FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1136, 357 aa 1>>>pF1KE1136 357 - 357 aa - 357 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2268+/-0.000413; mu= 16.9742+/- 0.025 mean_var=78.5444+/-15.989, 0's: 0 Z-trim(111.1): 57 B-trim: 0 in 0/51 Lambda= 0.144716 statistics sampled from 19583 (19630) to 19583 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.599), E-opt: 0.2 (0.23), width: 16 Scan time: 6.550 The best scores are: opt bits E(85289) NP_003970 (OMIM: 604138) retinoic acid-induced pro ( 357) 2379 506.6 3.3e-143 NP_061124 (OMIM: 607437) G-protein coupled recepto ( 345) 957 209.7 7.6e-54 XP_005253478 (OMIM: 607437) PREDICTED: G-protein c ( 345) 957 209.7 7.6e-54 XP_016875071 (OMIM: 607437) PREDICTED: G-protein c ( 345) 957 209.7 7.6e-54 XP_016875072 (OMIM: 607437) PREDICTED: G-protein c ( 300) 897 197.2 4e-50 XP_006721114 (OMIM: 605948) PREDICTED: G-protein c ( 403) 652 146.1 1.3e-34 NP_057319 (OMIM: 605948) G-protein coupled recepto ( 403) 652 146.1 1.3e-34 XP_006721115 (OMIM: 605948) PREDICTED: G-protein c ( 403) 652 146.1 1.3e-34 NP_001291700 (OMIM: 605948) G-protein coupled rece ( 534) 652 146.2 1.6e-34 NP_061123 (OMIM: 605949) G-protein coupled recepto ( 453) 478 109.8 1.2e-23 NP_071319 (OMIM: 605949) G-protein coupled recepto ( 486) 478 109.9 1.3e-23 XP_005257571 (OMIM: 605949) PREDICTED: G-protein c ( 496) 478 109.9 1.3e-23 XP_016880345 (OMIM: 605949) PREDICTED: G-protein c ( 541) 478 109.9 1.4e-23 XP_016880344 (OMIM: 605949) PREDICTED: G-protein c ( 542) 478 109.9 1.4e-23 XP_005257569 (OMIM: 605949) PREDICTED: G-protein c ( 551) 478 109.9 1.4e-23 >>NP_003970 (OMIM: 604138) retinoic acid-induced protein (357 aa) initn: 2379 init1: 2379 opt: 2379 Z-score: 2692.0 bits: 506.6 E(85289): 3.3e-143 Smith-Waterman score: 2379; 100.0% identity (100.0% similar) in 357 aa overlap (1-357:1-357) 10 20 30 40 50 60 pF1KE1 MATTVPDGCRNGLKSKYYRLCDKAEAWGIVLETVATAGVVTSVAFMLTLPILVCKVQDSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MATTVPDGCRNGLKSKYYRLCDKAEAWGIVLETVATAGVVTSVAFMLTLPILVCKVQDSN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 RRKMLPTQFLFLLGVLGIFGLTFAFIIGLDGSTGPTRFFLFGILFSICFSCLLAHAVSLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 RRKMLPTQFLFLLGVLGIFGLTFAFIIGLDGSTGPTRFFLFGILFSICFSCLLAHAVSLT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 