Result of FASTA (omim) for
pF1KE1328
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1328, 364 aa
1>>>pF1KE1328 364 - 364 aa - 364 aa
Library: /omim/omim.rfq.tfa
64704883 residues in 91410 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.4578+/-0.000309; mu= 15.8064+/- 0.019
mean_var=64.4184+/-12.797, 0's: 0 Z-trim(116.5): 21 B-trim: 417 in 1/49
Lambda= 0.159797
statistics sampled from 28754 (28775) to 28754 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.698), E-opt: 0.2 (0.315), width: 16
Scan time: 3.820
The best scores are: opt bits E(91410)
NP_002525 (OMIM: 164350,222100) 2'-5'-oligoadenyla ( 364) 2507 586.4 3.6e-167
XP_006719497 (OMIM: 164350,222100) 2'-5'-oligoaden ( 384) 2389 559.2 5.8e-159
NP_001027581 (OMIM: 164350,222100) 2'-5'-oligoaden ( 414) 2388 559.0 7.3e-159
NP_001307080 (OMIM: 164350,222100) 2'-5'-oligoaden ( 360) 2386 558.5 8.9e-159
NP_058132 (OMIM: 164350,222100) 2'-5'-oligoadenyla ( 400) 2381 557.4 2.2e-158
XP_011536715 (OMIM: 164350,222100) 2'-5'-oligoaden ( 406) 1932 453.9 3.2e-127
XP_016874850 (OMIM: 164350,222100) 2'-5'-oligoaden ( 392) 1925 452.3 9.4e-127
NP_058197 (OMIM: 603350) 2'-5'-oligoadenylate synt ( 719) 1259 298.8 2.7e-80
NP_002526 (OMIM: 603350) 2'-5'-oligoadenylate synt ( 687) 1258 298.6 3e-80
XP_016874851 (OMIM: 164350,222100) 2'-5'-oligoaden ( 237) 1227 291.2 1.7e-78
XP_016874852 (OMIM: 603351) 2'-5'-oligoadenylate s (1038) 977 233.9 1.4e-60
NP_006178 (OMIM: 603351) 2'-5'-oligoadenylate synt (1087) 977 233.9 1.4e-60
XP_005253946 (OMIM: 603351) 2'-5'-oligoadenylate s (1089) 977 233.9 1.4e-60
XP_016875629 (OMIM: 603281) 2'-5'-oligoadenylate s ( 366) 834 200.7 4.6e-51
NP_003724 (OMIM: 603281) 2'-5'-oligoadenylate synt ( 514) 834 200.8 6.2e-51
NP_937856 (OMIM: 603281) 2'-5'-oligoadenylate synt ( 255) 464 115.4 1.6e-25
XP_016875630 (OMIM: 603281) 2'-5'-oligoadenylate s ( 255) 464 115.4 1.6e-25
NP_001248754 (OMIM: 603281) 2'-5'-oligoadenylate s ( 384) 459 114.3 5.1e-25
NP_001027903 (OMIM: 603350) 2'-5'-oligoadenylate s ( 172) 253 66.6 5e-11
>>NP_002525 (OMIM: 164350,222100) 2'-5'-oligoadenylate s (364 aa)
initn: 2507 init1: 2507 opt: 2507 Z-score: 3122.8 bits: 586.4 E(91410): 3.6e-167
Smith-Waterman score: 2507; 99.7% identity (100.0% similar) in 364 aa overlap (1-364:1-364)
10 20 30 40 50 60
pF1KE1 MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 GGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 VQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGSYKPNPQIYVKLIEECTDL
:::::::::::::::::::::::::::::::::::::::::.::::::::::::::::::
NP_002 VQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEECTDL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 QKEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKLGKLPPQYALELLTVYAW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QKEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKLGKLPPQYALELLTVYAW
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 ERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVILD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVILD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 PADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILLVRPPASSLPFIPAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILLVRPPASSLPFIPAP
310 320 330 340 350 360
pF1KE1 LHEA
::::
NP_002 LHEA
>>XP_006719497 (OMIM: 164350,222100) 2'-5'-oligoadenylat (384 aa)
initn: 2389 init1: 2389 opt: 2389 Z-score: 2975.4 bits: 559.2 E(91410): 5.8e-159
Smith-Waterman score: 2389; 99.4% identity (100.0% similar) in 348 aa overlap (1-348:1-348)
10 20 30 40 50 60
pF1KE1 MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 GGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 VQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGSYKPNPQIYVKLIEECTDL
:::::::::::::::::::::::::::::::::::::::::.::::::::::::::::::
XP_006 VQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEECTDL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 QKEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKLGKLPPQYALELLTVYAW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QKEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKLGKLPPQYALELLTVYAW
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 ERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVILD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVILD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 PADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILLVRPPASSLPFIPAP
::::::::::::::::::::::::::::::::::::::::::::::.:
XP_006 PADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILLMRQRLREVRSLAQG
310 320 330 340 350 360
pF1KE1 LHEA
XP_006 HQLTSGGNGIQAQWTLKPVLMSLC
370 380
>>NP_001027581 (OMIM: 164350,222100) 2'-5'-oligoadenylat (414 aa)
