Result of FASTA (omim) for
pF1KE1246
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1246, 482 aa
1>>>pF1KE1246 482 - 482 aa - 482 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.6043+/-0.000374; mu= 16.0641+/- 0.023
mean_var=67.4981+/-13.781, 0's: 0 Z-trim(113.4): 178 B-trim: 327 in 1/49
Lambda= 0.156109
statistics sampled from 22602 (22780) to 22602 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.636), E-opt: 0.2 (0.267), width: 16
Scan time: 9.410
The best scores are: opt bits E(85289)
NP_001034612 (OMIM: 100690,253290,601462,608930) a ( 482) 3237 738.2 1.2e-212
XP_016858745 (OMIM: 100690,253290,601462,608930) P ( 489) 3144 717.2 2.5e-206
NP_000070 (OMIM: 100690,253290,601462,608930) acet ( 457) 2578 589.7 5.5e-168
XP_016858746 (OMIM: 100690,253290,601462,608930) P ( 464) 2578 589.8 5.6e-168
XP_006720445 (OMIM: 118503,612052) PREDICTED: neur ( 438) 1164 271.3 3.9e-72
NP_001160166 (OMIM: 118503,612052) neuronal acetyl ( 489) 1164 271.3 4.3e-72
NP_000734 (OMIM: 118503,612052) neuronal acetylcho ( 505) 1164 271.3 4.4e-72
NP_000735 (OMIM: 118504,188890,600513) neuronal ac ( 627) 1165 271.6 4.6e-72
XP_016883113 (OMIM: 118504,188890,600513) PREDICTE ( 546) 1163 271.1 5.5e-72
NP_001186208 (OMIM: 606888) neuronal acetylcholine ( 479) 1127 263.0 1.4e-69
NP_004189 (OMIM: 606888) neuronal acetylcholine re ( 494) 1117 260.7 6.7e-69
XP_006716345 (OMIM: 118502,610353) PREDICTED: neur ( 529) 1113 259.8 1.3e-68
NP_000733 (OMIM: 118502,610353) neuronal acetylcho ( 529) 1113 259.8 1.3e-68
XP_011542690 (OMIM: 118502,610353) PREDICTED: neur ( 529) 1113 259.8 1.3e-68
NP_001269384 (OMIM: 118502,610353) neuronal acetyl ( 514) 1110 259.2 2.1e-68
NP_000740 (OMIM: 118508) neuronal acetylcholine re ( 458) 1106 258.2 3.5e-68
NP_000736 (OMIM: 118505,612052) neuronal acetylcho ( 468) 1032 241.6 3.7e-63
NP_000739 (OMIM: 118507,605375) neuronal acetylcho ( 502) 976 229.0 2.4e-59
XP_011526826 (OMIM: 118504,188890,600513) PREDICTE ( 556) 975 228.8 3.1e-59
XP_011519492 (OMIM: 118509) PREDICTED: neuronal ac ( 424) 964 226.2 1.4e-58
XP_011519493 (OMIM: 118509) PREDICTED: neuronal ac ( 424) 964 226.2 1.4e-58
XP_016877378 (OMIM: 118509) PREDICTED: neuronal ac ( 449) 964 226.2 1.4e-58
XP_016877377 (OMIM: 118509) PREDICTED: neuronal ac ( 462) 964 226.2 1.5e-58
XP_016877376 (OMIM: 118509) PREDICTED: neuronal ac ( 463) 964 226.3 1.5e-58
XP_016877375 (OMIM: 118509) PREDICTED: neuronal ac ( 468) 964 226.3 1.5e-58
XP_016877374 (OMIM: 118509) PREDICTED: neuronal ac ( 468) 964 226.3 1.5e-58
XP_011519488 (OMIM: 118509) PREDICTED: neuronal ac ( 495) 964 226.3 1.6e-58
XP_011519489 (OMIM: 118509) PREDICTED: neuronal ac ( 495) 964 226.3 1.6e-58
NP_000741 (OMIM: 118509) neuronal acetylcholine re ( 498) 964 226.3 1.6e-58
XP_011542692 (OMIM: 118508) PREDICTED: neuronal ac ( 329) 886 208.6 2.1e-53
XP_016868492 (OMIM: 118502,610353) PREDICTED: neur ( 370) 882 207.7 4.4e-53
XP_005273454 (OMIM: 118502,610353) PREDICTED: neur ( 370) 882 207.7 4.4e-53
NP_065135 (OMIM: 606372) neuronal acetylcholine re ( 450) 871 205.3 2.9e-52
XP_011519478 (OMIM: 118511,612001) PREDICTED: neur ( 486) 845 199.5 1.8e-50
NP_000737 (OMIM: 118511,612001) neuronal acetylcho ( 502) 845 199.5 1.9e-50
NP_001177384 (OMIM: 118511,612001) neuronal acetyl ( 531) 845 199.5 2e-50
NP_060051 (OMIM: 605116) neuronal acetylcholine re ( 479) 835 197.2 8.5e-50
XP_016883114 (OMIM: 118504,188890,600513) PREDICTE ( 451) 757 179.6 1.6e-44
NP_001243502 (OMIM: 118504,188890,600513) neuronal ( 451) 757 179.6 1.6e-44
XP_011542691 (OMIM: 118502,610353) PREDICTED: neur ( 331) 719 171.0 4.5e-42
XP_016868493 (OMIM: 118502,610353) PREDICTED: neur ( 331) 719 171.0 4.5e-42
XP_011519480 (OMIM: 118511,612001) PREDICTED: neur ( 380) 698 166.3 1.4e-40
XP_011519479 (OMIM: 118511,612001) PREDICTED: neur ( 401) 697 166.1 1.7e-40
XP_016877372 (OMIM: 118511,612001) PREDICTED: neur ( 440) 693 165.2 3.4e-40
XP_016877371 (OMIM: 118511,612001) PREDICTED: neur ( 441) 693 165.2 3.4e-40
NP_647536 (OMIM: 609756) CHRNA7-FAM7A fusion prote ( 412) 692 165.0 3.7e-40