KLVRGRKPLSLLVILGLAVGFSLVQDVIAIEYIVLTMNRTNVNVFSELSAPRRNEDFVLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 KLVRGRKPLSLLVILGLAVGFSLVQDVIAIEYIVLTMNRTNVNVFSELSAPRRNEDFVLL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 LTYVLFLMALTFLMSSFTFCGSFTGWKRHGAHIYLTMLLSIAIWVAWITLLMLPDFDRRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LTYVLFLMALTFLMSSFTFCGSFTGWKRHGAHIYLTMLLSIAIWVAWITLLMLPDFDRRW 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 DDTILSSALAANGWVFLLAYVSPEFWLLTKQRNPMDYPVEDAFCKPQLVKKSYGVENRAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 DDTILSSALAANGWVFLLAYVSPEFWLLTKQRNPMDYPVEDAFCKPQLVKKSYGVENRAY 250 260 270 280 290 300 310 320 330 340 350 pF1KE1 SQEEITQGFEETGDTLYAPYSTHFQLQNQPPQKEFSIPRAHAWPSPYKDYEVKKEGS ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SQEEITQGFEETGDTLYAPYSTHFQLQNQPPQKEFSIPRAHAWPSPYKDYEVKKEGS 310 320 330 340 350 >>NP_061124 (OMIM: 607437) G-protein coupled receptor fa (345 aa) initn: 886 init1: 507 opt: 957 Z-score: 1087.7 bits: 209.7 E(85289): 7.6e-54 Smith-Waterman score: 957; 45.7% identity (74.2% similar) in 337 aa overlap (17-349:12-341) 10 20 30 40 50 60 pF1KE1 MATTVPDGCRNGLKSKYYRLCDKAEAWGIVLETVATAGVVTSVAFMLTLPILVCKVQDSN :. ::: :::.::..: :.:... ..:.. .:. :.:: . NP_061 MYKDCIESTGDYFLLCDAEGPWGIILESLAILGIVVTILLLLAFLFLMRKIQDCS 10 20 30 40 50 70 80 90 100 110 120 pF1KE1 RRKMLPTQFLFLLGVLGIFGLTFAFIIGLDGSTGPTRFFLFGILFSICFSCLLAHAVSLT . ..::::.::::.:::.:::.::::: :. .:.:.:.::::.::..::::::::: .:. NP_061 QWNVLPTQLLFLLSVLGLFGLAFAFIIELNQQTAPVRYFLFGVLFALCFSCLLAHASNLV 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE1 KLVRGRKPLSLLVILGLAVGFSLVQDVIAIEYIVLTMNRTNVNVFSELSAPRRNEDFVLL ::::: .: .:: .:.: ::.: .:: ::..: :.: .: ... . : :::.: NP_061 KLVRGCVSFSWTTILCIAIGCSLLQIIIATEYVTLIMTRGM--MFVNMTPCQLNVDFVVL 120 130 140 150 160 170 190 200 210 220 230 pF1KE1 LTYVLFLMALTFLMSSFTFCGSFTGWKRHGAHIYLTMLLSIAIWVAWITLLML--PDFDR :.::::::::::..:. :::: .::.:: :..:.:.:: :::.::..:. :.:.: NP_061 LVYVLFLMALTFFVSKATFCGPCENWKQHGRLIFITVLFSIIIWVVWISMLLRGNPQFQR 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE1 R--WDDTILSSALAANGWVFLLAYVSPEFWLLTKQRNPMDYPVEDAFCKPQLVKKSYGVE . ::: .. ::..:.::::: :. ::. .: .. .. :.. : ..:. :: NP_061 QPQWDDPVVCIALVTNAWVFLLLYIVPELCILYRS-CRQECPLQGNACPVTAYQHSFQVE 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE1 