initn: 2385 init1: 2385 opt: 2388 Z-score: 2973.6 bits: 559.0 E(91410): 7.3e-159
Smith-Waterman score: 2388; 97.8% identity (98.9% similar) in 356 aa overlap (1-355:1-356)
10 20 30 40 50 60
pF1KE1 MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 GGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 VQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGSYKPNPQIYVKLIEECTDL
:::::::::::::::::::::::::::::::::::::::::.::::::::::::::::::
NP_001 VQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEECTDL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 QKEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKLGKLPPQYALELLTVYAW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QKEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKLGKLPPQYALELLTVYAW
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 ERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVILD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVILD
250 260 270 280 290 300
310 320 330 340 350
pF1KE1 PADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILLVR-PPASSLPFIPA
::::::::::::::::::::::::::::::::::::::::::::::.. :.: :
NP_001 PADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILLTQHTPGSIHPTGRR
310 320 330 340 350 360
360
pF1KE1 PLHEA
NP_001 GLDLHHPLNASASWGKGLQCYLDQFLHFQVGLLIQRGQSSSVSWCIIQDRTQVS
370 380 390 400 410
>>NP_001307080 (OMIM: 164350,222100) 2'-5'-oligoadenylat (360 aa)
initn: 2386 init1: 2386 opt: 2386 Z-score: 2972.1 bits: 558.5 E(91410): 8.9e-159
Smith-Waterman score: 2386; 99.7% identity (100.0% similar) in 347 aa overlap (1-347:1-347)
10 20 30 40 50 60
pF1KE1 MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 GGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 VQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGSYKPNPQIYVKLIEECTDL
:::::::::::::::::::::::::::::::::::::::::.::::::::::::::::::
NP_001 VQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEECTDL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 QKEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKLGKLPPQYALELLTVYAW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QKEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKLGKLPPQYALELLTVYAW
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 ERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVILD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVILD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 PADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILLVRPPASSLPFIPAP
:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILLVNLTLVGRRNYTNN
310 320 330 340 350 360
pF1KE1 LHEA
>>NP_058132 (OMIM: 164350,222100) 2'-5'-oligoadenylate s (400 aa)
initn: 2381 init1: 2381 opt: 2381 Z-score: 2965.1 bits: 557.4 E(91410): 2.2e-158
Smith-Waterman score: 2381; 99.7% identity (100.0% similar) in 346 aa overlap (1-346:1-346)
10 20 30 40 50 60
pF1KE1 MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_058 MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 GGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_058 GGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 VQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGSYKPNPQIYVKLIEECTDL
:::::::::::::::::::::::::::::::::::::::::.::::::::::::::::::
NP_058 VQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEECTDL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 QKEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKLGKLPPQYALELLTVYAW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_058 QKEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKLGKLPPQYALELLTVYAW
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 ERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVILD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_058 ERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVILD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 PADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILLVRPPASSLPFIPAP
::::::::::::::::::::::::::::::::::::::::::::::
NP_058 PADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILLAESNSADDETDDPR
310 320 330 340 350 360
pF1KE1 LHEA
NP_058 RYQKYGYIGTHEYPHFSHRPSTLQAASTPQAEEDWTCTIL
370 380 390 400
>>XP_011536715 (OMIM: 164350,222100) 2'-5'-oligoadenylat (406 aa)
initn: 1954 init1: 1050 opt: 1932 Z-score: 2405.6 bits: 453.9 E(91410): 3.2e-127
Smith-Waterman score: 1932; 82.4% identity (88.5% similar) in 357 aa overlap (1-355:1-348)
10 20 30 40 50 60
pF1KE1 MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 GGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFE
70 80 90 100 110 120
130 140 150 160 170
pF1KE1 VQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGSYKPNPQIYV-KLIEECTD
::::::::::::::::::::::::::::::::::::.. : ..: . : .:... :.