XP_011520455 (OMIM: 609756) PREDICTED: CHRNA7-FAM7 ( 412) 692 165.0 3.7e-40
XP_016855669 (OMIM: 118507,605375) PREDICTED: neur ( 332) 612 146.9 8.1e-35
XP_011519494 (OMIM: 118509) PREDICTED: neuronal ac ( 316) 580 139.7 1.1e-32
NP_001155244 (OMIM: 182139) 5-hydroxytryptamine re ( 463) 559 135.0 4.3e-31
>>NP_001034612 (OMIM: 100690,253290,601462,608930) acety (482 aa)
initn: 3237 init1: 3237 opt: 3237 Z-score: 3938.6 bits: 738.2 E(85289): 1.2e-212
Smith-Waterman score: 3237; 100.0% identity (100.0% similar) in 482 aa overlap (1-482:1-482)
10 20 30 40 50 60
pF1KE1 MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 INVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 INVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 KKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 PFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 TPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 FLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 FIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 IEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQ
430 440 450 460 470 480
pF1KE1 QG
::
NP_001 QG
>>XP_016858745 (OMIM: 100690,253290,601462,608930) PREDI (489 aa)
initn: 3144 init1: 3144 opt: 3144 Z-score: 3825.3 bits: 717.2 E(85289): 2.5e-206
Smith-Waterman score: 3144; 98.9% identity (99.4% similar) in 476 aa overlap (7-482:14-489)
10 20 30 40 50
pF1KE1 MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTV
.:. : ::::::::::::::::::::::::::::::::::::::::
XP_016 MFMCLEGGEKNLTVLVSSAVSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 GLQLIQLINVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLQLIQLINVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWN
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE1 PDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYC
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE1 EIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSV
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE1 TYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSIS
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE1 VLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVM
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE1 PNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIK
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE1 HPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAG
430 440 450 460 470 480
480
pF1KE1 RLIELNQQG
:::::::::
XP_016 RLIELNQQG
>>NP_000070 (OMIM: 100690,253290,601462,608930) acetylch (457 aa)
initn: 2567 init1: 2567 opt: 2578 Z-score: 3136.8 bits: 589.7 E(85289): 5.5e-168
Smith-Waterman score: 3000; 94.8% identity (94.8% similar) in 482 aa overlap (1-482:1-457)
10 20 30 40 50 60
pF1KE1 MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 INVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGV
:::::::::::::::::: :::::::::::::::::
NP_000 INVDEVNQIVTTNVRLKQ-------------------------QWVDYNLKWNPDDYGGV
70 80 90
130 140 150 160 170 180
pF1KE1 KKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 KKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHF
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE1 PFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 PFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPD
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE1 TPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTV
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE1 FLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 FLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKV
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE1 FIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 FIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSA
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE1 IEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQ
400 410 420 430 440 450
pF1KE1 QG
::
NP_000 QG
>>XP_016858746 (OMIM: 100690,253290,601462,608930) PREDI (464 aa)