NRAYSQEEITQGFEETGDTLYAPYSTHFQLQNQPPQKEFSIPRAHAWPSPYKDYEVKKEG :. :. . ..: :: :. . :.: .: :. : .: ::.:. :: .: NP_061 NQELSRARDSDGAEE--DVALTSYGTPIQPQTVDPTQECFIPQAKL--SPQQDAGGV 300 310 320 330 340 pF1KE1 S >>XP_005253478 (OMIM: 607437) PREDICTED: G-protein coupl (345 aa) initn: 886 init1: 507 opt: 957 Z-score: 1087.7 bits: 209.7 E(85289): 7.6e-54 Smith-Waterman score: 957; 45.7% identity (74.2% similar) in 337 aa overlap (17-349:12-341) 10 20 30 40 50 60 pF1KE1 MATTVPDGCRNGLKSKYYRLCDKAEAWGIVLETVATAGVVTSVAFMLTLPILVCKVQDSN :. ::: :::.::..: :.:... ..:.. .:. :.:: . XP_005 MYKDCIESTGDYFLLCDAEGPWGIILESLAILGIVVTILLLLAFLFLMRKIQDCS 10 20 30 40 50 70 80 90 100 110 120 pF1KE1 RRKMLPTQFLFLLGVLGIFGLTFAFIIGLDGSTGPTRFFLFGILFSICFSCLLAHAVSLT . ..::::.::::.:::.:::.::::: :. .:.:.:.::::.::..::::::::: .:. XP_005 QWNVLPTQLLFLLSVLGLFGLAFAFIIELNQQTAPVRYFLFGVLFALCFSCLLAHASNLV 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE1 KLVRGRKPLSLLVILGLAVGFSLVQDVIAIEYIVLTMNRTNVNVFSELSAPRRNEDFVLL ::::: .: .:: .:.: ::.: .:: ::..: :.: .: ... . : :::.: XP_005 KLVRGCVSFSWTTILCIAIGCSLLQIIIATEYVTLIMTRGM--MFVNMTPCQLNVDFVVL 120 130 140 150 160 170 190 200 210 220 230 pF1KE1 LTYVLFLMALTFLMSSFTFCGSFTGWKRHGAHIYLTMLLSIAIWVAWITLLML--PDFDR :.::::::::::..:. :::: .::.:: :..:.:.:: :::.::..:. :.:.: XP_005 LVYVLFLMALTFFVSKATFCGPCENWKQHGRLIFITVLFSIIIWVVWISMLLRGNPQFQR 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE1 R--WDDTILSSALAANGWVFLLAYVSPEFWLLTKQRNPMDYPVEDAFCKPQLVKKSYGVE . ::: .. ::..:.::::: :. ::. .: .. .. :.. : ..:. :: XP_005 QPQWDDPVVCIALVTNAWVFLLLYIVPELCILYRS-CRQECPLQGNACPVTAYQHSFQVE 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE1 NRAYSQEEITQGFEETGDTLYAPYSTHFQLQNQPPQKEFSIPRAHAWPSPYKDYEVKKEG :. :. . ..: :: :. . :.: .: :. : .: ::.:. :: .: XP_005 NQELSRARDSDGAEE--DVALTSYGTPIQPQTVDPTQECFIPQAKL--SPQQDAGGV 300 310 320 330 340 pF1KE1 S >>XP_016875071 (OMIM: 607437) PREDICTED: G-protein coupl (345 aa) initn: 886 init1: 507 opt: 957 Z-score: 1087.7 bits: 209.7 E(85289): 7.6e-54 Smith-Waterman score: 957; 45.7% identity (74.2% similar) in 337 aa overlap (17-349:12-341) 10 20 30 40 50 60 pF1KE1 MATTVPDGCRNGLKSKYYRLCDKAEAWGIVLETVATAGVVTSVAFMLTLPILVCKVQDSN :. ::: :::.::..: :.:... ..:.. .:. :.:: . XP_016 MYKDCIESTGDYFLLCDAEGPWGIILESLAILGIVVTILLLLAFLFLMRKIQDCS 10 20 30 40 50 70 80 90 100 