XP_011 VQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALAH-RGVHRPAERGRVLHLLHRTTE
130 140 150 160 170
180 190 200 210 220 230
pF1KE1 LQKEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKLGKLPPQYALELLTVYA
:. .. . .: . . . . :::::::::::::::::::::
XP_011 RLPEAA--------PHQAQEPHPPSQALVPKCMALPPGLCKKKLGKLPPQYALELLTVYA
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE1 WERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVIL
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE1 DPADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILLVR-PPASSLPFIP
:::::::::::::::::::::::::::::::::::::::::::::::.. :.: :
XP_011 DPADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILLTQHTPGSIHPTGR
300 310 320 330 340 350
360
pF1KE1 APLHEA
XP_011 RGLDLHHPLNASASWGKGLQCYLDQFLHFQVGLLIQRGQSSSVSWCIIQDRTQVS
360 370 380 390 400
>>XP_016874850 (OMIM: 164350,222100) 2'-5'-oligoadenylat (392 aa)
initn: 1950 init1: 1050 opt: 1925 Z-score: 2397.1 bits: 452.3 E(91410): 9.4e-127
Smith-Waterman score: 1925; 83.9% identity (89.3% similar) in 347 aa overlap (1-346:1-338)
10 20 30 40 50 60
pF1KE1 MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 GGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFE
70 80 90 100 110 120
130 140 150 160 170
pF1KE1 VQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGSYKPNPQIYV-KLIEECTD
::::::::::::::::::::::::::::::::::::.. : ..: . : .:... :.
XP_016 VQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALAH-RGVHRPAERGRVLHLLHRTTE
130 140 150 160 170
180 190 200 210 220 230
pF1KE1 LQKEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKLGKLPPQYALELLTVYA
:. .. . .: . . . . :::::::::::::::::::::
XP_016 RLPEAA--------PHQAQEPHPPSQALVPKCMALPPGLCKKKLGKLPPQYALELLTVYA
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE1 WERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVIL
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE1 DPADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILLVRPPASSLPFIPA
:::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILLAESNSADDETDDP
300 310 320 330 340 350
360
pF1KE1 PLHEA
XP_016 RRYQKYGYIGTHEYPHFSHRPSTLQAASTPQAEEDWTCTIL
360 370 380 390
>>NP_058197 (OMIM: 603350) 2'-5'-oligoadenylate synthase (719 aa)
initn: 1308 init1: 525 opt: 1259 Z-score: 1563.2 bits: 298.8 E(91410): 2.7e-80
Smith-Waterman score: 1259; 52.7% identity (77.5% similar) in 355 aa overlap (4-352:340-690)
10 20 30
pF1KE1 MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHA
: .::.. :::::...: :. :: ::. :
NP_058 WLKKEAQTWLTSPNLDNELPAPSWNVLPAPLFTTPGHLLDKFIKEFLQPNKCFLEQIDSA
310 320 330 340 350 360
40 50 60 70 80 90
