Result of FASTA (omim) for
pF1KE1345
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1345, 264 aa
1>>>pF1KE1345 264 - 264 aa - 264 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1324+/-0.000323; mu= 16.4024+/- 0.020
mean_var=76.9875+/-15.059, 0's: 0 Z-trim(116.8): 8 B-trim: 0 in 0/55
Lambda= 0.146172
statistics sampled from 28171 (28179) to 28171 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.728), E-opt: 0.2 (0.33), width: 16
Scan time: 7.560
The best scores are: opt bits E(85289)
NP_006160 (OMIM: 600008) nicotinamide N-methyltran ( 264) 1759 380.0 2.5e-105
NP_006765 (OMIM: 604854) indolethylamine N-methylt ( 263) 894 197.6 2e-50
NP_001186148 (OMIM: 604854) indolethylamine N-meth ( 262) 886 195.9 6.5e-50
NP_002677 (OMIM: 171190) phenylethanolamine N-meth ( 282) 592 133.9 3.1e-31
XP_011523211 (OMIM: 171190) PREDICTED: phenylethan ( 184) 439 101.5 1.2e-21
>>NP_006160 (OMIM: 600008) nicotinamide N-methyltransfer (264 aa)
initn: 1759 init1: 1759 opt: 1759 Z-score: 2012.1 bits: 380.0 E(85289): 2.5e-105
Smith-Waterman score: 1759; 100.0% identity (100.0% similar) in 264 aa overlap (1-264:1-264)
10 20 30 40 50 60
pF1KE1 MESGFTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILKHLLKNLFKIFCLDGVKGDLLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MESGFTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILKHLLKNLFKIFCLDGVKGDLLI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 DIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKKEPEAFDWSPVVTYVCDLEGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 DIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKKEPEAFDWSPVVTYVCDLEGN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 RVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 RVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRAL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 RNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 RNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQ
190 200 210 220 230 240
250 260
pF1KE1 SYSSTMANNEGLFSLVARKLSRPL
::::::::::::::::::::::::
NP_006 SYSSTMANNEGLFSLVARKLSRPL
250 260
>>NP_006765 (OMIM: 604854) indolethylamine N-methyltrans (263 aa)
initn: 891 init1: 891 opt: 894 Z-score: 1026.2 bits: 197.6 E(85289): 2e-50
Smith-Waterman score: 894; 53.2% identity (74.5% similar) in 263 aa overlap (1-263:1-263)
10 20 30 40 50 60
pF1KE1 MESGFTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILKHLLKNLFKIFCLDGVKGDLLI
:..:::. : : .:: ::::: ::.: . : :...:: :. : : : :..:: ::
NP_006 MKGGFTGGDEYQKHFLPRDYLATYYSFDGSPSPEAEMLKFNLECLHKTFGPGGLQGDTLI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 DIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKKEPEAFDWSPVVTYVCDLEGN
::::::::::.:.::.::..:...:..:.: .:::::::::: :.::.:.: ..:.::::
NP_006 DIGSGPTIYQVLAACDSFQDITLSDFTDRNREELEKWLKKEPGAYDWTPAVKFACELEGN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 RVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRAL
. ::::::: :::.:::::: ..::. . :: :::::. : .. :: .: .: ::
NP_006 SGRWEEKEEKLRAAVKRVLKCDVHLGNPLAPAVLPLADCVLTLLAMECACCSLDAYRAAL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 RNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQ
::.::::::: :: .:. ::.:...:: . : .: :: :: .::. :: . :
NP_006 CNLASLLKPGGHLVTTVTLRLPSYMVGKREFSCVALEKEEVEQAVLDAGFDIEQLLHSPQ
190 200 210 220 230 240
250 260
pF1KE1 SYSSTMANNEGLFSLVARKLSRPL
::: : : :.:. .:::: :
NP_006 SYSVTNAANNGVCFIVARKKPGP
250 260
>>NP_001186148 (OMIM: 604854) indolethylamine N-methyltr (262 aa)
initn: 885 init1: 747 opt: 886 Z-score: 1017.1 bits: 195.9 E(85289): 6.5e-50
Smith-Waterman score: 886; 53.2% identity (74.5% similar) in 263 aa overlap (1-263:1-262)
10 20 30 40 50 60