110 120 pF1KE1 RRKMLPTQFLFLLGVLGIFGLTFAFIIGLDGSTGPTRFFLFGILFSICFSCLLAHAVSLT . ..::::.::::.:::.:::.::::: :. .:.:.:.::::.::..::::::::: .:. XP_016 QWNVLPTQLLFLLSVLGLFGLAFAFIIELNQQTAPVRYFLFGVLFALCFSCLLAHASNLV 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE1 KLVRGRKPLSLLVILGLAVGFSLVQDVIAIEYIVLTMNRTNVNVFSELSAPRRNEDFVLL ::::: .: .:: .:.: ::.: .:: ::..: :.: .: ... . : :::.: XP_016 KLVRGCVSFSWTTILCIAIGCSLLQIIIATEYVTLIMTRGM--MFVNMTPCQLNVDFVVL 120 130 140 150 160 170 190 200 210 220 230 pF1KE1 LTYVLFLMALTFLMSSFTFCGSFTGWKRHGAHIYLTMLLSIAIWVAWITLLML--PDFDR :.::::::::::..:. :::: .::.:: :..:.:.:: :::.::..:. :.:.: XP_016 LVYVLFLMALTFFVSKATFCGPCENWKQHGRLIFITVLFSIIIWVVWISMLLRGNPQFQR 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE1 R--WDDTILSSALAANGWVFLLAYVSPEFWLLTKQRNPMDYPVEDAFCKPQLVKKSYGVE . ::: .. ::..:.::::: :. ::. .: .. .. :.. : ..:. :: XP_016 QPQWDDPVVCIALVTNAWVFLLLYIVPELCILYRS-CRQECPLQGNACPVTAYQHSFQVE 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE1 NRAYSQEEITQGFEETGDTLYAPYSTHFQLQNQPPQKEFSIPRAHAWPSPYKDYEVKKEG :. :. . ..: :: :. . :.: .: :. : .: ::.:. :: .: XP_016 NQELSRARDSDGAEE--DVALTSYGTPIQPQTVDPTQECFIPQAKL--SPQQDAGGV 300 310 320 330 340 pF1KE1 S >>XP_016875072 (OMIM: 607437) PREDICTED: G-protein coupl (300 aa) initn: 886 init1: 507 opt: 897 Z-score: 1020.8 bits: 197.2 E(85289): 4e-50 Smith-Waterman score: 897; 47.4% identity (76.6% similar) in 291 aa overlap (17-303:12-299) 10 20 30 40 50 60 pF1KE1 MATTVPDGCRNGLKSKYYRLCDKAEAWGIVLETVATAGVVTSVAFMLTLPILVCKVQDSN :. ::: :::.::..: :.:... ..:.. .:. :.:: . XP_016 MYKDCIESTGDYFLLCDAEGPWGIILESLAILGIVVTILLLLAFLFLMRKIQDCS 10 20 30 40 50 70 80 90 100 110 120 pF1KE1 RRKMLPTQFLFLLGVLGIFGLTFAFIIGLDGSTGPTRFFLFGILFSICFSCLLAHAVSLT . ..::::.::::.:::.:::.::::: :. .:.:.:.::::.::..::::::::: .:. XP_016 QWNVLPTQLLFLLSVLGLFGLAFAFIIELNQQTAPVRYFLFGVLFALCFSCLLAHASNLV 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE1 KLVRGRKPLSLLVILGLAVGFSLVQDVIAIEYIVLTMNRTNVNVFSELSAPRRNEDFVLL ::::: .: .:: .:.: ::.: .:: ::..: :.: .: ... . : :::.: XP_016 KLVRGCVSFSWTTILCIAIGCSLLQIIIATEYVTLIMTRGM--MFVNMTPCQLNVDFVVL 120 130 140 150 160 170 190 200 210 220 230 pF1KE1 LTYVLFLMALTFLMSSFTFCGSFTGWKRHGAHIYLTMLLSIAIWVAWITLLML--PDFDR :.::::::::::..:. :::: .::.:: :..:.:.:: :::.::..:. :.:.: XP_016 LVYVLFLMALTFFVSKATFCGPCENWKQHGRLIFITVLFSIIIWVVWISMLLRGNPQFQR 