FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1327, 469 aa 1>>>pF1KE1327 469 - 469 aa - 469 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.8836+/-0.000334; mu= 16.2131+/- 0.021 mean_var=105.3260+/-21.886, 0's: 0 Z-trim(116.9): 93 B-trim: 0 in 0/57 Lambda= 0.124970 statistics sampled from 28363 (28478) to 28363 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.688), E-opt: 0.2 (0.334), width: 16 Scan time: 9.950 The best scores are: opt bits E(85289) NP_001070984 (OMIM: 601416) zinc transporter SLC39 ( 469) 3231 593.2 4.9e-169 NP_008910 (OMIM: 601416) zinc transporter SLC39A7 ( 469) 3231 593.2 4.9e-169 NP_001275706 (OMIM: 601416) zinc transporter SLC39 ( 344) 2168 401.5 1.9e-111 XP_011518769 (OMIM: 608735,612350) PREDICTED: zinc ( 371) 509 102.4 2.2e-21 NP_001121697 (OMIM: 608735,612350) zinc transporte ( 371) 509 102.4 2.2e-21 XP_011518770 (OMIM: 608735,612350) PREDICTED: zinc ( 371) 509 102.4 2.2e-21 XP_011518768 (OMIM: 608735,612350) PREDICTED: zinc ( 386) 509 102.4 2.3e-21 XP_011518772 (OMIM: 608735,612350) PREDICTED: zinc ( 335) 500 100.7 6.4e-21 XP_011518771 (OMIM: 608735,612350) PREDICTED: zinc ( 350) 500 100.7 6.6e-21 NP_689477 (OMIM: 608735,612350) zinc transporter Z ( 364) 487 98.4 3.4e-20 XP_016874029 (OMIM: 608735,612350) PREDICTED: zinc ( 364) 487 98.4 3.4e-20 XP_006718444 (OMIM: 608735,612350) PREDICTED: zinc ( 379) 487 98.4 3.5e-20 XP_016874030 (OMIM: 608735,612350) PREDICTED: zinc ( 328) 478 96.8 9.8e-20 XP_006718446 (OMIM: 608735,612350) PREDICTED: zinc ( 343) 478 96.8 1e-19 NP_060237 (OMIM: 201100,607059) zinc transporter Z ( 622) 418 86.2 2.8e-16 NP_570901 (OMIM: 201100,607059) zinc transporter Z ( 647) 418 86.2 2.9e-16 NP_775867 (OMIM: 608730,615946) zinc transporter Z ( 540) 398 82.5 3.1e-15 XP_011536503 (OMIM: 608730,615946) PREDICTED: zinc ( 540) 398 82.5 3.1e-15 XP_011536502 (OMIM: 608730,615946) PREDICTED: zinc ( 540) 398 82.5 3.1e-15 XP_011536501 (OMIM: 608730,615946) PREDICTED: zinc ( 540) 398 82.5 3.1e-15 XP_011536500 (OMIM: 608730,615946) PREDICTED: zinc ( 540) 398 82.5 3.1e-15 XP_005268860 (OMIM: 608730,615946) PREDICTED: zinc ( 540) 398 82.5 3.1e-15 NP_001128667 (OMIM: 608730,615946) zinc transporte ( 540) 398 82.5 3.1e-15 NP_001269663 (OMIM: 608734) zinc transporter ZIP12 ( 557) 382 79.7 2.3e-14 NP_001138667 (OMIM: 608734) zinc transporter ZIP12 ( 691) 382 79.7 2.7e-14 NP_001269662 (OMIM: 608734) zinc transporter ZIP12 ( 690) 380 79.4 3.5e-14 XP_016874676 (OMIM: 608730,615946) PREDICTED: zinc ( 288) 361 75.6 2e-13 XP_016874675 (OMIM: 608730,615946) PREDICTED: zinc ( 288) 361 75.6 2e-13 NP_001120729 (OMIM: 608733) zinc transporter ZIP10 ( 831) 362 76.2 3.8e-13 XP_005246746 (OMIM: 608733) PREDICTED: zinc transp ( 831) 362 76.2 