initn: 2567 init1: 2567 opt: 2578 Z-score: 3136.7 bits: 589.8 E(85289): 5.6e-168
Smith-Waterman score: 2907; 93.7% identity (94.1% similar) in 476 aa overlap (7-482:14-464)
10 20 30 40 50
pF1KE1 MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTV
.:. : ::::::::::::::::::::::::::::::::::::::::
XP_016 MFMCLEGGEKNLTVLVSSAVSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 GLQLIQLINVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWN
::::::::::::::::::::::::: ::::::::::
XP_016 GLQLIQLINVDEVNQIVTTNVRLKQ-------------------------QWVDYNLKWN
70 80 90
120 130 140 150 160 170
pF1KE1 PDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYC
100 110 120 130 140 150
180 190 200 210 220 230
pF1KE1 EIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSV
160 170 180 190 200 210
240 250 260 270 280 290
pF1KE1 TYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSIS
220 230 240 250 260 270
300 310 320 330 340 350
pF1KE1 VLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVM
280 290 300 310 320 330
360 370 380 390 400 410
pF1KE1 PNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIK
340 350 360 370 380 390
420 430 440 450 460 470
pF1KE1 HPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAG
400 410 420 430 440 450
480
pF1KE1 RLIELNQQG
:::::::::
XP_016 RLIELNQQG
460
>>XP_006720445 (OMIM: 118503,612052) PREDICTED: neuronal (438 aa)
initn: 1431 init1: 583 opt: 1164 Z-score: 1416.0 bits: 271.3 E(85289): 3.9e-72
Smith-Waterman score: 1322; 47.0% identity (70.3% similar) in 455 aa overlap (59-471:3-428)
30 40 50 60 70 80
pF1KE1 AKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQGDMVDLPRPS
::..:::::::. ::. :::
XP_006 MSQLVKVDEVNQIMETNLWLKQ----------
10 20
90 100 110 120 130 140
pF1KE1 CVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIV
: ::.:::::.::::.. ...:..:::.::.:::::: ::: .
XP_006 ---------------IWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVD
30 40 50 60
150 160 170 180 190 200
pF1KE1 KFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESD
::.::.:::..:: ::::::: :.: ::.:::: :::.::.:.:.:: . . . ..
XP_006 DKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGS
70 80 90 100 110 120
210 220 230 240 250 260
pF1KE1 QPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCL
. .:... :::::.: .. :.::.. :.:: . : :::: . ..::::.. .:.:::::
XP_006 SMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEI-YPDITYSLYIRRLPLFYTINLIIPCL
130 140 150 160 170 180
270 280 290 300 310 320
pF1KE1 LFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMV
:.:::: ::::::.: :::.:: ::::::::::::::.: ::::: ..::::.:.::::.
XP_006 LISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMI
190 200 210 220 230 240
330 340 350 360 370 380
pF1KE1 FVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSRE----KQDK
:: ::.:::.:.:.:.:.:.::.::.::. ::.. .: .:: : ::. . .. .
XP_006 FVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMF---MTRPTSNEGNAQKPR
250 260 270 280 290 300
390 400 410
pF1KE1 KIFTEDI-DISDIS---------GKPGPPPM-GF-HSPLIK-------------------
.. .. ... .: : : : :. : ::
XP_006 PLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDA
310 320 330 340 350 360
420 430 440 450 460
pF1KE1 -------HPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIG
::.: ::...:::::.::...:... .:::::::.:.:.: :: ::::.:
XP_006 VLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILG
370 380 390 400 410 420
470 480
pF1KE1 TLAVFAGRLIELNQQG
: ..:
XP_006 TAGLFLQPLMAREDA
430
>>NP_001160166 (OMIM: 118503,612052) neuronal acetylchol (489 aa)
initn: 1394 init1: 583 opt: 1164 Z-score: 1415.3 bits: 271.3 E(85289): 4.3e-72
Smith-Waterman score: 1290; 44.7% identity (68.3% similar) in 479 aa overlap (1-437:12-461)
10 20 30 40
pF1KE1 MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVV
. : ::::. : .. .:: : :: .::.::. ..::: . . :
NP_001 MGSGPLSLPLALSPPRLLLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPV
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE1 EVTVGLQLIQLINVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYN
. ... ::..:::::::. ::. ::: : ::.