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE1 R--WDDTILSSALAANGWVFLLAYVSPEFWLLTKQRNPMDYPVEDAFCKPQLVKKSYGVE . ::: .. ::..:.::::: :. ::. .: .. .. :.. : ..:. :: XP_016 QPQWDDPVVCIALVTNAWVFLLLYIVPELCILYRSCR-QECPLQGNACPVTAYQHSFQVE 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE1 NRAYSQEEITQGFEETGDTLYAPYSTHFQLQNQPPQKEFSIPRAHAWPSPYKDYEVKKEG :. :.. XP_016 NQELSRDC 300 >>XP_006721114 (OMIM: 605948) PREDICTED: G-protein coupl (403 aa) initn: 586 init1: 404 opt: 652 Z-score: 742.6 bits: 146.1 E(85289): 1.3e-34 Smith-Waterman score: 670; 37.4% identity (66.4% similar) in 321 aa overlap (8-313:36-349) 10 20 30 pF1KE1 MATTVPDGCRNGLKSKYYRLCDKAEAWGIVLETVATA :: : .: ::: ::::.:.:: : XP_006 ERKMRAHQVLTFLLLFVITSVASENASTSRGCGLDLLPQYVSLCDLDAIWGIVVEAVAGA 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE1 GVVTSVAFMLTLPILVCKVQDSNRRKMLPTQFLFLLGVLGIFGLTFAFIIGLDGSTGPTR :.. .. .:: : . . ........ . .::::::.::.::::::::: : . .: XP_006 GALITLLLMLILLVRLPFIKEKEKKSPVGLHFLFLLGTLGLFGLTFAFIIQEDETICSVR 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE1 FFLFGILFSICFSCLLAHAVSLTKLVR-GRKPLSLLVILGLAVGFSLVQDVIAIEYIVLT ::.:.::..::::::..: . .::: : : . .. :::. . ::: .::.:..::: XP_006 RFLWGVLFALCFSCLLSQAWRVRRLVRHGTGPAGWQLV-GLALCLMLVQVIIAVEWLVLT 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE1 MNRTNVNVFSELSAPRRNEDFVLLLTYVLFLMALTFLMSSFTFCGSFTGWKRHGAHIYLT . : .. . . :::. : : . :...:. .. ::.::.: :: .:: . .: XP_006 VLRD-----TRPACAYEPMDFVMALIYDMVLLVVTLGLALFTLCGKFKRWKLNGAFLLIT 190 200 210 220 230 220 230 240 250 260 pF1KE1 MLLSIAIWVAWITLLMLPDFDRR----WDDTILSSALAANGWVFLLAYVSPEF---WLLT .::. :::::.:. .. . . :.: :. .:::.::::.. .. ::. : . XP_006 AFLSVLIWVAWMTMYLFGNVKLQQGDAWNDPTLAITLAASGWVFVIFHAIPEIHCTLLPA 240 250 260 270 280 290 270 280 290 300 310 320 pF1KE1 KQRNPMDY-----PV--EDAFCKPQLVKKSYGVENRAYSQEEITQGFEETGDTLYAPYST :.: .: : : :: . . ..: .::.:.:..: . ... .: XP_006 LQENTPNYFDTSQPRMRETAFEEDVQLPRAY-MENKAFSMDEHNAALRTAGFPNGSLGKR 300 310 320 330 340 350 330 340 350 pF1KE1 HFQLQNQPPQKEFSIPRAHAWPSPYKDYEVKKEGS XP_006 PSGSLGKRPSAPFRSNVYQPTEMAVVLNGGTIPTAPPSHTGRHLW 360 370 380 390 400 >>NP_057319 (OMIM: 605948) G-protein coupled receptor fa (403 aa) initn: 586 init1: 404 opt: 652 Z-score: 742.6 bits: 146.1 E(85289): 1.3e-34 Smith-Waterman score: 670; 37.4% identity (66.4% similar) in 321 aa overlap (8-313:36-349) 10 20 30 pF1KE1 MATTVPDGCRNGLKSKYYRLCDKAEAWGIVLETVATA :: : .: ::: ::::.:.:: : NP_057 ERKMRAHQVLTFLLLFVITSVASENASTSRGCGLDLLPQYVSLCDLDAIWGIVVEAVAGA 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE1 GVVTSVAFMLTLPILVCKVQDSNRRKMLPTQFLFLLGVLGIFGLTFAFIIGLDGSTGPTR :.. .. .:: : . . ........ . .::::::.::.::::::::: : . .: NP_057 GALITLLLMLILLVRLPFIKEKEKKSPVGLHFLFLLGTLGLFGLTFAFIIQEDETICSVR 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE1 FFLFGILFSICFSCLLAHAVSLTKLVR-GRKPLSLLVILGLAVGFSLVQDVIAIEYIVLT ::.:.::..::::::..: . .::: : : . .. :::. . ::: .::.:..::: NP_057 RFLWGVLFALCFSCLLSQAWRVRRLVRHGTGPAGWQLV-GLALCLMLVQVIIAVEWLVLT 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE1 MNRTNVNVFSELSAPRRNEDFVLLLTYVLFLMALTFLMSSFTFCGSFTGWKRHGAHIYLT . : .. . . :::. : : . :...:. .. ::.::.: :: .:: . .: NP_057 VLRD-----TRPACAYEPMDFVMALIYDMVLLVVTLGLALFTLCGKFKRWKLNGAFLLIT 190 200 210 220 230 220 230 240 250 260 pF1KE1 MLLSIAIWVAWITLLMLPDFDRR----WDDTILSSALAANGWVFLLAYVSPEF---WLLT .::. :::::.:. .. . . :.: :. .:::.::::.. .. ::. : . NP_057 AFLSVLIWVAWMTMYLFGNVKLQQGDAWNDPTLAITLAASGWVFVIFHAIPEIHCTLLPA 240 250 260 270 280 290 270 280 290 300 310 320 pF1KE1 KQRNPMDY-----PV--EDAFCKPQLVKKSYGVENRAYSQEEITQGFEETGDTLYAPYST :.: .: : : :: . . ..: .::.:.:..: . ... .: NP_057 LQENTPNYFDTSQPRMRETAFEEDVQLPRAY-MENKAFSMDEHNAALRTAGFPNGSLGKR 300 310 320 330 340 350 330 340 350 pF1KE1 HFQLQNQPPQKEFSIPRAHAWPSPYKDYEVKKEGS NP_057 PSGSLGKRPSAPFRSNVYQPTEMAVVLNGGTIPTAPPSHTGRHLW 360 370 380 390 400 >>XP_006721115 (OMIM: 605948) PREDICTED: G-protein coupl (403 aa) initn: 586 init1: 404 opt: 652 Z-score: 742.6 bits: 146.1 E(85289): 1.3e-34 Smith-Waterman score: 670; 37.4% identity (66.4% similar) in 321 aa overlap (8-313:36-349) 10 20 30 pF1KE1 MATTVPDGCRNGLKSKYYRLCDKAEAWGIVLETVATA :: : .: ::: ::::.:.:: : XP_006 ERKMRAHQVLTFLLLFVITSVASENASTSRGCGLDLLPQYVSLCDLDAIWGIVVEAVAGA 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE1 GVVTSVAFMLTLPILVCKVQDSNRRKMLPTQFLFLLGVLGIFGLTFAFIIGLDGSTGPTR :.. .. .:: : . . ........ . .::::::.::.::::::::: : . .: XP_006 GALITLLLMLILLVRLPFIKEKEKKSPVGLHFLFLLGTLGLFGLTFAFIIQEDETICSVR 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE1 FFLFGILFSICFSCLLAHAVSLTKLVR-GRKPLSLLVILGLAVGFSLVQDVIAIEYIVLT ::.:.::..::::::..: . .::: : : . .. :::. . ::: .::.:..::: XP_006 RFLWGVLFALCFSCLLSQAWRVRRLVRHGTGPAGWQLV-GLALCLMLVQVIIAVEWLVLT 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE1 MNRTNVNVFSELSAPRRNEDFVLLLTYVLFLMALTFLMSSFTFCGSFTGWKRHGAHIYLT . : .. . . :::. : : . :...:. .. ::.::.: :: .:: . .: XP_006 VLRD-----TRPACAYEPMDFVMALIYDMVLLVVTLGLALFTLCGKFKRWKLNGAFLLIT 190 200 210 220 230 220 230 240 250 260 pF1KE1 MLLSIAIWVAWITLLMLPDFDRR----WDDTILSSALAANGWVFLLAYVSPEF---WLLT .::. :::::.:. .. . . :.: :. .:::.::::.. .. ::. : . XP_006 AFLSVLIWVAWMTMYLFGNVKLQQGDAWNDPTLAITLAASGWVFVIFHAIPEIHCTLLPA 240 250 260 270 280 290 270 280 290 300 310 320 pF1KE1 KQRNPMDY-----PV--EDAFCKPQLVKKSYGVENRAYSQEEITQGFEETGDTLYAPYST :.: .: : : :: . . ..: .::.:.:..: . ... .: XP_006 LQENTPNYFDTSQPRMRETAFEEDVQLPRAY-MENKAFSMDEHNAALRTAGFPNGSLGKR 300 310 320 330 340 350 330 340 350 pF1KE1 HFQLQNQPPQKEFSIPRAHAWPSPYKDYEVKKEGS XP_006 PSGSLGKRPSAPFRSNVYQPTEMAVVLNGGTIPTAPPSHTGRHLW 360 370 380 390 400 >>NP_001291700 (OMIM: 605948) G-protein coupled receptor (534 aa) initn: 586 init1: 404 opt: 652 Z-score: 740.9 bits: 146.2 E(85289): 1.6e-34 Smith-Waterman score: 670; 37.4% identity (66.4% similar) in 321 aa overlap (8-313:167-480) 10 20 30 pF1KE1 MATTVPDGCRNGLKSKYYRLCDKAEAWGIVLETVATA :: : .: ::: ::::.:.:: : NP_001 ERKMRAHQVLTFLLLFVITSVASENASTSRGCGLDLLPQYVSLCDLDAIWGIVVEAVAGA 140 150 160 170 180 190 40 50 60 70 80 90 pF1KE1 GVVTSVAFMLTLPILVCKVQDSNRRKMLPTQFLFLLGVLGIFGLTFAFIIGLDGSTGPTR :.. .. .:: : . . ........ . .::::::.::.::::::::: : . .: NP_001 GALITLLLMLILLVRLPFIKEKEKKSPVGLHFLFLLGTLGLFGLTFAFIIQEDETICSVR 200 210 220 230 240 250 100 110 120 130 140 150 pF1KE1 FFLFGILFSICFSCLLAHAVSLTKLVR-GRKPLSLLVILGLAVGFSLVQDVIAIEYIVLT ::.:.::..::::::..: . .::: : : . .. :::. . ::: .::.:..::: NP_001 RFLWGVLFALCFSCLLSQAWRVRRLVRHGTGPAGWQLV-GLALCLMLVQVIIAVEWLVLT 260 270 280 290 300 310 160 170 180 190 200 210 pF1KE1 MNRTNVNVFSELSAPRRNEDFVLLLTYVLFLMALTFLMSSFTFCGSFTGWKRHGAHIYLT . : .. . . :::. : : . :...:. .. ::.::.: :: .:: . .: NP_001 VLRD-----TRPACAYEPMDFVMALIYDMVLLVVTLGLALFTLCGKFKRWKLNGAFLLIT 320 330 340 350 360 370 220 230 240 250 260 pF1KE1 MLLSIAIWVAWITLLMLPDFDRR----WDDTILSSALAANGWVFLLAYVSPEF---WLLT .::. :::::.:. .. . . :.: :. .:::.::::.. .. ::. : . NP_001 AFLSVLIWVAWMTMYLFGNVKLQQGDAWNDPTLAITLAASGWVFVIFHAIPEIHCTLLPA 380 390 400 410 420 430 270 280 290 300 310 320 pF1KE1 