3.8e-13 NP_065075 (OMIM: 608733) zinc transporter ZIP10 pr ( 831) 362 76.2 3.8e-13 XP_011509806 (OMIM: 608733) PREDICTED: zinc transp ( 831) 362 76.2 3.8e-13 XP_011509807 (OMIM: 608733) PREDICTED: zinc transp ( 831) 362 76.2 3.8e-13 XP_011509808 (OMIM: 608733) PREDICTED: zinc transp ( 831) 362 76.2 3.8e-13 NP_001267486 (OMIM: 201100,607059) zinc transporte ( 149) 336 70.9 2.8e-12 NP_001317174 (OMIM: 608735,612350) zinc transporte ( 325) 321 68.4 3.2e-11 XP_006718447 (OMIM: 608735,612350) PREDICTED: zinc ( 340) 321 68.5 3.3e-11 XP_006718448 (OMIM: 608735,612350) PREDICTED: zinc ( 304) 312 66.8 9.5e-11 NP_689938 (OMIM: 608734) zinc transporter ZIP12 is ( 654) 313 67.3 1.5e-10 XP_011524203 (OMIM: 608731) PREDICTED: zinc transp ( 755) 312 67.1 1.8e-10 XP_011524202 (OMIM: 608731) PREDICTED: zinc transp ( 755) 312 67.1 1.8e-10 NP_036451 (OMIM: 608731) zinc transporter ZIP6 iso ( 755) 312 67.1 1.8e-10 XP_005273523 (OMIM: 608736,617013) PREDICTED: zinc ( 492) 305 65.7 3.2e-10 XP_016868783 (OMIM: 608736,617013) PREDICTED: zinc ( 492) 305 65.7 3.2e-10 NP_001128625 (OMIM: 608736,617013) zinc transporte ( 492) 305 65.7 3.2e-10 XP_006716387 (OMIM: 608736,617013) PREDICTED: zinc ( 492) 305 65.7 3.2e-10 XP_011542780 (OMIM: 608736,617013) PREDICTED: zinc ( 492) 305 65.7 3.2e-10 NP_001121903 (OMIM: 608736,617013) zinc transporte ( 492) 305 65.7 3.2e-10 XP_016868784 (OMIM: 608736,617013) PREDICTED: zinc ( 492) 305 65.7 3.2e-10 XP_005273522 (OMIM: 608736,617013) PREDICTED: zinc ( 492) 305 65.7 3.2e-10 >>NP_001070984 (OMIM: 601416) zinc transporter SLC39A7 i (469 aa) initn: 3231 init1: 3231 opt: 3231 Z-score: 3155.7 bits: 593.2 E(85289): 4.9e-169 Smith-Waterman score: 3231; 100.0% identity (100.0% similar) in 469 aa overlap (1-469:1-469) 10 20 30 40 50 60 pF1KE1 MARGLGAPHWVAVGLLTWATLGLLVAGLGGHDDLHDDLQEDFHGHSHRHSHEDFHHGHSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MARGLGAPHWVAVGLLTWATLGLLVAGLGGHDDLHDDLQEDFHGHSHRHSHEDFHHGHSH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 AHGHGHTHESIWHGHTHDHDHGHSHEDLHHGHSHGYSHESLYHRGHGHDHEHSHGGYGES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AHGHGHTHESIWHGHTHDHDHGHSHEDLHHGHSHGYSHESLYHRGHGHDHEHSHGGYGES 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 GAPGIKQDLDAVTLWAYALGATVLISAAPFFVLFLIPVESNSPRHRSLLQILLSFASGGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GAPGIKQDLDAVTLWAYALGATVLISAAPFFVLFLIPVESNSPRHRSLLQILLSFASGGL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 LGDAFLHLIPHALEPHSHHTLEQPGHGHSHSGQGPILSVGLWVLSGIVAFLVVEKFVRHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGDAFLHLIPHALEPHSHHTLEQPGHGHSHSGQGPILSVGLWVLSGIVAFLVVEKFVRHV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 