FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1303, 416 aa 1>>>pF1KE1303 416 - 416 aa - 416 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.8307+/-0.000738; mu= 15.1030+/- 0.044 mean_var=77.1391+/-15.305, 0's: 0 Z-trim(109.8): 45 B-trim: 0 in 0/51 Lambda= 0.146028 statistics sampled from 11132 (11175) to 11132 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.716), E-opt: 0.2 (0.343), width: 16 Scan time: 3.180 The best scores are: opt bits E(32554) CCDS158.1 CASP9 gene_id:842|Hs108|chr1 ( 416) 2819 603.1 1.6e-172 CCDS159.2 CASP9 gene_id:842|Hs108|chr1 ( 333) 2267 486.7 1.4e-137 CCDS59995.1 CASP9 gene_id:842|Hs108|chr1 ( 266) 918 202.5 4e-52 CCDS5879.1 CASP2 gene_id:835|Hs108|chr7 ( 452) 437 101.3 2e-21 CCDS3836.1 CASP3 gene_id:836|Hs108|chr4 ( 277) 392 91.7 9.4e-19 CCDS2343.1 CASP8 gene_id:841|Hs108|chr2 ( 464) 391 91.6 1.7e-18 CCDS2342.1 CASP8 gene_id:841|Hs108|chr2 ( 479) 391 91.6 1.7e-18 CCDS42799.1 CASP8 gene_id:841|Hs108|chr2 ( 496) 391 91.6 1.8e-18 CCDS42798.1 CASP8 gene_id:841|Hs108|chr2 ( 538) 391 91.6 1.9e-18 CCDS58096.1 CASP7 gene_id:840|Hs108|chr10 ( 278) 320 76.5 3.5e-14 CCDS7581.1 CASP7 gene_id:840|Hs108|chr10 ( 303) 320 76.5 3.8e-14 CCDS73200.1 CASP7 gene_id:840|Hs108|chr10 ( 388) 321 76.8 4e-14 CCDS7580.1 CASP7 gene_id:840|Hs108|chr10 ( 336) 320 76.6 4.1e-14 CCDS3684.1 CASP6 gene_id:839|Hs108|chr4 ( 293) 286 69.4 5.2e-12 CCDS56160.1 CASP10 gene_id:843|Hs108|chr2 ( 478) 270 66.1 8.2e-11 CCDS2339.1 CASP10 gene_id:843|Hs108|chr2 ( 479) 270 66.1 8.2e-11 >>CCDS158.1 CASP9 gene_id:842|Hs108|chr1 (416 aa) initn: 2819 init1: 2819 opt: 2819 Z-score: 3210.8 bits: 603.1 E(32554): 1.6e-172 Smith-Waterman score: 2819; 100.0% identity (100.0% similar) in 416 aa overlap (1-416:1-416) 10 20 30 40 50 60 pF1KE1 MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS15 MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS15 DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 LRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS15 LRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 TGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS15 TGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 ASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS15 ASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVAS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 TSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS15 TSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSG 310 320 330 340 350 360 370 380 390 400 410 pF1KE1 SWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS15 SWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS 370 380 390 400 410 >>CCDS159.2 CASP9 gene_id:842|Hs108|chr1 (333 aa) initn: 2267 init1: 2267 opt: 2267 Z-score: 2583.7 bits: 486.7 E(32554): 1.4e-137 Smith-Waterman score: 2267; 100.0% identity (100.0% similar) in 333 aa overlap (84-416:1-333) 60 70 80 90 100 110 pF1KE1 QARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRP :::::::::::::::::::::::::::::: CCDS15 MLASFLRTNRQAAKLSKPTLENLTPVVLRP 10 20 30 120 130 140 150 160 170 pF1KE1 EIRKPEVLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS15 EIRKPEVLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCR 40 50 60 70 80 90 180 190 200 210 220 230 pF1KE1 ESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS15 ESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVV 100 110 120 130 140 150 240 250 260 270 280 290 pF1KE1 ILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS15 ILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKD 160 170 180 190 200 210 300 310 320 330 340 350 pF1KE1 HGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS15 HGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVS 220 230 240 250 260 270 360 370 380 390 400 410 pF1KE1 WRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS15 WRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFF 280 290 300 310 320 330 pF1KE1 KTS ::: CCDS15 KTS >>CCDS59995.1 CASP9 