KQRNPMDY-----PV--EDAFCKPQLVKKSYGVENRAYSQEEITQGFEETGDTLYAPYST :.: .: : : :: . . ..: .::.:.:..: . ... .: NP_001 LQENTPNYFDTSQPRMRETAFEEDVQLPRAY-MENKAFSMDEHNAALRTAGFPNGSLGKR 440 450 460 470 480 330 340 350 pF1KE1 HFQLQNQPPQKEFSIPRAHAWPSPYKDYEVKKEGS NP_001 PSGSLGKRPSAPFRSNVYQPTEMAVVLNGGTIPTAPPSHTGRHLW 490 500 510 520 530 >>NP_061123 (OMIM: 605949) G-protein coupled receptor fa (453 aa) initn: 752 init1: 456 opt: 478 Z-score: 545.6 bits: 109.8 E(85289): 1.2e-23 Smith-Waterman score: 718; 38.5% identity (64.7% similar) in 374 aa overlap (5-342:39-408) 10 20 30 pF1KE1 MATTVPDGCRNGLKSKYYRLCDKAEAWGIVLETV :: :: .::. :: :::.. :::::::.: NP_061 LGARMAIHKALVMCLGLPLFLFPGAWAQGHVPPGCSQGLNPLYYNLCDRSGAWGIVLEAV 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE1 ATAGVVTSVAFMLTLPILVCK---VQDSNRRKMLPTQFLFLLGVLGIFGLTFAFIIGLDG : ::.::. :.::. ::: . :::...:..: :: .::::.::.: :.:: .. : NP_061 AGAGIVTT--FVLTI-ILVASLPFVQDTKKRSLLGTQVFFLLGTLGLFCLVFACVVKPDF 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE1 STGPTRFFLFGILFSICFSCLLAHAVSLTKLVRGRKPLSLLVILGLAVGFSLVQDVIAIE :: .: ::::.::.:::::: ::. .:. :.: . ::. .:. ..::. .: : NP_061 STCASRRFLFGVLFAICFSCLAAHVFALNFLARKNHGPRGWVIFTVALLLTLVEVIINTE 130 140 150 160 170 180 160 170 180 190 200 pF1KE1 YIVLTMNRT--------NVNVFSELSAPRR--NEDFVLLLTYVLFLMALTFLMSSFTFCG ....:. : : .. ...: : :::. : ::..:. .:: . ..:: NP_061 WLIITLVRGSGEGGPQGNSSAGWAVASPCAIANMDFVMALIYVMLLLLGAFLGAWPALCG 190 200 210 220 230 240 210 220 230 240 250 pF1KE1 SFTGWKRHGAHIYLTMLLSIAIWVAWITLLMLPDFDRR---WDDTILSSALAANGWVFLL . :..::. . :: :.::::.::.. . .. ::: :. :::::.:.:.: NP_061 RYKRWRKHGVFVLLTTATSVAIWVVWIVMYTYGNKQHNSPTWDDPTLAIALAANAWAFVL 250 260 270 280 290 300 260 270 280 290 300 pF1KE1 AYVSPEFWLLTK----QRNPMD-YPVE----DAFCKPQLVKKSYGVENRAYSQEE----- :: :: .:: : : ::.. ... : : .:. :::.:.:..: NP_061 FYVIPEVSQVTKSSPEQSYQGDMYPTRGVGYETILKEQK-GQSMFVENKAFSMDEPVAAK 310 320 330 340 350 360 310 320 330 340 350 pF1KE1 --ITQGFEETGDTLYAPYS-THFQLQNQPPQK---EFSIPRAHAWPSPYKDYEVKKEGS .. .:. : . :. :.. :... :.. .. .::: : NP_061 RPVSPYSGYNGQLLTSVYQPTEMALMHKVPSEGAYDIILPRATANSQVMGSANSTLRAED 370 380 390 400 410 420 NP_061 MYSAQSHQAATPPKDGKNSQVFRNPYVWD 430 440 450 357 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 14:55:59 2016 done: Sun Nov 6 14:56:00 2016 Total Scan time: 6.550 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]