pF1KE1 IDIICGFLKERCFRGSSYPVCVSKVVKGGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLN
..:: :::: ::: :. . ..:.:::..:::.:. :::::::: . : .. .: :
NP_058 VNIIRTFLKENCFRQSTAKI---QIVRGGSTAKGTALKTGSDADLVVFHNSLKSYTSQKN
370 380 390 400 410 420
100 110 120 130 140 150
pF1KE1 RRGEFIQEIRRQLEACQRERAFSVKFEVQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAF
.: ....::..::.: ::. .. . :.: ::.::: :.: :.:.: :::::::
NP_058 ERHKIVKEIHEQLKAFWREKEEELEVSFEPPKWKAPRVLSFSLKSKVLNESVSFDVLPAF
430 440 450 460 470 480
160 170 180 190 200 210
pF1KE1 DALGQLTGSYKPNPQIYVKLIE--ECTDLQKEGEFSTCFTELQRDFLKQRPTKLKSLIRL
.:::::... :.:..:. ::. . .:: :::::::: :::.:...::::::.::::
NP_058 NALGQLSSGSTPSPEVYAGLIDLYKSSDLPG-GEFSTCFTVLQRNFIRSRPTKLKDLIRL
490 500 510 520 530 540
220 230 240 250 260
pF1KE1 VKHWYQNCKKKL---GKLPPQYALELLTVYAWERGSMKTHFNTAQGFRTVLELVINYQQL
:::::..:..:: :.:::.:::::::.::::.:: :.::.::::::::: .::::
NP_058 VKHWYKECERKLKPKGSLPPKYALELLTIYAWEQGSGVPDFDTAEGFRTVLELVTQYQQL
550 560 570 580 590 600
270 280 290 300 310 320
pF1KE1 CIYWTKYYDFKNPIIEKYLRRQLTKPRPVILDPADPTGNLGGGDPKGWRQLAQEAEAWLN
::.: :.:.. ..:.: :: : ::::::::.:::..:::: :. ::.::. ::.
NP_058 CIFWKVNYNFEDETVRKFLLSQLQKTRPVILDPAEPTGDVGGGDRWCWHLLAKEAKEWLS
610 620 630 640 650 660
330 340 350 360
pF1KE1 YPCFKNWDGSPVSSW-ILLVRPPASSLPFIPAPLHEA
::::. :.:. : . .. :.:
NP_058 SPCFKDGTGNPIPPWKVPTMQTPGSCGARIHPIVNEMFSSRSHRILNNNSKRNF
670 680 690 700 710
>--
initn: 828 init1: 312 opt: 818 Z-score: 1013.8 bits: 197.2 E(91410): 1.1e-49
Smith-Waterman score: 818; 40.7% identity (66.2% similar) in 349 aa overlap (4-349:8-339)
10 20 30 40 50
pF1KE1 MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVS
: ..::..: ::..:: : . :.. .. :: :.: ..:. :.
NP_058 MGNGESQLSSVPAQKLGWFIQEYLKPYEECQTLIDEMVNTICDVLQE----PEQFPL-VQ
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 KVVKGGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFS
:. ::: :. :.::: ::. ::.:.: : :::: . ..... .:. : . ..
NP_058 GVAIGGSYGRKTVLRGNSDGTLVLFFSDLKQFQDQKRSQRDILDKTGDKLKFCLFTKWLK
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 VKFEVQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGSYKPNPQIYVKLIEE
.::.: : :... . .. . :.:: ::.:: . . .:.: :: .: .
NP_058 NNFEIQKSLDG------FTIQVFTKNQRISFEVLAAFNAL---SLNDNPSPWIYRELKRS
120 130 140 150 160
180 190 200 210 220 230
pF1KE1 CTDLQ-KEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKLGKLPP--QYALE
. . :::..::::::. :. .:: :::.:: :.:::.:.:.::. :: ::::
NP_058 LDKTNASPGEFAVCFTELQQKFFDNRPGKLKDLILLIKHWHQQCQKKIKDLPSLSPYALE
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE1 LLTVYAWERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTK
::::::::.: : .:. :.: ::::::. ..::::: :.:.. :.. : .:: .