NP_001 IIHFEVSMSQLVKVDEVNQIMETNLWLKQ-------------------------IWNDYK
70 80 90
110 120 130 140 150 160
pF1KE1 LKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIF
:::::.::::.. ...:..:::.::.:::::: ::: . ::.::.:::..:: :::::
NP_001 LKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIF
100 110 120 130 140 150
170 180 190 200 210 220
pF1KE1 KSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGW
:: :.: ::.:::: :::.::.:.:.:: . . . ... .:... :::::.: .. :.
NP_001 KSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGY
160 170 180 190 200 210
230 240 250 260 270 280
pF1KE1 KHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMT
::.. :.:: . : :::: . ..::::.. .:.::::::.:::: ::::::.: :::.:
NP_001 KHDIKYNCCEEI-YPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVT
220 230 240 250 260 270
290 300 310 320 330 340
pF1KE1 LSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPS
: ::::::::::::::.: ::::: ..::::.:.::::.:: ::.:::.:.:.:.:.:.
NP_001 LCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPT
280 290 300 310 320 330
350 360 370 380 390
pF1KE1 THVMPNWVRKVFIDTIPNIMFFSTMKRPSRE----KQDKKIFTEDI-DISDIS-------
::.::.::. ::.. .: .:: : ::. . .. . .. .. ... .:
NP_001 THTMPSWVKTVFLNLLPRVMF---MTRPTSNEGNAQKPRPLYGAELSNLNCFSRAESKGC
340 350 360 370 380 390
400 410 420
pF1KE1 --GKPGPPPM-GF-HSPLIK--------------------------HPEVKSAIEGIKYI
: : : :. : :: ::.: ::...:::
NP_001 KEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYI
400 410 420 430 440 450
430 440 450 460 470 480
pF1KE1 AETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQQG
::.::...:.
NP_001 AENMKAQNEAKEEQKAQEIQQLKRKEKSTETSDQEPGL
460 470 480
>>NP_000734 (OMIM: 118503,612052) neuronal acetylcholine (505 aa)
initn: 1523 init1: 583 opt: 1164 Z-score: 1415.1 bits: 271.3 E(85289): 4.4e-72
Smith-Waterman score: 1419; 45.4% identity (69.2% similar) in 513 aa overlap (1-471:12-495)
10 20 30 40
pF1KE1 MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVV
. : ::::. : .. .:: : :: .::.::. ..::: . . :
NP_000 MGSGPLSLPLALSPPRLLLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPV
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE1 EVTVGLQLIQLINVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYN
. ... ::..:::::::. ::. ::: : ::.
NP_000 IIHFEVSMSQLVKVDEVNQIMETNLWLKQ-------------------------IWNDYK
70 80 90
110 120 130 140 150 160
pF1KE1 LKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIF
:::::.::::.. ...:..:::.::.:::::: ::: . ::.::.:::..:: :::::
NP_000 LKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIF
100 110 120 130 140 150
170 180 190 200 210 220
pF1KE1 KSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGW
:: :.: ::.:::: :::.::.:.:.:: . . . ... .:... :::::.: .. :.
NP_000 KSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGY
160 170 180 190 200 210
230 240 250 260 270 280
pF1KE1 KHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMT
::.. :.:: . : :::: . ..::::.. .:.::::::.:::: ::::::.: :::.:
NP_000 KHDIKYNCCEEI-YPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVT
220 230 240 250 260 270
290 300 310 320 330 340
pF1KE1 LSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPS
: ::::::::::::::.: ::::: ..::::.:.::::.:: ::.:::.:.:.:.:.:.