KGGHGHSHGHGHAHSHTRGSHGHGRQERSTKEKQSSEEEEKETRGVQKRRGGSTVPKDGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KGGHGHSHGHGHAHSHTRGSHGHGRQERSTKEKQSSEEEEKETRGVQKRRGGSTVPKDGP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 VRPQNAEEEKRGLDLRVSGYLNLAADLAHNFTDGLAIGASFRGGRGLGILTTMTVLLHEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VRPQNAEEEKRGLDLRVSGYLNLAADLAHNFTDGLAIGASFRGGRGLGILTTMTVLLHEV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 PHEVGDFAILVQSGCSKKQAMRLQLLTAVGALAGTACALLTEGGAVGSEIAGGAGPGWVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PHEVGDFAILVQSGCSKKQAMRLQLLTAVGALAGTACALLTEGGAVGSEIAGGAGPGWVL 370 380 390 400 410 420 430 440 450 460 pF1KE1 PFTAGGFIYVATVSVLPELLREASPLQSLLEVLGLLGGVIMMVLIAHLE ::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PFTAGGFIYVATVSVLPELLREASPLQSLLEVLGLLGGVIMMVLIAHLE 430 440 450 460 >>NP_008910 (OMIM: 601416) zinc transporter SLC39A7 isof (469 aa) initn: 3231 init1: 3231 opt: 3231 Z-score: 3155.7 bits: 593.2 E(85289): 4.9e-169 Smith-Waterman score: 3231; 100.0% identity (100.0% similar) in 469 aa overlap (1-469:1-469) 10 20 30 40 50 60 pF1KE1 MARGLGAPHWVAVGLLTWATLGLLVAGLGGHDDLHDDLQEDFHGHSHRHSHEDFHHGHSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 MARGLGAPHWVAVGLLTWATLGLLVAGLGGHDDLHDDLQEDFHGHSHRHSHEDFHHGHSH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 AHGHGHTHESIWHGHTHDHDHGHSHEDLHHGHSHGYSHESLYHRGHGHDHEHSHGGYGES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 AHGHGHTHESIWHGHTHDHDHGHSHEDLHHGHSHGYSHESLYHRGHGHDHEHSHGGYGES 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 GAPGIKQDLDAVTLWAYALGATVLISAAPFFVLFLIPVESNSPRHRSLLQILLSFASGGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 GAPGIKQDLDAVTLWAYALGATVLISAAPFFVLFLIPVESNSPRHRSLLQILLSFASGGL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 LGDAFLHLIPHALEPHSHHTLEQPGHGHSHSGQGPILSVGLWVLSGIVAFLVVEKFVRHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 LGDAFLHLIPHALEPHSHHTLEQPGHGHSHSGQGPILSVGLWVLSGIVAFLVVEKFVRHV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 KGGHGHSHGHGHAHSHTRGSHGHGRQERSTKEKQSSEEEEKETRGVQKRRGGSTVPKDGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 KGGHGHSHGHGHAHSHTRGSHGHGRQERSTKEKQSSEEEEKETRGVQKRRGGSTVPKDGP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 VRPQNAEEEKRGLDLRVSGYLNLAADLAHNFTDGLAIGASFRGGRGLGILTTMTVLLHEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 VRPQNAEEEKRGLDLRVSGYLNLAADLAHNFTDGLAIGASFRGGRGLGILTTMTVLLHEV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 PHEVGDFAILVQSGCSKKQAMRLQLLTAVGALAGTACALLTEGGAVGSEIAGGAGPGWVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 PHEVGDFAILVQSGCSKKQAMRLQLLTAVGALAGTACALLTEGGAVGSEIAGGAGPGWVL 370 380 390 400 410 420 430 440 450 460 pF1KE1 PFTAGGFIYVATVSVLPELLREASPLQSLLEVLGLLGGVIMMVLIAHLE ::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 