gene_id:842|Hs108|chr1 (266 aa) initn: 1774 init1: 918 opt: 918 Z-score: 1049.3 bits: 202.5 E(32554): 4e-52 Smith-Waterman score: 1478; 63.9% identity (63.9% similar) in 416 aa overlap (1-416:1-266) 10 20 30 40 50 60 pF1KE1 MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 LRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTR ::::::::::::::::::: CCDS59 LRPETPRPVDIGSGGFGDV----------------------------------------- 130 190 200 210 220 230 240 pF1KE1 TGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQ CCDS59 ------------------------------------------------------------ 250 260 270 280 290 300 pF1KE1 ASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVAS ::::::::::: CCDS59 -------------------------------------------------EQKDHGFEVAS 140 150 310 320 330 340 350 360 pF1KE1 TSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 TSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSG 160 170 180 190 200 210 370 380 390 400 410 pF1KE1 SWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 SWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS 220 230 240 250 260 >>CCDS5879.1 CASP2 gene_id:835|Hs108|chr7 (452 aa) initn: 308 init1: 200 opt: 437 Z-score: 498.1 bits: 101.3 E(32554): 2e-21 Smith-Waterman score: 548; 31.3% identity (59.0% similar) in 422 aa overlap (1-410:32-430) 10 20 30 pF1KE1 MDEADRRLLRRCRLRLVEELQVDQLWDALL : .. :.. :. :...: ...: . :: CCDS58 AAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSELLEHLL 10 20 30 40 50 60 40 50 60 70 80 pF1KE1 SRELFRPHMIEDIQ-RAGSGSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFL .... .: : :: ..:: : : .:. : :: ::. : :..: : : ..: CCDS58 EKDIITLEMRELIQAKVGSFS---QNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDML 70 80 90 100 110 90 100 110 120 130 140 pF1KE1 RTNRQAAKLSKPTLE---NLT---PVVLR-PEIRKPEVLRPETPRPVDIGSGGFG-DVGA :. .. . : : .:. :: : .: .. . . .: .: .: CCDS58 LTTLSGLQHVLPPLSCDYDLSLPFPVCESCPLYKKLRLSTDTVEHSLDNKDGPVCLQVKP 120 130 140 150 160 170 150 160 170 180 190 pF1KE1 L--ESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHF : . . .::: :. .: : :...::.: :. :. :.:...: : :. : . CCDS58 CTPEFYQTHFQLAYRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGY 180 190 200 210 220 230 200 210 220 230 240 250 pF1KE1 MVEVKGDLTAKKMVLALLELAQQD-HGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPV :.: : ::..: : ..:: : . : :.:..:::: . ::.::.:: . CCDS58 DVHVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVE-------GAIYGVDGKLL 240 250 260 270 280 290 260 270 280 290 300 310 pF1KE1 SVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATP ..... ..:....:::: .:::.:::::: :.. :.: . . . . ::: . : :: CCDS58 QLQEVFQLFDNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCE-ESDA-- 300 310 320 330 340 320 330 340 350 360 370 pF1KE1 FQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSE : . . .. ::: ::.. .:. . : .. :. : ::::.:.: ..: . : . CCDS58 ---GKEKLPKM----RLPTRSDMICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDM 350 360 370 380 390 400 380 390 400 410 pF1KE1 DLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS . ..:..: ::. .: :: .: : : CCDS58 HVADMLVKV-NAL-IKDREGYAPGT-EFHRCKEMSEYCSTLCRHLYLFPGHPPT 410 420 430 440 450 >>CCDS3836.1 CASP3 gene_id:836|Hs108|chr4 (277 aa) initn: 509 init1: 221 opt: 392 Z-score: 450.1 bits: 91.7 E(32554): 9.4e-19 Smith-Waterman score: 514; 33.2% identity (61.3% similar) in 274 aa overlap (150-413:34-275) 120 130 140 150 160 170 pF1KE1 VLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRT : .: ... : :.:::: :: . .:. . CCDS38 TENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTS 10 20 30 40 50 60 180 190 200 210 220 230 pF1KE1 RTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGC :.:...: .::. : .:.. :. :.::: ...: . .....::. . : :.:::: CCDS38 RSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGE 70 80 90 100 110 120 240 250 260 270 280 290 pF1KE1 QASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVA . : ..::.: ::...::.:.: : : :: ::::::.:::: : . : :.:. CCDS38 