NP_000 LCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPT
280 290 300 310 320 330
350 360 370 380 390
pF1KE1 THVMPNWVRKVFIDTIPNIMFFSTMKRPSRE----KQDKKIFTEDI-DISDIS-------
::.::.::. ::.. .: .:: : ::. . .. . .. .. ... .:
NP_000 THTMPSWVKTVFLNLLPRVMF---MTRPTSNEGNAQKPRPLYGAELSNLNCFSRAESKGC
340 350 360 370 380 390
400 410 420
pF1KE1 --GKPGPPPM-GF-HSPLIK--------------------------HPEVKSAIEGIKYI
: : : :. : :: ::.: ::...:::
NP_000 KEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYI
400 410 420 430 440 450
430 440 450 460 470 480
pF1KE1 AETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQQG
::.::...:... .:::::::.:.:.: :: ::::.:: ..:
NP_000 AENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFLQPLMAREDA
460 470 480 490 500
>>NP_000735 (OMIM: 118504,188890,600513) neuronal acetyl (627 aa)
initn: 1283 init1: 587 opt: 1165 Z-score: 1414.8 bits: 271.6 E(85289): 4.6e-72
Smith-Waterman score: 1283; 50.4% identity (71.6% similar) in 409 aa overlap (5-406:14-390)
10 20 30 40
pF1KE1 MEPWPLLLLFSLCSAGLVLGSEH-------ETRLVAKLFKDYSSVVRPVED
:::::. ..::. .: : : ::. :::. :.. ::: .
NP_000 MELGGPGAPRLLPPLLLLL---GTGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVAN
10 20 30 40 50
50 60 70 80 90 100
pF1KE1 HRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQ
.:: : ::.. :::.::: ::..:::: .:: .
NP_000 ISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQ-------------------------E
60 70 80 90
110 120 130 140 150 160
pF1KE1 WVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWT
: ::.:.:.: :: .: .:.:::: :::::.:::::::::::....::. : . :.. ::
NP_000 WHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWT
100 110 120 130 140 150
170 180 190 200 210 220
pF1KE1 PPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIK
::::.:: : : :: ::::.:::.::.:.:::: . . . .. : .: :::::::
NP_000 PPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIV
160 170 180 190 200 210
230 240 250 260 270 280
pF1KE1 ESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDS
.. : .. : :: . : :::: ::..::::.. .:.::::::.: :: ::::::..
NP_000 DAVGTYNTRKYECCAEI-YPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSEC
220 230 240 250 260 270
290 300 310 320 330 340
pF1KE1 GEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTH
:::.:: ::::::::::::.:.:.::::: ..::::.:.::::.:: ::.:::.:.:.:
NP_000 GEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVH
280 290 300 310 320 330
350 360 370 380 390 400
pF1KE1 HRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPP
:::: ::.::.:::.::.: .: ... ::::: :.. . . :.. . . : :
NP_000 HRSPRTHTMPTWVRRVFLDIVPRLLL---MKRPSVVKDNCRRLIESMHKMASAPRFWPEP
340 350 360 370 380
410 420 430 440 450 460
pF1KE1 MGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCI
:
NP_000 EGEPPATSGTQSLHPPSPSFCVPLDVPAEPGPSCKSPSDQLPPQQPLEAEKASPHPSPGP
390 400 410 420 430 440
>--
initn: 221 init1: 173 opt: 211 Z-score: 253.6 bits: 56.7 E(85289): 2.2e-07
Smith-Waterman score: 211; 42.9% identity (77.1% similar) in 70 aa overlap (402-471:554-618)
380 390 400 410 420 430
pF1KE1 STMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSAIEGIKYIAETM
::: : :: : . :.::..:::. .
NP_000 DQPSPCKCTCKKEPSSVSPSATVKTRSTKAPPP---HLPL--SPALTRAVEGVQYIADHL
530 540 550 560 570
440 450 460 470 480
pF1KE1 KSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQQG
:... . .. .:::::::.:.:.: .:..::..::...:
NP_000 KAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI
580 590 600 610 620
>>XP_016883113 (OMIM: 118504,188890,600513) PREDICTED: n (546 aa)
initn: 1283 init1: 587 opt: 1163 Z-score: 1413.3 bits: 271.1 E(85289): 5.5e-72
Smith-Waterman score: 1163; 55.3% identity (78.6% similar) in 304 aa overlap (103-406:10-309)
80 90 100 110 120 130
pF1KE1 NVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHIPSEKIWR
..: ::.:.:.: :: .: .:.:::: :::
XP_016 MMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWR
10 20 30
140 150 160 170 180 190
pF1KE1 PDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLG
::.:::::::::::....::. : . :.. ::::::.:: : : :: ::::.:::.::.:
XP_016 PDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFG
40 50 60 70 80 90
200 210 220 230 240 250
pF1KE1 TWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVM
.:::: . . . .. : .: ::::::: .. : .. : :: . : :::: ::.