PFTAGGFIYVATVSVLPELLREASPLQSLLEVLGLLGGVIMMVLIAHLE 430 440 450 460 >>NP_001275706 (OMIM: 601416) zinc transporter SLC39A7 i (344 aa) initn: 2168 init1: 2168 opt: 2168 Z-score: 2121.7 bits: 401.5 E(85289): 1.9e-111 Smith-Waterman score: 2168; 100.0% identity (100.0% similar) in 329 aa overlap (141-469:16-344) 120 130 140 150 160 170 pF1KE1 EHSHGGYGESGAPGIKQDLDAVTLWAYALGATVLISAAPFFVLFLIPVESNSPRHRSLLQ :::::::::::::::::::::::::::::: NP_001 MTTCTTICKRTSMATATVLISAAPFFVLFLIPVESNSPRHRSLLQ 10 20 30 40 180 190 200 210 220 230 pF1KE1 ILLSFASGGLLGDAFLHLIPHALEPHSHHTLEQPGHGHSHSGQGPILSVGLWVLSGIVAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILLSFASGGLLGDAFLHLIPHALEPHSHHTLEQPGHGHSHSGQGPILSVGLWVLSGIVAF 50 60 70 80 90 100 240 250 260 270 280 290 pF1KE1 LVVEKFVRHVKGGHGHSHGHGHAHSHTRGSHGHGRQERSTKEKQSSEEEEKETRGVQKRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVVEKFVRHVKGGHGHSHGHGHAHSHTRGSHGHGRQERSTKEKQSSEEEEKETRGVQKRR 110 120 130 140 150 160 300 310 320 330 340 350 pF1KE1 GGSTVPKDGPVRPQNAEEEKRGLDLRVSGYLNLAADLAHNFTDGLAIGASFRGGRGLGIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GGSTVPKDGPVRPQNAEEEKRGLDLRVSGYLNLAADLAHNFTDGLAIGASFRGGRGLGIL 170 180 190 200 210 220 360 370 380 390 400 410 pF1KE1 TTMTVLLHEVPHEVGDFAILVQSGCSKKQAMRLQLLTAVGALAGTACALLTEGGAVGSEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TTMTVLLHEVPHEVGDFAILVQSGCSKKQAMRLQLLTAVGALAGTACALLTEGGAVGSEI 230 240 250 260 270 280 420 430 440 450 460 pF1KE1 AGGAGPGWVLPFTAGGFIYVATVSVLPELLREASPLQSLLEVLGLLGGVIMMVLIAHLE ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AGGAGPGWVLPFTAGGFIYVATVSVLPELLREASPLQSLLEVLGLLGGVIMMVLIAHLE 290 300 310 320 330 340 >>XP_011518769 (OMIM: 608735,612350) PREDICTED: zinc tra (371 aa) initn: 668 init1: 311 opt: 509 Z-score: 504.8 bits: 102.4 E(85289): 2.2e-21 Smith-Waterman score: 634; 37.0% identity (63.6% similar) in 357 aa overlap (119-466:52-367) 90 100 110 120 130 140 pF1KE1 HHGHSHGYSHESLYHRGHGHDHEHSHGGYGESGAPGIKQDLDAVTLWAYALGATVLISAA :: . : . . . : .: ...... . XP_011 LALELLERAGGSQPALRSRGTATACRLDNKESESWGALLSGERLDTWICSLLGSLMVGLS 30 40 50 60 70 80 150 160 170 180 190 200 pF1KE1 PFFVLFLIPVESNSP-RHRS---LLQILLSFASGGLLGDAFLHLIPHALEPHSHHTLEQP : :..::.: .. : .. :. ::::: :::::..::::.:.: .. .: XP_011 GVFPLLVIPLEMGTMLRSEAGAWRLKQLLSFALGGLLGNVFLHLLPEAW---AYTCSASP 90 100 110 120 130 210 220 230 240 250 260 pF1KE1 GHGHSHSGQGPILSVGLWVLSGIVAFLVVEKFVRHVKGGHGHSHGHGHAHSHTRGSHGHG : :...: : ..::::..::..::..::. XP_011 G-GEGQSLQQQ-QQLGLWVIAGILTFLALEKMFL-------------------------- 140 150 160 170 270 280 290 300 310 320 pF1KE1 RQERSTKEKQSSEEEEKETRGVQKRRGGSTVPKDGPVRPQNAEEEKRGL---DLRVSGYL ..::. .:. .:. .. .: : : : : : ...::::: XP_011 ----DSKEEGTSQAPNKDPTAAAAALNG------GHCLAQPAAEPGLGAVVRSIKVSGYL 180 