NP_058 LLTVYAWEQGCRKDNFDIAEGVRTVLELIKCQEKLCIYWMVNYNFEDETIRNILLHQLQS
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE1 PRPVILDPADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILLVRPPASS
:::::::.:::.:..: : :. : .::..::. : . : :. :: .: :
NP_058 ARPVILDPVDPTNNVSG-DKICWQWLKKEAQTWLTSPNLDNE--LPAPSWNVLPAPLFTT
290 300 310 320 330 340
360
pF1KE1 LPFIPAPLHEA
NP_058 PGHLLDKFIKEFLQPNKCFLEQIDSAVNIIRTFLKENCFRQSTAKIQIVRGGSTAKGTAL
350 360 370 380 390 400
>>NP_002526 (OMIM: 603350) 2'-5'-oligoadenylate synthase (687 aa)
initn: 1308 init1: 525 opt: 1258 Z-score: 1562.3 bits: 298.6 E(91410): 3e-80
Smith-Waterman score: 1258; 53.1% identity (77.7% similar) in 350 aa overlap (4-348:340-685)
10 20 30
pF1KE1 MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHA
: .::.. :::::...: :. :: ::. :
NP_002 WLKKEAQTWLTSPNLDNELPAPSWNVLPAPLFTTPGHLLDKFIKEFLQPNKCFLEQIDSA
310 320 330 340 350 360
40 50 60 70 80 90
pF1KE1 IDIICGFLKERCFRGSSYPVCVSKVVKGGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLN
..:: :::: ::: :. . ..:.:::..:::.:. :::::::: . : .. .: :
NP_002 VNIIRTFLKENCFRQSTAKI---QIVRGGSTAKGTALKTGSDADLVVFHNSLKSYTSQKN
370 380 390 400 410 420
100 110 120 130 140 150
pF1KE1 RRGEFIQEIRRQLEACQRERAFSVKFEVQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAF
.: ....::..::.: ::. .. . :.: ::.::: :.: :.:.: :::::::
NP_002 ERHKIVKEIHEQLKAFWREKEEELEVSFEPPKWKAPRVLSFSLKSKVLNESVSFDVLPAF
430 440 450 460 470 480
160 170 180 190 200 210
pF1KE1 DALGQLTGSYKPNPQIYVKLIE--ECTDLQKEGEFSTCFTELQRDFLKQRPTKLKSLIRL
.:::::... :.:..:. ::. . .:: :::::::: :::.:...::::::.::::
NP_002 NALGQLSSGSTPSPEVYAGLIDLYKSSDLPG-GEFSTCFTVLQRNFIRSRPTKLKDLIRL
490 500 510 520 530 540
220 230 240 250 260
pF1KE1 VKHWYQNCKKKL---GKLPPQYALELLTVYAWERGSMKTHFNTAQGFRTVLELVINYQQL
:::::..:..:: :.:::.:::::::.::::.:: :.::.::::::::: .::::
NP_002 VKHWYKECERKLKPKGSLPPKYALELLTIYAWEQGSGVPDFDTAEGFRTVLELVTQYQQL
550 560 570 580 590 600
270 280 290 300 310 320
pF1KE1 CIYWTKYYDFKNPIIEKYLRRQLTKPRPVILDPADPTGNLGGGDPKGWRQLAQEAEAWLN
::.: :.:.. ..:.: :: : ::::::::.:::..:::: :. ::.::. ::.
NP_002 CIFWKVNYNFEDETVRKFLLSQLQKTRPVILDPAEPTGDVGGGDRWCWHLLAKEAKEWLS
610 620 630 640 650 660
330 340 350 360
pF1KE1 YPCFKNWDGSPVSSWILLVRPPASSLPFIPAPLHEA
::::. :.:. : . :.
NP_002 SPCFKDGTGNPIPPWKVPVKVI
670 680
>--
initn: 828 init1: 312 opt: 818 Z-score: 1014.1 bits: 197.1 E(91410): 1e-49
Smith-Waterman score: 818; 40.7% identity (66.2% similar) in 349 aa overlap (4-349:8-339)
10 20 30 40 50
pF1KE1 MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVS
: ..::..: ::..:: : . :.. .. :: :.: ..:. :.