XP_016 SWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEI-YPDITYAFVI
100 110 120 130 140 150
260 270 280 290 300 310
pF1KE1 QRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPST
.::::.. .:.::::::.: :: ::::::.. :::.:: ::::::::::::.:.:.::::
XP_016 RRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPST
160 170 180 190 200 210
320 330 340 350 360 370
pF1KE1 SSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFS
: ..::::.:.::::.:: ::.:::.:.:.::::: ::.::.:::.::.: .: ...
XP_016 SLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLL--
220 230 240 250 260 270
380 390 400 410 420 430
pF1KE1 TMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSAIEGIKYIAETMK
::::: :.. . . :.. . . : : :
XP_016 -MKRPSVVKDNCRRLIESMHKMASAPRFWPEPEGEPPATSGTQSLHPPSPSFCVPLDVPA
280 290 300 310 320 330
440 450 460 470 480
pF1KE1 SDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQQG
XP_016 EPGPSCKSPSDQLPPQQPLEAEKASPHPSPGPCRPPHGTQAPGLAKARSLSVQHMSSPGE
340 350 360 370 380 390
>--
initn: 221 init1: 173 opt: 211 Z-score: 254.6 bits: 56.7 E(85289): 1.9e-07
Smith-Waterman score: 211; 42.9% identity (77.1% similar) in 70 aa overlap (402-471:473-537)
380 390 400 410 420 430
pF1KE1 STMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSAIEGIKYIAETM
::: : :: : . :.::..:::. .
XP_016 DQPSPCKCTCKKEPSSVSPSATVKTRSTKAPPP---HLPL--SPALTRAVEGVQYIADHL
450 460 470 480 490
440 450 460 470 480
pF1KE1 KSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQQG
:... . .. .:::::::.:.:.: .:..::..::...:
XP_016 KAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI
500 510 520 530 540
>>NP_001186208 (OMIM: 606888) neuronal acetylcholine rec (479 aa)
initn: 1369 init1: 565 opt: 1127 Z-score: 1370.4 bits: 263.0 E(85289): 1.4e-69
Smith-Waterman score: 1267; 45.3% identity (74.3% similar) in 413 aa overlap (87-471:58-468)
60 70 80 90 100 110
pF1KE1 LIQLINVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDD
: : . : . ..: : : ::.:.:.: .
NP_001 CVGCATEERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAI-TQLANVIWNDYKLRWDPME
30 40 50 60 70 80
120 130 140 150 160 170
pF1KE1 YGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEII
: :.. ...:..:::.::.:::::: ::: . ::.::.:.: ::::::::::: : .
NP_001 YDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNGMITWTPPAIFKSSCPMD
90 100 110 120 130 140
180 190 200 210 220 230
pF1KE1 VTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYS
.: ::::.::::.:.:.:::: . . . ... :...: :..:: : .. :.::.. :.
NP_001 ITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENSEWEIIDASGYKHDIKYN
150 160 170 180 190 200
240 250 260 270 280 290
pF1KE1 CCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLL
:: . : :::: : ..:::... .:.:::::..:::: ::::::.: :::.:: :::::
NP_001 CCEEI-YTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLL
210 220 230 240 250 260
300 310 320 330 340 350
pF1KE1 SLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNW
:::::::::.: ::::: .:::.:.:.::::.:: ::..::.:.: :.:.:.::.:: :
NP_001 SLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPTTHTMPRW
270 280 290 300 310 320
360 370 380
pF1KE1 VRKVFIDTIPNIMFF-----------------STMKRPSREK--------QDKKIFT--E
:. ::. .:..... . .::.. : . :. : .
NP_001 VKTVFLKLLPQVLLMRWPLDKTRGTGSDAVPRGLARRPAKGKLASHGEPRHLKECFHCHK
330 340 350 360 370 380
390 400 410 420 430 440
pF1KE1 DIDISDISGKPGPPPMGFHSPLIKH-PEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVA
. ... . . . :. . .: :::...:.....:::.::: .:.... .:::::
NP_001 SNELATSKRRLSHQPLQWVVENSEHSPEVEDVINSVQFIAENMKSHNETKEVEDDWKYVA
390 400 410 420 430 440
450 460 470 480
pF1KE1 MVMDHILLGVFMLVCIIGTLAVFAGRLIELNQQG
::.:...: ::..::..:: ..:
NP_001 MVVDRVFLWVFIIVCVFGTAGLFLQPLLGNTGKS
450 460 470
482 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 18:11:49 2016 done: Sun Nov 6 18:11:50 2016
Total Scan time: 9.410 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]