190 200 210 220 330 340 350 360 370 380 pF1KE1 NLAADLAHNFTDGLAIGASFRGGRGLGILTTMTVLLHEVPHEVGDFAILVQSGCSKKQAM :: :. ::: :::..::: .. .:.::::..::::.::::::::::...: .. .: XP_011 NLLANTIDNFTHGLAVAASFLVSKKIGLLTTMAILLHEIPHEVGDFAILLRAGFDRWSAA 230 240 250 260 270 280 390 400 410 420 430 pF1KE1 RLQLLTAVGALAGTACALLTEG--GAVGSEIAGGAGPGWVLPFTAGGFIYVATVSVLPEL .::: ::.:.: :.. :. :.. :.:: :. .::::::.:::.:.: :.:::.: XP_011 KLQLSTALGGLLGAGFAICTQSPKGVVGCSPAAEETAAWVLPFTSGGFLYIALVNVLPDL 290 300 310 320 330 340 440 450 460 pF1KE1 LREASPLQSLLEVLGLLGGVIMMVLIAHLE :.: .: .:: ..: : .:...:::.. XP_011 LEEEDPWRSLQQLLLLCAGIVVMVLFSLFVD 350 360 370 >>NP_001121697 (OMIM: 608735,612350) zinc transporter ZI (371 aa) initn: 668 init1: 311 opt: 509 Z-score: 504.8 bits: 102.4 E(85289): 2.2e-21 Smith-Waterman score: 634; 37.0% identity (63.6% similar) in 357 aa overlap (119-466:52-367) 90 100 110 120 130 140 pF1KE1 HHGHSHGYSHESLYHRGHGHDHEHSHGGYGESGAPGIKQDLDAVTLWAYALGATVLISAA :: . : . . . : .: ...... . NP_001 LALELLGRAGGSQPALRSRGTATACRLDNKESESWGALLSGERLDTWICSLLGSLMVGLS 30 40 50 60 70 80 150 160 170 180 190 200 pF1KE1 PFFVLFLIPVESNSP-RHRS---LLQILLSFASGGLLGDAFLHLIPHALEPHSHHTLEQP : :..::.: .. : .. :. ::::: :::::..::::.:.: .. .: NP_001 GVFPLLVIPLEMGTMLRSEAGAWRLKQLLSFALGGLLGNVFLHLLPEAW---AYTCSASP 90 100 110 120 130 210 220 230 240 250 260 pF1KE1 GHGHSHSGQGPILSVGLWVLSGIVAFLVVEKFVRHVKGGHGHSHGHGHAHSHTRGSHGHG : :...: : ..::::..::..::..::. NP_001 G-GEGQSLQQQ-QQLGLWVIAGILTFLALEKMFL-------------------------- 140 150 160 170 270 280 290 300 310 320 pF1KE1 RQERSTKEKQSSEEEEKETRGVQKRRGGSTVPKDGPVRPQNAEEEKRGL---DLRVSGYL ..::. .:. .:. .. .: : : : : : ...::::: NP_001 ----DSKEEGTSQAPNKDPTAAAAALNG------GHCLAQPAAEPGLGAVVRSIKVSGYL 180 190 200 210 220 330 340 350 360 370 380 pF1KE1 NLAADLAHNFTDGLAIGASFRGGRGLGILTTMTVLLHEVPHEVGDFAILVQSGCSKKQAM :: :. ::: :::..::: .. .:.::::..::::.::::::::::...: .. .: NP_001 NLLANTIDNFTHGLAVAASFLVSKKIGLLTTMAILLHEIPHEVGDFAILLRAGFDRWSAA 230 240 250 260 270 280 390 400 410 420 430 pF1KE1 RLQLLTAVGALAGTACALLTEG--GAVGSEIAGGAGPGWVLPFTAGGFIYVATVSVLPEL .::: ::.:.: :.. :. :.. :.:: :. .::::::.:::.:.: :.:::.: NP_001 KLQLSTALGGLLGAGFAICTQSPKGVVGCSPAAEETAAWVLPFTSGGFLYIALVNVLPDL 290 300 310 320 330 340 440 450 460 pF1KE1 LREASPLQSLLEVLGLLGGVIMMVLIAHLE :.: .: .:: ..: : .:...:::.. NP_001 LEEEDPWRSLQQLLLLCAGIVVMVLFSLFVD 350 360 370 >>XP_011518770 (OMIM: 608735,612350) PREDICTED: zinc tra (371 aa) initn: 668 init1: 311 opt: 509 Z-score: 504.8 bits: 102.4 E(85289): 2.2e-21 Smith-Waterman score: 634; 37.0% identity (63.6% similar) in 357 aa overlap (119-466:52-367) 90 100 110 120 130 140 pF1KE1 HHGHSHGYSHESLYHRGHGHDHEHSHGGYGESGAPGIKQDLDAVTLWAYALGATVLISAA :: . : . . . : .: ...... . XP_011 LALELLERAGGSQPALRSRGTATACRLDNKESESWGALLSGERLDTWICSLLGSLMVGLS 