:.::::: :. ::. .: .. .. :.. : ..:. :: CCDS86 QPQWDDPVVCIALVTNAWVFLLLYIVPELCILYRS-CRQECPLQGNACPVTAYQHSFQVE 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE1 NRAYSQEEITQGFEETGDTLYAPYSTHFQLQNQPPQKEFSIPRAHAWPSPYKDYEVKKEG :. :. . ..: :: :. . :.: .: :. : .: ::.:. :: .: CCDS86 NQELSRARDSDGAEE--DVALTSYGTPIQPQTVDPTQECFIPQAKL--SPQQDAGGV 300 310 320 330 340 pF1KE1 S >>CCDS10581.1 GPRC5B gene_id:51704|Hs108|chr16 (403 aa) initn: 586 init1: 404 opt: 652 Z-score: 766.9 bits: 150.6 E(32554): 2.1e-36 Smith-Waterman score: 670; 37.4% identity (66.4% similar) in 321 aa overlap (8-313:36-349) 10 20 30 pF1KE1 MATTVPDGCRNGLKSKYYRLCDKAEAWGIVLETVATA :: : .: ::: ::::.:.:: : CCDS10 ERKMRAHQVLTFLLLFVITSVASENASTSRGCGLDLLPQYVSLCDLDAIWGIVVEAVAGA 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE1 GVVTSVAFMLTLPILVCKVQDSNRRKMLPTQFLFLLGVLGIFGLTFAFIIGLDGSTGPTR :.. .. .:: : . . ........ . .::::::.::.::::::::: : . .: CCDS10 GALITLLLMLILLVRLPFIKEKEKKSPVGLHFLFLLGTLGLFGLTFAFIIQEDETICSVR 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE1 FFLFGILFSICFSCLLAHAVSLTKLVR-GRKPLSLLVILGLAVGFSLVQDVIAIEYIVLT ::.:.::..::::::..: . .::: : : . .. :::. . ::: .::.:..::: CCDS10 RFLWGVLFALCFSCLLSQAWRVRRLVRHGTGPAGWQLV-GLALCLMLVQVIIAVEWLVLT 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE1 MNRTNVNVFSELSAPRRNEDFVLLLTYVLFLMALTFLMSSFTFCGSFTGWKRHGAHIYLT . : .. . . :::. : : . :...:. .. ::.::.: :: .:: . .: CCDS10 VLRD-----TRPACAYEPMDFVMALIYDMVLLVVTLGLALFTLCGKFKRWKLNGAFLLIT 190 200 210 220 230 220 230 240 250 260 pF1KE1 MLLSIAIWVAWITLLMLPDFDRR----WDDTILSSALAANGWVFLLAYVSPEF---WLLT .::. :::::.:. .. . . :.: :. .:::.::::.. .. ::. : . CCDS10 AFLSVLIWVAWMTMYLFGNVKLQQGDAWNDPTLAITLAASGWVFVIFHAIPEIHCTLLPA 240 250 260 270 280 290 270 280 290 300 310 320 pF1KE1 KQRNPMDY-----PV--EDAFCKPQLVKKSYGVENRAYSQEEITQGFEETGDTLYAPYST :.: .: : : :: . . ..: .::.:.:..: . ... .: CCDS10 LQENTPNYFDTSQPRMRETAFEEDVQLPRAY-MENKAFSMDEHNAALRTAGFPNGSLGKR 300 310 320 330 340 350 330 340 350 pF1KE1 HFQLQNQPPQKEFSIPRAHAWPSPYKDYEVKKEGS CCDS10 PSGSLGKRPSAPFRSNVYQPTEMAVVLNGGTIPTAPPSHTGRHLW 360 370 380 390 400 >>CCDS42378.1 GPRC5C gene_id:55890|Hs108|chr17 (453 aa) initn: 752 init1: 456 opt: 478 Z-score: 562.5 bits: 113.0 E(32554): 5.2e-25 Smith-Waterman score: 718; 38.5% identity (64.7% similar) in 374 aa overlap (5-342:39-408) 10 20 30 pF1KE1 MATTVPDGCRNGLKSKYYRLCDKAEAWGIVLETV :: :: .::. :: :::.. :::::::.: CCDS42 LGARMAIHKALVMCLGLPLFLFPGAWAQGHVPPGCSQGLNPLYYNLCDRSGAWGIVLEAV 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE1 ATAGVVTSVAFMLTLPILVCK---VQDSNRRKMLPTQFLFLLGVLGIFGLTFAFIIGLDG : ::.::. :.::. ::: . :::...:..: :: .::::.::.: :.:: .. : CCDS42 AGAGIVTT--FVLTI-ILVASLPFVQDTKKRSLLGTQVFFLLGTLGLFCLVFACVVKPDF 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE1 STGPTRFFLFGILFSICFSCLLAHAVSLTKLVRGRKPLSLLVILGLAVGFSLVQDVIAIE :: .: ::::.::.:::::: ::. .:. :.: . ::. .:. ..::. .: : CCDS42 STCASRRFLFGVLFAICFSCLAAHVFALNFLARKNHGPRGWVIFTVALLLTLVEVIINTE 130 140 150 160 170 