E-------GIIFGTNG-PVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETD 130 140 150 160 170 300 310 320 330 340 350 pF1KE1 STSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKS : .: : ..:. .:.. .::: ::. :::. :. CCDS38 SGVDDDM------------------------ACHKIPVEADFLYAYSTAPGYYSWRNSKD 180 190 200 210 360 370 380 390 400 pF1KE1 GSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVK----------GIYKQMPGCFNFLRK :::....: ...:.: . ... .: :: :... ::.: ..: : CCDS38 GSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTK 220 230 240 250 260 270 410 pF1KE1 KLFFKTS .:.: CCDS38 ELYFYH >>CCDS2343.1 CASP8 gene_id:841|Hs108|chr2 (464 aa) initn: 394 init1: 199 opt: 391 Z-score: 445.6 bits: 91.6 E(32554): 1.7e-18 Smith-Waterman score: 486; 34.1% identity (60.9% similar) in 279 aa overlap (150-415:208-463) 120 130 140 150 160 170 pF1KE1 VLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFC--RES-- : .: .. .: :.:::::: :: ::. CCDS23 YEEFSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVP 180 190 200 210 220 230 180 190 200 210 220 230 pF1KE1 ---GLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQ-QDHGALDCCV ..: :.:...: : : ::: .. . : :... . .:.. : .::. .:: . CCDS23 KLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQ-IYEILKIYQLMDHSNMDCFI 240 250 260 270 280 290 240 250 260 270 280 290 pF1KE1 VVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQ ::::: . : .::::: . . .... :.: .::::.::::.:::::: :.. CCDS23 CCILSHGDK-------GIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDN 300 310 320 330 340 300 310 320 330 340 350 pF1KE1 KDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGF ..:. : . : :. :. : . : : : .:......: . CCDS23 YQKGIPVETDSEEQ------------PYLEMDLSSPQTRYI---PDEADFLLGMATVNNC 350 360 370 380 390 360 370 380 390 400 pF1KE1 VSWRDPKSGSWYVETL-DDIFEQWAHSEDLQSLLLRVANAVSVK----GIYKQMPGCFNF ::.:.: :.::...: ... :. ...:. ..: .: :: : .. :::: CCDS23 VSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFT 400 410 420 430 440 450 410 pF1KE1 LRKKLFFKTS ::::: : . CCDS23 LRKKLVFPSD 460 >>CCDS2342.1 CASP8 gene_id:841|Hs108|chr2 (479 aa) initn: 394 init1: 199 opt: 391 Z-score: 445.4 bits: 91.6 E(32554): 1.7e-18 Smith-Waterman score: 486; 34.1% identity (60.9% similar) in 279 aa overlap (150-415:223-478) 120 130 140 150 160 170 pF1KE1 VLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFC--RES-- : .: .. .: :.:::::: :: ::. CCDS23 PDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVP 200 210 220 230 240 250 180 190 200 210 220 230 pF1KE1 ---GLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQ-QDHGALDCCV ..: :.:...: : : ::: .. . : :... . .:.. : .::. .:: . CCDS23 KLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQ-IYEILKIYQLMDHSNMDCFI 260 270 280 290 300 310 240 250 260 270 280 290 pF1KE1 VVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQ ::::: . : .::::: . . .... :.: .::::.::::.:::::: :.. CCDS23 CCILSHGDK-------GIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDN 320 330 340 350 360 300 310 320 330 340 350 pF1KE1 KDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGF ..:. : . : :. :. : . : : : .:......: . CCDS23 YQKGIPVETDSEEQ------------PYLEMDLSSPQTRYI---PDEADFLLGMATVNNC 370 380 390 400 360 370 380 390 400 pF1KE1 VSWRDPKSGSWYVETL-DDIFEQWAHSEDLQSLLLRVANAVSVK----GIYKQMPGCFNF ::.:.: :.::...: ... :. ...:. ..: .: :: : .. :::: CCDS23 VSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFT 410 420 430 440 450 460 410 pF1KE1 LRKKLFFKTS ::::: : . CCDS23 LRKKLVFPSD 470 >>CCDS42799.1 CASP8 gene_id:841|Hs108|chr2 (496 aa) initn: 394 init1: 199 opt: 391 Z-score: 445.1 bits: 91.6 E(32554): 1.8e-18 Smith-Waterman score: 486; 34.1% identity (60.9% similar) in 279 aa overlap (150-415:240-495) 120 130 140 150 160 170 pF1KE1 VLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFC--RES-- : .: .. .: :.:::::: :: ::. CCDS42 YEEFSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVP 210 220 230 240 250 260 180 190 200 210 220 230 pF1KE1 ---GLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQ-QDHGALDCCV ..: :.:...: : : ::: .. . : :... . .:.. : .::. .:: . CCDS42 KLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQ-IYEILKIYQLMDHSNMDCFI 270 280 290 300 310 320 240 250 260 270 280 290 pF1KE1 VVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQ ::::: . : .::::: . . .... :.: .::::.::::.:::::: :.. CCDS42 CCILSHGDK-------GIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDN 330 340 350 360 370 380 300 310 320 330 340 350 pF1KE1 KDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGF ..:. : . : :. :. : . : : : .:......: . CCDS42 YQKGIPVETDSEEQ------------PYLEMDLSSPQTRYI---PDEADFLLGMATVNNC 390 400 410 420 360 370 380 390 400 pF1KE1 VSWRDPKSGSWYVETL-DDIFEQWAHSEDLQSLLLRVANAVSVK----GIYKQMPGCFNF ::.:.: :.::...: ... :. ...:. ..: .: :: : .. :::: CCDS42 VSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFT 430 440 450 460 470 480 410 pF1KE1 LRKKLFFKTS ::::: : . CCDS42 LRKKLVFPSD 490 >>CCDS42798.1 CASP8 gene_id:841|Hs108|chr2 (538 aa) initn: 394 init1: 199 opt: 391 Z-score: 444.6 bits: 91.6 E(32554): 1.9e-18 Smith-Waterman score: 486; 34.1% identity (60.9% similar) in 279 aa overlap (150-415:282-537) 120 130 140 150 160 170 pF1KE1 VLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFC--RES-- : .: .. .: :.:::::: :: ::. CCDS42 PDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVP 260 270 280 290 300 310 180 190 200 210 220 230 pF1KE1 ---GLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQ-QDHGALDCCV ..: :.:...: : : ::: .. . : :... . .:.. : .::. .:: . CCDS42 KLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQ-IYEILKIYQLMDHSNMDCFI 320 330 340 350 360 370 240 250 260 270 280 290 pF1KE1 VVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQ ::::: . : .::::: . . .... :.: .::::.::::.:::::: :.. CCDS42 CCILSHGDK-------GIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDN 380 390 400 410 420 300 310 320 330 340 350 pF1KE1 KDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGF ..:. : . : :. :. : . : : : .:......: . CCDS42 YQKGIPVETDSEEQ------------PYLEMDLSSPQTRYI---PDEADFLLGMATVNNC 430 440 450 460 360 370 380 390 400 pF1KE1 VSWRDPKSGSWYVETL-DDIFEQWAHSEDLQSLLLRVANAVSVK----GIYKQMPGCFNF ::.:.: :.::...: ... :. ...:. ..: .: :: : .. :::: CCDS42 VSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFT 470 480 490 500 510 520 410 pF1KE1 LRKKLFFKTS ::::: : . CCDS42 LRKKLVFPSD 530 >>CCDS58096.1 CASP7 gene_id:840|Hs108|chr10 (278 aa) initn: 438 init1: 200 opt: 320 Z-score: 368.1 bits: 76.5 E(32554): 3.5e-14 Smith-Waterman score: 458; 33.3% identity (59.0% similar) in 273 aa overlap (153-413:35-276) 130 140 150 160 170 180 pF1KE1 PETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTRTG : ...: :.:.:::: :: . .:. .:.: CCDS58 LFSDGDTSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNG 10 20 30 40 50 60 190 200 210 220 230 240 pF1KE1 SNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQAS .. : : : . : :: : : : .: . :: : . ...:: : . ..:::: . CCDS58 TDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGEE-- 70 80 90 100 110 120 250 260 270 280 290 300 pF1KE1 HLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTS ...:: :: . .. .. : : : .: :::::::::: : . : :.. :... CCDS58 -----NVIYGKDGV-TPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQ-ADSG 130 140 150 160 170 310 320 330 340 350 360 pF1KE1 PEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSW : ... ::.: . .:. .:.. .::: ::. :::.: ::: CCDS58 PINDT-------DANPRYK-------------IPVEADFLFAYSTVPGYYSWRSPGRGSW 180 190 200 210 370 380 390 400 410 pF1KE1 YVETLDDIFEQWAHSEDLQ--SLLLRVANAVSVK----------GIYKQMPGCFNFLRKK .:..: .:.:. :..::. ..: :: . :. . ::.: ..: :. CCDS58 FVQALCSILEE--HGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKE 220 230 240 250 260 270 pF1KE1 LFFKTS :.: CCDS58 LYFSQ 416 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon May 22 10:33:28 2017 done: Mon May 22 10:33:29 2017 Total Scan time: 3.180 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]