30 40 50 60 70 80 150 160 170 180 190 200 pF1KE1 PFFVLFLIPVESNSP-RHRS---LLQILLSFASGGLLGDAFLHLIPHALEPHSHHTLEQP : :..::.: .. : .. :. ::::: :::::..::::.:.: .. .: XP_011 GVFPLLVIPLEMGTMLRSEAGAWRLKQLLSFALGGLLGNVFLHLLPEAW---AYTCSASP 90 100 110 120 130 210 220 230 240 250 260 pF1KE1 GHGHSHSGQGPILSVGLWVLSGIVAFLVVEKFVRHVKGGHGHSHGHGHAHSHTRGSHGHG : :...: : ..::::..::..::..::. XP_011 G-GEGQSLQQQ-QQLGLWVIAGILTFLALEKMFL-------------------------- 140 150 160 170 270 280 290 300 310 320 pF1KE1 RQERSTKEKQSSEEEEKETRGVQKRRGGSTVPKDGPVRPQNAEEEKRGL---DLRVSGYL ..::. .:. .:. .. .: : : : : : ...::::: XP_011 ----DSKEEGTSQAPNKDPTAAAAALNG------GHCLAQPAAEPGLGAVVRSIKVSGYL 180 190 200 210 220 330 340 350 360 370 380 pF1KE1 NLAADLAHNFTDGLAIGASFRGGRGLGILTTMTVLLHEVPHEVGDFAILVQSGCSKKQAM :: :. ::: :::..::: .. .:.::::..::::.::::::::::...: .. .: XP_011 NLLANTIDNFTHGLAVAASFLVSKKIGLLTTMAILLHEIPHEVGDFAILLRAGFDRWSAA 230 240 250 260 270 280 390 400 410 420 430 pF1KE1 RLQLLTAVGALAGTACALLTEG--GAVGSEIAGGAGPGWVLPFTAGGFIYVATVSVLPEL .::: ::.:.: :.. :. :.. :.:: :. .::::::.:::.:.: :.:::.: XP_011 KLQLSTALGGLLGAGFAICTQSPKGVVGCSPAAEETAAWVLPFTSGGFLYIALVNVLPDL 290 300 310 320 330 340 440 450 460 pF1KE1 LREASPLQSLLEVLGLLGGVIMMVLIAHLE :.: .: .:: ..: : .:...:::.. XP_011 LEEEDPWRSLQQLLLLCAGIVVMVLFSLFVD 350 360 370 >>XP_011518768 (OMIM: 608735,612350) PREDICTED: zinc tra (386 aa) initn: 668 init1: 311 opt: 509 Z-score: 504.6 bits: 102.4 E(85289): 2.3e-21 Smith-Waterman score: 634; 37.0% identity (63.6% similar) in 357 aa overlap (119-466:67-382) 90 100 110 120 130 140 pF1KE1 HHGHSHGYSHESLYHRGHGHDHEHSHGGYGESGAPGIKQDLDAVTLWAYALGATVLISAA :: . : . . . : .: ...... . XP_011 LALELLERAGGSQPALRSRGTATACRLDNKESESWGALLSGERLDTWICSLLGSLMVGLS 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE1 PFFVLFLIPVESNSP-RHRS---LLQILLSFASGGLLGDAFLHLIPHALEPHSHHTLEQP : :..::.: .. : .. :. ::::: :::::..::::.:.: .. .: XP_011 GVFPLLVIPLEMGTMLRSEAGAWRLKQLLSFALGGLLGNVFLHLLPEAW---AYTCSASP 100 110 120 130 140 150 210 220 230 240 250 260 pF1KE1 GHGHSHSGQGPILSVGLWVLSGIVAFLVVEKFVRHVKGGHGHSHGHGHAHSHTRGSHGHG : :...: : ..::::..::..::..::. XP_011 G-GEGQSLQQQ-QQLGLWVIAGILTFLALEKMFL-------------------------- 160 170 180 270 280 290 300 310 320 pF1KE1 RQERSTKEKQSSEEEEKETRGVQKRRGGSTVPKDGPVRPQNAEEEKRGL---DLRVSGYL ..::. .:. .:. .. .: : : : : : ...::::: XP_011 ----DSKEEGTSQAPNKDPTAAAAALNG------GHCLAQPAAEPGLGAVVRSIKVSGYL 190 200 210 220 230 330 340 350 360 370 380 pF1KE1 NLAADLAHNFTDGLAIGASFRGGRGLGILTTMTVLLHEVPHEVGDFAILVQSGCSKKQAM :: :. ::: :::..::: .. .:.::::..::::.::::::::::...: .. .: XP_011 NLLANTIDNFTHGLAVAASFLVSKKIGLLTTMAILLHEIPHEVGDFAILLRAGFDRWSAA 240 250 260 270 280 290 390 400 410 420 430 pF1KE1 RLQLLTAVGALAGTACALLTEG--GAVGSEIAGGAGPGWVLPFTAGGFIYVATVSVLPEL .::: ::.:.: :.. :. :.. :.:: :. .::::::.:::.:.: :.:::.: XP_011 KLQLSTALGGLLGAGFAICTQSPKGVVGCSPAAEETAAWVLPFTSGGFLYIALVNVLPDL 300 310 320 330 340 350 440 450 460 pF1KE1 LREASPLQSLLEVLGLLGGVIMMVLIAHLE :.: .: .:: ..: : .:...:::.. XP_011 LEEEDPWRSLQQLLLLCAGIVVMVLFSLFVD 360 370 380 >>XP_011518772 (OMIM: 608735,612350) PREDICTED: zinc tra (335 aa) initn: 664 init1: 307 opt: 500 Z-score: 496.6 bits: 100.7 E(85289): 6.4e-21 Smith-Waterman score: 558; 35.6% identity (60.2% similar) in 354 aa overlap (119-466:52-331) 90 100 110 120 130 140 pF1KE1 HHGHSHGYSHESLYHRGHGHDHEHSHGGYGESGAPGIKQDLDAVTLWAYALGATVLISAA :: . : . . . : .: ...... . XP_011 LALELLERAGGSQPALRSRGTATACRLDNKESESWGALLSGERLDTWICSLLGSLMVGLS 30 40 50 60 70 80 150 160 170 180 190 200 pF1KE1 PFFVLFLIPVESNSP-RHRS---LLQILLSFASGGLLGDAFLHLIPHALEPHSHHTLEQP : :..::.: .. : .. :. ::::: :::::..::::.:.: .. .: XP_011 GVFPLLVIPLEMGTMLRSEAGAWRLKQLLSFALGGLLGNVFLHLLPEAW---AYTCSASP 90 100 110 120 130 210 220 230 240 250 260 pF1KE1 GHGHSHSGQGPILSVGLWVLSGIVAFLVVEKFVRHVKGGHGHSHGHGHAHSHTRGSHGHG : :...: : ..::::..::..::..::. XP_011 G-GEGQSLQQQ-QQLGLWVIAGILTFLALEKMF--------------------------- 140 150 160 270 280 290 300 310 320 pF1KE1 RQERSTKEKQSSEEEEKETRGVQKRRGGSTVPKDGPVRPQNAEEEKRGLDLRVSGYLNLA .:.:: :.. .::::::: XP_011 ---------LDSKEE------------GTS---------------------QVSGYLNLL 170 180 330 340 350 360 370 380 pF1KE1 ADLAHNFTDGLAIGASFRGGRGLGILTTMTVLLHEVPHEVGDFAILVQSGCSKKQAMRLQ :. ::: :::..::: .. .:.::::..::::.::::::::::...: .. .: .:: XP_011 ANTIDNFTHGLAVAASFLVSKKIGLLTTMAILLHEIPHEVGDFAILLRAGFDRWSAAKLQ 190 200 210 220 230 240 390 400 410 420 430 440 pF1KE1 LLTAVGALAGTACALLTEG--GAVGSEIAGGAGPGWVLPFTAGGFIYVATVSVLPELLRE : ::.:.: :.. :. :.. :.:: :. .::::::.:::.:.: :.:::.::.: XP_011 LSTALGGLLGAGFAICTQSPKGVVGCSPAAEETAAWVLPFTSGGFLYIALVNVLPDLLEE 250 260 270 280 290 300 450 460 pF1KE1 ASPLQSLLEVLGLLGGVIMMVLIAHLE .: .:: ..: : .:...:::.. XP_011 EDPWRSLQQLLLLCAGIVVMVLFSLFVD 310 320 330 >>XP_011518771 (OMIM: 608735,612350) PREDICTED: zinc tra (350 aa) initn: 664 init1: 307 opt: 500 Z-score: 496.4 bits: 100.7 E(85289): 6.6e-21 Smith-Waterman score: 558; 35.6% identity (60.2% similar) in 354 aa overlap (119-466:67-346) 90 100 110 120 130 140 pF1KE1 HHGHSHGYSHESLYHRGHGHDHEHSHGGYGESGAPGIKQDLDAVTLWAYALGATVLISAA :: . : . . . : .: ...... . XP_011 LALELLERAGGSQPALRSRGTATACRLDNKESESWGALLSGERLDTWICSLLGSLMVGLS 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE1 PFFVLFLIPVESNSP-RHRS---LLQILLSFASGGLLGDAFLHLIPHALEPHSHHTLEQP : :..::.: .. : .. :. ::::: :::::..::::.:.: .. .: XP_011 GVFPLLVIPLEMGTMLRSEAGAWRLKQLLSFALGGLLGNVFLHLLPEAW---AYTCSASP 100 110 120 130 140 150 210 220 230 240 250 260 pF1KE1 GHGHSHSGQGPILSVGLWVLSGIVAFLVVEKFVRHVKGGHGHSHGHGHAHSHTRGSHGHG : :...: : ..::::..::..::..::. XP_011 