180 160 170 180 190 200 pF1KE1 YIVLTMNRT--------NVNVFSELSAPRR--NEDFVLLLTYVLFLMALTFLMSSFTFCG ....:. : : .. ...: : :::. : ::..:. .:: . ..:: CCDS42 WLIITLVRGSGEGGPQGNSSAGWAVASPCAIANMDFVMALIYVMLLLLGAFLGAWPALCG 190 200 210 220 230 240 210 220 230 240 250 pF1KE1 SFTGWKRHGAHIYLTMLLSIAIWVAWITLLMLPDFDRR---WDDTILSSALAANGWVFLL . :..::. . :: :.::::.::.. . .. ::: :. :::::.:.:.: CCDS42 RYKRWRKHGVFVLLTTATSVAIWVVWIVMYTYGNKQHNSPTWDDPTLAIALAANAWAFVL 250 260 270 280 290 300 260 270 280 290 300 pF1KE1 AYVSPEFWLLTK----QRNPMD-YPVE----DAFCKPQLVKKSYGVENRAYSQEE----- :: :: .:: : : ::.. ... : : .:. :::.:.:..: CCDS42 FYVIPEVSQVTKSSPEQSYQGDMYPTRGVGYETILKEQK-GQSMFVENKAFSMDEPVAAK 310 320 330 340 350 360 310 320 330 340 350 pF1KE1 --ITQGFEETGDTLYAPYS-THFQLQNQPPQK---EFSIPRAHAWPSPYKDYEVKKEGS .. .:. : . :. :.. :... :.. .. .::: : CCDS42 RPVSPYSGYNGQLLTSVYQPTEMALMHKVPSEGAYDIILPRATANSQVMGSANSTLRAED 370 380 390 400 410 420 CCDS42 MYSAQSHQAATPPKDGKNSQVFRNPYVWD 430 440 450 >>CCDS11699.1 GPRC5C gene_id:55890|Hs108|chr17 (486 aa) initn: 752 init1: 456 opt: 478 Z-score: 562.0 bits: 113.0 E(32554): 5.5e-25 Smith-Waterman score: 718; 38.5% identity (64.7% similar) in 374 aa overlap (5-342:72-441) 10 20 30 pF1KE1 MATTVPDGCRNGLKSKYYRLCDKAEAWGIVLETV :: :: .::. :: :::.. :::::::.: CCDS11 LGARMAIHKALVMCLGLPLFLFPGAWAQGHVPPGCSQGLNPLYYNLCDRSGAWGIVLEAV 50 60 70 80 90 100 40 50 60 70 80 90 pF1KE1 ATAGVVTSVAFMLTLPILVCK---VQDSNRRKMLPTQFLFLLGVLGIFGLTFAFIIGLDG : ::.::. :.::. ::: . :::...:..: :: .::::.::.: :.:: .. : CCDS11 AGAGIVTT--FVLTI-ILVASLPFVQDTKKRSLLGTQVFFLLGTLGLFCLVFACVVKPDF 110 120 130 140 150 100 110 120 130 140 150 pF1KE1 STGPTRFFLFGILFSICFSCLLAHAVSLTKLVRGRKPLSLLVILGLAVGFSLVQDVIAIE :: .: ::::.::.:::::: ::. .:. :.: . ::. .:. ..::. .: : CCDS11 STCASRRFLFGVLFAICFSCLAAHVFALNFLARKNHGPRGWVIFTVALLLTLVEVIINTE 160 170 180 190 200 210 160 170 180 190 200 pF1KE1 YIVLTMNRT--------NVNVFSELSAPRR--NEDFVLLLTYVLFLMALTFLMSSFTFCG ....:. : : .. ...: : :::. : ::..:. .:: . ..:: CCDS11 WLIITLVRGSGEGGPQGNSSAGWAVASPCAIANMDFVMALIYVMLLLLGAFLGAWPALCG 220 230 240 250 260 270 210 220 230 240 250 pF1KE1 SFTGWKRHGAHIYLTMLLSIAIWVAWITLLMLPDFDRR---WDDTILSSALAANGWVFLL . :..::. . :: :.::::.::.. . .. ::: :. :::::.:.:.: CCDS11 RYKRWRKHGVFVLLTTATSVAIWVVWIVMYTYGNKQHNSPTWDDPTLAIALAANAWAFVL 280 290 300 310 320 330 260 270 280 290 300 pF1KE1 AYVSPEFWLLTK----QRNPMD-YPVE----DAFCKPQLVKKSYGVENRAYSQEE----- :: :: .:: : : ::.. ... : : .:. :::.:.:..: CCDS11 FYVIPEVSQVTKSSPEQSYQGDMYPTRGVGYETILKEQK-GQSMFVENKAFSMDEPVAAK 340 350 360 370 380 390 310 320 330 340 350 pF1KE1 --ITQGFEETGDTLYAPYS-THFQLQNQPPQK---EFSIPRAHAWPSPYKDYEVKKEGS .. .:. : . :. :.. :... :.. .. .::: : CCDS11 RPVSPYSGYNGQLLTSVYQPTEMALMHKVPSEGAYDIILPRATANSQVMGSANSTLRAED 400 410 420 430 440 450 CCDS11 MYSAQSHQAATPPKDGKNSQVFRNPYVWD 460 470 480 357 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 14:55:58 2016 done: Sun Nov 6 14:55:59 2016 Total Scan time: 2.590 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]