pF1KE1 MESGFTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILKHLLKNLFKIFCLDGVKGDLLI
:..:::. : : .:: ::::: ::.: . : :...:: :. : : : :..:: ::
NP_001 MKGGFTGGDEYQKHFLPRDYLATYYSFDGSPSPEAEMLKFNLECLHKTFG-PGLQGDTLI
10 20 30 40 50
70 80 90 100 110 120
pF1KE1 DIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKKEPEAFDWSPVVTYVCDLEGN
::::::::::.:.::.::..:...:..:.: .:::::::::: :.::.:.: ..:.::::
NP_001 DIGSGPTIYQVLAACDSFQDITLSDFTDRNREELEKWLKKEPGAYDWTPAVKFACELEGN
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE1 RVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRAL
. ::::::: :::.:::::: ..::. . :: :::::. : .. :: .: .: ::
NP_001 SGRWEEKEEKLRAAVKRVLKCDVHLGNPLAPAVLPLADCVLTLLAMECACCSLDAYRAAL
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE1 RNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQ
::.::::::: :: .:. ::.:...:: . : .: :: :: .::. :: . :
NP_001 CNLASLLKPGGHLVTTVTLRLPSYMVGKREFSCVALEKEEVEQAVLDAGFDIEQLLHSPQ
180 190 200 210 220 230
250 260
pF1KE1 SYSSTMANNEGLFSLVARKLSRPL
::: : : :.:. .:::: :
NP_001 SYSVTNAANNGVCFIVARKKPGP
240 250 260
>>NP_002677 (OMIM: 171190) phenylethanolamine N-methyltr (282 aa)
initn: 583 init1: 345 opt: 592 Z-score: 681.6 bits: 133.9 E(85289): 3.1e-31
Smith-Waterman score: 592; 39.7% identity (67.9% similar) in 252 aa overlap (15-260:30-280)
10 20 30 40
pF1KE1 MESGFTSKDTYLSHFNPRDYLEKYYKFGSRHS--AESQILKHLLK
:.:: ::.. : : . . . :.
NP_002 MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYA-PPRGDLCNPNGVGPWKLR
10 20 30 40 50
50 60 70 80 90 100
pF1KE1 NLFKIFCLDGVKGDLLIDIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKKEPE
: . : :.: :::::::::.::::::: :..:..::. . : ::: .::..::
NP_002 CLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPG
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE1 AFDWSPVVTYVCDLEGNRVKGPEKEEKLRQAVKQVLKCDVTQSQPLGA-VPLP-PADCVL
::.:: ..: .::. .::..:: ::.:: :: : ::::: : : ::: ..
NP_002 AFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALV
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE1 STLCLDAACPDLPTYCRALRNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAV
:..::.:. ::: .. ::: .. .::.::: :... ::. :.:. :: ... .:...: :
NP_002 SAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEV
180 190 200 210 220 230
230 240 250 260
pF1KE1 EAAVKEAGYTIEWFE--VISQSYSSTMANNEGLFSLVARKLSRPL
. :. ..:: .. .. .. .. . . .:.: :.:.
NP_002 REALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
240 250 260 270 280
>>XP_011523211 (OMIM: 171190) PREDICTED: phenylethanolam (184 aa)
initn: 428 init1: 232 opt: 439 Z-score: 509.8 bits: 101.5 E(85289): 1.2e-21
Smith-Waterman score: 439; 38.5% identity (70.3% similar) in 182 aa overlap (83-260:1-182)
60 70 80 90 100 110
pF1KE1 GVKGDLLIDIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKKEPEAFDWSPVVT
.::. . : ::: .::..:: ::.::
XP_011 MTDFLEVNRQELGRWLQEEPGAFNWSMYSQ
10 20 30
120 130 140 150 160 170
pF1KE1 YVCDLEGNRVKGPEKEEKLRQAVKQVLKCDVTQSQPLGA-VPLP-PADCVLSTLCLDAAC
..: .::. .::..:: ::.:: :: : ::::: : : ::: ..:..::.:.
XP_011 HACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVSAFCLEAVS
40 50 60 70 80 90
180 190 200 210 220 230
pF1KE1 PDLPTYCRALRNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGY
::: .. ::: .. .::.::: :... ::. :.:. :: ... .:...: :. :. ..::
XP_011 PDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSGY
100 110 120 130 140 150
240 250 260
pF1KE1 TIEWFE--VISQSYSSTMANNEGLFSLVARKLSRPL
.. .. .. .. . . .:.: :.:.
XP_011 KVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
160 170 180
264 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 23:37:46 2016 done: Sun Nov 6 23:37:47 2016
Total Scan time: 7.560 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]