G-GEGQSLQQQ-QQLGLWVIAGILTFLALEKMF--------------------------- 160 170 180 270 280 290 300 310 320 pF1KE1 RQERSTKEKQSSEEEEKETRGVQKRRGGSTVPKDGPVRPQNAEEEKRGLDLRVSGYLNLA .:.:: :.. .::::::: XP_011 ---------LDSKEE------------GTS---------------------QVSGYLNLL 190 200 330 340 350 360 370 380 pF1KE1 ADLAHNFTDGLAIGASFRGGRGLGILTTMTVLLHEVPHEVGDFAILVQSGCSKKQAMRLQ :. ::: :::..::: .. .:.::::..::::.::::::::::...: .. .: .:: XP_011 ANTIDNFTHGLAVAASFLVSKKIGLLTTMAILLHEIPHEVGDFAILLRAGFDRWSAAKLQ 210 220 230 240 250 260 390 400 410 420 430 440 pF1KE1 LLTAVGALAGTACALLTEG--GAVGSEIAGGAGPGWVLPFTAGGFIYVATVSVLPELLRE : ::.:.: :.. :. :.. :.:: :. .::::::.:::.:.: :.:::.::.: XP_011 LSTALGGLLGAGFAICTQSPKGVVGCSPAAEETAAWVLPFTSGGFLYIALVNVLPDLLEE 270 280 290 300 310 320 450 460 pF1KE1 ASPLQSLLEVLGLLGGVIMMVLIAHLE .: .:: ..: : .:...:::.. XP_011 EDPWRSLQQLLLLCAGIVVMVLFSLFVD 330 340 350 >>NP_689477 (OMIM: 608735,612350) zinc transporter ZIP13 (364 aa) initn: 646 init1: 312 opt: 487 Z-score: 483.5 bits: 98.4 E(85289): 3.4e-20 Smith-Waterman score: 612; 36.6% identity (62.8% similar) in 355 aa overlap (119-466:52-360) 90 100 110 120 130 140 pF1KE1 HHGHSHGYSHESLYHRGHGHDHEHSHGGYGESGAPGIKQDLDAVTLWAYALGATVLISAA :: . : . . . : .: ...... . NP_689 LALELLGRAGGSQPALRSRGTATACRLDNKESESWGALLSGERLDTWICSLLGSLMVGLS 30 40 50 60 70 80 150 160 170 180 190 200 pF1KE1 PFFVLFLIPVESNSP-RHRS---LLQILLSFASGGLLGDAFLHLIPHALEPHSHHTLEQP : :..::.: .. : .. :. ::::: :::::..::::.:.: .. .: NP_689 GVFPLLVIPLEMGTMLRSEAGAWRLKQLLSFALGGLLGNVFLHLLPEAW---AYTCSASP 90 100 110 120 130 210 220 230 240 250 260 pF1KE1 GHGHSHSGQGPILSVGLWVLSGIVAFLVVEKFVRHVKGGHGHSHGHGHAHSHTRGSHGHG : :...: : ..::::..::..::..::. NP_689 G-GEGQSLQQQ-QQLGLWVIAGILTFLALEKMFL-------------------------- 140 150 160 170 270 280 290 300 310 320 pF1KE1 RQERSTKEKQSSEEEEKETRGVQKRRGGSTVPKDGPVRPQNAEEEKRGL---DLRVSGYL ..::. .:. .:. .. .: : : : : : ...::::: NP_689 ----DSKEEGTSQAPNKDPTAAAAALNG------GHCLAQPAAEPGLGAVVRSIKVSGYL 180 190 200 210 220 330 340 350 360 370 380 pF1KE1 NLAADLAHNFTDGLAIGASFRGGRGLGILTTMTVLLHEVPHEVGDFAILVQSGCSKKQAM :: :. ::: :::..::: .. .:.::::..::::.::::::::::...: .. .: NP_689 NLLANTIDNFTHGLAVAASFLVSKKIGLLTTMAILLHEIPHEVGDFAILLRAGFDRWSAA 230 240 250 260 270 280 390 400 410 420 430 440 pF1KE1 RLQLLTAVGALAGTACALLTEGGAVGSEIAGGAGPGWVLPFTAGGFIYVATVSVLPELLR .::: ::.:.: :.. :. :.. : : .::::::.:::.:.: :.:::.::. NP_689 KLQLSTALGGLLGAGFAICTQSPKGVEETA-----AWVLPFTSGGFLYIALVNVLPDLLE 290 300 310 320 330 450 460 pF1KE1 EASPLQSLLEVLGLLGGVIMMVLIAHLE : .: .:: ..: : .:...:::.. NP_689 EEDPWRSLQQLLLLCAGIVVMVLFSLFVD 340 350 360 469 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 16 15:03:18 2016 done: Wed Nov 16 15:03:20 2016 Total Scan time: 9.950 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]