NP_002 MGNGESQLSSVPAQKLGWFIQEYLKPYEECQTLIDEMVNTICDVLQE----PEQFPL-VQ
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 KVVKGGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFS
:. ::: :. :.::: ::. ::.:.: : :::: . ..... .:. : . ..
NP_002 GVAIGGSYGRKTVLRGNSDGTLVLFFSDLKQFQDQKRSQRDILDKTGDKLKFCLFTKWLK
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 VKFEVQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGSYKPNPQIYVKLIEE
.::.: : :... . .. . :.:: ::.:: . . .:.: :: .: .
NP_002 NNFEIQKSLDG------FTIQVFTKNQRISFEVLAAFNAL---SLNDNPSPWIYRELKRS
120 130 140 150 160
180 190 200 210 220 230
pF1KE1 CTDLQ-KEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKLGKLPP--QYALE
. . :::..::::::. :. .:: :::.:: :.:::.:.:.::. :: ::::
NP_002 LDKTNASPGEFAVCFTELQQKFFDNRPGKLKDLILLIKHWHQQCQKKIKDLPSLSPYALE
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE1 LLTVYAWERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTK
::::::::.: : .:. :.: ::::::. ..::::: :.:.. :.. : .:: .
NP_002 LLTVYAWEQGCRKDNFDIAEGVRTVLELIKCQEKLCIYWMVNYNFEDETIRNILLHQLQS
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE1 PRPVILDPADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILLVRPPASS
:::::::.:::.:..: : :. : .::..::. : . : :. :: .: :
NP_002 ARPVILDPVDPTNNVSG-DKICWQWLKKEAQTWLTSPNLDNE--LPAPSWNVLPAPLFTT
290 300 310 320 330 340
360
pF1KE1 LPFIPAPLHEA
NP_002 PGHLLDKFIKEFLQPNKCFLEQIDSAVNIIRTFLKENCFRQSTAKIQIVRGGSTAKGTAL
350 360 370 380 390 400
>>XP_016874851 (OMIM: 164350,222100) 2'-5'-oligoadenylat (237 aa)
initn: 1227 init1: 1227 opt: 1227 Z-score: 1530.9 bits: 291.2 E(91410): 1.7e-78
Smith-Waterman score: 1227; 100.0% identity (100.0% similar) in 174 aa overlap (173-346:10-183)
150 160 170 180 190 200
pF1KE1 EGVEFDVLPAFDALGQLTGSYKPNPQIYVKLIEECTDLQKEGEFSTCFTELQRDFLKQRP
::::::::::::::::::::::::::::::
XP_016 MCCLPLMPWLIEECTDLQKEGEFSTCFTELQRDFLKQRP
10 20 30
210 220 230 240 250 260
pF1KE1 TKLKSLIRLVKHWYQNCKKKLGKLPPQYALELLTVYAWERGSMKTHFNTAQGFRTVLELV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TKLKSLIRLVKHWYQNCKKKLGKLPPQYALELLTVYAWERGSMKTHFNTAQGFRTVLELV
40 50 60 70 80 90
270 280 290 300 310 320
pF1KE1 INYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVILDPADPTGNLGGGDPKGWRQLAQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 INYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVILDPADPTGNLGGGDPKGWRQLAQE
100 110 120 130 140 150
330 340 350 360
pF1KE1 AEAWLNYPCFKNWDGSPVSSWILLVRPPASSLPFIPAPLHEA
::::::::::::::::::::::::
XP_016 AEAWLNYPCFKNWDGSPVSSWILLAESNSADDETDDPRRYQKYGYIGTHEYPHFSHRPST
160 170 180 190 200 210
364 residues in 1 query sequences
64704883 residues in 91410 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Jul 14 21:18:43 2018 done: Sat Jul 14 21:18:43 2018
Total Scan time: 3.820 Total Display time: 0.100
Function used was FASTA [36.3.4 Apr, 2011]